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Esophageal papillomas

Bilel Jideh, Martin Weltman, Yang Wu, Calvin H Y Chan
AIM: To determine the prevalence of esophageal squamous papillomas (ESPs) in a tertiary teaching hospital and to assess for any clinical associations, including relations with esophageal squamous cell carcinomas (SCCs). METHODS: Data from a total of 6962 upper gastrointestinal endoscopies over a five year period were retrospectively obtained and analysed. RESULTS: ESP was found in sixteen patients (0.23%). Eight (50%) patients had a high body mass index, seven (44%) had history of cigarette smoking...
April 16, 2017: World Journal of Clinical Cases
Shohei Ikoma, Marlo Nicolas, Jaishree Jagirdar, Maria Luisa Policarpio-Nicolas
Rare cases of metastatic squamous cell carcinoma with chondroid differentiation from esophageal primary have been reported but none from the uterine cervix. Given the rarity of this phenomenon and potential diagnostic pitfall, we present this unusual case. The patient is a 25-year-old woman who presented with shortness of breath. Computerized tomography (CT) showed several lung and pleural-based nodules. CT-guided core biopsy with touch preparations were performed on the pleural-based nodule. The touch preparations showed large, spindle-to-oval shaped cells with pleomorphic nuclei embedded in metachromatic chondroid stroma...
April 14, 2017: Diagnostic Cytopathology
Eric A Pasman, Theresa A Heifert, Cade M Nylund
Focal dermal hypoplasia (FDH) is a rare disorder of the mesodermal and ectodermal tissues. Here we present an eight-year-old female known to have FDH who presents with poor weight gain and dysphagia. She was diagnosed with multiple esophageal papillomas and eosinophilic esophagitis. She was successfully treated with argon plasma coagulation and ingested fluticasone propionate, which has not been described previously in a child.
March 28, 2017: World Journal of Gastroenterology: WJG
Qi Yang, Camelia Stefanovici, Quais Mujawar, Wael El-Matary
No abstract text is available yet for this article.
January 1, 2017: Pediatric and Developmental Pathology
Arzu Tiftikçi, Eser Kutsal, Ender Altıok, Ümit İnce, Bahattin Çicek, Murat Saruç, Nurten Türkel, Özdal Ersoy, Güven Yenmiş, Nurdan Tözün
BACKGROUND/AIMS: Human Papilloma Virus (HPV) infection can be a predisposing condition for the development of squamous cell papilloma (SCP) of the esophagus, which can progress to dysplasia and to carcinoma as a result of chronic infection. The aim of the present study was to search for the presence of HPV in the esophageal SCP, and to genotype the detected HPV. MATERIALS AND METHODS: Data from patients with definite diagnosis of SCP of the esophagus were identified from pathology records for two years period at different Hospitals...
May 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Andrew T Kunzmann, Suzanne Graham, Charlene M McShane, James Doyle, Massimo Tommasino, Brian Johnston, Jackie Jamison, Jacqueline A James, Damian McManus, Lesley A Anderson
BACKGROUND AND AIMS: Human papilloma virus (HPV), which may reach the esophagus through orogenital transmission, has been postulated to be associated with esophageal adenocarcinoma (EAC). A systematic review of the literature investigating the prevalence of infectious agents in EAC and Barrett's esophagus (BE) was carried out. METHODS: Using terms for viruses and EAC, the Medline, Embase, and Web of Science databases were systematically searched for studies published, in any language, until June 2016 that assessed the prevalence of viral agents in EAC or BE...
July 2017: European Journal of Gastroenterology & Hepatology
Isamu Suzuki, Young-Man Cho, Tadashi Hirata, Takeshi Toyoda, Jun-Ichi Akagi, Yasushi Nakamura, Eun Young Park, Azusa Sasaki, Takako Nakamura, Shigehisa Okamoto, Koji Shirota, Noboru Suetome, Akiyoshi Nishikawa, Kumiko Ogawa
To examine the effects of 4-methylthio-3-butenyl isothiocyanate on esophageal carcinogenesis, male 6-week-old F344 rats were subcutaneously injected with 0.5 mg/kg body weight N-nitrosomethylbenzylamine three times per week for 5 weeks and fed a diet supplemented with 80 ppm 4-methylthio-3-butenyl isothiocyanate, equivalent to 6.05 mg/kg body weight/day for the initiation stage, 4.03 mg/kg body weight/day for the promotion stage, or 4.79 mg/kg body weight/day for all stages. Although the incidence of lesions was not affected by 4-methylthio-3-butenyl isothiocyanate treatment, the multiplicity of squamous cell papilloma in the esophagus was significantly decreased in rats in the 4-methylthio-3-butenyl isothiocyanate initiation stage group (1...
October 2016: Journal of Toxicologic Pathology
Matjaž Homan, Mario Poljak, Nina Zidar
No abstract text is available yet for this article.
January 2017: Journal of Pediatrics
Yi-Wen Huang, Fei Gu, Alan Dombkowski, Li-Shu Wang, Gary D Stoner
Aberrant methylation of DNA is a common event in the development of cancers, including squamous cell carcinoma (SCC) of the human esophagus. In the present study, we determined: (a) whether aberrant DNA methylation also occurs in the development of N-nitrosomethylbenzylamine (NMBA)-induced tumorigenesis in the rat esophagus, a model of human esophageal SCC; and (b) if so, whether dietary black raspberries (BRBs) are capable of preventing this aberrant DNA methylation. A diet containing 5% BRBs inhibited the development of NMBA-induced tumors in the rat esophagus...
November 2016: Molecular Carcinogenesis
P U Prakash Saxena, Donald Jerard Fernandes, Mamidipudi Srinivasa Vidyasagar, Anshul Singh, Krishna Sharan
CONTEXT: To identify the incidence of human papilloma virus (HPV) infection in squamous esophageal cancer. AIMS: To identify high-risk (HR) HPV positivity rates in patients with squamous carcinoma esophagus and to compare their characteristics with HPV negative counterparts. SETTINGS AND DESIGN: A prospective study, in which tumor biopsies of 18 consecutive patients with squamous carcinoma of the esophagus treated with definitive chemo-radiotherapy (CT-RT) were evaluated for the presence of HPV...
April 2016: Journal of Cancer Research and Therapeutics
Alhareth M Al Juboori, Zeeshan Afzal, Nisar Ahmed
No abstract text is available yet for this article.
December 2015: Gastroenterology & Hepatology
Ganesh Pantham, Santhi Ganesan, Douglas Einstadter, Ge Jin, Aaron Weinberg, Ronnie Fass
BACKGROUND AND AIMS: There has been a recent increase in the incidence of oropharyngeal cancer (OPC) associated with high-risk human papilloma virus (HPV) infection. We investigated the incidence of esophageal papilloma and the presence of high-risk HPV infection. METHODS: This is a cross-sectional study conducted at a County teaching hospital. Patients with esophageal papilloma between January 2000 and December 2013 were identified. Patients with sufficient specimens were tested for the HPV virus...
January 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Ming-Wun Wong, Ming-Joug Bair, Shou-Chuan Shih, Cheng-Hsin Chu, Horng-Yuan Wang, Tsang-En Wang, Chen-Wang Chang, Ming-Jen Chen
AIM: To better understand some of the superficial tiny lesions that are recognized as squamous papilloma of the esophagus (SPE) and receive a different pathological diagnosis. METHODS: All consecutive patients with esophageal polypoid lesions detected by routine endoscopy at our Endoscopy Centre between October 2009 and June 2014 were retrospectively analysed. We enrolled patients with SPE or other superficial lesions to investigate four key endoscopic appearances (whitish color, exophytic growth, wart-like shape, and surface vessels) and used narrow band imaging (NBI) to distinguish their differences...
February 21, 2016: World Journal of Gastroenterology: WJG
Sarita Singhal, Robert D Baker, Abdur Khan, Susan S Baker, Daniel Gelfond, Razan H Alkhouri
No abstract text is available yet for this article.
October 2016: Clinical Pediatrics
Rajeev Kumar, Sankar Kumar Ghosh, Akalesh Kumar Verma, Anuradha Talukdar, Monoj Kumar Deka, Mira Wagh, H M Iqbal Bahar, Ritesh Tapkire, Kali Pankaj Chakraborty, R Ravi Kannan
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a common cancer in the north east of India. The present study concerned the prevalence of human papilloma virus (HPV) in the ESCC in north eastern India and its impact on response to chemotherapy. MATERIALS AND METHODS: p16 expression, a surrogate marker for HPV infection was assessed in 101 pre-treatment biopsies of locally advanced ESCC, reported from a comprehensive cancer centre in north east India, using immunohistochemistry...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Narges Mostafalou, Yousef Yahyapour, Sadegh Sedaghat, Javad Shokri Shirvani, Mahmoud HajiAhmadi, Sepideh Siadati, Shahriar Shafaei
BACKGROUND: Cancers are the second most common cause of non-accidental deaths in Iran, after cardiovascular mortality. Although most cases of esophageal squamous cell carcinoma (ESCC) in the USA and western populations have been attributed to high levels of exposure to tobacco and alcohol, but in Iranian populations, other risk factors especially infectious agents have been postulated as possible causes, particularly human papillomavirus (HPV). This study aimed to determine the prevalence and the types of HPV infection in biopsy samples taken from non-cancerous esophageal lesions during upper endoscopy...
2015: Caspian Journal of Internal Medicine
Sergio Estévez-Fernández, Raquel Sánchez-Santos, Esther Mariño-Padín, Sonia González-Fernández, Juan Turnes-Vázquez
INTRODUCTION: Given the difficulty in accessing to the excluded stomach after gastric bypass and the increase in gastroesophageal reflux after sleeve gastrectomy, it is justified to perform a preoperative fibrogastroscopy.The influence of the fibrogastroscopy (FGS) findings in the therapeutic approach is analyzed. PATIENTS AND METHODS: A retrospective study of preoperative FGS findings is performed, from 04/06 to 12/12. The influence of the FGS results on the surgical technique selection, in the endoscopic or medical treatment and its relation to gastric fistula is analyzed by means of multivariate regression (confounding factors: Age, body mass index, arterial hypertension, diabetes mellitus, antiplatelet therapy, surgical technique (bariatric surgery, sleeve gastrectomy)...
July 2015: Revista Española de Enfermedades Digestivas
Marie-Caroline d'Huart, Jean Baptiste Chevaux, Aude Marchal Bressenot, Nicolas Froment, Lucine Vuitton, Séverine Valmary Degano, Clotide Latarche, Marc André Bigard, Alain Courrier, Hervé Hudziak, Stéphane Koch, Eric Kull, Laurent Peyrin-Biroulet
BACKGROUND AND STUDY AIMS: Esophageal squamous papilloma (ESP) is a rare lesion. The aims of this study were to assess the prevalence of ESP in northeastern France and the risk of associated squamous cell carcinoma (SCC). PATIENTS AND METHODS: The charts of 78 patients who were diagnosed with ESP between January 2005 and February 2013 at three hospitals in northeastern France were reviewed. RESULTS: A total of 55 305 endoscopies were performed and 78 ESP were diagnosed (0...
April 2015: Endoscopy International Open
Zhaorui Lian, Eric K Lee, Adam J Bass, Kwok K Wong, Andres Jp Klein-Szanto, Anil K Rustgi, J Alan Diehl
Cyclin D1 is frequently overexpressed in esophageal squamous cell carcinoma (ESCC) and is considered a key driver of this disease. Mutations in FBXO4, F-box specificity factor that directs SCF-mediated ubiquitylation of cyclin D1, occur in ESCC with concurrent overexpression of cyclin D1 suggesting a potential tumor suppressor role for FBXO4. To evaluate the contribution of FBXO4-dependent regulation cyclin D1 in esophageal squamous cell homeostasis, we exposed FBXO4 knockout mice to N-nitrosomethylbenzylamine (NMBA), an esophageal carcinogen...
2015: Cancer Biology & Therapy
Kyoko Kawauchi, Chiaki Takahashi, Ryoko Ishihara, Shinichi Hatama
A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was developed to detect and type bovine papillomaviruses (BPVs) from tumors in cattle. Two degenerate primer sets targeting the BPV L1 gene, subAup/subAdw and subBup/subBdw, and one restriction enzyme RsaI were used in this assay. In silico analyses of the restriction enzyme sites in the PCR fragments of 13 BPV sequences (BPV-1 to -13) revealed that all known BPVs are differentiated by the PCR-RFLP assay. Analyses of 63 previously typed clinical samples, that included teat papillomas and both esophageal and urinary bladder cancer biopsies, show that the assay clearly differentiates between eight clinically important BPV types (BPV-1 to -6, -9, -10), and discriminates between single and multiple infections...
June 15, 2015: Journal of Virological Methods
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