keyword
MENU ▼
Read by QxMD icon Read
search

Cervical cancer

keyword
https://www.readbyqxmd.com/read/29236322/microrna-383-suppresses-the-pi3k-akt-mtor-signaling-pathway-to-inhibit-development-of-cervical-cancer-via-down-regulating-parp2
#1
Peng Teng, Yan Jiao, Min Hao, Xin Tang
This study aims to evaluate the effect of the regulatory relationship between microRNA-383 (miR-383) and PARP2 in the cell migration and invasion in human with cervical cancer (CC) via the PI3K-AKT-MTOR signaling pathway. Cancerous tissues and corresponding paracancerous tissues were collected from 115 patients with CC. The positive expression rate of PARP2 was detected by immunohistochemistry. Hela cells with highest miR-383 expression were selected and assigned into the blank, negative control (NC), miR-383 mimic, miR-383 inhibitor, si-PARP2 and miR-383 inhibitor + si-PARP2 groups...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29235108/initial-results-of-population-based-cervical-cancer-screening-program-using-hpv-testing-in-one-million-turkish-women
#2
Murat Gultekin, Mujdegul Zayifoglu Karaca, Irem Kucukyildiz, Selin Dundar, Guledal Boztas, Hatice Semra Turan, Ezgi Hacikamiloglu, Kamil Murtuza, Bekir Keskinkilic, Irfan Sencan
OBJECTIVE: To evaluate the Turkey's nationwide HPV DNA screening program on the basis of first 1 million screened women. METHODS: Women over age 30 were invited for population based screening via HPV DNA and conventional cytology. Samples were collected by family physicians and the evaluations and reports had been performed in the National Central HPV laboratories. RESULTS: The acceptance rate for HPV based cervical cancer screening after first invitation was nearly 36...
December 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29234950/the-evolution-of-endometrial-carcinoma-classification-through-application-of-immunohistochemistry-and-molecular-diagnostics-past-present-and-future
#3
REVIEW
Emily A Goebel, August Vidal, Xavier Matias-Guiu, C Blake Gilks
Uterine cancer was first subclassified based on anatomic site, separating those tumours arising from the endometrium from cervical cancers. There was then further subclassification of endometrial cancers based on cell type, and this correlated with the Type I and Type II categories identified through the epidemiological studies of Bokhman, with endometrioid carcinoma corresponding (approximately) to Type I and serous carcinoma to Type II. These histotypes are not clearly separable in practice, however, with considerable interobserver variability in histotype diagnosis, especially for high-grade tumours...
December 12, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29234851/correction-to-fdg-uptake-in-cervical-lymph-nodes-in-children-without-head-and-neck-cancer
#4
Reza Vali, Alaa Bakkari, Eman Marie, Mahnaz Kousha, Martin Charron, Amer Shammas
The original version of this article unfortunately contained a mistake. Author name Alaa Bakkari was incorrect. The correct spelling is given above.
December 13, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29234710/polypoid-endometriosis-mimicking-invasive-cancer-in-an-obese-postmenopausal-tamoxifen-user
#5
William T Jaegle, Jason C Barnett, Bridget R Stralka, Nicole P Chappell
Background: Tamoxifen is a medication often used for the treatment and prevention of breast cancer. It is classically associated with several gynecological side effects to include a thickened endometrial stripe, increased uterine polyp formation, and an increased risk of uterine cancer. Rarely tamoxifen use has been associated with proliferation of endometriosis often severe enough to mimic a late-stage gynecologic malignancy. Case: A 62-year-old Gravida 0 postmenopausal female with a medical history of severe obesity, infertility, and preventative tamoxifen use presented for evaluation of gross hematuria...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29234709/repeating-platinum-bevacizumab-in-recurrent-or-progressive-cervical-cancer-yields-marginal-survival-benefits
#6
Abigail S Zamorano, Leping Wan, Matthew A Powell, L Stewart Massad
Our objective was to assess overall survival of cervical cancer patients following prior platinum/bevacizumab chemotherapy, comparing retreatment with platinum/bevacizumab with alternative therapies. A retrospective analysis was performed of women who received platinum/bevacizumab (PB) chemotherapy for cervical cancer at Washington University between July 1, 2005 and December 31, 2015. Wilcoxon rank-sum exact test and Fisher's exact test were used to compare the treatment groups, and Kaplan Meier curves were generated...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29234622/impact-of-serum-tsh-and-anti-thyroglobulin-antibody-levels-on-lymph-node-fine-needle-aspiration-thyroglobulin-measurements-in-differentiated-thyroid-cancer-patients
#7
Marta Amaro da Silveira Duval, André Borsatto Zanella, Ana Patrícia Cristo, Carlo Sasso Faccin, Marcia Silva Graudenz, Ana Luiza Maia
Background: Thyroglobulin measurements in the washout of fine needle aspiration (FNA-Tg) are an excellent tool to detect lymph node (LN) metastases of differentiated thyroid carcinoma (DTC). Nevertheless, how to define the best cutoffs and the influence of potential confounders are still being discussed. Objective: To evaluate the accuracy of FNA-Tg measurement to detect DTC metastases and the influence of thyroid status and anti-thyroglobulin antibodies (TgAb)...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29233573/re-irradiation-in-gynaecological-malignancies-a-review
#8
A H Sadozye
Re-irradiation in gynaecological malignancies has become an increasingly frequent consideration. This can be delivered in multiple settings, with the most common being a patient with a history of cervical cancer developing a new vaginal cancer or endometrial cancer with local recurrence after hysterectomy and adjuvant pelvic radiation. A systematic review of the literature has unearthed a handful of reports, most delivering brachytherapy, with a small number on both external beam radiotherapy and stereotactic ablative radiotherapy...
December 9, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29233120/prediction-of-5-year-overall-survival-in-cervical-cancer-patients-treated-with-radical-hysterectomy-using-computational-intelligence-methods
#9
Bogdan Obrzut, Maciej Kusy, Andrzej Semczuk, Marzanna Obrzut, Jacek Kluska
BACKGROUND: Computational intelligence methods, including non-linear classification algorithms, can be used in medical research and practice as a decision making tool. This study aimed to evaluate the usefulness of artificial intelligence models for 5-year overall survival prediction in patients with cervical cancer treated by radical hysterectomy. METHODS: The data set was collected from 102 patients with cervical cancer FIGO stage IA2-IIB, that underwent primary surgical treatment...
December 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29232805/value-of-imaging-study-in-predicting-pelvic-lymph-node-metastases-of-uterine-cervical-cancer
#10
Wonguen Jung, Kyung Ran Park, Kyung-Ja Lee, Kyubo Kim, Jihae Lee, Songmi Jeong, Yi-Jun Kim, Jiyoung Kim, Hai-Jeon Yoon, Byung-Chul Kang, Hae Soo Koo, Sun Hee Sung, Min-Sun Cho, Sanghui Park
Purpose: To evaluate the diagnostic accuracy of computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) in predicting pelvic lymph node (LN) metastases in patients with cervical cancer. Materials and Methods: From January 2009 to March 2015, 114 patients with FIGO stage IA1-IIB uterine cervical cancer who underwent hysterectomy with pelvic lymphadenectomy and took CT, MRI, and PET/CT before surgery were enrolled in this study...
December 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29232581/homo-and-heteroleptic-pt-ii-complexes-of-onn-donor-hydrazone-and-4-picoline-a-synthetic-structural-and-detailed-mechanistic-anticancer-investigation
#11
Faiz-Ur Rahman, Muhammad Zeeshan Bhatti, Amjad Ali, Hong-Quan Duong, Yao Zhang, Bo Yang, Satish Koppireddi, Yuejian Lin, Hui Wang, Zhan-Ting Li, Dan-Wei Zhang
Two series of homoleptic Pt(II)(hydrazone)Cl (C1a-C5a) and heteroleptic Pt(II)(hydrazone)(4-picoline). BF4 (C1b-C5b) complexes were prepared and characterized by 1H, 13C, 19F NMR and HR ESI-MS. Structure of C2b was confirmed by single crystal X-ray analysis. These complexes were studied for their in vitro anticancer activities in human multiple cancer cells including breast (MCF-7), liver (HepG2), lung (H460), colon (HCT116) and cervical (Hela) cancers. C1a-C5a and C1b-C5b showed considerable anticancer effect...
November 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29232166/revisiting-knowledge-attitudes-and-practice-kap-on-human-papillomavirus-hpv-vaccination-among-female-university-students-in-hong-kong
#12
Jonathan Tin Chi Leung, Law Chi-Kin
Despite cervical cancer can be preventable by HPV vaccination, little is known on its associated factors among young females in Hong Kong. This study aimed to investigate the present situation regarding the self-reported knowledge, attitudes and practice (KAP) of Human Papillomavirus (HPV) vaccination and to examine their associated factors among female university students in Hong Kong. 195 respondents were recruited to complete a self-administered questionnaire from two local universities through convenience sampling...
December 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29231992/hcfu-inhibits-cervical-cancer-cells-growth-and-metastasis-by-inactivating-wnt-%C3%AE-catenin-pathway
#13
Ping Liu, Shuying Ma, Hua Liu, Huazhen Han, Shanshan Wang
BACKGROUND: 1-hexylcarbamoyl-5-fluorouracil (HCFU), also known as carmofur, is an effective chemotherapeutic agent applied to several cancers. This study was aimed to explore the functional effects of HCFU on cervical cancer cells and tried to uncover its possible mechanism. METHODS: Two immortalized cervical cancer cell lines (HeLa and Caski) and primary cervical cancer cells prepared from two cervical cancer patients were used in this study. Cell viability, apoptosis, colony formation, migration, invasion, and the expressions of cell growth- and metastasis-associated factors were respectively assessed following 0-1 µg/mL of HCFU treatment for 0-48 h...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29229929/oestrogen-receptor-%C3%AE-binds-the-foxp3-promoter-and-modulates-regulatory-t-cell-function-in-human-cervical-cancer
#14
Sreenivas Adurthi, Mahesh M Kumar, H S Vinodkumar, Geetashree Mukherjee, H Krishnamurthy, K Kshitish Acharya, U D Bafna, Devi K Uma, B Abhishekh, Sudhir Krishna, A Parchure, Murali Alka, R S Jayshree
Oestrogen controls Foxp3 expression in regulatory T cells (Treg cells) via a mechanism thought to involve oestrogen receptor alpha (ERα), but the molecular basis and functional impact of ERα signalling in Treg cells remain unclear. We report that ERα ligand oestradiol (E2) is significantly increased in human cervical cancer (CxCa) tissues and tumour-infiltrating Treg cells (CD4+CD25hiCD127low), whereas blocking ERα with the antagonist ICI 182,780 abolishes FOXP3 expression and impairs the function of CxCa infiltrating Treg cells...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229603/lnmicc-promotes-nodal-metastasis-of-cervical-cancer-by-reprogramming-fatty-acid-metabolism
#15
Chunliang Shang, Wei Wang, Yuandong Liao, Yili Chen, Tianyu Liu, Qiqiao Du, Jiaming Huang, Yanchun Liang, Junxiu Liu, Yunhe Zhao, Luyan Guo, Zheng Hu, Shuzhong Yao
Cancer spread to lymph nodes (LN) predicts poor survival but underlying mechanisms remain little understood. In this study, we show that overexpression of the long non-coding RNA LNMICC associates with LN metastasis of primary cervical cancer, where it serves as an independent high-risk factor in patient survival. Functional investigations demonstrated that LNMICC promoted LN metastasis by reprogramming fatty acid metabolism, by recruiting the nuclear factor NPM1 to the promoter of the fatty acid binding protein FABP5...
December 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29228931/research-protocol-cisplatin-associated-ototoxicity-amongst-patients-receiving-cancer-chemotherapy-and-the-feasibility-of-an-audiological-monitoring-program
#16
J Paken, C D Govender, V Sewram
BACKGROUND: Cisplatin is an anti-cancer chemotherapy drug classified as an alkylating agent. It is used for the treatment of a variety of cancers such as cervical, breast, stomach, prostate, bladder and oesophageal, to name a few. However due to its expansive toxicity profile, patients receiving cisplatin can experience high frequency hearing loss, a side effect known as ototoxicity. The dearth of information on the extent and severity of cisplatin-associated ototoxicity in South Africa prevents the implementation of a context-specific audiological monitoring programme...
December 11, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29228737/reduced-m6a-mrna-methylation-is-correlated-with-the-progression-of-human-cervical-cancer
#17
Xiuli Wang, Zenghui Li, Beihua Kong, Chen Song, Jianglin Cong, Jianqing Hou, Shaoguang Wang
The m6A mRNA methylation involves in mRNA splicing, degradation and translation. Recent studies have revealed that reduced m6A mRNA methylation might promote cancer development. However, the role of m6A mRNA methylation in cervical cancer development remains unknown. Therefore, we investigated the role of m6A methylation in cervical cancer in the current study. We first evaluated the m6A mRNA methylation level in 286 pairs of cervical cancer samples and their adjacent normal tissues by dot blot assay. Then the role of m6A on patient survival rates and cervical cancer progression were assessed...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228668/tsc-22-inhibits-csf-1r-function-and-induces-apoptosis-in-cervical-cancer
#18
Min-Ji Cho, Ji-Yeon Lee, Min-Gwan Shin, Hyun-Ji Kim, Yu-Joung Choi, Seung Bae Rho, Boh-Ram Kim, Ik Soon Jang, Seung-Hoon Lee
Colony stimulating factor 1 receptor (CSF-1R) regulates the monocyte/macrophage system, which is an essential component of cancer development. Therefore, CSF-1R might be an effective target for anti-cancer therapy. The overexpression of transforming growth factor (TGF)-β stimulated clone-22 (TSC-22) inhibits cancer cell proliferation and induces apoptosis, and TSC-22 is emerging as a key factor in tumorigenesis. In this study, we discovered CSF-1R as a new interacting partner of TSC-22 and identified its elevated expression in cervical cancer cells...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228665/risk-factors-for-human-papillomavirus-infection-prevalent-among-uyghur-women-from-xinjiang-china
#19
Guzhalinuer Abulizi, Hua Li, Patiman Mijiti, Tangnuer Abulimiti, Jing Cai, Jie Gao, Dandan Meng, Reyihanguli Abula, Tunishahan Abudereyimu, Anarguli Aizezi, You Lin Qiao
We investigated the incidence of HPV and risk factors for infection among rural Uyghur women in the Xinjiang province of northwestern China, where there is a high incidence of cervical cancer. We used the careHPV kit to test 6000 sexually active Uyghur women aged 21 to 60 years for HPV, and conducted a comprehensive questionnaire survey to identify relevant HPV infection factors. Our data show the HPV infection rate to be 8.42%, which is lower than 11.7% reported worldwide, despite the higher cervical cancer incidence...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228621/synergism-of-ursolic-acid-and-cisplatin-promotes-apoptosis-and-enhances-growth-inhibition-of-cervical-cancer-cells-via-suppressing-nf-%C3%AE%C2%BAb-p65
#20
Lan Li, Yu Hou, Jing Yu, Yulin Lu, Li Chang, Meiping Jiang, Xingrao Wu
Objective: This study was designed to investigate the effect of combination of ursolic acid (UA) with cisplatin (DDP) on cervical cancer cell proliferation and apoptosis. Methods: The mRNA and protein expressions of nuclear factor-kappa B (NF-κB) p65 in cervical cancer cells were examined using RT-PCR and western blot. MTT and colony formation assays were performed to examine the DDP toxicity and the proliferation ability of cervical cancer cells. Cell morphology was observed by means of Hoechst33258 and transmission electron microscopy (TEM)...
November 14, 2017: Oncotarget
keyword
keyword
2350
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"