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https://www.readbyqxmd.com/read/29772246/preterm-birth-disrupts-cerebellar-development-by-affecting-granule-cell-proliferation-program-and-bergmann-glia
#1
Igor Y Iskusnykh, Randal K Buddington, Victor V Chizhikov
Preterm birth is a leading cause of long-term motor and cognitive deficits. Clinical studies suggest that some of these deficits result from disruption of cerebellar development, but the mechanisms that mediate cerebellar abnormalities in preterm infants are largely unknown. Furthermore, it remains unclear whether preterm birth and precocious exposure to the ex-utero environment directly disrupt cerebellar development or indirectly by increasing the probability of cerebellar injury, including that resulting from clinical interventions and protocols associated with the care of preterm infants...
May 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29767802/sitting-together-and-reaching-to-play-start-play-protocol-for-a-multisite-randomized-controlled-efficacy-trial-on-intervention-for-infants-with-neuromotor-disorders
#2
Regina T Harbourne, Stacey C Dusing, Michele A Lobo, Sarah Westcott-McCoy, James Bovaird, Susan Sheridan, James C Galloway, Hui-Ju Chang, Lin-Ya Hsu, Natalie Koziol, Emily C Marcinowski, Iryna Babik
Background: There is limited research examining the efficacy of early physical therapy on infants with neuromotor dysfunction. In addition, most early motor interventions have not been directly linked to learning, despite the clear association between motor activity and cognition during infancy. Objective: The aim of this project is to evaluate the efficacy of Sitting Together And Reaching To Play (START-Play), an intervention designed to target sitting, reaching, and motor-based problem solving to advance global development in infants with motor delays or neuromotor dysfunction...
June 1, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29766496/infant-motor-development-in-autism-spectrum-disorder-a-synthesis-and-meta-analysis
#3
Kelsey L West
Studies of infant motor development in autism spectrum disorder (ASD) have increased in recent years. This article synthesized this literature through meta-analysis to assess (a) whether infant motor ability differs in ASD relative to neurotypical controls; and (b) whether motor ability and communication are related in infants with ASD. Study 1 aggregated data from 1,953 infants with ASD (ages 3.0-42.0 months), and Study 2 included 890 infants with ASD (age 6.0-42.9 months). Study 1 revealed that infant motor ability differed significantly in ASD compared with neurotypical infants-this difference was robust to variation in measurement and design...
May 15, 2018: Child Development
https://www.readbyqxmd.com/read/29765885/comparison-of-second-and-third-editions-of-the-bayley-scales-in-children-with-suspected-developmental-delay
#4
You Gyoung Yi, In Young Sung, Jin Sook Yuk
Objective: To compare the scores of the Bayley Scales of Infant Development second edition (BSID-II) and the third edition, Bayley-III, in children with suspected developmental delay and to determine the cutoff score for developmental delay in the Bayley-III. Methods: Children younger than 42 months (n=62) with suspected developmental delay who visited our department between 2014 and 2015 were assessed with both the BSID-II and Bayley-III tests. Results: The mean Bayley-III Cognitive Language Composite (CLC) score was 5...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29763437/postnatal-colonization-with-human-infant-type-bifidobacterium-species-alters-behavior-of-adult-gnotobiotic-mice
#5
Berkley Luk, Surabi Veeraragavan, Melinda Engevik, Miriam Balderas, Angela Major, Jessica Runge, Ruth Ann Luna, James Versalovic
Accumulating studies have defined a role for the intestinal microbiota in modulation of host behavior. Research using gnotobiotic mice emphasizes that early microbial colonization with a complex microbiota (conventionalization) can rescue some of the behavioral abnormalities observed in mice that grow to adulthood completely devoid of bacteria (germ-free mice). However, the human infant and adult microbiomes vary greatly, and effects of the neonatal microbiome on neurodevelopment are currently not well understood...
2018: PloS One
https://www.readbyqxmd.com/read/29760105/triplets-birthweight-and-handedness
#6
Kauko Heikkilä, Catharina E M Van Beijsterveldt, Jari Haukka, Matti Iivanainen, Aulikki Saari-Kemppainen, Karri Silventoinen, Dorret I Boomsma, Yoshie Yokoyama, Eero Vuoksimaa
The mechanisms behind handedness formation in humans are still poorly understood. Very low birthweight is associated with higher odds of left-handedness, but whether this is due to low birthweight itself or premature birth is unknown. Handedness has also been linked to development, but the role of birthweight behind this association is unclear. Knowing that birthweight is lower in multiple births, triplets being about 1.5 kg lighter in comparison with singletons, and that multiples have a higher prevalence of left-handedness than singletons, we studied the association between birthweight and handedness in two large samples consisting exclusively of triplets from Japan ( n = 1,305) and the Netherlands ( n = 947)...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29753346/clinical-outcome-assessments-use-of-normative-data-in-a-pediatric-rare-disease
#7
Dawn Phillips, Beth Leiro
Pediatric rare diseases present unique challenges in clinical trial design and in selection of clinical outcome assessments (COAs) used to support claims in medical product labeling. COAs that discriminate level of function relative to a normative sample are particularly important in the pediatric rare disease setting because the literature is often void of natural history data. Pediatric rare disease clinical trials will often include a wide age distribution. Gross and fine motor skills, communication, cognition, and independence in activities of daily living vary by age, and it may be difficult to distinguish between treatment effect and change due to developmental maturation...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29752957/early-human-motor-development-from-variation-to-the-ability-to-vary-and-adapt
#8
REVIEW
Mijna Hadders-Algra
This review summarizes early human motor development. From early fetal age motor behavior is based on spontaneous neural activity: activity of networks in the brainstem and spinal cord that is modulated by supraspinal activity. The supraspinal activity, first primarily brought about by the cortical subplate, later by the cortical plate, induces movement variation. Initially, movement variation especially serves exploration; its associated afferent information is primarily used to sculpt the developing nervous system, and less to adapt motor behavior...
May 9, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29735386/neurobehavioural-outcome-in-6-18-year-old-children-after-trauma-in-pregnancy-case-control-study
#9
B J van der Knoop, K J Oostrom, I A Zonnenberg, M M van Weissenbruch, R J Vermeulen, J I P de Vries
BACKGROUND: Maternal trauma complicates pregnancy in approximately 7%. Long-term development of children exposed to maternal trauma is unknown. AIM: To determine neurobehavioural outcome of children (6-18 years) born after maternal trauma in pregnancy compared to a matched control group. STUDY DESIGN: Case-control study performed at a tertiary medical centre. SUBJECTS: All consecutive children born after maternal hospitalization for trauma during pregnancy between 1995 and 2005...
April 12, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29730131/relationship-between-mother-infant-mutual-dyadic-responsiveness-and-premature-infant-development-as-measured-by-the-bayley-iii-at-6-weeks-corrected-age
#10
Rosemary C White-Traut, Kristin M Rankin, Joe Yoder, Laura Zawacki, Suzann Campbell, Meredith Censullo, Karen Kavanaugh, Kathleen F Norr
BACKGROUND: The quality of mother-preterm infant interaction has been identified as a key factor in influencing the infant's later development and language acquisition. The relationship between mother-infant responsiveness and later development may be evident early in infancy, a time period which has been understudied. AIM: Describe the relationship between mother-infant mutual dyadic responsiveness and premature infant development. DESIGN: This study employed a secondary analysis of data from the 6-week corrected age (CA) follow-up visit of the Hospital-Home Transition: Optimizing Prematures' Environment (H-HOPE) study, a randomized clinical trial testing the efficacy of a mother- and infant- focused intervention for improving outcomes among premature infants...
May 3, 2018: Early Human Development
https://www.readbyqxmd.com/read/29724577/spontaneous-movements-of-preterm-infants-is-associated-with-outcome-of-gross-motor-development
#11
Saori Miyagishima, Tadayoshi Asaka, Kaori Kamatsuka, Naoki Kozuka, Masaki Kobayashi, Lisa Igarashi, Tsukasa Hori, Hiroyuki Tsutsumi
AIMS: We conducted a longitudinal cohort study to analyze the relationship between outcome of gross motor development in preterm infants and factors that might affect their development. METHODS: Preterm infants with a birth weight of <1500 g were recruited. We measured spontaneous antigravity limbs movements by 3D motion capture system at 3 months corrected age. Gross motor developmental outcomes at 6 and 12 months corrected age were evaluated using the Alberta Infant Motor Scale (AIMS)...
April 30, 2018: Brain & Development
https://www.readbyqxmd.com/read/29724352/neonatal-brain-injury-and-timing-of-neurodevelopmental-assessment-in-patients-with-congenital-heart-disease
#12
Shabnam Peyvandi, Vann Chau, Ting Guo, Duan Xu, Hannah C Glass, Anne Synnes, Kenneth Poskitt, A James Barkovich, Steven P Miller, Patrick S McQuillen
BACKGROUND: Brain injury (BI) is reported in 60% of newborns with critical congenital heart disease as white matter injury (WMI) or stroke. Neurodevelopmental (ND) impairments are reported in these patients. The relationship between neonatal BI and ND outcome has not been established. OBJECTIVES: This study sought to determine the association between peri-operative BI and ND outcomes in infants with single ventricle physiology (SVP) and d-transposition of the great arteries (d-TGA)...
May 8, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29722482/five-year-neurodevelopment-outcomes-of-perinatally-hiv-infected-children-on-early-limited-or-deferred-continuous-antiretroviral-therapy
#13
Barbara Laughton, Morna Cornell, Martin Kidd, Priscilla Estelle Springer, Els Françoise Marie-Thérèse Dobbels, Anita Janse Van Rensburg, Kennedy Otwombe, Abdel Babiker, Diana M Gibb, Avy Violari, Mariana Kruger, Mark Fredric Cotton
INTRODUCTION: Early antiretroviral therapy (ART) has improved neurodevelopmental outcomes of HIV-infected (HIV-positive) children; however, little is known about the longer term outcomes in infants commencing early ART or whether temporary ART interruption might have long-term consequences. In the children with HIV early antiretroviral treatment (CHER) trial, HIV-infected infants ≤12 weeks of age with CD4 ≥25% were randomized to deferred ART (ART-Def); immediate time-limited ART for 40 weeks (ART-40W) or 96 weeks (ART-96W)...
May 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29721246/acute-encephalopathy-with-biphasic-seizures-and-late-reduced-diffusion-associated-with-streptococcus-sanguinis-sepsis
#14
Hitoshi Awaguni, Jun Shinozuka, Shin-Ichiro Tanaka, Sayaka Kadowaki, Shigeru Makino, Rikken Maruyama, Yosuke Shigematsu, Kenji Hamaoka, Shinsaku Imashuku
Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) develops in association with systemic as well as central nervous system (CNS) viral or bacterial infections. AESD is most often noted with influenza or human herpesvirus 6 infection in previously healthy infants. However, AESD has also been reported in an infant with developmental retardation and in a mentally and motor-disabled adolescent. Here, we report the case of a 4- year-old female with significant development delay due to spinal muscular atrophy, who developed AESD during Streptococcus sanguinis sepsis with no apparent CNS infection...
March 22, 2018: Pediatric Reports
https://www.readbyqxmd.com/read/29718853/pediatric-tuina-for-promoting-growth-and-development-of-preterm-infants-a-protocol-for-the-systematic-review-of-randomized-controlled-trail
#15
Xinghe Zhang, Taipin Guo, Bowen Zhu, Qing Gao, Hourong Wang, Xiantao Tai, Fujie Jing
BACKGROUND: Preterm infants are babies born alive before 37 weeks. Many survived infants concomitant with defects of growth and development, a lifetime of disability usually as following when insufficient intervention. In early intervention of preterm infants, pediatric Tuina shows good effect in many Chinese and some English clinical trials. This systematic review is aimed to evaluate the efficacy and safety of pediatric Tuina for promoting growth and development of preterm infants. METHODS: The electronic databases of Cochrane Library, MEDLINE, EBASE, Web of Science, Springer, World Health Organization International Clinical Trials Registry Platform, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wan-fang database, Chinese Scientific Journal Database, and other databases will be searched from establishment to April 1, 2018...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29712949/association-between-maternal-exposure-to-phthalates-and-lower-language-ability-in-offspring-derived-from-hair-metabolome-analysis
#16
Beatrix Jones, Ting-Li Han, Thibaut Delplancke, Elizabeth J McKenzie, Jamie V de Seymour, Mei Chien Chua, Kok Hian Tan, Philip N Baker
The fetus undergoes a crucial period of neurodevelopment in utero. The maternal hair metabolome provides an integrated record of the metabolic state of the mother prior to, and during pregnancy. We investigated whether variation in the maternal hair metabolome was associated with neurodevelopmental differences across infants. Maternal hair samples and infant neurocognitive assessments (using the Bayley III Scales of Infant Development at 24 months) were obtained for 373 infant-mother dyads between 26-28 weeks' gestation from the Growing Up in Singapore Towards Healthy Outcomes cohort...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29710034/the-relationship-between-maternal-serum-vitamin-d-levels-and-infant-neurodevelopment-and-anthropometry-a-prospective-observational-study
#17
Mei-Zhu Chi, Lin Zhu, Zeng-Li Zhang, Fang-Fang Jin, Hao-Ran Shao, Jia-Yin Zheng, Chao Wu, Guang-Qiong Hu
This study was designed to determine whether there is a relationship between serum vitamin D levels and neurodevelopment and anthropometry in Chinese infants. A prospective cohort study with 160 women who gave birth to 160 healthy full-term infants and who were followed up for 6 mo was done. It included 80 pregnant women with vitamin D deficiency, and the other 80 pregnant women were enrolled matching the age and delivery method with a 25(OH)D level of more than 50 nmol/L. There was a signicant intergroup difference in length, weight or head circumference at birth (p<0...
2018: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29708221/relationships-between-full-day-arm-movement-characteristics-and-developmental-status-in-infants-with-typical-development-as-they-learn-to-reach-an-observational-study
#18
Joanne Shida-Tokeshi, Christianne J Lane, Ivan A Trujillo-Priego, Weiyang Deng, Douglas L Vanderbilt, Gerald E Loeb, Beth A Smith
Background: Advances in wearable sensor technology now allow us to quantify the number, type and kinematic characteristics of bouts of infant arm movement made across a full day in the natural environment. Our aim here was to determine whether the amount and kinematic characteristics of arm movements made across the day in the natural environment were related to developmental status in infants with typical development as they learned to reach for objects using their arms. Methods: We used wearable sensors to measure arm movement across days and months as infants developed arm reaching skills...
April 5, 2018: Gates open research
https://www.readbyqxmd.com/read/29707797/can-very-early-music-interventions-promote-at-risk-infants-development
#19
REVIEW
Paula Virtala, Eino Partanen
Music and musical activities are often a natural part of parenting. As accumulating evidence shows, music can promote auditory and language development in infancy and early childhood. It may even help to support auditory and language skills in infants whose development is compromised by heritable conditions, like the reading deficit dyslexia, or by environmental factors, such as premature birth. For example, infants born to dyslexic parents can have atypical brain responses to speech sounds and subsequent challenges in language development...
April 30, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29696050/are-the-norms-of-bayley-screening-test-appropriate-for-persian-language-children
#20
Farin Soleimani, Nadia Azari, Roshanak Vameghi, Firoozeh Sajedi, Soheila Shahshahani, Hossein Karimi, Adis Kraskian, Amin Shahrokhi, Robab Teymouri, Masoud Gharib, Nayereh Mehdipour
Objective: We aimed to assess the distribution of the Bayley screening test by age, and compare developmental risk category distributions between Persian language children and reference norms. Materials & Methods: A representative sample of 417 children, 1 to 42-months-old, by consecutive sampling from health -care centers were enrolled, during 2014 to 2015 in Tehran, Iran. The cognitive, language and motor development of children were evaluated using Bayley screening test...
2018: Iranian Journal of Child Neurology
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