keyword
MENU ▼
Read by QxMD icon Read
search

'Brain perfusion'

keyword
https://www.readbyqxmd.com/read/29116145/cingulate-island-sign-temporally-changes-in-dementia-with-lewy-bodies
#1
Tomomichi Iizuka, Rui Iizuka, Masashi Kameyama
The cingulate island sign (CIS) that reflects sparing of the posterior cingulate cortex (PCC) relative to the precuneus plus cuneus on FDG-PET and brain perfusion SPECT, has been proposed as a feature of dementia with Lewy bodies (DLB). As the CIS is influenced by concomitant Alzheimer's disease (AD)-type neurofibrillary tangle (NFT) pathology, we postulated that the CIS gradually disappears as DLB progresses. To determine temporal changes in the CIS, 24 patients with mild DLB and 7 with prodromal DLB underwent (123)I-IMP-SPECT and MMSE twice at an interval of two years...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29100664/tyrosine-hydroxylase-in-the-ventral-tegmental-area-of-rams-with-high-or-low-libido-a-role-for-dopamine
#2
A C Kramer, A J Mirto, K J Austin, C E Roselli, B M Alexander
Dopamine synthesis in the ventral tegmental area (VTA) is necessary for the reinforcement of sexual behavior. The objective of this study determined if sexual stimuli initiates reward, and whether reward is attenuated in sexually inactive rams. Sexually active rams were exposed to urine from estrous (n=4) or ovariectomized (n=3) ewes with inactive rams (n=3) exposed to urine from estrous ewes. Following exposure, rams were exsanguinated and brains perfused. Alternating sections of the VTA were stained for Fos related antigens (FRA), tyrosine hydroxylase, and dopamine beta-hydroxylase activity...
October 31, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29090331/differentiation-of-grade-ii-iii-and-grade-iv-glioma-by-combining-t1-contrast-enhanced-brain-perfusion-imaging-and-susceptibility-weighted-quantitative-imaging
#3
Jitender Saini, Pradeep Kumar Gupta, Prativa Sahoo, Anup Singh, Rana Patir, Suneeta Ahlawat, Manish Beniwal, K Thennarasu, Vani Santosh, Rakesh Kumar Gupta
PURPOSE: MRI is a useful method for discriminating low- and high-grade glioma using perfusion MRI and susceptibility-weighted imaging (SWI). The purpose of this study is to evaluate the usefulness of T1-perfusion MRI and SWI in discriminating among grade II, III, and IV gliomas. METHODS: T1-perfusion MRI was used to measure relative cerebral blood volume (rCBV) in 129 patients with glioma (70 grade IV, 33 grade III, and 26 grade II tumors). SWI was also used to measure the intratumoral susceptibility signal intensity (ITSS) scores for each tumor in these patients...
October 31, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29090274/a-novel-lrp1-binding-peptide-l57-that-crosses-the-blood-brain-barrier
#4
Kotaro Sakamoto, Tokuyuki Shinohara, Yusuke Adachi, Taiji Asami, Tetsuya Ohtaki
The blood-brain barrier (BBB) is a major obstacle to drug delivery into the central nervous system (CNS), in particular for macromolecules such as peptides and proteins. However, certain macromolecules can reach the CNS via a receptor-mediated transcytosis (RMT) pathway, and low-density lipoprotein receptor-related protein 1 (LRP1) is one of the promising receptors for RMT. An LRP1 ligand peptide, Angiopep-2, was reported to pass through the BBB and deliver covalently conjugated drugs into the CNS. While conjugation of LRP1 ligands with drugs would be an effective approach for drug delivery to the CNS, no other reliable LRP1 ligands have been reported to date...
December 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29083523/mri-of-plaque-characteristics-and-relationship-with-downstream-perfusion-and-cerebral-infarction-in-patients-with-symptomatic-middle-cerebral-artery-stenosis
#5
Shan-Shan Lu, Song Ge, Chun-Qiu Su, Jun Xie, Jian Mao, Hai-Bin Shi, Xun-Ning Hong
BACKGROUND: Intracranial plaque characteristics are associated with stroke events. Differences in plaque features may explain the disconnect between stenosis severity and the presence of ischemic stroke. PURPOSE: To investigate the relationship between plaque characteristics and downstream perfusion changes, and their contribution to the occurrence of cerebral infarction beyond luminal stenosis. STUDY TYPE: Case control. SUBJECTS: Forty-six patients with symptomatic middle cerebral artery (MCA) stenosis (with acute cerebral infarction, n = 30; without acute cerebral infarction, n = 16)...
October 30, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29082864/fitness-to-drive-in-cardiovascular-disease
#6
Hermann H Klein, Udo Sechtem, Hans-Joachim Trappe
BACKGROUND: Medical students are taught little or nothing about the medical considerations related to the driving of motor vehicles. Physicians treating patients with cardiovascular disease need to acquire competence in traffic medicine in order to be able to advise them about their fitness to drive. METHODS: We present the current governmental regulations and recommendations concerning fitness to drive in patients with cardiovascular disease. We also review pertinent publications that were retrieved by a selective search in PubMed with the search terms "cardiovascular disease and traffic accidents" and "cardiovascular disease and traffic deaths" for the decade 2007-2016, as well as further publications collected by us individually...
October 13, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29016776/atrial-fibrillation-is-associated-with-decreased-total-cerebral-blood-flow-and-brain-perfusion
#7
Marianna Gardarsdottir, Sigurdur Sigurdsson, Thor Aspelund, Hrafnhildur Rokita, Lenore J Launer, Vilmundur Gudnason, David O Arnar
Aims: Atrial fibrillation (AF) has been associated with cognitive impairment. Additionally, brain volume may be reduced in individuals with AF. Potential causes may include cerebral micro-embolism or reduced stroke volume due to the beat-to-beat variation in AF. The aims of this study were to measure cerebral blood flow and estimate whole brain perfusion in elderly individuals with and without AF. Methods and results: Blood flow in the cervical arteries was measured with phase contrast MRI and brain perfusion estimated in a large cohort from the AGES-Reykjavik Study...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28982786/preoperative-cerebral-oxygen-extraction-fraction-imaging-generated-from-7t-mr-quantitative-susceptibility-mapping-predicts-development-of-cerebral-hyperperfusion-following-carotid-endarterectomy
#8
J-I Nomura, I Uwano, M Sasaki, K Kudo, F Yamashita, K Ito, S Fujiwara, M Kobayashi, K Ogasawara
BACKGROUND AND PURPOSE: Preoperative hemodynamic impairment in the affected cerebral hemisphere is associated with the development of cerebral hyperperfusion following carotid endarterectomy. Cerebral oxygen extraction fraction images generated from 7T MR quantitative susceptibility mapping correlate with oxygen extraction fraction images on positron-emission tomography. The present study aimed to determine whether preoperative oxygen extraction fraction imaging generated from 7T MR quantitative susceptibility mapping could identify patients at risk for cerebral hyperperfusion following carotid endarterectomy...
October 5, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28980775/long-term-recovery-after-endothelial-colony-forming-cells-or-human-umbilical-cord-blood-cells-administration-in-a-rat-model-of-neonatal-hypoxic-ischemic-encephalopathy
#9
Isabelle Grandvuillemin, Philippe Garrigue, Alaa Ramdani, Farid Boubred, Umberto Simeoni, Françoise Dignat-George, Florence Sabatier, Benjamin Guillet
Neonatal hypoxic-ischemic encephalopathy (NHIE) is a dramatic perinatal complication, associated with poor neurological prognosis despite neuroprotection by therapeutic hypothermia, in the absence of an available curative therapy. We evaluated and compared ready-to-use human umbilical cord blood cells (HUCBC) and bankable but allogeneic endothelial progenitors (ECFC) as cell therapy candidate for NHIE. We compared benefits of HUCBC and ECFC transplantation 48 hours after injury in male rat NHIE model, based on the Rice-Vannucci approach...
November 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28971638/computed-tomography-perfusion-maps-reveal-blood-flow-dynamics-in-postictal-patients-a-novel-diagnostic-tool
#10
Shahar Shelly, Nicola Maggio, Marina Boxer, Ilan Blatt, David Tanne, David Orion
BACKGROUND: Computed tomography (CT) brain perfusion is a relatively new imaging method that can be used to differentiate patients following epileptic seizures in the setting of acute neurological deficits (e.g., hemiparesis, hemiplegia, hemianopsia, aphasia) who arrive at the emergency room with a suspected stroke. OBJECTIVES: To evaluate brain perfusion changes in patients who had an epileptic seizure. METHODS: We retrospectively identified 721 patients who presented at our stroke center between 2012 and 2015 with a suspected acute stroke and underwent examination thorough a stroke protocol, including cerebral CT perfusion (CTP) and CT angiography (CTA) within 8 hours from the onset of symptoms...
September 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28962207/whole-brain-ct-perfusion-imaging-using-increased-sampling-intervals-a-pilot-study
#11
Guoquan Cao, Weijian Chen, Houzhang Sun, Xianzhong Guo, Yunjun Yang, Kun Tang, Jinjin Liu
The aim of the present study was to investigate the feasibility of whole-brain perfusion imaging using the increased sampling interval protocol for 320-detector row dynamic-volume computed tomography (CT). A total of 12 volunteers were recruited. The novel protocols with 11 volumes (defined as protocol P11) and 15 volumes (defined as protocol P15) were performed on the volunteers to evaluate whether P11 and P15 are able to acquire comparable results to the standard protocol with 19 volumes (defined as protocol P19) according to the as-low-as-reasonably-achievable principle...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28958044/altered-regional-cerebral-blood-flow-in-idiopathic-hypersomnia
#12
Soufiane Boucetta, Jacques Montplaisir, Antonio Zadra, Francis Lachapelle, Jean-Paul Soucy, Paul Gravel, Thien Thanh Dang-Vu
Objectives: Idiopathic hypersomnia is characterized by excessive daytime sleepiness despite normal or long sleep time. Its pathophysiological mechanisms remain unclear. This pilot study aims at characterizing the neural correlates of idiopathic hypersomnia using single photon emission computed tomography. Methods: Thirteen participants with idiopathic hypersomnia and sixteen healthy controls were scanned during resting wakefulness using a high-resolution single photon emission computed tomography scanner with 99mTc-ethyl cysteinate dimer to assess cerebral blood flow...
August 23, 2017: Sleep
https://www.readbyqxmd.com/read/28936173/combining-spect-and-quantitative-eeg-analysis-for-the-automated-differential-diagnosis-of-disorders-with-amnestic-symptoms
#13
Yvonne Höller, Arne C Bathke, Andreas Uhl, Nicolas Strobl, Adelheid Lang, Jürgen Bergmann, Raffaele Nardone, Fabio Rossini, Harald Zauner, Margarita Kirschner, Amirhossein Jahanbekam, Eugen Trinka, Wolfgang Staffen
Single photon emission computed tomography (SPECT) and Electroencephalography (EEG) have become established tools in routine diagnostics of dementia. We aimed to increase the diagnostic power by combining quantitative markers from SPECT and EEG for differential diagnosis of disorders with amnestic symptoms. We hypothesize that the combination of SPECT with measures of interaction (connectivity) in the EEG yields higher diagnostic accuracy than the single modalities. We examined 39 patients with Alzheimer's dementia (AD), 69 patients with depressive cognitive impairment (DCI), 71 patients with amnestic mild cognitive impairment (aMCI), and 41 patients with amnestic subjective cognitive complaints (aSCC)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28917591/increased-left-prefrontal-brain-perfusion-after-mri-compatible-tdcs-attenuates-momentary-ruminative-self-referential-thoughts
#14
Chris Baeken, Jonathan Remue, Marie-Anne Vanderhasselt, Andre R Brunoni, Sara De Witte, Romain Duprat, Ernst H W Koster, Rudi De Raedt, Guo-Rong Wu
BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive electrical stimulation technique, assumed to influence cognition and emotional processing. OBJECTIVE: However, it is unclear how tDCS influences spontaneous cognitive processes such as momentary self-referential thoughts on the neuronal level. METHODS: Forty healthy female volunteers participated in a single session sham-controlled crossover tDCS study while being in the MRI scanner...
September 6, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28913751/emergency-neurological-life-support-airway-ventilation-and-sedation
#15
Venkatakrishna Rajajee, Becky Riggs, David B Seder
Airway management and ventilation are central to the resuscitation of the neurologically ill. These patients often have evolving processes that threaten the airway and adequate ventilation. Furthermore, intubation, ventilation, and sedative choices directly affect brain perfusion. Therefore, Airway, Ventilation, and Sedation was chosen as an Emergency Neurological Life Support protocol. Topics include airway management, when and how to intubate with special attention to hemodynamics and preservation of cerebral blood flow, mechanical ventilation settings and the use of sedative agents based on the patient's neurological status...
September 14, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28912128/aging-modifies-the-effect-of-cardiac-output-on-middle-cerebral-artery-blood-flow-velocity
#16
Anne-Sophie G T Bronzwaer, Jasper Verbree, Wim J Stok, Mat J A P Daemen, Mark A van Buchem, Matthias J P van Osch, Johannes J van Lieshout
An association between cerebral blood flow (CBF) and cardiac output (CO) has been established in young healthy subjects. As of yet it is unclear how this association evolves over the life span. To that purpose, we continuously recorded mean arterial pressure (MAP; finger plethysmography), CO (pulse contour; CO-trek), mean blood flow velocity in the middle cerebral artery (MCAV; transcranial Doppler ultrasonography), and end-tidal CO2 partial pressure (PetCO2) in healthy young (19-27 years), middle-aged (51-61 years), and elderly subjects (70-79 years)...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28906268/new-pet-markers-for-the-diagnosis-of-dementia
#17
Pierre Payoux, Anne Sophie Salabert
PURPOSE OF REVIEW: To present the new PET markers that could become in the coming years, relevant to advanced clinical approaches to dementia diagnosis, drug trials, and treatment strategies and discuss their advantages and limitations. RECENT FINDINGS: The most advanced new PET tracers are the markers of the amyloid plaques, the τ compounds and the tracers of the translocator protein as markers of neuroinflammation. The main advantages but also the weaknesses of each of these markers are discussed...
September 12, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28888042/effect-of-a-multinutrient-intervention-after-ischemic-stroke-in-female-c57bl-6-mice
#18
Maximilian Wiesmann, Nienke M Timmer, Bastian Zinnhardt, Dirk Reinhard, Sarah Eligehausen, Anja Königs, Hasnae Ben Jeddi, Pieter J Dederen, Andreas H Jacobs, Amanda J Kiliaan
Stroke can affect females very differently from males, and therefore preclinical research on underlying mechanisms and the effects of interventions should not be restricted to male subjects, and treatment strategies for stroke should be tailored to benefit both sexes. Previously, we demonstrated that a multinutrient intervention (Fortasyn) improved impairments after ischemic stroke induction in male C57Bl/6 mice, but the therapeutic potential of this dietary treatment remained to be investigated in females...
September 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28880164/low-dose-dynamic-cerebral-perfusion-computed-tomography-reconstruction-via-kronecker-basis-representation-tensor-sparsity-regularization
#19
Jianhua Ma, Qi Xie, Wenfei Cao, Jiahui Lin, Hao Zhang, Shanli Zhang, Jing Huang, Zhaoying Bian, Deyu Meng, Zongben Xu, Zhengrong Liang, Wufan Chen, Dong Zeng
Dynamic cerebral perfusion computed tomography (DCPCT) has the ability to evaluate the hemodynamic information throughout the brain. However, due to multiple threedimensional image volume acquisitions protocol, DCPCT scanning imposes high radiation dose on the patients with growing concerns. To address this issue, in this study, based on the robust principal component analysis (RPCA, or equivalently the low-rank and sparsity decomposition) model and the DCPCT imaging procedure, we propose a new DCPCT image reconstruction algorithm to improve low-dose DCPCT and perfusion maps quality via using a powerful measure, called Kroneckerbasis- representation (KBR) tensor sparsity regularization, for measuring low-rankness extent of a tensor...
September 4, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28879204/dynamic-susceptibility-contrast-perfusion-magnetic-resonance-imaging-demonstrates-reduced-periventricular-cerebral-blood-flow-in-dogs-with-ventriculomegaly
#20
Martin J Schmidt, Malgorzata Kolecka, Robert Kirberger, Antje Hartmann
The nature of ventriculomegaly in dogs is still a matter of debate. Signs of increased intraventricular pressure and atrophy of the cerebral white matter have been found in dogs with ventriculomegaly, which would imply increased intraventricular pressure and, therefore, a pathological condition, i.e., to some extent. Reduced periventricular blood flow was found in people with high elevated intraventricular pressure. The aim of this study was to compare periventricular brain perfusion in dogs with and without ventriculomegaly using perfusion weighted-magnetic-resonance-imaging to clarify as to whether ventriculomegaly might be associated with an increase in intraventricular pressure...
2017: Frontiers in Veterinary Science
keyword
keyword
23509
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"