keyword
MENU ▼
Read by QxMD icon Read
search

Radiation, proton therapy

keyword
https://www.readbyqxmd.com/read/29319640/orbital-extranodal-marginal-zone-lymphoma-following-radiotherapy-a-report-of-2-cases
#1
Zujaja Tauqeer, Frederick A Jakobiec, Suzanne K Freitag, Michael K Yoon, Natalie Wolkow
PURPOSE: To present 2 patients in whom orbital radiation preceded the development of periorbital extranodal marginal zone lymphoma by more than a decade and to investigate the likelihood of this representing irradiation-induced malignancy. METHODS: Retrospective chart review and histopathologic study with immunohistochemistry of 2 cases. RESULTS: The first patient was a 58-year-old woman who developed an orbital mass within the vicinity of the lateral rectus muscle 17 years after external beam proton radiation therapy for an inferotemporal choroidal melanoma...
January 9, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29316969/proton-and-helium-ion-radiotherapy-for-meningioma-tumors-a-monte-carlo-based-treatment-planning-comparison
#2
Thomas Tessonnier, Andrea Mairani, Wenjing Chen, Paola Sala, Francesco Cerutti, Alfredo Ferrari, Thomas Haberer, Jürgen Debus, Katia Parodi
BACKGROUND: Due to their favorable physical and biological properties, helium ion beams are increasingly considered a promising alternative to proton beams for radiation therapy. Hence, this work aims at comparing in-silico the treatment of brain and ocular meningiomas with protons and helium ions, using for the first time a dedicated Monte Carlo (MC) based treatment planning engine (MCTP) thoroughly validated both in terms of physical and biological models. METHODS: Starting from clinical treatment plans of four patients undergoing proton therapy with a fixed relative biological effectiveness (RBE) of 1...
January 9, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29311417/theoretical-and-experimental-comparison-of-proton-and-helium-beam-radiography-using-silicon-pixel-detectors
#3
Tim Gehrke, Carlo Amato, Simon Berke, Maria Martisikova
Ion-beam radiography (iRAD) could potentially improve the quality control of ion-beam therapy. The main advantage of iRAD is the possibility to directly measure the integrated stopping power. Until now there is no clinical implementation of iRAD. Topics of ongoing research include developing dedicated detection systems to achieve the desired spatial resolution (SR) and investigating different ion types as imaging radiation. This work focuses on the theoretical and experimental comparison of proton (pRAD) and helium-beam radiography (αRAD)...
January 9, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29310903/proton-beam-therapy-for-skull-base-chordomas-in-106-patients-a-dose-adaptive-radiation-protocol
#4
Vivien Fung, Valentin Calugaru, Stéphanie Bolle, Hamid Mammar, Claire Alapetite, Philippe Maingon, Ludovic De Marzi, Sébastien Froelich, Jean-Louis Habrand, Rémi Dendale, Georges Noël, Loïc Feuvret
BACKGROUND AND PURPOSE: To evaluate clinical results and safety of a dose adaptive protocol based on tumor volume coverage and critical structure constraints, for the treatment of skull base chordomas. MATERIAL AND METHODS: Between May 2006 and October 2012, 106 patients with skull base chordoma were treated by combined photon and proton irradiation. Prescribed dose levels were 68.4, 70.2, 72 and 73.8 Gy(RBE) in once daily fractionation of 1.8 Gy(RBE). Dose level and dosimetric constraints to organs at risk depended on postoperative residual Gross Tumor Volume (GTV) coverage...
January 6, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29309637/congress-of-neurological-surgeons-systematic-review-and-evidence-based-guidelines-on-the-role-of-radiosurgery-and-radiation-therapy-in-the-management-of-patients-with-vestibular-schwannomas
#5
Isabelle M Germano, Jason Sheehan, Johnathan Parish, Tyler Atkins, Anthony Asher, Constantinos G Hadjipanayis, Stuart H Burri, Sheryl Green, Jeffrey J Olson
Question: What are the indications for stereotactic radiosurgery (SRS) treatment vs observation for patients with intracanalicular vestibular schwannomas without evidence of radiographic progression? Recommendation: Level 3: If tinnitus is not observed at presentation, it is recommended that intracanalicular vestibular schwannomas and small tumors (<2 cm) without tinnitus be observed as observation does not have a negative impact on tumor growth or hearing preservation compared to treatment...
December 20, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29306585/radiation-safety-for-pregnant-workers-at-a-proton-facility
#6
Genevieve Maquilan, Marc R Bussière, Joseph McCormack, Tara Medich, Andrzej Niemierko, Helen A Shih
PURPOSE: To quantify radiation exposure of radiation therapy technologists (RTTs) in a proton treatment facility in comparison with a photon therapy facility, to inform and establish these specialized occupational safety guidelines. METHODS AND MATERIALS: Two groups of RTTs, consisting of 12 full-time passive scattering proton RTTs and 18 full-time conventional photon RTTs, wore an additional dosimetry badge at the waist for a period of 14 weeks. The 2 groups of RTTs were given identical instructions on the proper use of the badges...
November 16, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29303547/hydrogel-nanosensors-for-colorimetric-detection-and-dosimetry-in-proton-beam-radiotherapy
#7
Sahil Inamdar, Karthik Pushpavanam, Jarrod Lentz, Martin Bues, Aman Anand, Kaushal Rege
Proton beam therapy (PBT) is a state-of-the-art radiotherapy treatment approach that uses focused proton beams for tumor ablation.[1] A key advantage of this approach over conventional photon radiotherapy (XRT) is the unique dose deposition characteristics of protons, resulting in superior healthy tissue sparing. This results in fewer unwanted side effects and improved outcomes for patients. Current available dosimeters are intrinsic, complex and expensive; hence cannot be used to determine the dose delivered to the tumor routinely...
January 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29282443/first-ever-use-of-proton-stereotactic-body-radiation-therapy-delivered-with-curative-intent-to-bilateral-synchronous-primary-renal-cell-carcinomas
#8
Melissa A Frick, Arpit M Chhabra, Liyong Lin, Charles B Simone Ii
Limited therapeutic options exist for inoperable bilateral kidney tumors. We report the first ever use of proton therapy to treat primary renal cell carcinoma (RCC) and the first report of proton stereotactic body radiation therapy (SBRT) for RCC in an inoperable patient with synchronous RCCs treated with proton SBRT. The patient is a 47-year-old 450-pound female with multiple medical comorbidities, including Stage 3 chronic kidney disease (CKD), who was found to have bilateral renal masses during work-up for cellulitis and sepsis...
October 24, 2017: Curēus
https://www.readbyqxmd.com/read/29280467/potential-of-proton-therapy-to-reduce-acute-hematologic-toxicity-in-concurrent-chemoradiation-therapy-for-esophageal-cancer
#9
Samantha Warren, Christopher N Hurt, Thomas Crosby, Mike Partridge, Maria A Hawkins
PURPOSE: Radiation therapy dose escalation using a simultaneous integrated boost (SIB) is predicted to improve local tumor control in esophageal cancer; however, any increase in acute hematologic toxicity (HT) could limit the predicted improvement in patient outcomes. Proton therapy has been shown to significantly reduce HT in lung cancer patients receiving concurrent chemotherapy. Therefore, we investigated the potential of bone marrow sparing with protons for esophageal tumors. METHODS AND MATERIALS: Twenty-one patients with mid-esophageal cancer who had undergone conformal radiation therapy (3D50) were selected...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29280461/comparative-outcomes-after-definitive-chemoradiotherapy-using-proton-beam-therapy-versus-intensity-modulated-radiation-therapy-for-esophageal-cancer-a-retrospective-single-institutional-analysis
#10
Mian Xi, Cai Xu, Zhongxing Liao, Joe Y Chang, Daniel R Gomez, Melenda Jeter, James D Cox, Ritsuko Komaki, Reza Mehran, Mariela A Blum, Wayne L Hofstetter, Dipen M Maru, Manoop S Bhutani, Jeffrey H Lee, Brian Weston, Jaffer A Ajani, Steven H Lin
PURPOSE: To compare clinical outcomes between proton beam therapy (PBT) and intensity modulated radiation therapy (IMRT) in patients with esophageal cancer (EC) treated with definitive chemoradiotherapy (CRT). METHODS AND MATERIALS: From 2007 through 2014, 343 EC patients who received definitive CRT with either PBT (n=132) or IMRT (n=211) were retrospectively analyzed. Survival, recurrence, and treatment toxicity were compared between groups. A Cox proportional hazards regression model was performed to test the association between patient/treatment variables and survival...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29280457/reirradiation-for-recurrent-pediatric-central-nervous-system-malignancies-a-multi-institutional-review
#11
Avani D Rao, Arif S Rashid, Qinyu Chen, Rosangela C Villar, Daria Kobyzeva, Kristina Nilsson, Karin Dieckmann, Alexey Nechesnyuk, Ralph Ermoian, Sara Alcorn, Shannon M MacDonald, Matthew M Ladra, Eric C Ford, Brian A Winey, Maria Luisa S Figueiredo, Michael J Chen, Stephanie A Terezakis
PURPOSE: Reirradiation has been proposed as an effective modality for recurrent central nervous system (CNS) malignancies in adults. We evaluated the toxicity and outcomes of CNS reirradiation in pediatric patients. METHODS AND MATERIALS: The data from pediatric patients <21 years of age at the initial diagnosis who developed a recurrent CNS malignancy that received repeat radiation therapy (RT) across 5 facilities in an international pediatric research consortium were retrospectively reviewed...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29279811/radiation-necrosis-following-proton-beam-therapy-in-the-pediatric-population-a-case-series
#12
Justin Davanzo, Robert J Greiner, Mustafa Barbour, Elias Rizk
Radiation necrosis after proton beam radiotherapy in the pediatric population is a finding that should be evaluated. We present two cases of radiation necrosis in pediatric patients who underwent proton beam radiation therapy following gross total resection of tumors. As seen in both our cases, patients often present with radiographic changes found on surveillance imaging. While the progression of disease should certainly be considered in any patient with radiographic changes, understanding the radiographic findings and the clinical course of radiation necrosis is paramount in order to prevent unnecessary surgical intervention...
October 19, 2017: Curēus
https://www.readbyqxmd.com/read/29276214/new-perspective-on-the-treatment-of-intractable-gastrointestinal-cancers-role-of-combination-therapies
#13
Dan G Duda
Unresectable gastrointestinal cancers, such as gastric, hepatocellular, biliary tract or pancreatic carcinomas, are often resistant to anti-cancer systemic therapies, and often recur locally or even after aggressive local therapies leading to dismal survival rates. Recent developments in oncology, have offered renewed hoped for the development of more efficacious therapies. For example, our understanding of the oncogenic drivers in carcinogenesis has increased exponentially, and may potentially allow personalization of therapy...
2017: Keio Journal of Medicine
https://www.readbyqxmd.com/read/29248170/severe-lymphopenia-during-neoadjuvant-chemoradiation-for-esophageal-cancer-a-propensity-matched-analysis-of-the-relative-risk-of-proton-versus-photon-based-radiation-therapy
#14
Yutaka Shiraishi, Penny Fang, Cai Xu, Juhee Song, Sunil Krishnan, Eugene J Koay, Reza J Mehran, Wayne L Hofstetter, Mariela Blum-Murphy, Jaffer A Ajani, Ritsuko Komaki, Bruce Minsky, Radhe Mohan, Charles C Hsu, Brian P Hobbs, Steven H Lin
BACKGROUND AND PURPOSE: Circulating lymphocytes are exquisitely sensitive to radiation exposure, even to low scattered doses which can vary drastically between radiation modalities. We compared the relative risk of radiation-induced lymphopenia between intensity modulated radiation therapy (IMRT) or proton beam therapy (PBT) in esophageal cancer (EC) patients undergoing neoadjuvant chemoradiation therapy (nCRT). MATERIAL AND METHODS: EC patients treated with IMRT and PBT were propensity matched based on key clinical variables...
December 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29248169/simultaneous-integrated-boost-for-radiation-dose-escalation-to-the-gross-tumor-volume-with-intensity-modulated-photon-radiation-therapy-or-intensity-modulated-proton-therapy-and-concurrent-chemotherapy-for-stage-ii-to-iii-non-small-cell-lung-cancer-a-phase
#15
Melenda D Jeter, Daniel Gomez, Quynh-Nhu Nguyen, Ritsuko Komaki, Xiaodong Zhang, Xiaorong Zhu, Michael O'Reilly, Frank V Fossella, Ting Xu, Xiong Wei, Hui Wang, Wenjuan Yang, Anne Tsao, Radhe Mohan, Zhongxing Liao
PURPOSE: To establish, in the phase 1 portion of a prospective phase 1/2 study, the maximum tolerated dose of image guided intensity modulated radiation therapy (IMRT) or proton therapy (IMPT), both with a simultaneous integrated boost (SIB), for patients with stage II to IIIB non-small cell lung cancer receiving concurrent chemoradiation therapy. METHODS AND MATERIALS: Patients had pathologically proven non-small cell lung cancer, either unresectable stage II to IIIB disease or recurrent disease after surgical resection, and could tolerate concurrent chemoradiation...
November 3, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29239262/outcomes-following-proton-therapy-for-pediatric-ependymoma
#16
Daniel J Indelicato, Julie A Bradley, Ronny L Rotondo, Ronica H Nanda, Natalie Logie, Eric S Sandler, Philipp R Aldana, Nathan J Ranalli, Alexandra D Beier, Christopher G Morris, Nancy P Mendenhall
BACKGROUND: Proton therapy can reduce the low and intermediate radiation dose to uninvolved brain tissue in children with intracranial ependymomas, which may improve functional outcomes and reduce second malignancies in survivors. Accordingly, ependymoma has become the most common pediatric tumor treated with proton therapy, yet data on efficacy and toxicity are limited. MATERIAL AND METHODS: Between June 2007 and February 2017, 179 children (≤21 years old) with nonmetastatic grade II/III intracranial ependymoma received proton therapy at our institution...
December 14, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29235123/proof-of-principle-of-helium-beam-radiography-using-silicon-pixel-detectors-for-energy-deposition-measurement-identification-and-tracking-of-single-ions
#17
Tim Gehrke, Raya Gallas, Oliver Jäkel, Maria Martišíková
PURPOSE: Hadron therapy has the capability to provide a high dose conformation to tumor regions. However, it requires an accurate target positioning. Thus, the precise monitoring of the patient's anatomical positioning during treatment is desirable. For this purpose, hadron-beam radiography with protons (pRad) and ions (iRad) could be an attractive tool complementing the conventional imaging technologies. On the pathway to an envisaged clinical application, several challenges have to be addressed...
December 12, 2017: Medical Physics
https://www.readbyqxmd.com/read/29226038/pencil-beam-scanning-proton-therapy-for-rhabdomyosarcoma-of-the-biliary-tract
#18
Luke Pater, Brian Turpin, Anthony Mascia
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with 250-350 cases diagnosed annually in the United States. Biliary tract rhabdomyosarcoma is rare, representing <1% of the RMS cases. Due to its location, resection is clinically challenging, and functional complications exist and persist from biliary obstruction. The anatomical location of this tumor presents both opportunities and challenges for pencil beam scanning proton therapy. Proton therapy offers a dosimetric and clinical advantage by sparing the healthy liver, stomach, contra-lateral kidney and bowel...
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29225692/recent-advances-in-radiation-oncology
#19
REVIEW
Cristina Garibaldi, Barbara Alicja Jereczek-Fossa, Giulia Marvaso, Samantha Dicuonzo, Damaris Patricia Rojas, Federica Cattani, Anna Starzyńska, Delia Ciardo, Alessia Surgo, Maria Cristina Leonardi, Rosalinda Ricotti
Radiotherapy (RT) is very much a technology-driven treatment modality in the management of cancer. RT techniques have changed significantly over the past few decades, thanks to improvements in engineering and computing. We aim to highlight the recent developments in radiation oncology, focusing on the technological and biological advances. We will present state-of-the-art treatment techniques, employing photon beams, such as intensity-modulated RT, volumetric-modulated arc therapy, stereotactic body RT and adaptive RT, which make possible a highly tailored dose distribution with maximum normal tissue sparing...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29225308/evaluation-of-radioactivity-in-the-bodies-of-mice-induced-by-neutron-exposure-from-an-epi-thermal-neutron-source-of-an-accelerator-based-boron-neutron-capture-therapy-system
#20
Satoshi Nakamura, Shoji Imamichi, Kazuyoshi Masumoto, Masashi Ito, Akihisa Wakita, Hiroyuki Okamoto, Shie Nishioka, Kotaro Iijima, Kazuma Kobayashi, Yoshihisa Abe, Hiroshi Igaki, Kazuyoshi Kurita, Teiji Nishio, Mitsuko Masutani, Jun Itami
This study aimed to evaluate the residual radioactivity in mice induced by neutron irradiation with an accelerator-based boron neutron capture therapy (BNCT) system using a solid Li target. The radionuclides and their activities were evaluated using a high-purity germanium (HP-Ge) detector. The saturated radioactivity of the irradiated mouse was estimated to assess the radiation protection needs for using the accelerator-based BNCT system. 24Na, 38Cl, 80mBr, 82Br, 56Mn, and 42K were identified, and their saturated radioactivities were (1...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
keyword
keyword
23521
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"