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https://www.readbyqxmd.com/read/28636317/downsizing-proto-oncogene-cfos-to-short-helix-constrained-peptides-that-bind-jun
#1
Daniel Baxter, Samuel R Perry, Timothy A Hill, W Mei Kok, Nathan R Zaccai, R Leo Brady, David P Fairlie, Jody M Mason
The oncogenic transcription factor activator protein-1 (AP-1) is a DNA-binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled-coil structure. This study reports on downsizing the proto-oncogene cFos protein (380 residues) to shorter peptides (37-25 residues) modified with helix-inducing constraints to enhance binding to Jun. A crystal structure is reported for a 37-residue Fos-derived peptide (FosW) bound to Jun. This guided iterative downsizing of FosW to shorter peptide sequences that were constrained into stable water-soluble α-helices by connecting amino acid side chains to form cyclic pentapeptide components...
June 21, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28634743/comminuted-olecranon-fractures-biomechanical-testing-of-locked-versus-minifragment-non-locked-plate-fixation
#2
David S Wellman, Scott M Tucker, Josh R Baxter, Nadine C Pardee, Lionel E Lazaro, Christopher S Smith, Dean G Lorich, David L Helfet
INTRODUCTION: Open reduction and internal fixation has long been accepted as optimal treatment for displaced olecranon fractures based on poor results seen with conservative management. With the presence of comminution, tension-band wiring constructs are contraindicated due to tendency to compress through fragments, thereby shortening the articular segment. Therefore, plate fixation is typically employed. Our hypothesis was that in a comminuted fracture model, 2.7 mm reconstruction plating without locking screws will perform equally to 3...
June 20, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28634647/erratum-to-training-guidelines-for-endovascular-stroke-intervention-an-international-multi-society-consensus-document
#3
S D Lavine, K Cockroft, B Hoh, N Bambakidis, A A Khalessi, H Woo, H Riina, A Siddiqui, J A Hirsch, W Chong, H Rice, J Wenderoth, P Mitchell, A Coulthard, T J Signh, C Phatouros, M Khangure, P Klurfan, K Ter Brugge, D Iancu, T Gunnarsson, O Jansen, M Muto, I Szikora, L Pierot, P Brouwer, J Gralla, S Renowden, T Andersson, J Fiehler, F Turjman, P White, A C Januel, L Spelle, Z Kulcsar, R Chapot, A Biondi, S Dima, C Taschner, M Szajner, A Krajina, N Sakai, Y Matsumaru, S Yoshimura, M Ezura, T Fujinaka, K Iihara, A Ishii, T Higashi, M Hirohata, A Hyodo, Y Ito, M Kawanishi, H Kiyosue, E Kobayashi, S Kobayashi, N Kuwayama, Y Matsumoto, S Miyachi, Y Murayama, I Nagata, I Nakahara, S Nemoto, Y Niimi, H Oishi, J Satomi, T Satow, K Sugiu, M Tanaka, T Terada, H Yamagami, O Diaz, P Lylyk, M V Jayaraman, A Patsalides, C D Gandhi, S K Lee, T Abruzzo, B Albani, S A Ansari, A S Arthur, B W Baxter, K R Bulsara, M Chen, J E Delgado Almandoz, J F Fraser, D V Heck, S W Hetts, M S Hussain, R P Klucznik, T M Leslie-Mawzi, W J Mack, R A McTaggart, P M Meyers, J Mocco, C J Prestigiacomo, G L Pride, P A Rasmussen, R M Starke, P J Sunenshine, R W Tarr, D F Frei, M Ribo, R G Nogueira, O O Zaidat, T Jovin, I Linfante, D Yavagal, D Liebeskind, R Novakovic, S Pongpech, G Rodesch, M Soderman, A Taylor, T Krings, D Orbach, L Picard, D C Suh, H Q Zhang
No abstract text is available yet for this article.
June 20, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28628441/novel-retinal-lesion-in-ebola-survivors-sierra-leone-2016
#4
Paul J Steptoe, Janet T Scott, Julia M Baxter, Craig K Parkes, Rahul Dwivedi, Gabriela Czanner, Matthew J Vandy, Fayiah Momorie, Alimamy D Fornah, Patrick Komba, Jade Richards, Foday Sahr, Nicholas A V Beare, Malcolm G Semple
We conducted a case-control study in Freetown, Sierra Leone, to investigate ocular signs in Ebola virus disease (EVD) survivors. A total of 82 EVD survivors with ocular symptoms and 105 controls from asymptomatic civilian and military personnel and symptomatic eye clinic attendees underwent ophthalmic examination, including widefield retinal imaging. Snellen visual acuity was <6/7.5 in 75.6% (97.5% CI 63%-85.7%) of EVD survivors and 75.5% (97.5% CI 59.1%-87.9%) of controls. Unilateral white cataracts were present in 7...
July 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28627356/aquatic-therapy-for-children-with-duchenne-muscular-dystrophy-a-pilot-feasibility-randomised-controlled-trial-and-mixed-methods-process-evaluation
#5
Daniel Hind, James Parkin, Victoria Whitworth, Saleema Rex, Tracey Young, Lisa Hampson, Jennie Sheehan, Chin Maguire, Hannah Cantrill, Elaine Scott, Heather Epps, Marion Main, Michelle Geary, Heather McMurchie, Lindsey Pallant, Daniel Woods, Jennifer Freeman, Ellen Lee, Michelle Eagle, Tracey Willis, Francesco Muntoni, Peter Baxter
BACKGROUND: Duchenne muscular dystrophy (DMD) is a rare disease that causes the progressive loss of motor abilities such as walking. Standard treatment includes physiotherapy. No trial has evaluated whether or not adding aquatic therapy (AT) to land-based therapy (LBT) exercises helps to keep muscles strong and children independent. OBJECTIVES: To assess the feasibility of recruiting boys with DMD to a randomised trial evaluating AT (primary objective) and to collect data from them; to assess how, and how well, the intervention and trial procedures work...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28625065/physical-texturing-for-superhydrophobic-polymeric-surfaces-a-design-perspective
#6
Jing Yang Quek, Christopher L Magee, Hong Yee Low
Surface wetting on textured surface is classically explained by Cassie-Baxter or Wenzel's theories. However, in recent years, an increasing number of complex surface topographies with super-hydrophobic properties were achieved without prediction or simulation using these theories. One example is biomimetic surfaces. In many instances, theories were used to explain surface properties found in nature but have not led to or predicted the complex topographies. Although new wetting theories continue to emerge, there is not yet a set of design rules to guide the selection of surface topographies to achieve super-hydrophobicity...
June 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28622087/body-physique-and-proportionality-of-brazilian-female-artistic-gymnasts
#7
Sarita Bacciotti, Adam Baxter-Jones, Adroaldo Gaya, José Maia
This study aimed to identify physique characteristics (anthropometry, somatotype, body proportionality) of Brazilian female artistic gymnasts, and to compare them across competitive levels (sub-elite versus non-elite) within competitive age-categories. Two hundred forty-nine female gymnasts (68 sub-elite; 181 non-elite) from 26 Brazilian gymnastics clubs, aged 9-20 years and split into four age-categories, were sampled. Gymnasts were assessed for 16 anthropometric traits (height, weight, lengths, widths, girths, and skinfolds); somatotype was determined according to Heath-Carter method, body fat was estimated by bioimpedance, and proportionality was computed based on the z-phantom strategy...
June 16, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28621011/yoga-for-the-management-of-pain-and-sleep-in-rheumatoid-arthritis-a-pilot-randomized-controlled-trial
#8
Lesley Ward, Simon Stebbings, Josie Athens, Daniel Cherkin, G David Baxter
OBJECTIVE: The aim of the present study was to determine the feasibility of a relaxation-based yoga intervention for rheumatoid arthritis, designed and reported in accordance with Delphi recommendations for yoga interventions for musculoskeletal conditions. METHODS: Participants were recruited from a hospital database, and randomized to either eight weekly 75-min yoga classes or a usual care control. Feasibility was determined by recruitment rates, retention, protocol adherence, participant satisfaction and adverse events...
June 16, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28620661/brutus-and-its-paralogs-bts-like1-and-bts-like2-encode-important-negative-regulators-of-the-iron-deficiency-response-in-arabidopsis-thaliana
#9
Maria N Hindt, Garo Z Akmakjian, Kara L Pivarski, Tracy Punshon, Ivan Baxter, David E Salt, Mary Lou Guerinot
Iron (Fe) is required for plant health, but it can also be toxic when present in excess. Therefore, Fe levels must be tightly controlled. The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Loss of both of these E3 ligases enhances tolerance to Fe deficiency. We further generated a triple mutant with loss of both BTS paralogs and a partial loss of BTS expression that exhibits even greater tolerance to Fe-deficient conditions and increased Fe accumulation without any resulting Fe toxicity effects...
June 16, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28618226/nanotexturing-of-conjugated-polymers-via-one-step-maskless-oxygen-plasma-etching-for-enhanced-tunable-wettability
#10
Youhua Jiang, Jian Xu, Junghoon Lee, Ke Du, Eui-Hyeok Yang, Myoung-Woon Moon, Chang-Hwan Choi
A one-step maskless oxygen plasma etching process is investigated to nanopattern conjugated polymer, dodecylbenzenesulfonate-doped polypyrrole (PPy(DBS)), and to examine the effects of nanostructures on the inherent tunable wettability of the surface and the droplet mobility. Etching characteristics such as the geometry and dimension of the nanostructures are systematically examined for the etching power and duration. The mechanism of self-formation of vertically-aligned dense-array pillared nanostructures in the one-step maskless oxygen plasma etching process is also investigated...
June 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28605273/improving-the-prediction-of-maturity-from-anthropometric-variables-using-a-maturity-ratio
#11
Job Fransen, Stephen Bush, Stephen Woodcock, Andrew Novak, Dieter Deprez, Adam D G Baxter-Jones, Roel Vaeyens, Matthieu Lenoir
PURPOSE: This study aimed to improve the prediction accuracy of Age at Peak Height Velocity (APHV) from anthropometric assessment using non-linear models and a maturity ratio rather than a maturity offset. METHODS: The dataset used to develop the original prediction equations was used to test a new prediction model, utilising the maturity ratio and a polynomial prediction equation. This model was then applied to a sample of male youth academy soccer players (n = 1330) to validate the new model in youth athletes...
June 12, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28600490/treating-tobacco-dependence-guidance-for-primary-care-on-life-saving-interventions-position-statement-of-the-ipcrg
#12
O C P Van Schayck, S Williams, V Barchilon, N Baxter, M Jawad, P A Katsaounou, B J Kirenga, C Panaitescu, K W I G Tsiligianni, N Zwar, A Ostrem
Tobacco smoking is the world's leading cause of premature death and disability. Global targets to reduce premature deaths by 25% by 2025 will require a substantial increase in the number of smokers making a quit attempt, and a significant improvement in the success rates of those attempts in low, middle and high income countries. In many countries the only place where the majority of smokers can access support to quit is primary care. There is strong evidence of cost-effective interventions in primary care yet many opportunities to put these into practice are missed...
June 9, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28599556/acoustic-force-measurements-on-polymer-coated-microbubbles-in-a-microfluidic-device
#13
Gianluca Memoli, Christopher R Fury, Kate O Baxter, Pierre N Gélat, Philip H Jones
This work presents an acoustofluidic device for manipulating coated microbubbles, designed for the simultaneous use of optical and acoustical tweezers. A comprehensive characterization of the acoustic pressure in the device is presented, obtained by the synergic use of different techniques in the range of acoustic frequencies where visual observations showed aggregation of polymer-coated microbubbles. In absence of bubbles, the combined use of laser vibrometry and finite element modelling supported a non-invasive measurement of the acoustic pressure and an enhanced understanding of the system resonances...
May 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28595930/a-novel-hybrid-product-that-heats-tobacco-through-controlled-aerosol-release-part-2-in%C3%A2-vitro-biological-assessment-and-comparison-with-different-tobacco-heating-products
#14
Damien Breheny, Jason Adamson, David Azzopardi, Andrew Baxter, Emma Bishop, Tony Carr, Ian Crooks, Katherine Hewitt, Tomasz Jaunky, Sophie Larard, Frazer Lowe, Oluwatobiloba Oke, Mark Taylor, Simone Santopietro, David Thorne, Benjamin Zainuddin, Marianna Gaça, Chuan Liu, James Murphy, Christopher Proctor
This study assessed the toxicological and biological responses of aerosols from a novel hybrid tobacco product. Toxicological responses from the hybrid tobacco product were compared to those from a commercially available Tobacco Heating Product (c-THP), a prototype THP (p-THP) and a 3R4F reference cigarette, using in vitro test methods which were outlined as part of a framework to substantiate the risk reduction potential of novel tobacco and nicotine products. Exposure matrices used included total particulate matter (TPM), whole aerosol (WA), and aqueous aerosol extracts (AqE) obtained after machine-puffing the test products under the Health Canada Intense smoking regime...
May 30, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28594745/indications-for-contralateral-prophylactic-mastectomy-a-consensus-statement-using-modified-delphi-methodology
#15
Frances C Wright, Nicole J Look Hong, May Lynn Quan, Kaitlyn Beyfuss, Sara Temple, Andrea Covelli, Nancy Baxter, Anna R Gagliardi
OBJECTIVE: To reach a consensus about contralateral prophylactic mastectomy in unilateral breast cancer. SUMMARY BACKGROUND DATA: There has been a substantial increase in the number of North American women with unilateral breast cancer undergoing a therapeutic mastectomy and a contralateral prophylactic mastectomy (CPM) either simultaneously or sequentially. The purpose of this project was to create a nationally endorsed consensus statement for CPM in women with unilateral breast cancer using modified Delphi consensus methodology...
June 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28594586/differences-in-function-and-fracture-risk-in-postmenopausal-women-with-and-without-a-recent-distal-radius-fracture
#16
Katie L Crockett, Saija Kontulainen, Jon Farthing, Phil Chilibeck, Brenna Bath, Adam Baxter-Jones, Cathy Arnold
A distal radius fracture (DRF) is commonly the first fracture to occur in early postmenopausal women. The reasons for sustaining a DRF may be related to fall risk, bone fragility or both. The objective of this study was to compare functional and fracture risk status in postmenopausal women with and without a recent DRF and explore the relationships between function, grip strength and fracture risk status. METHODS: Seventy-seven women age 50-78 with (n=32) and without (n=45) a history of DRF in the past 2 years participated...
May 22, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28591587/nlrp6-protects-il10-mice-from-colitis-by-limiting-colonization-of-akkermansia-muciniphila
#17
Sergey S Seregin, Natasha Golovchenko, Bryan Schaf, Jiachen Chen, Nicholas A Pudlo, Jonathan Mitchell, Nielson T Baxter, Lili Zhao, Patrick D Schloss, Eric C Martens, Kathryn A Eaton, Grace Y Chen
No abstract text is available yet for this article.
June 6, 2017: Cell Reports
https://www.readbyqxmd.com/read/28588406/-formula-see-text-graded-discrete-lax-pairs-and-yang-baxter-maps
#18
Allan P Fordy, Pavlos Xenitidis
We recently introduced a class of [Formula: see text] graded discrete Lax pairs and studied the associated discrete integrable systems (lattice equations). In this paper, we introduce the corresponding Yang-Baxter maps. Many well-known examples belong to this scheme for N=2, so, for N≥3, our systems may be regarded as generalizations of these. In particular, for each N we introduce a class of multi-component Yang-Baxter maps, which include H(B)III (of Papageorgiou et al. 2010 SIGMA 6, 003 (9 p). (doi:10.3842/SIGMA...
May 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28588035/control-of-a-novel-spermatocyte-promoting-factor-by-the-male-germline-sex-determination-factor-phf7-of-drosophila-melanogaster
#19
Shu Yuan Yang, Yi-Chieh Chang, Yu Hsin Wan, Cale Whitworth, Ellen M Baxter, Shekerah Primus, Haiwei Pi, Mark Van Doren
A key aspect of germ cell development is to establish germline sexual identity and initiate a sex-specific developmental program to promote spermatogenesis or oogenesis. Previously, we have identified the histone reader Plant Homeodomain Finger 7 (PHF7) as an important regulator of male germline identity. To understand how PHF7 directs sexual differentiation of the male germline, we investigated the downstream targets of PHF7 by combining transcriptome analyses, which reveal genes regulated by Phf7, with genomic profiling of histone H3K4me2, the chromatin mark that is bound by PHF7...
June 6, 2017: Genetics
https://www.readbyqxmd.com/read/28585324/identification-of-major-loci-and-genomic-regions-controlling-acid-and-volatile-content-in-tomato-fruit-implications-for-flavor-improvement
#20
Guillaume Bauchet, Stéphane Grenier, Nicolas Samson, Vincent Segura, Aniko Kende, Jules Beekwilder, Katarina Cankar, Jean-Luc Gallois, Justine Gricourt, Julien Bonnet, Charles Baxter, Laurent Grivet, Mathilde Causse
Plant metabolites are important to world food security due to their roles in crop yield and nutritional quality. Here we report the metabolic profile of 300 tomato accessions (Solanum lycopersicum and related wild species) by quantifying 60 primary and secondary metabolites, including volatile organic compounds, over a period of 2 yr. Metabolite content and genetic inheritance of metabolites varied broadly, both within and between different genetic groups. Using genotype information gained from 10 000 single nucleotide polymorphism markers, we performed a metabolite genome-wide association mapping (GWAS) study...
June 6, 2017: New Phytologist
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