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https://www.readbyqxmd.com/read/28318060/integrating-postural-and-vestibular-dimensions-to-depict-impairment-in-moderate-to-severe-obstructive-sleep-apnea-syndrome-patients
#1
Alessandro Micarelli, Claudio Liguori, Andrea Viziano, Francesca Izzi, Fabio Placidi, Marco Alessandrini
Vestibular dysfunction was linked to moderate-to-severe obstructive sleep apnea syndrome (OSAS) patients in literature. However, due to a lack of knowledge among valid and recent implementations conceived to study postural control on static posturography (SP) and vestibulo-ocular reflex (VOR) gain under physiological conditions (video Head Impulse Test; vHIT), the aim of this work was to integrate (i) VOR changes via vHIT implementation, (ii) postural arrangement by studying both classical parameters and frequency spectra (PS) and (iii) correlation between these findings, polygraphic (PG) and subjective scores along Dizziness Handicap Inventory (DHI) and Epworth Sleepiness Scale (ESS)...
March 20, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28303261/long-lasting-visuo-vestibular-mismatch-in-freely-behaving-mice-reduces-the-vestibulo-ocular-reflex-and-leads-to-neural-changes-in-the-direct-vestibular-pathway
#2
Julie Carcaud, Filipa França de Barros, Erwin Idoux, Daniel Eugène, Lionel Reveret, Lee E Moore, Pierre-Paul Vidal, Mathieu Beraneck
Calibration of the vestibulo-ocular reflex (VOR) depends on the presence of visual feedback. However, the cellular mechanisms associated with VOR modifications at the level of the brainstem remain largely unknown. A new protocol was designed to expose freely behaving mice to a visuo-vestibular mismatch during a 2-week period. This protocol induced a 50% reduction of the VOR. In vivo pharmacological experiments demonstrated that the VOR reduction depends on changes located outside the flocculus/paraflocculus complex...
January 2017: ENeuro
https://www.readbyqxmd.com/read/28292832/functional-organization-of-vestibulo-ocular-responses-in-abducens-motoneurons
#3
Haike Dietrich, Stefan Glasauer, Hans Straka
Vestibulo-ocular reflexes (VOR) are the dominating contributors to gaze stabilization in all vertebrates. During horizontal head movements, abducens motoneurons form the final element of the reflex arc that integrates visuo-vestibular inputs into temporally precise motor commands for the lateral rectus eye muscle. Here, we studied a possible differentiation of abducens motoneurons into subtypes by evaluating their morphology, discharge properties and synaptic pharmacology in semi-intact in vitro preparations of larval Xenopus laevis Extracellular nerve recordings during sinusoidal head motion revealed a continuum of resting rates and activation thresholds during vestibular stimulation...
March 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28292626/intratympanal-gentamicin-in-meniere-s-disease-effects-on-individual-semicircular-canals
#4
Béla Büki, Heinz Jünger
OBJECTIVE: In this retrospective study the aim of the authors was to examine the effect of gentamicin on the individual semicircular canals after low dose, single injection intratympanal gentamicin therapy in Meniere's disease. METHODS: Data of 32 patients treated between 2011 and 2015 were collected. The high frequency, high acceleration vestibuloocular reflex (VOR) gain was measured in the individual semicircular canals using video head impulse test immediately before the first intratympanal gentamicin instillation and approximately two months later...
March 11, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28282366/comparing-azole-plasma-trough-levels-in-lung-transplant-recipients-percentage-of-therapeutic-levels-and-intrapatient-variability
#5
Daniela Stelzer, Alexandra Weber, Franziska Ihle, Sandhya Matthes, Felix Ceelen, Gregor Zimmermann, Nikolaus Kneidinger, Rene Schramm, Hauke Winter, Michael Zoller, Michael Vogeser, Juergen Behr, Claus Neurohr
BACKGROUND: This study compared therapeutic azole plasma trough levels (APL) of the azole antimycotics itraconazole (ITR), voriconazole (VOR), and posaconazole (POS) in lung transplant recipients and analyzed the influencing factors. In addition, intrapatient variability for each azole was determined. METHODS: From July 2012 to July 2015, 806 APL of ITR, VOR, posaconazole liquid (POS-Liq), and posaconazole tablets (POS-Tab) were measured in 173 patients of the Munich Lung Transplantation Program...
April 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28277861/state-transition-model-vorapaxar-added-to-standard-antiplatelet-therapy-to-prevent-thrombosis-post-myocardial-infarction-or-peripheral-artery-disease
#6
Mark Du, Monica Chase, Mustafa Oguz, Glenn Davies
OBJECTIVE: To evaluate long-term health benefits and risks of adding vorapaxar (VOR) to the standard care antiplatelet therapy (SC) of aspirin and/or clopidogrel, among a population with a recent myocardial infarction (MI) and/or peripheral artery disease (PAD). RESEARCH DESIGN AND METHODS: In a state-transition model, patients transition between health states (event-free, recurrent MI, stroke, death), while at risk of experiencing non-transition-related revascularization and non-fatal bleeding events...
March 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28252862/dermatologische-tageskliniken-vor-dem-hintergrund-der-aktuellen-gesetzgebung-zur-krankenhausfinanzierung
#7
Volker Blaschke, Birka Brauns, Christian Schmidt, Steffen Emmert
No abstract text is available yet for this article.
March 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28252853/pathogenese-von-wundheilungsst%C3%A3-rungen-bei-%C3%A3-lteren-patienten
#8
Evgenia Makrantonaki, Meinhard Wlaschek, Karin Scharffetter-Kochanek
Ältere Menschen sind für Wundheilungsstörungen und chronische Wunden am anfälligsten, insbesondere für venöse Beinulzera, Dekubitalulzera und diabetische Fußulzera. Jedoch sollten bei der diagnostischen Abklärung chronischer Wunden weitere altersassoziierte Krankheiten in Betracht gezogen werden. Ein besseres Verständnis der an Wundheilungsstörungen beteiligten Pathomechanismen ist wichtig für die Bewältigung der Schwierigkeiten bei der Behandlung chronischer Wunden. In den letzten Jahrzehnten wurden beachtliche Fortschritte bei zukunftsweisenden Therapien chronischer Wunden erzielt...
March 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28252851/die-bedeutung-der-blauen-farbe-in-der-dermatoskopie
#9
Mirjana Popadić, Christoph Sinz, Harald Kittler
HINTERGRUND UND ZIELE: Hautläsionen mit blauer Färbung werden häufig chirurgisch entfernt, um Malignität auszuschließen zu können. Das Ziel der vorliegenden Studie war es, die Bedeutung der blauen Färbung zu untersuchen. METHODEN: Wir untersuchten dermatoskopische Bilder retrospektiv auf blaue Farbe und klassifizierten sie gemäß der Musteranalyse. ERGEBNISSE: Von 1.123 pigmentierten Hautläsionen wiesen 144 (12,8 %) eine blaue Färbung auf...
March 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28240521/morphological-classification-of-intraductal-papillary-neoplasm-of-the-bile-duct-with-survival-correlation
#10
Vor Luvira, Kulyada Somsap, Ake Pugkhem, Chalerm Eurboonyanun, Varisara Luvira, Vajarabhongsa Bhudhisawasdi, Chawalit Pairojkul, Supot Kamsa Ard
Background: Intraductal papillary neoplasm of the bile duct (IPNB) is a specific entity for which there has been no classification that correlates clinical presentation with patient survival. We, therefore, propose a new classification based on radio-pathological appearance correlated with clinical findings including outcome. Methods: We retrospectively reviewed the medical and pathological records of 103 IPNB patients who underwent curative-intent hepatic resection between January 2008 and December 2011. A morphological classification was then created based on the presence of (a) bile duct dilatation, (b) intraductal mass(es), (c) cystic lesion(s), and (d) macro-invasion of the liver...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28222465/autologous-conditioned-plasma-versus-placebo-injection-therapy-in-lateral-epicondylitis-of-the-elbow-a-double-blind-randomized-study
#11
Volker Schöffl, Wolfgang Willauschus, Felix Sauer, Thomas Küpper, Isabelle Schöffl, Christoph Lutter, Kolja Gelse, Jörg Dickschas
Introduction There are various therapeutic approaches to the treatment of lateral epicondylitis, a highly prevalent musculoskeletal disorder. Recently, injection therapy with autologous conditioned plasma (ACP) has shown promise as a new approach. Methods Set up as a prospective, double-blind, randomized controlled clinical trial, this study involved 50 patients with lateral epicondylitis. Following external randomization, 25 patients received one round of injection therapy with ACP (platelet rich plasma, PRP), while the remaining 25 patients received a placebo of 0...
February 21, 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/28214309/wirksamkeit-und-sicherheit-von-fumars%C3%A3-ureestern-in-kombination-mit-phototherapie-bei-patienten-mit-moderater-bis-schwerer-plaque-psoriasis-fast
#12
Peter Weisenseel, Kristian Reich, Wiebke Griemberg, Katharina Merten, Christine Gröschel, Natalie Nunez Gomez, Kirsi Taipale, Beate Bräu, Ina Zschocke
HINTERGRUND: Die Behandlung von Psoriasis-Patienten mit einer Kombination aus Fumarsäureestern (FSE, Fumaderm(®) ) und Phototherapie (UV) ist verbreitet, wurde aber im Rahmen von Studien wenig untersucht. Bisher liegen lediglich Daten aus einer kleinen Pilotstudie vor. Intention dieser Studie war, eine FSE/UV-Kombinationsbehandlung an einem größeren Patientenkollektiv mit mittelschwerer bis schwerer Psoriasis zu untersuchen. PATIENTEN UND METHODIK: In dieser prospektiven, multizentrischen, nichtinterventionellen Studie wurden Daten von Patienten mit FSE/UV-Kombinationstherapie hinsichtlich der Wirksamkeit (PGA' PASI, DLQI, EQ-5D), Sicherheit und Dosierung über einen Zeitraum von zwölf Monaten erfasst und mit Daten einer retrospektiven Studie mit FSE-Monotherapie verglichen...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28194135/inaccurate-saccades-and-enhanced-vestibulo-ocular-reflex-suppression-during-combined-eye-head-movements-in-patients-with-chronic-neck-pain-possible-implications-for-cervical-vertigo
#13
Janine L Johnston, Pierre M Daye, Glen T D Thomson
BACKGROUND: The primate ocular motor system is designed to acquire peripheral targets of interest by coordinating visual, vestibular, and neck muscle activation signals. The vestibulo-ocular reflex (VOR) is greatly reduced at the onset of large eye-head (gaze) saccades and resumes before the end of the saccades to stabilize eye-in-orbit and ensure accurate target acquisition. Previous studies have relied on manipulating head movements in normal individuals to study VOR suppression and gaze kinematics...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28192379/compensatory-saccades-are-associated-with-physical-performance-in-older-adults-data-from-the-baltimore-longitudinal-study-of-aging
#14
Yanjun Xie, Eric R Anson, Eleanor M Simonsick, Stephanie A Studenski, Yuri Agrawal
OBJECTIVE: To determine whether compensatory saccade metrics observed in the video head impulse test, specifically saccade amplitude and latency, predict physical performance. STUDY DESIGN: Cross-sectional analysis of the Baltimore Longitudinal Study of Aging, a prospective cohort study. SETTING: National Institute on Aging Intramural Research Program Clinical Research Unit in Baltimore, Maryland. PATIENTS: Community-dwelling older adults...
March 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28179894/vestibulo-ocular-reflex-stabilization-after-vestibular-schwannoma-surgery-a-story-told-by-saccades
#15
Angel Batuecas-Caletrio, Jorge Rey-Martinez, Gabriel Trinidad-Ruiz, Eusebi Matiño-Soler, Santiago Santa Cruz-Ruiz, Angel Muñoz-Herrera, Nicolas Perez-Fernandez
OBJECTIVE: To evaluate vestibular compensation via measurement of the vestibulo-ocular reflex (VOR) following vestibular schwannoma surgery and its relationship with changes in saccades strategy after surgery. PATIENTS: Thirty-six consecutive patients with vestibular schwannomas, without brainstem compression, underwent surgical resection. Patients were recruited from University Hospital of Salamanca, Spain. METHODS: We assessed the age, sex, tumor size, degree of canalicular weakness, and preoperative video head impulse test (gain and saccade organization measured with PR score)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28178036/can-the-video-head-impulse-test-define-severity-of-bilateral-vestibular-hypofunction
#16
Paul D Judge, Kristen L Janky, Kamran Barin
OBJECTIVE: The objective of the study was to compare rotary chair and video head impulse test (vHIT) findings in patients with bilateral vestibular hypofunction (BVH) to determine whether vHIT can: 1) define severity of BVH and 2) accurately predict rotary chair findings in patients with BVH. STUDY DESIGN: Retrospective chart review. SETTING: Research hospital. PATIENTS: Twenty subjects with bilateral vestibular hypofunction as assessed by rotary chair...
January 7, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28140545/spitzn%C3%A3-vi-unterschiedliche-klinische-dermatoskopische-und-histopathologische-merkmale-in-der-kindheit
#17
Emi Dika, Iria Neri, Pier Alessandro Fanti, Alessia Barisani, Giulia Maria Ravaioli, Annalisa Patrizi
HINTERGRUND UND ZIELE: Die Charakterisierung der klinischen Merkmale und des biologischen Potenzials von Spitznävi hat in den letzten Jahrzehnten breites Interesse gefunden. Das Ziel dieser Arbeit ist die Beschreibung der klinischen und dermatoskopischen Merkmale von Spitznävi sowie des klinischen Ergebnisses nach chirurgischer Exzision von Spitznävi in drei pädiatrischen Altersgruppen. PATIENTEN UND METHODEN: Restrospektive Studie zur Analyse von klinischen Merkmalen, videodermatoskopischen Bildern, histopathologischen Diagnosen und Behandlungsergebnissen...
January 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28140542/therapieoptionen-beim-pyoderma-gangraenosum
#18
REVIEW
Sven R Quist, Luise Kraas
Das Pyoderma gangraenosum (PG) gehört zu den orphan diseases, deren Erforschung sich lediglich auf einzelne, randomisierte, multizentrische sowie retrospektive Studien stützen kann und überwiegend auf Fallserien an kleinen Patientenkollektiven beruht. Die Therapie basiert neben topischen und lokal intraläsionalen Therapieoptionen, bei initialem und leichtem Krankheitsverlauf, insbesondere auf der Gabe von Systemtherapeutika. Diese beinhaltet neben den systemischen Glukokortikosteroiden und Ciclosporin A (CsA) auch Biologika wie intravenöses Immunglobulin G (IVIG), die TNFα-Inhibitoren Infliximab, Adalimumab und Etanercept, den IL-12/23-Antikörper Ustekinumab, den Interleukin-1-Rezeptorantagonist Anakinra und den Interleukin-1β-Antikörper Canakinumab...
January 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28140533/kombinierte-hoch-niedrig-dosis-therapie-mit-systemischen-glukokor-tikoiden-bei-schweren-verlaufsformen-der-alopecia-areata-im-kindesalter
#19
Karin Jahn-Bassler, Wolfgang Michael Bauer, Franz Karlhofer, Matthias G Vossen, Georg Stingl
HINTERGRUND: Schwere Verlaufsformen der Alopecia areata (AA) im Kindesalter sind aufgrund limitierter Optionen therapeutisch herausfordernd. Systemische, hochdosierte Glukokortikoide weisen die schnellste Ansprechrate auf, nach dem Absetzen kommt es allerdings zu Rezidiven. Eine längerfristige Hochdosis-Anwendung ist aufgrund der zu erwartenden Nebenwirkungen nicht empfehlenswert. Eine dauerhafte Steroiderhaltungstherapie unterhalb der Cushing-Schwellen-Dosis nach Bolustherapie könnte die Krankheitsaktivität ohne Nebenwirkungen längerfristig unterdrücken...
January 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28131045/inflammatory-gene-expression-in-whole-blood-cells-after-epa-vs-dha-supplementation-results-from-the-compared-study
#20
Cécile Vors, Janie Allaire, Johanne Marin, Marie-Claude Lépine, Amélie Charest, André Tchernof, Patrick Couture, Benoît Lamarche
BACKGROUND AND AIMS: Whether EPA and DHA exert similar anti-inflammatory effects through modulation of gene expression in immune cells remains unclear. The aim of the study was to compare the impact of EPA and DHA supplementation on inflammatory gene expression in subjects at risk for cardiometabolic diseases. METHODS: In this randomized double-blind crossover trial, 154 men and women with abdominal obesity and low-grade inflammation were subjected to three 10-wk supplementation phases: 1) EPA (2...
February 2017: Atherosclerosis
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