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https://www.readbyqxmd.com/read/28748194/recurrent-metatarsal-fractures-in-postmenopausal-woman-with-low-serum-alkaline-phosphatase-a-rare-diagnosis-not-to-miss
#1
Umair Iqbal, Hafsa Anwar, Ahmad Chaudhary, Madiha Alvi, Amy Freeth
Hypophosphatasia (HPP) is a rare inborn error of metabolism due to a loss-of-function mutation in the gene for tissue nonspecific isoenzyme of alkaline phosphatase (ALP) that results in low levels of ALP. The clinical presentation of HPP is variable and in adults can easily be misdiagnosed as other forms of osteomalacia. We present a case of a 53-year-old Caucasian female who was evaluated for recurrent metatarsal fractures. She reported her first metatarsal fracture at age 21, and since then had at least 8 more metatarsal fractures over her lifetime, most without injury other than weight bearing...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28747338/copy-number-loss-in-the-region-of-the-aspn-gene-in-patients-with-acetabular-dysplasia-aspn-cnv-in-acetabular-dysplasia
#2
T Sekimoto, M Ishii, M Emi, S Kurogi, T Funamoto, Y Yonezawa, T Tajima, T Sakamoto, H Hamada, E Chosa
OBJECTIVES: We have previously investigated an association between the genome copy number variation (CNV) and acetabular dysplasia (AD). Hip osteoarthritis is associated with a genetic polymorphism in the aspartic acid repeat in the N-terminal region of the asporin (ASPN) gene; therefore, the present study aimed to investigate whether the CNV of ASPN is involved in the pathogenesis of AD. METHODS: Acetabular coverage of all subjects was evaluated using radiological findings (Sharp angle, centre-edge (CE) angle, acetabular roof obliquity (ARO) angle, and minimum joint space width)...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28746489/three-dimensional-evaluation-of-mandibular-anterior-dental-crowding-in-digital-dental-casts
#3
Luciana Quintanilha Pires Fernandes, Livia Kelly Ferraz Nunes, Luana Santos Alves, Felipe de Assis Carvalho Ribeiro, Jonas Capelli
Introduction: Digital dental models provide a more accurate and comprehensive assessment of orthodontic cases. Although this technique is quite promising, there are few three-dimensional measurements methods described in the literature. Objective: The aim of this study was to propose a method for assessing the degree of mandibular anterior dental crowding in the three planes of space, using digital dental models. Methods: Thirty dental casts were selected and scanned by Maestro 3D Dental Scanner and imported by Geomagic Qualify 2013 software...
May 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28746381/hedgehogs-on-the-move-testing-the-effects-of-land-use-change-on-home-range-size-and-movement-patterns-of-free-ranging-ethiopian-hedgehogs
#4
Mohammad A Abu Baker, Nigel Reeve, April A T Conkey, David W Macdonald, Nobuyuki Yamaguchi
Degradation and alteration of natural environments because of agriculture and other land uses have major consequences on vertebrate populations, particularly on spatial organization and movement patterns. We used GPS tracking to study the effect of land use and sex on the home range size and movement of a typical model species, the Ethiopian hedgehogs. We used free-ranging hedgehogs from two areas with different land use practices: 24 from an area dominated by irrigated farms (12 ♂♂, 12 ♀♀) and 22 from a natural desert environment within a biosphere reserve (12 ♂♂, 10 ♀♀)...
2017: PloS One
https://www.readbyqxmd.com/read/28746338/detecting-epistasis-with-the-marginal-epistasis-test-in-genetic-mapping-studies-of-quantitative-traits
#5
Lorin Crawford, Ping Zeng, Sayan Mukherjee, Xiang Zhou
Epistasis, commonly defined as the interaction between multiple genes, is an important genetic component underlying phenotypic variation. Many statistical methods have been developed to model and identify epistatic interactions between genetic variants. However, because of the large combinatorial search space of interactions, most epistasis mapping methods face enormous computational challenges and often suffer from low statistical power due to multiple test correction. Here, we present a novel, alternative strategy for mapping epistasis: instead of directly identifying individual pairwise or higher-order interactions, we focus on mapping variants that have non-zero marginal epistatic effects-the combined pairwise interaction effects between a given variant and all other variants...
July 26, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28744744/the-effect-of-neoadjuvant-chemoradiation-on-anastomotic-leak-and-additional-30-day-morbidity-and-mortality-in-patients-undergoing-total-gastrectomy-for-gastric-cancer
#6
Ivy N Haskins, Matthew D Kroh, Richard L Amdur, Jeffrey L Ponksy, John H Rodriguez, Khashayar Vaziri
INTRODUCTION: In addition to increased perioperative morbidity, anastomotic leak following gastric resection for gastric cancer can have detrimental effects on overall and disease-free survival. The risk of anastomotic leak following neoadjuvant therapy remains unknown. The purpose of this study is to investigate the association of preoperative chemotherapy and radiation therapy with postoperative anastomotic leak and additional 30-day morbidity and mortality outcomes following total gastrectomy with reconstruction for gastric cancer using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP)...
July 25, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28743605/three-dimensional-analysis-of-the-pharyngeal-airway-space-and-hyoid-bone-position-after-orthognathic-surgery
#7
Amanda Lury Yamashita, Liogi Iwaki Filho, Pablo Cornélius Comelli Leite, Ricardo de Lima Navarro, Adilson Luiz Ramos, Isolde Terezinha Santos Previdelli, Matheus Henrique Dal Molin Ribeiro, Lilian Cristina Vessoni Iwaki
PURPOSE: The aim of this study was to evaluate changes in the pharyngeal airway space (PAS) and hyoid bone position after orthognathic surgery with cone-beam computed tomography (CBCT). MATERIAL AND METHODS: This study was conducted with the tomographic records of 30 patients with skeletal class II or III deformities submitted to two different types of orthognathic surgery: Group 1 (n = 15), maxillary advancement, and mandibular setback; and Group 2 (n = 15), maxillomandibular advancement...
July 4, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28742992/utilizing-secondary-agricultural-education-programs-to-deliver-evidence-based-grain-safety-training-for-young-and-beginning-workers
#8
Yuan-Hsin Cheng, William E Field, Roger L Tormoehlen, Brian F French
Purdue University's Agricultural Safety and Health Program (PUASHP) has collaborated with secondary agricultural education programs, including FFA Chapters, for over 70 years to deliver and promote agricultural safety and health programming. With support from a U.S. Department of Labor Susan Harwood Program grant, PUASHP utilized a Developing a Curriculum (DACUM) process to develop, implement, and evaluate an evidence-based curriculum for use with young and beginning workers, ages 16-20, exposed to hazards associated with grain storage and handling...
July 25, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28742059/spanning-the-scales-of-mechanical-metamaterials-using-time-domain-simulations-in-transformed-crystals-graphene-flakes-and-structured-soils
#9
Ronald Aznavourian, Tania Michelle Guenneau-Puvirajesinghe, Stephane Brule, Stefan Enoch, Sebastien Roger Guenneau
We begin with a brief historical survey of discoveries of quasi-crystals and graphene, and then introduce the concept of transformation crystallography, which consists of the application of geometric transforms to periodic structures. We consider motifs with three-fold, four-fold and six-fold symmetries according to the crystallographic restriction theorem. Furthermore, we define motifs with five-fold symmetry such as quasi-crystals generated by a cut-and-projection method from periodic structures in higher-dimensional space...
July 25, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28741142/proteomic-expression-changes-in-large-cerebral-arteries-after-experimental-subarachnoid-hemorrhage-in-rat-are-regulated-by-the-mek-erk1-2-pathway
#10
Anne H Müller, Alistair V G Edwards, Martin R Larsen, Janne Nielsen, Karin Warfvinge, Gro K Povlsen, Lars Edvinsson
Subarachnoid hemorrhage (SAH) is a serious clinical condition where leakage of blood into the subarachnoid space causes an acute rise in intracranial pressure and reduces cerebral blood flow, which may lead to delayed cerebral ischemia and poor outcome. In experimental SAH, we have previously shown that the outcome can be significantly improved by early inhibition of the MAPK/ERK kinase/extracellular signal-regulated kinase (MEK/ERK1/2) pathway. The aim of this study was to apply mass spectrometry to investigate the overall late effects of experimental SAH on cerebrovascular protein expression...
July 24, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28740862/giant-convecting-mud-balls-of-the-early-solar-system
#11
Philip A Bland, Bryan J Travis
Carbonaceous asteroids may have been the precursors to the terrestrial planets, yet despite their importance, numerous attempts to model their early solar system geological history have not converged on a solution. The assumption has been that hydrothermal alteration was occurring in rocky asteroids with material properties similar to meteorites. However, these bodies would have accreted as a high-porosity aggregate of igneous clasts (chondrules) and fine-grained primordial dust, with ice filling much of the pore space...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28739018/prediction-effects-of-personal-psychosocial-and-occupational-risk-factors-on-low-back-pain-severity-using-artificial-neural-networks-approach-in-industrial-workers
#12
Ebrahim Darvishi, Hassan Khotanlou, Jamshid Khoubi, Omid Giahi, Neda Mahdavi
OBJECTIVES: This study aimed to provide an empirical model of predicting low back pain (LBP) by considering the occupational, personal, and psychological risk factor interactions in workers population employed in industrial units using an artificial neural networks approach. METHODS: A total of 92 workers with LBP as the case group and 68 healthy workers as a control group were selected in various industrial units with similar occupational conditions. The demographic information and personal, occupational, and psychosocial factors of the participants were collected via interview, related questionnaires, consultation with occupational medicine, and also the Rapid Entire Body Assessment worksheet and National Aeronautics and Space Administration Task Load Index software...
July 21, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28738587/a-novel-calibration-strategy-based-on-background-correction-for-quantitative-circular-dichroism-spectroscopy
#13
Qi Zuo, Shun Xiong, Zeng-Ping Chen, Yao Chen, Ru-Qin Yu
When using circular dichroism (CD) spectroscopy for quantitative analysis, the samples to be analyzed must be free of light-absorbing interferences. However, in real-world samples, the presence of background absorbers is practically unavoidable. The difference in the matrices between the real-world samples to be analyzed and the standard samples (on which either univariate or multivariate calibration model was built) would result in systematic errors in the quantification results of CD spectroscopy. In this contribution, a novel calibration strategy for quantitative CD spectroscopic analysis was proposed...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738153/electronic-coupling-for-donor-bridge-acceptor-systems-with-a-bridge-overlap-approach
#14
Alessandro Biancardi, Seth C Martin, Cameron Liss, Marco Caricato
Understanding the modulation of the electronic coupling in donor-acceptor systems connected through an aliphatic bridge is crucial from a fundamental point of view as well as for the development of organic electronics. In this work, we present a first-principles approach for the calculation of the electronic coupling (or transfer integrals) in such systems via a block-diagonalization of the Fock/Kohn-Sham matrix of the supersystem, followed by a projection on the basis of the fragment orbitals of the donor and acceptor groups...
July 24, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28738113/estrogen-status-gates-effects-of-kappa-opioid-receptor-on-temporomandibular-joint-responsive-neurons-at-the-spinomedullary-junction-in-female-rats
#15
Akimasa Tashiro, David A Bereiter, Yasuhiro Nishida
AIMS: To determine whether estrogen status alters κ-opioid inhibition of nociceptive processing by affecting temporomandibular joint (TMJ) input to neurons in the trigeminal subnucleus caudalis [Vc]/C1-2 region at the spinomedullary junction in female rats. METHODS: TMJ-responsive neurons were recorded in laminae I-II of the Vc/C1-2 region at the spinomedullary junction of ovariectomized female rats treated for 2 days with low-dose estradiol (LE group; 2 mg/day) or high-dose estradiol (HE group; 20 mg/day)...
July 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28737675/3d-reconstruction-of-space-objects-from-multi-views-by-a-visible-sensor
#16
Haopeng Zhang, Quanmao Wei, Zhiguo Jiang
In this paper, a novel 3D reconstruction framework is proposed to recover the 3D structural model of a space object from its multi-view images captured by a visible sensor. Given an image sequence, this framework first estimates the relative camera poses and recovers the depths of the surface points by the structure from motion (SFM) method, then the patch-based multi-view stereo (PMVS) algorithm is utilized to generate a dense 3D point cloud. To resolve the wrong matches arising from the symmetric structure and repeated textures of space objects, a new strategy is introduced, in which images are added to SFM in imaging order...
July 22, 2017: Sensors
https://www.readbyqxmd.com/read/28736750/a-novel-defibrillation-tool-percutaneously-delivered-partially-insulated-epicardial-defibrillation
#17
Ammar M Killu, Niyada Naksuk, Zdeněk Stárek, Christopher V DeSimone, Faisal F Syed, Prakriti Gaba, Jiří Wolf, Frantisek Lehar, Martin Pesl, Pavel Leinveber, Michal Crha, Dorothy Ladewig, Joanne Powers, Scott Suddendorf, David O Hodge, Gaurav Satam, Miroslav Novák, Tomas Kara, Charles J Bruce, Paul A Friedman, Samuel J Asirvatham
INTRODUCTION: Epicardial defibrillation systems currently require surgical access. We aimed to develop a percutaneous defibrillation system with partially-insulated epicardial coils to focus electrical energy on the myocardium and prevent or minimize extra-cardiac stimulation. METHODS: We tested 2 prototypes created for percutaneous introduction into the pericardial space via a steerable sheath. This included a partially-insulated defibrillation coil and a defibrillation mesh with a urethane balloon acting as an insulator to the face of the mesh not in contact with the epicardium...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28736736/feedback-driven-sensory-mapping-adaptation-for-robust-speech-activity-detection
#18
Ashwin Bellur, Mounya Elhilali
Parsing natural acoustic scenes using computational methodologies poses many challenges. Given the rich and complex nature of the acoustic environment, data mismatch between train and test conditions is a major hurdle in data-driven audio processing systems. In contrast, the brain exhibits a remarkable ability at segmenting acoustic scenes with relative ease. When tackling challenging listening conditions that are often faced in everyday life, the biological system relies on a number of principles that allow it to effortlessly parse its rich soundscape...
March 2017: IEEE/ACM Transactions on Audio, Speech, and Language Processing
https://www.readbyqxmd.com/read/28736181/succinate-accumulation-impairs-cardiac-pyruvate-dehydrogenase-activity-through-grp91-dependent-and-independent-signaling-pathways-therapeutic-effects-of-ginsenoside-rb1
#19
Jia Li, Yi-Lin Yang, Lan-Zhu Li, Lei Zhang, Qun Liu, Kang Liu, Ping Li, Baolin Liu, Lian-Wen Qi
Altered mitochondrial oxidation increases vulnerability to cardiac ischemia/reperfusion (I/R) injury in metabolic disorders. However, the metabolic signaling responsible for the dysfunction remains partly unknown. We sought to test whether or not hypoxic succinate accumulation could inhibit pyruvate dehydrogenase (PDH) activity and subsequently aggravate I/R injury. Results showed that saturated fatty acid palmitate stimulation increased fatty acid oxidation and induced hypoxia in cardiomyocytes, leading to succinate accumulation...
July 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28736148/risk-and-protective-factors-in-the-lives-of-transgender-gender-nonconforming-adolescents
#20
Marla E Eisenberg, Amy L Gower, Barbara J McMorris, G Nicole Rider, Glynis Shea, Eli Coleman
PURPOSE: Research suggests that transgender and gender nonconforming (TGNC) youth may be at greatly increased risk of high-risk health behaviors compared with cisgender youth, but existing studies are limited by convenience samples and small numbers. This study uses a large school-based sample of adolescents to describe the prevalence of TGNC identity, associations with health risk behaviors and protective factors, and differences across birth-assigned sex. METHODS: This study analyzes existing surveillance data provided by 9th and 11th grade students in Minnesota in 2016 (N = 81,885)...
July 20, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
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