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Cervical cancer

Wanxue Wang, Zhenni Yue, Zhengping Tian, Yiran Xie, Jiamiao Zhang, Yuanping She, Bing Yang, Yuan Ye, Yihua Yang
The molecular mechanisms of normal cervical squamous epithelium advancing to cervical intraepithelial neoplasia (CIN) and eventually to cervical squamous cell carcinoma (CSCC) are largely unknown. This study explored abnormal expression of Yin Yang 1 (YY1) in cervical cancer and its correlation with the expression of E-cadherin and human papillomavirus (HPV) 16 E6. YY1, E-cadherin and HPV16 E6 expression were detected by immunohistochemistry in 90 cervical tissue specimens collected from 30 patients with hysteromyoma, 15 patients with CIN I, 15 patients with CIN II-III, and 30 patients with CSCC...
2018: PloS One
Salih Taşkin, Duygu Altin, Yavuz Emre Şükür, Firat Ortaç
OBJECTIVE: The aim of the study was to evaluate extrapelvic sentinel lymph nodes (SLNs) in clinical early-stage endometrial cancer patients with unmapped pelvic side(s) during fluorescent imaging-based sentinel mapping. MATERIALS AND METHODS: Eligible patients underwent sentinel mapping using cervical injection of indocyanine green and near-infrared florescent imaging compatible endoscopic systems. Pelvic SLNs were identified and resected. If bilateral mapping was not achieved, upper lymph nodes areas including presacral, upper common iliac, and para-aortic caval regions were explored for any SLN...
February 22, 2018: International Journal of Gynecological Cancer
Lene Seibæk, Dorthe Hjort Jakobsen, Claus Høgdall
OBJECTIVE: Quality of preoperative and postoperative care is crucial to improve postoperative outcome of cancer surgery and to ensure that neither complications nor a poor general condition delays any subsequent radiochemotherapy or recovery. On this background, the Danish Gynecological Cancer Database (DGCD) established a nursing database in 2011. The aim of DGCD Nursing is to monitor the quality of preoperative and postoperative care and to generate data for research. MATERIAL AND METHODS: In accordance with the current data protection legislation, real-time data are entered by clinical nurses at all national cancer centers...
February 22, 2018: International Journal of Gynecological Cancer
John Heintzman, Brigit Hatch, Gloria Coronado, David Ezekiel, Stuart Cowburn, Octavio Escamilla-Sanchez, Miguel Marino
INTRODUCTION: Hispanic women in the United States have an elevated risk of cervical cancer, but the existing literature does not reveal why this disparity persists. METHODS: We performed a retrospective cohort analysis of 17,828 low-income women aged 21 to 64 years seeking care at Oregon community health centers served by a hosted, linked electronic health record during 2009 through 2013. We assessed the odds of having had Papanicolaou (Pap) tests and receiving human papillomavirus (HPV) vaccine, by race/ethnicity, insurance status, and language...
February 22, 2018: Preventing Chronic Disease
Philip M Massey, Alex Budenz, Amy Leader, Kara Fisher, Ann C Klassen, Elad Yom-Tov
INTRODUCTION: We conducted this study to quantify how health professionals use Twitter to communicate about the human papillomavirus (HPV) vaccine. METHODS: We collected 193,379 tweets from August 2014 through July 2015 that contained key words related to HPV vaccine. We classified all tweets on the basis of user, audience, sentiment, content, and vaccine characteristic to examine 3 groups of tweets: 1) those sent by health professionals, 2) those intended for parents, and 3) those sent by health professionals and intended for parents...
February 22, 2018: Preventing Chronic Disease
Tessa S Cook
Cancer screening initiatives exist around the world for different malignancies, most frequently breast, colorectal, and cervical cancer. A number of cancer registries exist to collect relevant data, but while these data may include imaging findings, they rarely, if ever, include actual images. Additionally, the data submitted to the registry are usually correlated with eventual cancer diagnoses and patient outcomes, rather than used with the individual's future screenings. Developing screening programs that allow for images to be submitted to a central location in addition to patient meta-data and used for comparison to future screening exams would be very valuable in increasing access to care and ensuring that individuals are effectively screened from year to year...
February 22, 2018: British Journal of Radiology
Octavian Constantin Neagoe, Mihaela Ionica, Dorin Nicolae Agapie
PURPOSE: Due to the rarity of vaginal cancer, surgical treatment results, and postoperative complications have been poorly described in the literature. The aim of this study was to improve current knowledge about the incidence of hydronephrosis following the surgical treatment of vaginal cancer. MATERIALS AND METHODS: 32 patients with vaginal cancer of the middle and upper third were matched with 32 cervical cancer patients (stages I and II) for comparison of long-term urological postoperative complications...
February 22, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
G Narayana, M Jyothi Suchitra, G Sunanda, J Dasaratha Ramaiah, B Pradeep Kumar, K V Veerabhadrappa
INTRODUCTION: Cervical cancer-related deaths among women in India are often due to late diagnosis of disease. Knowledge about disease and early screening is the most effective measure for cervical cancer prevention. Lack of awareness, negative attitude, and poor practice about cervical cancer and screening are the major causes to increase the incidence of disease. AIM: The study is designed to assess knowledge, attitude, and practice (KAP) toward cervical cancer, screening, and prevention...
April 2017: Indian Journal of Cancer
S C Jayasankaran, P G Chelakkot, K Thankappan, S Iyer, S Moorthy
BACKGROUND: Magnetic resonance imaging (MRI) in tumors of anterior two-thirds of tongue has a significant role in assessing different tumor parameters, and in prognosticating. AIM: This prospective study conducted in a tertiary cancer care center, focused on patients with squamous cell carcinoma of anterior two-thirds of tongue. The significance of invasion of paralingual and sublingual spaces in relation to the pathological grade of these tumors, and its predictive value in pathological nodal involvement were analyzed...
April 2017: Indian Journal of Cancer
Dong Hoon Suh, Miseon Kim, Kyung Hun Lee, Keun Yong Eom, Maj Kamille Kjeldsen, Mansoor Raza Mirza, Jae Weon Kim
In 2017, 10 topics were selected as major clinical research advances in gynecologic oncology. For cervical cancer, efficacy and safety analysis results of a 9-valent human papillomavirus (HPV) vaccine and long-term impact of reduced dose of quadrivalent vaccine were updated. Brief introduction of KEYNOTE trials of pembrolizumab, a monoclonal antibody that blocks the interaction between programmed death (PD)-1 and its ligands, PD-L1 and PD-L2, followed. Tailored surveillance programs for gynecologic cancer related with Lynch syndrome and update on sentinel lymph node mapping were reviewed for uterine corpus cancer...
March 2018: Journal of Gynecologic Oncology
Chaninya Wongwarangkana, Nasamon Wanlapakorn, Jira Chansaenroj, Yong Poovorawan
Cervical cancer is one of the leading causes of death in women worldwide, particularly in developing countries. Human papillomavirus has been reported as one of the key etiologic factors in cervical carcinoma. Likewise, epigenetic aberrations have ability to regulate cancer pathogenesis and progression. Recent research suggested that methylation has been detected already at precancerous stages, which methylation markers may have significant value in cervical cancer screening. The retinoic acid receptor beta ( RAR β) gene, a potential tumor suppressor gene, is usually expressed in normal epithelial tissue...
February 12, 2018: World Journal of Virology
Amine Bazine, Hanae O Zniber, Meriem Ghaouti, Aziz Bazine, Aziz Baydada, Hassan Sifat
Metastases to the kidney are a rare entity. Among solid tumors, it is known that lung and colorectal cancers can metastasize to the kidney. Renal metastases from cervical cancer are exceptional; only 12 cases were previously reported. We report a case of a right renal metastasis from a cervical squamous cell carcinoma, occurring in the context of a metastatic relapse two years after completing primary treatment.
December 13, 2017: Curēus
Jun Won Kim, Tae Hyung Kim, Jie-Hyun Kim, Ik Jae Lee
AIM: To evaluate toxicity and treatment outcome of high-dose radiotherapy (RT) for cervical esophageal cancer (CEC). METHODS: We reviewed a total of 62 consecutive patients who received definitive RT for stage I to III cervical esophageal cancer between 2001 and 2015. Patients who received < 45 Gy, treated for lesions below sternal notch, treated with palliative aim, treated with subsequent surgical resection, or diagnosed with synchronous hypopharyngeal cancer were excluded...
February 21, 2018: World Journal of Gastroenterology: WJG
Veena B Nair, V G Manasa, M S Sinto, K Jayasree, Francis V James, S Kannan
OBJECTIVES: Cervical cancer is the second most common cancer in women in developing countries, including India. Recently, microRNAs (miRNAs) are gaining importance in cancer biology because of their involvement in various cellular processes. The present study aimed to profile miRNA expression pattern in cervical cancer, identify their target genes, and understand their role in carcinogenesis. METHODS: Human papillomavirus (HPV) infection statuses in samples were assessed by heminested polymerase chain reaction followed by direct DNA sequencing...
March 2018: International Journal of Gynecological Cancer
Di Liu, Yi Zheng, Meng Wang, Yujiao Deng, Shuai Lin, Linghui Zhou, Pengtao Yang, Cong Dai, Peng Xu, Qian Hao, Dingli Song, Huafeng Kang, Zhijun Dai
Previous studies have showed the associations between various BRCA1-interacting protein 1 ( BRIP1 ) polymorphisms and cancer risk. But, these results were inconsistent. This meta-analysis based on 18 studies involving 13,716 cancer patients and 15,590 cancer-free controls is aimed at to evaluate the relationship between the four common SNPs of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk. The results showed a decreased risk of rs2048718 or rs4986764 for cervical cancer rather than breast cancer in the overall population ( P < 0...
February 16, 2018: Aging
Mónica Saccucci, Eduardo L Franco, Lili Ding, David I Bernstein, Darron Brown, Jessica A Kahn
BACKGROUND: We examined non-vaccine-type HPV prevalence in a community before and over the first eight years after vaccine introduction, to assess for 1) type replacement with any non-vaccine type HPV and 2) cross-protection with non-vaccine types genetically related to vaccine-type HPV. METHODS: Sexually experienced 13-26-year-old women were recruited for three cross-sectional studies from 2006-2014 (N=1180). Outcome variables were: 1) prevalence of ≥ 1 of 32 anogenital non-vaccine-type HPVs and 2) prevalence of ≥ 1 HPV type genetically related to HPV16 and HPV18...
October 4, 2017: Sexually Transmitted Diseases
Shinji Toyoda, Hiroshi Okada, Hideo Tsujino, Yoshinori Takeda, Atsushi Sugiura, Yoshio Itani, Tsunekazu Kita, Eiwa Ishida
The Integran microfibrillar collagen hemostatic matrix is one form of microfibrillar collagen hemostat. This form has a sheet-type structure and has explicitly been used in Japan. In gynecology, this sheet-type matrix has helped effect uterine surface hemostasis, especially in myomectomy and cervical conization. However, cytotechnologists and pathologists have overlooked the foreign materials used for conization in postoperative cervical cytology. We report two cases describing the characteristic cervical cytology findings when Integran was used in conization...
February 21, 2018: Diagnostic Cytopathology
Mariah A Aredes, Marcelly R Garcez, Gabriela V Chaves
AIM: Assess the influence of chemoradiotherapy on the nutritional status, functional capacity and quality of life (QoL), associating these indicators at baseline with toxicity and interruption of oncologic treatment in women with cervical cancer. METHODS: Prospective cohort study performed on 49 women diagnosed with cervical cancer, who underwent treatment between August 2015 and January 2016. For data collection, two appointments were conducted by the lead researcher: the first occurred the day before the first chemotherapy session (T0) and the other at the end of chemotherapy session (T1)...
February 21, 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
Chun-Wai Mai, Yew-Beng Kang, Vishna Devi Nadarajah, Ahmad Sazali Hamzah, Mallikarjuna Rao Pichika
In this study, a series of 20 structurally similar vanilloids (Vn) were tested for their antiproliferative effects against 12 human cancer cells: human breast (MCF-7 and MDA-MB-231), cervical (HeLa), ovarian (Caov-3), lung (A549), liver (HepG2), colorectal (HT-29 and HCT116), nasopharyngeal (CNE-1 and HK-1), and leukemic (K562 and CEM-SS) cancer cells. Among all the tested vanilloids, Vn16 (6-shogaol) exhibited the most potent cytotoxic effects against human colorectal cancer cells (HT-29). The apoptotic induction effects exhibited by Vn16 on HT-29 cells were confirmed using dual staining fluorescence microscopy and enzyme-linked immunosorbent assay...
February 21, 2018: Phytotherapy Research: PTR
Purnima Bhat, Anne-Sophie Bergot, Nigel Waterhouse, Ian Hector Frazer
Cervical cancer is a malignant transformation of keratinocytes initiated by the E7 oncoprotein of human papillomavirus (HPV). These tumors are characterized by keratinocyte hyperproliferation and are often infiltrated with activated CD8 T cells. HPV infection confers changes to gain immunological advantage to promote chronic infection, and these persist with malignant transformation. We investigated the relative importance of the many redundant mechanisms of cytotoxicity used by CD8 T cells to kill keratinocytes expressing HPV E7 oncoprotein using extended-duration time-lapse microscopy that allows examination of cell-to-cell interactions during killing...
January 19, 2018: Oncotarget
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