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https://www.readbyqxmd.com/read/27919700/exposure-to-sevoflurane-anesthesia-during-development-does-not-impair-aspects-of-attention-during-adulthood-in-rats
#1
Kathy L Murphy, Jill McGaughy, Paula L Croxson, Mark G Baxter
Exposure to general anesthetic agents during development has been associated with neurotoxicity and long-term behavioral impairments in rodents and non-human primates. The phenotype of anesthetic-induced cognitive impairment has a robust learning and memory component, however less is known about other psychological domains. Data from retrospective human patient studies suggest that children undergoing multiple procedures requiring general anesthesia are at increased risk of attention deficit hyperactivity disorder...
December 2, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27918277/computational-model-of-a-positive-bdnf-feedback-loop-in-hippocampal-neurons-following-inhibitory-avoidance-training
#2
Yili Zhang, Paul Smolen, Cristina M Alberini, Douglas A Baxter, John H Byrne
Inhibitory avoidance (IA) training in rodents initiates a molecular cascade within hippocampal neurons. This cascade contributes to the transition of short- to long-term memory (i.e., consolidation). Here, a differential equation-based model was developed to describe a positive feedback loop within this molecular cascade. The feedback loop begins with an IA-induced release of brain-derived neurotrophic factor (BDNF), which in turn leads to rapid phosphorylation of the cAMP response element-binding protein (pCREB), and a subsequent increase in the level of the β isoform of the CCAAT/enhancer binding protein (C/EBPβ)...
December 2016: Learning & Memory
https://www.readbyqxmd.com/read/27917757/the-dual-burden-of-gender-based-violence-and-hiv-in-adolescent-girls-and-young-women-in-south-africa
#3
Q Abdool Karim, C Baxter
No abstract text is available yet for this article.
December 1, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27916687/a-unique-combination-of-micronutrients-rejuvenates-cognitive-performance-in-aged-mice
#4
Sam D Perez, Kristy Du, Catarina Rendeiro, Lin Wang, Qian Wu, Stanislav S Rubakhin, Rema Vazhappilly, Jeffrey H Baxter, Jonathan V Sweedler, Justin S Rhodes
It is widely believed that diet can influence the onset and severity of cognitive aging, but the optimal combination of micronutrients and molecular and cellular mechanisms remain elusive. The purpose of this study was to compare the effects of eight distinct diets, consisting of various concentrations of selected micronutrients, on learning and memory as well as markers of neuronal plasticity, and metabolic and neuro-immune status of the aged hippocampus. Eighteen-month-old male and female C57BL/6J mice were fed the diets for 16 weeks, followed by learning and memory trials on the active avoidance task...
December 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27914919/expressing-a-moth-abcc2-gene-in-transgenic-drosophila-causes-susceptibility-to-bt-cry1ac-without-requiring-a-cadherin-like-protein-receptor
#5
Tristan Stevens, Sisi Song, John B Bruning, Amanda Choo, Simon W Baxter
Bt toxins ingested by insect pests can bind to midgut receptors and cause death, although several steps in this process remain unclear. Multiple Bt toxin receptors have been identified in Lepidoptera, including a cadherin-like protein (CaLP), which is central to several models explaining Bt toxins' mode of action. Mutations in the Plutella xylostella ATP-dependent binding cassette transporter C2 (Px-abcc2), rather than CaLP, are genetically linked with Bt Cry1Ac resistance. Here we expressed Px-abcc2 in Drosophila and performed larval bioassays to determine whether this protein acts as an effective Bt receptor...
November 30, 2016: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27914874/transmission-networks-and-risk-of-hiv-infection-in-kwazulu-natal-south-africa-a-community-wide-phylogenetic-study
#6
Tulio de Oliveira, Ayesha B M Kharsany, Tiago Gräf, Cherie Cawood, David Khanyile, Anneke Grobler, Adrian Puren, Savathree Madurai, Cheryl Baxter, Quarraisha Abdool Karim, Salim S Abdool Karim
BACKGROUND: The incidence of HIV infection in young women in Africa is very high. We did a large-scale community-wide phylogenetic study to examine the underlying HIV transmission dynamics and the source and consequences of high rates of HIV infection in young women in South Africa. METHODS: We did a cross-sectional household survey of randomly selected individuals aged 15-49 years in two neighbouring subdistricts (one urban and one rural) with a high burden of HIV infection in KwaZulu-Natal, South Africa...
November 30, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27912252/impact-of-stretching-on-the-performance-and-injury-risk-of-long-distance-runners
#7
Claire Baxter, Lars R Mc Naughton, Andy Sparks, Lynda Norton, David Bentley
Stretching, either prior to exercise or at the end, or both, is typically carried out by all individuals undertaking sporting activity whether they be elite or recreational athletes. The many forms of stretching available to the athlete, either passive or active, have long been thought to improve performance, decrease injury and generally be advantageous to the athlete. This review examines the current state of the literature and evaluates what athletes can and should do with respect to this controversial topic...
December 2, 2016: Research in Sports Medicine
https://www.readbyqxmd.com/read/27905017/an-evaluation-of-preparedness-delivery-and-impact-of-surgical-and-anesthesia-care-in-madagascar-a-framework-for-a-national-surgical-plan
#8
Emily Bruno, Michelle C White, Linden S Baxter, Vaonandianina Agnès Ravelojaona, Hasiniaina Narindria Rakotoarison, Hery Harimanitra Andriamanjato, Kristin L Close, Alison Herbert, Nakul Raykar, Saurabh Saluja, Mark G Shrime
BACKGROUND: The Lancet Commission on Global Surgery (LCoGS) described the lack of access to safe, affordable, timely surgical, and anesthesia care. It proposed a series of 6 indicators to measure surgery, accompanied by time-bound targets and a template for national surgical planning. To date, no sub-Saharan African country has completed and published a nationwide evaluation of its surgical system within this framework. METHOD: Mercy Ships, in partnership with Harvard Medical School and the Madagascar Ministry of Health, collected data on the 6 indicators from 22 referral hospitals in 16 out of 22 regions of Madagascar...
November 30, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27897194/wetting-theory-for-small-droplets-on-textured-solid-surfaces
#9
Donggyu Kim, Nicola M Pugno, Seunghwa Ryu
Conventional wetting theories on rough surfaces with Wenzel, Cassie-Baxter, and Penetrate modes suggest the possibility of tuning the contact angle by adjusting the surface texture. Despite decades of intensive study, there are still many experimental results that are not well understood because conventional wetting theory, which assumes an infinite droplet size, has been used to explain measurements of finite-sized droplets. Here, we suggest a wetting theory applicable to a wide range of droplet size for the three wetting modes by analyzing the free energy landscape with many local minima originated from the finite size...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27884187/a-simulation-study-to-quantify-the-impacts-of-exposure-measurement-error-on-air-pollution-health-risk-estimates-in-copollutant-time-series-models
#10
Kathie L Dionisio, Howard H Chang, Lisa K Baxter
BACKGROUND: Exposure measurement error in copollutant epidemiologic models has the potential to introduce bias in relative risk (RR) estimates. A simulation study was conducted using empirical data to quantify the impact of correlated measurement errors in time-series analyses of air pollution and health. METHODS: ZIP-code level estimates of exposure for six pollutants (CO, NOx, EC, PM2.5, SO4, O3) from 1999 to 2002 in the Atlanta metropolitan area were used to calculate spatial, population (i...
November 25, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27880019/inferential-and-forward-projection-modeling-to-evaluate-options-for-controlling-invasive-mammals-on-islands
#11
D P Anderson, P McMurtrie, K-A Edge, P W J Baxter, A E Byrom
Successful pest-mammal eradications from remote islands have resulted in important biodiversity benefits. Near-shore islands can also serve as refuges for native biota but require ongoing effort to maintain low-pest or pest-free status. Three management options are available in the presence of reinvasion risk: (1) control-to-zero density, in which immigration may occur but reinvaders are removed; (2) sustained population suppression (to relatively low numbers); or (3) no action. Biodiversity benefits can result from options one and two...
December 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27876692/methods-for-broadband-spectral-analysis-intrinsic-fluorescence-temperature-sensing-as-an-example
#12
Weiwei Zhang, Guoyao Wang, Greg W Baxter, Stephen F Collins
A systematic study was performed on the temperature-dependent fluorescence of (Ba,Sr)2SiO4:Eu(2+) The barycenter and extended intensity ratio techniques were proposed to characterize the broadband fluorescence spectra. These techniques and other known methods (listed below) were employed and compared in the fluorescent temperature sensing experiment. Multiple sensing functions were obtained using the behaviors of: (1) the barycenter location of the emission band; (2) the emission bandwidth; and (3) the ratio of intensities at different wavelengths in the emission band, respectively...
November 22, 2016: Applied Spectroscopy
https://www.readbyqxmd.com/read/27875501/effects-of-ibuprofen-and-resistance-training-on-bone-and-muscle-an-rct-in-older-women
#13
Whitney R D Duff, Philip D Chilibeck, Darren G Candow, Julianne J Gordon, Riley S Mason, Regina Taylor-Gjevre, Bindu Nair, Michael Szafron, Adam Baxter-Jones, Gordon A Zello, Saija A Kontulainen
INTRODUCTION/PURPOSE: Resistance training with ibuprofen supplementation may improve musculoskeletal health in postmenopausal women. The study purpose was to determine the efficacy of resistance training and ibuprofen supplementation on bone and muscle properties in postmenopausal women. METHODS: Participants (n = 90, 65.3 ± 4.9 y) were randomly assigned to: supervised resistance training or stretching (placebo-exercise) with post-exercise ibuprofen (400 mg) or placebo supplementation for 3 days/week (9 months)...
November 21, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27869972/effectiveness-of-psychosocial-care-in-school-continuity-of-adolescents-in-social-vulnerability
#14
Tassiane Cristine Santos de Paula, Fernanda Gonçalves Moreira, Sérgio Baxter Andreoli
OBJECTIVE: to study the effectiveness of a psychosocial care program in school continuity of adolescents in social vulnerability. METHODS: this was a retrospective cohort study involving 200 adolescents assisted in a multidisciplinary intervention program with harm reduction approach, from 2007 to 2012; the intervention effect was assessed using Poisson regression models. RESULTS: 200 adolescents were included in the program; 116 of them continued and 84 dropped it; 74...
October 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27862902/cardiovascular-events-and-all-cause-mortality-associated-with-sulfonylureas-compared-to-other-antihyperglycaemic-drugs-a-bayesian-meta-analysis-of-survival-data
#15
Steve Bain, Eric Druyts, Chakrapani Balijepalli, Carl A Baxter, Craig Currie, Romita Das, Richard Donnelly, Kamlesh Khunti, Haya Langerman, Paul Leigh, Gaye Siliman, Kristian Thorlund, Kabirraaj Toor, Jiten Vora, Edward J Mills
AIM: Our aim was to conduct a systematic review and meta-analysis to determine the risk of cardiovascular events and all-cause mortality associated with sulfonylureas versus other antihyperglycaemic drugs in patients with type 2 diabetes. MATERIALS AND METHODS: A systematic review of Medline, Embase, Cochrane, and clinicaltrials.gov was conducted comparing sulfonylurea to placebo or other antihyperglycaemic drugs in patients with type 2 diabetes. A cloglog model was employed in the Bayesian framework to obtain comparative hazard ratios between interventions...
November 14, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27862852/transgenic-switchgrass-panicum-virgatum-l-targeted-for-reduced-recalcitrance-to-bioconversion-a-two-year-comparative-analysis-of-field-grown-lines-modified-for-target-gene-or-genetic-element-expression
#16
Alexandru Dumitrache, Jace Natzke, Miguel Rodriguez, Kelsey L Yee, Olivia A Thompson, Charleson R Poovaiah, Hui Shen, Mitra Mazarei, Holly L Baxter, Chunxiang Fu, Zeng-Yu Wang, Ajaya K Biswal, Guifen Li, Yuhong Tang, C Neal Stewart, Richard A Dixon, Richard S Nelson, Debra Mohnen, Jonathan Mielenz, Steven D Brown, Brian H Davison
Transgenic Panicum virgatum L. silencing (KD) or over-expressing (OE) specific genes or a small RNA (GAUT4-KD, miRNA156-OE, MYB4-OE, COMT-KD and FPGS-KD) were grown in the field and aerial tissue analyzed for biofuel production traits. Clones representing independent transgenic lines were established and senesced tissue sampled after year one and two growth cycles. Biomass was analyzed for wall sugars, recalcitrance to enzymatic digestibility, and biofuel production using separate hydrolysis and fermentation (SHF)...
November 18, 2016: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/27842559/dna-from-fecal-immunochemical-test-can-replace-stool-for-detection-of-colonic-lesions-using-a-microbiota-based-model
#17
Nielson T Baxter, Charles C Koumpouras, Mary A M Rogers, Mack T Ruffin, Patrick D Schloss
BACKGROUND: There is a significant demand for colorectal cancer (CRC) screening methods that are noninvasive, inexpensive, and capable of accurately detecting early stage tumors. It has been shown that models based on the gut microbiota can complement the fecal occult blood test and fecal immunochemical test (FIT). However, a barrier to microbiota-based screening is the need to collect and store a patient's stool sample. RESULTS: Using stool samples collected from 404 patients, we tested whether the residual buffer containing resuspended feces in FIT cartridges could be used in place of intact stool samples...
November 14, 2016: Microbiome
https://www.readbyqxmd.com/read/27836105/editorial
#18
EDITORIAL
G Baxter
No abstract text is available yet for this article.
November 8, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27835613/efficacy-and-safety-of-tenofovir-containing-antiretroviral-therapy-in-women-who-acquired-hiv-while-enrolled-in-tenofovir-gel-prophylaxis-trials
#19
Nivashnee Naicker, Anushka Naidoo, Lise Werner, Nigel Garrett, Nelisile Majola, Villeshni Asari, Cheryl Baxter, Anneke Grobler, Quarraisha Abdool Karim, Salim S Abdool Karim
BACKGROUND: We assessed whether women who acquired HIV during tenofovir gel prophylaxis trials can be safely and effectively treated with tenofovir-containing antiretroviral therapy (ART). METHODS: Between May 2011 and October 2014, HIV seroconvertors from two tenofovir gel trials were recruited when eligible for ART (CD4 count <350 cells/μl, pregnancy or AIDS-defining illness). Women were randomised to tenofovir-containing (tenofovir + lamivudine/emtricitabine + efavirenz) or tenofovir-sparing (zidovudine + lamivudine/emtricitabine + efavirenz) antiretroviral treatment regimens...
November 4, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27834743/infarct-in-a-new-territory-after-treatment-administration-in-the-escape-randomized-controlled-trial-endovascular-treatment-for-small-core-and-anterior-circulation-proximal-occlusion-with-emphasis-on-minimizing-ct-to-recanalization-times
#20
Aravind Ganesh, Fahad S Al-Ajlan, Farahna Sabiq, Zarina Assis, Jeremy L Rempel, Kenneth Butcher, John Thornton, Peter Kelly, Daniel Roy, Alexandre Y Poppe, Tudor G Jovin, Thomas Devlin, Blaise W Baxter, Timo Krings, Leanne K Casaubon, Donald F Frei, Hana Choe, Donatella Tampieri, Jeanne Teitelbaum, Cheemun Lum, Jennifer Mandzia, Stephen J Phillips, Oh Young Bang, Mohammed A Almekhlafi, Shelagh B Coutts, Philip A Barber, Tolulope Sajobi, Andrew M Demchuk, Muneer Eesa, Michael D Hill, Mayank Goyal, Bijoy K Menon
BACKGROUND AND PURPOSE: Infarct in a new previously unaffected territory (INT) is a potential complication of endovascular treatment. We applied a recently proposed methodology to identify and classify INTs in the ESCAPE randomized controlled trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times). METHODS: The core laboratory identified INTs on 24-hour follow-up imaging, blinded to treatment allocation, after assessing all baseline imaging...
December 2016: Stroke; a Journal of Cerebral Circulation
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