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https://www.readbyqxmd.com/read/28334820/high-resolution-time-course-mapping-of-early-transcriptomic-molecular-and-cellular-phenotypes-in-huntington-s-disease-cag-knock-in-mice-across-multiple-genetic-backgrounds
#1
Seth A Ament, Jocelynn R Pearl, Andrea Grindeland, Jason St Claire, John C Earls, Marina Kovalenko, Tammy Gillis, Jayalakshmi Mysore, James F Gusella, Jong-Min Lee, Seung Kwak, David Howland, Min Young Lee, David Baxter, Kelsey Scherler, Kai Wang, Donald Geman, Jeffrey B Carroll, Marcy E MacDonald, George Carlson, Vanessa C Wheeler, Nathan D Price, Leroy E Hood
Huntington's disease is a dominantly inherited neurodegenerative disease caused by the expansion of a CAG repeat in the HTT gene. In addition to the length of the CAG expansion, factors such as genetic background have been shown to contribute to the age at onset of neurological symptoms. A central challenge in understanding the disease progression that leads from the HD mutation to massive cell death in the striatum is the ability to characterize the subtle and early functional consequences of the CAG expansion longitudinally...
February 27, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28333171/dual-dimensional-nanostructures-with-highly-durable-non-wetting-properties-under-dynamic-and-underwater-conditions
#2
Seunghyeon Baek, Wuseok Kim, Sangmin Jeon, Kijung Yong
Non-wetting states with high durability under both dynamic and underwater conditions are very desirable for practical applications of superhydrophobic surfaces in various fields. Despite increasing demands for this dual stability of non-wetting surfaces, studies investigating both the impact dynamics and underwater stability are very rare. In the current study, we performed water droplet impact dynamics and underwater stability studies using ZnO/Si hierarchical nanostructures (HNs) as a model system. The effects of the surface structure on the non-wetting states under dynamic conditions were first studied by comparing various surface structures, such as ZnO nanowires (NWs), Si microposts (MPs), ZnO/Si HNs with controlled MP interspacings, and lotus leaf (LL)...
March 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28331886/effects-of-line-fiducial-parameters-and-beamforming-on-ultrasound-calibration
#3
Golafsoun Ameri, John S H Baxter, A Jonathan McLeod, Terry M Peters, Elvis C S Chen
Ultrasound (US)-guided interventions are often enhanced via integration with an augmented reality environment, a necessary component of which is US calibration. Calibration requires the segmentation of fiducials, i.e., a phantom, in US images. Fiducial localization error (FLE) can decrease US calibration accuracy, which fundamentally affects the total accuracy of the interventional guidance system. Here, we investigate the effects of US image reconstruction techniques as well as phantom material and geometry on US calibration...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28328384/the-surgeon-general-s-facing-addiction-report-an-historic-document-for-healthcare
#4
Sharon Levy, J Paul Seale, Victoria A Osborne, Kevin L Kraemer, Daniel P Alford, Jeffrey Baxter, Deborah S Finnell, Hillary Kunins, Alexander Y Walley, David C Lewis, Doreen MacLane-Baeder, Adam J Gordon
The publication of Facing Addiction in America: The Surgeon General's Report on Alcohol, Drugs, and Health presents an historic moment not only for the field of addiction medicine, but also for the United States as a nation. The Board of Directors of the Association for Medical Education and Research in Substance Abuse (AMERSA), on behalf of our organization, would like to express our appreciation of the efforts of Dr. Vivek Murthy and the Surgeon General's Office to publish the first surgeon general's report covering substance misuse and substance use disorders...
March 22, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28326351/effects-of-low-dose-ibuprofen-supplementation-and-resistance-training-on-bone-and-muscle-in-postmenopausal-women-a-randomized-controlled-trial
#5
Whitney R D Duff, Saija A Kontulainen, Darren G Candow, Julianne J Gordon, Riley S Mason, Regina Taylor-Gjevre, Bindu Nair, Michael Szafron, Adam D G Baxter-Jones, Gordon A Zello, Philip D Chilibeck
PURPOSE: To compare the effects of nine months of exercise training and ibuprofen supplementation (given immeditately after exercise sessions) on bone and muscle in postmenopausal women. METHODS: In a double-blind randomized trial, participants (females: n = 90, mean age 64.8, SD 4.3 years) were assigned (computer generated, double blind) to receive supervised resistance training or stretching 3 days/week, and ibuprofen (400 mg, post-exercise) or placebo (i...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28325351/flexible-fiber-optic-high-speed-imaging-of-vocal-fold-vibration-a-preliminary-report
#6
Peak Woo, Peter Baxter
OBJECTIVE: High-speed video (HSV) imaging of vocal fold vibration has been possible only through the rigid endoscope. This study reports that a fiberscope-based high-speed imaging system may allow HSV imaging of naturalistic voicing. MATERIALS AND METHODS: Twenty-two subjects were recorded using a commercially available black and white high-speed camera (Photron Motion Tools, 256 × 120 pixel, 2000 frames per second, 8 second acquisition time). The camera gain is set to +6 db...
March 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28320573/bleeding-related-complications-and-readmission-rates-associated-with-fibrin-sealant-use-in-patients-undergoing-coronary-artery-bypass-graft-surgery-in-the-united-states
#7
Yin Wan, Sangtaeck Lim, Xin Gao, Walter A Danker, Richard Kocharian, Gaurav Gangoli, Ashley P DeAnglis, James Hart
OBJECTIVES: To compare the clinical and economic outcomes of EVICEL (Ethicon, Inc., Somerville, NJ) and TISSEEL (Baxter Healthcare Corporation, Westlake Village, CA) use in patients undergoing primary coronary artery bypass graft (CABG) surgery. DESIGN: Retrospective database analysis. SETTING: Premier prospective hospital database (June 2009 through March 2014) covering approximately 20% of hospital discharges in the United States. PARTICIPANTS: Adults undergoing primary CABG surgery who received either EVICEL or TISSEEL on the day of surgery (index date)...
November 10, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28319694/sexual-trauma-is-more-strongly-associated-with-tonic-immobility-than-other-types-of-trauma-a-population-based-study
#8
Juliana Kalaf, Evandro Silva Freire Coutinho, Liliane Maria Pereira Vilete, Mariana Pires Luz, William Berger, Mauro Mendlowicz, Eliane Volchan, Sergio Baxter Andreoli, Maria Inês Quintana, Jair de Jesus Mari, Ivan Figueira
BACKGROUND: Tonic immobility is an involuntary motor and vocal inhibition reaction, considered the last-ditch response of the defensive cascade model. It is elicited in context of inescapable threat and perception of entrapment. Our aim was to investigate the association between different traumatic events and peritraumatic tonic immobility (PTI) in a representative sample of the general population. METHODS: This is a cross-sectional study of general population from Rio de Janeiro and São Paulo with 3231 victims of traumatic events aged 15-75 years who completed the Tonic Immobility Scale (TIS)...
March 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28303094/child-robot-interactions-for-second-language-tutoring-to-preschool-children
#9
Paul Vogt, Mirjam de Haas, Chiara de Jong, Peta Baxter, Emiel Krahmer
In this digital age social robots will increasingly be used for educational purposes, such as second language tutoring. In this perspective article, we propose a number of design features to develop a child-friendly social robot that can effectively support children in second language learning, and we discuss some technical challenges for developing these. The features we propose include choices to develop the robot such that it can act as a peer to motivate the child during second language learning and build trust at the same time, while still being more knowledgeable than the child and scaffolding that knowledge in adult-like manner...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28298142/effect-of-complete-syndesmotic-disruption-and-deltoid-injuries-and-different-reduction-methods-on-ankle-joint-contact-mechanics
#10
Jeremy LaMothe, Josh R Baxter, Susannah Gilbert, Conor I Murphy, Sydney C Karnovsky, Mark C Drakos
BACKGROUND: Syndesmotic injuries can be associated with poor patient outcomes and posttraumatic ankle arthritis, particularly in the case of malreduction. However, ankle joint contact mechanics following a syndesmotic injury and reduction remains poorly understood. The purpose of this study was to characterize the effects of a syndesmotic injury and reduction techniques on ankle joint contact mechanics in a biomechanical model. METHODS: Ten cadaveric whole lower leg specimens with undisturbed proximal tibiofibular joints were prepared and tested in this study...
March 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28297849/continuous-time-limits-of-the-utterance-selection-model
#11
Jérôme Michaud
In this paper we derive alternative continuous time limits of the utterance selection model (USM) for language change [G. J. Baxter et al., Phys. Rev. E 73, 046118 (2006)PLEEE81539-375510.1103/PhysRevE.73.046118]. This is motivated by the fact that the Fokker-Planck continuous time limit derived in the original version of the USM is only valid for a small range of parameters. We investigate the consequences of relaxing these constraints on parameters. Using the normal approximation of the multinomial approximation, we derive a continuous time limit of the USM in the form of a weak-noise stochastic differential equation...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28291808/foraging-and-metabolic-consequences-of-semi-anadromy-for-an-endangered-estuarine-fish
#12
Bruce G Hammock, Steven B Slater, Randall D Baxter, Nann A Fangue, Dennis Cocherell, April Hennessy, Tomofumi Kurobe, Christopher Y Tai, Swee J Teh
Diadromy affords fish access to productive ecosystems, increasing growth and ultimately fitness, but it is unclear whether these advantages persist for species migrating within highly altered habitat. Here, we compared the foraging success of wild Delta Smelt-an endangered, zooplanktivorous, annual, semi-anadromous fish that is endemic to the highly altered San Francisco Estuary (SFE)-collected from freshwater (<0.55 psu) and brackish habitat (≥0.55 psu). Stomach fullness, averaged across three generations of wild Delta Smelt sampled from juvenile through adult life stages (n = 1,318), was 1...
2017: PloS One
https://www.readbyqxmd.com/read/28291247/enhancing-studies-of-the-connectome-in-autism-using-the-autism-brain-imaging-data-exchange-ii
#13
Adriana Di Martino, David O'Connor, Bosi Chen, Kaat Alaerts, Jeffrey S Anderson, Michal Assaf, Joshua H Balsters, Leslie Baxter, Anita Beggiato, Sylvie Bernaerts, Laura M E Blanken, Susan Y Bookheimer, B Blair Braden, Lisa Byrge, F Xavier Castellanos, Mirella Dapretto, Richard Delorme, Damien A Fair, Inna Fishman, Jacqueline Fitzgerald, Louise Gallagher, R Joanne Jao Keehn, Daniel P Kennedy, Janet E Lainhart, Beatriz Luna, Stewart H Mostofsky, Ralph-Axel Müller, Mary Beth Nebel, Joel T Nigg, Kirsten O'Hearn, Marjorie Solomon, Roberto Toro, Chandan J Vaidya, Nicole Wenderoth, Tonya White, R Cameron Craddock, Catherine Lord, Bennett Leventhal, Michael P Milham
The second iteration of the Autism Brain Imaging Data Exchange (ABIDE II) aims to enhance the scope of brain connectomics research in Autism Spectrum Disorder (ASD). Consistent with the initial ABIDE effort (ABIDE I), that released 1112 datasets in 2012, this new multisite open-data resource is an aggregate of resting state functional magnetic resonance imaging (MRI) and corresponding structural MRI and phenotypic datasets. ABIDE II includes datasets from an additional 487 individuals with ASD and 557 controls previously collected across 16 international institutions...
March 14, 2017: Scientific Data
https://www.readbyqxmd.com/read/28288628/assessing-the-reporting-of-categorised-quantitative-variables-in-observational-epidemiological-studies
#14
Onkabetse V Mabikwa, Darren C Greenwood, Paul D Baxter, Sarah J Fleming
BACKGROUND: One aspect to consider when reporting results of observational studies in epidemiology is how quantitative risk factors are analysed. The STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines recommend that researchers describe how they handle quantitative variables when analysing data. For categorised quantitative variables, the authors are required to provide reasons and justifications informing their practice. We investigated and assessed the practices and reporting of categorised quantitative variables in epidemiology...
March 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28283553/genome-wide-association-study-of-sepsis-in-extremely-premature-infants
#15
Lakshmi Srinivasan, Grier Page, Haresh Kirpalani, Jeffrey C Murray, Abhik Das, Rosemary D Higgins, Waldemar A Carlo, Edward F Bell, Ronald N Goldberg, Kurt Schibler, Beena G Sood, David K Stevenson, Barbara J Stoll, Krisa P Van Meurs, Karen J Johnson, Joshua Levy, Scott A McDonald, Kristin M Zaterka-Baxter, Kathleen A Kennedy, Pablo J Sánchez, Shahnaz Duara, Michele C Walsh, Seetha Shankaran, James L Wynn, C Michael Cotten
OBJECTIVE: To identify genetic variants associated with sepsis (early-onset and late-onset) using a genome-wide association (GWA) analysis in a cohort of extremely premature infants. STUDY DESIGN: Previously generated GWA data from the Neonatal Research Network's anonymised genomic database biorepository of extremely premature infants were used for this study. Sepsis was defined as culture-positive early-onset or late-onset sepsis or culture-proven meningitis. Genomic and whole-genome-amplified DNA was genotyped for 1...
March 10, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28282774/cervical-length-in-adolescents-versus-adults
#16
Jessica N Buck, Kelly M Orzechowski, Jason K Baxter, Vincenzo Berghella
PURPOSE: Two of the known risk factors for spontaneous preterm birth (sPTB) are short cervical length (CL) ≤ 25 mm and adolescence (≤19 years). Our objective was to evaluate whether adolescent women have a higher incidence of short CL compared to their 20-24 year old counterparts. MATERIALS AND METHODS: Retrospective cohort of nulliparous singleton gestations undergoing universal second trimester transvaginal ultrasound (TVU) CL screening between January 2012 and June 2013...
February 28, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28270725/a-centrally-generated-primary-care-physician-audit-report-does-not-improve-colonoscopy-uptake-after-a-positive-result-on-a-fecal-occult-blood-test-in-ontario-s-coloncancercheck-program
#17
D Stock, L Rabeneck, N N Baxter, L F Paszat, R Sutradhar, L Yun, J Tinmouth
BACKGROUND: Timely follow-up of fecal occult blood screening with colonoscopy is essential for achieving colorectal cancer mortality reduction. In the present study, we evaluated the effectiveness of centrally generated, physician-targeted audit and feedback to improve colonoscopy uptake after a positive fecal occult blood test (fobt) result within Ontario's population-wide ColonCancerCheck Program. METHODS: This prospective cohort study used data sets from Ontario's ColonCancerCheck Program (2008-2011) that were linked to provincial administrative health databases...
February 2017: Current Oncology
https://www.readbyqxmd.com/read/28264927/missing-in-metastasis-protein-downregulates-cxcr4-by-promoting-ubiquitination-and-interaction-with-small-rab-gtpases
#18
Lushen Li, Shaneen S Baxter, Ning Gu, Min Ji, Xi Zhan
Surface expression of chemokine receptor CXCR4 is downregulated by MIM, a member of the inverse BAR (I-BAR) domain protein family that recognizes and generates membranes with negative curvatures. Yet, the mechanism for the regulation is unknown. Here, we showed that MIM formed a complex with CXCR4 via binding to E3 ubiquitin ligase AIP4 in response to SDF-1. Overexpression of MIM promoted CXCR4 ubiquitination, inhibited cellular response to SDF-1, caused accumulation and aggregation of MVBs in the cytoplasm, and promoted CXCR4 sorting into MVBs in a manner depending on binding to AIP4...
March 6, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28262984/diffusive-flux-of-pahs-across-sediment-water-and-water-air-interfaces-at-urban-superfund-sites
#19
D James Minick, Kim A Anderson
Superfund sites may be a source of polycyclic aromatic hydrocarbons (PAHs) to the surrounding environment. These sites can also act as PAH sinks from present day anthropogenic activities especially in urban locations. Understanding PAH transport across environmental compartments helps to define the relative contributions of these sources and is therefore important for informing remedial and management decisions. In the present study, paired passive samplers were co-deployed at sediment-water, and water-air interfaces within the Portland Harbor Superfund site (PHSS) and the McCormick and Baxter Superfund Site (MCBSS)...
March 6, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28259854/does-early-intervention-improve-outcomes-in-physiotherapy-management-of-lumbar-radicular-syndrome-a-mixed-methods-study-protocol
#20
Michael Reddington, Stephen J Walters, Judith Cohen, Susan Baxter
INTRODUCTION: Lumbar radicular syndrome (LRS) can be a painful and debilitating condition. The optimum management strategies and their timing remain elusive despite extensive research. Surgery provides good short-term outcomes but has concomitant risks and costs. Physiotherapy is commonly practised for patients with LRS but its effects remain equivocal and there is a lack of consensus on the type, duration and timing of physiotherapy intervention. There is a lack of high-quality evidence into new and innovative management strategies and the timings of those strategies for LRS...
March 3, 2017: BMJ Open
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