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https://www.readbyqxmd.com/read/28212447/diffuse-large-b-cell-lymphoma-with-concurrent-high-myc-and-bcl2-expression-shows-evidence-of-active-b-cell-receptor-signaling-by-quantitative-immunofluorescence
#1
Agata M Bogusz, Alexandra E Kovach, Long P Le, Derek Feng, Richard H G Baxter, Aliyah R Sohani
B-cell receptor (BCR)-mediated signaling plays an important role in the pathogenesis of a subset of diffuse large B-cell lymphoma (DLBCL), and novel agents targeting this pathway are now in clinical use. We have previously identified a signature of active BCR signaling on formalin-fixed paraffin-embedded specimens using quantitative immunofluorescence, allowing for identification of patients who might benefit from anti-BCR therapies. We sought to characterize the clinicopathologic significance of active BCR signaling in DLBCL by correlating measures of signaling intensity with clinical features and various tumor cell characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28208359/critical-behavior-of-the-spin-1-and-spin-3-2-baxter-wu-model-in-a-crystal-field
#2
D A Dias, J C Xavier, J A Plascak
The phase diagram and the critical behavior of the spin-1 and the spin-3/2 two-dimensional Baxter-Wu model in a crystal field are studied by conventional finite-size scaling and conformal invariance theory. The phase diagram of this model, for the spin-1 case, is qualitatively the same as those of the diluted 4-states Potts model and the spin-1 Blume-Capel model. However, for the present case, instead of a tricritical point one has a pentacritical point for a finite value of the crystal field, in disagreement with previous work based on finite-size calculations...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28202939/from-initial-nucleation-to-cassie-baxter-state-of-condensed-droplets-on-nanotextured-superhydrophobic-surfaces
#3
Cunjing Lv, Xiwen Zhang, Fenglei Niu, Feng He, Pengfei Hao
Understanding how droplet condensation happens plays an essential role for our fundamental insights of wetting behaviors in nature and numerous applications. Since there is a lack of study of the initial formation and growing processes of condensed droplets down to nano-/submicroscale, relevant underlying mechanisms remain to be explored. We report an in situ observation of vapor condensation on nano-/microtextured superhydrophobic surfaces using optical microscopy. An interesting picture of the vapor condensation, from the initial appearance of individual small droplets (≤1 μm) to a Cassie-Baxter wetting state (>30 μm), are exhibited...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197555/biphasic-regulation-of-p38-mapk-by-serotonin-contributes-to-the-efficacy-of-stimulus-protocols-that-induce-long-term-synaptic-facilitation
#4
Yili Zhang, Paul Smolen, Douglas A Baxter, John H Byrne
The MAPK isoforms ERK and p38 MAPK are believed to play opposing roles in long-term synaptic facilitation (LTF) induced by serotonin (5-HT) in Aplysia. To fully understand their roles, however, it is necessary to consider the dynamics of ERK and p38 MAPK activation. Previous studies determined that activation of ERK occurred ∼45 min after a 5-min pulse of 5-HT treatment. The dynamics of p38 MAPK activation following 5-HT are yet to be elucidated. Here, the activity of p38 MAPK was examined at different times after 5-HT, and the interaction between the ERK and p38 MAPK pathways was investigated...
January 2017: ENeuro
https://www.readbyqxmd.com/read/28196457/dermal-absorption-of-fumigant-gases-during-hazmat-incident-exposure-scenarios-methyl-bromide-sulfuryl-fluoride-and-chloropicrin
#5
Sharyn Gaskin, Linda Heath, Dino Pisaniello, John W Edwards, Michael Logan, Christina Baxter
Accidental or intentional releases of toxic gases or vapors are the most common occurrence in hazardous material (HAZMAT) incidents that result in human injuries. The most serious hazard from exposure to gases or vapors is via the respiratory system. Dermal uptake, as a secondary route, is still a concern, most acutely for the unprotected public. There is a limited evidence base describing skin absorption of toxic gases and vapors in HAZMAT exposure scenarios, which are relatively brief compared with traditional test periods for skin absorption studies...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28183625/the-design-of-superhydrophobic-stainless-steel-surfaces-by-controlling-nanostructures-a-key-parameter-to-reduce-the-implantation-of-pathogenic-bacteria
#6
Jérôme Bruzaud, Jeanne Tarrade, Elena Celia, Thierry Darmanin, Elisabeth Taffin de Givenchy, Frédéric Guittard, Jean-Marie Herry, Morgan Guilbaud, Marie-Noëlle Bellon-Fontaine
Reducing bacterial adhesion on substrates is fundamental for various industries. In this work, new superhydrophobic surfaces are created by electrodeposition of hydrophobic polymers (PEDOT-F4 or PEDOT-H8) on stainless steel with controlled topographical features, especially at a nano-scale. Results show that anti-bioadhesive and anti-biofilm properties require the control of the surface topographical features, and should be associated with a low adhesion of water onto the surface (Cassie-Baxter state) with limited crevice features at the scale of bacterial cells (nano-scale structures)...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28181642/cognitive-decline-and-the-ppar-%C3%AE-pro12ala-genotype-variation-by-sex-and-ethnicity
#7
Nancy A West, Judith Baxter, Lucinda L Bryant, Tracy L Nelson
No abstract text is available yet for this article.
January 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28179997/the-plant-defensin-nad1-induces-tumor-cell-death-via-a-non-apoptotic-membranolytic-process
#8
Amy A Baxter, Ivan Kh Poon, Mark D Hulett
Cationic anti-microbial peptides (CAPs) have an important role in host innate defense against pathogens such as bacteria and fungi. Many CAPs including defensins also exhibit selective cytotoxic activity towards mammalian cells via both apoptotic and non-apoptotic processes, and are being investigated as potential anticancer agents. The anti-fungal plant defensin from ornamental tobacco, Nicotiana alata Defensin 1 (NaD1), was recently shown to induce necrotic-like cell death in a number of tumor cell types within 30 min of treatment, at a concentration of 10 μM...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179721/professional-identity-formation-in-an-advanced-pharmacy-practice-experience-emphasizing-self-authorship
#9
Jessica L Johnson, Sheila Chauvin
Objective. To examine the extent to which reflective essays written by graduating pharmacy students revealed professional identity formation and self-authorship development. Design. Following a six-week advanced pharmacy practice experience (APPE) grounded in Baxter-Magolda's Learning Partnerships Model of self-authorship development, students completed a culminating reflective essay on their rotation experiences and professional identity formation. Assessment. Thematic and categorical analysis of 41 de-identified essays revealed nine themes and evidence of all Baxter-Magolda's domains and phases of self-authorship...
December 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28174038/fourth-grade-children-s-dietary-reporting-accuracy-by-meal-component-results-from-a-validation-study-that-manipulated-retention-interval-and-prompts
#10
Suzanne D Baxter, David B Hitchcock, Julie A Royer, Albert F Smith, Caroline H Guinn
We examined reporting accuracy by meal component (beverage, bread, breakfast meat, combination entrée, condiment, dessert, entrée, fruit, vegetable) with validation-study data on 455 fourth-grade children (mean age = 9.92 ± 0.41 years) observed eating school meals and randomized to one of eight dietary recall conditions (two retention intervals [short, long] crossed with four prompts [forward, meal-name, open, reverse]). Accuracy category (match [observed and reported], omission [observed but unreported], intrusion [unobserved but reported]) was a polytomous nominal item response variable...
February 4, 2017: Appetite
https://www.readbyqxmd.com/read/28169568/the-influence-of-age-sex-and-body-mass-index-on-the-effectiveness-of-brisk-walking-for-obesity-management-in-adults-a-systematic-review-and-meta-analysis
#11
Leon Mabire, Ramakrishnan Mani, Lizhou Liu, Hilda Mulligan, David Baxter
BACKGROUND: Brisk walking is the most popular activity for obesity management for adults. We aimed to identify whether participant age, sex and body mass index (BMI) influenced the effectiveness of brisk walking. METHODS: A search of nine databases was conducted for randomized controlled trials (RCTs). Two investigators selected RCTs reporting on change in body weight, BMI, waist circumference, fat mass, fat-free mass, and body fat percentage following a brisk walking intervention in obese adults...
February 7, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28168807/hypoxia-induced-hif1%C3%AE-targets-in-melanocytes-reveal-a-molecular-profile-associated-with-poor-melanoma-prognosis
#12
Stacie K Loftus, Laura L Baxter, Julia C Cronin, Temesgen D Fufa, William J Pavan
Hypoxia and HIF1α signaling direct tissue-specific gene responses regulating tumor progression, invasion and metastasis. By integrating HIF1α knockdown and hypoxia-induced gene expression changes, this study identifies a melanocyte-specific, HIF1α-dependent / hypoxia-responsive gene expression signature. Integration of these gene expression changes with HIF1α ChIP-Seq analysis identifies 81 HIF1α direct target genes in melanocytes. The expression levels for ten of the HIF1α direct targets - GAPDH, PKM, PPAT, DARS, DTWD1, SEH1L, ZNF292, RLF, AGTRAP, and GPC6 - are significantly correlated with reduced time of Disease Free Status (DFS) in melanoma by logistic regression (P-value =0...
February 6, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28162825/safety-of-quadrivalent-live-attenuated-influenza-vaccine-in-subjects-aged-2-49years
#13
Roger Baxter, Abigail Eaton, John Hansen, Laurie Aukes, Herve Caspard, Christopher S Ambrose
BACKGROUND: Quadrivalent live attenuated influenza vaccine (Q/LAIV) was licensed in 2012 and replaced trivalent live attenuated influenza vaccine in the United States during the 2013-2014 influenza season. This study assessed the safety of Q/LAIV in children and adults aged 2-49years. METHODS: This was a prospective observational cohort study using data collected from Kaiser Permanente Northern California. Post-vaccination events of interest were any hospitalization, hospitalization for lower respiratory tract infection, and the following medically attended events: hypersensitivity, seizures/convulsions, lower respiratory tract infection, wheezing, Guillain-Barré syndrome, Bell's palsy, encephalitis, neuritis, vasculitis, and narcolepsy/cataplexy...
February 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28162744/-492-the-role-of-psychosocial-factors-in-the-pain-experience-the-relationship-between-depression-catastrophizing-and-chronic-pain
#14
J Baxter, A Newman, C Torres, J Eyer, B Thorn
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28160285/lessons-learned-transfer-of-the-high-definition-circulating-tumor-cell-assay-platform-to-development-as-a-commercialized-clinical-assay-platform
#15
REVIEW
Peter Kuhn, Susan M Keating, Gregory T Baxter, Kisha Thomas, Anand Kolatkar, Caroline C Sigman
No abstract text is available yet for this article.
February 4, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28160004/in-ovo-evaluation-of-floramax%C3%A2-b11-on-marek%C3%A2-s-disease-hvt-vaccine-protective-efficacy-hatchability-microbiota-composition-morphometric-analysis-and-salmonella-enteritidis-infection-in-broiler-chickens
#16
K D Teague, L E Graham, J R Dunn, H H Cheng, N Anthony, J D Latorre, A Menconi, R E Wolfenden, A D Wolfenden, B D Mahaffey, M Baxter, X Hernandez-Velasco, R Merino-Guzman, L R Bielke, B M Hargis, G Tellez
No abstract text is available yet for this article.
February 4, 2017: Poultry Science
https://www.readbyqxmd.com/read/28159446/in-vitro-activity-of-oritavancin-against-gram-positive-pathogens-isolated-in-canadian-hospital-laboratories-from-2011-to-2015
#17
James A Karlowsky, Andrew J Walkty, Melanie R Baxter, Francis F Arhin, Gregory Moeck, Heather J Adam, George G Zhanel
Gram-positive bacterial pathogens isolated from patient specimens submitted to 15 Canadian hospital laboratories from 2011 to 2015 were tested in the coordinating laboratory for susceptibility to oritavancin and comparative antimicrobial agents using the Clinical and Laboratory Standards Institute M07-A10 (2015) broth microdilution method. Oritavancin's in vitro activity was equivalent to, or more potent than, vancomycin, daptomycin, linezolid, and tigecycline against methicillin-susceptible Staphylococcus aureus (n=2680; oritavancin MIC90, 0...
January 20, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28155283/comparison-of-three-nucleic-acid-based-tests-for-detecting-i-anaplasma-marginale-i-and-i-anaplasma-centrale-i-in-cattle
#18
Mamohale E Chaisi, Janine R Baxter, Paidashe Hove, Chimvwele N Choopa, Marinda C Oosthuizen, Kelly A Brayton, Zamantungwa T H Khumalo, Awelani M Mutshembele, Moses S Mtshali, Nicola E Collins
Several nucleic acid-based assays have been developed for detecting Anaplasma marginale and Anaplasma centrale in vectors and hosts, making the choice of method to use in endemic areas difficult. We evaluated the ability of the reverse line blot (RLB) hybridisation assay, two nested polymerase chain reaction (nPCR) assays and a duplex real-time quantitative polymerase chain reaction (qPCR) assay to detect A. marginale and A. centrale infections in cattle (n = 66) in South Africa. The lowest detection limits for A...
January 23, 2017: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/28148207/clinical-cancer-advances-2017-annual-report-on-progress-against-cancer-from-the-american-society-of-clinical-oncology
#19
Harold J Burstein, Lada Krilov, Jeanny B Aragon-Ching, Nancy N Baxter, E Gabriela Chiorean, Warren Allen Chow, John Frederick De Groot, Steven Michael Devine, Steven G DuBois, Wafik S El-Deiry, Andrew S Epstein, John Heymach, Joshua Adam Jones, Deborah K Mayer, Rebecca A Miksad, Nathan A Pennell, Michael S Sabel, Richard L Schilsky, Lynn Mara Schuchter, Nadine Tung, Karen Marie Winkfield, Lori J Wirth, Don S Dizon
A MESSAGE FROM ASCO'S PRESIDENT I am pleased to present Clinical Cancer Advances 2017, which highlights the most promising advances in patient-oriented cancer research over the past year. The report gives us an opportunity to reflect on what an exciting time it is for cancer research and how swiftly our understanding of cancer has improved. One year ago, the White House announced the national Cancer Moonshot program to accelerate progress against cancer. This shared vision of progress has reinvigorated the research community, identified new areas of scientific collaboration, and raised our ambitions regarding what may be possible beyond the progress we have already made...
February 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28143925/adp-ribosylhydrolase-activity-of-chikungunya-virus-macrodomain-is-critical-for-virus-replication-and-virulence
#20
Robert Lyle McPherson, Rachy Abraham, Easwaran Sreekumar, Shao-En Ong, Shang-Jung Cheng, Victoria K Baxter, Hans A V Kistemaker, Dmitri V Filippov, Diane E Griffin, Anthony K L Leung
Chikungunya virus (CHIKV), an Old World alphavirus, is transmitted to humans by infected mosquitoes and causes acute rash and arthritis, occasionally complicated by neurologic disease and chronic arthritis. One determinant of alphavirus virulence is nonstructural protein 3 (nsP3) that contains a highly conserved MacroD-type macrodomain at the N terminus, but the roles of nsP3 and the macrodomain in virulence have not been defined. Macrodomain is a conserved protein fold found in several plus-strand RNA viruses that binds to the small molecule ADP-ribose...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
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