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MMI and culture

Dotun Ogunyemi, Carolyn Alexander, Edward Tangchitnob, David Seil Kim
BACKGROUND: A robust selection process is critical to residents' "cultural fit" and success in their program. Traditional selection methods have shortcomings. OBJECTIVE: We describe a novel residency interview process for obstetrics-gynecology residents that incorporates behavioral, group, and surgical simulation multiple mini interviews (MMIs). METHODS: In 2010, the Cedars-Sinai Medical Center obstetrics-gynecology residency program developed surgical simulation, role play, ethics group interview, and Accreditation Council for Graduate Medical Education competency-based behavioral interview stations...
July 2016: Journal of Graduate Medical Education
Anne-Victoire Fayolle, Catherine Passirani, Elisabeth Letertre, Aline Ramond, Dominique Perrotin, Jean-Paul Saint-André, Isabelle Richard
CONTEXT: The number of applicants to medical school exceeds the number of places available, a situation that questions the effectiveness and relevance of medical student assessment and selection. OBJECTIVES: The objective of this review of the literature was to analyze in a systematic way the studies looking for an association between results of an admission procedure and a later evaluation of the characteristics of the students or the doctors that they became. DOCUMENTARY SOURCES (KEY WORDS AND LANGUAGE): MedLine, Web of Science and Cochrane Library...
May 2016: La Presse Médicale
Elana Curtis, Erena Wikaire, Yannan Jiang, Louise McMillan, Rob Loto, Airini, Papaarangi Reid
INTRODUCTION: Achieving health equity for indigenous and ethnic minority populations requires the development of an ethnically diverse health workforce. This study explores a tertiary admission programme targeting Māori and Pacific applicants to nursing, pharmacy and health sciences (a precursor to medicine) at the University of Auckland (UoA), Aotearoa New Zealand (NZ). Application of cognitive and non-cognitive selection tools, including a Multiple Mini Interview (MMI), are examined...
2015: International Journal for Equity in Health
Anuja Alapati, Sudhir P Deosarkar, Olivia L Lanier, Chunyan Qi, Grady E Carlson, Monica M Burdick, Frank L Schwartz, Kelly D McCall, Stephen C Bergmeier, Douglas J Goetz
The expression of vascular cell adhesion molecule-1 (VCAM-1) on the vascular endothelium can be increased by pro-inflammatory cytokines [e.g. tumor necrosis factor-α (TNF-α)]. VCAM-1 contributes to leukocyte adhesion to, and emigration from, the vasculature which is a key aspect of pathological inflammation. As such, a promising therapeutic approach for pathological inflammation is to inhibit the expression of VCAM-1. Methimazole [3-methyl-1, 3 imidazole-2 thione (MMI)] is routinely used for the treatment of Graves׳ disease and patients treated with MMI have decreased levels of circulating VCAM-1...
March 15, 2015: European Journal of Pharmacology
Maureen E Kelly, Jon Dowell, Adrian Husbands, John Newell, Siun O'Flynn, Thomas Kropmans, Fidelma P Dunne, Andrew W Murphy
BACKGROUND: International medical students, those attending medical school outside of their country of citizenship, account for a growing proportion of medical undergraduates worldwide. This study aimed to establish the fairness, predictive validity and acceptability of Multiple Mini Interview (MMI) in an internationally diverse student population. METHODS: This was an explanatory sequential, mixed methods study. All students in First Year Medicine, National University of Ireland Galway 2012 were eligible to sit a previously validated 10 station MMI...
2014: BMC Medical Education
Lei Xu, Cecelia C Yates, Pamela Lockyer, Liang Xie, Ariana Bevilacqua, Jun He, Cynthia Lander, Cam Patterson, Monte Willis
The cell-permeant peptide inhibitor of MAPKAP kinase 2 (MK2), MMI-0100, inhibits MK2 and downstream fibrosis and inflammation. Recent studies have demonstrated that MMI-0100 reduces intimal hyperplasia in a mouse vein graft model, pulmonary fibrosis in a murine bleomycin-induced model and development of adhesions in conjunction with abdominal surgery. MK2 is critical to the pathogenesis of ischemic heart injury as MK2(-/-) mice are resistant to ischemic remodeling. Therefore, we tested the hypothesis that inhibiting MK2 with MMI-0100 would protect the heart after acute myocardial infarction (AMI) in vivo...
December 2014: Journal of Molecular and Cellular Cardiology
Dayi Zhang, James P Berry, Di Zhu, Yun Wang, Yin Chen, Bo Jiang, Shi Huang, Harry Langford, Guanghe Li, Paul A Davison, Jian Xu, Eric Aries, Wei E Huang
Although uncultured microorganisms have important roles in ecosystems, their ecophysiology in situ remains elusive owing to the difficulty of obtaining live cells from their natural habitats. In this study, we employed a novel magnetic nanoparticle-mediated isolation (MMI) method to recover metabolically active cells of a group of previously uncultured phenol degraders, Burkholderiales spp., from coking plant wastewater biosludge; five other culturable phenol degraders-Rhodococcus sp., Chryseobacterium sp. and three different Pseudomonas spp...
March 2015: ISME Journal
Roberta Imperatore, Gianfranco Carotenuto, Maria Antonietta Di Grazia, Ida Ferrandino, Letizia Palomba, Raffaella Mariotti, Emilia Vitale, Sergio De Nicola, Angela Longo, Luigia Cristino
Gold nanoparticles are increasingly being employed in innovative biological applications thanks to their advantages of material- and size-dependent physics and chemical interactions with the cellular systems. On the other hand, growing concern has emerged on the toxicity which would render gold-based nanoparticles harmful to cell cultures, animals, and humans. Emerging attention is focused on the interaction of gold nanoparticles with nervous system, especially regarding the ability to overcome the blood-brain barrier (BBB) which represents the major impediment to the delivery of therapeutics into the brain...
April 2015: Journal of Biomedical Materials Research. Part A
Dan-Ni Wang, He Wang
OBJECTIVE: To improve the sample collection methods and bacteriologic localization patterns in male genital tract infection, and to investigate the influence of specimen collection and pathogen isolation on the diagnosis and treatment of prostatitis. METHODS: We collected the samples of the initial urinary stream, the third portion of the urinary stream, expressed prostatic secretion (ESP), and semen from 200 adult males with chronic prostatitis-like symptoms, inoculated them quantitatively in culture media for isolation of microorganisms, and evaluated their laboratory diagnostic significance according to the count of colonies and distribution of the isolates...
May 2014: Zhonghua Nan Ke Xue, National Journal of Andrology
Ashraf Ahmed, Khalil Ibrahim Qayed, Mahera Abdulrahman, Walter Tavares, Jack Rosenfeld
INTRODUCTION: Numerous studies have shown that multiple mini-interviews (MMI) provides a standard, fair, and more reliable method for assessing applicants. This article presents the first MMI experience for selection of medical residents in the Middle East culture and an Arab country. METHODS: In 2012, we started using the MMI in interviewing applicants to the residency program of Dubai Health Authority. This interview process consisted of eight, eight-minute structured interview scenarios...
August 2014: Medical Teacher
Maude Campagna-Vaillancourt, John Manoukian, Saleem Razack, Lily H P Nguyen
OBJECTIVES/HYPOTHESIS: To evaluate the acceptability and reliability of the Multiple Mini Interview (MMI) for the selection of applicants to an Otolaryngology-Head and Neck (OTL-HNS) residency program. STUDY DESIGN: Prospective observational study. METHODS: Canadian medical graduates applying to the OTL-HNS residency program at McGill University in 2011 and 2012 underwent a 7-station MMI. Upon completion, the major stakeholders commented on and rated various aspects of the MMI using a 7-point Likert scale...
January 2014: Laryngoscope
Allan Pau, Kamalan Jeevaratnam, Yu Sui Chen, Abdoul Aziz Fall, Charmaine Khoo, Vishna Devi Nadarajah
BACKGROUND: The Multiple Mini-Interview (MMI) has been used increasingly for selection of students to health professions programmes. OBJECTIVES: This paper reports on the evidence base for the feasibility, acceptability, reliability and validity of the MMI. DATA SOURCES: CINAHL and MEDLINE STUDY ELIGIBILITY CRITERIA: All studies testing the MMI on applicants to health professions training. STUDY APPRAISAL AND SYNTHESIS METHODS: Each paper was appraised by two reviewers...
December 2013: Medical Teacher
Yuta Komoike, Masato Matsuoka, Kenjiro Kosaki
While methimazole (MMI) is widely used in the therapy for hyperthyroidism, several groups have reported that maternal exposure to MMI results in a variety of congenital anomalies, including choanal and esophageal atresia, iridic and retinal coloboma, and delayed neurodevelopment. Thus, adverse effects of maternal exposure to MMI on fetal development have long been suggested; however, direct evidence for the teratogenicity of MMI has not been presented. Therefore, we studied the effects of MMI on early development by using zebrafish as a model organism...
June 2013: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
Yelena Golubeva, Rosalba Salcedo, Claudius Mueller, Lance A Liotta, Virginia Espina
Laser capture microdissection (LCM) allows the precise procurement of enriched cell populations from a heterogeneous tissue, or live cell culture, under direct microscopic visualization. Histologically enriched cell populations can be procured by harvesting cells of interest directly or isolating specific cells by ablating unwanted cells. The basic components of laser microdissection technology are (a) visualization of cells via light microscopy, (b) transfer of laser energy to a thermolabile polymer with either the formation of a polymer-cell composite (capture method) or transfer of laser energy via an ultraviolet laser to photovolatize a region of tissue (cutting method), and (c) removal of cells of interest from the heterogeneous tissue section...
2013: Methods in Molecular Biology
Harold I Reiter, Jocelyn Lockyer, Barry Ziola, Carol-Ann Courneya, Kevin Eva
PURPOSE: Traditional medical school admissions assessment tools may be limiting diversity. This study investigates whether the Multiple Mini-Interview (MMI) is diversity-neutral and, if so, whether applying it with greater weight would dilute the anticipated negative impact of diversity-limiting admissions measures. METHOD: Interviewed applicants to six medical schools in 2008 and 2009 underwent MMI. Predictor variables of MMI scores, grade point average (GPA), and Medical College Admission Test (MCAT) scores were correlated with diversity measures of age, gender, size of community of origin, income level, and self-declared aboriginal status...
April 2012: Academic Medicine: Journal of the Association of American Medical Colleges
Alison E M Vickers, Jason Heale, John R Sinclair, Stephen Morris, Josh M Rowe, Robyn L Fisher
Drug induced thyroid effects were evaluated in organotypic models utilizing either a rat thyroid lobe or human thyroid slices to compare rodent and human response. An inhibition of thyroid peroxidase (TPO) function led to a perturbation in the expression of key genes in thyroid hormone synthesis and release pathways. The clinically used thiourea drugs, methimazole (MMI) and 6-n-propyl-2-thioruacil (PTU), were used to evaluate thyroid drug response in these models. Inhibition of TPO occurred early as shown in rat thyroid lobes (2 h) and was sustained in both rat (24-48 h) and human (24 h) with ≥ 10 μM MMI...
April 1, 2012: Toxicology and Applied Pharmacology
Zhu-Hua Luo, Ka-Lai Pang, Yi-Rui Wu, Ji-Dong Gu, Raymond K K Chow, L L P Vrijmoed
Phthalate esters (PAEs) are important industrial compounds mainly used as plasticizers to increase flexibility and softness of plastic products. PAEs are of major concern because of their widespread use, ubiquity in the environment, and endocrine-disrupting toxicity. In this study, two fungal strains, Fusarium sp. DMT-5-3 and Trichosporon sp. DMI-5-1 which had the capability to degrade dimethyl phthalate esters (DMPEs), were isolated from mangrove sediments in the Futian Nature Reserve of Shenzhen, China, by enrichment culture technique...
2012: Progress in Molecular and Subcellular Biology
Akihito Muto, Alyssa Panitch, Namho Kim, Kinam Park, Padmini Komalavilas, Colleen M Brophy, Alan Dardik
Vein graft intimal hyperplasia remains the leading cause of graft failure, despite many pharmacological approaches that have failed to translate to human therapy. We investigated whether local suppression of inflammation and fibrosis with MMI-0100, a novel peptide inhibitor of Mitogen Activated Protein Kinase Activated Protein Kinase II (MK2), would be an alternative strategy to reduce cell proliferation and intimal hyperplasia. The cell permeant peptide MMI-0100 was synthesized using standard Fmoc chemistry...
January 2012: Vascular Pharmacology
Brian C Ward, Sandra Kavalukas, Jamie Brugnano, Adrian Barbul, Alyssa Panitch
BACKGROUND: Abdominal adhesions are a common side effect of surgical procedures with complications including infertility, chronic pain, and bowel obstruction, which may lead to the need for surgical lyses of the adhesions. Mitogen-activated protein kinase-activated protein kinase 2 (MK2) has been implicated in several diseases, involving inflammation and fibrosis. Thus, the development of a cell-penetrating peptide (CPP) that modulates MK2 activity may confer therapeutic benefit after abdominal surgery in general and more specifically after bowel anastomosis...
July 2011: Journal of Surgical Research
Huibin Huang, Yaxiong Shi, Ling Lin, Xisheng Li, Liangyi Li, Xiahong Lin, Dongming Xu
The mechanisms by which thyroid stimulating hormone (TSH) regulates the expression and activity of sodium iodide symporter (NIS) through cAMP-PKA have been partially elucidated by many studies. However, the effects of the TSH-mediated PLC-IP3 signaling pathway on the expression of NIS and how intracellular iodinated compounds interfere with these signaling pathways are poorly understood. In this study, we investigated the effects of the TSH-mediated cAMP-PKA and PLC-IP3 pathways on the expression of NIS in the presence of various intracellular iodinated compounds...
January 2011: Molecular Medicine Reports
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