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https://www.readbyqxmd.com/read/28107416/validation-of-a-modified-child-turcotte-pugh-classification-system-utilizing-insulin-like-growth-factor-1-for-patients-with-hepatocellular-carcinoma-in-an-hbv-endemic-area
#1
Dong Hyeon Lee, Jeong-Hoon Lee, Yong Jin Jung, Jungsoo Gim, Won Kim, Byeong Gwan Kim, Kook Lae Lee, Yuri Cho, Jeong-Ju Yoo, Minjong Lee, Young Youn Cho, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon
BACKGROUND: Recently, a modified insulin-like growth factor-1 (IGF)-Child-Turcotte-Pugh (CTP) classification was proposed to improve the original CTP classification. This study aimed to validate the new IGF-CTP classification system as a prognostic maker for patients with hepatocellular carcinoma (HCC) in a hepatitis B virus endemic area. METHODS: We conducted a post-hoc analysis of a prospective cohort study. We used Harrell's C-index and U-statistics to compare the prognostic performance of both IGF-CTP and CTP classifications for overall survival...
2017: PloS One
https://www.readbyqxmd.com/read/28089233/epicardial-adipose-tissue-and-myocardial-ischemia-assessed-by-computed-tomography-perfusion-imaging-and-invasive-fractional-flow-reserve
#2
Rahul G Muthalaly, Nitesh Nerlekar, Dennis T L Wong, James D Cameron, Sujith K Seneviratne, Brian S Ko
BACKGROUND: Epicardial adipose tissue (EAT) is a metabolically active fat depot that is associated with incident coronary artery disease (CAD) and major adverse cardiovascular events. The relationship between EAT and myocardial ischemia remains unclear. This study investigated the relationship between EAT volume and the presence of perfusion defects on myocardial computed tomographic perfusion imaging (CTP) and functional stenoses on invasive fractional flow-reserve (FFR). METHODS: Data were obtained from a previous prospective cross-sectional study in patients with suspected CAD...
December 30, 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28086792/irish-general-practitioner-attitudes-toward-decriminalisation-and-medical-use-of-cannabis-results-from-a-national-survey
#3
Des Crowley, Claire Collins, Ide Delargy, Eamon Laird, Marie Claire Van Hout
BACKGROUND: Governmental debate in Ireland on the de facto decriminalisation of cannabis and legalisation for medical use is ongoing. A cannabis-based medicinal product (Sativex®) has recently been granted market authorisation in Ireland. This unique study aimed to investigate Irish general practitioner (GP) attitudes toward decriminalisation of cannabis and assess levels of support for use of cannabis for therapeutic purposes (CTP). METHODS: General practitioners in the Irish College of General Practitioner (ICGP) database were invited to complete an online survey...
January 13, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28077270/instructions-to-suppress-semantic-memory-enhances-or-has-no-effect-on-p300-in-a-concealed-information-test-cit
#4
J Peter Rosenfeld, Anne Ward, Jesse Drapekin, Elena Labkovsky, Samuel Tullman
The present study investigated the extent to which people can suppress semantic memory as indexed with the P300 ERP and the autobiographical implicit association test (aIAT). In EXP 1, participants (22) were run in a counterbalanced repeated measures study in both simply knowledgeable (SK) and knowledgeable with suppression (SP) conditions. A P300-based, concealed information test ("Complex Trial Protocol"; CTP) with a 50/50 Target/Nontarget (T/NT) ratio was given both with and without instructions to suppress semantic memories...
January 7, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28073944/a-novel-bifunctional-transcriptional-regulator-of-riboflavin-metabolism-in-archaea
#5
Irina A Rodionova, Matthew W Vetting, Xiaoqing Li, Steven C Almo, Andrei L Osterman, Dmitry A Rodionov
Riboflavin (vitamin B2) is the precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide, which are essential coenzymes in all free-living organisms. Riboflavin biosynthesis in many Bacteria but not in Archaea is controlled by FMN-responsive riboswitches. We identified a novel bifunctional riboflavin kinase/regulator (RbkR), which controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain...
January 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28068143/adaptations-to-excess-choline-in-insulin-resistant-and-pcyt2-deficient-skeletal-muscle
#6
Adrian Taylor, Laila Cigana Schenkel, Maiya Yokich, Marica Bakovic
It was hypothesized that choline supplementation in insulin resistant (IR) CTP:phosphoethanolamine cytidylyltransferase deficient (Pcyt2(+/-)) mice would ameliorate muscle function by remodeling glucose and fatty acid (FA) metabolism. Pcyt2(+/-) mice either received no treatment or were allowed access to 2 mg/mL choline in drinking water for 4 weeks. Skeletal muscle was harvested from choline treated and untreated mice. Lipid analysis and metabolic gene expression and signaling pathways were compared between untreated Pcyt2(+/-) mice, treated Pcyt2(+/-) mice, and Pcyt2(+/+) mice...
September 6, 2016: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28067901/targeting-samhd1-with-the-vpx-protein-to-improve-cytarabine-therapy-for-hematological-malignancies
#7
Nikolas Herold, Sean G Rudd, Linda Ljungblad, Kumar Sanjiv, Ida Hed Myrberg, Cynthia B J Paulin, Yaser Heshmati, Anna Hagenkort, Juliane Kutzner, Brent D G Page, José M Calderón-Montaño, Olga Loseva, Ann-Sofie Jemth, Lorenzo Bulli, Hanna Axelsson, Bianca Tesi, Nicholas C K Valerie, Andreas Höglund, Julia Bladh, Elisée Wiita, Mikael Sundin, Michael Uhlin, Georgios Rassidakis, Mats Heyman, Katja Pokrovskaja Tamm, Ulrika Warpman-Berglund, Julian Walfridsson, Sören Lehmann, Dan Grandér, Thomas Lundbäck, Per Kogner, Jan-Inge Henter, Thomas Helleday, Torsten Schaller
The cytostatic deoxycytidine analog cytarabine (ara-C) is the most active agent available against acute myelogenous leukemia (AML). Together with anthracyclines, ara-C forms the backbone of AML treatment for children and adults. In AML, both the cytotoxicity of ara-C in vitro and the clinical response to ara-C therapy are correlated with the ability of AML blasts to accumulate the active metabolite ara-C triphosphate (ara-CTP), which causes DNA damage through perturbation of DNA synthesis. Differences in expression levels of known transporters or metabolic enzymes relevant to ara-C only partially account for patient-specific differential ara-CTP accumulation in AML blasts and response to ara-C treatment...
January 9, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28061757/comparison-of-risk-adjustment-methods-in-patients-with-liver-disease-using-electronic-medical-record-data
#8
Yuan Xu, Ning Li, Mingshan Lu, Elijah Dixon, Robert P Myers, Rachel J Jolley, Hude Quan
BACKGROUND: Risk adjustment is essential for valid comparison of patients' health outcomes or performances of health care providers. Several risk adjustment methods for liver diseases are commonly used but the optimal approach is unknown. This study aimed to compare the common risk adjustment methods for predicting in-hospital mortality in cirrhosis patients using electronic medical record (EMR) data. METHODS: The sample was derived from Beijing YouAn hospital between 2010 and 2014...
January 7, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28056884/secondary-psychotic-features-in-refugees-diagnosed-with-post-traumatic-stress-disorder-a-retrospective-cohort-study
#9
Mette Nygaard, Charlotte Sonne, Jessica Carlsson
BACKGROUND: A substantial amount of refugees (10-30%) suffer from Post-Traumatic Stress Disorder (PTSD). In Denmark there are different facilities specialised in psychiatric treatment of trauma-affected refugees. A previously published case report from such a facility in Denmark shows that some patients suffer from secondary psychotic symptoms alongside their PTSD. The aim of this study was to illustrate the characteristics and estimate the prevalence of psychotic features in a clinical population of trauma-affected refugees with PTSD...
January 5, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28047859/th-ab-207a-10-sub-msv-cerebral-ct-perfusion-imaging-using-prior-image-constrained-compressed-sensing-a-prospective-clinical-trial
#10
K Li, P Yang, M Cathey, J Tang, H Rowley, P Turski, V Prabhakaran, C Strother, G-H Chen
PURPOSE: A prospective clinical study was conducted to assess whether sub-mSv cerebral CT perfusion (CTP) imaging can be achieved using the Prior Image Constrained Compressed Sensing (PICSS) reconstruction algorithm. METHODS: Following a standard dose (SD) CTP acquisition, 31 patients (median age, 62 years; 15 M/16 F; median BMI, 27) underwent an additional reduced dose (RD) CTP acquisition at 20% of the standard dose level. Several algorithms (PICCS, ASIR, and FBP) were used to reconstruct CTP source images of the RD series...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047431/su-f-r-51-radiomics-in-ct-perfusion-maps-of-head-and-neck-cancer
#11
M Nesteruk, O Riesterer, R Bundschuh, P Veit-Haibach, M Huellner, G Studer, S Stieb, S Glatz, M Pruschy, M Guckenberger, S Tanadini-Lang
PURPOSE: The aim of this study was to test the predictive value of radiomics features of CT perfusion (CTP) for tumor control, based on a preselection of radiomics features in a robustness study. METHODS: 11 patients with head and neck cancer (HNC) and 11 patients with lung cancer were included in the robustness study to preselect stable radiomics parameters. Data from 36 HNC patients treated with definitive radiochemotherapy (median follow-up 30 months) was used to build a predictive model based on these parameters...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047196/th-ab-207a-11-anatomical-and-functional-assessment-of-coronary-artery-disease-using-low-dose-whole-organ-dynamic-computed-tomography
#12
L Hubbard, B Ziemer, J Lipinski, S Malkasian, B Sadeghi, H Javan, B Dertli, E M Groves, S Molloi
PURPOSE: To evaluate the accuracy of a low-dose, first-pass-analysis (FPA) dynamic computed tomography angiography and perfusion (CTAP) technique, for whole-organ anatomical and functional assessment of coronary artery disease (CAD). METHODS: An angioplasty balloon was advanced into the left anterior descending (LAD) coronary artery of five swine (35-45 kg) to induce several levels of stenosis at maximal hyperemia (intracoronary adenosine, 240 µg/min). Reference fluorescence microspheres and intravenous contrast (370 mg/mL iodine, 25 mL, 7 mL/s) were injected centrally and dynamic imaging was performed using a 320-slice CT scanner at 100 kVp and 200 mA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046899/su-g-iep2-06-evaluation-of-registration-accuracy-for-cone-beam-ct-reconstruction-techniques
#13
J Li, H Zhang, P Wang
PURPOSE: Cone-beam (CB) computed tomography (CT) is used for image guidance during radiotherapy treatment delivery. Conventional Feldkamp and compressed sensing (CS) based CBCT recon-struction techniques are compared for image registration. This study is to evaluate the image registration accuracy of conventional and CS CBCT for head-and-neck (HN) patients. METHODS: Ten HN patients with oropharyngeal tumors were retrospectively selected. Each HN patient had one planning CT (CTP) and three CBCTs were acquired during an adaptive radiotherapy proto-col...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28018847/uncertainty-and-innovation-understanding-the-role-of-cell-based-manufacturing-facilities-in-shaping-regulatory-and-commercialization-environments
#14
Rosario Isasi, Vasiliki Rahimzadeh, Kathleen Charlebois
The purpose of this qualitative study is to elucidate stakeholder perceptions of, and institutional practices related to cell-based therapies and products (CTP) regulation and commercialization in Canada. The development of reproducible, safe and effective CTPs is predicated on regulatory and commercialization environments that enable innovation. Manufacturing processes constitute a critical step for CTP development in this regard. The road from CTP manufacturing to translation in the clinic, however, has yet to be paved...
December 2016: Applied & Translational Genomics
https://www.readbyqxmd.com/read/28011374/robust-cranial-cavity-segmentation-in-ct-and-ct-perfusion-images-of-trauma-and-suspected-stroke-patients
#15
Ajay Patel, Bram van Ginneken, Frederick J A Meijer, Ewoud J van Dijk, Mathias Prokop, Rashindra Manniesing
A robust and accurate method is presented for the segmentation of the cranial cavity in computed tomography (CT) and CT perfusion (CTP) images. The method consists of multi-atlas registration with label fusion followed by a geodesic active contour levelset refinement of the segmentation. Pre-registration atlas selection based on differences in anterior skull anatomy reduces computation time whilst optimising performance. The method was evaluated on a large clinical dataset of 573 acute stroke and trauma patients that received a CT or CTP in our hospital in the period February 2015-December 2015...
December 13, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/28009086/1-2-diacylglycerol-choline-phosphotransferase-catalyzes-the-final-step-in-the-unique-treponema-denticola-phosphatidylcholine-biosynthesis-pathway
#16
Miguel Ángel Vences-Guzmán, M Paula Goetting-Minesky, Ziqiang Guan, Santiago Castillo-Ramirez, Luz América Córdoba-Castro, Isabel M López-Lara, Otto Geiger, Christian Sohlenkamp, J Christopher Fenno
Treponema denticola synthesizes phosphatidylcholine through a licCA-dependent CDP-choline pathway identified only in the genus Treponema. However, the mechanism of conversion of CDP-choline to phosphatidylcholine remained unclear. We report here characterization of TDE0021 (herein designated cpt) encoding a 1,2-diacylglycerol choline phosphotransferase homologous to choline phosphotransferases that catalyze the final step of the highly conserved Kennedy pathway for phosphatidylcholine synthesis in eukaryotes...
December 23, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/28004509/serial-changes-of-computed-tomographic-peritoneogram-in-patients-with-symptomatic-ultrafiltration-failure-complicating-continuous-ambulatory-peritoneal-dialysis
#17
Michelle Cheung, Ferdinand Sk Chu, Lorraine Py Kwan
INTRODUCTION: It is well-known that continuous ambulatory peritoneal dialysis (CAPD) is associated with complications. And some of these complications are well-demonstrated as abnormalities on computed tomographic peritoneogram (CTP). The objective of our study is to document the serial changes of these complications. METHODS: We retrospectively reviewed 125 patients treated with CAPD for end staged renal failure (ESRF) who had CTP conducted in our hospital between December 2006 and August 2015...
December 21, 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28004117/a-blood-based-gene-expression-and-signaling-pathway-analysis-to-differentiate-between-high-and-low-grade-gliomas
#18
Stephen N Ponnampalam, Nor Rizan Kamaluddin, Zubaidah Zakaria, Vickneswaran Matheneswaran, Dharmendra Ganesan, Mohammed Saffari Haspani, Mina Ryten, John A Hardy
The aims of the present study were to undertake gene expression profiling of the blood of glioma patients to determine key genetic components of signaling pathways and to develop a panel of genes that could be used as a potential blood-based biomarker to differentiate between high and low grade gliomas, non-gliomas and control samples. In this study, blood samples were obtained from glioma patients, non-glioma and control subjects. Ten samples each were obtained from patients with high and low grade tumours, respectively, ten samples from non-glioma patients and twenty samples from control subjects...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/28003508/cigar-product-modification-among-high-school-youth
#19
Erika S Trapl, Sarah J Koopman Gonzalez, Leslie Cofie, Laura D Yoder, Jean Frank, Kymberle L Sterling
INTRODUCTION: Prevalence of cigar use has been increasing among youth. Research indicates that youth are modifying cigar products either by "freaking" (i.e. removing the filter paper) or "blunting" (removing the tobacco and supplementing or replacing with marijuana), yet little is known about youth who engage in this behavior. Thus, this study examines demographic and concurrent substance use behaviors of youth who modify cigars. METHODS: Data from the 2013 Cuyahoga County Youth Risk Behavior survey were examined (n=16855)...
December 21, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27998650/identification-of-hemodynamically-compromised-regions-by-means-of-cerebral-blood-volume-mapping-utilizing-computed-tomography-perfusion-imaging
#20
Satoshi Takahashi, Yoshio Tanizaki, Kazunori Akaji, Hiroaki Kimura, Takehiro Katano, Kentaro Suzuki, Yoichi Mochizuki, Satoka Shidoh, Masaki Nakazawa, Kazunari Yoshida, Ban Mihara
The aim of the study was to evaluate the potential role of computed tomography perfusion (CTP) imaging in identifying hemodynamically compromised regions in patients with occlusive cerebrovascular disease. Twelve patients diagnosed with either occlusion or severe stenosis of the internal carotid artery or the M1 portion of the middle cerebral artery underwent CTP imaging. The data was analyzed by an automated ROI-determining software. Patients were classified into two subgroups: an asymptomatic group consisting of three patients in whom perfusion pressure distal to the site of occlusion/stenosis (PPdis) could be maintained in spite of the arterial occlusion/stenosis, and a symptomatic group consisting of nine patients in whom PPdis could not be maintained enough to avoid watershed infarction...
December 17, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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