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https://www.readbyqxmd.com/read/28545546/emulsifying-dietary-fat-modulates-postprandial-endotoxemia-associated-with-chylomicronemia-in-obese-men-a-pilot-randomized-crossover-study
#1
Cécile Vors, Jocelyne Drai, Gaëlle Pineau, Martine Laville, Hubert Vidal, Fabienne Laugerette, Marie-Caroline Michalski
BACKGROUND: Postprandial hyperlipemia is recognized as a major cardio-metabolic risk factor, recently linked to the co-absorption of pro-inflammatory lipopolysaccharides with dietary lipids. This causes endotoxemia that is involved in the pathophysiology of obesity and insulin resistance, but to date the impact of food formulation is unknown. We tested a novel concept that endotoxin absorption can be modulated by fat emulsified structure in the meal, and potentially differently in obese vs...
May 25, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28515977/establishing-normative-change-values-in-visual-acuity-loss-during-the-dynamic-visual-acuity-test
#2
Chris Marquez, Monica Lininger, Scot Raab
BACKGROUND: Baseline visual acuity (VA) loss from static to dynamic head conditions assessed using the Dynamic Visual Acuity Testing (DVAT) have not been established in NCAA football players. DVAT assesses the Vestibulo-Ocular Reflex (VOR) which is measured in Logarithm of the Minimum Angle of Resolution (logMAR). Decreased VA beyond baseline measures may detect VOR impairment and impact treatment protocols and assist in return to play decisions post-concussion. HYPOTHESIS/PURPOSE: To establish normative VA mean scores during a static head posture as well as dynamically during the DVAT with a head speed of 150 deg/s in the pitch (vertical) and yaw (horizontal) planes rotating 20 degrees in each direction...
April 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28515020/supplementation-with-high-dose-docosahexaenoic-acid-increases-the-omega-3-index-more-than-high-dose-eicosapentaenoic-acid
#3
Janie Allaire, William S Harris, Cécile Vors, Amélie Charest, Johanne Marin, Kristina Harris Jackson, André Tchernof, Patrick Couture, Benoît Lamarche
BACKGROUND: Recent studies suggest that eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids have distinct effects on cardiometabolic risk factors. The Omega-3 Index (O3I), which is calculated as the proportion of EPA and DHA in red blood cell (RBC) membranes, has been inversely associated with the risk of coronary heart diseases and coronary mortality. The objective of this study was to compare the effects of EPA and DHA supplementation on the O3I in men and women with abdominal obesity and subclinical inflammation...
May 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28504830/exploring-planar-chiral-amino-siloxides
#4
Christopher Golz, Patricia Steffen, Carsten Strohmann
Die Synthese, Struktur und exemplarische Reaktivität von Siloxiden mit planarchiralen N,N-Dimethylaminomethylferrocen-Rückgrat wird vorgestellt. Mehrere Zinkkomplexe ausgehend aus dem racemischen als auch dem enantiomerenreinen Silanol wurden in Gegenwart von Wasser synthetisiert, kristallographisch charakterisiert und ihr Verhalten in Lösung untersucht. Die in diesem System vorhandene chirale Sonde stellt sich als wertvolles Werkzeug zur Identifizierung der vorliegenden Struktur in Lösung heraus. Weiterhin zeigen die Zinksiloxide eine vergleichbare Reaktivität wie die korrespondierenden Silanole, daher bieten sich diese als "maskierte" Silanole an, vor allem dann, wenn die Silanole präparativ unzugänglich sind...
May 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28504057/molecular-dynamic-modeling-of-cyp51b-in-complex-with-azole-inhibitors
#5
Pan Gao, Yinglu Cui, Rongling Wu
Cytochrome P450 14α-sterol demethylase (CYP51), the key enzyme in sterol biosynthesis pathway, is an important target protein of cholesterol-lowering agents, antifungal drugs and herbicides. CYP51B enzyme is one of the CYP51 family members. In the present study, we have chosen four representative inhibitors of CYP51B: diniconazole(Din), fluconazole(Flu), tebuconazole(Teb), voriconazole(Vor) and launched to investigate the binding features of CYP51B-inhibitor and gating characteristics via molecular docking and molecular dynamics(MD) simulations...
May 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28486738/-isolated-high-frequency-hvor-lesion-in-patients-with-chronic-dizziness
#6
Roland Hülse, Manfred Hülse, Karl Hörmann, Matthias Hölzl, Richard Birk, Angela Wenzel
In the presented study video-head impulse test (vHIT) was performed in 72 patients with complaints of dizziness for more than 3 months who did not show any pathology in rotatory chair testing or caloric test, in order to analyzed high frequency vestibular-ocular-reflex (VOR). Retrospective data analyzed of rotatory chair testing, caloric tests and vHIT results were accomplished in 72 patients. Gain, gain variance and the occurrence of catch-up saccades were measured. 10 patients (n=10; 13.8%) showed pathologic vHOR results with reduced gain...
May 9, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28486231/decrease-of-horizontal-canal-vestibulo-oculomotor-reflex-gain-in-the-elderly-with-dysequilibrium-without-lifetime-vertigo
#7
Roberto Teggi, Matteo Trimarchi, Omar Gatti, Francesco Fornasari, Mario Bussi
BACKGROUND/AIMS: Unsteadiness in the elderly is a frequent complaint and a strong predictor of falls and psychological distress. Although there is a general consensus that it is a multifactorial condition, recent studies have focused on the role of aging of the vestibular system as a possible cofactor. The aim of our work was to assess horizontal canal function in the elderly. METHODS: We evaluated the gain of horizontal vestibulo-ocular reflex (VOR) with a video head impulse test on a sample of 58 subjects aged >70 years without lifetime episodes of vertigo and correlated the value with different clinical conditions (hypertension, diabetes, prior cardiovascular and vascular disorders of the central nervous system, and falls)...
May 10, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28485873/diagnostische-pr%C3%A3-zision-der-komponentenbasierten-vs-der-extraktbasierten-in-vitro-diagnostik-von-insektengift-allergien-auswirkungen-auf-das-klinische-management
#8
Florian Seyfarth, Diana Miguel, Sibylle Schliemann, Uta-Christina Hipler
HINTERGRUND: Die Bestimmung von spezifischen IgE-Antikörpern spielt eine zentrale Bedeutung bei der Diagnostik von Bienen- und Wespengiftallergien. In den letzten Jahren wurden die komponentenbasierte Diagnostik (CRD) eingeführt, die die Bestimmung spezifischer IgE-Antikörper gegen die Allergene Api m 1, Ves v 1, Ves v 5 und Pol d 5 sowie kreuzreaktive Kohlenhydratdeterminanten (CCDs) erlaubt. Hierdurch soll vor allem bei Probanden mit Doppelsensibilisierungen die klinische Relevanz der einzelnen Sensibilisierungen besser beurteilt werden können...
May 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28485856/neue-laser-und-strahlquellen-alte-und-neue-risiken
#9
REVIEW
Uwe Paasch, Antje Schwandt, Nikolaus Seeber, Gerd Kautz, Sonja Grunewald, Merete Haedersdal
Die Entwicklungen im Bereich dermatologischer Laser, hochenergetischer Blitzlampen, LED und neuer Energie- und Strahlquellen der letzten Jahre haben gezeigt, dass mit neuen Wellenlängen, Konzepten und Kombinationen zusätzliche, zum Teil über den ästhetischen Bereich hinaus gehende therapeutische Optionen für den Dermatologen erschlossen werden konnten. Wurden bisher zum Beispiel mit fraktionalen Lasern Falten behandelt, sind eben diese Systeme heute in Kombination mit Medikamenten wichtige Werkzeuge bei der Behandlung von Narben, bei Feldkanzerisierung und epithelialen Tumoren...
May 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28460374/ldl-particle-number-and-size-and-cardiovascular-risk-anything-new-under-the-sun
#10
Janie Allaire, Cécile Vors, Patrick Couture, Benoît Lamarche
PURPOSE OF REVIEW: We provide here an up-to-date perspective on the potential use of LDL particle number and size as complementary risk factors to predict and manage cardiovascular disease (CVD) risk in the clinical realm. RECENT FINDINGS: Studies show that a significant proportion of the population has discordant LDL particle number and cholesterol indices [non-HDL cholesterol (HDL-C)]. Data also show that risk prediction may be improved when using information on LDL particle number in patients with discordant particle number and cholesterol data...
June 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28457586/adaptation-of-the-vertical-vestibulo-ocular-reflex-in-cats-during-low-frequency-vertical-rotation
#11
Hiroaki Fushiki, Motoyoshi Maruyama, Hideo Shojaku
OBJECTIVE: We examined plastic changes in the vestibulo-ocular reflex (VOR) during low-frequency vertical head rotation, a condition under which otolith inputs from the vestibular system are essential for VOR generation. METHODS: For adaptive conditioning of the vertical VOR, 0.02Hz sinusoidal pitch rotation for one hour about the earth's horizontal axis was synchronized with out-of-phase vertical visual stimulation from a random dot pattern. RESULTS: A vertical VOR was well evoked when the upright animal rotated around the earth-horizontal axis (EHA) at low frequency due to the changing gravity stimulus and dynamic stimulation of the otoliths...
April 27, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28444617/computational-theory-underlying-acute-vestibulo-ocular-reflex-motor-learning-with-cerebellar-long-term-depression-and-long-term-potentiation
#12
Keiichiro Inagaki, Yutaka Hirata
The vestibulo-ocular reflex (VOR) can be viewed as an adaptive control system that maintains compensatory eye movements during head motion. As the cerebellar flocculus is intimately involved in this adaptive motor control of the VOR, the VOR has been a popular model system for investigating cerebellar motor learning. Long-term depression (LTD) and long-term potentiation (LTP) at the parallel fiber-Purkinje cell synapses are considered to play major roles in cerebellar motor learning. A recent study using mutant mice demonstrated cerebellar motor learning with hampered LTD; the study concluded that the parallel fiber-Purkinje cell LTD is not essential...
April 25, 2017: Cerebellum
https://www.readbyqxmd.com/read/28436631/-video-head-impulse-test-for-evaluation-of-vestibular-function-in-patients-with-vestibular-neuritis-and-benign-paroxysmal-positional-vertigo
#13
Qiongfeng Guan, Lisan Zhang, Wenke Hong, Yi Yang, Zhaoying Chen, Dan Zhang, Xingyue Hu
Objective: To assess the clinical application of video head impulse test (vHIT) for vestibular function in vestibular neuritis (VN) and benign paroxysmal positional vertigo (BPPV) patients. Methods: Thirty-three patients with VN and 43 patients with BPPV were enrolled from Sir Run Run Shaw Hospital and Ningbo Second Hospital from March 15 to September 10, 2015; and 50 healthy controls were also enrolled in the study. vHIT was used to quantitatively test the vestibulo-ocular reflex (VOR) gains of a pair of horizontal semicircular canals...
January 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28434022/effects-of-vestibular-disorders-on-vestibular-reflex-and-imagery
#14
B S Cohen, J Provasi, P Leboucher, I Israël
The aim of this study was to establish the effect of vestibular lesion on vestibular imagery. Subjects were required to estimate verbally their passively travelled rotation angles in complete darkness, i.e., to activate vestibular imagery. During motion, the vestibulo-ocular reflex (VOR) was measured. Thus, we examined the coherence between the vestibulo-ocular reflex and self-rotation imagery, with vestibular-lesioned patients and healthy participants. Unilateral acute and chronic patients, bilateral patients, and healthy subjects were compared...
April 22, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28431905/dynamic-interhemispheric-competition-and-vestibulo-cortical-control-in-humans-a-theoretical-proposition
#15
REVIEW
Qadeer Arshad
Neuroscientific research has made a concerted effort to determine cortical localization using various functional imaging techniques. This approach has undoubtedly yielded important novel anatomical knowledge, albeit at times contradictory, regarding the structural organization of the vestibular cortex. Unfortunately however, this knowledge has not translated to our understanding regarding how neural mechanisms control vestibular function. Based upon recent functional imaging, lesion and neuro-physiological data that have demonstrated (i) the close behavioral and neuro-anatomical relationship between cortical processing of vestibular and spatial attention signals, and (ii) that inducing interhemispheric competition can in-turn strongly modulate vestibular function akin to that observed in cortical lesion patients, I herewith propose the hypothesis that vestibular cortical processing is controlled, as per for spatial attention, via dynamic interhemispheric competition...
April 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28404827/new-insights-into-vestibular-saccade-interaction-based-on-covert-corrective-saccades-in-patients-with-unilateral-vestibular-deficits
#16
Paolo Colagiorgio, Maurizio Versino, Silvia Colnaghi, Silvia Quaglieri, Marco Manfrin, Ewa Zamaro, Georgios Mantokoudis, David S Zee, Stefano Ramat
In response to passive high-acceleration head impulses patients with low vestibulo-ocular reflex (VOR) gains often produce covert (executed while the head is still moving) corrective saccades in the direction of deficient slow phases. Here we examined 23 patients using passive, and nine also active, head impulses with acute (< 10 days from onset) unilateral vestibular neuritis and low VOR gains. We found that when corrective saccades are larger than 10°, the slow-phase component of the VOR is inhibited, even though inhibition increases further the time to reacquire the fixation target...
April 12, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28393118/postural-compensation-strategy-depends-on-the-severity-of-vestibular-damage
#17
Lara A Thompson, Csilla Haburcakova, Richard F Lewis
The purpose of this study was to investigate the effects of various levels of vestibular function on balance in two, free-standing rhesus monkeys. We hypothesized that postural control strategy depended on the severity of vestibular damage. More specifically, that increased muscle stiffness (via short-latency mechanisms) was adequate to compensate for mild damage, but long-latency mechanisms must be utilized for more severe vestibular damage. One animal was studied for pre-ablated and mild vestibular dysfunction states, while a second animal was studied in a pre-ablated and severe vestibular dysfunction state...
March 2017: Heliyon
https://www.readbyqxmd.com/read/28386500/diagnostic-bedside-vestibuloocular-reflex-evaluation-in-the-setting-of-a-false-negative-fistula-test-in-cholesteatoma-of-the-middle-ear
#18
Ricardo D'Albora, Ligia Silveira, Sergio Carmona, Nicolas Perez-Fernandez
Background. False negative fistula testing in patients with chronic suppurative otitis media is a dilemma when proceeding to surgery. It is imperative to rule out a dead labyrinth or a mass effect secondary to the cholesteatoma in an otherwise normally functioning inner ear. We present a case series of three patients in whom a bedside vestibuloocular reflex (VOR) evaluation using a head impulse test was used successfully for further evaluation prior to surgery. Results. In all three cases with a false negative fistula test we were able to further evaluate at the bedside and were not only able to register the abnormal VOR but also localize its deterioration to a particular semicircular canal eroded by the fistula...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28380076/strength-of-baseline-inter-trial-correlations-forecasts-adaptive-capacity-in-the-vestibulo-ocular-reflex
#19
Kara H Beaton, Aaron L Wong, Steven B Lowen, Mark Shelhamer
Individual differences in sensorimotor adaptability may permit customized training protocols for optimum learning. Here, we sought to forecast individual adaptive capabilities in the vestibulo-ocular reflex (VOR). Subjects performed 400 head-rotation steps (400 trials) during a baseline test, followed by 20 min of VOR gain adaptation. All subjects exhibited mean baseline VOR gain of approximately 1.0, variable from trial to trial, and showed desired reductions in gain following adaptation with variation in extent across individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28378469/die-histologischen-typen-der-lymphomatoiden-papulose-ein-vorschlag-f%C3%A3-r-die-vereinfachung-des-buchstabenchaos
#20
REVIEW
Werner Kempf, Christina Mitteldorf, Laszlo J Karai, Alistair Robson
Die lymphomatoide Papulose (LYP) ist klinisch durch rezidivierende papulonoduläre Läsionen charakterisiert. Im Gegensatz zu dieser stereotypen klinischen Präsentation zeigt die Erkrankung ein breites histologisches Spektrum mit verschiedenen Infiltratmustern, unterschiedlichen Tumorzellgrößen und variablen Phänotypen. Die revidierte WHO-Klassifikation 2016 umfasst die histologischen LYP-Typen A bis E und einen sechsten Typ, dem eine spezielle Mutation zugrunde liegt. Darüber hinaus werden jedoch immer wieder neue Typen vorgeschlagen, wobei sich die Ausweitung nicht ausschließlich auf histologische Muster bezieht, sondern sich auch auf klinische und genetische Aspekte ausdehnt...
April 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
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