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https://www.readbyqxmd.com/read/29908521/respiratory-viruses-among-children-with-non-severe-community-acquired-pneumonia-a-prospective-cohort-study
#1
Amanda C Nascimento-Carvalho, Ana-Luisa Vilas-Boas, Maria-Socorro H Fontoura, Tytti Vuorinen, Cristiana M Nascimento-Carvalho
BACKGROUND: Community-acquired pneumonia (CAP) causes a major burden to the health care system among children under-5 years worldwide. Information on respiratory viruses in non-severe CAP cases is scarce. OBJECTIVES: To estimate the frequency of respiratory viruses among non-severe CAP cases. STUDY DESIGN: Prospective study conducted in Salvador, Brazil. Out of 820 children aged 2-59 months with non-severe CAP diagnosed by pediatricians (respiratory complaints and radiographic pulmonary infiltrate/consolidation), recruited in a clinical trial (ClinicalTrials...
June 6, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29889810/pathogen-clearance-and-new-respiratory-tract-infections-among-febrile-children-in-zanzibar-investigated-with-multitargeting-real-time-polymerase-chain-reaction-on-paired-nasopharyngeal-swab-samples
#2
Kristina Elfving, Deler Shakely, Maria Andersson, Kimberly Baltzell, Mwinyi I Msellem, Anders Björkman, Andreas Mårtensson, Max Petzold, Birger Trollfors, Magnus Lindh
BACKGROUND: New molecular methods have revealed frequent and often polymicrobial respiratory infections in children in low-income settings. It is not known whether presence of multiple pathogens is due to prolonged infections or to frequent exposure. The aim of this study was to analyze short-term pathogen clearance from nasopharynx and the rate of new respiratory tract infections in febrile preschool children. METHODS: Children (n = 207) with uncomplicated acute febrile illness 2-59 months of age presenting to a health center in Zanzibar, Tanzania, April-July 2011, were included...
July 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29866794/respiratory-viruses-and-treatment-failure-in-children-with-asthma-exacerbation
#3
Joanna Merckx, Francine M Ducharme, Christine Martineau, Roger Zemek, Jocelyn Gravel, Dominic Chalut, Naveen Poonai, Caroline Quach
: media-1vid110.1542/5771275574001PEDS-VA_2017-4105 Video Abstract OBJECTIVES: Respiratory pathogens commonly trigger pediatric asthma exacerbations, but their impact on severity and treatment response remains unclear. METHODS: We performed a secondary analysis of the Determinants of Oral Corticosteroid Responsiveness in Wheezing Asthmatic Youth (DOORWAY) study, a prospective cohort study of children (aged 1-17 years) presenting to the emergency department with moderate or severe exacerbations...
June 4, 2018: Pediatrics
https://www.readbyqxmd.com/read/29858879/primary-care-influenza-like-illness-surveillance-in-ho-chi-minh-city-vietnam-2013-2015
#4
Stacy Todd, Nguyen Thi Cam Huong, Nguyen Thi Le Thanh, Nguyen Ha Thao Vy, Nguyen Thanh Hung, Tran Thi Nhu Thao, Huynh Thi Phuong, H Rogier van Doorn, V T Ty Hang, Nguyen Van Vinh Chau, Jonathan M Read, David G Lalloo, Maciej F Boni
BACKGROUND: Year-round transmission of influenza has been detected in Vietnam through both national surveillance and other epidemiological studies. Understanding the demographic and clinical features of influenza-like-illness (ILI) presenting to primary care in urban Vietnam is vital to understand these transmission dynamics. METHODS: A prospective, observational study of patients with ILI in Ho Chi Minh City, Vietnam was conducted between August 2013 and November 2015 in a mix of public and private primary care settings...
June 2, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29851817/age-related-prevalence-of-common-upper-respiratory-pathogens-based-on-the-application-of-the-filmarray-respiratory-panel-in-a-tertiary-hospital-in-greece
#5
Nikolaos J Tsagarakis, Anthi Sideri, Panagiotis Makridis, Argyro Triantafyllou, Alexandra Stamoulakatou, Eleni Papadogeorgaki
The FilmArray Respiratory Panel (FA-RP) is an FDA certified multiplex PCR that can detect 17 viruses and 3 bacteria responsible for upper respiratory tract infections, thus it is potentially useful to the assessment of the age-related prevalence of these pathogens.In this observational study, we retrospectively analyzed the results of all the respiratory samples, which had been processed during 1 year-period (November 2015 to November 2016) with the FA-RP, in the Central Laboratories of Hygeia & Mitera General Hospitals of Athens, Greece...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29793965/evaluation-of-performance-characteristics-of-panther-fusion-assays-for-the-detection-of-respiratory-viruses-from-nasopharyngeal-and-lower-respiratory-tract-specimens
#6
Soya S Sam, Angela M Caliendo, Jessica Ingersoll, Deborah Abdul-Ali, Charles E Hill, Colleen S Kraft
Accurate and rapid diagnosis is needed for timely intervention and clinical management of acute respiratory infections. This study evaluated performance characteristics of the Fusion assay for the detection of influenza A (Flu A), influenza B (Flu B), respiratory syncytial virus (RSV), parainfluenza 1-3 (Para 1-3), human metapneumovirus (hMPV), rhinovirus (RV) and adenovirus (Adeno) targets in comparison to the eSensor and Lyra assays using 395 nasopharyngeal (NP) and 104 lower respiratory tract (LRT) specimens...
May 23, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29783756/pre-clinical-and-clinical-efficiency-of-complexes-of-oligoribonucleotides-with-d-mannitol-against-respiratory-viruses
#7
Nataliia Melnichuk, Vladimir Zarubaev, Iaryna Iosyk, Mychaylo Andreychyn, Larisa Semernikova, Zenoviy Tkachuk
Oligoribonucleotides-D-mannitol (ORNs-D-M) complexes possess antiviral, anti-inflammatory, and immunomodulatory actions. The aim of the present study was to evaluated an antiviral effect of ORNs-D-M against parainfluenza virus type 3 (PIV3); influenza CA709, PR834; avian influenza virus H5N2 (AIV) in vitro by a TCID50 ; hemadsorption and neuraminidase activity assays; and clinical efficiency of ORNs-D-M in patients with acute respiratory infections (ARIs) of various etiologies by PCR assay and AmpliSens test systems...
May 19, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29780847/community-acquired-respiratory-paramyxovirus-infection-after-allogeneic-hematopoietic-cell-transplantation-a-single-center-experience
#8
Yasmin Spahr, Sarah Tschudin-Sutter, Veronika Baettig, Francesca Compagno, Michael Tamm, Jörg Halter, Sabine Gerull, Jakob Passweg, Hans H Hirsch, Nina Khanna
Background: Paramyxoviruses include respiratory syncytial virus (RSV), parainfluenza virus (PIV), and human metapneumovirus (MPV), which may cause significant respiratory tract infectious disease (RTID) and mortality after allogeneic hematopoietic cell transplantation (HCT). However, clinical data regarding frequency and outcome are scarce. Methods: We identified all paramyxovirus RTIDs in allogeneic HCT recipients diagnosed by multiplex polymerase chain reaction between 2010 and 2014...
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29780032/severe-outcomes-associated-with-respiratory-viruses-in-newborns-and-infants-a-prospective-viral-surveillance-study-in-jordan
#9
Najwa Khuri-Bulos, Lindsey Lawrence, Bhinnata Piya, Li Wang, Christopher Fonnesbeck, Samir Faouri, Asem Shehabi, Sten H Vermund, John V Williams, Natasha B Halasa
OBJECTIVE: To assess virus-specific hospitalisation rates, risk factors for illness severity and seasonal trends in children hospitalised with acute respiratory infections (ARI). DESIGN: Prospective cohort study. SETTING: A government hospital serving low-income and middle-income population in Amman, Jordan. PARTICIPANTS: Children under 2 years of age hospitalised with fever and/or respiratory symptoms (n=3168) from 16 March 2010 to 31 March 2013...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29777867/antibiotic-exposure-prior-to-respiratory-viral-infection-is-associated-with-progression-to-lower-respiratory-tract-disease-in-allogeneic-hematopoietic-cell-transplant-recipients
#10
Chikara Ogimi, Elizabeth M Krantz, Jonathan L Golob, Alpana Waghmare, Catherine Liu, Wendy M Leisenring, Christopher R Woodard, Sara Marquis, Jane M Kuypers, Keith R Jerome, Steven A Pergam, David N Fredricks, Mohamed L Sorror, Janet A Englund, Michael Boeckh
INTRODUCTION: Recent publications note an association between antibiotic exposure and respiratory viral infections (RVIs). Antibiotics affect microbiota and impair immune response against RVIs in mice, and low microbiome diversity is associated with pulmonary complications including viral lower respiratory tract disease (LRTD) in hematopoietic cell transplantation (HCT) recipients. In this study, we examined whether antibiotic exposure was associated with increased risk of disease progression in RVIs post-transplantation...
May 16, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29771962/progression-of-the-radiologic-severity-index-predicts-mortality-in-patients-with-parainfluenza-virus-associated-lower-respiratory-infections
#11
Ajay Sheshadri, Dimpy P Shah, Myrna Godoy, Jeremy J Erasmus, Juhee Song, Liang Li, Scott E Evans, Roy F Chemaly, Burton F Dickey, David E Ost
BACKGROUND: Radiologic severity may predict adverse outcomes after lower respiratory tract infection (LRI). However, few studies have quantified radiologic severity of LRIs. We sought to evaluate whether a semi-quantitative scoring tool, the Radiologic Severity Index (RSI), predicted mortality after parainfluenza virus (PIV)-associated LRI. METHODS: We conducted a retrospective review of consecutively-enrolled adult patients with hematologic malignancy or hematopoietic stem cell transplantation and with PIV detected in nasal wash who subsequently developed radiologically-confirmed LRI...
2018: PloS One
https://www.readbyqxmd.com/read/29750672/infusion-of-cytotoxic-t-lymphocytes-for-the-treatment-of-viral-infections-in-hematopoetic-stem-cell-transplant-patients
#12
Katherine A Baugh, Ifigeneia Tzannou, Ann M Leen
PURPOSE OF REVIEW: Allogeneic hematopoietic stem cell transplantation has proven curative for a range of malignant and nonmalignant disorders. However, the clinical success of this therapy is marred by the morbidity associated with viral infections, which are frequent (cytomegalovirus 15.6-28%, adenovirus 3-21%, BK virus 18.5-20.7%) post-transplant. These infections occur as a consequence of transplant conditioning regimens designed to eliminate not only malignant cells but also host immune cells that might interfere with stem cell engraftment...
May 9, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29717150/clinical-and-molecular-epidemiology-of-human-parainfluenza-viruses-1-4-in-children-from-viet-nam
#13
Martin Linster, Lien Anh Ha Do, Ngo Ngoc Quang Minh, Yihui Chen, Zhu Zhe, Tran Anh Tuan, Ha Manh Tuan, Yvonne C F Su, H Rogier van Doorn, Mahesh Moorthy, Gavin J D Smith
HPIVs are serologically and genetically grouped into four species that account for up to 10% of all hospitalizations due to acute respiratory infection in children under the age of five. Genetic and epidemiological data for the four HPIVs derived from two pediatric cohorts in Viet Nam are presented. Respiratory samples were screened for HPIV1-4 by real-time PCR. Demographic and clinical data of patients infected with different HPIV were compared. We used a hemi-nested PCR approach to generate viral genome sequences from HPIV-positive samples and conducted a comprehensive phylogenetic analysis...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29693588/relative-contribution-of-cellular-complement-inhibitors-cd59-cd46-and-cd55-to-parainfluenza-virus-5-inhibition-of-complement-mediated-neutralization
#14
Yujia Li, Griffith D Parks
The complement system is a part of the innate immune system that viruses need to face during infections. Many viruses incorporate cellular regulators of complement activation (RCA) to block complement pathways and our prior work has shown that Parainfluenza virus 5 (PIV5) incorporates CD55 and CD46 to delay complement-mediated neutralization. In this paper, we tested the role of a third individual RCA inhibitor CD59 in PIV5 interactions with complement pathways. Using a cell line engineered to express CD59, we show that small levels of functional CD59 are associated with progeny PIV5, which is capable of blocking assembly of the C5b-C9 membrane attack complex (MAC)...
April 25, 2018: Viruses
https://www.readbyqxmd.com/read/29693380/structural-insights-into-human-parainfluenza-virus-type-3-haemagglutinin-neuraminidase-using-unsaturated-3-n-substituted-sialic-acids-as-probes
#15
Mauro Pascolutti, Larissa Dirr, Patrice Guillon, Annelies Van Den Bergh, Thomas Ve, Robin J Thomson, Mark von Itzstein
A novel approach to human parainfluenza virus type-3 (hPIV-3) inhibitor design has been evaluated by targeting an unexplored pocket within the active site region of the virus' haemagglutinin-neuraminidase (HN) that is normally occluded upon ligand engagement. To explore this opportunity, we developed a highly efficient route to introduce nitrogen-based functionalities at the naturally unsubstituted C-3 position on the neuraminidase inhibitor template N-acyl-2,3-dehydro-2-deoxy-neuraminic acid (N-acyl-Neu2en), via a regioselective 2,3-bromoazidation...
April 25, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29686673/the-cd8-t-cell-response-to-respiratory-virus-infections
#16
REVIEW
Megan E Schmidt, Steven M Varga
Humans are highly susceptible to infection with respiratory viruses including respiratory syncytial virus (RSV), influenza virus, human metapneumovirus, rhinovirus, coronavirus, and parainfluenza virus. While some viruses simply cause symptoms of the common cold, many respiratory viruses induce severe bronchiolitis, pneumonia, and even death following infection. Despite the immense clinical burden, the majority of the most common pulmonary viruses lack long-lasting efficacious vaccines. Nearly all current vaccination strategies are designed to elicit broadly neutralizing antibodies, which prevent severe disease following a subsequent infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29675651/a-multiplex-pcr-method-for-the-simultaneous-detection-of-three-viruses-associated-with-canine-viral-enteric-infections
#17
Xiaoyu Deng, Jiali Zhang, Jiazi Su, Hao Liu, Yanlong Cong, Lei Zhang, Kemeng Zhang, Ning Shi, Rongguang Lu, Xijun Yan
The aim of this study was to establish a multiplex PCR (mPCR) method that can simultaneously detect canine parvovirus (CPV-2), canine coronavirus (CCoV) and canine adenovirus (CAV), thereby eliminating the need to detect these pathogens individually. Based on conserved regions in the genomes of these three viruses, the VP2 gene of CPV-2, the endoribonuclease nsp15 gene of CCoV, and the 52K gene of CAV were selected for primer design. The specificity of the mPCR results showed no amplification of canine distemper virus (CDV), canine parainfluenza virus (CPIV), or pseudorabies virus (PRV), indicating that the method had good specificity...
April 19, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29673810/a-systematic-review-of-emerging-respiratory-viruses-at-the-hajj-and-possible-coinfection-with-streptococcus-pneumoniae
#18
REVIEW
Jaffar A Al-Tawfiq, Samir Benkouiten, Ziad A Memish
BACKGROUND: The annual Hajj to the Kingdom of Saudi Arabia attracts millions of pilgrims from around the world. International health community's attention goes towards this mass gathering and the possibility of the development of any respiratory tract infections due to the high risk of acquisition of respiratory viruses. METHOD: We searched MEDLINE/PubMed and Scopus databases for relevant papers describing the prevalence of respiratory viruses among Hajj pilgrims...
April 16, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29672244/seroprevalence-of-human-parainfluenza-virus-types-1-4-among-healthy-children-under-5-years-of-age-in-korea
#19
Geunha Park, Joo Young Lee, Soo Young Lee, Jong-Hyun Kim, Jin Han Kang, Ui Yoon Choi
Human parainfluenza viruses (HPIVs) are among the major causes of respiratory infections in children, worldwide, including in Korea. There are four types of HPIVs, each with different epidemiological characteristics. HPIV3 is the most frequently circulating HPIV type, while the epidemiology of HPIV4 remains unclear. The aim of this study was to investigate the age-stratified seropositivity rates of HPIV types 1-4 among children in Korea. These data will be useful to determine vaccine requirements. This study included 245 participants categorized into four age groups: 6-11 months, 1 year, 2 years, and 3-5 years...
June 2018: Viral Immunology
https://www.readbyqxmd.com/read/29666961/a-novel-sampling-method-to-detect-airborne-influenza-and-other-respiratory-viruses-in-mechanically-ventilated-patients-a-feasibility-study
#20
Alicia B Mitchell, Benjamin Tang, Maryam Shojaei, Lachlan S Barnes, Marek Nalos, Brian G Oliver, Anthony S McLean
BACKGROUND: Respiratory viruses circulate constantly in the ambient air. The risk of opportunistic infection from these viruses can be increased in mechanically ventilated patients. The present study evaluates the feasibility of detecting airborne respiratory viruses in mechanically ventilated patients using a novel sample collection method involving ventilator filters. METHODS: We collected inspiratory and expiratory filters from the ventilator circuits of mechanically ventilated patients in an intensive care unit over a 14-month period...
April 17, 2018: Annals of Intensive Care
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