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Hyperthermic intraperitoneal chemotherapy

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https://www.readbyqxmd.com/read/29782364/the-utility-of-diagnostic-laparoscopy-in-patients-being-evaluated-for-cytoreductive-surgery-and-hyperthermic-peritoneal-chemotherapy
#1
Raquel Bravo, Mehnareh D Jafari, Alessio Pigazzi
BACKGROUND: To assess the role of diagnostic laparoscopy (DL) to evaluate candidates for optimal cytoreduction surgery of peritoneal carcinomatosis (PC) combined with hyperthermic intraperitoneal chemotherapy in a consecutive series. METHODS: The characteristics of 31 patients undergoing DL between August 2012 and October 2016 for a diagnosis of PC secondary to digestive neoplasms were retrospectively reviewed. RESULTS: Laparoscopic evaluation was successful and well-tolerated in 100% patients (N=31)...
May 18, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29774943/-progress-in-prophylatic-hyperthermic-intraperitoneal-chemotherapy-for-advanced-gastric-carcinoma
#2
Xinhua Chen, Jun Luo, Hao Liu, Yuehong Chen, Yanfeng Hu, Tuanjie Li, Tian Lin, Yu Zhu, Mingli Zhao, Hao Chen, Guoxin Li, Jiang Yu
Advanced gastric cancer (AGC) has a high recurrence rate (especially peritoneal relapse) and a poor prognosis. Systematic chemotherapy or targeted therapy have not been able to significantly reduce the major cause of an unfavorable prognosis, namely the high peritoneal AGC recurrence rate post-surgery. Further studies concerning the application of hyperthermic intraperitoneal chemotherapy (HIPEC) post curative surgery for AGC patients, namely the prophylactic HIPEC (P-HIPEC), have involved a prophylactic approach to prevent peritoneal relapse following curative gastrectomy in high-risk patients...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29771808/predicting-survival-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-appendix-adenocarcinoma
#3
Omer Aziz, Ihab Jaradat, Bipasha Chakrabarty, Chelliah R Selvasekar, Paul E Fulford, Mark P Saunders, Andrew G Renehan, Malcolm S Wilson, Sarah T O'Dwyer
BACKGROUND: Appendix adenocarcinomas are rare tumors with propensity for peritoneal metastasis. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is an established treatment with curative intent, but, to date, studies reporting survival have been heterogeneous with regard to their patient groups (including other tumor types), interventions (not all patients receiving intraperitoneal chemotherapy), and follow-up (varying surveillance protocols). OBJECTIVE: The aim of this study is to quantify the impact of this intervention on survival in a homogeneous group of patients with appendix adenocarcinoma receiving standardized treatment and follow-up, and to determine the impact of prognostic indicators on survival...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29770622/hyperthermic-intraperitoneal-chemotherapy-in-advanced-ovarian-cancer
#4
Tao Wu, Xi Xia Zhao, Guo Qing Wang
No abstract text is available yet for this article.
March 9, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29764445/current-practices-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-the-treatment-of-peritoneal-surface-malignancies-an-international-survey-of-oncologic-surgeons
#5
Heon Jong Yoo, Jenny J Hong, Young Bok Ko, Mina Lee, Youjin Kim, Hye Young Han, Yong Jung Song, Myong Cheol Lim, Sang-Yoon Park
BACKGROUND: The goal of the study was to investigate the current clinical practices among oncologic surgeons regarding cytoreductive surgery (CRS) with intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: From September to October 2016, an online questionnaire surveyed the oncologic surgeons by email. The questionnaire included 20 multiple-choice questions of the following: eligibility for the CRS with HIPEC procedure, perioperative staging and surgery skill, assessment of residual tumors, and method used for intraperitoneal HIPEC...
May 15, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29761503/evaluation-of-the-peritoneal-surface-disease-severity-score-psdss-in-ovarian-cancer-patients-undergoing-cytoreductive-surgery-and-hipec-two-pathogenetic-types-based-study
#6
Roman Yarema, Taras Fetsych, Natalya Volodko, Myron Оhorchak, Orest Petronchak, Roman Huley, Yuriy Mylyan, Olivier Glehen
BACKGROUND AND OBJECTIVES: Clinical experience suggests that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) play an important role in the management of ovarian cancer. In order to improve patient selection, the peritoneal surface disease severity score (PSDSS) was previously introduced for use in colorectal cancer patients. However, almost no data exist regarding the utility of the PSDSS index in ovarian cancer patients. METHODS: A retrospective study of the effectiveness of CRS and HIPEC was carried out in 59 patients with ovarian cancer...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29755773/early-experience-with-cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy-at-a-newly-developed-center-for-peritoneal-malignancy
#7
Whitney L Guerrero, Gitonga Munene, Paxton V Dickson, Dina Darby, Andrew M Davidoff, Michael G Martin, Evan S Glazer, David Shibata, Jeremiah L Deneve
Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has improved outcomes for patients with peritoneal carcinomatosis (PC). We present our experience from a newly developed peritoneal surface malignancy program. Methods: An IRB approved retrospective review was performed for the first 50 patients treated with CRS/HIPEC with clinicopathologic data described. Results: Patients treated with CRS/HIPEC were Caucasian (64%), female (66%) with a median age of 53 years (range, 11-73 years)...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755762/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-ovarian-and-gastrointestinal-peritoneal-carcinomatosis-results-from-a-7-year-experience
#8
Giulia Montori, Federico Coccolini, Paola Fugazzola, Marco Ceresoli, Matteo Tomasoni, Carolina Rubicondo, Stefano Raimondo, Domenico Pinelli, Michele Colledan, Luigi Frigerio, Luca Ansaloni
Background: An increasing promising evidence and increasing long-term oncologic outcomes support the use of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as locoregional treatment for peritoneal carcinosis (PC) especially from ovarian and gastrointestinal tumors, but also for others cancers. Methods: A prospective monocentric study was performed in Papa Giovanni XXIII Hospital, Bergamo (Italy). Patients and tumor characteristics were analyzed...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29752854/perioperative-factors-associated-with-persistent-opioid-use-after-extensive-abdominal-surgery-in-children-and-adolescents-a-retrospective-cohort-study
#9
Pascal Owusu-Agyemang, Juan P Cata, Antoinette Van Meter, Ravish Kapoor, Acsa M Zavala, Uduak U Williams, January Tsai, Elizabeth Rebello, Lei Feng, Andrea Hayes-Jordan
BACKGROUND: In adults, preoperative opioid use and higher perioperative opioid consumption have been associated with higher odds of persistent opioid use after surgery. There are limited data on the prevalence and factors associated with persistent opioid use after major oncologic surgery in children. AIMS: In this study, we sought to determine the prevalence and factors associated with the development of persistent opioid use in a group of children and adolescents who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy...
May 12, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29745097/quality-of-life-after-cytoreductive-surgery-and-hipec-a-single-centre-prospective-study
#10
Nikolaos Kopanakis, Eleftherios-Orestis Argyriou, Dimitra Vassiliadou, Christina Sidera, Maria Chionis, John Kyriazanos, Elias Efstathiou, John Spiliotis
PURPOSE: Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has become a crucial method in the management of peritoneal metastasis. This study evaluated the Quality of Life (QoL) post CRS plus HIPEC. METHODS: 80/95 patients underwent CRS plus HIPEC at the Metaxa Cancer Hospital, Piraeus, Greece from 06/2011 to 06/2015 and completed the colorectal version of the Functional Assessment of Cancer Therapy questionnaire (FACTC, version 4) at 1 week pre-operatively and at 1, 3, 6, 12, 18, 24 months post-operatively...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29745096/cytoreduction-and-hipec-for-peritoneal-carcinomatosis-of-pancreatic-cancer
#11
Antonios-Apostolos Tentes, Nicolaos Pallas, Christina Karamveri, Dimitrios Kyziridis, Christos Hristakis
PURPOSE: Peritoneal carcinomatosis of pancreatic cancer is generally considered for palliative treatment. The purpose of this study was to report the outcome of cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) in patients with pancreatic cancer and peritoneal carcinomatosis. METHODS: Patients with documented resectable peritoneal carcinomatosis of pancreatic cancer underwent cytoreductive surgery in combination with HIPEC from 2008-2016 by the same surgical team...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29740664/-extension-of-recurrence-free-and-overall-survival-in-patients-with-ovarian-cancer-stage-iii-using-hyperthermic-intraperitoneal-chemotherapy-hipec
#12
Gerhard G Grabenbauer
No abstract text is available yet for this article.
May 8, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29732979/cold-physical-plasma-treated-buffered-saline-solution-as-effective-agent-against-pancreatic-cancer-cells
#13
Sander Bekeschus, Andre Kading, Tim Schroder, Kristian Wende, Christine Hackbarth, Kim Rouven Liedtke, Julia van der Linde, Thomas von Woedtke, Claus-Dieter Heidecke, Lars-Ivo Partecke
Cold physical plasma has been suggested as a new anticancer tool recently. However, direct use of plasma is limited to visible tumors and in some clinical situations not feasible. This includes repetitive treatment of peritoneal metastases which commonly occur in advanced gastrointestinal cancer and in pancreatic cancer in particular. In case of diffuse intraperitoneal metastatic spread Hyperthermic Intraperitoneal Intraoperative Chemotherapy (HIPEC) is used as therapeutic approach. Plasma treated solutions may combine their suspected systemic non-toxic characteristics with the anticancer effects of HIPEC...
May 7, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29730733/robotic-assisted-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-crs-hipec
#14
Emmanuel Gabriel, Enrique Elli, Sanjay Bagaria, Nabil Wasif, Travis Grotz, John Stauffer, Pashtoon M Kasi, Horacio Asbun
BACKGROUND: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is an appropriate treatment for select patients with peritoneal carcinomatosis. While most commonly performed through an open incision, the laparoscopic approach has been reported and offers short-term benefits. A robotic-assisted approach for carcinomatosis of gastrointestinal origin, however, has not yet been described. METHODS: We report our approach to robotic-assisted CRS-HIPEC for a patient with a perforated appendiceal mucocele...
May 5, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29721724/malignant-peritoneal-mesothelioma-national-practice-patterns-outcomes-and-predictors-of-survival
#15
Vivek Verma, Richard L Sleightholm, Chad G Rusthoven, Matthew Koshy, David J Sher, Surbhi Grover, Charles B Simone
PURPOSE: This study of a large, contemporary national database evaluated management patterns, outcomes, and prognostic factors of malignant peritoneal mesothelioma (MPM) in the USA. METHODS: The National Cancer Data Base was queried for newly diagnosed nonmetastatic MPM. Patients were divided into five cohorts: observation, chemotherapy alone, cytoreductive surgery (CRS) alone, CRS/chemo [referring to any non-hyperthermic intraperitoneal chemotherapy (HIPEC) chemotherapy], and CRS/HIPEC...
May 2, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29721013/changes-in-hepatic-blood-flow-and-liver-function-during-closed-abdominal-hyperthermic-intraperitoneal-chemotherapy-following-cytoreduction-surgery
#16
Stéphanie Dupont, Eduardo R C Schiffer, Marion J White, John R A Diaper, Marc-Joseph Licker, Philippe C Masouyé
Background: The increase in intra-abdominal pressure (IAP) during closed abdominal hyperthermic intraperitoneal chemotherapy (HIPEC) leads to major haemodynamic changes and potential organ dysfunction. We investigated these effects on hepatic blood flow (HBF) and liver function in patients undergoing HIPEC following cytoreductive surgery and fluid management guided by dynamic preload indices. Methods: In this prospective observational clinical study including 15 consecutive patients, we evaluated HBF by transesophageal echocardiography and liver function by determination of the indocyanine green plasma disappearance rate (ICG-PDR)...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29713875/impact-of-synchronous-liver-resection-on-the-perioperative-outcomes-of-patients-undergoing-crs-hipec
#17
Jordan M Cloyd, Sherif Abdel-Misih, John Hays, Mary E Dillhoff, Timothy M Pawlik, Carl Schmidt
BACKGROUND: While liver resection (LR) and cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) are commonly performed for hepatic and peritoneal metastases, respectively, the safety of synchronous LR and CRS-HIPEC has not been established. METHODS: The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) databases from 2005 to 2016 were used to identify patients who underwent CRS-HIPEC. Demographic, clinical, and perioperative outcomes were compared among patients who underwent CRS-HIPEC with and without synchronous LR...
April 30, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29708906/intra-operative-cutaneous-temperature-monitoring-with-zero-heat-flux-technique-3m-spoton-in-comparison-with-oesophageal-and-arterial-temperature-a-prospective-observational-study
#18
Matthieu Boisson, Anouk Alaux, Thomas Kerforne, Olivier Mimoz, Bertrand Debaene, Claire Dahyot-Fizelier, Denis Frasca
BACKGROUND: Continuous monitoring of core temperature is essential during major surgery as a way of improving patient safety. Oesophageal probes or specific arterial catheters are invasive methods used in this setting. A new noninvasive device based on zero-heat-flux (ZHF) technique (SpotOn) seems promising but has been poorly investigated during rapid core temperature changes (RCTC). OBJECTIVE: To assess the accuracy of a SpotOn sensor vs. an oesophageal probe or specific arterial catheter during a slow change in core temperature of less than 1 °C within 30 min and RCTC ≥ 1 °C within 30 min...
April 27, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29703622/multicystic-mesothelioma-operative-and-long-term-outcomes-with-cytoreductive-surgery-and-hyperthermic-intra-peritoneal-chemotherapy
#19
Eran Nizri, Dario Baratti, Marcello Guaglio, Snita Sinukumar, Antonello Cabras, Shigeki Kusamura, Marcello Deraco
BACKGROUND: Multicystic peritoneal mesothelioma (MCPM) is an extremely rare disease with 40-50% rate of recurrence after surgical debulking. Due to the recurrent nature of the disease, the option of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) was offered for this condition. In the present study we aimed to describe the outcomes of this strategy in a single center cohort. METHODS: We retrospectively reviewed a prospectively collected database of all patients with MCPM that underwent the combined procedure in our center...
March 14, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29699564/cirrhosis-is-not-a-contraindication-to-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-highly-selected-patients
#20
Anna Weiss, Erin P Ward, Joel M Baumgartner, Andrew M Lowy, Kaitlyn J Kelly
BACKGROUND: Patient selection for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is critically important to optimizing outcomes. There is currently no literature regarding the safety of CRS/HIPEC in patients with cirrhosis. The aim of this case series is to report the outcomes of three patients with well-compensated cirrhosis who underwent CRS/HIPEC. METHODS: Patients were identified from a prospectively maintained peritoneal surface malignancy database...
April 26, 2018: World Journal of Surgical Oncology
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