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Parainfluenza virus

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https://www.readbyqxmd.com/read/29675651/a-multiplex-pcr-method-for-the-simultaneous-detection-of-three-viruses-associated-with-canine-viral-enteric-infections
#1
Xiaoyu Deng, Jiali Zhang, Jiazi Su, Hao Liu, Yanlong Cong, Lei Zhang, Kemeng Zhang, Ning Shi, Rongguang Lu, Xijun Yan
The aim of this study was to establish a multiplex PCR (mPCR) method that can simultaneously detect canine parvovirus (CPV-2), canine coronavirus (CCoV) and canine adenovirus (CAV), thereby eliminating the need to detect these pathogens individually. Based on conserved regions in the genomes of these three viruses, the VP2 gene of CPV-2, the endoribonuclease nsp15 gene of CCoV, and the 52K gene of CAV were selected for primer design. The specificity of the mPCR results showed no amplification of canine distemper virus (CDV), canine parainfluenza virus (CPIV), or pseudorabies virus (PRV), indicating that the method had good specificity...
April 19, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29673810/a-systematic-review-of-emerging-respiratory-viruses-at-the-hajj-and-possible-coinfection-with-streptococcus-pneumoniae
#2
REVIEW
Jaffar A Al-Tawfiq, Samir Benkouiten, Ziad A Memish
BACKGROUND: The annual Hajj to the Kingdom of Saudi Arabia attracts millions of pilgrims from around the world. International health community's attention goes towards this mass gathering and the possibility of the development of any respiratory tract infections due to the high risk of acquisition of respiratory viruses. METHOD: We searched MEDLINE/PubMed and Scopus databases for relevant papers describing the prevalence of respiratory viruses among Hajj pilgrims...
April 16, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29672244/seroprevalence-of-human-parainfluenza-virus-types-1-4-among-healthy-children-under-5-years-of-age-in-korea
#3
Geunha Park, Joo Young Lee, Soo Young Lee, Jong-Hyun Kim, Jin Han Kang, Ui Yoon Choi
Human parainfluenza viruses (HPIVs) are among the major causes of respiratory infections in children, worldwide, including in Korea. There are four types of HPIVs, each with different epidemiological characteristics. HPIV3 is the most frequently circulating HPIV type, while the epidemiology of HPIV4 remains unclear. The aim of this study was to investigate the age-stratified seropositivity rates of HPIV types 1-4 among children in Korea. These data will be useful to determine vaccine requirements. This study included 245 participants categorized into four age groups: 6-11 months, 1 year, 2 years, and 3-5 years...
April 19, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29666961/a-novel-sampling-method-to-detect-airborne-influenza-and-other-respiratory-viruses-in-mechanically-ventilated-patients-a-feasibility-study
#4
Alicia B Mitchell, Benjamin Tang, Maryam Shojaei, Lachlan S Barnes, Marek Nalos, Brian G Oliver, Anthony S McLean
BACKGROUND: Respiratory viruses circulate constantly in the ambient air. The risk of opportunistic infection from these viruses can be increased in mechanically ventilated patients. The present study evaluates the feasibility of detecting airborne respiratory viruses in mechanically ventilated patients using a novel sample collection method involving ventilator filters. METHODS: We collected inspiratory and expiratory filters from the ventilator circuits of mechanically ventilated patients in an intensive care unit over a 14-month period...
April 17, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29663437/usefulness-of-national-respiratory-virus-surveillance-data-for-clinicians-who-manage-adult-patients
#5
Eun Been Cho, Seong-Ho Choi, Jin-Won Chung, Mi-Kyung Lee
The Korean Centers for Disease Control and Prevention (KCDC) provides weekly respiratory virus (RV) surveillance reports on its website (the KCDC data). Clinicians in clinical settings wherein the use of PCR for RVs is not a routine laboratory test for adult patients with acute respiratory illness (ARI) may question the clinical utility of such a national RV surveillance dataset in predicting RV outbreaks among their adult patients. We compared the KCDC data to the RV PCR data of adult patients who visited a tertiary care center...
April 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29651410/analysis-of-micrornas-expression-profiles-in-madin-darby-bovine-kidney-cells-infected-with-caprine-parainfluenza-virus-type-3
#6
Jizong Li, Li Mao, Wenliang Li, Fei Hao, Chunyan Zhong, Xing Zhu, Xinqin Ji, Leilei Yang, Wenwen Zhang, Maojun Liu, Jieyuan Jiang
Caprine parainfluenza virus type 3 (CPIV3) is a newly emerging pathogenic respiratory agent infecting both young and adult goats, and it was identified in eastern China in 2013. Cellular microRNAs (miRNAs) have been reported to be important modulators of the intricate virus-host interactions. In order to elucidate the role of miRNAs in madin-darby bovine kidney (MDBK) cells during CPIV3 infection. In this study, we performed high-throughput sequencing technology to analyze small RNA libraries in CPIV3-infected and mock-infected MDBK cells...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29644701/usefulness-of-national-respiratory-virus-surveillance-data-for-clinicians-who-manage-adult-patients
#7
Eun Been Cho, Seong-Ho Choi, Jin-Won Chung, Mi-Kyung Lee
The Korean Centers for Disease Control and Prevention (KCDC) provides weekly respiratory virus (RV) surveillance reports on its website (the KCDC data). Clinicians in clinical settings wherein the use of PCR for RVs is not a routine laboratory test for adult patients with acute respiratory illness (ARI) may question the clinical utility of such a national RV surveillance dataset in predicting RV outbreaks among their adult patients. We compared the KCDC data to the RV PCR data of adult patients who visited a tertiary care center...
April 12, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29621258/diva-metabolomics-differentiating-vaccination-status-following-viral-challenge-using-metabolomic-profiles
#8
Darren W Gray, Michael D Welsh, Fawad Mansoor, Simon Doherty, Olivier P Chevallier, Christopher T Elliott, Mark H Mooney
Bovine Respiratory Disease (BRD) is a major source of economic loss within the agricultural industry. Vaccination against BRD-associated viruses does not offer complete immune protection and vaccine failure animals present potential routes for disease spread. Serological differentiation of infected from vaccinated animals (DIVA) is possible using antigen-deleted vaccines, but during virus outbreaks DIVA responses are masked by wild-type virus preventing accurate serodiagnosis. Previous work by the authors has established the potential for metabolomic profiling to reveal metabolites associated with systemic immune responses to vaccination...
2018: PloS One
https://www.readbyqxmd.com/read/29620934/factors-associated-with-lower-respiratory-tract-infections-in-hiv-exposed-uninfected-infants
#9
Adriana Weinberg, Marisa Mussi-Pinhata, Qilu Yu, Rachel A Cohen, Volia C Almeida, Fabiana R Amaral, Laura Freimanis, D Robert Harris, Christiana Smith, George Siberry
OBJECTIVES: To identify factors that predispose HIV-exposed uninfected infants (HEUs) to higher incidence of severe infections, hospitalization and death in the first 6 to 24 months of life compared with HEUs with and without lower respiratory tract infection (LRTI) in the first 6 months of life. DESIGN: Nested case-control study of 107 LRTI+ infants enrolled in the NISDI Perinatal and LILAC studies with and 140 LRTI- in the first 6 months of, matched by date and place of birth...
March 18, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29617951/non-mumps-viral-parotitis-during-the-2014-2015-influenza-season-in-the-united-states
#10
Lina I Elbadawi, Pamela Talley, Melissa A Rolfes, Alexander J Millman, Erik Reisdorf, Natalie A Kramer, John R Barnes, Lenee Blanton, Jaime Christensen, Stefanie Cole, Tonya Danz, John J Dreisig, Rebecca Garten, Thomas Haupt, Beth M Isaac, Mary Anne Jackson, Anna Kocharian, Daniel Leifer, Karen Martin, Lisa McHugh, Rebecca J McNall, Jennifer Palm, Kay W Radford, Sara Robinson, Jennifer B Rosen, Senthilkumar K Sakthivel, Peter Shult, Anna K Strain, George Turabelidze, Lori A Webber, Meghan Pearce Weinberg, David E Wentworth, Brett L Whitaker, Lyn Finelli, Michael A Jhung, Ruth Lynfield, Jeffrey P Davis
Background: During the 2014-2015 US influenza season, 320 cases of non-mumps parotitis (NMP) among residents of 21 states were reported to the Centers for Disease Control and Prevention (CDC). We conducted an epidemiologic and laboratory investigation to determine viral etiologies and clinical features of NMP during this unusually large occurrence. Methods: NMP was defined as acute parotitis or other salivary gland swelling of >2 days duration in a person with a mumps- negative laboratory result...
March 30, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29601894/susceptibility-of-paramyxoviruses-and-filoviruses-to-inhibition-by-2-monofluoro-and-2-difluoro-4-azidocytidine-analogs
#11
Michael K Lo, Paul C Jordan, Sarah Stevens, Yuen Tam, Jerome Deval, Stuart T Nichol, Christina F Spiropoulou
Ebolaviruses, marburgviruses, and henipaviruses are zoonotic pathogens belonging to the Filoviridae and Paramyxoviridae families. They exemplify viruses that continue to spill over into the human population, causing outbreaks characterized by high mortality and significant clinical sequelae in survivors of infection. There are currently no approved small molecule therapeutics for use in humans against these viruses. In this study, we evaluated the antiviral activity of the nucleoside analog 4'-azidocytidine (4'N3 -C, R1479) and its 2'-monofluoro- and 2'-difluoro-modified analogs (2'F-4'N3 -C and 2'diF-4'N3 -C) against representative paramyxoviruses (Nipah virus, Hendra virus, measles virus, and human parainfluenza virus 3) and filoviruses (Ebola virus, Sudan virus, and Ravn virus)...
March 27, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29599424/epidemiology-and-seasonality-of-respiratory-viruses-detected-from-children-with-respiratory-tract-infections-in-wuxi-east-china
#12
Xiaoli Ge, Yi Guo, JuanJuan Chen, Renjing Hu, Xing Feng
BACKGROUND Respiratory tract infections (RTIs) are the major causes of mortality and morbidity in children and lead to hospitalization in developing countries. However, little is known about the epidemiology and seasonality of respiratory viruses in the pediatric population in Wuxi, East China. MATERIAL AND METHODS We included all patients 14 years of age and below who presented with signs and symptoms of RTIs between January 2010 and December 2016. During this period, a total of 2160 children treated in Wuxi No...
March 30, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29596527/influenza-virus-16-years-experience-of-clinical-epidemiologic-patterns-and-associated-infection-factors-in-hospitalized-children-in-argentina
#13
Angela Gentile, Maria Florencia Lucion, Maria Del Valle Juarez, Ana Clara Martinez, Viviana Romanin, Julia Bakir, Mariana Viegas, Alicia Mistchenko
BACKGROUND: Influenza is an important cause of acute lower respiratory tract infection (aLRTI), hospitalization, and mortality in children. This study aimed to describe the clinical and epidemiologic patterns and infection factors associated with influenza, and compare case features of influenza A and B. METHODS: In a prospective, cross-sectional study, patients admitted for aLRTI, between 2000 and 2015, were tested for respiratory syncytial virus, adenovirus, influenza, or parainfluenza, and confirmed by fluorescent antibody (FA) or real-time polymerase chain reaction (RT-PCR) assay of nasopharyngeal aspirates...
2018: PloS One
https://www.readbyqxmd.com/read/29593671/the-hemagglutinin-neuraminidase-hn-head-domain-and-the-fusion-f-protein-stalk-domain-of-the-parainfluenza-viruses-affect-the-specificity-of-the-hn-f-interaction
#14
Masato Tsurudome, Junpei Ohtsuka, Morihiro Ito, Machiko Nishio, Tetsuya Nosaka
Membrane fusion by the parainfluenza viruses is induced by virus-specific functional interaction between the attachment protein (HN) and the fusion (F) protein. This interaction is thought to be mediated by transient contacts between particular amino acids in the HN stalk domain and those in the F head domain. However, we recently reported that replacement of specified amino acids at or around the dimer interface of the HN head domain remarkably affected the F protein specificity. We then intended to further investigate this issue in the present study and revealed that the HPIV2 HN protein can be converted to an SV41 HN-like protein by substituting at least nine amino acids in the HPIV2 HN head domain with the SV41 HN counterparts in addition to the replacement of the stalk domain, indicating that specified amino acids in the HN head domain play very important roles in determining the specificity of the HN-F interaction...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29593057/multicenter-evaluation-of-the-biofire-filmarray-respiratory-panel-2-for-the-detection-of-viruses-and-bacteria-in-nasopharyngeal-swab-samples
#15
Amy L Leber, Kathy Everhart, Judy A Daly, Aubrey Hopper, Amanda Harrington, Paul Schreckenberger, Kathleen McKinley, Matthew Jones, Kristen Holmberg, Bart Kensinger
The FilmArray® Respiratory Panel 2 (RP2) is a multiplex in vitro diagnostic test for the simultaneous and rapid (∼45 minutes) detection of 22 pathogens directly from nasopharyngeal swab (NPS) samples. It contains updated (and in some instances redesigned) assays that improve upon the FilmArray® Respiratory Panel (RP; version 1.7), with a faster run time. The organisms identified are adenovirus, coronavirus 229E, coronavirus HKU1, coronavirus NL63, coronavirus OC43, human metapneumovirus, human rhinovirus/enterovirus, influenza A, influenza A H1, influenza A H1-2009, influenza A H3, influenza B, parainfluenza virus 1, parainfluenza virus 2, parainfluenza virus 3, parainfluenza virus 4, respiratory syncytial virus, Bordetella pertussis , Chlamydia pneumoniae , and Mycoplasma pneumoniae...
March 28, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29562753/nucleosides-for-the-treatment-of-respiratory-rna-virus-infections
#16
Paul C Jordan, Sarah K Stevens, Jerome Deval
Influenza virus, respiratory syncytial virus, human metapneumovirus, parainfluenza virus, coronaviruses, and rhinoviruses are among the most common viruses causing mild seasonal colds. These RNA viruses can also cause lower respiratory tract infections leading to bronchiolitis and pneumonia. Young children, the elderly, and patients with compromised cardiac, pulmonary, or immune systems are at greatest risk for serious disease associated with these RNA virus respiratory infections. In addition, swine and avian influenza viruses, together with severe acute respiratory syndrome-associated and Middle Eastern respiratory syndrome coronaviruses, represent significant pandemic threats to the general population...
January 2018: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/29538674/a-multicenter-consortium-to-define-the-epidemiology-and-outcomes-of-pediatric-solid-organ-transplant-recipients-with-inpatient-respiratory-virus-infection
#17
Lara Danziger-Isakov, William J Steinbach, Grant Paulsen, Flor M Munoz, Leigh R Sweet, Michael Green, Marian G Michaels, Janet A Englund, Alastair Murray, Natasha Halasa, Daniel E Dulek, Rebecca Pellett Madan, Betsy C Herold, Brian T Fisher
Background: Respiratory virus infection (RVI) in pediatric solid organ transplant (SOT) recipients poses a significant risk; however, the epidemiology and effects of an RVI after pediatric SOT in the era of current molecular diagnostic assays are unclear. Methods: A retrospective observational cohort of pediatric SOT recipients (January 2010 to June 2013) was assembled from 9 US pediatric transplant centers. Charts were reviewed for RVI events associated with hospitalization within 1 year after the transplant...
March 10, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29534486/human-parainfluenza-virus-type-3-matrix-protein-reduces-viral-rna-synthesis-of-hpiv3-by-regulating-inclusion-body-formation
#18
Shengwei Zhang, Qi Cheng, Chenxi Luo, Yali Qin, Mingzhou Chen
Human parainfluenza virus type 3 is one of the main causes of lower respiratory illness in newborns and infants. The role of the matrix protein (M) in viral budding is extensively studied, but the effect of M on viral replication remains to be determined. Using an HPIV3 minigenome assay, we found that M reduced HPIV3 mingenome-encoded reporter activity even though it had an unspecific effect on the expression of cellular genes. Furthermore, the inhibition effect of M on viral RNA synthesis was proven to be independent of its virus-like particles (VLPs)' release ability...
March 11, 2018: Viruses
https://www.readbyqxmd.com/read/29518269/viral-etiologies-of-influenza-like-illness-and-severe-acute-respiratory-infections-in-thailand
#19
Malinee Chittaganpitch, Sunthareeya Waicharoen, Thitipong Yingyong, Prabda Praphasiri, Somchai Sangkitporn, Sonja J Olsen, Kim A Lindblade
BACKGROUND: Information on the burden, characteristics and seasonality of non-influenza respiratory viruses is limited in tropical countries. OBJECTIVES: Describe the epidemiology of selected non-influenza respiratory viruses in Thailand between June 2010 and May 2014 using a sentinel surveillance platform established for influenza. METHODS: Patients with influenza-like illness (ILI; history of fever or documented temperature >38°C, cough, not requiring hospitalization) or severe acute respiratory infection (SARI; history of fever or documented temperature >38°C, cough, onset <10 days, requiring hospitalization) were enrolled from 10 sites...
March 8, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29518158/inclusion-bodies-of-human-parainfluenza-virus-type-3-inhibit-antiviral-stress-granule-formation-by-shielding-viral-rnas
#20
Zhulong Hu, Yuang Wang, Qiaopeng Tang, Xiaodan Yang, Yali Qin, Mingzhou Chen
Viral invasion triggers the activation of the host antiviral response. Besides the innate immune response, stress granules (SGs) also act as an additional defense response to combat viral replication. However, many viruses have evolved various strategies to suppress SG formation to facilitate their own replication. Here, we show that viral mRNAs derived from human parainfluenza virus type 3 (HPIV3) infection induce SG formation in an eIF2α phosphorylation- and PKR-dependent manner in which viral mRNAs are sequestered and viral replication is inhibited independent of the interferon signaling pathway...
March 8, 2018: PLoS Pathogens
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