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https://www.readbyqxmd.com/read/28351128/nanoparticles-of-titanium-and-zinc-oxides-as-novel-agents-in-tumor-treatment-a-review
#1
Janusz Bogdan, Joanna Pławińska-Czarnak, Joanna Zarzyńska
Cancer has become a global problem. On all continents, a great number of people are diagnosed with this disease. In spite of the progress in medical care, cancer still ends fatal for a great number of the ill, either as a result of a late diagnosis or due to inefficiency of therapies. The majority of the tumors are resistant to drugs. Thus, the search for new, more effective therapy methods continues. Recently, nanotechnology has been attributed with big expectations in respect of the cancer fight. That interdisciplinary field of science creates nanomaterials (NMs) and nanoparticles (NPs) that can be applied, e...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28351079/editorial-to-methamphetamine-crystal-meth-and-new-psychoactive-substances
#2
Ulrich S Zimmermann
No abstract text is available yet for this article.
March 28, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28351071/neurologic-deficits-have-a-negative-impact-on-patient-related-outcomes-in-primary-presentation-adult-symptomatic-lumbar-scoliosis-surgical-treatment-at-one-year-follow-up
#3
Daniel G Kang, Christine Baldus, Steven D Glassman, Christopher I Shaffrey, Jon D Lurie, Keith H Bridwell
STUDY DESIGN: A retrospective analysis of prospective, multicenter National Institute of Health clinical trial. OBJECTIVE: The aim of this study was to assess the rate of neurologic complications and impact of new neurologic deficits on 1-year postoperative patient-reported outcomes (PROs). SUMMARY OF BACKGROUND DATA: There are limited studies evaluating the impact of new neurologic deficits on PROs following surgery for primary presentation adult lumbar scoliosis...
April 1, 2017: Spine
https://www.readbyqxmd.com/read/28351061/hittability-the-leader-s-edge
#4
Wiley Souba
Mastery of any discipline entails both the requisite skills and the ability to see things as "hittable." However, the concept of "hittability," which, in the context of leadership, refers to whether or not a specific leadership challenge shows up as hittable (or solvable) for those who are responsible for taking it on, is consistently overlooked. Nevertheless, it is a critical determinant of leadership effectiveness. Hittability is a function of the framing lenses-a person's beliefs, values, and worldviews-which frame the way a person "sees" a leadership challenge...
April 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28351056/comparison-of-umbilical-serum-copeptin-relative-to-erythropoietin-and-s100b-as-asphyxia-biomarkers-at-birth
#5
Milla Summanen, Laura Seikku, Petri Rahkonen, Vedran Stefanovic, Kari Teramo, Sture Andersson, Kai Kaila, Leena Rahkonen
BACKGROUND: Birth asphyxia, estimated to account for a million neonatal deaths annually, can cause a wide variety of neurodevelopmental impairments. There is a need to develop new, swift methods to identify those neonates who would benefit from neuroprotective treatments such as hypothermia. OBJECTIVES: To examine the utility of cord serum copeptin, a stable byproduct of arginine vasopressin release, as a biomarker of birth asphyxia based on a comparison with 2 biomarkers of hypoxia and brain trauma: erythropoietin and S100B...
March 29, 2017: Neonatology
https://www.readbyqxmd.com/read/28351051/insights-into-the-physiopathology-of-inflammatory-macular-edema
#6
Marc D de Smet
Macular edema is one of the most common causes of permanent vision loss in patients with uveitis. The current understanding of water balance and metabolism within the retina has given us better insight into the mechanisms underlying macular edema arising from both acute and chronic inflammation. Uveitic macular edema (UME) occurs when the equilibrium between water influx and efflux is lost, and more importantly when compensatory mechanisms are overwhelmed. While in the acute setting, control of inflammation can reestablish homeostasis, chronic inflammation can lead to alternate pathways to establish a water balance...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351049/macular-edema-of-choroidal-origin
#7
Gisèle Soubrane
Macular edema is most often clinically defined as an accumulation of serous fluid within the neurosensory retina with increased thickness of the central retina. In exudative age-related macular degeneration the leakage of fluid from the choroidal new vessels may be the origin of macular edema. Their abnormal permeability and the inflammatory reaction are mechanisms involved in this accumulation of fluid, which occurs in all layers. Cystoid macular edema is more often associated with subepithelial occult choroidal neovascularization (CNV) than it is with pre-epithelial classic CNV...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351045/optical-coherence-tomography-angiography-in-macular-edema
#8
Marco Lupidi, Florence Coscas, Carlo Cagini, Gabriel Coscas
OCT angiography is a promising new method to visualize the retinal vasculature and choroidal vascular layers in the macular area and provides depth resolved functional information of the blood flow in the vessels. Given that the main moving elements in the eye fundus are contained in vessels, determining a vascular decorrelation signal enables visualization of 3-dimensional retinal and choroidal vascular network without the administration of intravenous dye and thus reducing the risk of potential adverse events...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351042/intracellular-edema
#9
Raja Narayanan, Baruch D Kuppermann
The macula is predisposed to edema in various retinal conditions, even when the insult is remote from the macula. The various factors that may predispose the macula to edema include high metabolic activity, radial arrangement of the Henle's layer, lack of inner layers at the fovea, and lack of blood supply at the fovea. The edema is most pronounced in the outer plexiform layer (Henle's layer). Alteration in the blood-retinal barrier and ischemia cause disturbances in vascular permeability as well as with the function of Müller cells...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351028/influence-of-feeding-types-during-the-first-months-of-life-on-calciuria-levels-in-healthy-infants-a-secondary-analysis-from-a-randomized-clinical-trial
#10
Natalia Ferré, Carmen Rubio-Torrents, Veronica Luque, Ricardo Closa-Monasterolo, Veit Grote, Berthold Koletzko, Piotr Socha, Dariusz Gruszfeld, Jean Paul Langhendries, Anne Sengier, Elvira Verduci, Joaquin Escribano
BACKGROUND/AIMS: Dietary factors can modify calciuria. We aim to investigate urinary calcium excretion in healthy infants according to their protein. METHODS: Secondary data analysis from a randomized clinical trial where healthy term infants were randomized after birth to a higher (HP) or lower (LP) protein content formula that was consumed until age 1 year. A non-randomized group of breastfed (BF) infants was used for reference. Anthropometry, dietary intakes and calciuria (calcium/creatinine ratios) from spot urine samples were assessed at ages 3 and 6 months...
March 29, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28351020/optimization-of-a-new-methodology-for-trace-determination-of-elements-in-biological-fluids-application-for-speciation-of-inorganic-selenium-in-children-s-blood
#11
Reza Akramipour, Mitra Hemati, Nazir Fattahi, Meghdad Pirsaheb, Toraj Ahmadi-Jouibari
The continuous sample drop flow microextraction (CSDFME) joined with the iridium-modified tube graphite furnace atomic absorption spectrometry (GFAAS) has been developed as a highly sensitive technique for the speciation of selenium in blood samples. In this method 32.0μl carbon tetrachloride is transferred to the bottom of a conical sample cup. Then the 5.0ml of aqueous solution transforms to fine droplets while passing through the organic solvent. At this stage, Se(IV)-APDC hydrophobic complex is extracted into the organic solvent...
March 22, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28351011/fine-cutting-edge-shaped-bi2o3rods-reduced-graphene-oxide-rgo-composite-for-supercapacitor-and-visible-light-photocatalytic-applications
#12
D Maruthamani, S Vadivel, M Kumaravel, B Saravanakumar, Bappi Paul, Siddhartha Sankar Dhar, Aziz Habibi-Yangjeh, A Manikandan, Govindarajan Ramadoss
Bi2O3 rods/RGO composite has been synthesized by a simple precipitation and calcination method. The crystallnity, structural, and morphological features were studied by X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM), and high resolution transmission electron microscopy (HR-TEM) techniques. The supercapacitor behavior was studied using cyclic voltammetry, galvanostatic charge discharge and impedance analysis, respectively. The Bi2O3 rods/RGO nanocomposite exhibits a maximum specific capacitance of 1041Fg(-1) at a current density of 2Ag(-1)...
March 22, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28351010/vanadium-sulfide-sub-microspheres-a-new-near-infrared-driven-photocatalyst
#13
Yanli Zhou, Pengfei Liu, Fuyi Jiang, Jian Tian, Hongzhi Cui, Jian Yang
Recently, finding a novel near-infrared (NIR) photocatalyst has been the focus in photocatalysis. Here, VS4 sub-microspheres with a chain-like structure were prepared via a facile solvothermal method. As a new photocatalyst, it presents excellent NIR photocatalytic and photoelectrochemical (PEC) activity. Theoretical calculations and experimental results demonstrate that the improved NIR photocatalytic property originated from the narrow band gap of VS4, which significantly improves the NIR light absorption...
March 21, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28351005/nrf-2-driven-long-noncoding-rna-odrul-contributes-to-modulating-silver-nanoparticle-induced-effects-on-erythroid-cells
#14
Ming Gao, Beibei Zhao, Minjun Chen, Yun Liu, Ming Xu, Zhe Wang, Sijin Liu, Chengdong Zhang
The biosafety and biological effects of silver nanoparticles (AgNPs) on human health attract increasing concern. Although considerable studies have been performed to reveal the molecular mechanisms responsible for AgNP-induced effects, the current understanding mainly focuses on oxidative stress-associated signaling pathways activated by Ag particles and/or Ag ions. However, the molecular bases underlying the activation of these stress signaling pathways have not been thoroughly elucidated yet. In the current study, we aimed to shed light on the molecular bases of AgNP-induced effects on erythroid cells from the perspective of long noncoding RNAs...
March 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/28351000/targeted-superparamagnetic-nanoparticles-coated-with-2-deoxy-d-gloucose-and-doxorubicin-more-sensitize-breast-cancer-cells-to-ionizing-radiation
#15
Jalil Pirayesh Islamian, Milad Hatamian, Negar Abbasi Aval, Mohammad Reza Rashidi, Asghar Mesbahi, Mohammad Mohammadzadeh, Mohammad Asghari Jafarabadi
INTRODUCTION: Nanoparticles are promising as a new approach to enhance chemo- radiotherapy efficiency in breast cancer mainly via targeted therapy. MATERIALS & METHODS: SKBR3 and T47D breast cancer cells were treated with superparamagnetic mesoporous hydroxyapatite nanocomposites (SPmHANs)conjugated with 1 μM doxorubicin and 0.5 mM 2-Deoxy-d-Glucose and irradiated with 1 and 2 Gy gamma rays in vitro. The treatment toxicity and also the apoptosis/necrosis ratio were measured by MTT assay and also ELISA cell death detection PLUS, respectively...
March 25, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28350998/anticancer-copper-ii-phosphorus-dendrimers-are-potent-proapoptotic-bax-activators
#16
Serge Mignani, Nabil El Brahmi, Laure Eloy, Joel Poupon, Valérie Nicolas, Anke Steinmetz, Said El Kazzouli, Mosto M Bousmina, Mireille Blanchard-Desce, Anne-Marie Caminade, Jean-Pierre Majoral, Thierry Cresteil
A multivalent phosphorus dendrimer 1G3 and its corresponding Cu-complex, 1G3-Cu have been recently identified as agents retaining high antiproliferative potency. This antiproliferative capacity was preserved in cell lines overexpressing the efflux pump ABC B1, whereas cross-resistance was observed in ovarian cancer cell lines resistant to cisplatin. Theoretical 3D models were constructed: the dendrimers appear as irregularly shaped disk-like nano-objects of about 22 Å thickness and 49 Å diameter, which accumulated in cells after penetration by endocytosis...
March 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28350997/synthesis-and-biological-evaluation-of-hypoxia-activated-prodrugs-of-sn-38
#17
Chen Jin, Qiumeng Zhang, Wei Lu
We designed new hypoxia-activated prodrugs by conjugating (1-methyl-2-nitro-1H-imidazol-5-yl)methanol with 7-ethyl-10-hydroxy camptothecin (SN-38). Initially, we improved the method of multi-gram scale synthesis of (1-methyl-2-nitro-1H-imidazol-5-yl)methanol, which increased the yield to 42% compared to 8% by the original synthesis method. The improved method was used to synthesize evofosfamide (TH-302) and hypoxia-activated prodrugs of SN-38. Two different linkages between (1-methyl-2-nitro-1H-imidazol-5-yl)methanol and SN-38 were evaluated that afforded different hypoxia-selectivity and toxicity...
March 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28350984/autophagy-it-s-in-your-blood
#18
Sergei Doulatov, George Q Daley
Autophagy, a central pathway for cellular homeostasis, plays diverse roles in development, cancer, aging, and neurodegeneration. In a new report in Nature, Ho et al. (2017) show that autophagy is essential for maintaining the replicative quiescence of hematopoietic stem cells throughout life by limiting the number of active mitochondria.
March 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28350971/early-discharge-after-total-thyroidectomy-a-retrospective-feasibility-study
#19
F Tartaglia, A Giuliani, S Sorrenti, L Tromba, S Carbotta, A Maturo, G Carbotta, L De Anna, R Merola, G Livadoti, F Pelle, S Ulisse
AIM: The continued hospitalization after total thyroidectomy is often due to the onset of hypocalcemic complications more than 24 hours after surgery. So it would be important to predict which patients will not develop the hypocalcemic complication to discharge them early. This was the aim of our study. PATIENTS AND METHODS: Our retrospective study was conducted on 327 consecutive thyroidectomized patients, operated on for benign and malignant diseases. We evaluated the values of preoperative serum calcium levels (Cal0) and of the first postoperative day (Cal1) and two new variables were calculated (dCal and dCaln)...
November 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28350968/induced-pluripotent-stem-cell-derived-cardiomyocytes-cardiac-applications-opportunities-and-challenges
#20
Adrien Moreau, Mohamed Boutjdir, Mohamed Chahine
Chronic diseases are the primary cause of mortality worldwide, accounting for 67% of deaths. One of the major challenges in developing new treatments is the lack of understanding of the exact underlying biological and molecular mechanisms. Chronic cardiovascular diseases are the single most common cause of death worldwide, and sudden deaths due to cardiac arrhythmias account for approximately 50% of all such cases. Traditional genetic screening for genes involved in cardiac disorders is laborious and frequently fails to detect the mutation that explains or causes the disorder...
March 28, 2017: Canadian Journal of Physiology and Pharmacology
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