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Parainfluenza virus

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https://www.readbyqxmd.com/read/29224300/-etiological-analysis-and-establishment-of-a-discriminant-model-for-lower-respiratory-tract-infections-in-hospitalized-patients
#1
Y S Chen, X H Lin, H R Li, Z D Hua, M Q Lin, W S Huang, T Yu, H Y Lyu, W P Mao, Y Q Liang, X R Peng, S J Chen, H Zheng, S Q Lian, X L Hu, X Q Yao
Objective: To analyze the pathogens of lower respiratory tract infection(LRTI) including bacterial, viral and mixed infection, and to establish a discriminant model based on clinical features in order to predict the pathogens. Methods: A total of 243 hospitalized patients with lower respiratory tract infections were enrolled in Fujian Provincial Hospital from April 2012 to September 2015. The clinical data and airway (sputum and/or bronchoalveolar lavage) samples were collected. Microbes were identified by traditional culture (for bacteria), loop-mediated isothermal amplification(LAMP) and gene sequencing (for bacteria and atypical pathogen), or Real-time quantitative polymerase chain reaction (Real-time PCR)for viruses...
December 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29223400/a-new-comprehensive-method-for-detection-of-livestock-related-pathogenic-viruses-using-a-target-enrichment-system
#2
Mami Oba, Shinobu Tsuchiaka, Tsutomu Omatsu, Yukie Katayama, Konosuke Otomaru, Teppei Hirata, Hiroshi Aoki, Yoshiteru Murata, Shinji Makino, Makoto Nagai, Tetsuya Mizutani
We tested usefulness of a target enrichment system SureSelect, a comprehensive viral nucleic acid detection method, for rapid identification of viral pathogens in feces samples of cattle, pigs and goats. This system enriches nucleic acids of target viruses in clinical/field samples by using a library of biotinylated RNAs with sequences complementary to the target viruses. The enriched nucleic acids are amplified by PCR and subjected to next generation sequencing to identify the target viruses. In many samples, SureSelect target enrichment method increased efficiencies for detection of the viruses listed in the biotinylated RNA library...
December 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29217788/complete-genome-sequences-of-two-human-parainfluenza-virus-type-3-isolates-collected-in-brazil
#3
Nicholas Di Paola, Marielton Dos Passos Cunha, Giuliana Stravinskas Durigon, Eitan Naaman Berezin, Edison Durigon, Danielle Bruna Leal de Oliveira, Paolo Marinho de Andrade Zanotto
Here, we present the complete genome sequences of two human parainfluenza virus type 3 (HPIV-3) isolates collected from hospitalized infants suffering from acute respiratory disease. These are the first complete genome sequences of HPIV-3 originating from Brazil.
December 7, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29215584/a-positive-control-for-detection-of-functional-cd4-t-cells-in-pbmc-the-cpi-pool
#4
Annemarie Schiller, Ting Zhang, Ruliang Li, Andrea Duechting, Srividya Sundararaman, Anna Przybyla, Stefanie Kuerten, Paul V Lehmann
Testing of peripheral blood mononuclear cells (PBMC) for immune monitoring purposes requires verification of their functionality. This is of particular concern when the PBMC have been shipped or stored for prolonged periods of time. While the CEF (Cytomegalo-, Epstein-Barr and Flu-virus) peptide pool has become the gold standard for testing CD8 cell functionality, a positive control for CD4 cells is so far lacking. The latter ideally consists of proteins so as to control for the functionality of the antigen processing and presentation compartments, as well...
December 7, 2017: Cells
https://www.readbyqxmd.com/read/29212701/multicenter-evaluation-of-the-eplex%C3%A2-respiratory-pathogen-panel-for-the-detection-of-viral-and-bacterial-respiratory-tract-pathogens-in-nasopharyngeal-swabs
#5
N Esther Babady, Matthew R England, Kristen L Jurcic Smith, Taojun He, Dona Saumya Wijetunge, Yi-Wei Tang, Robin R Chamberland, Marilyn Menegus, Ella M Swierkosz, Robert C Jerris, Wallace Greene
Background: The performance of the new ePlex® Respiratory Pathogen (RP) Panel (GenMark Diagnostics) for the simultaneous detection of 19 viruses (influenza A, influenza A H1, influenza A 2009 H1, influenza A H3, influenza B, adenovirus, coronaviruses [HKU1, OC43, NL63, 229E], human rhinovirus/enterovirus, human metapneumovirus, parainfluenza viruses 1, 2, 3 and 4, respiratory syncytial virus (RSV) [RSVA and RSV B]) and two bacteria (Mycoplasma pneumoniae and Chlamydia pneumoniae) was evaluated.Methods: Prospectively and retrospectively collected nasopharyngeal swab (NPS) specimens (n =2,908) were evaluated using the ePlex RP Panel with the bioMérieux/BioFire FilmArray® Respiratory Panel (BF RP) as the comparator method...
December 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29212531/etiology-of-respiratory-tract-infections-in-the-community-and-clinic-in-ilorin-nigeria
#6
Olatunji Kolawole, Michael Oguntoye, Tina Dam, Rumi Chunara
OBJECTIVE: Recognizing increasing interest in community disease surveillance globally, the goal of this study was to investigate whether respiratory viruses circulating in the community may be represented through clinical (hospital) surveillance in Nigeria. RESULTS: Children were selected via convenience sampling from communities and a tertiary care center (n = 91) during spring 2017 in Ilorin, Nigeria. Nasal swabs were collected and tested using polymerase chain reaction...
December 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29209895/antiviral-activity-and-metal-ion-binding-properties-of-some-2-hydroxy-3-methoxyphenyl-acylhydrazones
#7
M Carcelli, E Fisicaro, C Compari, L Contardi, D Rogolino, C Solinas, A Stevaert, L Naesens
Here we report on the results obtained from an antiviral screening, including herpes simplex virus, vaccinia virus, vesicular stomatitis virus, Coxsackie B4 virus or respiratory syncytial virus, parainfluenza-3 virus, reovirus-1 and Punta Toro virus, of three 2-hydroxy-3-methoxyphenyl acylhydrazone compounds in three cell lines (i.e. human embryonic lung fibroblast cells, human cervix carcinoma cells, and African Green monkey kidney cells). Interesting antiviral EC50 values are obtained against herpes simplex virus-1 and vaccinia virus...
December 5, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29208015/molecular-etiological-profile-of-atypical-bacterial-pathogens-viruses-and-coinfections-among-infants-and-children-with-community-acquired-pneumonia-admitted-to-a-national-hospital-in-lima-peru
#8
Juana Del Valle-Mendoza, Wilmer Silva-Caso, Angela Cornejo-Tapia, Fiorella Orellana-Peralta, Eduardo Verne, Claudia Ugarte, Miguel Angel Aguilar-Luis, María Del Carmen De Lama-Odría, Ronald Nazario-Fuertes, Mónica Esquivel-Vizcarra, Verónica Casabona-Ore, Pablo Weilg, Luis J Del Valle
OBJECTIVE: The main objective of this study was to detect the presence of 14 respiratory viruses and atypical bacteria (Mycoplasma pneumoniae, Chlamydia pneumoniae), via polymerase chain reaction in patients under 18 years old hospitalized due to community-acquired pneumonia (CAP) from Lima, Peru. RESULTS: Atypical pathogens were detected in 40% (58/146); viral etiologies in 36% (52/146) and coinfections in 19% (27/146). The most common etiological agent was M...
December 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29204302/parainfluenza-3-respiratory-infection-associated-with-pericardial-effusion-in-a-very-low-birthweight-infant
#9
Cristina Aranda Cazón, Luis Arruza Gómez, Gloria Herranz Carrillo, Cristina González Menchén, Zarife Daoud Pérez, José Antonio Martínez-Orgado, José Tomás Ramos Amador
Parainfluenza 3 virus is a frequent cause of respiratory infections in the pediatric population although it is uncommonly diagnosed in neonates, being usually reported as neonatal intensive care unit microepidemics. We report a case of parainfluenza 3 respiratory infection associated with pericardial effusion in a very low birthweight infant.
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29196954/prevalence-of-human-parainfluenza-viruses-and-noroviruses-genomes-on-office-fomites
#10
Agata Stobnicka, Małgorzata Gołofit-Szymczak, Angelina Wójcik-Fatla, Violetta Zając, Joanna Korczyńska-Smolec, Rafał L Górny
The aim of this study was to evaluate the potential role of office fomites in respiratory (human parainfluenza virus 1-HPIV1, human parainfluenza virus 3-HPIV3) and enteric (norovirus GI-NoV GI, norovirus GII-NoV GII) viruses transmission by assessing the occurrence of these viruses on surfaces in office buildings. Between 2016 and 2017, a total of 130 surfaces from open-space and non-open-space rooms in office buildings located in one city were evaluated for HPIV1, HPIV3, NoV GI, and NoV GII viral RNA presence...
December 1, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/29189528/incidence-and-diagnostic-evaluation-of-postoperative-fever-in-pediatric-patients-with-neuromuscular-disorders
#11
Mohamed A A Yousef, Darius Dranginis, Scott Rosenfeld
BACKGROUND: Children with neuromuscular disorders have a significant chance of developing scoliosis and/or hip dislocation during childhood and adolescence and often undergo surgical reconstruction. Because of their high rate of medical comorbidities, these patients are at higher risk of postoperative complications and are therefore often comanaged, along with orthopaedics, by pediatric medicine and critical care teams. Fever during the postoperative stay is a frequent occurrence and often prompts extensive diagnostic workup which increases the cost and burden on the health system but have unclear effects on the care of the patient...
November 16, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29187536/inflammasome-antagonism-by-human-parainfluenza-virus-type-3-c-protein
#12
Niraj K Shil, Swechha M Pokharel, Amiya K Banerjee, Michael Hoffman, Santanu Bose
Human parainfluenza virus type 3 (HPIV3) is a negative-sense single-stranded RNA virus belonging to the paramyxoviridae family. HPIV3 is a lung tropic virus causing airway diseases including pneumonia, croup, and bronchiolitis during infancy and childhood. Activation of inflammasome by pathogens results in production of pro-inflammatory cytokines like IL-1β during infection. Thus, inflammasome mediated pro-inflammatory response plays a critical role in regulating immune response and virus clearance. Inflammasome is a multimeric protein complex triggering caspase-1 activation...
November 29, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29186956/how-viruses-infiltrate-the-central-nervous-system
#13
A Michalicová, K Bhide, M Bhide, A Kováč
Central nervous system is protected by the blood-brain barrier, which represents a physical, metabolic and transport barrier and is considered to be a part of a highly dynamic system termed neurovascular unit. Several pathogens, among them viruses, are able to invade the brain. Traversal of viruses across the blood-brain barrier is an essential step for the invasion of the central nervous system and can occur by different mechanisms - by paracellular, transcellular and/or by "Trojan horse" pathway. Penetration of viruses to brain can lead to the blood-brain barrier dysfunction, including increased permeability, pleocytosis and encephalopathy...
2017: Acta Virologica
https://www.readbyqxmd.com/read/29173585/european-surveillance-of-emerging-pathogens-associated-with-canine-infectious-respiratory-disease
#14
Judy A Mitchell, Jacqueline M Cardwell, Heather Leach, Caray A Walker, Sophie Le Poder, Nicola Decaro, Miklos Rusvai, Herman Egberink, Peter Rottier, Mireia Fernandez, Eirini Fragkiadaki, Shelly Shields, Joe Brownlie
Canine infectious respiratory disease (CIRD) is a major cause of morbidity in dogs worldwide, and is associated with a number of new and emerging pathogens. In a large multi-centre European study the prevalences of four key emerging CIRD pathogens; canine respiratory coronavirus (CRCoV), canine pneumovirus (CnPnV), influenza A, and Mycoplasma cynos (M. cynos); were estimated, and risk factors for exposure, infection and clinical disease were investigated. CIRD affected 66% (381/572) of the dogs studied, including both pet and kennelled dogs...
December 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29153777/vaccination-with-a-human-parainfluenza-virus-type-3-chimeric-fhn-glycoprotein-formulated-with-a-combination-adjuvant-induces-protective-immunity
#15
R Garg, R Brownlie, L Latimer, V Gerdts, A Potter, S van Drunen Littel-van den Hurk
Human parainfluenza virus type 3 (PIV3) is a major cause of lower respiratory disease i.e. bronchitis, bronchiolitis or pneumonia, in infants and young children. Presently there is no licensed vaccine against PIV3. To produce an effective subunit vaccine, a chimeric FHN glycoprotein consisting of the N-terminal ectodomain of the fusion (F) protein linked to the haemagglutinin-neuraminidase (HN) protein without transmembrane domain, and secreted forms of the individual F and HN glycoproteins, were expressed in mammalian cells and purified...
November 16, 2017: Vaccine
https://www.readbyqxmd.com/read/29149199/epidemiology-and-clinical-profile-of-pathogens-responsible-for-the-hospitalization-of-children-in-sousse-area-tunisia
#16
Ines Brini, Aida Guerrero, Naila Hannachi, Jihene Bouguila, Dorothea Orth-Höller, Amira Bouhlel, Lamia Boughamoura, Benjamin Hetzer, Wegene Borena, Britta Schiela, Dorothee Von Laer, Jalel Boukadida, Heribert Stoiber
This study aimed to identify a broad spectrum of respiratory pathogens from hospitalized and not-preselected children with acute respiratory tract infections in the Farhat Hached University-hospital of Sousse, Tunisia. Between September 2013 and December 2014, samples from 372 children aged between 1 month and 5 years were collected, and tested using multiplex real-time RT-PCR by a commercial assay for 21 respiratory pathogens. In addition, samples were screened for the presence of Streptococcus pneumoniae 16S rDNA using real-time PCR...
2017: PloS One
https://www.readbyqxmd.com/read/29143374/asthma-and-lung-function-in-adulthood-after-a-viral-wheezing-episode-in-early-childhood
#17
Katri Backman, Hertta Ollikainen, Eija Piippo-Savolainen, Kirsi Nuolivirta, Matti Korppi
BACKGROUND: Viral etiology of infection has a significant role in the long-term outcome of early-childhood wheezing. OBJECTIVE: This study examines asthma and lung function in adulthood after early-childhood wheezing induced by respiratory syncytial virus (RSV) and rhinovirus (RV). METHODS: A total of 100 children were hospitalized for a wheezing episode at less than 24 months of age from 1992 to 1993 in Kuopio University Hospital (Finland)...
November 16, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29131392/virus-detection-in-critically-ill-children-with-acute-respiratory-disease-a-new-profile-in-view-of-new-technology
#18
Atsushi Kawaguchi, Angela Bates, Bonita E Lee, Steven Drews, Daniel Garros
AIM: To describe the epidemiology of critically ill children admitted to a pediatric intensive care unit (PICU) with acute respiratory disease. The association with intubation was analyzed for the three most prevalent viruses and in those with and without viral co-infection. METHODS: Patients admitted to the PICU (2004 - 2014) with acute respiratory disease were included. Analyses were performed utilizing each respiratory viral infection or multiple viral infections as an exposure...
November 13, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29128020/respiratory-viral-infections-in-solid-organ-and-hematopoietic-stem-cell-transplantation
#19
REVIEW
Grant C Paulsen, Lara Danziger-Isakov
Respiratory viruses are common in solid organ and hematopoietic stem cell transplant recipients and a recognized cause of significant morbidity and mortality. Epidemiology, risk factors, and attributable mortality in both populations are reviewed. In addition, virus-specific prevention and treatment options, including emerging investigational therapies, are discussed for respiratory syncytial virus, influenza, adenovirus, parainfluenza, and other respiratory viruses.
December 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29127946/seasonal-trends-of-diagnosis-of-childhood-malignant-diseases-and-viral-prevalence-in-south-korea
#20
Kyu Seok Shim, Min Hyung Kim, Choong Nam Shim, Minkyu Han, In Seok Lim, Soo Ahn Chae, Sin Weon Yun, Na Mi Lee, Dae Yong Yi, Hyery Kim
BACKGROUND: Several studies have reported a seasonal trend in the diagnosis of childhood cancer suggesting seasonal factors such as infection. The present study aimed to analyze the diagnosis pattern of childhood malignant diseases using public health data, and to compare this pattern with seasonal viral infection trends. METHOD: Using the open data source of the Health Insurance Review and Assessment Service, we extracted data regarding all patients under 21 years of age and who had any cancer, aplastic anemia or myelodysplastic syndrome between September 2009 and December 2013...
November 8, 2017: Cancer Epidemiology
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