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https://www.readbyqxmd.com/read/29036916/recent-progresses-and-development-of-advanced-atomic-layer-deposition-towards-high-performance-li-ion-batteries
#1
REVIEW
Wei Lu, Longwei Liang, Xuan Sun, Xiaofei Sun, Chen Wu, Linrui Hou, Jinfeng Sun, Changzhou Yuan
Electrode materials and electrolytes play a vital role in device-level performance of rechargeable Li-ion batteries (LIBs). However, electrode structure/component degeneration and electrode-electrolyte sur-/interface evolution are identified as the most crucial obstacles in practical applications. Thanks to its congenital advantages, atomic layer deposition (ALD) methodology has attracted enormous attention in advanced LIBs. This review mainly focuses upon the up-to-date progress and development of the ALD in high-performance LIBs...
October 14, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29036903/resveratrol-and-amyloid-beta-mechanistic-insights
#2
REVIEW
Yongming Jia, Na Wang, Xuewei Liu
The amyloid-beta (Aβ) hypothesis that dyshomeostasis between Aβ production and clearance is a very early, key molecular factor in the etiology of Alzheimer's disease (AD) has been proposed and examined in the AD research field. Scientists have focused on seeking natural products or drugs to influence the dynamic equilibrium of Aβ, targeting production and clearance of Aβ. There is emerging evidence that resveratrol (Res), a naturally occurring polyphenol mainly found in grapes and red wine, acts on AD in numerous in vivo and in vitro models...
October 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29036871/monitoring-of-need-for-recovery-and-prolonged-fatigue-within-the-working-population-evaluation-of-reliability-and-agreement-over-time
#3
H Hoofs, N W H Jansen, M W J Jansen, I J Kant
BACKGROUND: Need for recovery (NFR) and prolonged fatigue are two important concepts for monitoring short- and long-term outcomes of psychological job demands within employees. For effective monitoring it is, however, important to gain insight in the reproducibility of the instruments that are usedOBJECTIVE:The objective was to assess reproducibility of the NFR scale and Checklist Individual Strength (CIS), measuring NFR and prolonged fatigue respectively, in the working population. METHODS: Longitudinal data from the Maastricht Cohort Study (MCS) study was used, capturing 12,140 employees from 45 different companies at baseline...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036709/deep-learning-of-the-splicing-epi-genetic-code-reveals-a-novel-candidate-mechanism-linking-histone-modifications-to-esc-fate-decision
#4
Yungang Xu, Yongcui Wang, Jiesi Luo, Weiling Zhao, Xiaobo Zhou
Alternative splicing (AS) is a genetically and epigenetically regulated pre-mRNA processing to increase transcriptome and proteome diversity. Comprehensively decoding these regulatory mechanisms holds promise in getting deeper insights into a variety of biological contexts involving in AS, such as development and diseases. We assembled splicing (epi)genetic code, DeepCode, for human embryonic stem cell (hESC) differentiation by integrating heterogeneous features of genomic sequences, 16 histone modifications with a multi-label deep neural network...
September 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036672/convergence-and-divergence-of-brain-network-dysfunction-in-deficit-and-non-deficit-schizophrenia
#5
Miao Yu, Zhengjia Dai, Xiaowei Tang, Xiang Wang, Xiaobin Zhang, Weiwei Sha, Shuqiao Yao, Ni Shu, Xindi Wang, Jiaying Yang, Xiangyang Zhang, Xiangrong Zhang, Yong He, Zhijun Zhang
Deficit schizophrenia (DS), characterized by primary and enduring negative symptoms, has been considered as a pathophysiologically distinct schizophrenic subgroup. Neuroimaging characteristics of DS, especially functional brain network architecture, remain largely unknown. Resting-state functional magnetic resonance imaging and graph theory approaches were employed to investigate the topological organization of whole-brain functional networks of 114 male participants including 33 DS, 41 non-deficit schizophrenia (NDS) and 40 healthy controls (HCs)...
July 20, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036671/crispr-cas9-mediated-gene-knockout-is-insensitive-to-target-copy-number-but-is-dependent-on-guide-rna-potency-and-cas9-sgrna-threshold-expression-level
#6
Garmen Yuen, Fehad J Khan, Shaojian Gao, Jayne M Stommel, Eric Batchelor, Xiaolin Wu, Ji Luo
CRISPR/Cas9 is a powerful gene editing tool for gene knockout studies and functional genomic screens. Successful implementation of CRISPR often requires Cas9 to elicit efficient target knockout in a population of cells. In this study, we investigated the role of several key factors, including variation in target copy number, inherent potency of sgRNA guides, and expression level of Cas9 and sgRNA, in determining CRISPR knockout efficiency. Using isogenic, clonal cell lines with variable copy numbers of an EGFP transgene, we discovered that CRISPR knockout is relatively insensitive to target copy number, but is highly dependent on the potency of the sgRNA guide sequence...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036669/comparative-genome-and-transcriptome-analyses-reveal-adaptations-to-opportunistic-infections-in-woody-plant-degrading-pathogens-of-botryosphaeriaceae
#7
Ji Ye Yan, Wen Sheng Zhao, Zhen Chen, Qi Kai Xing, Wei Zhang, K W Thilini Chethana, Min Feng Xue, Jian Ping Xu, Alan J L Phillips, Yong Wang, Jian Hua Liu, Mei Liu, Ying Zhou, Ruvishika S Jayawardena, Ishara S Manawasinghe, Jin Bao Huang, Guang Hang Qiao, Chun Yuan Fu, Fei Fei Guo, Asha J Dissanayake, You Liang Peng, Kevin D Hyde, Xing Hong Li
Botryosphaeriaceae are an important fungal family that cause woody plant diseases worldwide. Recent studies have established a correlation between environmental factors and disease expression; however, less is known about factors that trigger these diseases. The current study reports on the 43.3 Mb de novo genome of Lasiodiplodia theobromae and five other genomes of Botryosphaeriaceae pathogens. Botryosphaeriaceous genomes showed an expansion of gene families associated with cell wall degradation, nutrient uptake, secondary metabolism and membrane transport, which contribute to adaptations for wood degradation...
October 3, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/29036608/insights-into-rna-polymerase-catalysis-and-adaptive-evolution-gained-from-mutational-analysis-of-a-locus-conferring-rifampicin-resistance
#8
Olga Yurieva, Vadim Nikiforov, Vadim Nikiforov, Michael O'Donnell, Arkady Mustaev
S531 of Escherichia coli RNA polymerase (RNAP) β subunit is a part of RNA binding domain in transcription complex. While highly conserved, S531 is not involved in interactions within the transcription complex as suggested by X-ray analysis. To understand the basis for S531 conservation we performed systematic mutagenesis of this residue. We find that the most of the mutations significantly decreased initiation-to-elongation transition by RNAP. Surprisingly, some changes enhanced the production of full-size transcripts by suppressing abortive loss of short RNAs...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036606/socioeconomic-status-and-childhood-cancer-incidence-a-population-based-multilevel-analysis
#9
Rebecca D Kehm, Logan G Spector, Jenny N Poynter, David M Vock, Theresa L Osypuk
The etiology of childhood cancers remains largely unknown, especially regarding environmental and behavioral risk factors. Unpacking the association between socioeconomic status (SES) and incidence may offer insight into such etiology. We tested associations between SES and childhood cancer incidence in a population-based case-cohort study (source cohort: Minnesota birth registry, 1989-2014). Cases, 0-14 years, were linked from the Minnesota Cancer Surveillance System to birth records through probabilistic record linkage...
September 27, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29036590/tissgdb-tissue-specific-gene-database-in-cancer
#10
Pora Kim, Aekyung Park, Guangchun Han, Hua Sun, Peilin Jia, Zhongming Zhao
Tissue-specific gene expression is critical in understanding biological processes, physiological conditions, and disease. The identification and appropriate use of tissue-specific genes (TissGenes) will provide important insights into disease mechanisms and organ-specific therapeutic targets. To better understand the tissue-specific features for each cancer type and to advance the discovery of clinically relevant genes or mutations, we built TissGDB (Tissue specific Gene DataBase in cancer) available at http://zhaobioinfo...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036488/morphological-physiological-and-ultrastructural-changes-in-flower-explain-the-spatio-temporal-emission-of-scent-volatiles-in-polianthes-tuberosa-l
#11
Saborni Maiti, Adinpunya Mitra
Tuberose or Polianthes tuberosa L. is a horticultural crop of tropical origin, widely cultivated for its adorable and intense floral fragrance in the evening. Here an investigation was made on the physiological and cell biological aspects of floral scent biosynthesis, tissue localization and emission that have not previously been examined. Volatiles collected from floral headspace were analysed through GC-MS for identification of individual compounds and elucidation of emission patterns. Transcripts accumulation and the amount of active enzyme were measured to understand the enzymatic route of scent volatiles biosynthesis...
September 22, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29036466/insights-into-epigenome-evolution-from-animal-and-plant-methylomes
#12
Soojin V Yi
Evolutionary studies of DNA methylation begin to provide insights into the underlying forces governing the variation of genomic DNA methylation across different species. Comparisons of gross levels of DNA methylation between distantly related species indicate that the size of the genome and the level of genomic DNA methylation are positively correlated. In plant genomes, this can be reliably explained by the contents of repetitive sequences, while the underlying driver of this correlation is less clear in animal genomes...
September 25, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29036463/multiple-links-between-shade-avoidance-and-auxin-networks
#13
María José Iglesias, Romina Sellaro, Matias D Zurbriggen, Jorge José Casal
Auxin has emerged as a key player in the adjustment of plant morphology to the challenge imposed by variable environmental conditions. Shade-avoidance responses, including the promotion of stem and petiole growth, leaf hyponasty, and the inhibition of branching, involve an intimate connection between light and auxin signalling. Low activity of photo-sensory receptors caused by the presence of neighbouring vegetation enhances the activity of PHYTOCHROME INTERACTING FACTORs (PIFs), which directly promote the expression of genes involved in auxin biosynthesis, conjugation, transport, perception, and signalling...
September 27, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29036450/crosstalk-between-nitric-oxide-and-mpk1-2-mediates-cold-acclimation-induced-chilling-tolerance-in-tomato
#14
Xiangzhang Lv, Shibei Ge, Golam Jalal Ahammed, Xun Xiang, Zhixin Guo, Jingquan Yu, Yanhong Zhou
The participation of nitric oxide (NO) in the responses of plants towards biotic and abiotic stresses is well established. However, the mechanism involved particularly in cold acclimation-induced chilling tolerance remains elusive. Here we show the cold acclimation induced-chilling tolerance was associated with inductions of nitrate reductase (NR)-dependent NO production, S<iS-nitrosylated glutathione reductase (GSNOR) activity and mitogen-activated protein kinases MPK1/2 activation in tomato plants. Silencing of NR<NRi resulted in decreased GSNOR activity and MPK1/2 activation, which subsequently compromised cold acclimation-induced chilling tolerance...
September 22, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29036433/left-ventricular-hypertrophy-predicts-cardiovascular-events-in-hypertensive-patients-with-coronary-artery-calcifications
#15
Chagai Grossman, Michael Levin, Nira Koren-Morag, Gill Bornstein, Avshalom Leibowitz, Ilan Ben-Zvi, Joseph Shemesh, Ehud Grossman
Background: Coronary artery calcification (CAC) is associated with increased cardiovascular (CV) risk. Left ventricular hypertrophy (LVH) is an independent risk factor for CV events. Our aim was to estimate the relative CV risk of LVH in the presence of CAC. Methods: We included asymptomatic hypertensive patients who were enrolled in the calcification arm of the INSIGHT (International Nifedipine Study Intervention as Goal for Hypertension Therapy). Patients had baseline echocardiography and computed tomography (CT) to assess CAC...
October 5, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29036417/coprophagous-insects-and-the-ecology-of-infectious-diseases-of-wildlife
#16
Elizabeth Nichols, Viviana Alarcón, Shaun Forgie, Luis A Gomez-Puerta, Matthew S Jones
A diversity of macro- and microparasitic species exert strong influences on wildlife population density, community structure, and ecosystem functioning, all through their impacts on individual host fitness. Through consuming, manipulating, and relocating wildlife feces, over 7,000 species of coprophagous dung beetles interact with a staggering diversity of wildlife parasites with fecal-oral transmission in ways that both increase and decrease transmission. Here, we review the mechanisms by which dung beetles influence micro- and macroparasite transmission and outline a future research framework that integrates theory and empirical insights to advance our understanding of how these relationships may interact with ongoing environmental change drivers to further influence wildlife populations and community structure...
September 28, 2017: ILAR Journal
https://www.readbyqxmd.com/read/29036381/project-echo-telementoring-intervention-for-managing-chronic-pain-in-primary-care-insights-from-a-qualitative-study
#17
Leslie Carlin, Jane Zhao, Ruth Dubin, Paul Taenzer, Hannah Sidrak, Andrea Furlan
Objective: Family physicians in Canada receive little training in chronic pain management; concomitantly, they face increasing pressure to reduce their prescribing of opioids. Project ECHO Ontario Chronic Pain/Opioid Stewardship (ECHO) is a telementoring intervention for primary care practitioners that enhances their pain management skills. This qualitative study reports participants' experiences and assessment of ECHO. Design: An opportunistic sample of multidisciplinary primary care providers attending one of three residential weekend workshops participated in focus group discussions...
September 27, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036354/plncpro-for-prediction-of-long-non-coding-rnas-lncrnas-in-plants-and-its-application-for-discovery-of-abiotic-stress-responsive-lncrnas-in-rice-and-chickpea
#18
Urminder Singh, Niraj Khemka, Mohan Singh Rajkumar, Rohini Garg, Mukesh Jain
Long non-coding RNAs (lncRNAs) make up a significant portion of non-coding RNAs and are involved in a variety of biological processes. Accurate identification/annotation of lncRNAs is the primary step for gaining deeper insights into their functions. In this study, we report a novel tool, PLncPRO, for prediction of lncRNAs in plants using transcriptome data. PLncPRO is based on machine learning and uses random forest algorithm to classify coding and long non-coding transcripts. PLncPRO has better prediction accuracy as compared to other existing tools and is particularly well-suited for plants...
October 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036353/structural-insights-into-rna-unwinding-and-degradation-by-rnase-r
#19
Lee-Ya Chu, Tung-Ju Hsieh, Bagher Golzarroshan, Yi-Ping Chen, Sashank Agrawal, Hanna S Yuan
RNase R is a conserved exoribonuclease in the RNase II family that primarily participates in RNA decay in all kingdoms of life. RNase R degrades duplex RNA with a 3' overhang, suggesting that it has RNA unwinding activity in addition to its 3'-to-5' exoribonuclease activity. However, how RNase R coordinates RNA binding with unwinding to degrade RNA remains elusive. Here, we report the crystal structure of a truncated form of Escherichia coli RNase R (residues 87-725) at a resolution of 1.85 Å. Structural comparisons with other RNase II family proteins reveal two open RNA-binding channels in RNase R and suggest a tri-helix 'wedge' region in the RNB domain that may induce RNA unwinding...
October 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036319/discovery-of-susceptibility-loci-associated-with-tuberculosis-in-han-chinese
#20
Hui Qi, Yong-Biao Zhang, Lin Sun, Cheng Chen, Biao Xu, Fang Xu, Jia-Wen Liu, Jin-Cheng Liu, Chen Chen, Wei-Wei Jiao, Chen Shen, Jing Xiao, Jie-Qiong Li, Ya-Jie Guo, Yong-Hong Wang, Qin-Jing Li, Qing-Qin Yin, Ying-Jia Li, Ting Wang, Xing-Yun Wang, Ming-Liang Gu, Jun Yu, A-Dong Shen
Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of genetic factors in tuberculosis (TB) susceptibility. Despite having the third highest global TB burden, no TB-related GWAS has been performed in China. Here, we performed the first three-stage GWAS on TB in the Han Chinese population. In the stage 1 (discovery stage), after quality control, 691,388 SNPs present in 972 TB patients and 1,537 controls were retained. After replication on an additional 3,460 TB patients and 4,862 controls (stages 2 and 3), we identified three significant loci associated with TB, the most significant of which was rs4240897 (logistic regression P = 1...
September 26, 2017: Human Molecular Genetics
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