keyword
https://read.qxmd.com/read/35814366/ahcc-%C3%A2-supplementation-to-support-immune-function-to-clear-persistent-human-papillomavirus-infections
#21
JOURNAL ARTICLE
Judith A Smith, Anjali A Gaikwad, Lata Mathew, Barbara Rech, Jonathan P Faro, Joseph A Lucci, Yu Bai, Randall J Olsen, Teresa T Byrd
OBJECTIVE: To determine the efficacy, safety, and durability of the use of AHCC supplementation for 6 months to support the host immune system to clear high-risk human papillomavirus (HPV) infections. The AHCC supplement is a proprietary, standardized extract of cultured lentinula edodes mycelia (AHCC® , Amino Up, Ltd., Sapporo, Japan) that has been shown to have unique immune modulatory benefits. STUDY DESIGN: This was a randomized, double-blind, placebo-controlled study (CTN: NCT02405533) in 50 women over 30 years of age with confirmed persistent high-risk HPV infections for greater than 2 years...
2022: Frontiers in Oncology
https://read.qxmd.com/read/35812247/nav3-is-a-novel-prognostic-biomarker-affecting-the-immune-status-of-the-tumor-microenvironment-in-colorectal-cancer
#22
JOURNAL ARTICLE
Menglong Li, Zhiqiang Wang, Shuai Dong, Yang Xu
Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Tumor microenvironment (TME) plays a crucial role in the development of CRC. With the deep understanding of TME function, growing studies have demonstrated that alteration in tumor-infiltrating immune cells (TICs) and gene expressions are associated with clinical outcomes of various tumors. In this study, we aimed to recognize critical prognostic genes involved in immune states in TME of CRC. Hence, the proportion of TICs and the number of immune and stromal components in CRC samples from TCGA datasets were calculated by the use of CIBERSORT and ESTIMATE calculation methods...
2022: Journal of Immunology Research
https://read.qxmd.com/read/35632488/immunological-aspects-of-human-papilloma-virus-related-cancers-always-says-i-am-like-a-box-of-complexity-you-never-know-what-you-are-gonna-get
#23
REVIEW
Ehsan Soleymaninejadian, Paola Zelini, Irene Cassaniti, Fausto Baldanti, Mattia Dominoni, Andrea Gritti, Barbara Gardella
The human papillomavirus (HPV) can cause different cancers in both men and women. The virus interferes with functions of the cervix, vulva, vagina, anus in the anogenital area, breast, and head and neck cancer due to the local lesions. The tumors lead to death if not treated as a result of distant metastasis to internal organs and brain. Moreover, HPV attenuates the immune system during chronic infection and releases viral antigens into the tumor microenvironment. The tumors know how difficult is to win the battle with a strong united army of immune cells that are equipped with cytokines and enzymes...
May 6, 2022: Vaccines
https://read.qxmd.com/read/35593263/killer-cell-immunoglobulin-like-receptor-kir-gene-contents-are-they-associated-with-cervical-cancer
#24
JOURNAL ARTICLE
Alok K Tembhurne, Amita Maheshwari, Himangi Warke, Hemangi Chaudhari, Shilpa C Kerkar, Kedar Deodhar, Bharat Rekhi, Jayanti Mania-Pramanik
Killer cell immunoglobulin-like receptors (KIRs) are required for natural killer cell function against virus-infected cells or tumor cells. KIR gene content polymorphisms in Indian women with cervical cancer (CaCx) remain unexplored. Hence, we analyzed the frequencies of KIR genes, KIR haplotypes, and Bx subsets to draw their association with CaCx. The polymerase chain reaction-sequence-specific primer method was used for KIR genotyping in three groups of women: healthy controls (n = 114), women with human papillomavirus (HPV) infection (n = 70), and women with CaCx (n = 120)...
May 20, 2022: Journal of Medical Virology
https://read.qxmd.com/read/35413989/increased-expression-of-tigit-and-klrg1-correlates-with-impaired-cd56-bright-nk-cell-immunity-in-hpv16-related-cervical-intraepithelial-neoplasia
#25
JOURNAL ARTICLE
You Nie, Dandan Liu, Wen Yang, Yazhuo Li, Lihua Zhang, Xia Cheng, Ruyu Chen, Bingbing Yuan, Guangzheng Zhang, Hongwei Wang
BACKGROUND: The onset and progression of cervical intraepithelial neoplasia (CIN) are closely associated with the persistent infection of high-risk HPV (especially type16), which is mainly caused by immune escape. Natural killer (NK) cells play an important role against virally infected cells and tumor cells through a fine balance of signals from multiple surface receptors. Overexpression of non-MHC-I specific inhibitory receptors TIGIT, KLRG1, Siglec-7, LAIR-1, and CD300a on NK cells correlates with cellular exhaustion and immune evasion, but these receptors have not been investigated in CIN...
April 12, 2022: Virology Journal
https://read.qxmd.com/read/35314434/harnessing-radiotherapy-induced-nk-cell-activity-by-combining-dna-damage-response-inhibition-and-immune-checkpoint-blockade
#26
JOURNAL ARTICLE
Emmanuel C Patin, Magnus T Dillon, Pablo Nenclares, Lorna Grove, Heba Soliman, Isla Leslie, Davina Northcote, Galabina Bozhanova, Eva Crespo-Rodriguez, Holly Baldock, Harriet Whittock, Gabriella Baker, Joan Kyula, Jeane Guevara, Alan A Melcher, James Harper, Hormas Ghadially, Simon Smith, Malin Pedersen, Martin McLaughlin, Kevin J Harrington
BACKGROUND: Despite therapeutic gains from immune checkpoint inhibitors (ICI) in many tumor types, new strategies are needed to extend treatment benefits, especially in patients failing to mount effective antitumor T-cell responses. Radiation and drug therapies can profoundly affect the tumor immune microenvironment. Here, we aimed to identify immunotherapies to increase the antitumor response conferred by combined ataxia telangiectasia and Rad3-related kinase inhibition and radiotherapy...
March 2022: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/34889385/how-immunodeficiency-can-lead-to-malignancy
#27
JOURNAL ARTICLE
Sung-Yun Pai, Kathryn Lurain, Robert Yarchoan
Immunodeficiency, whether acquired in the case of human immunodeficiency virus (HIV) infection or congenital due to inborn errors of immunity (IEIs), presents clinically with not only infection and immune dysregulation but also increased risk of malignancy. The range of malignancies seen is relatively limited and attributable to the particular cellular and molecular defects in each disease. CD4+ T-cell lymphopenia in people living with HIV infection (PLWH) and certain IEIs drive the predisposition to aggressive B-cell non-Hodgkin lymphomas, including certain rare subtypes rarely seen in immunocompetent individuals...
December 10, 2021: Hematology—the Education Program of the American Society of Hematology
https://read.qxmd.com/read/34831327/nk-cell-regulation-in-cervical-cancer-and-strategies-for-immunotherapy
#28
REVIEW
Adriana Gutiérrez-Hoya, Isabel Soto-Cruz
Cervical cancer is one of the most prevalent gynaecological malignancies worldwide and is related to human papillomavirus (HPV) infection, viral persistence, progression, and invasion. Therefore, the immune response is linked to HPV status. Natural killer (NK) cells play a central role against virus-infected cells and tumours through a delicate balance between activating and inhibitory receptors and secretion of cytokines and chemokines. These cells also play a crucial role in tumour immunosurveillance. For these reasons, there is growing interest in harnessing NK cells as an immunotherapy for cervical cancer...
November 10, 2021: Cells
https://read.qxmd.com/read/34469647/treatment-of-relapsing-hpv-diseases-by-restored-function-of-natural-killer-cells
#29
JOURNAL ARTICLE
Andrea Lisco, Amy P Hsu, Dimana Dimitrova, Diana M Proctor, Emily M Mace, Peiying Ye, Megan V Anderson, Stephanie N Hicks, Christopher Grivas, Dima A Hammoud, Maura Manion, Gabriel J Starrett, Alvin Farrel, Kerry Dobbs, Isaac Brownell, Christopher Buck, Luigi D Notarangelo, Jordan S Orange, Warren J Leonard, Michael I Orestes, Anju T Peters, Jennifer A Kanakry, Julia A Segre, Heidi H Kong, Irini Sereti
Human papillomavirus (HPV) infections underlie a wide spectrum of both benign and malignant epithelial diseases. In this report, we describe the case of a young man who had encephalitis caused by herpes simplex virus during adolescence and currently presented with multiple recurrent skin and mucosal lesions caused by HPV. The patient was found to have a pathogenic germline mutation in the X-linked interleukin-2 receptor subunit gamma gene ( IL2RG ), which was somatically reverted in T cells but not in natural killer (NK) cells...
September 2, 2021: New England Journal of Medicine
https://read.qxmd.com/read/34295178/identification-and-validation-of-biglycan-as-prognosis-and-therapy-markers-for-patients-with-stomach-adenocarcinoma
#30
JOURNAL ARTICLE
Changming Shao, Chunfa Cheng, Qinshu Shao, Bing Chen
OBJECTIVE: Previous studies have confirmed the biglycan (BGN) as a core gene in stomach adenocarcinoma (STAD). Present study aimed at conducting further investigations to reveal the potential function of BGN in STAD. METHODS: The mRNA and protein expressions of BGN in STAD were firstly evaluated, followed by immune infiltration analyses. The influence of BGN expression on the overall survival of STAD patients was subsequently analyzed, and a restrict survival analysis was performed as well...
2021: International Journal of General Medicine
https://read.qxmd.com/read/34055652/repurposing-infectious-diseases-vaccines-against-cancer
#31
REVIEW
Liese Vandeborne, Pan Pantziarka, An M T Van Nuffel, Gauthier Bouche
Vaccines used to prevent infections have long been known to stimulate immune responses to cancer as illustrated by the approval of the Bacillus Calmette-Guérin (BCG) vaccine to treat bladder cancer since the 1970s. The recent approval of immunotherapies has rejuvenated this research area with reports of anti-tumor responses with existing infectious diseases vaccines used as such, either alone or in combination with immune checkpoint inhibitors. Here, we have reviewed and summarized research activities using approved vaccines to treat cancer...
2021: Frontiers in Oncology
https://read.qxmd.com/read/34051752/disseminated-nontuberculous-mycobacteriosis-and-fungemia-after-second-delivery-in-a-patient-with-monomac-syndrome-gata2-mutation-a-case-report
#32
JOURNAL ARTICLE
Mizuki Haraguchi, Norihiro Harada, Junko Watanabe, Hitomi Yoshikawa, Yukina Shirai, Moegi Komura, Mika Koyama, Jun Ito, Yutaka Tsukune, Yoshiya Horimoto, Takuo Hayashi, Tetsutaro Nagaoka, Toshimasa Uekusa, Kazuhisa Takahashi
BACKGROUND: Heterozygous mutations in the transcription factor GATA2 result in a wide spectrum of clinical phenotypes, including monocytopenia and Mycobacterium avium complex (MAC) infection (MonoMAC) syndrome. Patients with MonoMAC syndrome typically are infected by disseminated nontuberculous mycobacteria, fungi, and human papillomavirus, exhibit pulmonary alveolar proteinosis during late adolescence or early adulthood, and manifest with decreased content of dendritic cells (DCs), monocytes, and B and natural killer (NK) cells...
May 29, 2021: BMC Infectious Diseases
https://read.qxmd.com/read/34017381/profiles-of-immune-cell-infiltration-and-immune-related-genes-in-the-tumor-microenvironment-of-hnscc-with-or-without-hpv-infection
#33
JOURNAL ARTICLE
Dajie Zhou, Jing Wang, Junxin Wang, Xiangdong Liu
Head and neck squamous cell carcinoma (HNSCC) are the sixth most common cancer type in the world. Human papillomavirus (HPV) infection is an emerging risk factor for HNSCC. Immune infiltration of HNSCC is linked to therapeutic results. This article aimed to decide whether variations in HPV status affect immune infiltration, molecular mechanism, and how these results vary in HNSCC patients. We investigated the tumor-infiltrating immune cells (TIICs) and immune-related gene differences between HPV (+) and HPV (-) HNSCC...
2021: American Journal of Translational Research
https://read.qxmd.com/read/33965189/hematopoietic-cell-transplantation-and-outcomes-related-to-human-papillomavirus-disease-in-gata2-deficiency
#34
JOURNAL ARTICLE
Mark Parta, Kristen Cole, Daniele Avila, Lisa Duncan, Kristin Baird, Bazetta Blacklock Schuver, Jennifer Wilder, Cindy Palmer, Janine Daub, Amy P Hsu, Christa S Zerbe, Beatriz E Marciano, Jennifer M Cuellar-Rodriguez, Thomas R Bauer, Martha Nason, Katherine R Calvo, Melissa Merideth, Pamela Stratton, Alan DeCherney, Nirali N Shah, Steven M Holland, Dennis D Hickstein
GATA2 deficiency is a bone marrow failure syndrome effectively treated with hematopoietic cell transplantation (HCT), which also addresses the predisposition to many infections (prominently mycobacterial). However, many GATA2-deficient persons who come to HCT also have prevalent and refractory human papilloma virus disease (HPVD), which can be a precursor to cancer. We analyzed 75 HCT recipients for the presence of HPVD to identify patient characteristics and transplantation results that influence HPVD outcomes...
May 2021: Transplantation and cellular therapy
https://read.qxmd.com/read/33952700/immune-evasion-in-hpv-head-and-neck-precancer-cancer-transition-is-driven-by-an-aneuploid-switch-involving-chromosome-9p-loss
#35
JOURNAL ARTICLE
William N William, Xin Zhao, Joy J Bianchi, Heather Y Lin, Pan Cheng, J Jack Lee, Hannah Carter, Ludmil B Alexandrov, Jim P Abraham, David B Spetzler, Steven M Dubinett, Don W Cleveland, Webster Cavenee, Teresa Davoli, Scott M Lippman
An aneuploid-immune paradox encompasses somatic copy-number alterations (SCNAs), unleashing a cytotoxic response in experimental precancer systems, while conversely being associated with immune suppression and cytotoxic-cell depletion in human tumors, especially head and neck cancer (HNSC). We present evidence from patient samples and cell lines that alterations in chromosome dosage contribute to an immune hot-to-cold switch during human papillomavirus-negative (HPV- ) head and neck tumorigenesis. Overall SCNA (aneuploidy) level was associated with increased CD3+ and CD8+ T cell microenvironments in precancer (mostly CD3+ , linked to trisomy and aneuploidy), but with T cell-deficient tumors...
May 11, 2021: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/33813258/phototherapy-together-with-it-triggered-immunological-response-for-anti-hpv-treatment-of-oropharyngeal-cancer-removing-tumor-and-pathogenic-virus-simultaneously
#36
JOURNAL ARTICLE
Zhao Liu, Xinxin Yang, Ruiqi Liu, Junjie Bao, Na An, Shan Jiang, Susheng Miao, Chongshen Guo, Guofan Qu, Hongxue Meng
Oropharyngeal squamous cell carcinoma (OPSCC) is one of most common cancers that often brings lots of inconvenience to the patient in swallowing and phonation even after the operation. Moreover, OPSCC is typically as nodal metastases and high recurrence rate due to the high-risk human papillomavirus (HPV) infection for 90% of patients. Obviously, completely curing OPSCC requires simultaneous removal of solid tumor and related pathogenic virus, which is very indispensable but never be realized by any kind of clinical therapy up to now...
May 2021: Biomaterials
https://read.qxmd.com/read/33343946/verruca-vulgaris-and-seborrheic-keratosis-exacerbated-by-immunosuppression
#37
Shohei Iida, Kyoko Sugioka, Makoto Kondo, Yoshiaki Matsushima, Kento Mizutani, Koji Habe, Keiichi Yamanaka
Verruca vulgaris is an infectious disease caused by the human papillomavirus and characterized by hyperkeratotic papules or plaques with a clear boundary. Seborrheic keratosis is a commonly encountered lesion on the face, trunk, or extremities and is described as seborrheic verruca because of its clinical similarity to warts; furthermore, it is occasionally associated with immune suppression, especially in cases of Leser-trélat syndrome. Although these diseases are frequently found in healthy individuals, they typically show a good response to cryotherapy...
2020: Case Reports in Dermatological Medicine
https://read.qxmd.com/read/33255617/lectin-like-transcript-1-llt1-checkpoint-a-novel-independent-prognostic-factor-in-hpv-negative-oropharyngeal-squamous-cell-carcinoma
#38
JOURNAL ARTICLE
Mario Sanchez-Canteli, Francisco Hermida-Prado, Christian Sordo-Bahamonde, Irene Montoro-Jiménez, Esperanza Pozo-Agundo, Eva Allonca, Aitana Vallina-Álvarez, César Álvarez-Marcos, Segundo Gonzalez, Juana M García-Pedrero, Juan P Rodrigo
Lectin-like transcript 1 (LLT1) expression by tumor cells contributes to immune evasion, thereby emerging as a natural killer (NK) cell-mediated immunotherapeutic target. This study is the first to investigate LLT1 expression (encoded by CLEC2D gene) in head and neck cancers to ascertain its impact on patient prognosis. LLT1 expression was analyzed by immunohistochemistry in a homogeneous cohort of human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinomas (OPSCC), and correlated with clinical data...
November 25, 2020: Biomedicines
https://read.qxmd.com/read/32297993/an-immunogenomic-investigation-of-oral-cavity-squamous-cell-carcinoma-in-patients-aged-45-years-and-younger
#39
JOURNAL ARTICLE
Christopher A Maroun, Gangcai Zhu, Carole Fakhry, Christine G Gourin, Tanguy Y Seiwert, Peter S Vosler, Marietta Tan, Wayne Koch, David W Eisele, Drew M Pardoll, Rajarsi Mandal
OBJECTIVES/HYPOTHESIS: To investigate differences in the immunogenomic landscape among young patients presenting with oral cavity squamous cell carcinoma (OCSCC). STUDY DESIGN: Retrospective database review. METHODS: Normalized messenger mRNA expression data were downloaded from The Cancer Genome Atlas (TCGA) database. OCSCC patients were categorized into young and older age groups with a cutoff of 45 years. Human papillomavirus-positive tumors were excluded...
February 2021: Laryngoscope
https://read.qxmd.com/read/32051748/topical-application-of-temperature-sensitive-caerin-1-1-and-1-9-gel-inhibits-tc-1-tumor-growth-in-mice
#40
JOURNAL ARTICLE
Bowei Ma, Jianwei Yuan, Shu Chen, Kunsong Huang, Qianbo Wang, Jianchun Ma, Ruoting Lin, Lu Zhang, Yingying Zhou, Tianfang Wang, Shelley F Walton, Xuan Pan, Guoqiang Chen, Yuejian Wang, Guoying Ni, Xiaosong Liu
Genital warts, which are one of the most common sexually transmitted diseases (STDs), result from persistent infection with human papillomavirus (HPV), especially subtypes 6 or 11. Topical application of 5% imiquimod cream is currently recommended as a first-line treatment choice for genital warts, but the clearance and patient compliance rates remain less than sufficient. In the current study, we developed a temperature-sensitive gel that contains the host-defense peptides caerin 1.1 and 1.9, which were originally isolated from Australian tree frogs of the genus Litoria ...
2020: American Journal of Translational Research
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