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oligozoospermia

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https://www.readbyqxmd.com/read/29082206/the-society-for-translational-medicine-clinical-practice-guidelines-for-sperm-dna-fragmentation-testing-in-male-infertility
#1
REVIEW
Ashok Agarwal, Chak-Lam Cho, Ahmad Majzoub, Sandro C Esteves
Sperm DNA fragmentation (SDF) testing has been emerging as a valuable tool for male fertility evaluation. While the essential role of sperm DNA integrity in human reproduction was extensively studied, the clinical indication of SDF testing is less clear. This clinical practice guideline provides recommendations of clinical utility of the test supported by evidence. It is intended to serve as a reference for fertility specialists in identifying the circumstances in which SDF testing should be of greatest clinical value...
September 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29064078/defective-wnt3-expression-by-testicular-sertoli-cells-compromise-male-fertility
#2
Sayon Basu, Satya Pal Arya, Abul Usmani, Bhola Shankar Pradhan, Rajesh Kumar Sarkar, Nirmalya Ganguli, Mansi Shukla, Kamal Mandal, Surendra Singh, Kanchan Sarda, Subeer S Majumdar
Testicular Sertoli cells make a niche for the division and differentiation of germ cells. Sertoli cells respond to increased follicle-stimulating hormone (FSH) and testosterone (T) levels at the onset of puberty by producing paracrine factors which affect germ cells and trigger robust onset of spermatogenesis. Such paracrine support to germ cells is absent during infancy, despite Sertoli cells being exposed to high FSH and T within the infant testis. This situation is similar to certain cases of male idiopathic infertility where post-pubertal Sertoli cells fail to support germ cell division and differentiation in spite of endogenous or exogenous hormonal support...
October 24, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29063501/the-normality-of-sperm-in-an-infertile-man-with-ring-chromosome-15-a-case-report
#3
Kazuyo Nishikawa, Fumiaki Itoi, Miki Nagahara, Mami Jose, Ayumi Matsunaga, Jun Ueda, Takashi Iwamoto
PURPOSE: The purpose of this report is to analyze the chromosome status and fertilization capability of sperm obtained from an infertile male patient with ring chromosome 15. METHODS: This was a case report at a private in vitro fertilization clinic. A man diagnosed with severe oligozoospermia carrying ring chromosome 15. To evaluate the chromosome status and fertilization capability, sperm from a patient carrying ring chromosome 15 were injected into enucleated mouse oocytes...
October 23, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29062795/y-chromosome-microdeletions-in-infertile-men-with-non-obstructive-azoospermia-and-severe-oligozoospermia
#4
Shin Young Kim, Hyun Jin Kim, Bom Yi Lee, So Yeon Park, Hyo Serk Lee, Ju Tae Seo
BACKGROUND: The purpose of the study was to investigate the frequencies and types of Y chromosome microdeletions in infertile men and to analyze the relationship between the levels of reproductive hormones and Y microdeletions. METHODS: A total of 1,226 infertile men were screened for Y chromosome microdeletions using multiplex PCR assay. Karyotype analysis was performed on peripheral blood lymphocytes with standard G-banding. Serum reproductive hormone levels were measured...
July 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/29017965/a-novel-mutation-in-haus7-results-in-severe-oligozoospermia-in-two-brothers
#5
Lin Li, Yan-Wei Sha, Zhi-Ying Su, Li-Bin Mei, Zhi-Yong Ji, Qing Zhang, Shao-Bin Lin, Xu Wang, Ping-Ping Qiu, Ping Li, Chenghong Yin
Severe oligozoospermia (SO) is a common disease resulting in male infertility; however, its pathophysiology remains unclear. Here, we report two brothers with SO. Whole-exome sequencing (WES) identified a hemizygous variant in HAUS7 (c.G386T:p.G129V), an X-linked gene. HAUS7 has been reported to play a role in the meiotic maturation and chromosome alignment of germ cells. The two patients inherited this variant from their mother, and this variant was considered to be a highly pathogenic mutation by in silico analysis...
October 7, 2017: Gene
https://www.readbyqxmd.com/read/28983945/association-between-promoter-methylation-of-mlh1-and-msh2-and-reactive-oxygen-species-in-oligozoospermic-men-a-pilot-study
#6
S Gunes, A Agarwal, R Henkel, A M Mahmutoglu, R Sharma, S C Esteves, A Aljowair, D Emirzeoglu, A Alkhani, L Pelegrini, A Joumah, E Sabanegh
MLH1 and MSH2 are important genes for DNA mismatch repair and crossing over during meiosis and are implicated in male infertility. Therefore, the methylation patterns of the DNA mismatch repair genes MLH1 and MSH2 in oligozoospermic males were investigated. Ten oligozoospermic patients and 29 normozoospermic donors were analysed. Methylation profiles of the MLH1 and MSH2 promotors were analysed. In addition, sperm motility and seminal reactive oxygen species (ROS) were recorded. Receiver operating characteristic (ROC) analysis was conducted to determine the accuracy of the DNA methylation status of MLH1 and MSH2 to distinguish between oligozoospermic and normozoospermic men...
October 6, 2017: Andrologia
https://www.readbyqxmd.com/read/28975488/association-of-tusc1-and-dpf3-gene-polymorphisms-with-male-infertility
#7
Youichi Sato, Chise Hasegawa, Atsushi Tajima, Shiari Nozawa, Miki Yoshiike, Eitetsue Koh, Jiro Kanaya, Mikio Namiki, Kiyomi Matsumiya, Akira Tsujimura, Kiyoshi Komatsu, Naoki Itoh, Jiro Eguchi, Aiko Yamauchi, Teruaki Iwamoto
PURPOSE: Recently, genome-wide association studies of a Hutterite population in the USA revealed that five single nucleotide polymorphisms (SNPs) with a significant association with sperm quality and/or function in ethnically diverse men from Chicago were significantly correlated with family size. Of these, three SNPs (rs7867029, rs7174015, and rs12870438) were found to be significantly associated with the risk of azoospermia and/or oligozoospermia in a Japanese population. In this study, we investigated whether the rs10966811 (located in an intergenic region between the TUSC1 and IZUMO3 genes) and rs10129954 (located in the DPF3 gene) SNPs, previously related to family size, are associated with male infertility...
October 3, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28974117/association-of-c3953t-transition-in-interleukin-1%C3%AE-gene-with-idiopathic-male-infertility-in-an-iranian-population
#8
Tayyebeh Zamani-Badi, Mohammad Karimian, Abolfazl Azami-Tameh, Hossein Nikzad
In this study we investigate the association of C3953T transition single nucleotide polymorphism in the fifth exon of the interleukin 1β gene with idiopathic male infertility. In a case-control study, blood samples were collected from 230 fertile and 207 infertile men who referred to the Kashan IVF centre. Genotypes of samples at the C3953T location were determined by polymerase chain reaction-restriction fragment length polymorphism. The data showed a significant association of TT genotype (OR = 2.49, 95%CI = 1...
October 3, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28969154/gene-scanning-for-microdeletions-in-the-azoospermia-factor-region-of-y-chromosome-in-infertile-men-of-gujarat-india
#9
Mili Nailwal, Jenabhai B Chauhan
INTRODUCTION: Azoospermia Factor (AZF) microdeletions in Yq chromosome is one of the most frequent genetic cause associated with failure of spermatogenesis in males with infertility. AIM: To figure out the Yq chromosome microdeletions frequency in infertile men from Gujarat region of India. MATERIALS AND METHODS: In this study, 141 infertile men with azoospermia (n=41) and oligozoospermia (n=100) were examined along with 159 normozoospermic men...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28967062/male-infertility-rate-a-retrospective-study
#10
Bihari L Mehra, Kalanghot P Skandhan, Buduru S Prasad, Godatwar Pawankumar, Gurdip Singh, Vasudevan Jaya
INTRODUCTION: Worldwide, male responsible infertility is on the rise. In this retrospective study, we evaluated the infertility rate of this area. MATERIALS AND METHODS: Cases reported from 1989 to 1993 to the Institute for Post Graduate Teaching and Research in Ayurved University were studied. Semen reports were also scrutinized. RESULTS: A total number of 1,17,979 cases were examined. Male infertility rate was 45%. Patients' semen report showed that they were with oligozoospermia (22%), asthenozoospermia (11%) and azoospermia (12%)...
September 22, 2017: Urologia
https://www.readbyqxmd.com/read/28961722/how-effective-are-weight-loss-interventions-for-improving-fertility-in-women-and-men-who-are-overweight-or-obese-a-systematic-review-and-meta-analysis-of-the-evidence
#11
Damian Best, Alison Avenell, Siladitya Bhattacharya
BACKGROUND: The prevalence of obesity is increasing worldwide, with a corresponding increase in overweight and obese patients referred with infertility. This systematic review aimed to determine whether non-surgical weight reduction strategies result in an improvement in reproductive parameters affected by obesity, e.g. delayed time to pregnancy, oligozoospermia and azoospermia. No prior reviews have examined this within the general fertility population, or in both sexes. OBJECTIVE AND RATIONALE: Our objective was to answer the question: 'In overweight and obese women, men and couples seeking fertility treatment, what non-surgical weight-loss interventions have been used, and how effective are they at weight loss and improving reproductive outcomes?' SEARCH METHODS: An electronic search of MEDLINE, EMBASE and the Cochrane Library was performed for studies between January 1966 and March 2016...
November 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28934280/recurrent-deletions-of-the-x-chromosome-linked-cnv64-cnv67-and-cnv69-shows-geographic-differences-across-china-and-no-association-with-idiopathic-infertility-in-men
#12
Xiulan Ma, Martin Kuete, Xiuli Gu, Hui Zhou, Chengliang Xiong, Honggang Li
A recent study found that three recurrent deletions of X chromosome linked copy number variations (CNVs), CNV64, CNV67 and CNV69 were associated with idiopathic male infertility in Spanish and Italian populations, especially CNV67 resembling the azoospermia factor deletions. That merits further investigations among different populations. This study was conducted to examine the prevalence of the three CNVs deletions and their associations with idiopathic male infertility in Chinese Han population. The present study included a large population of 1550 Chinese Han subjects recruited between 2014 and 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28888863/increased-insulin-resistance-in-men-with-unexplained-infertility
#13
Ragaa Mansour, Yahia El-Faissal, Ahmed Kamel, Omnia Kamal, Gamal Aboulserour, Mohamed Aboulghar, Ibrahim Fahmy
This prospective case-control study aimed to test the presence of insulin resistance (IR) in men with unexplained infertility. We included two groups: the study group including 160 infertile men with unexplained oligozoospermia (sperm count <10 × 10(6)/ml) and normal hormonal profile, and the control group of 79 men with proven fertility within the preceding year. A fasting blood test measured IR, FSH, LH, total cholesterol, low-density lipoprotein, high-density lipoprotein and triglycerides. Insulin level was significantly higher in the study group (13...
August 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28801929/validation-and-application-of-a-novel-integrated-genetic-screening-method-to-a-cohort-of-1-112-men-with-idiopathic-azoospermia-or-severe-oligozoospermia
#14
Manon S Oud, Liliana Ramos, Moira K O'Bryan, Robert I McLachlan, Özlem Okutman, Stephane Viville, Petra F de Vries, Dominique F C M Smeets, Dorien Lugtenberg, Jayne Y Hehir-Kwa, Christian Gilissen, Maartje van de Vorst, Lisenka E L M Vissers, Alexander Hoischen, Aukje M Meijerink, Kathrin Fleischer, Joris A Veltman, Michiel J Noordam
Microdeletions of the Y chromosome (YCMs), Klinefelter syndrome (47,XXY), and CFTR mutations are known genetic causes of severe male infertility, but the majority of cases remain idiopathic. Here, we describe a novel method using single molecule Molecular Inversion Probes (smMIPs), to screen infertile men for mutations and copy number variations affecting known disease genes. We designed a set of 4,525 smMIPs targeting the coding regions of causal (n = 6) and candidate (n = 101) male infertility genes. After extensive validation, we screened 1,112 idiopathic infertile men with non-obstructive azoospermia or severe oligozoospermia...
November 2017: Human Mutation
https://www.readbyqxmd.com/read/28764642/the-susceptibility-of-fshb-211g%C3%A2-%C3%A2-t-and-fshr-g-29a-919a%C3%A2-%C3%A2-g-2039a%C3%A2-%C3%A2-g-polymorphisms-to-men-infertility-an-association-study-and-meta-analysis
#15
Qiuyue Wu, Jing Zhang, Peiran Zhu, Weijun Jiang, Shuaimei Liu, Mengxia Ni, Mingchao Zhang, Weiwei Li, Qing Zhou, Yingxia Cui, Xinyi Xia
BACKGROUND: Male infertility is a complex disorder caused by genetic, developmental, endocrine, or environmental factors as well as unknown etiology. Polymorphisms in the follicle stimulating hormone beta subunit (FSHB) (rs10835638, c.-211G > T) and follicle stimulating hormone receptor (FSHR) (rs1394205, c.-29G > A; rs6165, c.919A > G; rs6166, c.2039 A > G) genes might disturb normal spermatogenesis and affect male reproductive ability. METHODS: To further ascertain the aforementioned effects, we conducted a case-control study of 255 infertile men and 340 fertile controls from South China using the Mass ARRAY method, which was analyzed by the t-tests and logistic regression analysis using SPSS for Windows 14...
August 1, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28762516/fluorescence-in-situ-hybridisation-sperm-examination-is-significantly-impaired-in-all-categories-of-male-infertility
#16
S Petousis, Y Prapas, A Papatheodorou, C Margioula-Siarkou, G Papatzikas, Y Panagiotidis, A Karkanaki, K Ravanos, N Prapas
To study the outcome of FISH sperm examination in cases with sperm pathology and outline the potential correlation with certain chromosomal defects. A retrospective study of prospectively collected data was performed in IAKENTRO, Infertility Treatment Center. Rates of abnormal FISH semen examination were compared between male infertility patients and fertile controls. Detection of abnormal FISH semen examination as well as each chromosomal abnormality detected was correlated with each sperm deficiency (asthenozoospermia, oligozoospermia and teratozoospermia) in a univariate regression model...
August 1, 2017: Andrologia
https://www.readbyqxmd.com/read/28746727/idiopathic-male-infertility-related-to-periodontal-and-caries-status
#17
Nándor Práger, Norbert Pásztor, Ákos Várnagy, Zoltan Kozinszky, Zoltán Baráth, István Gorzó, Márta Radnai
OBJECTIVES: This study was undertaken to evaluate the possible correlation between the periodontal and dental status and sperm pathology in idiopathic male infertility. METHODS: The periodontal and caries status and semen quality of 199 men presented with unexplained male infertility were examined. Periodontal and dental factors were analysed by sperm pathology categories. RESULTS: A total of 106 men had normal sperm parameters, whereas 93 men had some type of spermpathology; 27...
July 26, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28730893/multicenter-study-of-genetic-abnormalities-associated-with-severe-oligospermia-and-non-obstructive-azoospermia
#18
Chong Xie, Xiangfeng Chen, Yulin Liu, Zhengmu Wu, Ping Ping
Objective * Chong Xie, Xiangfeng Chen, and Yulin Liu contributed equally to this work. Genetic defects are identified in nearly 20% of infertile males. Determining the frequency and types of major genetic abnormalities in severe male infertility helps inform appropriate genetic counseling before assisted reproductive techniques. Methods Cytogenetic results of 912 patients with non-obstructive azoospermia (NOA) and severe oligozoospermia (SOS) in Eastern China were reviewed in this multicenter study from January 2011 to December 2015...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28718894/sperm-cryopreservation-and-assisted-reproductive-technology-outcome-in-patients-with-spinal-cord-injury
#19
A Reignier, J Lammers, C Splingart, D Redhead, J J Labat, S Mirallié, P Barrière, T Fréour
This study aimed to describe spinal cord injured patients' semen characteristics before and after cryopreservation, and assisted reproductive technology cycles outcome compared to the infertile population. Data about sperm analysis and assisted reproductive technology (ART) cycles outcomes for 78 men with spinal cord injury referred for sperm cryopreservation between 1998 and 2013 were retrospectively analysed and compared with a reference group consisting of every Intra Cytoplasmic Sperm Injection (ICSI) cycle performed in our in vitro fertilization unit over the 2009-2014 period...
July 18, 2017: Andrologia
https://www.readbyqxmd.com/read/28670432/relationship-between-chlamydia-ureaplasma-mycoplasma-genital-detection-with-semen-concentration-and-motility-among-greek-men
#20
Ageliki Gerovassili, Ourania Marcandona, Byron Asimakopoulos, Vasilis Karavasilis, Maria Panopoulou, Alexandros Ikonomidis
One hundred and seventy two men at the State of Thessaly, Greece, inquiring semen analysis were enrolled in the study in order to investigate the incidence of Chlamydia, Ureaplasma and Mycoplasma (C-U-M) genera in respect to total sperm number (TSN), progressive motility (grades a and b) and total motility (grades a, b and c). Putative relation of C-U-M acquirement with sexual behavior was also investigated. Incidence of C-U-M among non-oligozoospermic and oligozoospermic men was similar. Νο correlation of C-U-M carriage to either oligozoospermia or asthenozoospermia was found...
July 2017: International Journal of Fertility & Sterility
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