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https://www.readbyqxmd.com/read/29050375/interstitial-fluid-pressure-of-thymic-epithelial-tumours
#1
Takeshi Mori, Wataru Nishi, Tatsuya Yamada, Yamato Motooka, Koei Ikeda, Kenji Shiraishi, Makoto Suzuki
Tumours show an increased interstitial fluid pressure, which correlates with various pathophysiological features. Moreover, interstitial fluid pressure is a prognostic factor for cervical and lung cancer. However, there have been no reports on the usefulness of measuring interstitial fluid pressure in thymic epithelial tumours. Therefore, this study aimed to examine the relationship between interstitial fluid pressure and the clinicopathological characteristics of thymic epithelial tumours. Interstitial fluid pressure was prospectively measured at the centre of the tumour using a 1-Fr Mikro-Tip sensor catheter in 44 patients with thymic epithelial tumours, 40 with thymomas and 4 with thymic carcinomas...
August 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29050322/microrna-466-with-tumor-markers-for-cervical-cancer-screening
#2
Li-Li Zhou, Yong Shen, Jiao-Mei Gong, Ping Sun, Jia-He Sheng
Cervical cancer is the second most common cancer in women in the world. In this study, we explore tumor markers and microRNA-466 combination for cervical cancer screening. Tumor markers were measured by the methods of electro-chemiluminescent immunoassay and enzyme immunoassay. The microRNA-466 was performed by quantitative real-time polymerase chain reaction. Among normal group, hyperplasia group and cancer group, the CEA expression levels were 2.26 ng/ml, 3.85 ng/ml and 16.08 ng/ml, respectively. While the CA125 expression levels were 13...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050277/the-clinical-significance-of-hpip-and-the-associated-prognosis-in-cervical-cancer
#3
Fanling Meng, Haixia Liu, Shuang Liu, Rong Ma
Hematopoietic pre-B-cell leukemia transcription factor-interacting protein (HPIP), is known to promote tumor development and metastasis. However its role in cervical cancer remains unknown. The purpose of this study was to investigate the clinical significance of HPIP expression and the prognosis of patients with cervical cancer. Fresh frozen tissues from 10 samples of cervical cancer and 8normal cervical tissues were analyzed for HPIP expression using real-time reverse transcription PCR and Western blot analysis...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050093/-clinical-significance-of-lymphatic-metastasis-between-sternocleidomastoid-and-sternohyoid-muscle-in-papillary-thyroid-cancer
#4
S L Hao, H Q Sun, X C Liu, H J Chen, J Y Ning, G B Zheng, G C Wu, X C Song, H T Zheng
Objective: To explore the clinical significance of metastasis of lymph nodes between sternocleidomastoid and sternohyoid muscle (LNSS) in papillary thyroid cancer (PTC). Methods: A total of 175 patients with PTC who underwent thyroidectomy with LNSS dissection were retrospectively analyzed. Univariate and multivariate Logistic regression analyses were used to determine the independent risk factors for LNSS metastasis in PTC. Results: The rate of detectable LNSS was 70.9% (124/175) and metastasis rate was 7...
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29049940/photocatalytic-degradation-of-synthetic-food-dye-sunset-yellow-fcf-fd-c-yellow-no-6-by-ailanthus-excelsa-roxb-possessing-antioxidant-and-cytotoxic-activity
#5
Subramanyam Deepika, Rajendran Harishkumar, Murugesan Dinesh, Rajadurai Abarna, Moorthy Anbalagan, Selvaraj Mohana Roopan, Chinnadurai Immanuel Selvaraj
The purpose of our work is to identify the bioactive compounds of bark and leaves extract from Ailanthus excelsa Roxb. and to explore its effectiveness against synthetic food dye. The presence of primary and secondary metabolites was confirmed by carrying out phytochemicals analysis. With the prior knowledge accessible on the indispensable secondary metabolites holding antioxidant and cytotoxicity activity, the quantitative screening of total phenolic and flavonoid content in methanolic and aqueous extract of bark and leaves from Ailanthus excelsa were done...
October 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29049093/association-of-metformin-use-and-survival-outcome-in-women-with-cervical-cancer
#6
Tsuyoshi Takiuchi, Hiroko Machida, Marianne S Hom, Sayedamin Mostofizadeh, Marina Frimer, Laurie L Brunette, Koji Matsuo
OBJECTIVE: Although preclinical studies suggest possible antitumor effects of metformin against cervical cancer, there is currently a lack of clinical data examining the association of metformin use and survival in women with cervical cancer. The aim of this study was to examine survival of women with cervical cancer who were receiving metformin. METHODS: This is a retrospective study examining consecutive cases of stages I to IV cervical cancer between 2000 and 2014...
September 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29049007/low-prevalence-of-vaccine-type-hpv-infections-in-young-women-following-the-implementation-of-a-school-based-and-catch-up-vaccination-in-quebec-canada
#7
P Goggin, C Sauvageau, V Gilca, F Defay, G Lambert, S Mathieu-C, J Guenoun, E Comète, F Coutlée
BACKGROUND: In Quebec, Canada, a school-based HPV vaccination for girls has been offered since 2008. The vaccine used in the program targets HPV16/18, responsible for ∼70% of cervical cancers and HPV6/11, responsible for the majority of anogenital warts. The objective of this study was to assess the prevalence of HPV in vaccinated and unvaccinated women. METHODS: Women aged 17-29 years were eligible to participate. Participants' age, vaccination status and diverse risk factors were assessed by a computer-assisted questionnaire...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29048994/awareness-of-and-willingness-to-be-vaccinated-by-human-papillomavirus-vaccine-among-junior-middle-school-students-in-jinan-china
#8
Li Xue, Wenqi Hu, Haiman Zhang, Zhongling Xie, Xi Zhang, Fanghui Zhao, Youlin Qiao, Lijie Gao, Wei Ma
BACKGROUND: Willingness to be vaccinated with human papillomavirus (HPV) vaccine among junior middle school students in China is not well understood. We conducted a cross-sectional study to assess awareness of HPV and the HPV vaccine and explore the factors associated with willingness to be vaccinated. METHODS: First-year students from two junior middle schools in Jinan, China were selected by cluster sampling on December 28, 2015, December 26, 2016, and January 11, 2017, and a self-administered questionnaire was used to collect information...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29048733/cytology-and-high-risk-hpv-testing-in-cervical-cancer-screening-program-outcome-of-3-year-follow-up-in-an-academic-institute
#9
Jack Yang, Fredrick S Nolte, Olga S Chajewski, Kathryn G Lindsey, Patricia M Houser, Jalidsa Pellicier, Qun Wang, Laleh Ehsani
BACKGROUND: Combination of cervical cytology and high-risk human papillomavirus (HR-HPV) testing, co-testing, has been increasingly used in screening cervical cancers. The present study summarized the outcome of co-testing by reviewing 3-year clinical and pathological follow-up information. METHODS: Patients were retrospectively identified via computerized search and were grouped based on the cytologic diagnosis and HR-HPV status as negative for intraepithelial lesion or malignancy (NILM)/HPV-, NILM/HPV+, atypical squamous cells of undetermined significance (ASC-US)/HPV-, ASC-US/HPV+, low grade squamous intraepithelial lesion (LSIL)/HPV-, LSIL/HPV+, atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion (ASC-H)/HPV-, ASC-H/HPV+, high grade squamous intraepithelial lesion (HSIL)/HPV-, and HSIL/HPV+...
October 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29048651/inhibitor-of-%C3%AE-catenin-and-tcf-icat-promotes-cervical-cancer-growth-and-metastasis-by-disrupting-e-cadherin-%C3%AE-catenin-complex
#10
Yayun Jiang, Wei Ren, Weijia Wang, Jing Xia, Liyao Gou, Mengyao Liu, Qun Wan, Lan Zhou, Yaguang Weng, Tongchuan He, Yan Zhang
The inhibitor of β-catenin and TCF (ICAT) blocks the binding of TCF to β-catenin and has been demonstrated as a suppressor of the Wnt/β-catenin signaling pathway. It has been reported to exert a different function around a wide variety of cancers. However, its function and underlying mechanisms in human cervical cancer remains unknown. In the present study, the expression of ICAT in 41 human cervical cancer tissues and 30 normal cervical tissues was evaluated by immunohistochemical analysis. ICAT was found highly expressed in cancer tissues...
September 18, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048632/microrna-1297-inhibits-metastasis-and-epithelial-mesenchymal-transition-by-targeting-aeg-1-in-cervical-cancer
#11
Zengyan Wang, Shanyang He, Peng Guo, Xu Guo, Jingxuan Zheng
Accumulating evidence has demonstrated that aberrant miRNAs contribute to cervical cancer (CC) development and progression. However, the roles of various miRNAs in CC remain to be determined. In the present study, we confirmed that a decreased miR-1297 expression was present in CC tissues and cell lines. Our clinical analysis revealed that the downregulated miR-1297 expression was significantly correlated with poor prognostic features including lymph node metastasis and lymphovascular space invasion. Moreover, we confirmed that miR-1297 was a novel independent prognostic marker for predicting the 5-year survival of CC patients...
September 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048616/the-receptor-for-activated-protein-kinase-c-promotes-cell-growth-invasion-and-migration-in-cervical-cancer
#12
Shan Liao, Songshu Xiao, Hongxiang Chen, Manying Zhang, Zhifang Chen, Yuehua Long, Lu Gao, Junyu He, Yanshan Ge, Wei Yi, Minghua Wu, Guiyuan Li, Yanhong Zhou
Cervical cancer is one of the most common malignant tumors in women all over the world. However, the exact etiology of cervical cancer remains unclear. The receptor for activated protein kinase C (RACK1) is reported to be involved in tumorigenesis and tumor progression. Besides, the prognostic value of RACK1 in several kinds of tumors has been identified. However, there are limited studies on the functional role of RACK1 in cervical cancer. In this study, we tested the expression level of RACK1 by immunohistochemistry and western blot technologies and find that it is upregulated in cervical cancer...
September 27, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29047326/integrating-chws-as-part-of-the-team-leading-diabetes-group-visits-a-randomized-controlled-feasibility-study
#13
Elizabeth M Vaughan, Craig A Johnston, Victor J Cardenas, Jennette P Moreno, John P Foreyt
Purpose The purpose of the study was to evaluate the feasibility of integrating Community Health Workers (CHWs) as part of the team leading diabetes group visits. Methods This was a randomized controlled study that integrated CHWs as part of the team leading diabetes group visits for low-income Hispanic adults (n = 50). Group visits met for 3 hours each month for a 6-month duration. Main measures included baseline and 6-month clinical outcomes (ie, A1C, lipids), concordance with 8 standard of care guidelines (ie, screens for cervical, breast, and colon cancer) from the US Preventive Task Force and American Diabetes Association, and participant acceptability...
October 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/29047044/exosomes-for-the-enhanced-tissue-bioavailability-and-efficacy-of-curcumin
#14
Farrukh Aqil, Radha Munagala, Jeyaprakash Jeyabalan, Ashish Kumar Agrawal, Ramesh Gupta
Exosomes are extracellular microvesicles with a particle size of 30-100 nm and carry a cargo of proteins, lipids, RNA, and DNA. Their properties of shuttling in-and-out of the cells suggest that these particles can be exploited as a nano drug carrier. In this manuscript, we show that curcumin can be delivered effectively using milk-derived exosomes. Curcumin when mixed with exosomes in the presence of 10% ethanol:acetonitrile (1:1) provided a drug load of 18-24%, and the formulation stored at - 80°C was stable for 6 months as determined by particle size analysis, drug load, and antiproliferative activity...
October 18, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29046833/optical-techniques-for-cervical-neoplasia-detection
#15
REVIEW
Tatiana Novikova
This paper provides an overview of the current research in the field of optical techniques for cervical neoplasia detection and covers a wide range of the existing and emerging technologies. Using colposcopy, a visual inspection of the uterine cervix with a colposcope (a binocular microscope with 3- to 15-fold magnification), has proven to be an efficient approach for the detection of invasive cancer. Nevertheless, the development of a reliable and cost-effective technique for the identification of precancerous lesions, confined to the epithelium (cervical intraepithelial neoplasia) still remains a challenging problem...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29045918/cervical-cancer-cells-hela-response-to-photodynamic-therapy-using-a-zinc-phthalocyanine-photosensitizer
#16
Natasha Hodgkinson, Cherie Ann Kruger, Mpho Mokwena, Heidi Abrahamse
Cervical cancer is the most common gynecological malignancy worldwide, and the leading cause of cancer related deaths among females. Conventional treatment for early cervical cancer is radical hysterectomy. In locally advanced cancer the treatment of choice is concurrent chemo radiation. Although such treatment methods show promise, they do have adverse side effects. To minimize these effects, as well as prevent cancer re-occurrence, new treatment methods are being investigated. Photodynamic therapy (PDT) involves the selective uptake of a photosensitizer (PS) by cancer cells, illumination with light of an appropriate wavelength that triggers a photochemical reaction leading to the generation of reactive oxygen and subsequent tumor regression...
October 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29045464/tip60-represses-telomerase-expression-by-inhibiting-sp1-binding-to-the-tert-promoter
#17
Deepa Rajagopalan, Amit Kumar Pandey, Magdalene Claire Xiuzhen, Kwok Kin Lee, Shainan Hora, Yanzhou Zhang, Boon Haow Chua, Hui Si Kwok, Shreshtha Sailesh Bhatia, Lih Wen Deng, Daniel G Tenen, Dennis Kappei, Sudhakar Jha
HIV1-TAT interacting protein (TIP60) is a haploinsufficient tumor suppressor. However, the potential mechanisms endowing its tumor suppressor ability remain incompletely understood. It plays a vital role in virus-induced cancers where TIP60 down-regulates the expression of human papillomavirus (HPV) oncoprotein E6 which in turn destabilizes TIP60. This intrigued us to identify the role of TIP60, in the context of a viral infection, where it is targeted by oncoproteins. Through an array of molecular biology techniques such as Chromatin immunoprecipitation, expression analysis and mass spectrometry, we establish the hitherto unknown role of TIP60 in repressing the expression of the catalytic subunit of the human telomerase complex, TERT, a key driver for immortalization...
October 18, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#18
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29044755/epoxyazadiradione-purified-from-the-azadirachta-indica-seed-induced-mitochondrial-apoptosis-and-inhibition-of-nf%C3%AE%C2%BAb-nuclear-translocation-in-human-cervical-cancer-cells
#19
G Shilpa, J Renjitha, R Saranga, Francis K Sajin, Mangalam S Nair, Beena Joy, B S Sasidhar, S Priya
Epoxyazadiradione (EAD) is an important limonoid present in Neem (Azadirachta indica) plant. In the present study, we have purified EAD from Neem seed and studied its anticancer potential in human cervical cancer (HeLa) cells. Cell proliferation inhibition studies indicated that the GI50 value of EAD is 7.5 ± 0.0092 μM in HeLa cells, whereas up to 50 μM concentrations EAD did not affect the growth of normal H9C2 cells. The control drug cisplatin inhibited the growth of both HeLa and H9C2 cells with a GI50 value of 2...
October 18, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29043926/efficient-induction-of-apoptosis-in-cancer-cells-by-paclitaxel-loaded-selenium-nanoparticles
#20
Anil Parsram Bidkar, Pallab Sanpui, Siddhartha Sankar Ghosh
AIM: To develop selenium nanoparticles (SeNPs)-based delivery systems for paclitaxel (PTX) and assess their antiproliferative efficacy against cancer cells in vitro with potential mechanistic insight. METHODS: Pluronic F-127 stabilized SeNPs were prepared and characterized. Effects of PTX-loaded SeNPs on lung (A549), breast (MCF7), cervical (HeLa) and colon (HT29) cancer cells were studied by viability assay complemented with flow-cytometric analyses of cell cycle, apoptosis, mitochondrial membrane potential, intracellular reactive oxygen species and caspase activity...
October 18, 2017: Nanomedicine
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