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JOURNAL ARTICLE
Givi Lengvenis, Julius Drachneris, Edvardas Žurauskas, Aleksandra Ekkert, Andrius Berūkštis, Marius Kurminas, Rokas Girčius, Kipras Mikelis, Andrej Afanasjev, Kristina Ryliškienė, Arvydas Laurinavičius, Algirdas Edvardas Tamošiūnas
BACKGROUND: Acute embolic ischemic stroke poses a significant healthcare challenge. Histological clot features' variability among patients with acute ischemic stroke treated by mechanical thrombectomy has potential implications for determining treatment and etiology. This study investigated the clot histological feature differences among patients who experienced cardioembolic stroke and embolic stroke of undetermined source with different left atrial appendage (LAA) morphologies. METHODS: We conducted a prospective observational study involving 79 patients with acute embolic ischemic stroke undergoing mechanical thrombectomy...
March 17, 2024: Journal of Clinical Medicine
#22
JOURNAL ARTICLE
Rónán O'Caoimh, Laura Morrison, Marion Hanley, Caoimhe McManus, Kate Donlon, Patricia Galvin
Stroke due to atrial fibrillation (AF) is more common in older adults. Frailty is associated with AF. As little is known about the impact of frailty on cardioembolic stroke, we examined its association with important healthcare outcomes including mortality and functional outcome in stroke with AF. Data were collected from patients presenting consecutively to a regional university hospital to assess pre-admission frailty using the Clinical Frailty Scale (CFS) and function with the Modified Rankin Scale (mRS)...
February 27, 2024: International Journal of Environmental Research and Public Health
#23
JOURNAL ARTICLE
Margaret Moores, Raed A Joundi, Nishita Singh, Andrew M Penn, Kristine Votova, Eric E Smith, Shelagh B Coutts
BACKGROUND: Magnetic resonance imaging infarct topography may assist with determining stroke etiology. The influence of diffusion-weighted imaging (DWI)-positive lesions on etiology determination in patients with transient ischemic attack or minor stroke is not well studied. METHODS AND RESULTS: We prospectively enrolled patients between 2010 and 2017 in 2 studies; participants with a final diagnosis of probable or definite transient ischemic attack or stroke were pooled for analysis...
March 27, 2024: Journal of the American Heart Association
#24
JOURNAL ARTICLE
Sook Joung Lee, Shimeng Liu, Haley Blackwill, Dana Stradling, Mohammad Shafie, Wengui Yu
BACKGROUND: Methamphetamine use has emerged as a major risk factor for cardiovascular and cerebrovascular disease in young adults. The aim of this study was to investigate a possible association of methamphetamine use with cardioembolic stroke. METHODS AND RESULTS: We performed a retrospective study of patients with acute ischemic stroke admitted at our medical center between 2019 and 2022. All patients were screened for methamphetamine use and cardiomyopathy, defined as left ventricular ejection fraction ≤45%...
March 27, 2024: Journal of the American Heart Association
#25
JOURNAL ARTICLE
Dongjuan Xu, Huan Zhou, Mengmeng Hu, Yilei Sheng, Hongfei Li, Lianyan Wei, Jing Xu, Zhuangzhuang Jiang, Xiaoli Shao, Zhenhua Xi, Songbin He, Min Lou, Shaofa Ke
OBJECTIVES: To investigate the safety of early antiplatelet therapy in non-cardioembolic mild stroke patients with thrombocytopenia. METHODS: Data of acute ischemic stroke patients with baseline National Institutes of Health Stroke scale (NIHSS) score ≤3 and a platelet count <100×109 /L were obtained from a multicenter register. Those who required anticoagulation or had other contraindications to antiplatelet therapy were excluded. Short-term safety outcomes were in-hospital bleeding events, while the long-term safety outcome was 1-year all-cause death...
March 25, 2024: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
#26
JOURNAL ARTICLE
Karoliina Aarnio, Nicolas Martinez-Majander, Elena Haapaniemi, Eeva Kokkola, Jenna Broman, Lauri Tulkki, Markku Kaste, Turgut Tatlisumak, Jukka Putaala
INTRODUCTION: Scarce data exist on the etiology of recurrent ischemic strokes (ISs) among young adults. We analyzed the etiology of first-ever and recurrent events and the differences between them. PATIENTS AND METHODS: Patients aged 15-49 years with a first-ever IS in 1994-2007 were included in the Helsinki Young Stroke Registry. In this retrospective cohort study, data on recurrent ISs were identified from Care Register for Health Care until the end of 2017 and Causes of Death Register and from patient records until the end of 2020...
March 25, 2024: European Stroke Journal
#27
JOURNAL ARTICLE
Fatemeh Koohi, Eric L Harshfield, Alexey Shatunov, Hugh S Markus
BACKGROUND: The importance of thromboembolism in the pathogenesis of lacunar stroke (LS), resulting from cerebral small vessel disease (cSVD), is debated, and although antiplatelets are widely used in secondary prevention after LS, there is limited trial evidence from well-subtyped patients to support this approach. We sought to evaluate whether altered anticoagulation plays a causal role in LS and cSVD using 2-sample Mendelian randomization. METHODS: From a recent genome-wide association study (n=81 190), we used 119 genetic variants associated with venous thrombosis at genome-wide significance ( P <5*10-8 ) and with a linkage disequilibrium r2 <0...
April 2024: Stroke; a Journal of Cerebral Circulation
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JOURNAL ARTICLE
Wei Sun, Yuan Wang, Cancan Li, Xuefan Yao, Xiao Wu, Aini He, Benke Zhao, Xiaoqin Huang, Haiqing Song
OBJECTIVE: Cross-sectional and cohort studies have found insufficient evidence of a causal relationship between sex hormone-binding globulin and ischemic stroke, only associations. Here, we performed a sex-stratified, bidirectional, two-sample Mendelian randomization analysis to evaluate whether a causal relationship exists between sex hormone-binding globulin and ischemic stroke. METHODS: Single-nucleotide polymorphisms associated with sex hormone-binding globulin and ischemic stroke were screened from genome-wide association studies summary data as instrumental variables to enable a bidirectional, two-sample Mendelian randomization study design...
March 22, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#29
Songnan Wen, Tasneem Z Naqvi
Atherosclerosis is the most common cause of heart disease and stroke. Plaque thickness ≥4 mm in the ascending aorta or aortic arch is strongly correlated with cerebral embolic events and ischemic stroke. However, despite imaging workup, the cause of embolic stroke remains unidentified in many patients. Transesophageal echocardiography (TEE) is the preferred echocardiographic method for the evaluation of cardiac source of emboli. 2D TEE imaging evaluates aortic root and aortic arch in a single plane or two planes with biplane imaging...
March 2024: Echocardiography
#30
JOURNAL ARTICLE
Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case-control study.
Xingyu Wang, Xin Liu, Martin J O'Donnell, Matthew McQueen, Allan Sniderman, Guillaume Pare, Graeme J Hankey, Sumathy Rangarajan, Siu Lim Chin, Purnima Rao-Melacini, John Ferguson, Denis Xavier, Hongye Zhang, Lisheng Liu, Prem Pais, Patricio Lopez-Jaramillo, Albertino Damasceno, Peter Langhorne, Annika Rosengren, Antonio L Dans, Ahmed Elsayed, Alvaro Avezum, Charles Mondo, Conor Judge, Hans-Christoph Diener, Danuta Ryglewicz, Anna Czlonkowska, Nana Pogosova, Christian Weimar, Romana Iqbal, Rafael Diaz, Khalid Yusoff, Afzalhussein Yusufali, Aytekin Oguz, Ernesto Penaherrera, Fernando Lanas, Okechukwu S Ogah, A Ogunniyi, Helle K Iversen, German Malaga, Zvonko Rumboldt, Shahram Oveisgharan, Fawaz Al Hussain, Yongchai Nilanont, Salim Yusuf
BACKGROUND: Smoking is a major risk factor for the global burden of stroke. We have previously reported a global population attributable risk (PAR) of stroke of 12.4% associated with current smoking. In this study we aimed to explore the association of current tobacco use with different types of tobacco exposure and environmental tobacco smoke (ETS) exposure on the risk of stroke and stroke subtypes, and by regions and country income levels. METHODS: The INTERSTROKE study is a case-control study of acute first stroke and was undertaken with 13,462 stroke cases and 13,488 controls recruited between January 11, 2007 and August 8, 2015 in 32 countries worldwide...
April 2024: EClinicalMedicine
#31
JOURNAL ARTICLE
N A Pizov, N S Baranova
OBJECTIVE: To evaluate the main modifiable risk factors for ischemic stroke (IS) and features of the course in atherothrombotic, cardioembolic, and lacunar subtypes of IS in men aged 18-50 years. MATERIAL AND METHODS: The study included 125 men (the mean age was 42.6±5.3 years) who were admitted to the Vascular department before the COVID-19 pandemic and survived for the first 30 days after IS. Information on patients' baseline characteristics, traditional vascular risk factors, and lifestyle risk factors was systematically collected...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#32
JOURNAL ARTICLE
Danial Habibi, Farshad Teymoori, Navid Ebrahimi, Sahand Tehrani Fateh, Leila Najd-Hassan-Bonab, Amir Hossein Saeidian, Alireza Soleymani Taloubaghi, Sara Asgarian, Farhad Hosseinpanah, Hakon Hakonarson, Fereidoun Azizi, Mehdi Hedayati, Maryam Sadat Daneshpour, Mahdi Akbarzadeh, Marjan Mansourian
BACKGROUND AND AIMS: The putative association between serum 25-hydroxyvitamin D concentration [25(OH)D] and the risk of cardioembolic stroke (CES) has been examined in observational studies, which indicate controversial findings. We performed Mendelian randomization (MR) analysis to determine the causal relationship of serum 25(OH)D with the risk of CES. METHODS AND RESULTS: The summary statistics dataset on the genetic variants related to 25(OH)D was used from the published GWAS of European descent participants in the UK Biobank, including 417,580 subjects, yielding 143 independent loci in 112 1-Mb regions...
February 28, 2024: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
#33
JOURNAL ARTICLE
Aaisha Ferkh, Kasun De Silva, Jennifer Pham, Luke Stefani, Karen Byth, Amy Clark, Siddharth J Trivedi, Sai Nagaratnam, Andrew Duggins, Eddy Kizana, Aravinda Thiagalingam, Liza Thomas
AIMS: Embolic Stroke of Undetermined Source (ESUS) results in significant morbidity. A left atrial (LA) myopathy is implicated in a proportion of these patients. We hypothesized that LA shape varies by cause of stroke (cardioembolic versus ESUS). METHODS AND RESULTS: 236 ischemic stroke, atrial fibrillation (AF) patients and controls were recruited prospectively. AF was classified as paroxysmal (PAF) or persistent AF (PersAF). Stroke patients comprised cardioembolic stroke (CE) secondary to AF and ESUS...
March 15, 2024: European Heart Journal Cardiovascular Imaging
#34
JOURNAL ARTICLE
Fedra Kuris, Sara Tartaglia, Roberto Sperotto, Laura Ceccarelli, Daniele Bagatto, Simone Lorenzut, Giovanni Merlino, Francesco Janes, Carolina Gentile, Roberto Marinig, Lorenzo Verriello, Mariarosaria Valente, Giada Pauletto
BACKGROUND AND PURPOSE: Isolated insular strokes (IIS) are a rare occurrence due to the frequent concomitant involvement of adjacent territories, supplied by the M2 segment of the middle cerebral artery (MCA), and clinical aspects are sometimes contradictory. We aimed to describe clinical and radiological characteristics of a pure IIS case series, focusing on its functional outcome and cardiac involvement. METHODS: We identified 15 isolated insular ischemic strokes from a pool of 563 ischemic strokes occurred between January 2020 and December 2021...
2024: Frontiers in Neurology
#35
JOURNAL ARTICLE
Maxwell Isaac, Senthil A Kumar, Gregory F Petroski, Alex Shinn, Ashir Mehra, Camilo R Gomez
OBJECTIVES: Current guidelines recommend transthoracic echocardiography (TTE) following an ischemic stroke as the primary technique to identify cardiac abnormalities associated with an increased risk of cerebral embolism. It is unclear whether cardiac magnetic resonance imaging (cMRI), a technique shown to provide increased imaging resolution, may also enhance the cardiac assessment of ischemic stroke patients. We compared cMRI with TTE in the evaluation of LA size and pump function in a cohort of 44 patients with ischemic stroke...
March 12, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#36
JOURNAL ARTICLE
Ahmet Hakan Ates, Ahmet Kivrak, Ugur Nadir Karakulak, Cem Coteli, Hikmet Yorgun, Mehmet Levent Sahiner, Ergun Barıs Kaya, Kudret Aytemir
BACKGROUND: The study explores left atrial appendage closure (LAAC) as a safe and effective alternative to anticoagulation for atrial fibrillation (AF) patients at high bleeding risk. Complications, such as cardioembolic events due to left atrial appendage thrombus (LAAT), highlight the need for alternative stroke prevention strategies. AIMS: This research assesses LAAC's safety and efficacy in patients with LAAT, aiming to offer valuable insights into its potential as a viable option for stroke prevention in such cases...
March 13, 2024: Pacing and Clinical Electrophysiology: PACE
#37
JOURNAL ARTICLE
Rosanna Rossi, Duaa Jabrah, Andrew Douglas, James Prendergast, Abhay Pandit, Michael Gilvarry, Ray McCarthy, Petra Redfors, Annika Nordanstig, Turgut Tatlisumak, Erik Ceder, Dennis Dunker, Jeanette Carlqvist, István Szikora, Georgios Tsivgoulis, Klearchos Psychogios, John Thornton, Alexandros Rentzos, Katarina Jood, Jesus Juega, Karen M Doyle
The need for biomarkers for acute ischemic stroke (AIS) to understand the mechanisms implicated in pathological clot formation is critical. The levels of the brain natriuretic peptides known as brain natriuretic peptide (BNP) and NT-proBNP have been shown to be increased in patients suffering from heart failure and other heart conditions. We measured their expression in AIS clots of cardioembolic (CE) and large artery atherosclerosis (LAA) etiology, evaluating their location inside the clots, aiming to uncover their possible role in thrombosis...
March 5, 2024: International Journal of Molecular Sciences
#38
RANDOMIZED CONTROLLED TRIAL
Mohamed G Zeinhom, Mohamed Fouad Elsayed Khalil, Islam Fathallah Mohamed Kamel, Ahmed Mohamed Kohail, Sherihan Rezk Ahmed, Ahmed Elbassiouny, Ashfaq Shuaib, Omar M Al-Nozha
Worldwide, stroke is a leading cause of long-term disability in adults. Alteplase is the only approved treatment for acute ischemic stroke (AIS) and results in an improvement in a third of treated patients. We evaluated the post-stroke unfavourable outcome predictors in alteplase-treated patients from Egypt and Saudi Arabia. We assessed the effect of different risk factors on AIS outcomes after alteplase in Egypt and Saudi Arabia. Our study included 592 AIS alteplase-treated patients. The relationship between risk factors, clinical presentation, and imaging features was evaluated to predict factors associated with poor outcomes...
March 12, 2024: Scientific Reports
#39
JOURNAL ARTICLE
Euihyun Sung, Wonjae Sung, Young-Jun Lee, So Yeong Jeong, Soo Jeong, Hyun Young Kim, Hyuk Sung Kwon, Seong-Ho Koh, Young Seo Kim
Vertebral artery dissection (VAD) is often associated with medullary infarction; however, an underlying cause may be underestimated. This study aimed to assess the diagnostic potential of hypointense signal lesions along the arterial pathways using susceptibility-weighted imaging (SWI) as a feasible indicator of VAD in medullary infarction. A retrospective analysis was conducted using clinical data, brain magnetic resonance imaging, and angiography records of 79 patients diagnosed with medullary infarction between January 2014 and December 2021...
March 4, 2024: Scientific Reports
#40
JOURNAL ARTICLE
Guangcai Shao, Xiang Li, Meiyue Da, Xiaochuan Huo, Shuheng Zhang
BACKGROUND AND PURPOSE: Studies on outcome comparison after endovascular treatment (EVT) for large vessel occlusion (LVO) between large artery atherosclerosis (LAA) and cardioembolism (CE) in the Asian population are scarce. We aimed to compare the baseline characteristics and clinical outcomes after EVT for anterior circulation LVO with LAA and CE in the Chinese population. METHODS: Patients were selected from the ANGEL registry and divided into LAA and CE groups...
2024: Clinical Interventions in Aging
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