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https://www.readbyqxmd.com/read/28443626/nanodiamond-enhanced-mri-via-in-situ-hyperpolarization
#1
David E J Waddington, Mathieu Sarracanie, Huiliang Zhang, Najat Salameh, David R Glenn, Ewa Rej, Torsten Gaebel, Thomas Boele, Ronald L Walsworth, David J Reilly, Matthew S Rosen
Nanodiamonds are of interest as nontoxic substrates for targeted drug delivery and as highly biostable fluorescent markers for cellular tracking. Beyond optical techniques, however, options for noninvasive imaging of nanodiamonds in vivo are severely limited. Here, we demonstrate that the Overhauser effect, a proton-electron polarization transfer technique, can enable high-contrast magnetic resonance imaging (MRI) of nanodiamonds in water at room temperature and ultra-low magnetic field. The technique transfers spin polarization from paramagnetic impurities at nanodiamond surfaces to (1)H spins in the surrounding water solution, creating MRI contrast on-demand...
April 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28443558/towards-evidence-based-resuscitation-of-the-newborn-infant
#2
REVIEW
Brett J Manley, Louise S Owen, Stuart B Hooper, Susan E Jacobs, Jeanie L Y Cheong, Lex W Doyle, Peter G Davis
Effective resuscitation of the newborn infant has the potential to save many lives around the world and reduce disabilities in children who survive peripartum asphyxia. In this Series paper, we highlight some of the important advances in the understanding of how best to resuscitate newborn infants, which includes monitoring techniques to guide resuscitative efforts, increasing awareness of the adverse effects of hyperoxia, delayed umbilical cord clamping, the avoidance of routine endotracheal intubation for extremely preterm infants, and therapeutic hypothermia for hypoxic-ischaemic encephalopathy...
April 22, 2017: Lancet
https://www.readbyqxmd.com/read/28441236/the-new-mirus-system-for-short-term-sedation-in-postsurgical-icu-patients
#3
Stefano Romagnoli, Cosimo Chelazzi, Gianluca Villa, Giovanni Zagli, Francesco Benvenuti, Paola Mancinelli, Giulio Arcangeli, Stefano Dugheri, Alessandro Bonari, Lorenzo Tofani, Andrea Belardinelli, A Raffaele De Gaudio
OBJECTIVES: To evaluate the feasibility and safety of the MIRUS system (Pall International, Sarl, Fribourg, Switzerland) for sedation with sevoflurane for postsurgical ICU patients and to evaluate atmospheric pollution during sedation. DESIGN: Prospective interventional study. SETTING: Surgical ICU. February 2016 to December 2016. PATIENTS: Postsurgical patients requiring ICU admission, mechanical ventilation, and sedation...
April 22, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28438825/beyond-use-dating-of-lidocaine-alone-and-in-two-magic-mouthwash-preparations
#4
Loren Madden Kirk, Stacy D Brown, Yao Luu, Amanda Ogle, Jessica Huffman, Paul O Lewis
PURPOSE: Beyond-use dating (BUD) of lidocaine alone and in two "magic mouthwash" preparations stored in amber oral syringes at room temperature was determined. METHODS: Two formulations of mouthwash containing oral topical lidocaine 2% (viscous), diphenhydramine 2.5 mg/mL, and aluminum hydroxide-magnesium hydroxide-simethicone were prepared in 1:1:1 and 1:2.5:2.5 ratios, divided into 3-mL samples, and stored in unit-dose oral amber syringes. Unit-dose single-product lidocaine samples were also prepared to serve as controls and stored in oral amber syringes...
May 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28435248/redox-sensitive-pluronic-f127-tocopherol-micelles-synthesis-characterization-and-cytotoxicity-evaluation
#5
Yuling Liu, Sai Fu, Longfei Lin, Yuhong Cao, Xi Xie, Hua Yu, Meiwan Chen, Hui Li
Pluronic F127 (F127), an amphiphilic triblock copolymer, has been shown to have significant potential for drug delivery, as it is able to incorporate hydrophobic drugs and self-assemble into nanosize micelles. However, it suffers from dissociation upon dilution owing to the relatively high critical micelle concentration and lack of stimuli-responsive behavior. Here, we synthesized the α-tocopherol (TOC) modified F127 polymer (F127-SS-TOC) via a redox-sensitive disulfide bond between F127 and TOC, which formed stable micelles at relatively low critical micelle concentration and was sensitive to the intracellular redox environment...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28432967/friendliness-functionality-and-freedom-design-characteristics-that-support-midwifery-practice-in-the-hospital-setting
#6
Athena Hammond, Caroline S E Homer, Maralyn Foureur
OBJECTIVE: to identify and describe the design characteristics of hospital birth rooms that support midwives and their practice. DESIGN: this study used a qualitative exploratory descriptive methodology underpinned by the theoretical approach of critical realism. Data was collected through 21 in-depth, face-to-face photo-elicitation interviews and a thematic analysis guided by study objectives and the aims of exploratory research was undertaken. SETTING: the study was set at a recently renovated tertiary hospital in a large Australian city...
April 4, 2017: Midwifery
https://www.readbyqxmd.com/read/28432730/assessment-of-voluntary-deep-inspiration-breath-hold-with-cine-imaging-for-breast-radiotherapy
#7
Reuben Patrick Estoesta, Lani Attwood, Diana Naehrig, Elizabeth Claridge-Mackonis, David Odgers, Darren Martin, Melissa Pham, Joanne Toohey, Susan Carroll
Deep Inspiration Breath-Hold (DIBH) techniques for breast cancer radiation therapy (RT) have reduced cardiac dose compared to Free Breathing (FB). Recently, a voluntary deep inspiration breath-hold (vDIBH) technique was established using in-room lasers and skin tattoos to monitor breath-hold. An in-house quality assessment of positional reproducibility during RT delivery with vDIBH in patients with left-sided breast cancer was evaluated. The electronic portal imaging device (EPID) was used in cinematographic (CINE) mode to capture a sequence of images during beam delivery...
April 22, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28429391/technical-note-direct-measurement-of-continuous-tmr-data-with-a-1d-tank-and-automated-couch-movements
#8
Nels C Knutson, Matthew C Schmidt, Matthew D Belley, Ngoc Nguyen, H Harold Li, Erno Sajo, Michael Price
PURPOSE: Real-time dynamic control of the linear accelerator, couch, and imaging parameters during radiation delivery was investigated as a novel technique for acquiring tissue maximum ratio (TMR) data. METHODS: TrueBeam Developer Mode (Varian Medical Systems, Palo Alto, CA) was used to control the linear accelerator using the Extensible Markup Language (XML). A single XML file was used to dynamically manipulate the machine, couch, and imaging parameters during radiation delivery...
April 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28421900/the-magnitude-and-factors-related-to-facility-based-maternal-mortality-in-mozambique
#9
Leonardo Chavane, Martinho Dgedge, Olivier Degomme, Osvaldo Loquiha, Marc Aerts, Marleen Temmerman
Facility-based maternal mortality remains an important public health problem in Mozambique. A number of factors associated with health system functioning can be described behind the occurrence of these deaths. This paper aimed to evaluate the magnitude of the health facility-based maternal mortality, its geographical distribution and to assess the health facility factors implicated in the occurrence of these deaths. A secondary analysis was done on data from the survey on maternal health needs performed by the Ministry of Health of Mozambique in 2008...
May 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28421171/tactile-stimulation-to-stimulate-spontaneous-breathing-during-stabilization-of-preterm-infants-at-birth-a-retrospective-analysis
#10
Janneke Dekker, Tessa Martherus, Sophie J E Cramer, Henriette A van Zanten, Stuart B Hooper, Arjan B Te Pas
BACKGROUND AND AIMS: Tactile maneuvers to stimulate breathing in preterm infants are recommended during the initial assessment at birth, but it is not known how often and how this is applied. We evaluated the occurrence and patterns of tactile stimulation during stabilization of preterm infants at birth. METHODS: Recordings of physiological parameters and videos of infants <32 weeks gestational age were retrospectively analyzed. Details of tactile stimulation during the first 7 min after birth (timing, duration, type, and indication) were noted...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28419627/instantaneous-conversion-of-11c-co2-to-11c-co-via-fluoride-activated-disilane-species
#11
Carlotta Taddei, Salvatore Bongarzone, Antony Gee
The development of a fast and novel methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) mediated by fluoride-activated disilane species is described. This methodology allows up to 74% conversion of [11C]CO2 to [11C]CO using commercially available reagents, readily available labware and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl-11C]N-benzylbenzamide was successfully synthesized from produced [11C]CO in up to 74% radiochemical yield (RCY) and > 99% radiochemical purity (RCP) in ≤ 10 min from end of [11C]CO2 delivery...
April 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28418683/physical-characterization-of-tobramycin-inhalation-powder-ii-state-diagram-of-an-amorphous-engineered-particle-formulation
#12
Dan Miller, Trixie Tan, John Nakamura, Richard Malcolmson, Tom Tarara, Jeff Weers
Tobramycin Inhalation Powder (TIP) is a spray-dried engineered particle formulation used in TOBI® Podhaler®, a drug/device combination for treatment of cystic fibrosis. A TIP particle consists of two phases: amorphous, glassy tobramycin sulfate and a gel-phase phospholipid (DSPC). The objective of this work was to characterize both the amorphous and gel phases following exposure of TIP to a broad range of relative humidity and temperature. Because, in principle, changes in either particle morphology or the solid-state form of the drug could affect drug delivery or biopharmaceutical properties, understanding physical stability was critical to development and registration of this product...
April 18, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28417613/combination-therapy-for-complex-peripheral-artery-disease-the-evidence-for-combining-mechanical-revascularisation-with-anti-restenotic-drug-delivery-systems
#13
Ramon L Varcoe
The management of complex, lower-extremity peripheral artery disease remains a difficult challenge, with ample room for improvement in the results seen with current generation devices. Therapies which use a combination of multiple devices for their mechanical and anti-restenotic properties may be advantageous, and offer an opportunity to improve the durability of revascularization through optimizing and individualizing care. Combination therapy typically utilizes drug delivery devices in addition to stents and atherectomy to achieve improved results...
April 14, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28417459/does-obesity-complicate-regional-anesthesia-and-result-in-longer-decision-to-delivery-time-for-emergency-cesarean-section
#14
A J Väänänen, J P Kainu, H Eriksson, M Lång, A Tekay, J Sarvela
BACKGROUND: Maternal obesity can cause problems with anesthesia and surgery which may be reflected in emergency cesarean sections (CS) as an increased decision-to-delivery interval (DDI). AIM: To study the association of elevated maternal BMI with DDI and the failure of regional anesthesia. METHODS: Eight hundred and forty-two consecutive emergency CSs during a period of 1 year in a tertiary hospital were studied retrospectively. DDIs were analyzed in Crash and < 30-min urgency categories (n = 528), while the time required to establish regional anesthesia and its success were analyzed for all emergency CS cases...
April 17, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28411183/membrane-permeation-of-arginine-rich-cell-penetrating-peptides-independent-of-transmembrane-potential-as-a-function-of-lipid-composition-and-membrane-fluidity
#15
Rike Wallbrecher, Tobias Ackels, R Alis Olea, Marco J Klein, Lucie Caillon, Jürgen Schiller, Petra H Bovée-Geurts, Toin H van Kuppevelt, Anne S Ulrich, Marc Spehr, Merel J W Adjobo-Hermans, Roland Brock
Cell-penetrating peptides (CPPs) are prominent delivery vehicles to confer cellular entry of (bio-) macromolecules. Internalization efficiency and uptake mechanism depend, next to the type of CPP and cargo, also on cell type. Direct penetration of the plasma membrane is the preferred route of entry as this circumvents endolysosomal sequestration. However, the molecular parameters underlying this import mechanism are still poorly defined. Here, we make use of the frequently used HeLa and HEK cell lines to address the role of lipid composition and membrane potential...
April 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28411056/development-and-evaluation-of-resveratrol-vitamin-e-and-epigallocatechin-gallate-loaded-lipid-nanoparticles-for-skin-care-applications
#16
Jin Chen, Ning Wei, Maria Lopez-Garcia, Dianna Ambrose, Jason Lee, Colin Annelin, Teresa Peterson
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been studied as potential carriers for both dermal and transdermal drug delivery. SLN contain lipid droplets that are fully crystallized and have a highly-ordered crystalline structure. NLC are modified SLN in which the lipid phase contains both solid and liquid lipids at room temperature. SLN and NLC are thought to combine the advantages of polymeric particles, liposomes and emulsions. Therefore they provide high encapsulation percentages, better protection for incorporated actives and allow for control of desired release profile...
April 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28410262/life-saving-esophageal-intubation-in-neonate-with-undiagnosed-tracheal-agenesis-a-case-report
#17
Christopher Sattler, Franklin Chiao, David Stein, Denise Murphy
A 3-day-old, 2.2-kg former 34-week premature infant with imperforate anus required loop ileostomy surgery. At delivery, the child had respiratory distress. Endotracheal intubation was "confirmed" by detection of exhaled carbon dioxide with a Pedi-Cap (Covidien, Dublin, Ireland) and subsequent chest x-ray. On arrival to the operating room, the pulse oximeter reading was 100% despite a large leak around the endotracheal tube and high-airway pressures. Packing the throat reduced the leak and increased the tidal volume...
April 13, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28409760/delivery-room-continuous-positive-airway-pressure-and-early-pneumothorax-in-term-newborn-infants
#18
Laura Clevenger, John R Britton
OBJECTIVE: To assess the association between delivery room (DR) continuous positive airway pressure (CPAP) and pneumothorax (PT) in term newborns. METHODS: Two studies performed in community hospitals used data extracted from computerized records of term newborns. Infants receiving positive pressure ventilation in the DR were excluded. Tabulated data included receipt of DR CPAP, PT on the day of birth, and gestational age (GA). In a case-control study from 2001-2013, infants with PT were compared to controls without PT but with respiratory distress or hypoxia persisting from birth for receipt of DR CPAP...
April 8, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28408827/photothermal-modulated-drug-delivery-and-magnetic-relaxation-based-on-collagen-poly-%C3%AE-glutamic-acid-hydrogel
#19
Sun-Hee Cho, Ahreum Kim, Woojung Shin, Min Beom Heo, Hyun Jong Noh, Kwan Soo Hong, Jee-Hyun Cho, Yong Taik Lim
Injectable and stimuli-responsive hydrogels have attracted attention in molecular imaging and drug delivery because encapsulated diagnostic or therapeutic components in the hydrogel can be used to image or change the microenvironment of the injection site by controlling various stimuli such as enzymes, temperature, pH, and photonic energy. In this study, we developed a novel injectable and photoresponsive composite hydrogel composed of anticancer drugs, imaging contrast agents, bio-derived collagen, and multifaceted anionic polypeptide, poly (γ-glutamic acid) (γ-PGA)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28406486/promoting-teamwork-may-improve-infant-care-processes-during-delivery-room-management-florida-perinatal-quality-collaborative-s-approach
#20
M Balakrishnan, N Falk-Smith, L A Detman, B Miladinovic, W M Sappenfield, J S Curran, T L Ashmeade
BACKGROUND: LOCAL PROBLEM: Inadequate understanding of compliance with standardized evidence-based DR management. INTERVENTIONS: Promote inter-professional teamwork and a bundle of interventions focusing on resuscitation team roles, equipment check, and debriefing using QI methodology. Optimize delivery room (DR) management to achieve 10-min SPO2 targets, delayed-cord clamping (DCC), team role assignment and debriefings in >50% of deliveries, and achieve normothermia in >75% of infants...
April 13, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
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