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Stroke imaging

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https://www.readbyqxmd.com/read/29907385/long-term-changes-in-cerebrovascular-reactivity-following-ec-ic-bypass-for-intracranial-steno-occlusive-disease
#1
Casey Rosen, Larissa McKetton, Jeremy Russell, Kevin Sam, Julien Poublanc, Adrian Crawley, Jay S Han, Olivia Sobczyk, James Duffin, Danny M Mandell, Michael Tymianski, Joseph A Fisher, David J Mikulis, Lashmi Venkatraghavan
The purpose of this retrospective observational study is to investigate the long-term changes in cerebrovascular reactivity (CVR) as a measure of cerebral hemodynamics in patients with intracranial steno-occlusive disease (IC-SOD) after they have undergone an Extracranial-intracranial (EC-IC) bypass. Twenty-six patients suffering from IC-SOD were selected from our CVR database. Nineteen patients underwent unilateral and 7 underwent bilateral revascularization. CVR measurements were done using BOLD-MRI and precisely controlled CO2 and expressed as ΔBOLD (%)/Δ PET CO2 (mmHg)...
June 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29907089/temporarily-increased-stroke-rate-after-takotsubo-syndrome-need-for-an-anticoagulation
#2
Nadine Abanador-Kamper, Lars Kamper, Judith Wolfertz, Marc Vorpahl, Patrick Haage, Melchior Seyfarth
BACKGROUND: Previous studies have reported slightly higher stroke rates in Takotsubo Syndrome compared to acute myocardial infarction. Our goal was to evaluate the temporal course of stroke rates and left ventricular recovery in patients with Takotsubo Syndrome. METHODS: We retrospectively examined the clinical and imaging data of 72 patients with Takotsubo Syndrome. The data collected came from January 2005 to March 2017. Left ventricular performance was evaluated by cardiovascular magnetic resonance imaging (MRI) in all patients during the acute phase of Takotsubo Syndrome and in a follow-up scan 2 months later...
June 15, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29906552/interleukin-33-protects-ischemic-brain-injury-by-regulating-specific-microglial-activities
#3
Qianping Luo, Yong Fan, Lili Lin, Jingjing Wei, Zuanfang Li, Yongkun Li, Susumu Nakae, Wei Lin, Qi Chen
Interleukin-33 (IL-33), a novel member of the IL-1 family, expressed in many tissue and cell types, and is involved in inflammation and immune functions. Previous studies suggest that IL-33 may play a role in ischemic stroke. We tried to investigate the role of IL-33 in cerebral ischemia-reperfusion-induced injury and its underlying mechanism. Our data indicated that IL-33 deficiency exacerbated the neurological dysfunction caused by cerebral ischemia-reperfusion injury in mice and led to the formation of larger cerebral infarct volume as shown by 2,3,5-triphenyltetrazolium chloride (TTC) staining and magnetic resonance imaging...
June 12, 2018: Neuroscience
https://www.readbyqxmd.com/read/29904963/experience-of-a-single-center-in-the-conservative-approach-of-20-consecutive-cases-of-asymptomatic-extracranial-carotid-artery-aneurysms
#4
V E C Pourier, J C Welleweerd, L J Kappelle, G J E Rinkel, Y M Ruigrok, H B van der Worp, T H Lo, M L Bots, F L Moll, Gert J de Borst
BACKGROUND: The clinical course and optimal treatment strategy for asymptomatic aneurysms of the extracranial carotid artery (ECAA) are unknown. We report our single-center experience with conservative management of patients with an asymptomatic ECAA. METHODS: A search in our hospital records from 1998 to 2013 revealed 20 patients (mean age 52 years, SD 12.5) with 23 ECAA, defined as a 150% or more fusiform dilation or any saccular dilatation compared to the healthy internal carotid artery...
June 14, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29904454/a-rare-case-of-native-mitral-valve-bacillus-cereus-endocarditis-culminating-into-a-cerebrovascular-infarction
#5
Bibai Ren, Glenmore Lasam
We report a case of a 56-year-old man who presented initially with a sudden onset of right-sided facial droop and weakness, aphasia, and confusion with no associated fever, chills, syncope, fatigue, weight loss, night sweats, nausea, vomiting, diarrhea, odontalgia, palpitations, cough, or dyspnea. Code stroke was called and the patient received tissue plasminogen activator (tPA) with subsequent resolution of his symptoms. Cranial magnetic resonance imaging showed left frontal punctate cortical restricted diffusion consistent with subacute to acute infarction...
June 2018: Cardiology Research
https://www.readbyqxmd.com/read/29903927/time-course-of-cerebral-perfusion-changes-in-children-with-migraine-with-aura-mimicking-stroke
#6
K M Cobb-Pitstick, N Munjal, R Safier, D D Cummings, G Zuccoli
Hemiplegic migraine is a common cause of acute brain attack in pediatrics. MR imaging sequences useful in differentiating hemiplegic migraine from other entities include arterial spin-labeling, SWI, MRA, and DWI. There has been limited exploration on the simultaneous use of these sequences in pediatrics. We present 12 pediatric patients with acute hemiplegic migraine or migraine with aura who underwent MR imaging within 12 hours of symptom onset. Quantitative and qualitative analyses were performed on arterial spin-labeling; and qualitative analysis, on SWI and MRA sequences...
June 14, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29903733/t-cells-prevent-hemorrhagic-transformation-in-ischemic-stroke-by-p-selectin-binding
#7
Angélica Salas-Perdomo, Francesc Miró-Mur, Xabier Urra, Carles Justicia, Mattia Gallizioli, Yashu Zhao, Vanessa H Brait, Carlos Laredo, Raúl Tudela, Andrés Hidalgo, Ángel Chamorro, Anna M Planas
OBJECTIVE: Hemorrhagic transformation is a serious complication of ischemic stroke after recanalization therapies. This study aims to identify mechanisms underlying hemorrhagic transformation after cerebral ischemia/reperfusion. APPROACH AND RESULTS: We used wild-type mice and Selplg-/- and Fut7-/- mice defective in P-selectin binding and lymphopenic Rag2-/- mice. We induced 30-minute or 45-minute ischemia by intraluminal occlusion of the middle cerebral artery and assessed hemorrhagic transformation at 48 hours with a hemorrhage grading score, histological means, brain hemoglobin content, or magnetic resonance imaging...
June 14, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29903683/correlating-oxygen-delivery-during-cardiopulmonary-bypass-with-the-neurologic-injury-biomarker-ubiquitin-c-terminal-hydrolase-l1-uch-l1
#8
J Trent Magruder, Charles D Fraser, Joshua C Grimm, Todd C Crawford, Claude A Beaty, Alejandro Suarez-Pierre, Ronald L Hayes, Michael V Johnston, William A Baumgartner
OBJECTIVE: The authors sought to assess the relationship between low oxygen delivery (DO2 ) during cardiopulmonary bypass (CPB) and a neuron-specific biomarker of neurologic injury, ubiquitin C-terminal hydrolase L1 (UCH-L1). DESIGN: Retrospective analysis of patient charts and prospectively collected blood samples. SETTING: University-affiliated tertiary care hospital. PARTICIPANTS: Adult patients undergoing cardiac surgery on CPB...
June 11, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29900409/estimating-the-number-of-uk-stroke-patients-eligible-for-endovascular-thrombectomy
#9
Peter McMeekin, Philip White, Martin A James, Christopher I Price, Darren Flynn, Gary A Ford
Introduction: Endovascular thrombectomy is a highly effective treatment for acute ischemic stroke due to large arterial occlusion. Routine provision will require major changes in service configuration and workforce. An important first step is to quantify the population of stroke patients that could benefit. We estimated the annual UK population suitable for endovascular thrombectomy using standard or advanced imaging for patient selection. Patients and methods: Evidence from randomised control trials and national registries was combined to estimate UK stroke incidence and define a decision-tree describing the endovascular thrombectomy eligible population...
December 2017: European stroke journal
https://www.readbyqxmd.com/read/29899777/basal-ganglia-infarct-following-trivial-trauma-in-a-child-case-report-and-review-of-literature
#10
Satyashiva Munjal, Amit Srivastava, Kavita Kapoor, Veer Singh Mehta
A 2-year-old boy was presented to us with right-side hemiparesis after trivial fall. Diffusion-weighted magnetic resonance imaging showed an infarct in left basal ganglia and thalamic region. Secondary causes of stroke were ruled out. The child was managed conservatively. Basal ganglia infarct secondary to minor trauma is a rare event. Possible mechanisms leading to such an event and its management are discussed.
January 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29898838/randomized-placebo-controlled-trial-evaluating-the-safety-and-efficacy-of-single-low-dose-intracoronary-insulin-like-growth-factor-following-percutaneous-coronary-intervention-in-acute-myocardial-infarction-resus-ami
#11
Noel M Caplice, Mary C DeVoe, Janet Choi, Darren Dahly, Theodore Murphy, Ernest Spitzer, Robert Van Geuns, Michael M Maher, David Tuite, David M Kerins, Mohammed T Ali, Imtiaz Kalyar, Eoin F Fahy, Wisam Khider, Peter Kelly, Peter P Kearney, Ronan J Curtin, Conor O'Shea, Carl J Vaughan, Joseph A Eustace, Eugene P McFadden
BACKGROUND: Residual and significant postinfarction left ventricular (LV) dysfunction, despite technically successful percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI), remains an important clinical issue. In preclinical models, low-dose insulin-like growth factor 1 (IGF1) has potent cytoprotective and positive cardiac remodeling effects. We studied the safety and efficacy of immediate post-PCI low-dose intracoronary IGF1 infusion in STEMI patients...
June 2018: American Heart Journal
https://www.readbyqxmd.com/read/29897627/real-world-geographic-variations-in-the-use-of-cardiac-implantable-electronic-devices-the-panorama-2-observational-cohort-study
#12
Dirk Bastian, Iftikhar O Ebrahim, Ju-Yi Chen, Mien-Cheng Chen, Dejia Huang, Jin-Long Huang, Vadim A Kuznetsov, Bärbel Maus, Ajay M Naik, Koen J P Verhees, Ahmed R Al Fagih
BACKGROUND: Currently, several geographies around the world remain underrepresented in medical device trials. The PANORAMA 2 study was designed to assess contemporary region-specific differences in clinical practice patterns of patients with cardiac implantable electronic devices (CIEDs). METHODS: In this prospective, multicenter, observational, multi-national study, baseline and implant data of 4,706 patients receiving Medtronic CIEDs (either de novo device implants, replacements, or upgrades) were analyzed, consisting of: 54% implantable pulse generators (IPGs), 20...
June 13, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29897429/anaortic-coronary-surgery-using-the-%C3%AE-circuit-is-associated-with-a-low-incidence-of-perioperative-neurological-complications
#13
Sotirios Prapas, Antonio Maria Calafiore, Konstantinos P Katsavrias, Ioannis A Panagiotopoulos, Ioannis N Linardakis, Fabrizio Tancredi, Massimiliano Foschi, Michele Di Mauro
OBJECTIVES: Our goal was to compare the observed and the expected rates of postoperative cerebrovascular accidents (CVA) in a large cohort of consecutive patients undergoing off-pump coronary artery bypass grafting (CABG) using the ∏-circuit as a no-touch technique. METHODS: From January 2001 to May 2016, 3081 patients were consecutively submitted to an off-pump CABG operation using the ∏-circuit. A CVA was defined as a neurological deficit, lasting less (transient ischaemic attack) or more (stroke) than 24 h, diagnosed by a neurologist and confirmed by a computed tomography or magnetic resonance imaging scan of the brain...
June 11, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29896664/neurological-disorders-associated-with-human-alphaherpesviruses
#14
Jun-Ichi Kawada
Herpes simplex virus (HSV) encephalitis is the most common cause of sporadic fatal encephalitis worldwide, and central nervous system (CNS) involvement is observed in approximately one-third of neonatal HSV infections . In recent years, single-gene inborn errors of innate immunity have been shown to be associated with susceptibility to HSV encephalitis . Temporal lobe abnormalities revealed by magnetic resonance imaging-the most sensitive imaging method for HSV encephalitis-are considered strong evidence for the disease...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29896429/invasion-of-peripheral-immune-cells-into-brain-parenchyma-after-cardiac-arrest-and-resuscitation
#15
Can Zhang, Nicole R Brandon, Kerryann Koper, Pei Tang, Yan Xu, Huanyu Dou
Although a direct link has long been suspected between systemic immune responses and neuronal injuries after stroke, it is unclear which immune cells play an important role. A question remains as to whether the blood brain barrier (BBB) is transiently disrupted after circulatory arrest to allow peripheral immune cells to enter brain parenchyma. Here, we developed a clinically relevant cardiac arrest and resuscitation model in mice to investigate the BBB integrity using noninvasive magnetic resonance imaging...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896407/-campylobacter-fetus-prosthetic-valve-endocarditis-presenting-as-a-stroke
#16
Christina Petridou, Lenka Strakova, Ruan Simpson
Introduction: Campylobacter is a common pathogen of the gastrointestinal tract, but invasive disease is rare. Campylobacter fetus can play a role in osteomyelitis, meningitis and joint infection and has a prediliction for the vascular endothelium, causing mycotic aneurysms, thrombophlebitis and endocarditis. Here we present a case of prosthetic valve endocarditis caused by C. fetus and a review of the literature. Case presentation: An 85-year-old woman with a tissue aortic valve replacement and atrial fibrillation was admitted to hospital with tonic-clonic seizures, right-sided hemiparesis, facial droop and hemianopia...
May 2018: JMM Case Reports
https://www.readbyqxmd.com/read/29895577/marantic-endocarditis-incidental-infarcts-leading-to-diagnosis-of-pancreatic-cancer
#17
Ella Starobinska, Eric A Robinson, Eric Brucks, Serena Scott
Non-bacterial thrombotic endocarditis (NBTE) is a well-described phenomenon associated with malignancies due to hypercoaguable state. In the setting of pancreatic cancer, NBTE is more commonly diagnosed postmortem. We describe a case of a man who was diagnosed with pancreatic carcinoma after incidental finding of NBTE. Imaging incidentally revealed multiple strokes, bilateral renal and splenic infarcts, while subsequent workup for cardioembolic source demonstrated a 1.1×0.7 cm mitral valve vegetation. As multiple blood cultures were sterile and patient lacked clinical signs of infection, an underlying malignancy was suspected...
June 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29895538/quantifying-infarct-growth-and-secondary-injury-volumes-comparing-multimodal-image-registration-measures
#18
George W J Harston, Davide Carone, Fintan Sheerin, Mark Jenkinson, James Kennedy
BACKGROUND AND PURPOSE: Lesion expansion in the week after acute stroke involves both infarct growth (IG) and anatomic distortion (AD) because of edema and hemorrhage. Enabling separate quantification would allow clinical trials targeting these distinct pathological processes. We developed an objective and automated approach to quantify these processes at 24 hours and 1 week. METHODS: Patients with acute ischemic stroke were scanned at presentation, 24 hours, and 1 week in a magnetic resonance imaging (MRI) cohort study...
June 12, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29895322/moyamoya-disease-in-a-moroccan-baby-a-case-report
#19
Abdelhafid Houba, Nisrine Laaribi, Mohammed Meziane, Abdelhamid Jaafari, Khalil Abouelalaa, Mustapha Bensghir
BACKGROUND: A stroke in a baby is uncommon, recent studies suggested that their incidence is rising. Moyamoya disease is one of the leading causes of stroke in babies. This condition is mostly described in Japan. In Morocco, moyamoya disease has rarely been reported and a few cases were published. We report a rare Moroccan case of a 23-month-old baby boy who presented with left-sided hemiparesis and was diagnosed as having moyamoya disease. CASE PRESENTATION: A 23-month-old full-term Moroccan baby boy born to a non-consanguineous couple was referred to our hospital with the complaint of sudden onset left-sided hemiparesis...
June 13, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29895299/association-between-abdominal-adiposity-and-subclinical-measures-of-left-ventricular-remodeling-in-diabetics-prediabetics-and-normal-controls-without-history-of-cardiovascular-disease-as-measured-by-magnetic-resonance-imaging-results-from-the-kora-ff4-study
#20
Christopher L Schlett, Roberto Lorbeer, Carolyn Arndt, Sigrid Auweter, Jürgen Machann, Holger Hetterich, Birgit Linkohr, Wolfgang Rathmann, Annette Peters, Fabian Bamberg
OBJECTIVES: Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potential interaction with hyperglycemic metabolic states. METHODS: Subjects from the general population and without history of cardiovascular disease were drawn from the Cooperative Health Research in the Region of Augsburg FF4 cohort and underwent 3 T cardiac and body MRI...
June 12, 2018: Cardiovascular Diabetology
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