keyword
MENU ▼
Read by QxMD icon Read
search

CTP

keyword
https://www.readbyqxmd.com/read/29757643/peridinin-torsional-distortion-and-bond-length-alternation-introduce-intramolecular-charge-transfer-and-correlated-triplet-pair-intermediate-excited-states
#1
Elliot J Taffet, Gregory D Scholes
The nature of intramolecular charge transfer (ICT) and the mechanism of intramolecular singlet fission (SF) in peridinin remain open research questions. Obtaining an understanding of the population evolution from the bright state to dark states following a photoinduced electronic transition is critical. Unambiguously describing this evolution in peridinin, and light-harvesting carotenoids in general, has proven elusive experimentally and computationally. To offer a balanced description of bright- and dark-state electronic structure, we here apply ab initio multireference perturbation theory quantum chemistry-the density matrix renormalization group self-consistent-field (DMRG-SCF) and complete-active space self-consistent field (CASSCF) with second-order N-electron valence perturbation theory (NEVPT2)...
May 14, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29750865/surface-modification-with-a-catechol-bearing-polypeptide-and-sensing-applications
#2
Eda Aydindogan, Emine Guler Celik, Dilek Odaci Demirkol, Shuhei Yamada, Takeshi Endo, Suna Timur, Yusuf Yagci
A novel catechol bearing polypeptide (CtP) was synthesized and used as a component of electrochemical biosensor involving both enzymatic activity and affinity-based sensing systems. Glucose oxidase (GOx) and Anti-Immunoglobulin G (Anti-IgG) were selected as model biorecognition elements for the selective analysis of glucose and IgG. Step by step surface modifications were followed using various techniques such as cyclic voltammetry (CV) and electrochemical impedance spectrometry (EIS) as well as X-Ray photoelectron spectroscopy (XPS)...
May 11, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29749664/the-role-of-neuroimaging-in-the-determination-of-brain-death
#3
Derek MacDonald, Brandie Stewart-Perrin, Jai Jai Shiva Shankar
BACKGROUND AND PURPOSE: Brain death determination (BDD) is primarily a clinical diagnosis, where death is defined as the permanent loss of brainstem function. In scenarios where clinical examinations are inaccurate, ancillary imaging tests are required. The choice of ancillary imaging test is variable, but the common denominator for all of them is to establish a lack of cerebral blood flow. The purpose of this study was to compare the diagnostic accuracy and interrater reliability of different ancillary imaging tests used for BDD...
May 11, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29745630/evaluation-of-multifunctional-imaging-parameters-in-gastro-oesophageal-cancer-using-f-18-fdg-pet-ct-with-integrated-perfusion-ct
#4
Bert-Ram Sah, Christian A Leissing, Gaspar Delso, Edwin E Ter Voert, Stefan Krieg, Sebastian Leibl, Paul M Schneider, Cäcilia S Reiner, Martin W Hüllner, Patrick Veit-Haibach
BACKGROUND: Positron emission tomography (PET) / computed tomography (CT) is among the most frequently used imaging modalities for initial staging of gastro-oesophageal (GE) cancer, whereas CT-perfusion (CTP) provides different multiparametric information. This proof of concept study compares CTP- and PET-parameters in patients with GE cancer to evaluate correlations and a possible prognostic value of a combined PET/CTP imaging procedure. METHODS: A total of 31 patients with F-18-FDG-PET/CT and CTP studies were prospectively analysed...
May 10, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29744430/preparation-of-chitin-pla-laminated-composite-for-implantable-application
#5
Romana Nasrin, Shanta Biswas, Taslim Ur Rashid, Sanjida Afrin, Rumana Akhter Jahan, Papia Haque, Mohammed Mizanur Rahman
The present study explores the possibilities of using locally available inexpensive waste prawn shell derived chitin reinforced and bioabsorbable polylactic acid (PLA) laminated composites to develop new materials with excellent mechanical and thermal properties for implantable application such as in bone or dental implant. Chitin at different concentration (1-20% of PLA) reinforced PLA films (CTP) were fabricated by solvent casting process and laminated chitin-PLA composites (LCTP) were prepared by laminating PLA film (obtained by hot press method) with CTP also by hot press method at 160 °C...
December 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29743797/natural-history-of-cirrhosis-of-liver-after-first-decompensation-a-prospective-study-in-india
#6
Apurva S Shah, Deepak N Amarapurkar
Background and aims: As liver cirrhosis is a dynamic condition, it is possible to improve survival in decompensated cirrhosis. Hence, we planned a prospective study to determine the natural history of cirrhosis after first decompensation. Methods: We enrolled all patients of liver cirrhosis who presented with first episode of decompensation defined by the presence of ascites, either overt or detected by Ultrasonography (UD), Gastroesophageal Variceal Bleeding (GEVB), and Hepatic Encephalopathy (HE)...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743794/role-of-indocyanine-green-in-predicting-post-transarterial-chemoembolization-liver-failure-in-hepatocellular-carcinoma
#7
Shalimar, Sushil Jain, Shivanand R Gamanagatti, Saurabh Kedia, Bhaskar Thakur, Baibaswata Nayak, Harpreet Kaur, Deepak Gunjan, Shashi B Paul, Subrat K Acharya
Background/aim: Post-Transarterial Chemoembolization (TACE) Liver Failure (LF) is common in patients with Hepatocellular Carcinoma (HCC). No definitive objective parameters predict its occurrence. We assessed the role of Indocyanine Green (ICG) in prediction of post-TACE LF. Methods: Consecutive HCC patients with Child A/B class, categorized as Barcelona Clinic Liver Cancer (BCLC) staging A/B, were included between August 2012 and July 2014. All underwent ICG dynamics: Plasma Disappearance Rate (PDR) was recorded on the day of TACE...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29739914/computed-tomographic-perfusion-predicts-poor-outcomes-in-a-randomized-trial-of-endovascular-therapy
#8
Robert Wannamaker, Taurian Guinand, Bijoy K Menon, Andrew Demchuk, Mayank Goyal, Donald Frei, Aditya Bharatha, Tudor G Jovin, Jai Shankar, Timo Krings, Blaise Baxter, Christine Holmstedt, Richard Swartz, Dar Dowlatshahi, Richard Chan, Donatella Tampieri, Hana Choe, Paul Burns, Nina Gentile, Jeremy Rempel, Ashfaq Shuaib, Brian Buck, Andrew Bivard, Michael Hill, Kenneth Butcher
BACKGROUND AND PURPOSE: In the ESCAPE trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion with Emphasis on Minimizing CT to Recanalization Times), patients with large vessel occlusions and small infarct cores identified with computed tomography (CT)/CT angiography were randomized to endovascular therapy or standard of care. CT perfusion (CTP) was obtained in some cases but was not used to select patients. We tested the hypothesis that patients with penumbral CTP patterns have higher rates of good clinical outcome...
May 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29733831/fibrosis-severity-as-a-determinant-of-cause-specific-mortality-in-patients-with-advanced-nonalcoholic-fatty-liver-disease
#9
Eduardo Vilar-Gomez, Luis Calzadilla-Bertot, Vincent Wai-Sun Wong, Marlen Castellanos, Rocio Aller-de la Fuente, Mayada Metwally, Mohammed Eslam, Licet Gonzalez-Fabian, María Alvarez-Quiñones Sanz, Antonio Felix Conde-Martin, Bastiaan De Boer, Duncan McLeod, Anthony Wing Hung Chan, Naga Chalasani, Jacob George, Leon A Adams, Manuel Romero-Gomez
BACKGROUND & AIMS: Little is known about the natural course of nonalcoholic fatty liver disease (NAFLD) with advanced fibrosis. We describe long-term outcomes and evaluate the effects of clinical and histologic parameters on disease progression in patients with advanced NAFLD. METHODS: We conducted a multi-national study of 458 patients with biopsy-confirmed NAFLD with bridging fibrosis (F3, n=159) or compensated cirrhosis (222 patients with Child-Turcotte-Pugh [CTP] scores of A5 and 77 patients with scores of A6), evaluated from April 1995 through November 2013 and followed until December 2016, death, or liver transplantation at hepatology centers in Spain, Australia, Hong Kong, and Cuba...
May 4, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29730016/diagnostic-accuracy-of-semi-automatic-quantitative-metrics-as-an-alternative-to-expert-reading-of-ct-myocardial-perfusion-in-the-core320-study
#10
Mohammad R Ostovaneh, Andrea L Vavere, Vishal C Mehra, Klaus F Kofoed, Matthew B Matheson, Armin Arbab-Zadeh, Yasuko Fujisawa, Joanne D Schuijf, Carlos E Rochitte, Arthur J Scholte, Kakuya Kitagawa, Marc Dewey, Christopher Cox, Marcelo F DiCarli, Richard T George, Joao A C Lima
AIMS: To determine the diagnostic accuracy of semi-automatic quantitative metrics compared to expert reading for interpretation of computed tomography perfusion (CTP) imaging. METHODS: The CORE320 multicenter diagnostic accuracy clinical study enrolled patients between 45 and 85 years of age who were clinically referred for invasive coronary angiography (ICA). Computed tomography angiography (CTA), CTP, single photon emission computed tomography (SPECT), and ICA images were interpreted manually in blinded core laboratories by two experienced readers...
April 3, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29728535/how-cct%C3%AE-puts-a-leash-on-phospholipid-synthesis
#11
Neale D Ridgway
The proportion of phosphatidylcholine (PC) in the membrane is controlled by CTP:phosphocholine cytidylyltransferase α (CCTα), which is known to be regulated by a dual auto-inhibitory and membrane-binding domain. However, the detailed mechanism by which this domain regulates CCTα activity is not clear. Ramezanpour et al. use a combined computational and biochemical approach to define new details of this mechanism, providing an elegant illustration of how the lipid-sensing domain of a phospholipid biosynthetic enzyme controls membrane homeostasis...
May 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29727439/accuracy-of-computed-tomographic-perfusion-in-diagnosis-of-brain-death-a-prospective-cohort-study
#12
Marcin Sawicki, Joanna Sołek-Pastuszka, Katarzyna Chamier-Ciemińska, Anna Walecka, Romuald Bohatyrewicz
BACKGROUND This study was designed to determine diagnostic accuracy of computed tomographic perfusion (CTP) compared to computed tomographic angiography (CTA) for the diagnosis of brain death (BD). MATERIAL AND METHODS Whole-brain CTP was performed in patients diagnosed with BD and in patients with devastating brain injury with preserved brainstem reflexes. CTA was derived from CTP datasets. Cerebral blood flow (CBF) and volume (CBV) were calculated in all brain regions. CTP findings were interpreted as confirming diagnosis of BD (positive) when CBF and CBV in all ROIs were below 10 mL/100 g/min and 1...
May 4, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29724610/ischemic-volume-and-neurological-deficit-correlation-of-computed-tomography-perfusion-with-the-national-institutes-of-health-stroke-scale-score-in-acute-ischemic-stroke
#13
Giovanni Furlanis, Miloš Ajčević, Lara Stragapede, Carlo Lugnan, Mariana Ridolfi, Paola Caruso, Marcello Naccarato, Maja Ukmar, Paolo Manganotti
BACKGROUND: The National Institutes of Health Stroke Scale (NIHSS) is the most adopted stroke patients' evaluation tool in emergency settings to assess the severity of stroke and to determine the patients' eligibility for specific treatments. Computed tomography perfusion (CTP) is crucial to identify salvageable tissue that can benefit from the reperfusion treatment. The aim of this study is to identify the relation between the NIHSS scores and the hypoperfused volumes evaluated by CTP in patients with hyperacute ischemic stroke...
April 30, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29723133/antipyrimidine-effects-of-five-different-pyrimidine-de-novo-synthesis-inhibitors-in-three-head-and-neck-cancer-cell-lines
#14
Godefridus J Peters
The pyrimidine de novo nucleotide synthesis consists of 6 sequential steps. Various inhibitors against these enzymes have been developed and evaluated in the clinic for their potential anticancer activity: acivicin inhibits carbamoyl-phosphate-synthase-II, N-(phosphonacetyl)-L- aspartate (PALA) inhibits aspartate-transcarbamylase, Brequinar sodium and dichloroallyl-lawsone (DCL) inhibit dihydroorotate-dehydrogenase, and pyrazofurin (PF) inhibits orotate-phosphoribosyltransferase. We compared their growth inhibition against 3 cell lines from head-and-neck-cancer (HEP-2, UMSCC-14B and UMSCC-14C) and related the sensitivity to their effects on nucleotide pools...
May 3, 2018: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/29717475/antibacterial-anti-inflammatory-and-bone-regenerative-dual-drug-loaded-calcium-phosphate-nanocarriers-in-vitro-and-in-vivo-studies
#15
K Madhumathi, Y Rubaiya, Mukesh Doble, R Venkateswari, T S Sampath Kumar
A dual local drug delivery system (DDS) composed of calcium phosphate bioceramic nanocarriers aimed at treating the antibacterial, anti-inflammatory, and bone-regenerative aspects of periodontitis has been developed. Calcium-deficient hydroxyapatite (CDHA, Ca/P = 1.61) and tricalcium phosphate (β-TCP) were prepared by microwave-accelerated wet chemical synthesis method. The phase purity of the nanocarriers was confirmed by x-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR), while the transmission electron microscopy (TEM) confirmed their nanosized morphology...
May 1, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29713770/comprehensive-morphologic-and-functional-imaging-of-heart-transplant-patients-first-experience-with-dynamic-perfusion-ct
#16
S Oebel, S Hamada, K Higashigaito, J von Spiczak, E Klotz, F Enseleit, R Hinzpeter, F Ruschitzka, R Manka, H Alkadhi
OBJECTIVES: We aimed to assess the diagnostic performance of a combined protocol with coronary computed tomography angiography (CCTA) and stress CT perfusion imaging (CTP) in heart transplant patients for comprehensive morphological and functional imaging. METHODS: In this prospective study, 13 patients undergoing routine follow-up 8±6 years after heart transplantation underwent CCTA and dynamic adenosine stress CTP using a third-generation dual-source CT scanner, cardiac magnetic resonance (MR) adenosine stress perfusion imaging at 1...
April 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29688583/safe-use-of-proton-pump-inhibitors-in-patients-with-cirrhosis
#17
Rianne A Weersink, Margriet Bouma, David M Burger, Joost P H Drenth, S Froukje Harkes-Idzinga, Nicole G M Hunfeld, Herold J Metselaar, Margje H Monster-Simons, Sandra A W van Putten, Katja Taxis, Sander D Borgsteede
AIMS: Proton pump inhibitors (PPIs) belong to the most frequently used drugs, also in patients with cirrhosis. PPIs are extensively metabolized by the liver, but practice guidance on prescribing in cirrhosis is lacking. We aim to develop practical guidance on the safe use of PPIs in cirrhosis. METHODS: A systematic literature search identified studies about the safety (i.e. adverse events) and pharmacokinetics of PPIs in cirrhotic patients. This evidence and data from the product information was reviewed by an expert panel who classified drugs as safe; no additional risks known; additional risks known; unsafe; or unknown...
April 24, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29685364/myocardial-repolarization-is-affected-in-patients-with-ascending-aortic-aneurysm
#18
Mustafa Topuz, Ömer Genç, Armagan Acele, Mevlüt Koc
OBJECTIVE: Ascending aortic aneurysm (AAA) is one of the major causes of ventricular diastolic dysfunction. Diastolic dysfunction can induce ventricular repolarization dispersion. Nevertheless, myocardial repolarization dispersion is not yet to be fully evaluated in patients with AAA. We aimed to evaluate ventricular repolarization using QT and Tp-Te interval and corrected (c) Tp-Te/QT ratio in patients with AAA. METHODS: One hundred-four patients with AAA without coronary artery disease (CAD) served as the aneurysm group and 82 patients having a normal aortic diameter as the control group...
February 13, 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29672633/design-synthesis-dft-docking-studies-and-adme-prediction-of-some-new-coumarinyl-linked-pyrazolylthiazoles-potential-standalone-or-adjuvant-antimicrobial-agents
#19
Sunil Kumar, Vikram Saini, Indresh K Maurya, Jayant Sindhu, Mukesh Kumari, Ramesh Kataria, Vinod Kumar
The control of antimicrobial resistance (AMR) seems to have come to a dead end. The major consequences of the use and abuse of antibacterial drugs are the development of resistant strains due to genetic mutability of both pathogenic and nonpathogenic microorganisms. We, herein, report the synthesis, characterization and biological activities of coumarin-thiazole-pyrazole (CTP) molecular hybrids with an effort to explore and overcome the increasing antimicrobial resistance. The compounds were characterized by analyzing their IR, Mass, 1H and13C NMR spectral data and elemental analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29668120/cytomegalovirus-infection-in-living-donor-liver-transplant-recipients-significantly-impacts-the-early-post-transplant-outcome-a-single-center-experience
#20
Sanjay Kumar Yadav, Sanjiv Saigal, Narendra Singh Choudhary, Sujeet Saha, Jayant Kumar Sah, Neeraj Saraf, Naveen Kumar, Sanjay Goja, Amit Rastogi, Prashant Bhangui, A S Soin
BACKGROUND: Cytomegalovirus (CMV) is the most common viral infection in liver transplant recipients that influences the outcomes of liver transplantation. However, its impact on early outcomes following living donor liver transplantation (LDLT) is not fully defined in the Indian subcontinent. This study was done to assess the impact of CMV infection on early post-transplant outcomes in LDLT recipients. METHODS: Out of 272 LDLTs performed from January 2012 to April 2013, 151 recipients underwent CMV viral load analysis in plasma within 90 days post LDLT based on clinical suspicion...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
keyword
keyword
23508
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"