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https://www.readbyqxmd.com/read/28214831/p38-mapk-pharmacological-inhibitor-sb203580-alleviates-total-parenteral-nutrition-induced-loss-of-intestinal-barrier-function-but-promotes-hepatocyte-lipoapoptosis
#1
Yong-Tao Xiao, Wei-Hui Yan, Yi Cao, Jun-Kai Yan, Wei Cai
BACKGROUND & AIMS: Our previous studies have provided evidence that p38 mitogen-activated protein kinase (MAPK) is involved in total parenteral nutrition (TPN)-associated complications, but its exact effects and mechanisms have not been fully understood. This study aimed to evaluate the roles of p38 MAPK inhibitor SB203580 in the TPN-induced loss of intestinal barrier function and liver disease. METHODS: A rodent model of TPN was used to analyze the roles of SB203580 in TPN-associated complications...
February 8, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28188037/determinants-of-outcomes-in-patients-with-simple-gastroschisis
#2
Fouad Youssef, Jean-Martin Laberge, Pramod Puligandla, Sherif Emil
PURPOSE: We analyzed the determinants of outcomes in simple gastroschisis (GS) not complicated by intestinal atresia, perforation, or necrosis. METHODS: All simple GS patients enrolled in a national prospective registry from 2005 to 2013 were studied. Patients below the median for total parenteral nutrition (TPN) duration (26days) and hospital stay (34days) were compared to those above. Univariate and multivariate logistic and linear regression analyses were employed using maternal, patient, postnatal, and treatment variables...
January 28, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28183624/hierarchical-surface-patterning-of-ni-and-be-free-ti-and-zr-based-bulk-metallic-glasses-by-thermoplastic-net-shaping
#3
Baran Sarac, Supriya Bera, Sascha Balakin, Mihai Stoica, Mariana Calin, Jürgen Eckert
In order to establish a strong cell-material interaction, the surface topography of the implant material plays an important role. This contribution aims to analyze the formation kinetics of nickel and beryllium-free Ti- and Zr-based Bulk Metallic Glasses (BMGs) with potential biomedical applications. The surface patterning of the BMGs is achieved by thermoplastic net-shaping (TPN) into anisotropically etched cavities of silicon chips. The forming kinetics of the BMG alloys is assessed by thermal and mechanical measurements to determine the most suitable processing temperature and time, and load applied...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28178582/short-term-weight-gain-velocity-in-infants-with-congenital-diaphragmatic-hernia-cdh
#4
Jason Gien, Karna Murthy, Eugenia K Pallotto, Beverly Brozanski, Louis Chicoine, Isabella Zaniletti, Ruth Seabrook, Sarah Keene, Deepthi Alapati, Nicolas Porta, Natalie Rintoul, Theresa R Grover
BACKGROUND: Appropriate post-natal growth remains a mainstay of therapeutic goals for infants with CDH, with the hypothesis that optimizing linear growth will improve survival through functional improvements in pulmonary hypoplasia. However, descriptions of growth and the effect on survival are limited in affected infants. OBJECTIVE: Describe in-hospital weight gain related to survival among infants with CDH. DESIGN/METHODS: Children's Hospitals Neonatal Database (CHND) identified infants with CDH born ≥34weeks' gestation (2010-14)...
February 5, 2017: Early Human Development
https://www.readbyqxmd.com/read/28168989/pediatric-surgical-capacity-in-africa-current-status-and-future-needs
#5
Asra Toobaie, Sherif Emil, Doruk Ozgediz, Sanjay Krishnaswami, Dan Poenaru
BACKGROUND: African pediatric surgery (PS) faces multiple challenges. Information regarding existing resources is limited. We surveyed African pediatric surgeons to determine available resources and clinical, educational, and collaborative needs. METHODS: Members of the Pan-African Pediatric Surgical Association (PAPSA) and the Global Pediatric Surgery Network (GPSN) completed a structured email survey covering PS providers, facilities, resources, workload, education/training, disease patterns, and collaboration priorities...
January 29, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28164781/long-range-projection-neurons-in-the-taste-circuit-of-drosophila
#6
Heesoo Kim, Colleen Kirkhart, Kristin Scott
Taste compounds elicit innate feeding behaviors and act as rewards or punishments to entrain other cues. The neural pathways by which taste compounds influence innate and learned behaviors have not been resolved. Here, we identify three classes of taste projection neurons (TPNs) in Drosophila melanogaster distinguished by their morphology and taste selectivity. TPNs receive input from gustatory receptor neurons and respond selectively to sweet or bitter stimuli, demonstrating segregated processing of different taste modalities...
February 6, 2017: ELife
https://www.readbyqxmd.com/read/28162766/outcome-prediction-in-gastroschisis-the-gastroschisis-prognostic-score-gps-revisited
#7
Pramod S Puligandla, Robert Baird, Eric D Skarsgard, Sherif Emil, Jean-Martin Laberge
PURPOSE: The GPS enables risk stratification for gastroschisis and helps discriminate low from high morbidity groups. The purpose of this study was to revalidate GPS's characterization of a high morbidity group and to quantify relationships between the GPS and outcomes. METHODS: With REB approval, complete survivor data from a national gastroschisis registry was collected. GPS bowel injury scoring was revalidated excluding the initial inception/validation cohorts (>2011)...
January 27, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28153691/effortful-control-and-resting-state-networks-a-longitudinal-eeg-study
#8
Gennady G Knyazev, Alexander N Savostyanov, Andrey V Bocharov, Helena R Slobodskaya, Nadezhda B Bairova, Sergey S Tamozhnikov, Valentina V Stepanova
Resting state networks' (RSNs) architecture is well delineated in mature brain, but our understanding of their development remains limited. Particularly, there are few longitudinal studies. Besides, all existing evidence is obtained using functional magnetic resonance imaging (fMRI) and there are no data on electrophysiological correlates of RSN maturation. We acquired three yearly waves of resting state EEG data in 80 children between 7 and 9years and in 55 adults. Children's parents filled in the Effortful Control (EC) scale...
January 30, 2017: Neuroscience
https://www.readbyqxmd.com/read/28149146/antifungal-susceptibility-and-risk-factors-in-patients-with-candidemia
#9
Cigdem Mermutluoglu, Ozcan Deveci, Saim Dayan, Emel Aslan, Fatma Bozkurt, Recep Tekin
OBJECTIVE: This study aimed to investigate the antifungal susceptibility, typology, and risk factors of candidemia among adult and pediatric inpatients at a university hospital. MATERIALS AND METHODS: A case-control study was designed, and data collected between December 2013 and December 2014 were retrospectively evaluated. The case group consisted of patients with candidemia. The control group was selected from the inpatients that did not develop candidemia but were admitted in the same clinic and during the same period as the candidemia group...
October 2016: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28147371/crohn-s-disease-and-intestinal-transplantation
#10
Pavel Drastich, Martin Oliverius
BACKGROUND: Most patients with Crohn's disease (CD) require one or more operations during their lifetime. Repeated resections and surgical complications may result in short gut in a subset of patients, typically those with extensive small bowel disease or a penetrating CD phenotype. The effects of short bowel syndrome (SBS) can range in seriousness from mild to life-threatening advanced intestinal failure. Worldwide, CD is the second leading indication for intestinal transplantation (ITx) in SBS, but the overall incidence of ITx is quite low...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28146184/-exposition-to-total-parenteral-nutrition-increases-the-risk-of-catheter-related-bloodstream-infection
#11
Teresa Vergara, Elena Véliz, Alberto Fica
BACKGROUND: Infectious complications associated to central venous catheter (CVC) increase morbidity, mortality and costs. Total parenteral nutrition (TPN) is one of the risk factors described for catheter-related bloodstream infection (CR-BSI). The aim of this study was explore if TPN and time of exposition, are risk factors for CR-BSI among patient exposed to this therapy. PATIENTS AND METHODS: Cohort study of patients with CVC exposed and not exposed to TPN with calculation of the relative risk (RR) for CR-BSI and percentage of CR-BSI according to different times of exposition to TPN...
December 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28128283/a-uk-wide-cohort-study-describing-management-and-outcomes-for-infants-with-surgical-necrotising-enterocolitis
#12
Benjamin Allin, Anna-May Long, Amit Gupta, Marian Knight, Kokila Lakhoo
The Royal College of Surgeons have proposed using outcomes from necrotising enterocolitis (NEC) surgery for revalidation of neonatal surgeons. The aim of this study was therefore to calculate the number of infants in the UK/Ireland with surgical NEC and describe outcomes that could be used for national benchmarking and counselling of parents. A prospective nationwide cohort study of every infant requiring surgical intervention for NEC in the UK was conducted between 01/03/13 and 28/02/14. Primary outcome was mortality at 28-days...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28118819/short-bowel-syndrome-results-in-increased-gene-expression-associated-with-proliferation-inflammation-bile-acid-synthesis-and-immune-system-activation-rna-sequencing-a-zebrafish-sbs-model
#13
Kathy A Schall, Matthew E Thornton, Mubina Isani, Kathleen A Holoyda, Xiaogang Hou, Ching-Ling Lien, Brendan H Grubbs, Tracy C Grikscheit
BACKGROUND: Much of the morbidity associated with short bowel syndrome (SBS) is attributed to effects of decreased enteral nutrition and administration of total parenteral nutrition (TPN). We hypothesized that acute SBS alone has significant effects on gene expression beyond epithelial proliferation, and tested this in a zebrafish SBS model. METHODS: In a model of SBS in zebrafish (laparotomy, proximal stoma, distal ligation, n = 29) or sham (laparotomy alone, n = 28) surgery, RNA-Seq was performed after 2 weeks...
January 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28089677/global-signal-regression-acts-as-a-temporal-downweighting-process-in-resting-state-fmri
#14
Alican Nalci, Bhaskar D Rao, Thomas T Liu
In resting-state functional MRI (rsfMRI), the correlation between blood oxygenation level dependent (BOLD) signals across different brain regions is used to estimate the functional connectivity of the brain. This approach has led to the identification of a number of resting-state networks, including the default mode network (DMN) and the task positive network (TPN). Global signal regression (GSR) is a widely used pre-processing step in rsfMRI that has been shown to improve the spatial specificity of the estimated resting-state networks...
January 9, 2017: NeuroImage
https://www.readbyqxmd.com/read/28088773/epidemiology-and-outcome-of-acute-pancreatitis-in-end-stage-renal-disease-dialysis-patients-a-10-year-national-cohort-study
#15
Hung-Jui Chen, Jhi-Joung Wang, Wen-Ing Tsay, Shwu-Huey Her, Cheng-Heng Lin, Chih-Chiang Chien
BACKGROUND: The objective of this study is to determine the incidence and severity of acute pancreatitis (AP) in patients with end-stage renal disease (ESRD) on dialysis and whether the dialysis modality [hemodialysis (HD) versus peritoneal dialysis (PD)] confers a higher risk for AP as well as complications or mortality related to AP. METHODS: We analyzed national health insurance claims data of 67 078 ESRD patients initiating dialysis between 1999 and 2007 in Taiwan...
January 14, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28051047/evaluation-of-the-use-of-laparoscopic-guided-cholecystocholangiography-and-liver-biopsy-in-definitive-diagnosis-of-neonatal-cholestatic-jaundice
#16
Khalid Shreef, Abdullah Alhelal
BACKGROUND: Once it is established that a jaundiced infant has direct hyperbilirubinemia, the principal diagnostic concern is to differentiate hepatocellular from obstructive cholestasis. Traditional tests such as ultrasonography, percutaneous liver biopsy and technetium 99 m hepatobiliary iminodiacetic acid (HIDA) scan are often not sufficiently discriminating. Definitive exclusion of biliary atresia (BA) in the infant with cholestatic jaundice usually requires mini-laparotomy and intra-operative cholangiography...
October 2016: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/28033194/neonatal-soft-tissue-reconstruction-using-a-bioengineered-skin-substitute
#17
Scott D Hirsch, Jeremy M Powers, Jennifer L Rhodes
Total parenteral nutrition (TPN) can be a lifesaving intervention for premature neonates and it is often delivered through peripheral access in this unique population. However, extravasation and tissue damage can result. Current literature lacks strong evidence regarding the treatment and reconstruction of such injuries in this age group. The authors present a patient with a 30-week gestational age premature newborn whom suffered an extravasation injury with peripherally administered TPN leading to full thickness skin and soft tissue necrosis of the dorsum of the right hand...
December 28, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28017414/improved-outcomes-for-inborn-babies-with-uncomplicated-gastroschisis
#18
B G Dalton, K W Gonzalez, S R Reddy, R J Hendrickson, C W Iqbal
INTRODUCTION: Gastroschisis (GS) is a common abdominal wall defect necessitating neonatal surgery and intensive care. We hypothesized that inborn patients had improved outcomes compared to patients born at an outside hospital (outborn) and transferred for definitive treatment. METHODS: A single center, retrospective chart review at a pediatric tertiary care center was performed from 2010 to 2015. All patients whose primary surgical treatment of GS was performed at this center were included...
December 18, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28011968/extended-spectrum-beta-lactamase-producing-enterobacteriaceae-among-the-pediatric-population-who-is-at-risk-and-why-results-from-a-single-centre-prospective-study
#19
Carmelina Calitri, Carlo Scolfaro, Sara Colombo, Gianfranco De Intinis, Francesca Carraro, Silvia Garazzino, Pier-Angelo Tovo
A prospective 18-month case-control study was performed in a tertiary Paediatric Centre in Turin (Italy) to analyse the disease burden and identify risk factors for acquisition of Extended Spectrum Beta Lactamase-producing Enterobacteriaceae (ESBL-pE). Children with ESBL-pE isolation were enrolled as cases, with controls matched according to age, type of pathogen isolated and sample of isolation. Out of 83 children (37 males, mean age 4.7 ± 5.46 years), 45 were identified as infected (54.2%) and 38 as colonised (45...
1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28004315/bioflavonoid-fisetin-loaded-%C3%AE-tocopherol-poly-lactic-acid-based-polymeric-micelles-for-enhanced-anticancer-efficacy-in-breast-cancers
#20
Lei Wang, De-Zhong Zhang, Yu-Xia Wang
PURPOSE: In this study, tocopherol based polymeric micelles were successfully prepared to enhance the anticancer effect of fisetin (FIS) in breast cancer cells. METHODS: The drug-loaded carrier was characterized in terms of physicochemical and in vivo parameters. RESULTS: Compared to FIS, FIS-TPN showed higher cellular uptake in MCF-7 breast cancer cells as revealed by CLSM and flow cytometry. The cytotoxicity assay results clearly showed that the free FIS and FIS-TPN exhibited a typical dose-dependent toxic effect in MCF-7 breast cancer cells...
December 21, 2016: Pharmaceutical Research
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