keyword
https://read.qxmd.com/read/38471664/prevention-and-treatment-of-hpv-related-cancer-through-a-mrna-vaccine-expressing-apc-targeting-antigen
#1
JOURNAL ARTICLE
Xiaoxuan Li, Huiyan Wang, Wujiang Lai, Jinrong Liao, Wenyu Mo, Keke Huang, Liqing He, Xiaomei Liang, Zhibin Yu, Jiang Xu, Xianwu Hua, Fujun Hou, Jun Ding, William Wei-Guo Jia, Kuan Zhang, Yifeng Wang
Persistent human papillomavirus (HPV) infection is associated with multiple malignancies. Developing therapeutic vaccines to eliminate HPV-infected and malignant cells holds significant value. In this study, we introduced a lipid nanoparticle encapsulated mRNA vaccine expressing tHA-mE7-mE6. Mutations were introduced into E6 and E7 of HPV to eliminate their tumourigenicity. A truncated influenza haemagglutinin protein (tHA), which binds to the CD209 receptor on the surface of dendritic cells (DCs), was fused with mE7-mE6 in order to allow efficient uptake of antigen by antigen presenting cells...
March 12, 2024: Immunology
https://read.qxmd.com/read/38400189/immunity-from-nk-cell-subsets-is-important-for-vaccine-mediated-protection-in-hpv-cancers
#2
JOURNAL ARTICLE
Madison P O'Hara, Ananta V Yanamandra, K Jagannadha Sastry
High-risk human papillomaviruses (HPVs) are associated with genital and oral cancers, and the incidence of HPV+ head and neck squamous cell cancers is fast increasing in the USA and worldwide. Survival rates for patients with locally advanced disease are poor after standard-of-care chemoradiation treatment. Identifying the antitumor host immune mediators important for treatment response and designing strategies to promote them are essential. We reported earlier that in a syngeneic immunocompetent preclinical HPV tumor mouse model, intranasal immunization with an HPV peptide therapeutic vaccine containing the combination of aGalCer and CpG-ODN adjuvants (TVAC) promoted clearance of HPV vaginal tumors via induction of a strong cytotoxic T cell response...
February 17, 2024: Vaccines
https://read.qxmd.com/read/38271218/mediating-effect-of-white-blood-cells-and-tobacco-exposure-on-cervical-neoplasm-risk-among-taiwanese-women
#3
JOURNAL ARTICLE
Ya Wen Shih, Ching Wen Chang, Hui-Chen Rita Chang, Jia Ruey Tsai, Wei-Jun Wang, Hui Fen Fang, Chia Ling Lin, Yohanes Andy Rias, Hsiu Ting Tsai
Background: Both the high-risk human papillomavirus (HR-HPV) infection and tobacco exposure are significantly associated with cervical neoplasm risk. Immune cells play important roles in carcinogenesis. However, it is still unclear whether immune cells have a mediating effect on the HR-HPV infection and tobacco exposure with cervical neoplasm development. Aim: The aim of this study was to determine how the increased white blood cell (WBC) count affects the relationship between HR-HPV DNA load and tobacco exposure in the development of cervical neoplasia...
January 25, 2024: Biological Research for Nursing
https://read.qxmd.com/read/38090581/%C3%AE-%C3%AE-t-cell-mediated-cytotoxicity-against-patient-derived-healthy-and-cancer-cervical-organoids
#4
JOURNAL ARTICLE
Junxue Dong, David Holthaus, Christian Peters, Stefanie Koster, Marzieh Ehsani, Alvaro Quevedo-Olmos, Hilmar Berger, Michal Zarobkiewicz, Mandy Mangler, Rajendra Kumar Gurumurthy, Nina Hedemann, Cindrilla Chumduri, Dieter Kabelitz, Thomas F Meyer
Cervical cancer is a leading cause of death among women globally, primarily driven by high-risk papillomaviruses. However, the effectiveness of chemotherapy is limited, underscoring the potential of personalized immunotherapies. Patient-derived organoids, which possess cellular heterogeneity, proper epithelial architecture and functionality, and long-term propagation capabilities offer a promising platform for developing viable strategies. In addition to αβ T cells and natural killer (NK) cells, γδ T cells represent an immune cell population with significant therapeutic potential against both hematologic and solid tumours...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37550272/invasive-mucorales-sinusitis-in-a-young-patient-with-emberger-syndrome-and-newly-diagnosed-aml-a-case-report-and-literature-review-of-invasive-fungal-infections-in-gata2-deficiency
#5
REVIEW
Chia-Yu Chiu, Takahiro Matsuo, Sebastian Wurster, Yoheved Gerstein, Danielle E Hammond, Kelly S Chien, Courtney DiNardo, Dimitrios P Kontoyiannis
Germline pathogenic variants (PVs) in the gene encoding the GATA2 transcription factor can result in profound reductions of monocytes, dendritic cells, natural killer cells and B cells. GATA2 PVs are associated with an increased risk of myeloid malignancies and a predisposition to nontuberculous mycobacterial and human papillomavirus infections. Additionally, invasive fungal infections (IFIs) have been reported in individuals with GATA2 PVs, even in the absence of myeloid malignancies. In this report, we present the case of a 40-year-old man with Emberger syndrome (GATA2 mutation, recently diagnosed acute myeloid leukaemia [AML] and history of lymphedema with hearing loss) who developed Mucorales sinusitis while receiving his first course of remission induction chemotherapy...
August 7, 2023: Mycoses
https://read.qxmd.com/read/37459782/dual-anti-pd-l-1-tgf-%C3%AE-inhibitors-in-cancer-immunotherapy-updated
#6
REVIEW
Zana Karami, Keywan Mortezaee, Jamal Majidpoor
Immune checkpoint inhibitor (ICI) therapy suffers from tumor resistance and relapse in majority of patients due to the suppressive tumor immune microenvironment (TIME). Advances in the field have brought about development of fusion proteins able to target two signaling simultaneously and to exert maximal anti-cancer immunity. Bispecific inhibitors of transforming growth factor (TGF)-β signaling and programmed death-1 (PD-1) or programmed death-ligand 1 (PD-L1) are developed to reduce the rate of relapse and to achieve durable anti-cancer therapy...
July 15, 2023: International Immunopharmacology
https://read.qxmd.com/read/37392167/overexpression-of-cd73-is-associated-with-recurrence-and-poor-prognosis-of-gingivobuccal-oral-cancer-as-revealed-by-transcriptome-and-deep-immune-profiling-of-paired-tumor-and-margin-tissues
#7
JOURNAL ARTICLE
Ankita Chatterjee, Amrita Chaudhary, Arnab Ghosh, Pattatheyil Arun, Geetashree Mukherjee, Indu Arun, Arindam Maitra, Nidhan Biswas, Partha P Majumder
BACKGROUND: For various cancers, differences in response to treatment and subsequent survival period have been reported to be associated with variation in immune contextures. AIM: We sought to identify whether such association exists in respect of gingivobuccal oral cancer. MATERIALS AND METHODS: We performed deep immune profiling of tumor and margin tissues collected from 46 treatment naïve, Human Papillomavirus (HPV) negative, patients...
July 1, 2023: Cancer Medicine
https://read.qxmd.com/read/37356050/the-rig-i-agonist-m8-triggers-cell-death-and-natural-killer-cell-activation-in-human-papillomavirus-associated-cancer-and-potentiates-cisplatin-cytotoxicity
#8
JOURNAL ARTICLE
Carlo Girone, Federica Calati, Irene Lo Cigno, Valentina Salvi, Valentina Tassinari, Tiziana Schioppa, Cinzia Borgogna, Ludovica Lospinoso Severini, John Hiscott, Cristina Cerboni, Alessandra Soriani, Daniela Bosisio, Marisa Gariglio
Although the activation of innate immunity to treat a wide variety of cancers is gaining increasing attention, it has been poorly investigated in human papillomavirus (HPV)-associated malignancies. Because these tumors harbor a severely impaired cGAS-STING axis, but they still retain a largely functional RIG-I pathway, another critical mediator of adaptive and innate immune responses, we asked whether RIG-I activation by the 5'ppp-RNA RIG-I agonist M8 would represent a therapeutically viable option to treat HPV+ cancers...
June 25, 2023: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/37350788/development-of-virus-like-particles-with-inbuilt-immunostimulatory-properties-as-vaccine-candidates
#9
JOURNAL ARTICLE
Simon Collett, Linda Earnest, Julio Carrera Montoya, Melissa A Edeling, Ashley Yap, Chinn Yi Wong, Dale Christiansen, Jason Roberts, Jamie Mumford, Valerie Lecouturier, Vincent Pavot, Sergio Marco, Joon Keit Loi, Cameron Simmons, Shivali A Gulab, Jason M Mackenzie, Aaron Elbourne, Paul A Ramsland, Garth Cameron, Dhiraj Hans, Dale I Godfrey, Joseph Torresi
The development of virus-like particle (VLP) based vaccines for human papillomavirus, hepatitis B and hepatitis E viruses represented a breakthrough in vaccine development. However, for dengue and COVID-19, technical complications, such as an incomplete understanding of the requirements for protective immunity, but also limitations in processes to manufacture VLP vaccines for enveloped viruses to large scale, have hampered VLP vaccine development. Selecting the right adjuvant is also an important consideration to ensure that a VLP vaccine induces protective antibody and T cell responses...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/37287196/diverse-intratumoral-heterogeneity-and-immune-microenvironment-of-two-hpv-related-cervical-cancer-types-revealed-by-single-cell-rna-sequencing
#10
JOURNAL ARTICLE
Chunbo Li, Danyang Liu, Yu Zhao, Yan Ding, Keqin Hua
Cervical squamous cell carcinoma (SCC) and adenocarcinoma (AD) are the main histological types of human papillomavirus-related cervical cancer. However, there are few reports on cell type-specific molecular differences between SCC and AD. Here, we used unbiased droplet-based single-cell RNA sequencing to elucidate the cellular differences between SCC and AD in tumor heterogeneity, and tumor microenvironment (TME). A total of 61 723 cells from three SCC and three AD patients, were collected and divided into nine cell types...
June 2023: Journal of Medical Virology
https://read.qxmd.com/read/37247092/gata2-deficiency-predisposition-to-myeloid-malignancy-and-hematopoietic-cell-transplantation
#11
REVIEW
Roma V Rajput, Danielle E Arnold
PURPOSE OF REVIEW: GATA2 deficiency is a haploinsufficiency syndrome associated with a wide spectrum of disease, including severe monocytopenia and B and NK lymphopenia, predisposition to myeloid malignancies, human papillomavirus infections, and infections with opportunistic organisms, particularly nontuberculous mycobacteria, herpes virus, and certain fungi. GATA2 mutations have variable penetrance and expressivity with imperfect genotype-phenotype correlations. However, approximately 75% of patients will develop a myeloid neoplasm at some point...
May 29, 2023: Current Hematologic Malignancy Reports
https://read.qxmd.com/read/37217069/a-costimulatory-chimeric-antigen-receptor-targeting-trop2-enhances-the-cytotoxicity-of-nk-cells-expressing-a-t-cell-receptor-reactive-to-human-papillomavirus-type-16-e7
#12
JOURNAL ARTICLE
Isaac Quiros-Fernandez, Mansour Poorebrahim, Frederik Marmé, Stefan Eg Burdach, Angel Cid-Arregui
Immune cells modified to express a tumor-reactive T cell receptor (TCR) have shown limited efficacy as stand-alone therapy against solid tumors. Genital and oropharyngeal carcinomas induced by human papillomavirus (HPV) type 16 express constitutively its E6 and E7 oncoproteins, which makes them convenient targets for adoptive cell immunotherapy. However, viral antigen presentation by tumor cells is low and limits the anti-tumor efficacy of CD8+ T cells. To enhance the functionality of immune effector cells, we have devised a strategy combining a costimulatory chimeric antigen receptor (CAR) with a TCR...
May 20, 2023: Cancer Letters
https://read.qxmd.com/read/37127618/peripheral-blood-lymphocytes-influence-human-papillomavirus-infection-and-clearance-a-retrospective-cohort-study
#13
JOURNAL ARTICLE
Ye Li, Yebin Feng, Yanlin Chen, Wenyu Lin, Hangjing Gao, Ming Chen, Kelvin Stefan Osafo, Xiaodan Mao, Yafang Kang, Leyi Huang, Dabin Liu, Shuxia Xu, Lixiang Huang, Binhua Dong, Pengming Sun
BACKGROUND: There is a close correlation between HPV infection and systemic immune status. The purpose of this study was to determine which lymphocytes in peripheral blood influence human papillomavirus (HPV) infection and to identify whether peripheral blood lymphocyte (PBL) subsets could be used as biomarkers to predict HPV clearance in the short term. METHODS: This study involved 716 women undergoing colposcopy from 2019 to 2021. Logistic and Cox regression were used to analyze the association of PBLs with HPV infection and clearance...
May 1, 2023: Virology Journal
https://read.qxmd.com/read/36961058/seborrheic-keratosis-caused-by-human-papillomavirus-type-20-ameliorated-by-zinc-oxide-ointment
#14
JOURNAL ARTICLE
Makoto Kondo, Yoshiaki Matsushima, Takehisa Nakanishi, Shohei Iida, Koji Habe, Keiichi Yamanaka
A 91-year-old woman visited our department with scattered small nodule lesions and multiple pules or plaques with a stuck-on appearance. The lesions were intractable and resistant to several treatments. Immunodeficiency was excluded by examinations including a CT scan, white blood cell (WBC) counts, natural killer and neutrophil function assays, and IgG titers against human papillomavirus (HPV) 20. HPV20 was identified using the PCR method. The finding of the skin biopsy showed an irritated type of feature of seborrheic keratosis...
February 24, 2023: Clinics and Practice
https://read.qxmd.com/read/36851285/innate-and-adaptive-immunity-during-sars-cov-2-infection-biomolecular-cellular-markers-and-mechanisms
#15
REVIEW
Brent Brown, Vanshika Ojha, Ingo Fricke, Suhaila A Al-Sheboul, Chinua Imarogbe, Tanya Gravier, Michael Green, Lori Peterson, Ivoyl P Koutsaroff, Ayça Demir, Jonatane Andrieu, Chiuan Yee Leow, Chiuan Herng Leow
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, other human coronaviruses (hCoVs) exist. Historical pandemics include smallpox and influenza, with efficacious therapeutics utilized to reduce overall disease burden through effectively targeting a competent host immune system response. The immune system is composed of primary/secondary lymphoid structures with initially eight types of immune cell types, and many other subtypes, traversing cell membranes utilizing cell signaling cascades that contribute towards clearance of pathogenic proteins...
February 10, 2023: Vaccines
https://read.qxmd.com/read/36608264/pge-2-expression-by-hpv6-11-induced-respiratory-papillomas-blocks-nk-cell-activation-in-patients-with-recurrent-respiratory-papillomatosis
#16
JOURNAL ARTICLE
Mohd Israr, Fung Lam, James DeVoti, Emily M Mace, Christopher Papayannakos, Allan Abramson, Bettie M Steinberg, Vincent R Bonagura
Recurrent respiratory papillomatosis (RRP), a rare chronic disease caused primarily by human papillomavirus (HPV) types 6 and 11, consists of repeated growth of premalignant papillomas in the airway. RRP is characterized by multiple abnormalities in innate and adaptive immunity. Natural killer (NK) cells play important roles in immune surveillance and are part of the innate immune responses that help prevent tumor growth. We identified that papillomas lack classical class I MHC and retain non-classical class I MHC expression...
January 6, 2023: European Journal of Immunology
https://read.qxmd.com/read/36203656/molecular-classification-of-human-papillomavirus-positive-cervical-cancers-based-on-immune-signature-enrichment
#17
JOURNAL ARTICLE
Guanghui Song, Jiangti Luo, Shaohan Zou, Fang Lou, Tianfang Zhang, Xiaojun Zhu, Jianhua Yang, Xiaosheng Wang
Background: Human papillomavirus-positive (HPV+) cervical cancers are highly heterogeneous in clinical and molecular characteristics. Thus, an investigation into their heterogeneous immunological profiles is meaningful in providing both biological and clinical insights into this disease. Methods: Based on the enrichment of 29 immune signatures, we discovered immune subtypes of HPV+ cervical cancers by hierarchical clustering. To explore whether this subtyping method is reproducible, we analyzed three bulk and one single cell transcriptomic datasets...
2022: Frontiers in Public Health
https://read.qxmd.com/read/36159998/increased-expression-of-sycp2-predicts-poor-prognosis-in-patients-suffering-from-breast-carcinoma
#18
JOURNAL ARTICLE
Hongyan Zheng, Xiaorong Guo, Nan Li, Luyao Qin, Xiaoqing Li, Ge Lou
Overexpression of synaptonemal complex protein-2 ( SYCP2 ) has been identified in various human papillomavirus (HPV)-related carcinomas, whereas its significant role in breast carcinoma remains unclear. The aim of this study was to elucidate the prognostic value and potential function of SYCP2 in breast carcinoma. Herein, data for breast carcinoma patients from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas database (TCGA) were analyzed. The enrichment analysis of SYCP2 including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Friends, and GSEA was performed...
2022: Frontiers in Genetics
https://read.qxmd.com/read/36013065/hpv-positive-and-negative-cervical-cancers-are-immunologically-distinct
#19
JOURNAL ARTICLE
Andris M Evans, Mikhail Salnikov, Steven F Gameiro, Saman Maleki Vareki, Joe S Mymryk
Although infection with human papillomavirus (HPV) is associated with nearly all cervical cancers (CC), a small proportion are HPV-negative. Recently, it has become clear that HPV-negative CC represent a distinct disease phenotype compared to HPV-positive disease and exhibit increased mortality. In addition, variations between different HPV types associated with CC have been linked to altered molecular pathology and prognosis. We compared the immune microenvironments of CC caused by HPV α9 species (HPV16-like), HPV α7 species (HPV18-like) and HPV-negative disease...
August 18, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/36000446/single-cell-rna-seq-dissects-cellular-heterogeneity-and-identifies-two-tumor-suppressing-immune-cell-subclusters-in-hpv-related-cervical-adenosquamous-carcinoma
#20
JOURNAL ARTICLE
Xiaohui Li, Min Zhang, Tianyu Lei, Wenxue Zou, Rui Huang, Fuhao Wang, Qingyu Huang, Cong Wang, Chao Liu
The intra-tumor heterogeneity of human papillomavirus (HPV)-related cervical cancer remains poorly defined. We performed single-cell RNA sequencing on 18,046 individual cells derived from two HPV-related cervical adenosquamous carcinoma samples to analyze the transcriptional heterogeneity of both epithelial and immune constituents, identifying 7 epithelial (Epi1-7) and 11 immune sub-clusters. Based on expression of known cervical cancer markers, Epi1-2 primarily displayed features of adenocarcinoma, whereas Epi3-6 were instead characterized by features of squamous carcinoma...
August 24, 2022: Journal of Medical Virology
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