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https://www.readbyqxmd.com/read/28928214/fishing-out-the-hidden-enemy-advances-in-detecting-and-measuring-latent-hiv-infected-cells
#1
Vinayaka R Prasad, Ganjam V Kalpana
The indomitable aspect of HIV-1 infection is not that HIV-1 proviral DNA is integrated into host DNA but that it can also turn itself off, remaining invisible to drug or immune surveillance. Thus, the goals of eradication include ways to precisely excise HIV-1 DNA or wake up the silent HIV-1 provirus and eliminate the infected cells thus identified. Methods to identify and fish out the latently infected cells or to delineate their characteristics are being rapidly developed. In 2016, Baxter et al. (A. E. Baxter, J...
September 19, 2017: MBio
https://www.readbyqxmd.com/read/28925768/the-impact-of-long-term-systemic-glucocorticoid-use-in-severe-asthma-a-uk-retrospective-cohort-analysis
#2
Jonas Daugherty, Xiwu Lin, Richard Baxter, Robert Suruki, Eric Bradford
OBJECTIVE: Systemic glucocorticoids (SGCs) are a treatment option for severe asthma but are associated with the development of adverse events (AEs). Evidence on the extent of SGC use and the relationship between SGC dose and AE risk in severe asthma is limited. METHODS: Patients with severe asthma (Global Initiative for Asthma step 4/5), with no SGC use during the <6-12 months before severe asthma determination (index date) were identified in the UK-based Clinical Practice Research Datalink database (2004-2012)...
September 19, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28917536/birth-outcomes-following-immunization-of-pregnant-women-with-pandemic-h1n1-influenza-vaccine-2009-2010
#3
Abigail Eaton, Ned Lewis, Bruce Fireman, John Hansen, Roger Baxter, Julianne Gee, Nicola P Klein
BACKGROUND: Following the H1N1 influenza pandemic in 2009, pregnant women were recommended to receive both seasonal (TIV) and H1N1 influenza vaccines. This study presents incidence of adverse birth and pregnancy outcomes among a population of pregnant women immunized with TIV and H1N1 vaccines at Kaiser Permanente Northern California during 2009-2010. METHODS: We telephone surveyed pregnant Kaiser Permanente Northern California members to assess non-medically-attended reactions following H1N1, TIV or both vaccines during 2009-2010 (n=5365) in a separate study...
September 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28914750/live-attenuated-influenza-vaccination-prior-to-age-3-years-and-subsequent-development-of-asthma-a-14-year-follow-up-study
#4
Roger P Baxter, Ned Lewis, Bruce Fireman, John Hansen, Nicola P Klein, Justin R Ortiz
BACKGROUND: Live-attenuated influenza vaccines (LAIVs) are not licensed in children <2 years because of a wheezing safety signal that has not been fully elucidated. In 2000, the Kaiser Permanente Vaccine Study Center conducted a placebo controlled randomized clinical trial (RCT) of LAIV in children. As many of these children were still enrolled in Kaiser Permanente in 2014, we could assess the possible long-term association between LAIV and subsequent asthma diagnosis. METHODS: We identified all children who were originally enrolled into the LAIV RCT at < 3 years of age...
September 12, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28910796/modeling-of-internal-filtration-in-theranova-hemodialyzers
#5
Anna Lorenzin, Mauro Neri, William R Clark, Francesco Garzotto, Alessandra Brendolan, Federico Nalesso, Nicola Marchionna, Monica Zanella, Marco Sartori, Gianfranco B Fiore, Claudio Ronco
High retention onset (HRO) is the designation for a new class of hemodialysis membranes. A unique characteristic of this class is the highly selective and controlled porosity resulting in sieving properties that provide a clinically desirable balance between middle/large molecular weight solute removal and albumin loss. Another defining feature of this membrane class is the relatively small fiber diameter, which produces high convective volumes in the form of internal filtration. The aim of the present study was to estimate, by semi-empirical methods, convective volumes for 2 new HRO dialyzers: Theranova 400 and Theranova 500 (Baxter International Inc...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28904342/evolution-of-t-cell-responses-during-measles-virus-infection-and-rna-clearance
#6
Ashley N Nelson, Nicole Putnam, Debra Hauer, Victoria K Baxter, Robert J Adams, Diane E Griffin
Measles is an acute viral disease associated both with immune suppression and development of life-long immunity. Clearance of measles virus (MeV) involves rapid elimination of infectious virus during the rash followed by slow elimination of viral RNA. To characterize cellular immune responses during recovery, we analyzed the appearance, specificity and function of MeV-specific T cells for 6 months after respiratory infection of rhesus macaques with wild type MeV. IFN-γ and IL-17-producing cells specific for the hemagglutinin and nucleocapsid proteins appeared in circulation in multiple waves approximately 2-3, 8 and 18-24 weeks after infection...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28901657/longitudinal-patterns-in-bmi-and-percent-total-body-fat-from-peak-height-velocity-through-emerging-adulthood-into-young-adulthood
#7
Erin Barbour-Tuck, Marta Erlandson, Nazeem Muhajarine, Heather Foulds, Adam Baxter-Jones
OBJECTIVES: Emerging adulthood, a potential critical period, is an understudied period of fat mass accrual. The aim of this study was to describe patterns of fat mass accrual, and weight status, from adolescence, through emerging adulthood, into young adulthood. METHODS: One-hundred-eighteen participants (59 male) were measured repeatedly for 20 years. Annual measures of height, weight, and body composition (DXA) were taken. Calculated measures included: peak height velocity (PHV), biological age (BA; years from PHV), body mass index (BMI), and percent total body fat (%TBF)...
September 13, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28893281/rna-flow-cytometric-fish-for-investigations-into-hiv-immunology-vaccination-and-cure-strategies
#8
REVIEW
Amy E Baxter, Julia Niessl, Antigoni Morou, Daniel E Kaufmann
Despite the tremendous success of anti-retroviral therapy (ART) no current treatment can eradicate latent HIV reservoirs from HIV-infected individuals or generate, effective HIV-specific immunity. Technological limitations have hampered the identification and characterization of both HIV-infected cells and HIV-specific responses in clinical samples directly ex vivo. RNA-flow cytometric fluorescence in situ hybridisation (RNA Flow-FISH) is a powerful technique, which enables detection of mRNAs in conjunction with proteins at a single-cell level...
September 12, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28891911/delineating-the-trajectory-of-cognitive-recovery-from-general-anesthesia-in-older-adults-design-and-rationale-of-the-torie-trajectory-of-recovery-in-the-elderly-project
#9
Joshua S Mincer, Mark G Baxter, Patrick J McCormick, Mary Sano, Arthur E Schwartz, Jess W Brallier, Heather G Allore, Bradley N Delman, Margaret C Sewell, Prantik Kundu, Cheuk Ying Tang, Angela Sanchez, Stacie G Deiner
BACKGROUND: Mechanistic aspects of cognitive recovery after anesthesia and surgery are not yet well characterized, but may be vital to distinguishing the contributions of anesthesia and surgery in cognitive complications common in the elderly such as delirium and postoperative cognitive dysfunction. This article describes the aims and methodological approach to the ongoing study, Trajectory of Recovery in the Elderly (TORIE), which focuses on the trajectory of cognitive recovery from general anesthesia...
September 7, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28891555/corrigendum-synaptic-nmda-receptor-activity-is-coupled-to-the-transcriptional-control-of-the-glutathione-system
#10
Paul S Baxter, Karen F S Bell, Philip Hasel, Angela M Kaindl, Michael Fricker, Derek Thomson, Sean P Cregan, Thomas H Gillingwater, Giles E Hardingham
This corrects the article DOI: 10.1038/ncomms7761.
September 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28887297/defining-optimal-triage-strategies-for-hrhpv-screen-positive-women-an-evaluation-of-hpv-16-18-genotyping-cytology-and-p16-ki-67-cyto-immunochemistry
#11
Grazyna A Stanczuk, Gwen J Baxter, Heather Currie, William Forson, James R Lawrence, Kate Cuschieri, Allan Wilson, Lynne Patterson, Lynn Govan, Janice Black, Tim Palmer, Marc Arbyn
BACKGROUND: Several options for the triage of high-risk HPV screen positive (hrHPV+) women were assessed. METHODS: This study incorporated CIN2+ cases and controls, all of whom tested hrHPV+ and whose results of liquid-based cytology (LBC), HPV16/18 genotyping and p16/Ki67 cyto-immunochemistry were available. Sensitivity and specificity for the CIN2+ of these triage tests were evaluated. RESULTS: Absolute sensitivities of HPV 16/18 typing, LBC and p16/Ki-67 cyto-immunochemistry for CIN2+ detection were 61...
September 8, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28885565/tracking-dietary-patterns-over-20-years-from-childhood-through-adolescence-into-young-adulthood-the-saskatchewan-pediatric-bone-mineral-accrual-study
#12
Elham Z Movassagh, Adam D G Baxter-Jones, Saija Kontulainen, Susan J Whiting, Hassanali Vatanparast
Dietary patterns established during adolescence might play a role in adulthood disease. We examined the stability of dietary patterns (DPs) from childhood through adolescence and into young adulthood (from age 8 to 34 years). Data from 130 participants (53 females) of Saskatchewan Pediatric Bone Mineral Accrual Study (aged 8-15 years, at baseline) were included. Multiple 24-h recalls were collected annually from 1991 to 1997, 2002 to 2005, and 2010 and 2011. Using principal component analysis, "Vegetarian-style", "Western-like", "High-fat, high-protein", "Mixed", and "Snack" DPs were derived at baseline...
September 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28880280/multiparametric-characterization-of-rare-hiv-infected-cells-using-an-rna-flow-fish-technique
#13
Amy E Baxter, Julia Niessl, Rémi Fromentin, Jonathan Richard, Filippos Porichis, Marta Massanella, Nathalie Brassard, Nirmin Alsahafi, Jean-Pierre Routy, Andrés Finzi, Nicolas Chomont, Daniel E Kaufmann
Efforts to cure HIV are hampered by limited characterization of the cells supporting HIV replication in vivo and inadequate methods for quantifying the latent viral reservoir in individuals receiving antiretroviral therapy (ART). We describe a protocol for flow cytometric identification of viral reservoirs, based on concurrent detection of cellular HIV Gagpol mRNA by in situ RNA hybridization combined with antibody staining for the HIV Gag protein. By simultaneously detecting both HIV RNA and protein, the CD4 T cells harboring translation-competent virus can be identified...
October 2017: Nature Protocols
https://www.readbyqxmd.com/read/28880076/exploiting-overlapping-advantages-of-in-vitro-and-in-cellulo-selection-systems-to-isolate-a-novel-high-affinity-cjun-antagonist
#14
Daniel Baxter, Christopher G Ullman, Laura Frigotto, Jody M Mason
We have combined two peptide library-screening systems, exploiting the benefits offered by both to select novel antagonistic agents of cJun. CIS display is an in vitro cell-free system that allows very large libraries (≤10(14)) to be interrogated. However, affinity-based screening conditions can poorly reflect those relevant to therapeutic application, particularly for difficult intracellular targets, and can lead to false positives. In contrast, an in cellulo screening system such as the Protein-fragment Complementation Assay (PCA) selects peptides with high target affinity while additionally profiling for target specificity, protease resistance, solubility, and lack of toxicity in a more relevant context...
September 7, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28877699/honoring-the-voices-of-bereaved-caregivers-a-metasummary-of-qualitative-research
#15
Lorraine Holtslander, Sharon Baxter, Kelly Mills, Sarah Bocking, Tina Dadgostari, Wendy Duggleby, Vicky Duncan, Peter Hudson, Agatha Ogunkorode, Shelley Peacock
BACKGROUND: Family caregiving in the context of advanced disease in particular, can be physically and emotionally taxing. Caregivers can subsequently face bereavement exhausted with few supports, limited resources and a significant proportion will develop negative psychological and social outcomes. Although some research has attended to the bereavement experiences of family caregivers who had cared for a person requiring palliative care, a comprehensive qualitative understanding of the impact of caregiving on bereavement has not been articulated...
September 6, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28875812/nurses-just-need-decent-pay
#16
Martin Baxter
In the 1980s, London hospitals had nurses' accommodation at a minimal rent (Readers panel, 23 August).
September 6, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28874667/erratum-treating-tobacco-dependence-guidance-for-primary-care-on-life-saving-interventions-position-statement-of-the-ipcrg
#17
O C P Van Schayck, S Williams, V Barchilon, N Baxter, M Jawad, P A Katsaounou, B J Kirenga, C Panaitescu, I G Tsiligianni, N Zwar, A Ostrem
A correction to this article has been published and is linked from the HTML version of this article.
September 5, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28867291/cancer-recurrence-after-solid-organ-transplantation-a-systematic-review-and-meta-analysis
#18
REVIEW
Sergio A Acuna, Johnny W Huang, Fahima Dossa, Prakesh S Shah, S Joseph Kim, Nancy N Baxter
Solid organ transplant recipients (SOTR) with a pre-transplant malignancy (PTM) have been thought to be at high risk of cancer recurrence. However, recent population-based studies report cancer recurrence rates in SOTR similar to those of non-transplant patients. A systematic search was performed in MEDLINE, EMBASE, and Cochrane Library to identify studies reporting cancer recurrence in SOTR with PTM. Quality assessment was performed using a validated tool for assessing the quality of an observational study with no control group designed by the Institute of Health Economics...
August 10, 2017: Transplantation Reviews
https://www.readbyqxmd.com/read/28866776/-1-h-15-n-13-c-backbone-resonance-assignments-of-human-phosphoglycerate-kinase-in-a-transition-state-analogue-complex-with-adp-3-phosphoglycerate-and-magnesium-trifluoride
#19
Zhalgas Serimbetov, Nicola J Baxter, Matthew J Cliff, Jonathan P Waltho
Human phosphoglycerate kinase (PGK) is an energy generating glycolytic enzyme that catalyses the transfer of a phosphoryl group from 1,3-bisphosphoglycerate (BPG) to ADP producing 3-phosphoglycerate (3PG) and ATP. PGK is composed of two α/β Rossmann-fold domains linked by a central α-helix and the active site is located in the cleft formed between the N-domain which binds BPG or 3PG, and the C-domain which binds the nucleotides ADP or ATP. Domain closure is required to bring the two substrates into close proximity for phosphoryl transfer to occur, however previous structural studies involving a range of native substrates and substrate analogues only yielded open or partly closed PGK complexes...
September 2, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28863319/comparison-of-mechanical-compressive-properties-of-commercial-and-autologous-fibrin-glues-for-tissue-engineering-applications
#20
Matthew G Cravens, Anthony W Behn, Jason L Dragoo
BACKGROUND: Fibrin glues are widely used in orthopedic surgery as adhesives and hemostatic agents. We evaluated the compressive properties of selected fibrin glues in order to identify which are appropriate for tissue regeneration applications subject to compression. METHODS: Uniaxial unconfined compression tests were performed on fibrin gels prepared from commercial and autologous products: (1) Evicel (Ethicon), (2) Tisseel (Baxter), (3) Angel (Arthrex), and (4) ProPlaz (Biorich)...
August 23, 2017: Clinical Biomechanics
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