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infant motor development

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https://www.readbyqxmd.com/read/28522659/validation-of-an-mri-brain-injury-and-growth-scoring-system-in-very-preterm-infants-scanned-at-29-to-35-week-postmenstrual-age
#1
J M George, S Fiori, J Fripp, X K Pannek, X J Bursle, X R X Moldrich, X A Guzzetta, X A Coulthard, X R S Ware, X S E Rose, X P B Colditz, X R N Boyd
BACKGROUND AND PURPOSE: The diagnostic and prognostic potential of brain MR imaging before term-equivalent age is limited until valid MR imaging scoring systems are available. This study aimed to validate an MR imaging scoring system of brain injury and impaired growth for use at 29 to 35 weeks postmenstrual age in infants born at <31 weeks gestational age. MATERIALS AND METHODS: Eighty-three infants in a prospective cohort study underwent early 3T MR imaging between 29 and 35 weeks' postmenstrual age (mean, 32(+2) ± 1(+3) weeks; 49 males, born at median gestation of 28(+4) weeks; range, 23(+6)-30(+6) weeks; mean birthweight, 1068 ± 312 g)...
May 18, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28506824/hypoxia-and-nicotine-effects-on-pituitary-adenylate-cyclase-activating-polypeptide-pacap-and-its-receptor-1-pac1-in-the-developing-piglet-brainstem
#2
J Huang, K A Waters, R Machaalani
Pituitary adenylate cyclase activating polypeptide (PACAP) and its cognate receptor 1 (PAC1), have been implicated in the pathophysiology of the Sudden Infant Death Syndrome (SIDS). Two main risk factors for SIDS are prone sleeping and cigarette smoke exposure. Using piglet models of these risk factors, intermittent hypercapnic hypoxia (IHH-mimicking rebreathing in prone position) and nicotine (main reinforcing element of cigarettes), this study aimed to determine their effects on PACAP and PAC1 protein expression in the medulla...
May 12, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28506665/motor-development-of-preterm-infants-assessed-by-the-alberta-infant-motor-scale-systematic-review-article
#3
REVIEW
Rubia do N Fuentefria, Rita de Cássia Silveira, Renato S Procianoy
OBJECTIVE: Premature newborns are considered at risk for motor development deficits, leading to the need for monitoring in early life. The aim of this study was to systematically review the literature about gross motor development of preterm infants, assessed by the Alberta Infant Motor Scale (AIMS) to identify the main outcomes in development. DATA SOURCE: Systematic review of studies published from 2006 to 2015, indexed in Pubmed, Scielo, Lilacs, and Medline databases in English and Portuguese...
May 12, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28497181/new-directions-in-fetal-surgery-for-myelomeningocele
#4
Sandra K Kabagambe, Y Julia Chen, Melissa A Vanover, Payam Saadai, Diana L Farmer
The treatment of children with myelomeningocele (MMC) has improved over time, from supportive management to early postnatal closure to prenatal repair of the defect. The Management of Myelomeningocele Study (MOMS) showed that prenatal repair of MMC resulted in improved neurological outcomes compared to postnatal closure. Follow-up studies showed that prenatal repair was, as with any other fetal intervention, associated with higher rates of obstetrical complications. There was no significant difference in urological outcomes...
May 11, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28486543/preterm-brain-injury-on-term-equivalent-age-mri-in-relation-to-perinatal-factors-and-neurodevelopmental-outcome-at-two-years
#5
Margaretha J Brouwer, Karina J Kersbergen, Britt J M van Kooij, Manon J N L Benders, Ingrid C van Haastert, Corine Koopman-Esseboom, Jeffrey J Neil, Linda S de Vries, Hiroyuki Kidokoro, Terrie E Inder, Floris Groenendaal
OBJECTIVES: First, to apply a recently extended scoring system for preterm brain injury at term-equivalent age (TEA-)MRI in a regional extremely preterm cohort; second, to identify independent perinatal factors associated with this score; and third, to assess the prognostic value of this TEA-MRI score with respect to early neurodevelopmental outcome. STUDY DESIGN: 239 extremely preterm infants (median gestational age [range] in weeks: 26.6 [24.3-27.9]), admitted to the Wilhelmina Children's Hospital between 2006 and 2012 were included...
2017: PloS One
https://www.readbyqxmd.com/read/28482742/neurodevelopmental-outcomes-in-22-children-with-microcephaly-of-different-etiologies
#6
Eliza Gordon-Lipkin, Maura Blakemore Gentner, Rebecca German, Mary L Leppert
We examined longitudinal neurodevelopmental outcomes in a series of infants with microcephaly. Retrospective review identified neonatal intensive care unit follow-up clinic patients with a diagnostic code of microcephaly, verified by head circumference less than the fifth precentile (WHO growth curves). Data were collected regarding clinical history and developmental assessments by Capute Scales and gross motor age equivalent. Developmental Quotient (DQ) was age adjusted up until 2 years for preterm infants...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28481536/discovery-of-a-small-molecule-probe-that-post-translationally-stabilizes-the-survival-motor-neuron-protein-for-the-treatment-of-spinal-muscular-atrophy
#7
Anne Rietz, Hongxia Li, Kevin M Quist, Jonathan J Cherry, Christian L Lorson, Barrington G Burnett, Nicholas L Kern, Alyssa N Calder, Melanie Fritsche, Hrvoje Lusic, Patrick J Boaler, Sungwoon Choi, Xuechao Xing, Marcie A Glicksman, Gregory D Cuny, Elliot J Androphy, Kevin J Hodgetts
Spinal muscular atrophy (SMA) is the leading genetic cause of infant death. We previously developed a high-throughput assay that employs an SMN2-luciferase reporter allowing identification of compounds that act transcriptionally, enhance exon recognition, or stabilize the SMN protein. We describe optimization and characterization of an analog suitable for in vivo testing. Initially, we identified analog 4m that had good in vitro properties but low plasma and brain exposure in a mouse PK experiment due to short plasma stability; this was overcome by reversing the amide bond and changing the heterocycle...
May 19, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28471442/an-antenatal-marker-of-neurodevelopmental-outcomes-in-infants-with-congenital-heart-disease
#8
S Siddiqui, W P Fifer, M Ordonez-Retamar, J D Nugent, I A Williams
OBJECTIVE: Prenatal exposures are known to alter fetal neurodevelopment and autonomic control. We aimed to explore the correlation between fetal autonomic activity, measured by fetal heart rate variability, and 18-month developmental outcome in subjects with congenital heart disease. STUDY DESIGN: From 2010 to 2013, 5 fetuses with hypoplastic left heart syndrome, 9 with transposition of the great arteries and 9 with tetralogy of Fallot were included in this prospective cohort study...
May 4, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28470384/first-60-fetal-in-utero-myelomeningocele-repairs-at-saint-louis-fetal-care-institute-in-the-post-moms-trial-era-hydrocephalus-treatment-outcomes-endoscopic-third-ventriculostomy-versus-ventriculo-peritoneal-shunt
#9
Samer K Elbabaa, Anne M Gildehaus, Matthew J Pierson, J Andrew Albers, Emanuel J Vlastos
INTRODUCTION: The published results of the Management of Myelomeningocele Study (MOMS) trial in 2011 showed improved outcomes (reduced need for shunting, decreased incidence of Chiari II malformation, and improved scores of mental development and motor function) in the fetal prenatal repair group compared to the postnatal group. Historically, endoscopic third ventriculostomy (ETV) remains as a controversial hydrocephalus treatment option with high failure rates in pediatric patients with a history of myelomeningocele (MMC)...
May 3, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28467888/auditory-object-perception-a-neurobiological-model-and-prospective-review
#10
Julie A Brefczynski-Lewis, James W Lewis
Interaction with the world is a multisensory experience, but most of what is known about the neural correlates of perception comes from studying vision. Auditory inputs enter cortex with its own set of unique qualities, and leads to use in oral communication, speech, music, and the understanding of emotional and intentional states of others, all of which are central to the human experience. To better understand how the auditory system develops, recovers after injury, and how it may have transitioned in its functions over the course of hominin evolution, advances are needed in models of how the human brain is organized to process real-world natural sounds and "auditory objects"...
April 30, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28467344/growth-and-growth-hormone-insulin-like-growth-factor-i-gh-igf-i-axis-in-chronic-anemias
#11
Ashraf T Soliman, Vincenzo De Sanctis, Mohamed Yassin, Ashraf Adel
Anaemia is a global public health problem affecting both developing and developed countries with major consequences for human health as well as social and economic development. It occurs at all stages of the life cycle, but is more prevalent in pregnant women and young children. Iron deficiency anaemia (IDA) was considered to be among the most important contributing factors to the global burden of disease. Prolonged and/or chronic anemia has a negative effect on linear growth especially during the rapid phases (infancy and puberty)...
April 28, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28459271/maternal-posttraumatic-stress-disorder-and-infant-developmental-outcomes-in-a-south-african-birth-cohort-study
#12
Nastassja Koen, Kirsty Brittain, Kirsten A Donald, Whitney Barnett, Sheri Koopowitz, Karen Maré, Heather J Zar, Dan J Stein
OBJECTIVE: To investigate the association between maternal posttraumatic stress disorder (PTSD) and infant development in a South African birth cohort. METHOD: Data from the Drakenstein Child Health Study were analyzed. Maternal psychopathology was assessed using self-report and clinician-administered interviews; and 6-month infant development using the Bayley III Scales of Infant Development. Linear regression analyses explored associations between predictor and outcome variables...
May 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28459258/spatial-exploration-and-changes-in-infant-mother-dyads-around-transitions-in-infant-locomotion
#13
Sabrina L Thurman, Daniela Corbetta
Infants' motor skill development triggers changes in parent-infant interactions, exploration, and play behaviors, particularly during periods of locomotor transitions. We investigated how these transitions reorganized infants' and mothers' explorations of spatial layouts. Thirteen infants and their mothers were followed biweekly from the age of 6 to 17 months. This report focused on 2 periods of 6 sessions surrounding infants' hands-and-knees crawling and walking onsets. Infants' and mothers' activities were monitored during 10-min free-play sessions held in a laboratory room provided with toys and furniture...
May 1, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28458148/postural-control-strategies-differ-in-normal-weight-and-overweight-infants
#14
Danae Dinkel, Kailey Snyder, Victoria Molfese, Anastasia Kyvelidou
BACKGROUND: Evidence suggests obesity can have a negative influence on a child's motor development and postural control behavior. Little research has examined the impact of infant weight on gross motor behavior, particularly postural control at the onset of sitting. OBJECTIVE: The purpose of this study was to determine whether normal weight and overweight infants differed in their postural control strategies at the onset of sitting and one-month post onset of sitting...
April 13, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28452420/neurobehavioural-and-cognitive-development-in-infants-born-to-mothers-with-eating-disorders
#15
M Barona, E Taborelli, F Corfield, S Pawlby, A Easter, U Schmidt, J Treasure, N Micali
INTRODUCTION: Although recent research has focused on the effects of maternal eating disorders (EDs) on children, little is known about the effect of maternal EDs on neurobiological outcomes in newborns and infants. This study is the first to investigate neurobehavioural regulation and cognitive development in newborns and infants of mothers with EDs. METHODS: Women with an active and past ED and healthy controls were recruited to a prospective longitudinal study during their first trimester or second trimester of pregnancy...
April 28, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28439323/caudal-regression-syndrome-a-case-series-of-a-rare-congenital-anomaly
#16
Yogesh Kumar, Nishant Gupta, Kusum Hooda, Pranav Sharma, Salil Sharma, Puneet Kochar, Daichi Hayashi
BACKGROUND: Caudal regression syndrome is a rare, neural tube defect characterized by an abnormal development of the caudal aspect of the vertebral column and the spinal cord., It results in neurological deficits ranging from bladder and bowel involvement to severe sensory and motor deficits in the lower limbs. Maternal diabetes, genetic factors and some teratogens have been shown to be associated with its pathogenesis. Caudal regression syndrome is usually diagnosed initially by antenatal ultrasound with more definitive diagnosis made by antenatal or postnatal MRI...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28437326/favorable-outcomes-of-preterm-infants-with-parenteral-nutrition-associated-liver-disease-treated-with-intravenous-fish-oil-based-lipid-emulsion
#17
Michael Sorrell, Alvaro Moreira, Kay Green, Rachel Jacob, Robin Tragus, Laura Keller, Amy Quinn, Donald McCurnin, Alice Gong, Abeer El Sakka, Naveen Mittal, Cynthia Blanco
OBJECTIVES: The aim of the study was to determine the acute and long-term outcomes of preterm infants treated with an intravenous fish oil-based lipid emulsion (FishLE) for parenteral nutrition-associated liver disease (PNALD). METHODS: Preterm infants 14 days to 24 months of age with anatomic short gut or severe intestinal dysmotility, serum direct bilirubin ≥4 mg/dL, and requiring >60% calories from parenteral nutrition were eligible. Enrolled infants received 1 g · kg · day of FishLE until resolution of direct hyperbilirubinemia or return of enteral nutrition...
May 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28433877/affordances-in-the-home-environment-for-motor-development-validity-and-reliability-for-the-use-in-daycare-setting
#18
Alessandra Bombarda Müller, Nadia Cristina Valentini, Paulo Felipe Ribeiro Bandeira
The range of stimuli provided by physical space, toys and care practices contributes to the motor, cognitive and social development of children. However, assessing the quality of child education environments is a challenge, and can be considered a health promotion initiative. This study investigated the validity of the criterion, content, construct and reliability of the Affordances in the Home Environment for Motor Development - Infant Scale (AHEMD-IS), version 3-18 months, for the use in daycare settings...
April 20, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28424357/thin-for-gestational-age-infants-are-at-increased-risk-of-neurodevelopmental-delay-at-2%C3%A2-years
#19
Sinéad M O'Neill, Geraldine Hannon, Ali S Khashan, J O'B Hourihane, Louise C Kenny, Mairead Kiely, Deirdre M Murray
BACKGROUND: Infants born small-for-gestational age (SGA) are at increased risk of developmental difficulties. Identifying those most at risk is challenging. We examined the effect of neonatal body composition and customised birthweight centiles on neurocognitive and behavioural outcomes at age 2. STUDY DESIGN: Prospective cohort study of term infants from the Cork BASELINE Birth Cohort Study classified into the following exposure groups: a birth weight <10th customised centile (SGA, n=51); body fat percentage at birth <10th centile (thin-for-gestational age (TGA, n=51)) or both SGA and TGA infants (small- and thin-for-gestational age (STGA), n=13)...
May 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28420388/association-between-maternal-intake-of-n-6-to-n-3-fatty-acid-ratio-during-pregnancy-and-infant-neurodevelopment-at-6-months-of-age-results-of-the-moceh-cohort-study
#20
Hyejin Kim, Hyesook Kim, Eunjung Lee, Yeni Kim, Eun-Hee Ha, Namsoo Chang
BACKGROUND & AIMS: Long-chain polyunsaturated fatty acids (LC-PUFAs) are essential for infant neurodevelopment. The nutritional adequacy of dietary LC-PUFAs depends not only on the LC-PUFAs intake but also on the n-6 to n-3 fatty acid ratio (n-6/n-3 PUFAs). This study aimed to identify the association between the maternal dietary n-6/n-3 PUFAs and motor and cognitive development of infants at 6 months of age. METHODS: We used data from 960 participants in the Mothers and Children's Environmental Health (MOCEH) study, which is a multi-center prospective cohort study...
April 18, 2017: Nutrition Journal
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