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Keywords Hyperthermic intraperitoneal c...

Hyperthermic intraperitoneal chemotherapy

https://read.qxmd.com/read/38373815/long-term-recurrence-free-survival-following-pancreatic-surgery-with-hipec-treatment-for-locally-advanced-pancreatic-adenocarcinoma
#21
JOURNAL ARTICLE
Valerie Zimmermann, Leonie Frauenfeld, Markus W Löffler, André L Mihaljevic, Can Yurttas
More than 5 years previous to this report, a female patient in her 60s underwent oncological left-sided pancreatic resection and adrenalectomy including splenectomy for locally advanced pancreatic adenocarcinoma (PDAC), recommended by a multidisciplinary tumour board (MDT). Additionally, she was treated with gemcitabine-containing hyperthermic intraperitoneal chemotherapy (HIPEC) for 60 minutes in the framework of a clinical trial (PanHIPEC), aiming to determine the safety and feasibility (not efficacy) of this approach...
February 19, 2024: BMJ Case Reports
https://read.qxmd.com/read/38369417/outcomes-following-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec-for-peritoneal-malignancies-10%C3%A2-%C3%A2-year-experience
#22
JOURNAL ARTICLE
Isabella Graham, Anna Boston, Richard Hayward, Richard Berri
INTRODUCTION: The treatment of peritoneal malignancies has evolved and select patients can undergo effective surgical therapies. Access to innovative oncology procedures can be improved if programs are developed within and outside of academic cancer centers. We report the creation of a high volume, comprehensive peritoneal malignancy program developed in a community center. METHODS: A retrospective single-site study was conducted using registry data comprising all patients who underwent Cytoreductive Surgery (CRS) and Heated Intraperitoneal Chemotherapy (HIPEC) between October 2011-December 2021...
February 6, 2024: American Journal of Surgery
https://read.qxmd.com/read/38367177/short-term-safety-evaluation-of-albumin-bound-paclitaxel-in-intraoperative-and-postoperative-hyperthermic-intraperitoneal-chemotherapy-for-gastric-cancer
#23
JOURNAL ARTICLE
Jingxiang Zhou, Xiaopeng Cai, Zhao Lu, Bin Xiong, Chunwei Peng
PURPOSE: To evaluate the short-term safety of albumin-bound paclitaxel in hyperthermic intraperitoneal chemotherapy (HIPEC) during and after gastric cancer (GC) surgery. METHODS: A retrospective analysis of clinical data was conducted for GC surgery patients at Zhongnan Hospital of Wuhan University, from January 2020 to September 2022. The study group (n = 120) received HIPEC and the control group (n = 268) did not receive albumin-bound paclitaxel...
February 17, 2024: Journal of Gastrointestinal Cancer
https://read.qxmd.com/read/38353796/aso-visual-abstract-normal-cea-levels-after-neoadjuvant-chemotherapy-and-cytoreduction-with-hyperthermic-intraperitoneal-chemoperfusion-predict-improved-survival-from-colorectal-peritoneal-metastases
#24
JOURNAL ARTICLE
Michael M Wach, Geoffrey Nunns, Ahmed Hamed, Joshua Derby, Mark Jelinek, Curtis Tatsuoka, Matthew P Holtzman, Amer H Zureikat, David L Bartlett, Steven A Ahrendt, James F Pingpank, M Haroon A Choudry, Melanie Ongchin
No abstract text is available yet for this article.
February 14, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38350654/impacts-of-hyperthermic-chemotherapeutic-agent-on-cytotoxicity-chemoresistance-related-proteins-and-pd-l1-expression-in-human-gastric-cancer-cells
#25
JOURNAL ARTICLE
Bor-Chyuan Su, Guan-Yu Chen, Chun-Ming Yang, Wei-Ting Chuang, Meng-Chieh Lin, Pei-Ling Hsu, Chu-Wan Lee, Chih-Cheng Cheng, Shih-Ying Wu, Bo-Syong Pan, Hsin-Hsien Yu
Objective: Gastric cancer with peritoneal metastasis is considered to be final stage gastric cancer. One current treatment approach for this condition is combined cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). However, the therapeutic mechanisms of HIPEC remain largely undescribed. Method: In order to assess the cellular effects of HIPEC in vitro , we treated AGS human gastric adenocarcinoma cells with or without 5-fluorouracil (5-Fu) at 37 °C or at 43 °C (hyperthermic temperature) for 1 h followed by incubation at 37 °C for 23 h...
2024: International Journal of Hyperthermia
https://read.qxmd.com/read/38342495/risk-factors-of-chronic-kidney-disease-in-cisplatin-based-hyperthermia-intraperitoneal-chemotherapy
#26
JOURNAL ARTICLE
Chih-Chung Cheng, Hung-Chieh Yeh, Pei-Wen Su, Chien-Lin Ho, Sheng-Chi Chang
PURPOSE: Cisplatin is commonly prescribed in hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal malignancy. Acute kidney injury (AKI) is regarded as a common complication after HIPEC combined with cytoreductive surgery (CRS). However, post-HIPEC chronic kidney disease (CKD) is scarce and less investigated. This study aims to investigate the incidence of CKD following cisplatin-based HIPEC and to analyse the associated risk factors. MATERIALS AND METHODS: From January 2016 to August 2021, a total of 55 patients treated with CRS and cisplatin-based HIPEC for peritoneal carcinomatosis were categorized retrospectively into groups, with and without CKD...
2024: International Journal of Hyperthermia
https://read.qxmd.com/read/38341381/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-to-treat-pseudomyxoma-peritonei-of-ovarian-origin-a-retrospective-french-renape-group-study
#27
JOURNAL ARTICLE
Alexis Trecourt, Naoual Bakrin, Olivier Glehen, Witold Gertych, Laurent Villeneuve, Sylvie Isaac, Nazim Benzerdjeb, Juliette Fontaine, Catherine Genestie, Peggy Dartigues, Agnès Leroux, François Quenet, Frederic Marchal, Cecile Odin, Lakhdar Khellaf, Magali Svrcek, Sixte Thierry, Marilyn Augros, Alhadeedi Omar, Mojgan Devouassoux-Shisheboran, Vahan Kepenekian
BACKGROUND: Ovarian pseudomyxoma peritonei (OPMP) are rare, without well-defined therapeutic guidelines. We aimed to evaluate cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) to treat OPMP. METHODS: Patients from the French National Network for Rare Peritoneal Tumors (RENAPE) database with proven OPMP treated by CRS/HIPEC and with histologically normal appendix and digestive endoscopy were retrospectively included. Clinical and follow-up data were collected...
February 10, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38340494/appendiceal-adenocarcinoma-diagnosed-after-acute-perforated-appendicitis-potential-contribution-of-hipec
#28
JOURNAL ARTICLE
Elsa Leiritz, Jérémy Rezai, Mathilde Wagner, Armelle Bardier, Amu Therwath, Marc Pocard
INTRODUCTION: Treatment of peritoneal metastasis from appendicular adenocarcinoma consists of cyto-reductive surgery (CRS) and Hyperthermic IntraPEritoneal Chemotherapy (HIPEC). In case of acute appendicular syndrome (AAS) the tumor is likely to be perforated. In that case, there is no treatment recommendation. We propose CRS and HIPEC. MATERIALS AND METHOD: We listed 21 consecutive patients who were addressed for discovery of appendiceal adenocarcinoma. The emergency surgery was performed in a primary-care hospital...
January 19, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38339382/recurrence-and-survival-following-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-synchronous-and-metachronous-peritoneal-metastases-of-colorectal-origin
#29
JOURNAL ARTICLE
Mette Fugleberg Nielsen, Sissel Ravn, Mette Møller Sørensen, Jonas Amstrup Funder, Lene Hjerrild Iversen
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has improved the 5-year survival for colorectal cancer (CRC) patients with peritoneal metastases (PM). Little is known about recurrence patterns and recurrence rates between synchronous (S) and metachronous (M) PM following CRS+HIPEC. We aimed to describe the recurrence patterns, overall survival (OS) and disease-free survival (DFS) in S-PM and M-PM patients after complete CRS+HIPEC. From June 2006 to December 2020, a prospective cohort study included 310 CRC patients, where 181 patients had S-PM (58...
February 1, 2024: Cancers
https://read.qxmd.com/read/38337462/prophylactic-hyperthermic-intraperitoneal-chemotherapy-for-patients-at-high-risk-of-developing-gallbladder-cancer-peritoneal-metastases-case-report-and-rationale-for-a-prospective-clinical-trial
#30
REVIEW
Alexander E Crum, Michael Sestito, Mary Garland-Kledzik, Brian A Boone
Gallbladder cancer is a devastating disease with a 5-year survival of only 18%. The majority of gallbladder cancers are discovered incidentally in patients undergoing cholecystectomy. During non-oncologic laparoscopic cholecystectomy for gallbladder disease, gallbladder perforation occurs in 29% of cases and spillage of gallstones occurs in 9% of cases. Patients with gallbladder cancer frequently develop peritoneal recurrence, particularly after intra-operative bile spillage during cholecystectomy for incidental gallbladder cancer...
January 29, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38336936/aso-visual-abstract-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-to-treat-pseudomyxoma-peritonei-of-ovarian-origin-a-retrospective-french-renape-group-study
#31
JOURNAL ARTICLE
Alexis Trecourt, Naoual Bakrin, Olivier Glehen, Witold Gertych, Laurent Villeneuve, Sylvie Isaac, Nazim Benzerdjeb, Juliette Fontaine, Catherine Genestie, Peggy Dartigues, Agnès Leroux, François Quenet, Frederic Marchal, Cecile Odin, Lakhdar Khellaf, Magali Svrcek, Sixte Thierry, Marilyn Augros, Alhadeedi Omar, Mojgan Devouassoux-Shisheboran, Vahan Kepenekian
No abstract text is available yet for this article.
February 9, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38331695/-contribution-of-intraperitoneal-chemotherapy-in-the-treatment-of-colorectal-peritoneal-carcinoma-hipec-pipac-state-of-the-art-and-future-directions
#32
REVIEW
François Quénet, Sébastien Carrère, Olivia Sgarbura
After more than a decade of good results using the combination of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of peritoneal carcinosis of colorectal origin, the PRODIGE7 study, which specifically evaluated the role of HIPEC, failed to show any superiority in terms of overall and disease-free survival for the CRS+HIPEC combination compared with CRS alone. This study constituted a radical change in the knowledge and therapeutic attitudes observed to date...
February 7, 2024: Bulletin du Cancer
https://read.qxmd.com/read/38330272/building-an-efficient-peritoneal-surface-malignancies-program-despite-the-lower-middle-income-barriers-ukraine-experience
#33
JOURNAL ARTICLE
Viacheslav Kopetskyi, Marta Antoniv, Roman Yarema, Viacheslav Maksymovskyi, Valeriia Chetverikova-Ovchinnik, Vitalii Kryzhevskyi, Nataliya Volodko, Vadim Gushchin, Andrei Nikiforchin
PURPOSE: Cytoreductive surgery/hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) programs are often limited to centers in developed countries because of extensive requirements. We aimed to analyze efficacy and challenges of CRS/HIPEC centers in lower-middle-income settings in the Ukraine example. METHODS: A multicenter descriptive study was conducted using data sets (2008-2022) from Kyiv, Lviv, and Odesa centers. Patients with appendiceal neoplasm (AN); colorectal cancer (CRC); malignant peritoneal mesothelioma (MPM); and epithelial ovarian, fallopian tube, and primary peritoneal cancer (EOC) treated with CRS ± HIPEC were included...
February 2024: JCO global oncology
https://read.qxmd.com/read/38322605/role-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-the-management-of-colorectal-peritoneal-metastases
#34
REVIEW
Rupen Shah, Alexandra Gangi
Peritoneal metastases from colon cancer are a particularly challenging disease process given the limited response to systemic chemotherapy. In patients with isolated peritoneal metastases, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy offers a potential treatment option to these patients with limited peritoneal metastases as long as a complete cytoreduction is achieved. Decision about a patient's candidacy for this treatment modality should be undertaken by a multidisciplinary group at expert centers...
March 2024: Clinics in Colon and Rectal Surgery
https://read.qxmd.com/read/38322053/perforated-gastric-cancer-a-case-report-and-literature-review
#35
Kai Wang, Aye Thida, Gyuhee Seong, Edwin Chiu
Gastric cancer perforation is a rare but life-threatening complication of gastric cancer. We present the case of a 53-year-old male with acquired immune deficiency syndrome (AIDS) who presented to the emergency department with severe abdominal pain, was found to have an acute abdomen, and was eventually diagnosed with gastric perforation due to metastatic gastric cancer. This case highlights the challenges in diagnosing and managing perforated gastric cancer and discusses the surgical management options, including the use of laparoscopic techniques and the role of chemotherapy, particularly hyperthermic intraperitoneal chemotherapy (HIPEC)...
January 2024: Curēus
https://read.qxmd.com/read/38318560/biphasic-peritoneal-mesothelioma-is-a-rare-tumor-and-a-diagnostic-challenge-a-case-report
#36
Eihab A Subahi, Abdalla Fadul, Abdelaziz Mohamed, Ahmed Alsayed, Elrazi A Ali, Sagda Sayed, Salma Mustafa, Bara Wazwaz, Mohamed H Fadul
Malignant peritoneal mesothelioma (MPM) is a rare subtype of mesothelioma. There are three main histological subtypes of mesothelioma: epithelioid, sarcomatoid, and biphasic (mixed). Risk factors include asbestos exposure, previous radiation, and some germline mutations. Treatment includes surgical resection of amenable tumors or cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. We present a 34-year-old male who presented with weight loss, night sweats, and pleuritic chest pain and was found to have ascites with peritoneal nodularity on abdominal imaging...
January 2024: Curēus
https://read.qxmd.com/read/38313386/amplifying-curcumin-s-antitumor-potential-a-heat-driven-approach-for-colorectal-cancer-treatment
#37
JOURNAL ARTICLE
Janviere Kabagwira, Ryan N Fuller, Paul A Vallejos, Chase S Sugiono, Vola-Masoandro Andrianarijaona, Jazmine Brianna Chism, Michael P O'Leary, David Caba Molina, William Langridge, Maheswari Senthil, Nathan R Wall
INTRODUCTION: Peritoneal metastases from colorectal cancer (CRC) present a significant clinical challenge with poor prognosis, often unresponsive to systemic chemotherapy. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment approach for select patients. The use of curcumin, a natural compound with antitumor properties, in HIPEC is of interest due to its lower side effects compared to conventional drugs and potential for increased efficacy through direct delivery to the peritoneal cavity...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38310181/preoperative-ca-19-9-predicts-disease-progression-in-colorectal-peritoneal-metastases-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-an-analysis-from-the-us-hipec-collaborative
#38
JOURNAL ARTICLE
Nadege T Fackche, Ryan K Schmocker, Richard Nudotor, Boateng Kubi, Jordan M Cloyd, Travis E Grotz, Keith F Fournier, Sean P Dineen, Jula Veerapong, Joel M Baumgartner, Callisia N Clarke, Sameer H Patel, Gregory C Wilson, Laura A Lambert, Courtney Pokrzywa, Daniel E Abbott, Byrne Lee, Charles A Staley, Mohammad Y Zaidi, Fabian M Johnston, Jonathan B Greer
INTRODUCTION: Patients with colorectal peritoneal metastases (CRPM) are increasingly treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). Unfortunately, data identifying preoperative risk factors for poor oncologic outcomes after this procedure are limited. We aimed to determine the prognostic value of preoperative CEA, CA 125, and CA 19-9 on disease progression after CRS/HIPEC. METHODS: Patients with CRPM treated with curative intent CRS/HIPEC from 12 participating sites in the United States from 2000 to 2017 were identified...
February 3, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38307555/surgical-treatment-and-outcome-of-ovarian-cancer-patients-with-liver-metastases-experience-of-a-tertiary-hepatic-and-peritoneal-surface-malignancy-center
#39
JOURNAL ARTICLE
Miklos Acs, Zoltan Herold, Lea Neumann, Przemyslaw Slowik, Katja Evert, Simon Gurok, Ivan Panczel, Andras Jozsef Barna, Magdolna Dank, Attila Marcell Szasz, Matthias Hornung, Hans Jürgen Schlitt, Jens M Werner
BACKGROUND/AIM: The aim of this study was to describe and evaluate the patterns, perioperative outcomes, and survival rates of patients subjected to hepatic resections for ovarian-derived liver metastasis as part of cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC). Furthermore, we investigated two subgroups of tumor patterns: hematogenous liver metastasis and infiltrative liver metastatic spread. PATIENTS AND METHODS: A retrospective study was conducted...
February 2024: Anticancer Research
https://read.qxmd.com/read/38303256/-pancreatic-acinar-cell-carcinoma-with-peritoneal-recurrence-treated-with-peritonectomy-and-intraoperative-hyperthermic-intraperitoneal-chemotherapy-a-case-report
#40
JOURNAL ARTICLE
Yutaka Yonemura, Haruaki Ishibashi, Takuji Fujita, Yang Liu, Satoshi Wakama, Syouzou Sako, Toshiyuki Kitai, Kanji Katayama, Yasuyuki Kamada, Keizou Taniguchi, Daisuke Fujimoto, Jun Kajiwara, R M Hoffman
A 31-year-old man with a big epigastric mass from pancreas body was completely removed by distal pancreatectomy and segmental gastrectomy. Two years after oral administration of S-1 for 4 courses, peritoneal dissemination on the right subdiaphragmatic space was detected. Laparotomy revealed white colored round nodules were found scattered on the peritoneal surface, and the peritoneal cancer index(PCI)was 18. To achieve complete resection of peritoneal nodules, peritonectomy was performed. After complete removal of macroscopic peritoneal metastasis(PM), intraoperative hyperthermic intraoperative peritoneal chemotherapy using 1 gr of gemcitabine and 60 mg of docetaxel was performed for 40 min with thermal dose of 41...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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