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https://www.readbyqxmd.com/read/29147731/the-influence-of-cervical-movement-on-eye-stabilization-reflexes-a-randomized-trial
#1
Britta K Ischebeck, Jurryt de Vries, Jan Paul van Wingerden, Gert Jan Kleinrensink, Maarten A Frens, Jos N van der Geest
To investigate the influence of the amount of cervical movement on the cervico-ocular reflex (COR) and vestibulo-ocular reflex (VOR) in healthy individuals. Eye stabilization reflexes, especially the COR, are changed in neck pain patients. In healthy humans, the strength of the VOR and the COR are inversely related. In a cross-over trial the amplitude of the COR and VOR (measured with a rotational chair with eye tracking device) and the active cervical range of motion (CROM) was measured in 20 healthy participants (mean age 24...
November 17, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29143209/the-medial-vestibular-nuclei-a-vulnerable-target-in-thiamine-deficiency
#2
Jorge C Kattah, Cindy Guede, Bahareh Hassanzadeh
BACKGROUND: Bilateral medial vestibular nuclei (MVN) is a common target in thiamine depletion and results in acute vestibular failure. Involvement of the MVN was present in 27 out of 38 brainstem sections reported in the largest thiamine deficiency autopsy cohort with Wernicke's encephalopathy. METHOD: Serial clinical, imaging and vestibulo-ocular reflex gain measured with the video head impulse (vHIT) in one patient with acute thiamine deficiency. RESULTS: Low horizontal VOR gain correlated with an abnormal manual head impulse and with MRI evidence of MVN in an alcohol-dependent patient with low thiamine levels...
November 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29142084/impaired-vestibular-responses-in-internuclear-ophthalmoplegia-association-and-dissociation
#3
Seo-Young Choi, Hyo-Jung Kim, Ji-Soo Kim
OBJECTIVE: To determine the role of the medial longitudinal fasciculus (MLF) in conveying vestibular signals. METHODS: In 10 patients with isolated acute unilateral internuclear ophthalmoplegia (INO) due to an acute stroke, we performed comprehensive vestibular evaluation using video-oculography, head impulse tests with a magnetic search coil technique, bithermal caloric tests, tests for the ocular tilt reaction, and measurements of subjective visual vertical and cervical and ocular vestibular evoked myogenic potentials (VEMPs)...
November 15, 2017: Neurology
https://www.readbyqxmd.com/read/29135873/the-effect-of-peripheral-vestibular-recovery-on-improvements-in-vestibulo-ocular-reflexes-and-balance-control-after-acute-unilateral-peripheral-vestibular-loss
#4
John H J Allum, Alja Scheltinga, Flurin Honegger
BACKGROUND: Patients with an acute unilateral peripheral vestibular deficit (aUPVD), presumed to be caused by vestibular neuritis, show asymmetrical vestibular ocular reflexes (VORs) that improve over time. Questions arise regarding how much of the VOR improvement is due to peripheral recovery or central compensation, and whether differences in peripheral recovery influence balance control outcomes. METHODS: Thirty patients were examined at aUPVD onset and 3, 6, and 13 weeks later with four different VOR tests: caloric tests; rotating (ROT) chair tests performed in yaw with angular accelerations of 5 and 20 degrees/s; and video head impulse tests (vHIT) in the yaw plane...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29133513/phase-ii-study-of-bevacizumab-and-vorinostat-for-patients-with-recurrent-world-health-organization-grade-4-malignant-glioma
#5
Ashley Ghiaseddin, David Reardon, Woody Massey, Alex Mannerino, Eric S Lipp, James E Herndon, Frances McSherry, Annick Desjardins, Dina Randazzo, Henry S Friedman, Katherine B Peters
LESSONS LEARNED: Combination regimen with bevacizumab (BEV) and vorinostat is well tolerated in patients with recurrent glioblastoma.Treatment of recurrent glioblastoma remains challenging as this study and others attempt to improve progression-free survival and overall survival with BEV-containing regimens. BACKGROUND: Recurrent glioblastoma (GBM; World Health Organization grade 4) continues to have a very poor prognosis. Bevacizumab (BEV) has been shown to improve progression-free survival (PFS) in recurrent GBM and is approved by the U...
November 13, 2017: Oncologist
https://www.readbyqxmd.com/read/29110135/the-effect-of-visual-contrast-on-human-vestibulo-ocular-reflex-adaptation
#6
M Muntaseer Mahfuz, Michael C Schubert, Christopher J Todd, William V C Figtree, Serajul I Khan, Americo A Migliaccio
The vestibulo-ocular reflex (VOR) is the main retinal image stabilising mechanism during rapid head movement. When the VOR does not stabilise the world or target image on the retina, retinal image slip occurs generating an error signal that drives the VOR response to increase or decrease until image slip is minimised, i.e. VOR adaptation occurs. Visual target contrast affects the human smooth pursuit and optokinetic reflex responses. We sought to determine if contrast also affected VOR adaptation. We tested 12 normal subjects, each over 16 separate sessions...
November 6, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29081426/bilateral-vestibulopathy-diagnostic-criteria-consensus-document-of-the-classification-committee-of-the-b%C3%A3-r%C3%A3-ny-society
#7
Michael Strupp, Ji-Soo Kim, Toshihisa Murofushi, Dominik Straumann, Joanna C Jen, Sally M Rosengren, Charles C Della Santina, Herman Kingma
This paper describes the diagnostic criteria for bilateral vestibulopathy (BVP) by the Classification Committee of the Bárány Society. The diagnosis of BVP is based on the patient history, bedside examination and laboratory evaluation. Bilateral vestibulopathy is a chronic vestibular syndrome which is characterized by unsteadiness when walking or standing, which worsen in darkness and/or on uneven ground, or during head motion. Additionally, patients may describe head or body movement-induced blurred vision or oscillopsia...
2017: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29064869/vision-and-vestibular-system-dysfunction-predicts-prolonged-concussion-recovery-in-children
#8
Christina L Master, Stephen R Master, Douglas J Wiebe, Eileen P Storey, Julia E Lockyer, Olivia E Podolak, Matthew F Grady
OBJECTIVE: Up to one-third of children with concussion have prolonged symptoms lasting beyond 4 weeks. Vision and vestibular dysfunction is common after concussion. It is unknown whether such dysfunction predicts prolonged recovery. We sought to determine which vision or vestibular problems predict prolonged recovery in children. DESIGN: A retrospective cohort of pediatric patients with concussion. SETTING: A subspecialty pediatric concussion program...
October 20, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29064828/differences-in-head-impulse-test-results-due-to-analysis-techniques
#9
Taylor W Cleworth, Mark G Carpenter, Flurin Honegger, John H J Allum
BACKGROUND: Different analysis techniques are used to define vestibulo-ocular reflex (VOR) gain between eye and head angular velocity during the video head impulse test (vHIT). Comparisons would aid selection of gain techniques best related to head impulse characteristics and promote standardisation. OBJECTIVE: Compare and contrast known methods of calculating vHIT VOR gain. METHODS: We examined lateral canal vHIT responses recorded from 20 patients twice within 13 weeks of acute unilateral peripheral vestibular deficit onset...
2017: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29064824/uncoupling-vor-and-vestibuloautonomic-retention-to-coriolis-acceleration-training-in-student-pilots-and-control-subjects
#10
Linjie Wang, Yi Cao, Cheng Tan, Qi Zhao, Siyang He, Dongbin Niu, Guohua Tang, Peng Zou, Lei Xing
PURPOSE: Explore the different vestibular physiologic response retention patterns after Coriolis acceleration training in student pilots and extend the results for use with Chinese astronauts in the future. METHODS: Twelve healthy control male subjects were screened from males familiar with vestibular training and who physically resembled the astronauts. Fourteen student pilots were selected from 23 participants by rotational vestibular function tests. All subjects were exposed to five-day continuous or intermittent Coriolis acceleration training...
2017: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29018402/preferential-impairment-of-the-contralesional-posterior-semicircular-canal-in-internuclear-ophthalmoplegia
#11
Seung-Han Lee, Sang-Hoon Kim, Sung-Sik Kim, Kyung Wook Kang, Alexander Andrea Tarnutzer
BACKGROUND: The vertical vestibulo-ocular reflex (VOR) may be impaired in internuclear ophthalmoplegia (INO) as the medial longitudinal fasciculus (MLF) conveys VOR-signals from the vertical semicircular canals. It has been proposed that signals from the contralesional posterior semicircular canal (PSC) are exclusively transmitted through the MLF, while for the contralesional anterior canal other pathways exist. OBJECTIVE: Here, we aimed to characterize dysfunction in individual canals in INO-patients using the video-head-impulse test (vHIT) and to test the hypothesis of dissociated vertical canal impairment in INO...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28992385/synthesis-of-mono-and-bis-fluoroalkyl-pyrimidines-from-fars-fluorinated-acetoacetates-and-malononitrile-easy-access-to-novel-high-value-pyrimidine-scaffolds
#12
Etienne Schmitt, Bruno Commare, Armen Panossian, Jean-Pierre Vors, Sergiy Pazenok, Frédéric R Leroux
A new strategy was developed using fluorinated acetoacetates, malononitrile and Fluoroalkyl Amino Reagents (FARs) in order to access unprecedented 4,6-bis(fluoroalkyl)-pyrimidine-5-carboxylates, their carboxylic acid analogues and 4-amino-6-(fluoroalkyl)-pyrimidine-5-carbonitriles. An efficient cyclization step using suitable amidines was developed under microwave irradiation, providing rapidly and efficiently the desired pyrimidines. Standard saponification conditions were applied from carboxylate derivatives to access to the corresponding carboxylic acids...
October 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28985517/effect-of-common-antivertiginous-agents-on-the-high-velocity-vestibulo-ocular-reflex
#13
E Anagnostou, P Koutsoudaki, A Stavropoulos, I Evdokimidis
OBJECTIVE: It has long been suggested that antivertiginous medications exert their symptomatic effect through inhibition of the vestibulo-ocular reflex (VOR). We tested this hypothesis by directly measuring the VOR after administration of three agents from different substance classes: an antihistamine, a benzodiazepine and a calcium channel antagonist. METHODS: The gain and the variability of the high velocity VOR was assessed using video head impulses (vHIT) under the following conditions: baseline, after dimenhydrinate, after diazepam and after cinnarizine...
September 19, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28955674/vestibulo-ocular-reflex-abnormalities-in-posterior-semicircular-canal-benign-paroxysmal-positional-vertigo-a-pilot-study
#14
Tayyebe Fallahnezhad, Mansoureh Adel Ghahraman, Saeid Farahani, Reza Hoseinabadi, Shohreh Jalaie
INTRODUCTION: Benign paroxysmal positional vertigo (BPPV), involving the semicircular canals, is one of the most common diseases of the inner ear. The video head impulse test (vHIT) is a new test that examines the function of the canals. This study aimed to investigate the vestibulo-ocular reflex (VOR) gain, gain asymmetry and saccades after stimulating all six canals in patients definitively diagnosed with posterior semicircular canal BPPV (PSC-BPPV). MATERIALS AND METHODS: Twenty-nine unilateral PSC-BPPV patients with normal oculographic and caloric results were enrolled in this study...
September 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28949274/determination-of-the-time-course-of-caloric-nystagmus-in-patients-with-spinocerebellar-degeneration-using-caloric-step-stimulus-procedure
#15
Takamori Takeda, Ayane Makabe, Chiaki Hirai, Takeshi Tsutsumi
CONCLUSIONS: The step stimulus procedure can provide information on the time course of the vestibulo-ocular reflex. Spinocerebellar degeneration and aging seem to shorten the time constant of the onset of the vestibulo-ocular reflex, causing a rapid rise up. Failure of the central processing of velocity storage might contribute to this rapid rise up. OBJECTIVES: The aim of this study is to evaluate the time course characteristics of the vestibulo-ocular reflex in patients with spinocerebellar degeneration...
September 26, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28948528/co-delivery-of-vorinostat-and-etoposide-via-disulfide-cross-linked-biodegradable-polymeric-nanogels-synthesis-characterization-biodegradation-and-anticancer-activity
#16
Parveen Kumar, Lubna Wasim, Madhu Chopra, Aruna Chhikara
Treatment regimens for cancer patients using single chemotherapeutic agents often lead to undesirable toxicity, drug resistance, reduced uptake etc. Combination of two or more drugs is therefore becoming an imperative strategy to overcome these limitations. A step forward can be taken through delivery of the drugs used in combination via nanoparticles. Co-administration of chemotherapeutic drugs encapsulated in nanoparticles has been shown to result in synergistic effects and enhanced therapeutic efficacy. In present study, we explored the combination treatment of histone deacetylase inhibitor vorinostat (VOR) and topoisomerase II inhibitor etoposide (ETOP)...
September 25, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28942480/acute-inhibition-of-estradiol-synthesis-impacts-vestibulo-ocular-reflex-adaptation-and-cerebellar-long-term-potentiation-in-male-rats
#17
Cristina V Dieni, Aldo Ferraresi, Jacqueline A Sullivan, Sivarosa Grassi, Vito E Pettorossi, Roberto Panichi
The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Purkinje cell (PF) synapse. To verify this hypothesis, we investigated the acute effect of blocking E2 synthesis on gain increases and decreases in adaptation of the VOR in male rats using an oral dose (2...
September 23, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28936193/video-head-impulse-tests-with-a-remote-camera-system-normative-values-of-semicircular-canal-vestibulo-ocular-reflex-gain-in-infants-and-children
#18
Sylvette R Wiener-Vacher, Sidney I Wiener
The video head impulse test (VHIT) is widely used to identify semicircular canal function impairments in adults. But classical VHIT testing systems attach goggles tightly to the head, which is not tolerated by infants. Remote video detection of head and eye movements resolves this issue and, here, we report VHIT protocols and normative values for children. Vestibulo-ocular reflex (VOR) gain was measured for all canals of 303 healthy subjects, including 274 children (aged 2.6 months-15 years) and 26 adults (aged 16-67)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28919878/postural-control-in-bilateral-vestibular-failure-its-relation-to-visual-proprioceptive-vestibular-and-cognitive-input
#19
Andreas Sprenger, Jann F Wojak, Nico M Jandl, Christoph Helmchen
Patients with bilateral vestibular failure (BVF) suffer from postural and gait unsteadiness with an increased risk of falls. The aim of this study was to elucidate the differential role of otolith, semicircular canal (SSC), visual, proprioceptive, and cognitive influences on the postural stability of BVF patients. Center-of-pressure displacements were recorded by posturography under six conditions: target visibility; tonic head positions in the pitch plane; horizontal head shaking; sensory deprivation; dual task; and tandem stance...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28895171/effect-of-aging-and-direction-of-impulse-in-video-head-impulse-test
#20
Tae Hwan Kim, Min-Beom Kim
OBJECTIVE: The aim of this study was to identify the difference of gain value in the video head impulse test (vHIT) according to the age of the patient and the direction of the impulse. METHOD: All participants were subjected to vHIT with horizontal semicircular canal (HSCC). vHIT with vertical canal (posterior and anterior semicircular canal [PSCC and ASCC]) additionally was performed in 434 participants. RESULTS: The mean vestibulo-ocular reflex (VOR) gain was maintained in patients in the HSCC at below 70 years (1...
September 12, 2017: Laryngoscope
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