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https://www.readbyqxmd.com/read/29019276/benzo-a-pyrene-induces-lung-toxicity-and-inflammation-in-mice-prevention-by-carvacrol
#1
P Barnwal, A Vafa, S M Afzal, A Shahid, S K Hasan, Alpashree, S Sultana
Benzo(a)pyrene (B(a)P) is an environmental pollutant which causes various lung toxicities. The present study was designed to evaluate the protective effects of carvacrol, a monoterpenic phenol against B(a)P-induced lung toxicity. In this study, Swiss albino mice were pretreated with carvacrol (25 mg/kg and 50 mg/kg) orally for 7 consecutive days before administering oral B(a)P (125 mg/kg). Preventive efficacy of carvacrol was assessed in terms of membrane oxidation, antioxidant enzyme activities, histopathological changes, and inflammatory (iNOS, NF-κB, and COX-2) markers...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28872728/changes-to-glazed-dental-ceramic-shade-roughness-and-microhardness-after-bleaching-and-simulated-brushing
#2
Carlos Roberto Teixeira Rodrigues, Cecilia Pedroso Turssi, Flávia Lucisano Botelho Amaral, Roberta Tarkany Basting, Fabiana Mantovani Gomes França
PURPOSE: To evaluate shade stability, surface roughness, microhardness, and compressive strength of a glazed feldspathic ceramic subjected to bleaching and simulated brushing. MATERIALS AND METHODS: Eighty-eight glazed feldspathic ceramic specimens were made from microparticulate leucite and divided into eight groups (n = 10). The whitening products used were: Opalescence Trèswhite Supreme (Ultradent), Opalescence®\ PF 15% (Ultradent), and Oral-B 3D White Whitestrips...
September 5, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28852631/comparison-of-efficacy-of-manual-and-powered-toothbrushes-in-plaque-control-and-gingival-inflammation-a-clinical-study-among-the-population-of-east-indian-region
#3
Prasad Kulkarni, Dhirendra Kumar Singh, Mohamed Jalaluddin
AIM AND OBJECTIVE: To figure out, analyze and assess the effectiveness of powered toothbrush (Braun/Oral-B two-dimensional) and manual toothbrush (Oral-B40 Regular Advantage Plus) on supragingival plaque and gingival health. MATERIALS AND METHODS: The efficacy of powered toothbrush to that of manual one was compared by using a randomized clinical trial over a 4 weeks period in controlling plaque and gingivitis using gingival index, plaque index (PI), and oral hygiene index...
July 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28669220/effects-of-octenidine-mouth-rinse-on-apoptosis-and-necrosis-of-human-fibroblasts-and-epithelial-cells-an-in-vitro-study
#4
J Schmidt, V Zyba, K Jung, S Rinke, R Haak, R F Mausberg, D Ziebolz
This study aimed at comparing the cytotoxicity of a new octenidine mouth rinse (MR) on gingival fibroblasts and epithelial cells using different established MRs. Octenidol (OCT), Chlorhexidine 0.2% (CHX), Meridol (MER), Oral B (OB), and control (PBS only) were used. Human primary gingival fibroblasts (HGFIBs) and human primary nasal epithelial cells (HNEPCs) were cultivated in cell-specific media (2 × 10(5) cells/well) and treated with a MR or PBS for 1, 5, and 15 min. All tests were performed in duplicate and repeated 12 times...
July 3, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28609608/voriconazole-concentrations-in-plasma-and-epithelial-lining-fluid-after-inhalation-and-oral-treatment
#5
Charlotte U Andersen, Lene Dahl Sønderskov, Elisabeth Bendstrup, Nina Voldby, Lindsey Cass, John Ayrton, Ole Hilberg
Adverse effects can compromise oral voriconazole treatment of pulmonary aspergillosis. Inhaled low-dose voriconazole may be an alternative treatment. In this study, six patients inhaled 40 mg voriconazole b.i.d. for 2 days, and six patients ingested 400 and 200 mg orally b.i.d. on day one and two, respectively. Blood samples were collected after the first inhalation, and bronchial alveolar lavage fluids and blood samples were collected for measurements of voriconazole 12 hr after the last administration. The concentration of voriconazole in epithelial lining fluid (ELF) was calculated by the urea dilution method...
November 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28422462/a-comparison-of-the-effect-of-two-power-toothbrushes-on-the-gingival-health-and-plaque-status-of-subjects-with-moderate-gingivitis
#6
Michelle Starke, Marcia Delaurenti, Marilyn Ward, Sonia Souza, Kimberly R Milleman, Jeffery L Milleman
OBJECTIVES: To compare the effect of the Philips Sonicare DiamondClean plus Premium plaque control brush head with the Oral-B 7000 plus CrossAction brush head on gingivitis and supragingival plaque reduction following a 42-day period of home use. METHODS: This was a randomized, parallel, examiner-blind, prospective clinical trial conducted on generally healthy subjects. Eligible subjects met the following eligibility criteria: age 18-65, non-smoker, routine manual toothbrush user, ≥ 50 sites of gingival bleeding per the Gingival Bleeding Index (GBI), and ≥ 1...
March 2017: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/28355362/controlled-clinical-trial-addressing-teeth-whitening-with-hydrogen-peroxide-in-adolescents-a-12-month-follow-up
#7
RANDOMIZED CONTROLLED TRIAL
Marcelo Mendes Pinto, Marcela Leticia Leal Gonçalves, Ana Carolina Costa da Mota, Alessandro Melo Deana, Silvia Regina Olivan, Carolina Bortoletto, Camila Haddad Leal de Godoy, Katia Lumi Tanikawa Vergilio, Olga Maria Altavista, Lara J Motta, Sandra Kalil Bussadori
OBJECTIVES: To evaluate the colorimetric change in incisors and canines of adolescents aged 12 to 20 years submitted to at-home whitening and to evaluate satisfaction, sensitivity and discomfort during the procedures through a questionnaire. METHOD: Thirty adolescents were randomly assigned to the following groups: 1) 6.0% hydrogen peroxide (White Class with calcium - FGM); 2) 7.5% hydrogen peroxide (White Class with calcium - FGM); 3) 10% hydrogen peroxide (Oral B 3D White - Oral-B); 4) Control group - placebo...
March 2017: Clinics
https://www.readbyqxmd.com/read/28299466/development-of-oral-cancer-vaccine-using-recombinant-bifidobacterium-displaying-wilms-tumor-1-protein
#8
Koichi Kitagawa, Tsugumi Oda, Hiroki Saito, Ayame Araki, Reina Gonoi, Katsumi Shigemura, Yoshiko Hashii, Takane Katayama, Masato Fujisawa, Toshiro Shirakawa
Several types of vaccine-delivering tumor-associated antigens (TAAs) have been developed in basic and clinical research. Wilms' tumor 1 (WT1), identified as a gene responsible for pediatric renal neoplasm, is one of the most promising TAA for cancer immunotherapy. Peptide and dendritic cell-based WT1 cancer vaccines showed some therapeutic efficacy in clinical and pre-clinical studies but as yet no oral WT1 vaccine can be administrated in a simple and easy way. In the present study, we constructed a novel oral cancer vaccine using a recombinant Bifidobacterium longum displaying WT1 protein...
June 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28222156/toothbrush-abrasivity-in-a-long-term-simulation-on-human-dentin-depends-on-brushing-mode-and-bristle-arrangement
#9
Mozhgan Bizhang, Ilka Schmidt, Yong-Hee Patricia Chun, Wolfgang H Arnold, Stefan Zimmer
OBJECTIVE: The aim of this study was to evaluate the susceptibility of dentin to brushing abrasion using four different toothbrushes (rotating-oscillating, sonic and two types of manual toothbrushes) with the same brushing forces. METHODS: Dentin samples (n = 72) were selected from 72 impacted third molars. Half of the surface of dentin samples was covered with an adhesive tape, creating a protected and a freely exposed area in the same specimen. Brushing was performed with either a: sonic (Sonicare PowerUp, Philips GmbH, Hamburg, Germany), b: oscillating-rotating (Oral B Vitality Precisions Clean, Procter & Gamble, Schwalbach am Taunus, Germany) or two different manual toothbrushes c: flat trim brush head toothbrush (Dr...
2017: PloS One
https://www.readbyqxmd.com/read/28178640/a-phase-i-ii-study-of-the-investigational-drug-alisertib-in-combination-with-abiraterone-and-prednisone-for-patients-with-metastatic-castration-resistant-prostate-cancer-progressing-on-abiraterone
#10
Jianqing Lin, Sheel A Patel, Ashwin R Sama, Jean H Hoffman-Censits, Brooke Kennedy, Deborah Kilpatrick, Zhong Ye, Hushan Yang, Zhaomei Mu, Benjamin Leiby, Nancy Lewis, Massimo Cristofanilli, William Kevin Kelly
LESSONS LEARNED: Patients with metastatic castration-resistant prostate cancer did not tolerate the combination of alisertib with abiraterone and prednisone.There was no clear signal indicating that adding alisertib might be beneficial for those patients progressing on abiraterone. BACKGROUND: We hypothesized that Aurora A kinase (AK) contributes to castrate resistance in prostate cancer (PCa) and that inhibiting AK with alisertib can resensitize PCa cells to androgen receptor (AR) inhibitor abiraterone...
November 2016: Oncologist
https://www.readbyqxmd.com/read/28105737/the-effects-of-power-toothbrushing-on-periodontal-inflammation-in-a-canadian-nursing-home-population-a-randomized-controlled-trial
#11
S E Lavigne, M B Doupe, A M Iacopino, S Mahmud, L Elliott
OBJECTIVES: The aim of this study was to investigate whether twice-daily use of a rotating-oscillating power toothbrush (Oral-B Professional Care 1000(™) ) in nursing home (NH) residents over a 6-week period, compared to usual care (UC), would reduce periodontal inflammation. METHODS: In this repeated measures single-blinded randomized controlled trial, 59 residents of one NH in Winnipeg, Canada, were randomized to receive either twice-daily tooth brushing with a rotating-oscillating power toothbrush (PB) or UC by caregivers...
January 19, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/27752210/a-comparative-study-of-trigger-point-therapy-with-local-anaesthetic-0-5%C3%A2-bupivacaine-versus-combined-trigger-point-injection-therapy-and-levosulpiride-in-the-management-of-myofascial-pain-syndrome-in-the-orofacial-region
#12
Pranav Gupta, Virendra Singh, Sujata Sethi, Arun Kumar
AIM: To compare the efficacy of combined local anesthetic injection with 0.5 % bupivacaine and levosulpiride versus local anesthetic injection alone on outcome measures including levels of pain intensity and depression in the management of myofascial pain syndrome in orofacial region. PATIENTS AND METHODS: This was a prospective, randomized, controlled and open-label comparative clinical study. Seventy-four patients diagnosed to have myofascial pain syndrome and fulfilling the inclusion criteria were enrolled for the study...
September 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27612466/a-randomised-placebo-controlled-trial-assessing-the-efficacy-of-an-oral-b-group-vitamin-in-preventing-the-development-of-chemotherapy-induced-peripheral-neuropathy-cipn
#13
Janet M Schloss, Maree Colosimo, Caroline Airey, Paul Masci, Anthony W Linnane, Luis Vitetta
INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect resulting from neurotoxic chemotherapeutic agents. This study aimed to assess the efficacy and safety of an oral B group vitamin compared to placebo, in preventing the incidence of CIPN in cancer patients undergoing neurotoxic chemotherapy. METHODS: A pilot, randomised, placebo-controlled trial was conducted. Newly diagnosed cancer patients prescribed with taxanes, oxaliplatin or vincristine were invited to participate...
January 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27505989/potential-of-desensitizing-toothpastes-to-reduce-the-hydrogen-peroxide-diffusion-in-teeth-with-cervical-lesions
#14
Andrés Dávila-Sánchez, Andrés Fernando Montenegro, Arana-Gordillo Alfonso, Paulo Vitor Farago, Alessandro D Loguercio, Alessandra Reis
PURPOSE: To evaluate the occlusive potential of four toothpastes by atomic force microscopy (AFM) before and after bleaching and quantify the hydrogen peroxide (HP) diffusion into the pulp chamber after application of desensitizing toothpastes in teeth with cervical lesions. METHODS: In 52 human extracted premolars, 2-mm deep artificial cervical lesions (ACL) were prepared and rinsed with EDTA for 10 seconds. Then teeth were adapted in a brushing machine and brushed with one of the following toothpastes [Regular toothpaste with no occlusive compounds Colgate Cavity Protection (CP), Oral-B Pro Health (OB), Colgate ProRelief (PR) and Sensodyne Rapid Relief (RR)] under constant loading (250 g; 4...
June 2016: American Journal of Dentistry
https://www.readbyqxmd.com/read/27384682/laparoscopic-band-separated-one-anastomosis-gastric-bypass
#15
Oral B Ospanov
BACKGROUND: This video demonstrates laparoscopic band-separated one anastomosis gastric bypass-combining the advantages of banding and gastric bypass without stapler and cutter use. This is basically a gastrojejunal loop bypass above an obstructive band in the upper stomach. MATERIALS AND SURGICAL TECHNIQUE: An adjustable low pressure "Medsil" gastric band was introduced in the abdomen and retracted through the retrogastric tunnel. The front wall of the stomach below the band was displaced in the upward direction through the ring band, increasing the size of the anterior portion of the stomach pouch so that a gastroenteroanastomosis could be created at this point...
September 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27367193/-analysis-of-the-efficacy-and-safety-of-electric-toothbrushes-oral-b-with-oscillating-rotating-technology-in-%C3%A2-healthy-smile%C3%A2-program
#16
A I Nikolaev, N V Ginali, L M Tsepov, V R Shashmurina
The aim of study was to investigate the efficacy and safety of individual oral hygiene in adult patients by regular use of electric toothbrushes with the oscillating-rotating technology basing on data obtained during the implementation of «Healthy Smile» program. Questionnaires of 7022 dentists in Russia and Ukraine were used to assess personal experience of using Oral-B PC 5000 toothbrush. The dental status dynamics after regular use of Oral-B PC 500 tooth brush was evaluatedin 21 088 patients within 12 weeks...
2016: Stomatologii︠a︡
https://www.readbyqxmd.com/read/27122894/catecholaminergic-polymorphic-ventricular-tachycardia-a-rare-cause-of-cardiac-arrest-following-blunt-chest-trauma
#17
Isa Ozyilmaz, Sinem Ozyilmaz, Yakup Ergul, Celal Akdeniz, Volkan Tuzcu
UNLABELLED: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an electrophysiological disorder of a physically normal heart that occurs in children when the body is subjected to intense emotional or physical stress that causes adrenergic discharge. This troubling disease can be sporadic (spontaneous) or familial (genetic/inherited). Unfortunately, its associated ventricular tachycardia may cause sudden death, so early diagnosis of CPVT is very important. Treatment modalities include medical treatment, implantation of a cardioverter defibrillator, or surgical sympatectomy; but the implantable cardioverter defibrillator (ICD) should be the first choice in patients with a history of cardiac arrest...
July 2015: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27110254/antifungal-effects-of-common-mouthwashes-on-candida-strains-colonized-in-the-oral-cavities-of-liver-transplant-recipients-in-south-iran-in-2014
#18
Ali Dehghani Nazhvani, Pardis Haddadi, Parisa Badiee, Seyed Ali Malekhoseini, Hadis Jafarian
BACKGROUND: Among the opportunistic microorganisms, fungi, particularly Candida, play an important role in the mortality of transplant recipients. Thus, controlling and preventing fungal colonizations in various parts of the body, including the oral cavity, can reduce the possibility of post-transplant invasive fungal infections. This can be done simply by using mouthwashes. OBJECTIVES: The current study aimed to determine the prevalence of fungal species of Candida within the oral cavities of liver transplant recipients, and to evaluate the effects on Candida colonization of different exposure times to common mouthwashes...
January 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27097693/intralesional-versus-oral-chloroquine-in-cutaneous-leishmaniasis-comparison-of-outcome-duration-of-treatment-and-total-dose-of-drug
#19
RANDOMIZED CONTROLLED TRIAL
Malik Muhammad Hanif, Khizra Akram, Ghulam Mustafa
OBJECTIVE: To compare intralesional versus oral chloroquine in cutaneous leishmaniasis and determine the cure rate, duration of treatment, and total dose of drug. STUDY DESIGN: Randomized controlled study. PLACE AND DURATION OF STUDY: Department of Dermatology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, from November 2013 to June 2014. METHODOLOGY: Consecutive 86 patients of cutaneous leishmaniasis, with single to multiple lesions of various sizes were enrolled and divided randomly into group Aand B for the purpose of intralesional and oral chloroquine administration, respectively to compare the effect of the two routes on duration of treatment and total dose of the drug...
April 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27093772/stain-removal-efficacy-of-two-manual-toothbrushes
#20
RANDOMIZED CONTROLLED TRIAL
Lynn Roosa Friesen, Svetlana Farrell, Julie M Grender, Jill Underwood, Pam Cunningham, Renzo A Ccahuana-Vásquez
PURPOSE: To evaluate the dental stain removal efficacy of two commercially-available manual toothbrushes. METHODS: This was a randomized, examiner-blind, parallel-group, two treatment clinical trial of 2 weeks duration. Subjects qualifying for the study had a mean Modified Lobene Stain Index of ≥ 1.5 on at least two anterior teeth. Subjects were randomly allocated to one of two groups, receiving a test manual toothbrush (Oral-B 3D White Radiant) or a positive control (PC) manual brush to be used for 1 minute, twice daily for 2 weeks with a standard, anti-cavity fluoride dentifrice...
February 2016: American Journal of Dentistry
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