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https://www.readbyqxmd.com/read/28087825/incidence-and-predictors-of-epilepsy-after-pediatric-arterial-ischemic-stroke
#1
Lori L Billinghurst, Lauren A Beslow, Nicholas S Abend, Michael Uohara, Laura Jastrzab, Daniel J Licht, Rebecca N Ichord
OBJECTIVE: To determine the cumulative incidence and clinical predictors of remote symptomatic seizures and epilepsy after pediatric arterial ischemic stroke (AIS). METHODS: We performed a retrospective analysis of 218 participants with neonatal AIS (NAIS), presumed perinatal AIS (PPAIS), and childhood AIS (CAIS) from a single-center prospective consecutive cohort enrolled from 2006 to 2014. Medical records were reviewed for timing, semiology, and treatment of acute symptomatic seizures, remote symptomatic seizures (RSS), and epilepsy...
January 13, 2017: Neurology
https://www.readbyqxmd.com/read/28034814/outcome-prognostic-factors-and-follow-up-results-after-subarachnoid-hemorrhage-from-pericallosal-artery-aneurysms
#2
Nazife Dinc, Stephanie Lescher, Johanna Quick-Weller, Joachim Berkefeld, Johannes Platz, Christian Senft, Volker Seifert, Juergen Konczalla
OBJECTIVE: Pericallosal artery aneurysms (PAA) are usually rare (2-5%) and treatment is challenging for both modalities, surgical and endovascular. The authors performed this analysis to determine the outcome and prognostic factors after subarachnoidal hemorrhage due to ruptured pericallosal artery aneurysms. MATERIALS AND METHODS: A total of 32 patients with ruptured PAA were admitted to our hospital between 1999 and 2014, added to our prospective database and analyzed retrospectively...
December 26, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28017208/subjective-hearing-impairment-after-subarachnoid-haemorrhage-prevalence-and-risk-factors
#3
Erik M Vos, Paut Greebe, J M Anne Visser-Meily, Gabriel J E Rinkel, Mervyn D I Vergouwen
BACKGROUND: Sensorineural hearing impairment is a key symptom in patients with superficial siderosis of the central nervous system, a disease caused by chronic or intermittent haemorrhage into the subarachnoid space. We investigated the prevalence and risk factors of subjective hearing impairment after SAH. METHODS: We systematically interviewed all SAH patients admitted between June 2011 and December 2014, who were able to visit the SAH outpatient clinic six to eight weeks after hospital discharge...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28011358/anticoagulation-therapy-in-patients-suffering-from-aneurysmal-subarachnoid-hemorrhage-influence-on-functional-outcome-a-single-center-series-and-multivariate-analysis
#4
Patrick Schuss, Alexis Hadjiathanasiou, Simon Brandecker, Ági Güresir, Valeri Borger, Christian Wispel, Hartmut Vatter, Erdem Güresir
INTRODUCTION: Favourable outcome in patients presenting with aneurysmal subarachnoid hemorrhage (SAH) is determined by several factors. Nevertheless, data on the influence of prior use of oral anticoagulation drugs on functional outcome in patients suffering from SAH is scarce. We therefore analyzed our institutional data. METHODS: From January 2009 to October 2015, 480 patients suffering from aneurysmal SAH were admitted to our institution. Information, including patient characteristics, treatment modality, aneurysm size and location, radiological features, and functional neurological outcome were assessed and further analyzed...
December 21, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27993743/time-is-brain-analysis-of-245-cases-with-decompressive-craniectomy-due-to-subarachnoid-hemorrhage
#5
Ramazan Jabbarli, Marvin Darkwah Oppong, Philipp Dammann, Karsten H Wrede, Nicolai El Hindy, Neriman Özkan, Oliver Müller, Michael Forsting, Ulrich Sure
OBJECTIVE: Decompressive craniectomy (DC) may become a life-saving measure for patients with subarachnoid hemorrhage (SAH). However, the benefit of early DC has not been shown yet. We aimed at identifying the clinical value of DC timing. METHODS: We retrospectively analyzed 245 SAH patients who underwent DC between January 2003 and December 2015. The cohort was stratified into primary (at admission, n=171) and secondary DC (n=74). Moreover, primary DC was also subdivided into early (≤24 hours after ictus, n=120) and delayed (n=51) primary DC...
December 16, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27971386/estimating-the-economic-burden-associated-with-the-early-stages-of-progression-of-alzheimer-s-disease-in-europe
#6
P Lindgren, L Jönsson, F Coste, E Chan, R Bosshard, For The Ictus/Dsa Study Group
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27966299/cognitive-impairment-one-year-after-ischemic-stroke-predictorsand-dynamics-of-significant-determinants
#7
Margarita Lubomirova Alexandrova, Maya Penkova Danovska
BACKGROUND/AIM: Evidence suggests that the risk for dementia increases after stroke. This study investigated the dynamics of the neurological and cognitive status of patients with no baseline dementia over a 1-year period after ischemic stroke. MATERIALS AND METHODS: We examined 47 ischemic stroke patients admitted within 48 h of ictus. Their neurological and cognitive statuses, blood biochemical parameters, and microalbuminuria levels were prospectively evaluated over a 1-year period post-stroke...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27965078/a-high-resolution-analysis-on-the-meteorological-influences-on-spontaneous-intracerebral-hemorrhage-incidence
#8
Marian Christoph Neidert, Michael Sprenger, Marius Mader, Giuseppe Esposito, Jonas Aurel Hosp, Oliver Bozinov, Luca Regli, Jan-Karl Burkhardt
OBJECTIVE: To investigate the influence of meteorological factors on the incidence of intracerebral hemorrhage (ICH). METHODS: We included 295 ICH admissions between 2005 and 2013. The hourly meteorological parameters considered are: surface pressure, temperature, relative humidity, wind gusts and precipitation. To minimize confounding effects of seasonality, data were analyzed using the following three complementary statistical approaches: (i) deviation of daily measure from the 10-year monthly mean at the day of ictus; (ii) deviation from monthly average with respect to changes in daily measures between the day of ictus and two days before; (iii) evolution of daily measures from 5 days before to 5 days after the ICH occurred...
December 10, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27871507/use-of-gabaergic-sedatives-after-subarachnoid-hemorrhage-is-associated-with-worse-outcome-preliminary-findings
#9
Daniel N Hertle, Christopher Beynon, Jan O Neumann, Edgar Santos, Renan Sánchez-Porras, Andreas W Unterberg, Oliver W Sakowitz
STUDY OBJECTIVE: Recent experimental evidence identified GABAergic sedation as a possible cause for deprived neuroregeneration and poor outcome after acute brain injury. Patients with aneurysmal subarachnoid hemorrhage are often sedated, and GABAergic sedation, such as midazolam and propofol, is commonly used. DESIGN: Retrospective cohort study based on a prospectively established database. SETTING: Single-center neurointensive care unit. PATIENTS: Twenty-nine patients after subarachnoid hemorrhage...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27871451/aneurysm-rebleeding-after-poor-grade-aneurysmal-subarachnoid-hemorrhage-predictors-and-impact-on-clinical-outcomes
#10
Bing Zhao, Yilin Fan, Ye Xiong, Rong Yin, Kuang Zheng, Zequn Li, Xianxi Tan, Hua Yang, Ming Zhong
BACKGROUND: Aneurysm rebleeding is a major cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (aSAH) and more often occurs in patients with poor-grade aSAH. Limited data on predictors of rebleeding in these patients are available. OBJECTIVE: To investigate predictors of aneurysm rebleeding after poor-grade aSAH and the association of rebleeding with clinical outcomes. METHODS: A multicenter poor-grade aneurysm study was a prospective and observational registry of consecutive patients who presented with poor-grade aSAH defined as a World Federation of Neurosurgical Societies (WFNS) grade of IV or V...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27871449/botulinum-toxin-as-early-intervention-for-spasticity-after-stroke-or-non-progressive-brain-lesion-a-meta-analysis
#11
Raymond L Rosales, Fran Efendy, Ericka Sa Teleg, Mary Md Delos Santos, Mary Ce Rosales, Marc Ostrea, Michelle J Tanglao, Arlene R Ng
Spasticity is a functionally limiting disorder that commonly occurs following stroke or severe brain injury, and may lead to disability and pain. In tandem with neurorehabilitation, botulinum toxin type A (BoNT-A) is the recommended first-line treatment for spasticity and, to date, the majority of trials have reported BoNT-A use in patients >6months after ictus. The present meta-analysis aimed to evaluate the effects of early BoNT-A injection for post-stroke spasticity on improvements in hypertonicity, disability, function and associated pain...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27846309/use-of-antihypertensive-drugs-and-ischemic-stroke-severity-is-there-a-role-for-angiotensin-ii
#12
Wen Yea Hwong, Michiel L Bots, Sharmini Selvarajah, Zariah Abdul Aziz, Norsima Nazifah Sidek, Wilko Spiering, L Jaap Kappelle, Ilonca Vaartjes
BACKGROUND: The increase in angiotensin II (Ang II) formation by selected antihypertensive drugs is said to exhibit neuroprotective properties, but this translation into improvement in clinical outcomes has been inconclusive. We undertook a study to investigate the relationship between types of antihypertensive drugs used prior to a stroke event and ischemic stroke severity. We hypothesized that use of antihypertensive drugs that increase Ang II formation (Ang II increasers) would reduce ischemic stroke severity when compared to antihypertensive drugs that suppress Ang II formation (Ang II suppressors)...
2016: PloS One
https://www.readbyqxmd.com/read/27845349/granulocyte-colony-stimulating-factor-g-csf-for-stroke-an-individual-patient-data-meta-analysis
#13
Timothy J England, Nikola Sprigg, Andrey M Alasheev, Andrey A Belkin, Amit Kumar, Kameshwar Prasad, Philip M Bath
Granulocyte colony stimulating factor (G-CSF) may enhance recovery from stroke through neuroprotective mechanisms if administered early, or neurorepair if given later. Several small trials suggest administration is safe but effects on efficacy are unclear. We searched for randomised controlled trials (RCT) assessing G-CSF in patients with hyperacute, acute, subacute or chronic stroke, and asked Investigators to share individual patient data on baseline characteristics, stroke severity and type, end-of-trial modified Rankin Scale (mRS), Barthel Index, haematological parameters, serious adverse events and death...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27834742/results-of-the-ictus-2-trial-intravascular-cooling-in-the-treatment-of-stroke-2
#14
Patrick Lyden, Thomas Hemmen, James Grotta, Karen Rapp, Karin Ernstrom, Teresa Rzesiewicz, Stephanie Parker, Mauricio Concha, Syed Hussain, Sachin Agarwal, Brett Meyer, Julie Jurf, Irfan Altafullah, Rema Raman
BACKGROUND AND PURPOSE: Therapeutic hypothermia is a potent neuroprotectant approved for cerebral protection after neonatal hypoxia-ischemia and cardiac arrest. Therapeutic hypothermia for acute ischemic stroke is safe and feasible in pilot trials. We designed a study protocol to provide safer, faster therapeutic hypothermia in stroke patients. METHODS: Safety procedures and 4°C saline infusions for faster cooling were added to the ICTuS trial (Intravascular Cooling in the Treatment of Stroke) protocol...
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27834594/clinical-course-of-untreated-thalamic-cavernous-malformations-hemorrhage-risk-and-neurological-outcomes
#15
Kai-Bing Tian, Jing-Jie Zheng, Jun-Peng Ma, Shu-Yu Hao, Liang Wang, Li-Wei Zhang, Zhen Wu, Jun-Ting Zhang, Da Li
OBJECTIVE The natural history of cerebral cavernous malformations (CMs) has been widely studied, but the clinical course of untreated thalamic CMs is largely unknown. Hemorrhage of these lesions can be devastating. The authors undertook this study to obtain a prospective hemorrhage rate and provide a better understanding of the prognosis of untreated thalamic CMs. METHODS This longitudinal cohort study included patients with thalamic CMs who were diagnosed between 2000 and 2015. Clinical data were recorded, radiological studies were extensively reviewed, and follow-up evaluations were performed...
November 11, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27818312/loss-of-consciousness-at-onset-of-aneurysmal-subarachnoid-hemorrhage-is-associated-with-functional-outcomes-in-good-grade-patients
#16
Justin Wang, Naif M Alotaibi, Muhammad Ali Akbar, Oliver G S Ayling, George M Ibrahim, R Loch Macdonald
BACKGROUND: Transient loss of consciousness (LOC) is one of the most common presentations of aneurysmal subarachnoid hemorrhage (SAH) and may be an indicator of early brain injury. The aim of the current study was to examine the association of LOC to functional outcomes in patients with good-grade SAH. METHODS: We searched the Subarachnoid Hemorrhage International Trialists Repository for patients that presented with LOC at ictus of SAH. A propensity score analysis was performed on good-grade patients (defined as World Federation of Neurosurgical Societies grades 1-3) to balance selected covariates between those with and without LOC...
November 3, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27811309/baseline-characteristics-of-the-3096-patients-recruited-into-the-triple-antiplatelets-for-reducing-dependency-after-ischemic-stroke-trial
#17
Philip Mw Bath, Jason P Appleton, Maia Beridze, Hanne Christensen, Robert A Dineen, Lelia Duley, Timothy J England, Stan Heptinstall, Marilyn James, Kailash Krishnan, Hugh S Markus, Stuart Pocock, Annemarei Ranta, Thompson G Robinson, Katie Flaherty, Polly Scutt, Graham S Venables, Lisa J Woodhouse, Nikola Sprigg
BACKGROUND: The risk of recurrence following ischemic stroke or transient ischemic attack is highest immediately after the event. Antiplatelet agents are effective in reducing the risk of recurrence and two agents are superior to one in the early phase after ictus. DESIGN: The triple antiplatelets for reducing dependency after ischemic stroke trial was an international multicenter prospective randomized open-label blinded-endpoint trial that assessed the safety and efficacy of short-term intensive antiplatelet therapy with three agents (combined aspirin, clopidogrel and dipyridamole) as compared with guideline treatment in acute ischemic stroke or transient ischemic attack...
November 3, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27807280/blood-biomarkers-associated-with-neurological-deterioration-in-patients-with-acute-penetrating-artery-territory-infarction-a-multicenter-prospective-observational-study
#18
Tomohiro Kawano, Kotaro Miyashita, Mariko Takeuchi, Yoshinari Nagakane, Yasumasa Yamamoto, Kenji Kamiyama, Yasuhiro Manabe, Kenichi Todo, Norifumi Metoki, Yasuhisa Akaiwa, Kazunori Toyoda, Kazuyuki Nagatsuka
BACKGROUND AND PURPOSE: Neurological deterioration in acute penetrating artery territory infarction is unpredictable and associated with unfavorable clinical outcomes. The aim of this prospective study was to clarify the cause of neurological worsening and predict clinical outcomes using blood biomarkers. METHODS: Eight Japanese stroke centers participated. Blood samples were obtained within 24 h (the first sampling) and on day 7 in hospital (the second sampling) in patients with penetrating artery territory infarction, arriving within two days of stroke onset...
November 2, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27768752/use-of-a-diagnostic-score-to-prioritize-computed-tomographic-ct-imaging-for-patients-suspected-of-ischemic-stroke-who-may-benefit-from-thrombolytic-therapy
#19
Wen Yea Hwong, Michiel L Bots, Sharmini Selvarajah, L Jaap Kappelle, Zariah Abdul Aziz, Norsima Nazifah Sidek, Ilonca Vaartjes
BACKGROUND: A shortage of computed tomographic (CT) machines in low and middle income countries often results in delayed CT imaging for patients suspected of a stroke. Yet, time constraint is one of the most important aspects for patients with an ischemic stroke to benefit from thrombolytic therapy. We set out to assess whether application of the Siriraj Stroke Score is able to assist physicians in prioritizing patients with a high probability of having an ischemic stroke for urgent CT imaging...
2016: PloS One
https://www.readbyqxmd.com/read/27758945/uric-acid-therapy-prevents-early-ischemic-stroke-progression-a-tertiary-analysis-of-the-urico-ictus-trial-efficacy-study-of-combined-treatment-with-uric-acid-and-r-tpa-in-acute-ischemic-stroke
#20
Sergio Amaro, Carlos Laredo, Arturo Renú, Laura Llull, Salvatore Rudilosso, Víctor Obach, Xabier Urra, Anna M Planas, Ángel Chamorro
BACKGROUND AND PURPOSE: Identification of neuroprotective therapies in acute ischemic stroke is imperative. We report a predefined analysis of the URICO-ICTUS trial (Efficacy Study of Combined Treatment With Uric Acid and r-tPA in Acute Ischemic Stroke) assessing the efficacy of uric acid (UA) compared with placebo to prevent early ischemic worsening (EIW) and the relevance of collateral circulation. METHODS: URICO-ICTUS was a double-blind, placebo-controlled, phase 2b trial where a total of 411 patients treated with alteplase within 4...
November 2016: Stroke; a Journal of Cerebral Circulation
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