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Cervical cancer

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https://www.readbyqxmd.com/read/29677009/cervical-cancer-screening-in-women-with-severe-mental-disorders-an-approach-to-the-spanish-context
#1
Jessica Borrull-Guardeño, Alberto Domínguez, Milton H Merizalde-Torres, Vanessa Sánchez-Martínez
BACKGROUND: The incidence of invasive cervical cancer and its mortality have been reduced through primary and secondary prevention. Screening rates tend to be lower in vulnerable groups, such as people with severe mental disorders, who have a later detection of cancer and a higher mortality. The access of these women to cervical cancer screening is uncertain in our context. OBJECTIVE: The aim of this study was to determine the cervical cancer screening rates in women with severe mental disorders...
April 19, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29675996/streptococcus-endopeptidases-promote-hpv-infection-in-vitro
#2
Sylvia I Pavlova, Reid V Wilkening, Michael J Federle, Yu Lu, Joel Schwartz, Lin Tao
Both cervical and throat cancers are associated with human papillomavirus (HPV). HPV infection requires cleavage of the minor capsid protein L2 by furin. While furin is present in the vaginal epithelium, it is absent in oral epithelial basal cells where HPV infection occurs. The objective of this study was to investigate whether common oral bacteria express furin-like peptidases. By screening strains representing 12 oral Streptococcus and Enterococcus species, we identified that eight Streptococcus strains displayed high levels of furin-like peptidase activity, with S...
April 19, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29675109/wnt-signaling-in-cervical-cancer
#3
REVIEW
Min Yang, Min Wang, Xianping Li, Yixin Xie, Xiaomeng Xia, Jingjing Tian, Kan Zhang, Aiguo Tang
Cervical cancer (CC) is the second most common malignant cancer in women. CC is difficult to diagnose, has a high recurrence rate, and is resistant to systemic therapies; as a result, CC patients have a relatively poor prognosis. One potential link to CC is the Wnt signaling pathway and its downstream effectors, which regulate cell differentiation, proliferation, migration, and fate. The aberrant activation of Wnt signaling is associated with various cancers, including CC. Recent studies have shown that activating or inhibiting the intracellular signal transduction in this pathway can regulate cancer cell growth and viability...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29673740/recent-intrauterine-device-use-and-the-risk-of-precancerous-cervical-lesions-and-cervical-cancer
#4
Sarah Averbach, Michael J Silverberg, Wendy Leyden, Karen Smith-McCune, Tina Raine-Bennett, George F Sawaya
OBJECTIVE: Understanding the effect of contraceptives on the development of precancerous lesions of the cervix and cervical cancer may provide information that is valuable to women in contraceptive decision-making. The purpose of this study was to evaluate the association between recent intrauterine device (IUD) use (by type) and cervical intraepithelial neoplasia 2, 3, adenocarcinoma in situ or cancer (CIN2+ or CIN3+). STUDY DESIGN: Case-control study of 17,559 women age 18-49 with incident CIN2+ cases and 5:1 age-matched, incidence-density selected controls (N=87,378) who were members of Kaiser Permanente Northern California Healthcare System from 1996-2014...
April 16, 2018: Contraception
https://www.readbyqxmd.com/read/29673457/-mir-182-promotes-cell-proliferation-of-cervical-cancer-cells-by-targeting-adenomatous-polyposis-coli-apc-gene
#5
Pei Li, Jing Hu, Ying Zhang, Jianping Li, Yunzhi Dang, Rui Zhang, Lichun Wei, Mei Shi
Objective To investigate the role and mechanism of microRNA-182 (miR-182) in the proliferation of cervical cancer cells. Methods With liposome-mediated transient transfection method, the level of miR-182 in HeLa and SiHa cells was increased or decreased. CCK-8 assay and colony formation assay were used to observe the effect of miR-182 on the proliferation of cervical cancer cells. Using bioinformatics predictions, real-time quantitative PCR, and dual luciferase reporter assay, we clarified the role of miR-182 in posttranscriptional regulation of adenomatous polyposis coli (APC) gene and its effect on the downstream molecules (c-Myc and cyclin D1) of Wnt singling pathway...
February 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29672633/design-synthesis-dft-docking-studies-and-adme-prediction-of-some-new-coumarinyl-linked-pyrazolylthiazoles-potential-standalone-or-adjuvant-antimicrobial-agents
#6
Sunil Kumar, Vikram Saini, Indresh K Maurya, Jayant Sindhu, Mukesh Kumari, Ramesh Kataria, Vinod Kumar
The control of antimicrobial resistance (AMR) seems to have come to a dead end. The major consequences of the use and abuse of antibacterial drugs are the development of resistant strains due to genetic mutability of both pathogenic and nonpathogenic microorganisms. We, herein, report the synthesis, characterization and biological activities of coumarin-thiazole-pyrazole (CTP) molecular hybrids with an effort to explore and overcome the increasing antimicrobial resistance. The compounds were characterized by analyzing their IR, Mass, 1H and13C NMR spectral data and elemental analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29672463/limited-additional-value-of-cervical-ultrasonography-over-a-negative-18f-fdg-pet-ct-for-diagnosing-cervical-lymph-node-metastases-in-patients-with-esophageal-cancer-a-systematic-review-and-meta-analysis
#7
Lucas Goense, Jihane Meziani, Peter S N van Rossum, Frank J Wessels, Gert J Meijer, Marnix G E H Lam, Richard van Hillegersberg, Jelle P Ruurda
OBJECTIVE: To assess the additional value of cervical ultrasonography as supplement to a negative fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) for detecting cervical lymph node metastases during the initial staging of patients with esophageal cancer. METHODS: PubMed/Medline, Embase, and the Cochrane library were systematically searched. The analysis included diagnostic studies describing the accuracy of cervical ultrasonography and integrated F-FDG PET/CT or standalone F-FDG PET and CT for detecting cervical lymph node metastases in patients with esophageal cancer...
April 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29672447/effects-of-human-papillomavirus-awareness-and-knowledge-on-psychological-state-of-women-referred-to-cervical-cancer-screening
#8
Ljiljana Markovic-Denic, Olivera Djuric, Natasa Maksimovic, Svetlana Popovac, Vesna Kesic
OBJECTIVE: The aim of the study was to assess the impact of human papillomavirus (HPV) awareness and knowledge on physiological state and quality of life of women referred to colposcopy and/or HPV testing. MATERIALS AND METHODS: A cross-sectional study was carried out at University Hospital, Belgrade, Serbia. The women with abnormal Pap test results obtained at the primary care centers requiring colposcopy and/or HPV testing were included. Before gynecological examination, participants filled the questionnaire on demographic characteristics, gynecological history, questionnaire for the evaluation of HPV awareness and HPV knowledge level, a set of self-report questionnaires assessing the anxiety level, quality of life, and concern about the smear and colposcopy results and perceived risk of developing cervical cancer...
April 19, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29671791/the-antecedents-and-consequences-of-health-literacy-in-an-ecological-perspective-results-from-an-experimental-analysis
#9
Chiara Lorini, Francesca Ierardi, Letizia Bachini, Martina Donzellini, Fabrizio Gemmi, Guglielmo Bonaccorsi
This study analyses the relationship between the antecedents and consequences of health literacy (HL) at the ecological level among the nations involved in the European Health Literacy Survey (HLS-EU). The antecedents and consequences were investigated by means of proxy indicators. The HL was measured using the 47-item HLS-EU questionnaire (HLS-EUQ47) and the Newest Vital Sign (NVS). The two measures stood in significant correlation to the outcomes of the sub-discipline of the Euro Health Consumer Index (r = 0...
April 19, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29671553/cervical-cancer-screening
#10
Caitlyn M Rerucha, Rebecca J Caro, Vernon L Wheeler
Screening in women has decreased the incidence and mortality of cervical cancer. Precancerous cervical lesions (cervical intraepithelial neoplasias) and cervical carcinomas are strongly associated with sexually-transmitted high-risk human papillomavirus (HPV) infection, which causes more than 99% of cervical cancers. Screening methods include cytology (Papanicolaou test) and HPV testing, alone or in combination. The American Academy of Family Physicians and the U.S. Preventive Services Task Force recommend starting screening in immunocompetent, asymptomatic women at 21 years of age...
April 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671552/cervical-cancer-evaluation-and-management
#11
Jennifer Wipperman, Tara Neil, Tracy Williams
Human papillomavirus infection is the precursor for the development of cervical cancer and is detectable in 99.7% of squamous cell carcinoma and adenocarcinoma cases. Early detection of precancerous lesions with Papanicolaou testing remains the primary mechanism for cancer prevention. Once cervical cancer is diagnosed, treatment may involve surgery, radiation therapy, chemotherapy, or a combination. The choice of therapy depends on the stage of disease, lymph node involvement, patient comorbidities, and risk factors for recurrence...
April 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671223/laparoscopic-paraaortic-surgical-staging-in-locally-advanced-cervical-cancer-a-single-center-experience
#12
D Vázquez-Vicente, B Fernández Del Bas, J García Villayzán, H A Di Fiore, J Luna Tirado, V Casado Echarren, J García-Foncillas, J Plaza Arranz, L Chiva
BACKGROUND: One aim of this study was to assess the efficacy and safety of laparoscopic paraaortic lymphadenectomy for paraaortic lymph node staging in locally advanced cervical carcinoma. The second aim was to identify prognostic factors in the evolution of this disease and to evaluate how the results of the surgery modify the oncological treatment of patients. MATERIALS AND METHODS: We analyzed 59 patients diagnosed with locally advanced cervical cancer International Federation of Gynecology and Obstetrics stage IB2-IVA who underwent laparoscopic paraaortic lymphadenectomy at our hospital between 2009 and 2015...
April 18, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29671198/cancer-community-education-in-somali-refugees-in-nebraska
#13
Shinobu Watanabe-Galloway, Nada Alnaji, Brandon Grimm, Melissa Leypoldt
Nebraska has one of the highest numbers of refugees per capita in the U.S. A high number of Somalis have resettled in Nebraska due to job opportunities and the low cost of living. In this paper, we report the process and the results of a cervical and breast cancer education program for Somali women conducted through a collaboration among public health, academia, and community entities. The curriculum was built to be suitable for the literacy level and cultural values of this community. Topics include female reproductive anatomy; breast and cervical cancer knowledge and screening; hepatitis C and liver cancer; and preparing for a health screening visit...
April 18, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29670794/coexistence-of-cervical-leiomyosarcoma-and-gastric-type-adenocarcinoma-in-situ-with-extensive-extension-to-the-endometrium-and-fallopian-tube
#14
Ayako Ura, Kanako Ogura, Asumi Sakaguchi, Hiroko Onagi, Daiki Ogishima, Yayoi Sugimori, Kensuke Hamamura, Masaharu Fukunaga, Toshiharu Matsumoto
Cervical leiomyosarcoma is known to be rare from the previous reviews of a large number of malignant cervical tumors. The patient was a 66-year-old woman with irregular vaginal bleeding. She underwent modified radical hysterectomy and bilateral salpingooophorectomy. Histopathologically, we diagnosed the coexistence of uterine cervical leiomyosarcoma and cervical gastric-type adenocarcinoma in situ with endometrial lesions that had continuous and skip patterns and fallopian tubal lesions with a partial lesion...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29670400/-anln-functions-as-a-key-candidate-gene-in-cervical-cancer-as-determined-by-integrated-bioinformatic-analysis
#15
Leilei Xia, Xiaoling Su, Jizi Shen, Qi Meng, Jiuqiong Yan, Caihong Zhang, Yu Chen, Han Wang, Mingjuan Xu
Background: Cervical cancer, one of the leading causes of female deaths, remains a top cause of mortality in gynecologic oncology and tends to affect younger individuals. However, the pathogenesis of cervical cancer is still far from clear. Given the high incidence and mortality of cervical cancer, uncovering the causes and pathogenesis as well as identifying novel biomarkers are of great significance and are desperately needed. Materials and methods: First, raw data were downloaded from the Gene Expression Omnibus database...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29669936/engineered-t-cells-targeting-e7-mediate-regression-of-human-papillomavirus-cancers-in-a-murine-model
#16
Benjamin Y Jin, Tracy E Campbell, Lindsey M Draper, Sanja Stevanović, Bianca Weissbrich, Zhiya Yu, Nicholas P Restifo, Steven A Rosenberg, Cornelia L Trimble, Christian S Hinrichs
T cell receptor (TCR) T cell therapy is a promising cancer treatment modality. However, its successful development for epithelial cancers may depend on the identification of high-avidity TCRs directed against tumor-restricted target antigens. The human papillomavirus (HPV) E7 antigen is an attractive therapeutic target that is constitutively expressed by HPV+ cancers but not by healthy tissues. It is unknown if genetically engineered TCR T cells that target E7 can mediate regression of HPV+ cancers. We identified an HPV-16 E7-specific, HLA-A*02:01-restricted TCR from a uterine cervix biopsy from a woman with cervical intraepithelial neoplasia...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29668969/liquid-based-cytology-versus-conventional-cytology-for-detection-of-uterine-cervical-lesions-a-prospective-observational-study
#17
Hiroshi Nishio, Takashi Iwata, Hidetaka Nomura, Tohru Morisada, Nobuhiro Takeshima, Hirokuni Takano, Hiroshi Sasaki, Eiji Nakatani, Satoshi Teramukai, Daisuke Aoki
Objective: Liquid-based cytology (LBC) and conventional cytology (CS) are routine diagnostic techniques in cervical cytology, but few studies have compared their diagnostic performances with each other and with histologic diagnosis. This study aimed to compare the diagnostic performances of these techniques in subjects with abnormal cervical cytology of atypical cells of undetermined significance (ASC-US) or worse. Methods: A total of 312 patients diagnosed with ASC-US or worse were enrolled in this prospective study in Japan from 2013 to 2014...
April 13, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29668638/clinical-impact-of-boost-irradiation-to-pelvic-lymph-node-in-uterine-cervical-cancer-treated-with-definitive-chemoradiotherapy
#18
Kyu Hye Choi, Ji Yoon Kim, Dong Soo Lee, Yun Hee Lee, Sea-Won Lee, SooYoon Sung, Hee Hyun Park, Sei-Chul Yoon, Soo Young Hur, Jong-Sup Park, Yeon Sil Kim
The aim of this study was to analyze tumor control and clinical outcomes of patients with uterine cervical cancer treated by chemoradiotherapy according to pelvic lymph node (PLN) positivity and boost irradiation to PLN and to determine toxicities associated with boost irradiation.We retrospectively reviewed patients with uterine cervical cancer treated with chemoradiotherapy between March 2000 and April 2015. Clinical characteristics, failure pattern, and survival outcomes of patients with or without PLN metastasis and those with or without boost irradiation were analyzed...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668599/which-is-better-for-predicting-pelvic-lymph-node-metastases-in-patients-with-cervical-cancer-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-or-a-sentinel-node-biopsy-a-retrospective-observational-study
#19
Tomohito Tanaka, Shun Sasaki, Hiromitsu Tsuchihashi, Yoshito Terai, Kazuhiro Yamamoto, Takashi Yamada, Masahide Ohmichi
Systematic pelvic lymph node resection may not be needed for patients with cervical cancer, especially in the early stage, if the pre- or intraoperative diagnosis of lymph node status is correct. The aim of this study was to evaluate the diagnostic accuracy of pelvic lymph node metastasis for fluorodeoxyglucose-positron emission tomography/computed tomography (FDG PET/CT) and sentinel node biopsy (SNB) of cervical cancer patients.Forty-eight patients with cervical cancer were imaged with FDG PET/CT before radical hysterectomy and underwent an SNB followed by systematic pelvic lymph node dissection...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668478/correlation-of-htert-expression-with-cervical-cytological-abnormalities-and-human-papillomavirus-infection
#20
Vjosa A Zejnullahu, Valon A Zejnullahu, Slavica Josifovska, Nikola Vukovik, Kiril Pakovski, Sasho Panov
Telomerase Reverse Transcriptase (TERT) is the main catalytic sub-unit of telomerase, a reverse transcriptase enzyme. Telomerase expression is regulated at many levels, with numerous studies suggesting that up-regulation of human TERT gene (hTERT) at transcriptional level results in immortal cell phenotype associated with cancer. The aim of this study is to determine the correlation between hTERT expression and different cervical precursor lesions, as well as with cervical cancer in patients with confirmed Human papillomavirus (HPV) infection...
December 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
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