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https://www.readbyqxmd.com/read/29444172/motor-and-psychosocial-impact-of-robot-assisted-gait-training-in-a-real-world-rehabilitation-setting-a-pilot-study
#1
Cira Fundarò, Anna Giardini, Roberto Maestri, Silvia Traversoni, Michelangelo Bartolo, Roberto Casale
In the last decade robotic devices have been applied in rehabilitation to overcome walking disability in neurologic diseases with promising results. Robot assisted gait training (RAGT) using the Lokomat seems not only to improve gait parameters but also the perception of well-being. Data on the psychosocial patient-robot impact are limited, in particular in the real-world of RAGT, in the rehabilitation setting. During rehabilitation training, the Lokomat can be considered an "assistive device for movement"...
2018: PloS One
https://www.readbyqxmd.com/read/29428269/comparison-of-craniotomy-and-decompressive-craniectomy-in-large-supratentorial-intracerebral-hemorrhage
#2
Dong Bin Kim, Sang Kyu Park, Byeong Hoo Moon, Byeong Rae Cho, Dong Kyu Jang, Kyeong Sool Jang
Intracerebral hemorrhage (ICH) is devastating disease with high mortality and morbidity rates. Most ICH is evacuated by either craniotomy (CR) or decompressive craniectomy (DC) although optimal treatment has not been established yet. The objective of this study was to compare clinical outcomes of spontaneous ICH patients between CR and DC groups and determine clinical factors affecting clinical prognosis. We retrospectively analyzed our single-center experience with large supratentorial ICH. From January 2011 to December 2016, 286 consecutive supratentorial large ICH patients underwent surgery in our institute...
February 7, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29412162/diagnostic-performance-of-different-perfusion-algorithms-for-the-detection-of-angiographical-spasm
#3
Saif Afat, Carolin Brockmann, Omid Nikoubashman, Marguerite Muller, Kolja M Thierfelder, Wolfgang G Kunz, Ulrike Haberland, Marc A Brockmann, Konstantin Nikolaou, Martin Wiesmann, Ahmed E Othman
PURPOSE: To assess the diagnostic utility of different perfusion algorithms for the detection of angiographical arterial spasm. METHOD: During a 2-year period, 45 datasets from 29 patients (54.2±10,75y,20F) with suspected cerebral vasospasm after aneurysmal subarachnoid hemorrhage were included. Volume Perfusion CT (VPCT), Non-enhanced CT (NCT) and angiography were performed within 6hours post-ictus. Perfusion maps were generated using a maximum slope (MS) and a deconvolution-based approach (DC)...
February 2, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29410100/association-between-neurological-outcomes-related-to-aneurysmal-subarachnoid-haemorrhage-and-onsite-access-to-neurointerventional-radiology
#4
Jorge Pena Mogollon, Nicolas Roydon Smoll, Rakshit Panwar
OBJECTIVE: An onsite access to neurointerventional radiology (NIR) may be useful for managing patients with aneurysmal subarachnoid haemorrhage (aSAH) after the aneurysm-securing procedure. We aimed to assess the association between neurological outcomes related to aSAH and onsite access to NIR service. METHODS: This was a sequential period study of 47 patients with aSAH admitted consecutively during the pre-NIR period (Jan 2010 to Jun 2012) compared with 81 patients with aSAH admitted consecutively during the post-NIR period (Jan 2013 to Jun 2015) at an academic tertiary referral ICU...
February 1, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29409775/atmospheric-pressure-variation-is-a-delayed-trigger-for-aneurysmal-subarachnoid-hemorrhage
#5
Carlina E van Donkelaar, Adriaan R E Potgieser, Henk Groen, Mahrouz Foumani, Herrer Abdulrahman, Rob Sluijter, J Marc C van Dijk, Rob J M Groen
OBJECTIVE: There is an ongoing search for conditions that induce spontaneous subarachnoid hemorrhage (SAH). The seasonal pattern of SAH is demonstrated in a large meta-analysis of the literature, but its explanation remains undecided. As such, there is a clear need for sound meteorological data to further elucidate the seasonal influence on SAH. Because of the stable and densely monitored atmospheric situation in the North of the Netherlands, we reviewed our unique cohort on the seasonal incidence of SAH and the association between SAH and local atmospheric changes...
February 1, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29380719/impact-of-diabetes-on-caregiver-stress-in-patients-with-alzheimer-s-disease-data-from-the-ictus-study
#6
Jun Li, Matteo Cesari, Natalia Del Campo, Sandrine Andrieu, Birong Dong, Wee Shiong Lim, Bruno Vellas
BACKGROUND: To estimate the impact of comorbid diabetes on caregiver stress in Alzheimer's disease (AD) patients from the Impact of Cholinergic Treatment Use (ICTUS) study. METHODS: Using the Data from the ICTUS study, diabetes mellitus (DM) was recorded at baseline and caregiver burden was assessed twice per year using the Zarit Burden Interview (ZBI) scale. The three-factorial model of ZBI (the effect on the social and personal life of caregivers, the psychological burden and the feelings of guilt) was adopted...
January 30, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29354887/delayed-recanalization-promotes-functional-recovery-in-rats-following-permanent-middle-cerebral-artery-occlusion
#7
Devin William McBride, Guangyong Wu, Derek Nowrangi, Jerry J Flores, Liang Hui, Paul R Krafft, John H Zhang
Most large vessel stroke patients have permanent occlusion, for which there are no current treatment options. Recent case studies have indicated delayed recanalization, that is recanalization outside of the 6-h treatment window, may lead to improved outcome. We hypothesized that delayed recanalization will restore cerebral blood flow, leading to improved function in rats. Male SD rats were subjected to pMCAO or sham surgery. Delayed recanalization was performed on either day 3, 7, or 14 after pMCAO in a subset of animals...
January 21, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29354235/compare-the-intracranial-pressure-trend-after-the-decompressive-craniectomy-between-massive-intracerebral-hemorrhagic-and-major-ischemic-stroke-patients
#8
Joon Huh, Seo-Yeon Yang, Han-Yong Huh, Jae-Kun Ahn, Kwang-Wook Cho, Young-Woo Kim, Sung-Lim Kim, Jong-Tae Kim, Do-Sung Yoo, Hae-Kwan Park, Cheol Ji
Objective: Massive intracerebral hemorrhage (ICH) and major infarction (MI) are devastating cerebral vascular diseases. Decompression craniectomy (DC) is a common treatment approach for these diseases and acceptable clinical results have been reported. Author experienced the postoperative intracranaial pressure (ICP) trend is somewhat different between the ICH and MI patients. In this study, we compare the ICP trend following DC and evaluate the clinical significance. Methods: One hundred forty-three patients who underwent DC following massive ICH (81 cases) or MI (62 cases) were analyzed retrospectively...
January 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29276014/early-selective-serotonin-reuptake-inhibitors-for-recovery-after-stroke-a-meta-analysis-and-trial-sequential-analysis
#9
Si-Chun Gu, Chang-De Wang
BACKGROUND: Potential benefits and risks of early (≤30 days from stroke onset) selective serotonin reuptake inhibitors (SSRIs) treatment for neurologic functional recovery after stroke are not fully understood. METHODS: We searched PubMed, Embase, and the Cochrane Library to identify randomized controlled trials that assessed SSRI medications during the initial ictus after stroke versus placebo. Primary outcome was decrease in National Institutes of Health Stroke Scale (NIHSS) score...
December 21, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29235618/-direct-current-electrical-stimulation-in-the-treatment-of-aphasia
#10
REVIEW
I R Montenegro, J A Alvarez-Montesinos, A J Estudillo, J Garcia-Orza
INTRODUCTION: Ictus is a medical condition with a high prevalence in Spanish population. One of its most common consequences is aphasia. Nowadays, aphasia is treated with both neuropsychological and pharmacological therapy. However, in recent years, transcranial direct current stimulation has been presented as a complement to classical therapies. AIMS: To familiarize the reader with transcranial direct current stimulation and to critically review the evidence on the benefits of this technique in aphasia rehabilitation...
December 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/29204018/role-of-biomarkers-in-differentiating-new-onset-seizures-from-psychogenic-nonepileptic-seizures
#11
Mahendra Javali, Purushottam Acharya, Shripal Shah, Rohan Mahale, Pushparaja Shetty, Srinivasa Rangasetty
Introduction: Review of literature revealed very limited studies considering a combination of serum prolactin (PRL) and serum creatine kinase (CK) as markers for differentiating epileptic and psychogenic nonepileptic seizures (PNES). Therefore, in the present study, we analyzed the role of serum PRL and serum CK, individually and in combination. Methodology: This prospective study was conducted in a tertiary care medical teaching hospital over a period of 18 months...
October 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29177494/domain-general-subregions-of-the-medial-prefrontal-cortex-contribute-to-recovery-of-language-after-stroke
#12
Fatemeh Geranmayeh, Tsz Wing Chau, Richard J S Wise, Robert Leech, Adam Hampshire
We hypothesized that the recovery of speech production after left hemisphere stroke not only depends on the integrity of language-specialized brain systems, but also on 'domain-general' brain systems that have much broader functional roles. The presupplementary motor area/dorsal anterior cingulate forms part of the cingular-opercular network, which has a broad role in cognition and learning. Consequently, we have previously suggested that variability in the recovery of speech production after aphasic stroke may relate in part to differences in patients' abilities to engage this domain-general brain region...
July 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29157018/progressive-dna-and-rna-damage-from-oxidation-after-aneurysmal-subarachnoid-hemorrhage-in-humans
#13
A Jorgensen, J M Staalsoe, A H Simonsen, S G Hasselbalch, P Høgh, A Weimann, Poulsen He, N V Olsen
Free radical toxicity is considered a key mechanism in the neuronal damage occurring after aneurysmal subarachnoid hemorrhage (SAH). We measured markers of DNA and RNA damage from oxidation in cerebrospinal fluid from 45 patients with SAH on day 1-14 after ictus and 45 age-matched healthy control subjects. At baseline, both markers were significantly increased in patients compared to controls (p-values < 0.001), and exhibited a progressive further increase (to > 20-fold above control levels) from day 5-14...
November 20, 2017: Free Radical Research
https://www.readbyqxmd.com/read/29119370/vasoconstriction-and-impairment-of-neurovascular-coupling-after-subarachnoid-hemorrhage-a-descriptive-analysis-of-retinal-changes
#14
Catharina Conzen, Walid Albanna, Miriam Weiss, David Kürten, Walthard Vilser, Konstantin Kotliar, Charlotte Zäske, Hans Clusmann, Gerrit Alexander Schubert
Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5-14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C)...
November 8, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29107638/herniation-despite-decompressive-hemicraniectomy-in-large-hemispherical-ischemic-strokes
#15
Archana Hinduja, Rohan Samant, Dongxia Feng, Yousef Hannawi
BACKGROUND: Despite decompressive hemicraniectomy (DHC), progressive herniation resulting in death has been reported following middle cerebral artery (MCA) strokes. We aimed to determine the surgical parameters measured on brain computed tomography (CT) scan that are associated with progressive herniation despite DHC in large MCA strokes. METHODS: Retrospective chart review of medical records of patients with malignant hemispheric infarction who underwent DHC for cerebral edema was performed...
October 26, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29101862/elevated-glycated-hemoglobin-level-and-hyperglycemia-after-aneurysmal-subarachnoid-hemorrhage
#16
Kerim Beseoglu, Hans-Jakob Steiger
OBJECTIVES: Elevated blood glucose is frequently detected early after aneurysmal subarachnoid hemorrhage (aSAH) and is considered a risk factor for poor neurological outcome. However it remains unclear whether hyperglycemia is caused by the SAH ictus or reflects a pre-existing hyperglycemic metabolism. In a prospective register we analysed glycated haemoglobin levels (HbA1c) in patients with aSAH and its influence on outcome. PATIENTS AND METHODS: Between July 2012 and July 2014, 87 patients with confirmed aSAH were included (NCT02081820)...
December 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29096165/mri-supersedes-ictal-eeg-when-other-presurgical-data-are-concordant
#17
Yun Jung Hur, Andrew J Kim, Douglas R Nordli
PURPOSE: When ictal EEG is discordant with MRI and other presurgical data, our group has sometimes discounted the ictal findings and proceeded with epilepsy surgical resection based on MRI. We aimed to evaluate the prudence of such practice by comparing the outcome of MRI-lesional epilepsy surgery patients with discordant ictal EEG with those with concordant ictal EEG. METHOD: We retrospectively studied 115 children with epilepsy who underwent surgical resection of an MRI lesion that was corroborated as the epileptogenic focus by other presurgical findings...
December 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29061461/a-propensity-score-analysis-of-the-impact-of-dexamethasone-use-on-delayed-cerebral-ischemia-and-poor-functional-outcomes-after-subarachnoid-hemorrhage
#18
Nathaniel Mohney, Craig A Williamson, Edward Rothman, Ron Ball, Kyle M Sheehan, Aditya S Pandey, Jeffrey J Fletcher, Teresa L Jacobs, B Gregory Thompson, Venkatakrishna Rajajee
OBJECTIVE: An inflammatory response occurs after aneurysmal subarachnoid hemorrhage (aSAH) and predicts poor outcomes. Glucocorticoids suppress inflammation and promote fluid retention. Dexamethasone is often administered after aSAH for postoperative cerebral edema and refractory headache. Our objective was to examine the impact of dexamethasone use on functional outcomes and delayed cerebral ischemia (DCI) after aSAH. METHODS: Patients with aSAH admitted between 2010 and 2015 were included; the data source was a single-center subarachnoid hemorrhage registry...
January 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29054774/prognostic-significance-of-ultraearly-hematoma-growth-in-spontaneous-intracerebral-hemorrhage-patients-receiving-hematoma-evacuation
#19
Zhiyuan Yu, Jun Zheng, Rui Guo, Lu Ma, Mou Li, Xiaoze Wang, Sen Lin, Chao You, Hao Li
OBJECTIVE: To investigate the association between ultraearly hematoma growth (uHG) and clinical outcome in patients with spontaneous intracerebral hemorrhage (sICH) receiving hematoma evacuation. METHODS: Supratentorial sICH patients receiving hematoma evacuation within 24 hours after ictus were enrolled in this study. uHG was defined as baseline hematoma volume/onset-to-computed tomography (CT) time (ml/h). The outcome was assessed using modified Rankin Scale (mRS) score at 3 months...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29027862/effect-of-body-mass-index-on-outcome-after-aneurysmal-subarachnoid-hemorrhage-treated-with-clipping-versus-coiling
#20
Lorenzo Rinaldo, Joshua D Hughes, Alejandro A Rabinstein, Giuseppe Lanzino
OBJECTIVE It has been suggested that increased body mass index (BMI) may confer a protective effect on patients who suffer from aneurysmal subarachnoid hemorrhage (aSAH). Whether the modality of aneurysm occlusion influences the effect of BMI on patient outcomes is not well understood. The authors aimed to compare the effect of BMI on outcomes for patients with aSAH treated with surgical clipping versus endovascular coiling. METHODS The authors retrospectively reviewed the outcomes for patients admitted to their institution for the management of aSAH treated with either clipping or coiling...
October 13, 2017: Journal of Neurosurgery
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