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https://www.readbyqxmd.com/read/29684622/injectable-drug-depot-engineered-to-release-multiple-ophthalmic-therapeutic-agents-with-precise-time-profiles-for-postoperative-treatment-following-ocular-surgery
#1
Maziar Mohammadi, Kisha Patel, Seyedeh P Alaie, Ron B Shmueli, Cagri G Besirli, Ronald G Larson, Jordan J Green
A multi-drug delivery platform is developed to address current shortcomings of post-operative ocular drug delivery. The sustained biodegradable drug release system is composed of biodegradable polymeric microparticles (MPs) incorporated into a bulk biodegradable hydrogel made from triblock copolymers with poly(ethylene glycol) (PEG) center blocks and hydrophobic biodegradable polyester blocks such as poly(lactide-co-glycolide) (PLGA), Poly(lactic acid) (PLA), or Poly(lactide-co-caprolactone) (PLCL) blocks. This system is engineered to flow as a liquid solution at room temperature for facile injection into the eye and then quickly gel as it warms to physiological body temperatures (approximately 37 °C)...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29683007/perioperative-noninvasive-cardiac-output-monitoring-in-parturients-undergoing-cesarean-delivery-with-spinal-anesthesia-and-prophylactic-phenylephrine-drip-a-prospective-observational-cohort-study
#2
Sharon Orbach-Zinger, Ilya Bizman, Shlomo Firman, Shaul Lev, Roi Gat, Eran Ashwal, Mordehay Vaturi, Eitan Razinski, Atara Davis, Anat Shmueli, Leonid A Eidelman
INTRODUCTION: Spinal anesthesia for cesarean delivery is associated with high incidence of hypotension and is most often prevented by a prophylactic phenylephrine infusion (PPI). In this study, we aimed to identify maternal hemodynamic changes both intraoperatively and postoperatively with the use of the NICaS noninvasive cardiac output monitor in healthy singleton parturients undergoing cesarean delivery (CD) with spinal anesthesia and PPI. METHODS: Healthy term women undergoing spinal anesthesia for singleton CD were enrolled...
April 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29682267/an-unusual-deceptive-delayed-of-profuse-haemorrhage-after-mandibular-implant-dentistry-risk-planning-and-medico-legal-instruction
#3
R M Gaudio, E El Haddad, G El Haddad, D Lauritano, F Carinci
Mandibular implant placement (MIP) has been accepted and widely used for decades all over the world, and has reached a very high level of therapeutic reliability. MIP is used mostly in elderly edentulous patients who lost their teeth when dentistry was not oriented to fixed or removable prosthetic. Notwithstanding this, every year cases of severe complications during MIP due to haemorrhage causing life-threatening airway's obstruction are reported. These severe complications of MIP need immediate therapy, usually with hospitalization, and may be potentially fatal...
October 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29681431/factors-associated-with-infant-pain-severity-undergoing-immunization-injections
#4
Manal Kassab, Shereen Hamadneh, Khawla Nuseir, Basima ALmomani, Jehan Hamadneh
PURPOSE: Factors influencing infants' behavioral and vocal (cry) response to painful stimuli are explored to improve pain management plans for infants undergoing immunizations. DESIGN AND METHODS: An observational study design was used. Pain responses of 60 to 75 days-old infants (44% male vs 56% female) undergoing two-month immunization injections were videotaped and coded using the Modified Behavioral Pain Scale (MBPS), and duration of total crying time during injection was recorded...
April 19, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29680471/the-neu-prem-trial-neuromonitoring-of-brains-of-infants-born-preterm-during-resuscitation-a-prospective-observational-cohort-study
#5
Anup C Katheria, M J Harbert, Sunil B Nagaraj, Kathy Arnell, Debra M Poeltler, Melissa K Brown, Wade Rich, Kasim O Hassen, Neil Finer
OBJECTIVE: To determine whether monitoring cerebral oxygen tissue saturation (StO2 ) with near-infrared spectroscopy (NIRS) and brain activity with amplitude-integrated electroencephalography (aEEG) can predict infants at risk for intraventricular hemorrhage (IVH) and death in the first 72 hours of life. STUDY DESIGN: A NIRS sensor and electroencephalography leads were placed on 127 newborns <32 weeks of gestational age at birth. Ten minutes of continuous NIRS and aEEG along with heart rate, peripheral arterial oxygen saturation, fraction of inspired oxygen, and mean airway pressure measurements were obtained in the delivery room...
April 16, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29673841/electrospun-silk-fibroin-fibers-for-storage-and-controlled-release-of-human-platelet-lysate
#6
Cataldo Pignatelli, Giovanni Perotto, Marta Nardini, Ranieri Cancedda, Maddalena Mastrogiacomo, Athanassia Athanassiou
Human platelet lysate (hPL) is a pool of growth factors and cytokines able to induce regeneration of different tissues. Despite its good potentiality as therapeutic tool for regenerative medicine applications, hPL has been only moderately exploited in this field. A more widespread adoption has been limited because of its rapid degradation at room temperature that decreases its functionality. Another limiting factor for its extensive use is the difficulty of handling the hPL gels. In this work, silk fibroin-based patches were developed to address several points: improving the handling of hPL, enabling their delivery in a controlled manner and facilitating their storage by creating a device ready to use with expanded shelf life...
April 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29669096/microdosimetric-measurement-of-secondary-radiation-in-the-passive-scattered-proton-therapy-room-of-ithemba-labs-using-a-tissue-equivalent-proportional-counter
#7
S Chiriotti, A Parisi, F Vanhavere, M De Saint-Hubert, C Vandevoorde, J Slabbert, P Beukes, E de Kock, J Symons
Measurements of the dose equivalent at different distances from the isocenter of the proton therapy center at iThemba LABS were previously performed with a tissue-equivalent proportional counter (TEPC). These measurements showed that the scattered radiation levels were one or two orders of magnitude higher in comparison to other passive scattering delivery systems. In order to reduce these radiation levels, additional shielding was installed shortly after the measurements were done. Therefore, the aim of this work is to quantify and assess the reduction of the secondary doses delivered in the proton therapy room at iThemba LABS after the installation of the additional shielding...
April 13, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29665070/a-time-to-be-born-variation-in-the-hour-of-birth-in-a-rural-population-of-northern-argentina
#8
Carlye Chaney, Laura G Goetz, Claudia Valeggia
OBJECTIVES: The present study aimed at investigating the timing of birth across the day in a rural population of indigenous and nonindigenous women in the province of Formosa, Argentina in order to explore the variation in patterns in a non-Western setting. MATERIALS AND METHODS: This study utilized birth record data transcribed from delivery room records at a rural hospital in the province of Formosa, northern Argentina. The sample included data for Criollo, Wichí, and Toba/Qom women (n = 2421)...
April 17, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29663698/comparative-study-of-two-droplet-based-dissolving-microneedle-fabrication-methods-for-skin-vaccination
#9
Chisong Lee, Hongil Kim, Suyong Kim, Shayan F Lahiji, Na-Young Ha, Huisuk Yang, Geonwoo Kang, Hai Yen Thi Nguyen, Yuri Kim, Myung-Sik Choi, Nam-Hyuk Cho, Hyungil Jung
Dissolving microneedles (DMNs) have been widely studied in medical applications due to their pain-free administration, superior efficiency, and safe drug delivery. In skin vaccination, preserving the activity of the encapsulated antigen is an important consideration, as antigen activity is lost during DMN fabrication because of various stress factors. These stress factors vary between fabrication methods and each method affects the antigen's activity to different degrees. In this study, the activity of encapsulated antigens delivered by DMNs is compared between two recently developed DMN fabrication methods; droplet-born air blowing (DAB) and centrifugal lithography (CL) for a model scrub typhus vaccine antigen, ScaA...
April 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29652878/prevalence-of-exclusive-breastfeeding-in-the-healthy-newborn
#10
Pedro Luis Del Mazo-Tomé, Marta Suárez-Rodríguez
Background: The best nourishment for infants during the first 6 months of life is exclusive breastfeeding. It is recommended along with other food to complement the diet until the child is 2 years old, as long as the mother and the child are willing to continue with it. The objectives of this study were to determine he exclusive breastfeeding rate in full term newborns at hospital discharge and 15 days later and to analyze the factors that positively affect the exclusive breastfeeding...
2018: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29629101/cooperative-loading-of-multisite-receptors-with-lanthanide-containers-an-approach-for-organized-luminescent-metallopolymers
#11
Lucille Babel, Laure Guénée, Céline Besnard, Svetlana V Eliseeva, Stéphane Petoud, Claude Piguet
Metal-containing (bio)organic polymers are materials of continuously increasing importance for applications in energy storage and conversion, drug delivery, shape-memory items, supported catalysts, organic conductors and smart photonic devices. The embodiment of luminescent components provides a revolution in lighting and signaling with the ever-increasing development of polymeric light-emitting devices. Despite the unique properties expected from the introduction of optically and magnetically active lanthanides into organic polymers, the deficient control of the metal loading currently limits their design to empirical and poorly reproducible materials...
January 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29628409/prospective-follow-up-of-a-cohort-of-preterm-infants-33-wg-receiving-ketamine-for-tracheal-intubation-in-the-delivery-room-neurological-outcome-at-1-and-2-years
#12
C Elalouf, A-G Le Moing, C Fontaine, A Leke, G Kongolo, J Gondry, P Tourneux
OBJECTIVE: Although ketamine analgesia is effective in reducing pain and facilitating the tracheal intubation of newborns in the delivery room, no data on the neurological effects of this treatment are available. This study compared the neurodevelopmental outcomes at 2 years of age in a cohort of preterm newborns having received ketamine prior to tracheal intubation at birth (the ketamine group) and in a control group. METHODS: We included newborns delivered at less than 33 weeks gestational age (WGA) having undergone tracheal intubation at birth...
April 5, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29615441/a-discrete-choice-experiment-to-determine-facility-based-delivery-services-desired-by-women-and-men-in-rural-ethiopia
#13
Nancy K Beam, Gezehegn Bekele Dadi, Sally H Rankin, Sandra Weiss, Bruce Cooper, Lisa M Thompson
OBJECTIVES: Despite global efforts to increase facility-based delivery (FBD), 90% of women in rural Ethiopia deliver at home without a skilled birth attendant. Men have an important role in increasing FBD due to their decision-making power, but this is largely unexplored. This study aimed to determine the FBD care attributes preferred by women and men, and whether poverty or household decision-making are associated with choice to deliver in a facility. SETTING AND PARTICIPANTS: We conducted a cross-sectional discrete choice experiment in 109 randomly selected households in rural Ethiopia in September-October 2015...
April 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29614329/presetting-ecg-electrodes-for-earlier-heart-rate-detection-in-the-delivery-room
#14
Rashmi Gulatia, Michael Zayeka, Fabien Eyala
AIM: To determine whether heart rate (HR) could be detected earlier than by pulse oximeter (POX), using a novel method of application of electrocardiogram (ECG) electrodes during neonatal resuscitation in the delivery room. METHODS: ECG electrodes were set before delivery to be applied to the back of infants' thorax. Time to detect HR was recorded as soon as a numerical HR along with a recognizable and persistent QRS complex was observed on ECG monitor (HRECG) and a plethysmographic waveform was seen on POX monitor (HRPOX)...
March 31, 2018: Resuscitation
https://www.readbyqxmd.com/read/29611563/liquid-metals-fundamentals-and-applications-in-chemistry
#15
REVIEW
T Daeneke, K Khoshmanesh, N Mahmood, I A de Castro, D Esrafilzadeh, S J Barrow, M D Dickey, K Kalantar-Zadeh
Post-transition elements, together with zinc-group metals and their alloys belong to an emerging class of materials with fascinating characteristics originating from their simultaneous metallic and liquid natures. These metals and alloys are characterised by having low melting points (i.e. between room temperature and 300 °C), making their liquid state accessible to practical applications in various fields of physical chemistry and synthesis. These materials can offer extraordinary capabilities in the synthesis of new materials, catalysis and can also enable novel applications including microfluidics, flexible electronics and drug delivery...
April 3, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29599442/on-chip-microfluidic-production-of-cell-sized-liposomes
#16
Siddharth Deshpande, Cees Dekker
In this protocol, we describe a recently developed on-chip microfluidic method to form monodisperse, cell-sized, unilamellar, and biocompatible liposomes with excellent encapsulation efficiency. Termed octanol-assisted liposome assembly (OLA), it resembles bubble-blowing on a microscopic scale. Hydrodynamic flow focusing of two immiscible fluid streams (an aqueous phase and a lipid-containing 1-octanol phase) by orthogonal outer aqueous streams gives rise to double-emulsion droplets. As the lipid bilayer assembles along the interface, each emulsion droplet quickly evolves into a liposome and a 1-octanol droplet...
May 2018: Nature Protocols
https://www.readbyqxmd.com/read/29599071/maintaining-normothermia-why-and-how
#17
Daniele Trevisanuto, Daniela Testoni, Maria Fernanda B de Almeida
A high incidence of postnatal hypothermia has been reported in high-as well low-resource countries and it remains an independent predictor of neonatal morbidity and mortality, especially in very preterm infants in all settings. The temperature of newly born infants should be maintained between 36.5 and 37.5 °C after birth through admission and stabilization. Interventions to achieve this may include environmental temperature 23-25 °C, use of radiant warmers, exothermic mattresses, woollen or plastic caps, plastic wraps, humidified and heated gases...
March 21, 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29595551/exploring-parent-experience-of-communication-about-therapeutic-hypothermia-in-the-neonatal-intensive-care-unit
#18
Alexa K Craig, Roslyn Gerwin, Janelle Bainter, Scott Evans, Christine James
BACKGROUND: The unique communication challenges faced by parents of infants undergoing therapeutic hypothermia have not been well characterized. PURPOSE: To develop awareness of communication challenges experienced by families of infants treated with therapeutic hypothermia. METHODS: Semistructured interviews were conducted in a group setting with parents matched into groups according to the severity of the infant's presenting encephalopathy...
April 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29588034/methods-for-defining-the-neuroprotective-properties-of-xenon
#19
Richie Robel, Peter Caroccio, Mervyn Maze
Xenon has features that make it an ideal general anesthetic agent; cost and scarcity mitigate xenon's widespread use in the operating room. Discovery of xenon's cytoprotective properties resulted in its application to thwart ongoing acute neurologic injury, an unmet clinical need. The discovery that xenon's neuroprotective effect interacts synergistically with targeted temperature management (TTM) led to its investigation in clinical settings, including in the management of the postcardiac arrest syndrome, in which TTM is indicated...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29584691/synthesis-self-assembly-and-drug-release-properties-of-new-amphipathic-liquid-crystal-polycarbonates
#20
Yujiao Xie, Xiaofeng Liu, Zhuang Hu, Zhipeng Hou, Zhihao Guo, Zhangpei Chen, Jianshe Hu, Liqun Yang
New amphiphilic liquid crystal (LC) polycarbonate block copolymers containing side-chain cholesteryl units were synthesized. Their structure, thermal stability, and LC phase behavior were characterized with Fourier transform infrared (FT-IR) spectrum, ¹H NMR, gel permeation chromatographic (GPC), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), polarizing optical microscope (POM), and XRD methods. The results demonstrated that the LC copolymers showed a double molecular arrangement of a smectic A phase at room temperature...
March 27, 2018: Nanomaterials
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