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https://www.readbyqxmd.com/read/28239609/application-of-taxonomic-modeling-to-microbiota-data-mining-for-detection-of-helminth-infection-in-global-populations
#1
Mahbaneh Eshaghzadeh Torbati, Makedonka Mitreva, Vanathi Gopalakrishnan
Human microbiome data from genomic sequencing technologies is fast accumulating, giving us insights into bacterial taxa that contribute to health and disease. The predictive modeling of such microbiota count data for the classification of human infection from parasitic worms, such as helminths, can help in the detection and management across global populations. Real-world datasets of microbiome experiments are typically sparse, containing hundreds of measurements for bacterial species, of which only a few are detected in the bio-specimens that are analyzed...
December 2016: Data (Basel)
https://www.readbyqxmd.com/read/28239236/assessing-composition-and-structure-of-soft-biphasic-media-from-kelvin-voigt-fractional-derivative-model-parameters
#2
Hong Mei Zhang, Yue Wang, Mostafa Fatemi, Michael F Insana
Kelvin-Voigt fractional derivative (KVFD) model parameters have been used to describe viscoelastic properties of soft tissues. However, translating model parameters into a concise set of intrinsic mechanical properties related to tissue composition and structure remains challenging. This paper begins by exploring these relationships using a biphasic emulsion materials with known composition. Mechanical properties are measured by analyzing data from two indentation techniques - ramp-stress relaxation and load-unload hysteresis tests...
March 2017: Measurement Science & Technology
https://www.readbyqxmd.com/read/28238814/neural-basis-of-cognitive-assessment-in-alzheimer-disease-amnestic-mild-cognitive-impairment-and-subjective-memory-complaints
#3
Jordi A Matías-Guiu, María Nieves Cabrera-Martín, María Valles-Salgado, Alicia Pérez-Pérez, Teresa Rognoni, Teresa Moreno-Ramos, José Luis Carreras, Jorge Matías-Guiu
INTRODUCTION: Interpreting cognitive tests is often challenging. The same test frequently examines multiple cognitive functions, and the functional and anatomical basis underlying test performance is unknown in many cases. This study analyses the correlation of different neuropsychological test results with brain metabolism in a series of patients evaluated for suspected Alzheimer disease. METHODS: 20 healthy controls and 80 patients consulting for memory loss were included, in which cognitive study and (18)F-fluorodeoxyglucose PET were performed...
February 3, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28238777/up-regulation-of-igf-1-in-the-frontal-cortex-of-piglets-exposed-to-an-environmentally-enriched-arena
#4
Sarah M Brown, Rebecca Peters, Alistair B Lawrence
Environmental enrichment (EE) is widely used in the life sciences to study effects of environment on the brain. In pigs, despite lack of EE being a key welfare issue there is little understanding of brain effects of EE in pigs. This project aimed to study the effects of exposure to an EE arena on piglet behaviours and on brain gene expression levels with a focus on IGF-1 and related genes. Eight litters of large white×landrace×Hampshire piglets were farrowed and raised in a free farrowing system (PigSAFE)...
February 23, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28238034/35-years-of-marine-natural-product-research-in-sweden-cool-molecules-and-models-from-cold-waters
#5
Lars Bohlin, Paco Cárdenas, Anders Backlund, Ulf Göransson
Currents efforts in marine biodiscovery have essentially focused on temperate to tropical shallow water organisms. With more than 6000 species of marine plants and animals, the Kosterfjord area has the richest marine biodiversity in Swedish waters, but it remains understudied. The overall objective of our marine pharmacognosy research is to explore and reveal the pharmacological potential of organisms from this poorly explored region. More generally, we wish to understand aspects of structure-activity relationships of chemical interactions in cold-water marine environment (shallow and deep)...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28237521/recoupling-dipolar-interactions-with-multiple-i-1-quadrupolar-nuclei-a-11-b-6-li-and-31-p-6-li-rotational-echo-double-resonance-study-of-lithium-borophosphate-glasses
#6
Lena Marie Funke, Henrik Bradtmüller, Hellmut Eckert
The case of rotational echo double resonance (REDOR) experiments on the observe nuclei (11)B and (31)P interacting with multiple I=1 quadrupolar nuclei is analyzed in detail by SIMPSON simulations and experimental studies. The simulations define the region within the parameter space spanned by nutation frequency, quadrupolar coupling constant and spinning frequency where the parabolic analysis of the initial REDOR curve in terms of dipolar second moments has validity. The predictions are tested by experimental studies on the crystalline model compounds lithium diborate and lithium pyrophosphate, which are subsequently extended to measure dipolar second moments M2((11)B{(6)Li}) and M2((31)P{(6)Li}) in three borophosphate glasses...
February 20, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28236124/prevalence-and-clinical-significance-of-lumbosacral-transitional-vertebra-lstv-in-a-young-back-pain-population-with-suspected-axial-spondyloarthritis-results-of-the-spondyloarthritis-caught-early-space-cohort
#7
F de Bruin, S Ter Horst, J L Bloem, R van den Berg, M de Hooge, F van Gaalen, H Dagfinrud, M van Oosterhout, R Landewé, D van der Heijde, M Reijnierse
OBJECTIVE: To determine in a cohort of young patients with suspected axial spondyloarthritis (axSpA), the prevalence of lumbosacral transitional vertebra (LSTV), its association with local bone marrow edema (BME) and lumbar spine degeneration, and the potential relationship with MRI findings and clinical signs of axSpA. MATERIALS AND METHODS: Baseline imaging studies and clinical information of patients from the SPondyloArthritis Caught Early-cohort (back pain ≥3 months, ≤2 years, onset <45 years) were used...
February 24, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28235559/task-inhibition-conflict-and-the-n-2-repetition-cost-a-combined-computational-and-empirical-approach
#8
Nicholas J Sexton, Richard P Cooper
Task inhibition (also known as backward inhibition) is an hypothesised form of cognitive inhibition evident in multi-task situations, with the role of facilitating switching between multiple, competing tasks. This article presents a novel cognitive computational model of a backward inhibition mechanism. By combining aspects of previous cognitive models in task switching and conflict monitoring, the model instantiates the theoretical proposal that backward inhibition is the direct result of conflict between multiple task representations...
February 21, 2017: Cognitive Psychology
https://www.readbyqxmd.com/read/28235517/partial-displacement-of-epidural-catheter-after-patient-position-change-a-case-report
#9
Yoon-Jung Shon, Seung-Kil Bae, Jae-Woo Park, In-Nam Kim, Jin Huh
Epidural catheter migration is a well-known cause of failed anesthesia and complications. One of the factors that affect catheter movement is when patients change their position after skin fixation. We report a case of an epidural catheter placed without evidence of intravascular or subdural insertion that produced an insufficient block. A 36-year-old woman presented for ankle surgery under epidural anesthesia. Epidural block was conducted at the L3-4 intervertebral space with a catheter threaded 3 cm into the epidural space with the patient in a back flexion and lateral position...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28235422/crying-spells-triggered-by-thumb-index-rubbing-after-thalamic-stroke-a-case-report
#10
R Bassani, C Rosazza, L Ghirardin, V Caldiera, E Banco, C Casati, L Tesio
BACKGROUND: Pathologic crying, devoid of any emotional counterpart, is known to occur as a consequence of various brain stem, cortical hemispheric and cerebellar lesions or, quite exceptionally, of "dacrystic" epilepsy. The case reported here suggests that thalamic lesions may also cause crying spells, under the special circumstances described below. CASE PRESENTATION: After a mild left thalamic stroke a caucasian 77 years old man presented with crying spells with no emotional counterpart, triggered by thumb-index rubbing of his right hand...
February 24, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28231638/comparison-of-the-shock-absorption-capacities-of-different-mouthguards
#11
Melina Simonetta Bochnig, Min-Jung Oh, Theresa Nagel, Fred Ziegler, Paul-Georg Jost-Brinkmann
BACKGROUND/AIMS: In this in vitro study the protective qualities of different mouthguard types were examined during small hard object collisions. The aim was to investigate inconclusive aspects of hard inserts, nylon nets and air spaces as reinforcements in the anterior region and the protection qualities of ethylene vinyl acetate (EVA). MATERIALS AND METHODS: Five different mouthguards with a labial thickness between 2 mm and 11 mm made of materials of varying stiffness were investigated...
February 23, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28229984/anatomical-knee-variants-in-discoid-lateral-meniscal-tears
#12
Xu-Xu Chen, Jian Li, Tao Wang, Yang Zhao, Hui Kang
BACKGROUND: Discoid lateral meniscus was a common meniscal dysplasia and was predisposed to tear. There were some anatomical knee variants in patients with discoid lateral meniscus. The aim of this study was to analyze the relationship between anatomical knee variants and discoid lateral meniscal tears. METHODS: There were totally 125 cases of discoid lateral meniscus enrolled in this study from February 2008 to December 2013. Eighty-seven patients who underwent arthroscopic surgery for right torn discoid lateral meniscus were enrolled in the torn group...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28228821/security-of-patient-data-when-decommissioning-ultrasound-systems
#13
James Moggridge
BACKGROUND: Although ultrasound systems generally archive to Picture Archiving and Communication Systems (PACS), their archiving workflow typically involves storage to an internal hard disk before data are transferred onwards. Deleting records from the local system will delete entries in the database and from the file allocation table or equivalent but, as with a PC, files can be recovered. Great care is taken with disposal of media from a healthcare organisation to prevent data breaches, but ultrasound systems are routinely returned to lease companies, sold on or donated to third parties without such controls...
February 2017: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/28228568/mri-visible-perivascular-spaces-in-cerebral-amyloid-angiopathy-and-hypertensive-arteriopathy
#14
Andreas Charidimou, Gregoire Boulouis, Marco Pasi, Eitan Auriel, Ellis S van Etten, Kellen Haley, Alison Ayres, Kristin M Schwab, Sergi Martinez-Ramirez, Joshua N Goldstein, Jonathan Rosand, Anand Viswanathan, Steven M Greenberg, M Edip Gurol
OBJECTIVE: To assess MRI-visible enlarged perivascular spaces (EPVS) burden and different topographical patterns (in the centrum semiovale [CSO] and basal ganglia [BG]) in 2 common microangiopathies: cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). METHODS: Consecutive patients with spontaneous intracerebral hemorrhage (ICH) from a prospective MRI cohort were included. Small vessel disease MRI markers, including cerebral microbleeds (CMBs), cortical superficial siderosis (cSS), and white matter hyperintensities (WMH), were rated...
February 22, 2017: Neurology
https://www.readbyqxmd.com/read/28227999/polysilicon-based-flexible-temperature-sensor-for-high-spatial-resolution-brain-temperature-monitoring
#15
Zhizhen Wu, Chunyan Li, Jed Hartings, Raj K Narayan, Chong Ahn, Zhizhen Wu, Chunyan Li, Jed Hartings, Raj K Narayan, Chong Ahn, Zhizhen Wu, Chunyan Li, Chong Ahn, Jed Hartings, Raj K Narayan
In this paper, we present a flexible temperature sensor with ultra-small polysilicon thermistors for brain temperature monitoring. In vitro sensitivity, resolution, thermal hysteresis and long term stability tests were performed. Temperature coefficient of resistance (TCR) of -0.0031/ °C and resolution of 0.1 °C were obtained for the sensor. Thermal hysteresis for temperature range of 30~45 °C was less than 0.1 °C. With silicon nitride as the passivation layer, the temperature sensor showed a drift within 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227866/modelling-nutrient-transfer-based-on-3d-imaging-of-the-human-placental-microstructure
#16
S Perazzolo, R M Lewis, B G Sengers, S Perazzolo, R M Lewis, B G Sengers, B G Sengers, R M Lewis, S Perazzolo
Impaired transfer of nutrients from mother to fetus can affect pregnancy outcomes. The placenta has a complex microstructure, including the maternal intervillous space and fetal capillaries. Previous computational models of placental transfer either assumed a simplified idealized local geometry or were based on 2D imaging. In this study, we present a novel 3D computational model to assess the placental transfer of nutrients at the microscale in interaction with the maternal flow environment. A stack of confocal microscopy images of the placental terminal villi was collected and reconstructed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227744/classification-of-non-weight-bearing-lower-limb-movements-towards-a-potential-treatment-for-phantom-limb-pain-based-on-myoelectric-pattern-recognition
#17
Eva Lendaro, Max Ortiz-Catalan, Eva Lendaro, Max Ortiz-Catalan, Max Ortiz-Catalan, Eva Lendaro
Research in myoelectric pattern recognition (MPR) for the prediction of motor volition has primarily focused on the upper limbs. Recent studies in the lower limbs have mainly concentrated on prosthetic control, while MPR for lower limb rehabilitation purposes has received little attention. In this work we investigated the viability of a MPR system for the prediction of four degrees of freedom controlled in a near natural or physiologically appropriate fashion. We explored three different electrode configurations for acquiring electromyographic (EMG) signals: two targeted (bipolar and monopolar) and one untargeted (electrodes equally spaced axially)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227715/bivariate-autoregressive-state-space-modeling-of-psychophysiological-time-series-data
#18
Daniel M Smith, Mohammadreza Abtahi, Amir Mohammad Amiri, Kunal Mankodiya, Daniel M Smith, Mohammadreza Abtahi, Amir Mohammad Amiri, Kunal Mankodiya, Kunal Mankodiya, Daniel M Smith, Mohammadreza Abtahi, Amir Mohammad Amiri
Heart rate (HR) and electrodermal activity (EDA) are often used as physiological measures of psychological arousal in various neuropsychology experiments. In this exploratory study, we analyze HR and EDA data collected from four participants, each with a history of suicidal tendencies, during a cognitive task known as the Paced Auditory Serial Addition Test (PASAT). A central aim of this investigation is to guide future research by assessing heterogeneity in the population of individuals with suicidal tendencies...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227506/a-pdms-based-optical-waveguide-for-transcutaneous-powering-of-microelectrode-arrays
#19
Ali Ersen, Mesut Sahin, Ali Ersen, Mesut Sahin, Ali Ersen, Mesut Sahin
Implantable microelectrode arrays (MEAs) usually have on-site electronics that need to be powered, both in neural recording and stimulation applications. Interconnecting wires between implanted electrodes and the outside world constitute a major source of complications. Our solution to this tethering problem is to design a light waveguide that can collect the optical power transcutaneously and transmit it to the microelectrode array where it is to be converted to an electric current. A polydimethylsiloxane (PDMS)-based waveguide was fabricated and its attenuation was measured in vitro and found to be 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227405/template-based-rodent-brain-extraction-and-atlas-mapping
#20
Weimin Huang, Jiaqi Zhang, Zhiping Lin, Su Huang, Yuping Duan, Zhongkang Lu, Weimin Huang, Jiaqi Zhang, Zhiping Lin, Su Huang, Yuping Duan, Zhongkang Lu, Jiaqi Zhang, Weimin Huang, Yuping Duan, Zhongkang Lu, Zhiping Lin, Su Huang
Accurate rodent brain extraction is the basic step for many translational studies using MR imaging. This paper presents a template based approach with multi-expert refinement to automatic rodent brain extraction. We first build the brain appearance model based on the learning exemplars. Together with the template matching, we encode the rodent brain position into the search space to reliably locate the rodent brain and estimate the rough segmentation. With the initial mask, a level-set segmentation and a mask-based template learning are implemented further to the brain region...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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