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Christine Culpepper, Kendra Hendrickson, Susan Marshall, Jessica Benes, Theresa R Grover
BACKGROUND: Growth and nutrition are critical in neonatal care. Whether feeding guidelines improve growth and nutrition and reduce morbidity is unknown. PURPOSE: Feeding guidelines for very low birth-weight (VLBW) infants were implemented in our neonatal intensive care unit (NICU) to start and achieve full enteral feeds sooner, and increase weight gain over the first month. METHODS: Feeding guidelines for VLBW infants were implemented in January 2014, stratified by birth weight (<750, 750-1000, and 1000-1500 g)...
October 7, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Daxu Li, Rong Chen, Shin-Ho Chung
Tertiapin (TPN), a short peptide isolated from the venom of the honey bee, is a potent and selective blocker of the inward rectifier K(+) (Kir) channel Kir3.2. Here we examine in atomic detail the binding mode of TPN to Kir3.2 using molecular dynamics, and deduce the key residue in Kir3.2 responsible for TPN selectivity. The binding of TPN to Kir3.2 is stable when the side chain of either Lys16 (TPN(K16)-Kir3.2) or Lys17 (TPN(K17)-Kir3.2) of the toxin protrudes into the channel pore. However, the binding affinity calculated from only TPN(K17)-Kir3...
September 30, 2016: Biophysical Chemistry
Mei Yang, Yijiang Liu, Hongbiao Chen, Duanguang Yang, Huaming Li
Metal-free N-doped carbon (NC) materials have been regarded as one of the most promising catalysts for the oxygen reduction reaction (ORR) in alkaline media because of their outstanding ORR catalytic activity, high stability, and good methanol tolerance. Up to now, only a small minority of such catalysts have been synthesized from triazine-based polymeric networks. Herein, we report the synthesis of such NC catalyst by directly pyrolyzing a nitrogen-rich, triazine-based polypyrrole network (TPN). The TPN is fabricated by oxidative polymerization of 2,4,6-tripyrrol-1,3,5-triazine monomer using TfOH as the protonating agent and benzoyl peroxide as the oxidizing agent...
October 7, 2016: ACS Applied Materials & Interfaces
Vigdis Staven, Herra Iqbal, Siri Wang, Ingrid Grønlie, Ingunn Tho
OBJECTIVES: Infusion of precipitate or destabilized emulsion can be harmful. The purpose of this study was to obtain Y-site compatibility data on intravenous drugs and total parenteral nutrition (TPN) relevant for children. METHODS: Two three-in-one TPN admixtures (Olimel N5E and Numeta G16E) used for children of different age groups were tested with ten drugs (ampicillin, ceftazidime, clindamycin, dexamethasone, fluconazole, fosphenytoin, furosemide, metronidazole, ondansetron and paracetamol)...
October 7, 2016: Journal of Pharmacy and Pharmacology
Jarosław Szefel, Wiesław J Kruszewski, Mariusz Szajewski, Maciej Ciesielski, Ewa Sobczak, Maksymilian Czerepko, Wiesława Łysiak-Szydłowska
INTRODUCTION: Currently there are no established guidelines regarding the use of long-chain triglycerides (LCT) vs. medium-chain triglycerides medium-chain triglycerides (MCT)/long-chain triglycerides (LCT) in total parenteral nutrition (TPN). Severe malnutrition of patients with refractory cachexia (RC) often causes their disqualification from invasive methods of treatment thus decreasing their quality of life and survival time. AIM: To compare the changes in nutritional state of patients with RC receiving PN with LCT and LCT/MCT lipid emulsions and to assess the influence of enteral nutrition on their survival time...
2016: Przegla̜d Gastroenterologiczny
Gaurav Pahouja, Kalpit Patel, Daniel J Ricchiuti
OBJECTIVE: The aim of the study was to present a case series of the sparsely reported complication of chylous ascites (CA) after left sided robot-assisted laparoscopic partial nephrectomy (RALPN), identify possible risk factors for the development of postoperative CA, and explore current recommendations for identification, management and prevention of CA. MATERIAL AND METHODS: A retrospective review of patients that were treated with a RALPN during a one year time period (August 2012 to August 2013) by one surgeon at our institution was conducted...
October 5, 2016: Archivio Italiano di Urologia, Andrologia
DongFei Li, KeWei Zhang, MingXing Song, NaiCui Zhai, ChengLin Sun, HaiBo Li
The in situ high-pressure Raman spectra of Terephthalonitrile (TPN) have been investigated from ambient to 12.6GPa at room temperature. All the fundamental vibrational modes of TPN at ambient were assigned based on the first-principle calculations. A detailed Raman spectroscopy analysis revealed that TPN underwent a phase transition at ~5.3GPa. The frequencies of the TPN Raman peaks increase with increasing the pressure which can be attributed to the reduction in the interatomic distances and the escalation of effective force constants...
September 28, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Rodrigo Barboza Nunes, Bruno Francisco Müller, Federico Enrique Garcia Cipriano, Pedro Soler Coltro, Jayme Adriano Farina
Treatment of bronchial fistula (BF) after pulmonary lobectomy is a challenge. Often, patients require long hospital stay, have recurrent empyema and pneumonia, are susceptible to sepsis, often need broad-spectrum antibiotics, as well as various surgical approaches. With the advent and growing evidence of the benefits of negative pressure therapy (NPT), its use in some patients with BF has been reported with encouraging results concerning its feasibility and cost-effectiveness. The aim of this study was to demonstrate the application of NPT as a resource for BF treatment and comparatively analyze the overall cost of treatment...
July 2016: Revista do Colégio Brasileiro de Cirurgiões
Ladda Kajeechiwa, May Myo Thwin, Paw Wah Shee, Nan Lin Yee, Elvina Elvina, Peapah Peapah, Kyawt Kyawt, Poe Thit Oo, William PoWah, Jacqueline Roger Min, Jacher Wiladphaingern, Lorenz von Seidlein, Suphak Nosten, Francois Nosten
BACKGROUND: A targeted malaria elimination project, including mass drug administrations (MDA) of dihydroartemisinin/piperaquine plus a single low dose primaquine is underway in villages along the Thailand Myanmar border. The intervention has multiple components but the success of the project will depend on the participation of the entire communities. Quantitative surveys were conducted to study reasons for participation or non-participation in the campaign with the aim to identify factors associated with the acceptance and participation in the mass drug administrations...
September 27, 2016: Malaria Journal
Shun Onishi, Tatsuru Kaji, Waka Yamada, Kazuhiko Nakame, Tomoe Moriguchi, Koushirou Sugita, Koji Yamada, Takafumi Kawano, Motoi Mukai, Masakazu Souda, Sohsuke Yamada, Takako Yoshioka, Akihide Tanimoto, Satoshi Ieiri
PURPOSE: Long-term parenteral nutrition following massive bowel resection causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). IFALD includes two different states, cholestasis and steatosis, which represents a life-threatening complication. The previous reports have shown the protective role of ghrelin in the liver. The aim of this study was to evaluate the effects of the administration of ghrelin in the liver in a parenterally fed rat model of short bowel syndrome (SBS)...
September 20, 2016: Pediatric Surgery International
Beathe Haatveit, Jimmy Jensen, Dag Alnæs, Tobias Kaufmann, Christine L Brandt, Christian Thoresen, Ole A Andreassen, Ingrid Melle, Torill Ueland, Lars T Westlye
BACKGROUND: Schizophrenia is associated with cognitive impairment and brain network dysconnectivity. Recent efforts have explored brain circuits underlying cognitive dysfunction in schizophrenia and documented altered activation of large-scale brain networks, including the task-positive network (TPN) and the task-negative default mode network (DMN) in response to cognitive demands. However, to what extent TPN and DMN dysfunction reflect overlapping mechanisms and are dependent on cognitive state remain to be determined...
2016: NeuroImage: Clinical
Nan Lan, Bo Shen, Lisi Yuan, Xiuli Liu
BACKGROUND: Collagenous sprue (CS) is a rare form of enteropathy that had been reported to be associated with celiac disease (CD) and collagenous colitis (CC). The aim of our study was to compare the clinical features, treatments and outcomes of CS, CD, and CC. METHODS: All patients with histologic diagnosis of CS, CD or CC with complete clinical data were extracted from our pathology database between 1990 and 2015. Demographic and clinical features were recorded along with treatments and outcomes...
September 13, 2016: Journal of Gastroenterology and Hepatology
Matthew W Ralls, Farokh Rustom Demehri, Yongjia Feng, Sasha Raskind, Chunhai Ruan, Arno Schintlmeister, Alexander Loy, Buck Hanson, David Berry, Charles F Burant, Daniel H Teitelbaum
BACKGROUND: Total parenteral nutrition (TPN) leads to a shift in small intestinal microbiota with a characteristic dominance of Proteobacteria. This study examined how metabolomic changes within the small bowel support an altered microbial community in enterally deprived mice. METHODS: C57BL/6 mice were given TPN or enteral chow. Metabolomic analysis of jejunal contents was performed by liquid chromatography/mass spectrometry (LC/MS). In some experiments, leucine in TPN was partly substituted with (13)C-leucine...
September 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
Murat Konak, Nuriye Tarakci, Hüseyin Altunhan, Ali Annagür, Aysun Toker, Rahmi Örs
OBJECTIVE: The aim of our study was to determine whether lipid solutions delivered separately or in mixture with total parenteral nutrition (TPN) solutions effect the balance between oxidant and antioxidant levels in premature infants. METHODS: A total of 60 preterm newborns who were delivered at their 30-34 gestational weeks and received TPN were included in the study. Premature newborns were randomized into two groups based on the delivery method of the lipid solution, separately (Group 1) or in mixture with TPN solutions (Group 2)...
September 1, 2016: Journal of Maternal-fetal & Neonatal Medicine
T Hang Nghiem-Rao, Allison F Dahlgren, Deepti Kalluri, Yumei Cao, Pippa M Simpson, Shailendra B Patel
BACKGROUND: Premature and critically ill infants receiving total parenteral nutrition (TPN) are at risk for dyslipidemia, and altered cholesterol levels in early life may contribute to later cardiovascular risk. Data regarding plasma cholesterol response to TPN in young infants are lacking. OBJECTIVE: To determine the changes in plasma cholesterol levels during the first week of life in infants receiving TPN and a comparison group of infants who did not receive TPN during routine care...
July 2016: Journal of Clinical Lipidology
Jinshun Xu, Yu Chen, Liming Deng, Jianxin Liu, Yang Cao, Pan Li, Haitao Ran, Yuanyi Zheng, Zhigang Wang
The fast development of nanotechnology has provided a new efficient strategy for enhancing the therapeutic efficiency of various treatment modalities against cancer. However, the improvement of minimally invasive microwave therapy based on nanomaterials has not been realized. In this work, we successfully designed and synthesized a novel folate-targeted nanodroplet (TPN) with a composite mixture of perfluorocarbons as the core and lipid as the shell, which exerts the distinctive dual functions as the adjuvant for highly efficient percutaneous ultrasound imaging-guided microwave ablation (MWA) of tumors...
November 2016: Biomaterials
Chao Wu, Xinying Wang, Tingting Jiang, Chaojun Li, Li Zhang, Xuejin Gao, Feng Tian, Ning Li, Jieshou Li
BACKGROUND AND AIMS: This study was designed to investigate a relatively optimum dose of partial enteral nutrition (PEN) which effectively attenuates intestinal barrier dysfunction initiated by ischemia/reperfusion injury (IRI). METHODS: In experiment 1, 60 male Sprague-Dawley (SD) rats were subjected to intestinal IRI and assigned to six groups according to the different proportion of EN administrations: namely total parenteral nutrition (TPN or 0%EN), 10%EN, 20%EN, 40%EN, 60%EN, and total enteral nutrition (TEN or 100%) groups, the deficits of intraluminal calorie were supplemented by PN...
2016: Nutrients
Diarmaid Semple, Moninne Howlett
AIM: Since the discontinuation of a commercially available liquid calcium medicine, there have been various local strategies to obtain adequate calcium levels, particularly in suspected 22Q11.2 deletion syndrome children post cardiothoracic surgery. Pharmacy obtained on special order a Calcium Liquid food supplement (0.5 mmol calcium/ml) for use in those children whom effervescent tablets did not appear to improve corrected calcium. Anecdotally it was thought that calcium liquid was better tolerated and absorbed, resulting in quicker recovery time of corrected calcium than use of the effervescent tablets...
September 2016: Archives of Disease in Childhood
Günhan Gökahmetoğlu, Fatma Mutlu Sarıgüzel, Ayşe Nedret Koç, Orhan Behret, Selma Gökahmetoğlu, Mustafa Altay Atalay, Ferhan Elmalı, Kamil Darçın
The colonization rate of Candida spp. reaches up to 80% in patients who reside in intensive care units (ICUs) more than a week, and the mean rate of development of invasive disease is 10% in colonized patients. Since invasive candidiasis (IC) in ICU patients presents with septic shock and high mortality rate, rapid diagnosis and treatment are crucial. The aim of this study was to assess the relationship between invasive infection and the determination of Candida colonization index (CI) and Candida score (CS) in patients admitted to ICU who are at high risk for IC and likely to benefit from early antifungal therapy...
July 2016: Mikrobiyoloji Bülteni
Lusine Ambartsumyan, Alejandro Flores, Samuel Nurko, Leonel Rodriguez
OBJECTIVES: Chronic intestinal pseudo-obstruction (CIPO) is a challenging disorder with high morbidity and mortality due to limited effective therapies that improve enteral tolerance. We aimed to present our experience using octreotide in children with CIPO and evaluate factors predicting therapy response. METHODS: The study population included total parenteral nutrition (TPN)-dependent children with CIPO receiving octreotide at a tertiary care center. Octreotide response was defined as an enteral feeding increase of ≥10 cc/kg/day...
October 2016: Paediatric Drugs
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