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https://www.readbyqxmd.com/read/28077670/the-mammalian-efferent-vestibular-system-plays-a-crucial-role-in-vestibulo-ocular-reflex-compensation-after-unilateral-labyrinthectomy
#1
Patrick P Hübner, Serajul I Khan, Americo A Migliaccio
The α9 nicotinic acetylcholine receptor (α9-nAChR) subunit is expressed in the vestibular and auditory periphery, and its loss of function could compromise peripheral input from the predominantly-cholinergic efferent vestibular system (EVS). A recent study has shown that α9-nAChRs play an important role in short-term vestibulo-ocular reflex (VOR) adaptation. We hypothesise that α9-nAChRs could also be important for other forms of vestibular plasticity, such as that needed for VOR recovery after vestibular organ injury...
January 11, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28077250/role-of-video-head-impulse-test-in-lateralization-of-vestibulopathy-comparative-study-with-caloric-test
#2
Pona Park, Joo Hyun Park, Ji Soo Kim, Ja-Won Koo
OBJECTIVE: To evaluate the lateralization value of video head-impulse test (vHIT) for the diagnosis of vestibulopathy and to analyze cases showing dissociated results with caloric test. METHODS: In total, 19 healthy volunteers and 92 dizzy patients who underwent both a caloric test and a vHIT were enrolled. Patients were divided into two groups depending on their fluctuating pattern of vertigo. The vestibulo-ocular reflex (VOR) gain and gain asymmetry (GA) of a vHIT as well as unilateral weakness (UW) and the sum of the slow-phase velocities (SPVs) of warm and cold irrigation of the same side were compared...
January 8, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28063365/aging-reduces-the-high-frequency-and-short-term-adaptation-of-the-vestibulo-ocular-reflex-in-mice
#3
Serajul I Khan, Patrick P Hübner, Alan M Brichta, Doug W Smith, Americo A Migliaccio
Prevailing evidence indicates a relatively late life decline in human vestibulo-ocular reflex (VOR) function. Although mice are commonly used in mechanistic studies of vestibular function, it remains unclear whether aging produces a corresponding decline in VOR function in mice. We sought to determine how the baseline VOR and its short-term adaptation were affected by aging. We tested 8 young (3-month old) and 8 aged (30-month old-equivalent to a ∼80-year old human) C57BL/6 mice. We measured their VOR response to whole-body static tilts and during 0...
December 18, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/28045862/comparing-azole-plasma-trough-levels-in-lung-transplant-recipients-percentage-of-therapeutic-levels-and-intra-patient-variability
#4
Daniela Stelzer, Alexandra Weber, Franziska Ihle, Sandhya Matthes, Felix Ceelen, Gregor Zimmermann, Nikolaus Kneidinger, Rene Schramm, Hauke Winter, Michael Zoller, Michael Vogeser, Juergen Behr, Claus Neurohr
BACKGROUND: This study compared therapeutic azole plasma trough levels (APL) of the azole antimycotics itraconazole (ITR), voriconazole (VOR), and posaconazole (POS) in lung transplant recipients and analyzed the influencing factors. In addition, intra-patient variability for each azole was determined. METHODS: From July 2012 to July 2015, 806 APL of ITR, VOR, POS liquid (POS-Liq), and POS tablets (POS-Tab) were measured in 173 patients of the Munich Lung Transplantation (LTx) Program...
December 29, 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28019659/na-h-exchanger-nhe1-and-nhe2-have-opposite-effects-on-migration-velocity-in-the-rat-gastric-surface-cells
#5
Anja Paehler Vor der Nolte, Giriprakash Chodisetti, Zhenglin Yuan, Florian Busch, Brigitte Riederer, Min Luo, Yan Yu, Manoj B Menon, Andreas Schneider, Renata Stripecke, Katerina Nikolovska, Sunil Yeruva, Ursula Seidler
Following superficial injury, neighbouring gastric epithelial cells close the wound by rapid cell migration, a process called epithelial restitution. Na(+) /H(+) exchange (NHE) inhibitors interfere with restitution, but the role of the different NHE isoforms expressed in gastric pit cells has remained elusive. The role of the basolaterally expressed NHE1 (Slc9a1) and the presumably apically expressed NHE2 (Slc9a2) in epithelial restitution was investigated in the nontransformed rat gastric surface cell line RGM1...
December 26, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28018691/intra-attack-vestibuloocular-reflex-changes-in-m%C3%A3-ni%C3%A3-re-s-disease
#6
Dario A Yacovino, John B Finlay
Ménière's attack has been shown to temporarily alter the vestibuloocular reflex (VOR). A patient with unilateral Ménière's disease was serially evaluated with the video Head Impulse Test during single, untreated episodes of acute vertigo. Spontaneous nystagmus activity was concurrently recorded in order to establish the three typical phases of Ménière's attack (irritative, paralytic, and recovery) and correlate them with VOR performance. The onset of attack was associated with a quick change in VOR gain on the side of the affected ear...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28012675/saccadic-entropy-of-head-impulses-in-acute-unilateral-vestibular-loss
#7
Li-Chun Hsieh, Hung-Ching Lin, Guo-She Lee
BACKGROUND/PURPOSE: To evaluate the complexity of vestibular-ocular reflex (VOR) in patients with acute unilateral vestibular loss (AUVL) via entropy analysis of head impulses. METHODS: Horizontal head impulse test (HIT) with high-velocity alternating directions was used to evaluate 12 participants with AUVL and 16 healthy volunteers. Wireless electro-oculography and electronic gyrometry were used to acquire eye positional signals and head velocity signals. The eye velocity signals were then obtained through differentiation, band-pass filtering...
December 21, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28010157/evaluation-of-immune-response-in-challenged-chickens-vaccinated-with-newcastle-disease-vaccine-using-gums-from-cedrela-odorata-and-khaya-senegalensis-as-delivery-agents
#8
V O Oyebanji, B O Emikpe, Omolade A Oladele, M O Odeniyi, A Salami, O I Osowole, O B Kasali, O A Akinboade
Immune response of challenged chickens following previous vaccinations with Newcastle disease vaccine using gums from Cedrela odorata and Khaya senegalensis as delivery agent were evaluated. Two hundred and fifty-two (252) one-day old chickens were divided into vaccine-gum oral (GVOR), vaccine-gum ocular (GVOC), vaccine oral (VOR), vaccine ocular (VOC), gum oral (GOR), gum ocular (GOC), No-gum-no-vaccine/challenged (NGNV/C) & No-gum-no-vaccine/unchallenged (NGNV/U) groups. They were vaccinated at days 21 & 42 and challenged at day 84...
December 23, 2016: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/27993720/synergistic-anticancer-activity-of-combined-histone-deacetylase-and-proteasomal-inhibitor-loaded-zein-nanoparticles-in-metastatic-prostate-cancers
#9
Raj Kumar Thapa, Hanh Thuy Nguyen, Jee-Heon Jeong, Beom Soo Shin, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
The development of resistance and subsequent metastasis makes prostate cancer a leading cause of cancer-related death among men. Hence, nanoparticle-based combination chemotherapeutics could be a viable treatment strategy. We aimed to prepare vorinostat (Vor) and bortezomib (Bor) combination-loaded zein nanoparticles (ZNP, ZNP/VB) for treating metastatic prostate cancers. Our results revealed the successful preparation of ZNP/VB with a small particle size (~160nm) and polydispersity index (~0.20). Importantly, controlled and pH-dependent drug release profiles were observed...
December 18, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27992138/azelains%C3%A3-ure-20%C3%A2-creme-auswirkung-auf-lebensqualit%C3%A3-t-und-krankheitsaktivit%C3%A3-t-bei-erwachsenen-patientinnen-mit-acne-vulgaris
#10
Julius Thomas Kainz, Gabriele Berghammer, Piet Auer-Grumbach, Verena Lackner, Sylvia Perl-Convalexius, Rodica Popa, Barbara Wolfesberger
HINTERGRUND: Zur Wirksamkeit von Aknetherapien und deren Auswirkungen auf die Lebensqualität erwachsener Patienten liegen kaum Daten vor. ZIEL: Erhebung der Wirkung von Azelainsäure 20 % Creme (Skinoren(®) ) auf Akne-Schweregrad und krankheitsbedingte Lebensqualität. PATIENTEN UND METHODIK: Nichtinterventionelle Studie bei erwachsenen Patientinnen mit leichter bis mittelschwerer Akne. Wirksamkeitsparameter waren DLQI sowie Akne-Schweregrad im Gesicht, am Dekolleté sowie am Rücken im Gesamturteil des Prüfarztes (IGA-Skala: Grad 1 = annähernd reine Haut; 2 = leichte Akne; 3 = mittelschwere Akne)...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27956722/effect-of-goggle-slippage-on-the-video-head-impulse-test-outcome-and-its-mechanisms
#11
Myung-Whan Suh, Jae Hong Park, Seong Il Kang, Jae Hyun Lim, Moo Kyun Park, Seong Keun Kwon
OBJECTIVES: The aim of this study was to quantitatively measure the tightness of the goggle strap during the video head impulse test (vHIT) and to identify slippage-induced artifacts according to tightness. We aimed to elucidate the mechanism of faulty gain caused by goggle slippage and explain the typical artifacts associated with it. SUBJECTS AND METHODS: An endotracheal tube cuff manometer was coupled to the EyeSeeCam vHIT system (Interacoustics, Assens, Denmark) to monitor strap tightness...
January 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/27926585/fluctuating-vestibulo-ocular-reflex-in-m%C3%A3-ni%C3%A3-re-s-disease
#12
Dario A Yacovino, Timothy C Hain, Maria Musazzi
OBJECTIVES: To describe the fluctuating high velocity vestibular ocular-reflex (VOR) during the Ménière's attacks and correlate those features with pathophysiology. PATIENTS: A patient with unilateral Ménière's disease (MD) was evaluated closely during and after acute vertigo episodes. MAIN OUTCOME MEASURES: The spontaneous nystagmus and the dynamic VOR changes were measured by the video head impulse test (VHIT) at different stages of the vertigo crisis and during the quiescent phase of the condition...
December 6, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27898608/effect-of-spatial-orientation-of-the-horizontal-semicircular-canal-on-the-vestibulo-ocular-reflex
#13
Rebecca Maxwell, Constantin von Kirschbaum, Claudia Jerin, Nadine Lehnen, Eike Krause, Robert Gürkov
OBJECTIVE: To determine if an alignment of the horizontal semi-circular canal (hSCC) with the plane of rotation would enhance the vestibular-ocular reflex (VOR) gain result as it has been previously suggested. STUDY DESIGN: Comparative study of a physiological vestibular function test in healthy subjects. SETTING: Tertiary referral center for otology and neurotology. PATIENTS: Twenty two healthy volunteers were recruited for this study...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27893205/patterns-of-recurrence-after-resection-of-mass-forming-type-intrahepatic-cholangiocarcinomas
#14
Vor Luvira, Chalerm Eurboonyanun, Vajarabhongsa Bhudhisawasdi, Ake Pugkhem, Chawalit Pairojkul, Varisara Luvira, Egapong Sathitkarnmanee, Kulyada Somsap, Supot Kamsa-ard
Background: Intrahepatic cholangiocarcinoma (IHCCA) is an aggressive tumor for which surgical resection is a mainstay of treatment. However, recurrence after resection is common associated with a poor prognosis. Studies regarding recurrence of mass-forming IHCCA are rare; therefore, we investigated the pattern with our dataset. Methods: We retrospectively reviewed the medical and pathological records of 50 mass-forming IHCCA patients who underwent hepatic resection between January 2004 and December 2009 in order to determine the patterns of recurrence and prognosis...
1, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27879103/nagelbefall-kann-bei-patienten-mit-psoriasis-auf-eine-enthesiopathie-hinweisen
#15
Maria Castellanos-González, Beatriz Esther Joven, Julio Sánchez, Eva María Andrés-Esteban, Francisco Vanaclocha-Sebastián, Pablo Ortiz Romero, Raquel Rivera Díaz
HINTERGRUND: Obwohl subklinische Enthesiopathie ein gut etabliertes diagnostisches Merkmal der Psoriasisarthritis (PsA) ist, wird sie häufig übersehen, da viele Patienten asymptomatisch sind. Gäbe es klinische Hinweise auf das Vorliegen einer Enthesiopathie, würde dies den Klinikern die Möglichkeit eröffnen, eine PsA frühzeitig zu diagnostizieren. MATERIAL UND METHODEN: Es wurde eine monozentrische prospektive Studie mit insgesamt 90 Psoriasis-Patienten durchgeführt, um mittels Ultraschall das Vorliegen von Enthesenanomalien zu untersuchen und eine Korrelation mit dem Befall der Nägel festzustellen...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27877114/ontogenetic-development-of-vestibulo-ocular-reflexes-in-amphibians
#16
REVIEW
Francisco Branoner, Boris P Chagnaud, Hans Straka
Vestibulo-ocular reflexes (VOR) ensure gaze stability during locomotion and passively induced head/body movements. In precocial vertebrates such as amphibians, vestibular reflexes are required very early at the onset of locomotor activity. While the formation of inner ears and the assembly of sensory-motor pathways is largely completed soon after hatching, angular and translational/tilt VOR display differential functional onsets and mature with different time courses. Otolith-derived eye movements appear immediately after hatching, whereas the appearance and progressive amelioration of semicircular canal-evoked eye movements is delayed and dependent on the acquisition of sufficiently large semicircular canal diameters...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27814315/compensatory-saccades-in-head-impulse-testing-influence-the-dynamic-visual-acuity-of-patients-with-unilateral-peripheral-vestibulopathy1
#17
V G Wettstein, K P Weber, C J Bockisch, S C Hegemann
BACKGROUND: Both the dynamic visual acuity (DVA) test and the video head-impulse test (vHIT) are fast and simple ways to assess peripheral vestibulopathy. After losing peripheral vestibular function, some patients show better DVA performance than others, suggesting good compensatory mechanisms. It seems possible that compensatory covert saccades could be responsible for improved DVA. OBJECTIVE: To investigate VOR gain and compensatory saccades with vHIT and compare them to the DVA of patients with unilateral peripheral vestibulopathy...
November 3, 2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/27814312/impact-of-artifacts-on-vor-gain-measures-by-video-oculography-in-the-acute-vestibular-syndrome
#18
Georgios Mantokoudis, Ali S Saber Tehrani, Amy Wozniak, Karin Eibenberger, Jorge C Kattah, Cynthia I Guede, David S Zee, David E Newman-Toker
OBJECTIVE: The video head impulse test (HIT) measures vestibular function (vestibulo-ocular reflex [VOR] gain - ratio of eye to head movement), and, in principle, could be used to make a distinction between central and peripheral causes of vertigo. However, VOG recordings contain artifacts, so using unfiltered device data might bias the final diagnosis, limiting application in frontline healthcare settings such as the emergency department (ED). We sought to assess whether unfiltered data (containing artifacts) from a video-oculography (VOG) device have an impact on VOR gain measures in acute vestibular syndrome (AVS)...
November 3, 2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/27789472/a-positive-vestibular-ocular-motor-screening-voms-is-associated-with-increased-recovery-time-after-sports-related-concussion-in-youth-and-adolescent-athletes
#19
Anthony J Anzalone, Damond Blueitt, Tami Case, Tiffany McGuffin, Kalyssa Pollard, J Craig Garrison, Margaret T Jones, Robert Pavur, Stephanie Turner, Jonathan M Oliver
BACKGROUND: Vestibular and ocular motor impairments are routinely reported in patients with sports-related concussion (SRC) and may result in delayed return to play (RTP). The Vestibular/Ocular Motor Screening (VOMS) assessment has been shown to be consistent and sensitive in identifying concussion when used as part of a comprehensive examination. To what extent these impairments or symptoms are associated with length of recovery is unknown. PURPOSE: To examine whether symptom provocation or clinical abnormality in specific domains of the VOMS results in protracted recovery (time from SRC to commencement of RTP protocol)...
October 27, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27774659/the-role-of-drug-efflux-pumps-in-malassezia-pachydermatis-and-malassezia-furfur-defence-against-azoles
#20
Roberta Iatta, Maria Rita Puttilli, Davide Immediato, Domenico Otranto, Claudia Cafarchia
This study aims to evaluate the effect of efflux pump modulators (EPMs) on the minimal inhibitory concentration (MIC) of fluconazole (FLZ) and voriconazole (VOR) in Malassezia furfur and Malassezia pachydermatis. The in vitro efficacy of azoles, in combination with EPMs (ie haloperidol-HAL, promethazine-PTZ and cyclosporine A-CYS), against 21 M. furfur from bloodstream infection patients and 14 M. pachydermatis from the skin of dogs with dermatitis, was assessed using a broth microdilution chequerboard analysis...
October 24, 2016: Mycoses
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