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Cardioembolic stroke

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https://www.readbyqxmd.com/read/29457918/quality-of-life-among-patients-during-subacute-phase-following-stroke-during-hospitalisation-period-in-shanghai
#1
Jiang Jingwen, Jin Han, Zhang Yu, Huang Xiaojun, Zhuang Junpeng, Shen Fanxia, Liu Jianrong
OBJECTIVE: This study aimed to investigate the factors influencing the quality of life of in-hospital subacute stroke patients. METHODS: The patients of subacute stroke (within four weeks) in our institution between 2015 and 2016 were recruited. Patients' characteristics and QOL were obtained from medical charts and stroke-specific quality of life scale (SS-QOL). Associations of each domain in SS-QOL with socio-demographic, clinical factors and patient satisfaction were investigated using the linear regression models...
February 19, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29457494/management-of-phenobarbital-and-apixaban-interaction-in-recurrent-cardioembolic-stroke
#2
Philip K King, Trevor A Stump, Allyn M Walkama, Benjamin M Ash, Susana M Bowling
No abstract text is available yet for this article.
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29453088/serum-matrix-metalloproteinase-8-tissue-inhibitor-of-metalloproteinase-and-myeloperoxidase-in-ischemic-stroke
#3
Frederick Palm, Pirkko J Pussinen, Anton Safer, Taina Tervahartiala, Timo Sorsa, Christian Urbanek, Heiko Becher, Armin J Grau
BACKGROUND AND AIMS: Matrix metalloproteinase (MMP)-8 and myeloperoxidase (MPO) may contribute to cerebral damage in acute ischemic stroke. We tested the hypothesis that levels of MPO, MMP-8 and the ratio between MMP-8 and its regulator, tissue inhibitor of metalloproteinase (TIMP-1), are increased in acute ischemic stroke and its etiologic subgroups and they correlate with stroke severity. METHODS: In a cross-sectional case-control study, serum concentrations of MMP-8, MPO and TIMP-1 were assessed within 24 h after admission in 470 first-ever ischemic stroke patients and 809 age- and sex-matched controls, randomly selected from the population...
February 8, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29449280/prediction-of-the-multisegment-clot-sign-on-dynamic-ct-angiography-of-cardioembolic-stroke
#4
Z Chen, F Shi, M Zhang, X Gong, L Lin, M Lou
BACKGROUND AND PURPOSE: The multisegment clot sign has been observed at the site of large-artery occlusion in patients with acute ischemic stroke. This study aimed to assess its occurrence rate and relationship with stroke etiologies in patients with acute intracranial large-artery occlusion. MATERIALS AND METHODS: We included consecutive patients with acute ischemic stroke who had acute intracranial large-artery occlusion and underwent perfusion CT within 8 hours after stroke onset...
February 15, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29438871/red-cell-distribution-width-as-a-predictor-of-1-year-survival-in-ischemic-stroke-patients-treated-with-intravenous-thrombolysis
#5
João Pinho, Sofia Alexandra Marques, Eduardo Freitas, José Araújo, Mariana Taveira, José Nuno Alves, Carla Ferreira
INTRODUCTION: Red cell distribution width (RDW) has been found to be a prognostic marker in vascular diseases. Increased RDW predicted mortality and outcome after ischemic stroke however, the underlying mechanisms are unclear. Our study aimed to clarify the relation of RDW with stroke severity and 1-year survival. MATERIAL AND METHODS: Single-centre retrospective cohort study based on a prospective database of consecutive patients with acute anterior circulation ischemic stroke treated with intravenous thrombolysis (IVT) in a 9-year period...
February 7, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29426582/frequency-of-acute-and-subacute-infarcts-in-a-population-based-study
#6
Catherine Arnold Fiebelkorn, Prashanthi Vemuri, Alejandro A Rabinstein, Michelle M Mielke, Scott A Przybelski, Kejal Kantarci, David T Jones, Robert D Brown, David S Knopman, Ronald C Petersen, Clifford R Jack, Jonathan Graff-Radford
OBJECTIVE: To determine the frequency of incidental acute or subacute cerebral infarction (CI) in a population-based study. PATIENTS AND METHODS: We identified 2095 participants aged 50 to 98 years in the population-based Mayo Clinic Study of Aging from October 23, 2009, to October 5, 2016, with a usable diffusion tensor imaging (DTI) sequence (total scans=3230). Acute and subacute infarcts were identified by neuroradiologists. For each participant, vascular risk factors, medications, clinical symptoms, and neurological examination near the time of the CI were abstracted from the medical record...
February 6, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29421448/a-potential-new-risk-factor-for-stroke-streptococcus-mutans-with-collagen-binding-protein
#7
Chikanori Inenaga, Kazuya Hokamura, Kazuhiko Nakano, Ryota Nomura, Shuhei Naka, Toshihiko Ohashi, Takashi Ooshima, Nagato Kuriyama, Toshimitsu Hamasaki, Koichiro Wada, Kazuo Umemura, Tokutaro Tanaka
OBJECTIVE: Among human oral bacteria, particular kinds of Streptococcus mutans (SM) known as dental caries pathogen have a collagen-binding protein called Cnm and show platelet aggregation inhibition and matrix metalloproteinase-9 activation. We have previously reported that these strains may be a risk factor for intracerebral hemorrhage. As a major sample providing hospital, we report here the clinical details including intracranial aneurysms and ischemic stroke. METHODS: Under permission of our ethical committee, 429 samples of whole saliva were taken from patients who were admitted or visited our hospital from February 16, 2010 to February 28, 2011...
February 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29402843/sensitive-detection-of-atrial-fibrillation-in-acute-stroke-patients-by-short-term-bedside-electrocardiography-monitoring-software-analysis
#8
Linda Sarah Ross, Markus Bettin, Simon Kochhäuser, Martin Ritter, Jens Minnerup, Lars Eckardt, Florian Reinke, Ralf Dittrich
BACKGROUND: Atrial fibrillation (AF) is an important cause of stroke. Continuous electrocardiography (ECG) monitoring with software-based analysis algorithms has been suggested to enhance the AF detection rate. We investigated the ability of stroke risk analysis (SRA) in the detection of AF in acute stroke patients. METHODS: Consecutive stroke patients numbering 1,153 were screened. Patients with cardioembolic stroke related to AF (n = 296, paroxysmal n = 63, persistent n = 233) and patients with cryptogenic stroke (n = 309) after standard diagnostic work-up (bedside ECG monitoring, ultrasound, transesophageal echocardiography, 24 h Holter ECG) received SRA during their stay at the Stroke Unit...
January 17, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29402828/erythrocyte-rich-thrombus-is-associated-with-reduced-number-of-maneuvers-and-procedure-time-in-patients-with-acute-ischemic-stroke-undergoing-mechanical-thrombectomy
#9
Kota Maekawa, Masunari Shibata, Hideki Nakajima, Akane Mizutani, Yotaro Kitano, Masaru Seguchi, Masayoshi Yamasaki, Kazuto Kobayashi, Takanori Sano, Genshin Mori, Tadashi Yabana, Yutaka Naito, Shigetoshi Shimizu, Fumitaka Miya
BACKGROUND: Only few studies have investigated the relationship between the histopathology of retrieved thrombi and clinical outcomes. This study aimed to evaluate thrombus composition and its association with clinical, laboratory, and neurointerventional findings in patients treated by mechanical thrombectomy due to acute large vessel occlusion. METHODS: At our institution, 79 patients were treated by mechanical thrombectomy using a stent retriever and/or aspiration catheter between August 2015 and August 2016...
January 15, 2018: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/29398537/left-atrial-appendage-morphology-and-embolic-stroke-of-undetermined-source-a-cross-sectional-multicenter-pilot-study
#10
Shadi Yaghi, Andrew D Chang, Peter Hung, Brian Mac Grory, Scott Collins, Ajay Gupta, Jacques Reynolds, Caitlin B Finn, Morgan Hemendinger, Shawna M Cutting, Ryan A McTaggart, Mahesh Jayaraman, Audrey Leasure, Lauren Sansing, Nikhil Panda, Christopher Song, Antony Chu, Alexander Merkler, Gino Gialdini, Kevin N Sheth, Hooman Kamel, Mitchell S V Elkind, David Greer, Karen Furie, Michael Atalay
BACKGROUND: The left atrial appendage (LAA) is the main source of thrombus in atrial fibrillation, and there is an association between non-chicken wing (NCW) LAA morphology and stroke. We hypothesized that the prevalence of NCW LAA morphology would be higher among patients with cardioembolic (CE) stroke and embolic stroke of undetermined source (ESUS) than among those with noncardioembolic stroke (NCS). METHODS: This multicenter retrospective pilot study included consecutive patients with ischemic stroke from 3 comprehensive stroke centers who previously underwent a qualifying chest computed tomography (CT) to assess LAA morphology...
February 2, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29396105/ambulatory-blood-pressure-variability-within-the-first-24-hours-after-admission-and-outcomes-of-acute-ischemic-stroke
#11
Yu Zhang, Hong Wang, Ke Xu, Ping Wang, Xin-Yan Li, Jing-Bo Zhao, Ying Tang
Our purpose was to evaluate the value of blood pressure variability within the first 24 hours after admission in predicting outcomes of patients with acute ischemic stroke (AIS). A greater variability in systolic blood pressure (adjusted odds ratio [OR] = 1.801, 95% confidence interval [CI] = 1.167-2.779) was associated with poor discharge outcome, especially for nondiabetics (adjusted OR = 1.948, 95% CI = 1.184-3.205) and cardioembolism-related patients with AIS (OR = 7.650, 95% CI = 1.370-42.713)...
January 3, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29386475/ability-of-b-type-natriuretic-peptide-testing-to-predict-cardioembolic-stroke-in-the-general-population%C3%A3-comparisons-with-c-reactive-protein-and-urinary-albumin
#12
Motoyuki Nakamura, Yasuhiro Ishibashi, Fumitaka Tanaka, Shinichi Omama, Toshiyuki Onoda, Tomohiro Takahashi, Shuko Takahashi, Kozo Tanno, Masaki Ohsawa, Kiyomi Sakata, Makoto Koshiyama, Kuniaki Ogasawara, Akira Okayama
BACKGROUND: The ability of cardiovascular biomarkers to predict the incidence of stroke subtypes remains ill-defined in the general population.Methods and Results:The blood levels of B-type natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP) and urinary albumin corrected by urinary creatinine (UACR) were determined in a general population (n=13,575). The ability to predict the incidence of ischemic stroke subtypes (lacunar, atherothrombotic, cardioembolic) for each biomarker was assessed based on the area under the receiver-operating characteristic curve (AUC-ROC) and using Cox proportional hazard modeling...
January 30, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29384950/usefulness-of-multiphase-computed-tomography-angiography-in-a-patient-with-transient-ischemic-attack-in-the-hyperacute-phase-a-case-report
#13
Seungho Lee, Jun Soo Byun, Mi Sun Jung, Jeong-Min Kim, Taek-Kyun Nam
RATIONALE: Patients with transient ischemic attack (TIA) have the possibility of developing stroke in the future. To prevent recurrent TIA or future stroke, identifying the cause of TIA is important. However, about two-third of patients with TIA have negative findings on diffusion-weighted imaging (DWI).We present a case of TIA, the cause of which was identified using multiphase computed tomography angiography (MCTA) in the hyperacute phase of the disease. PATIENT CONCERNS: The patient was a 57-year-old man who was admitted to the emergency department for right-side weakness persisting for 1 hour...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29372390/impact-of-d-dimer-levels-for-short-term-or-long-term-outcomes-in-cryptogenic-stroke-patients
#14
Tomohisa Nezu, Takaya Kitano, Satoshi Kubo, Junichi Uemura, Shinji Yamashita, Takeshi Iwanaga, Takeshi Inoue, Naohisa Hosomi, Hirofumi Maruyama, Masayasu Matsumoto, Kazumi Kimura, Yoshiki Yagita
BACKGROUND: D-dimer levels are used in several clinical settings, such as in predicting venous thrombosis, cardioembolic stroke and cancer status. In the present study, we investigated the associations between plasma D-dimer levels at admission, clinical characteristics and mortality at discharge in cryptogenic stroke patients. We also investigated whether D-dimer levels can predict long-term outcomes in those patients, including those with and without right-to-left shunt (RLS). METHODS: Acute cryptogenic stroke patients (n = 295, 72 ± 13 years old) were consecutively enrolled and retrospectively analyzed...
January 25, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29371436/relationship-between-visceral-infarction-and-ischemic-stroke-subtype
#15
Caitlin Finn, Peter Hung, Praneil Patel, Ajay Gupta, Hooman Kamel
BACKGROUND AND PURPOSE: Most cryptogenic strokes are thought to have an embolic source. We sought to determine whether cryptogenic strokes are associated with visceral infarcts, which are usually embolic. METHODS: Among patients prospectively enrolled in CAESAR (Cornell Acute Stroke Academic Registry), we selected those with a contrast-enhanced abdominal computed tomographic scan within 1 year of admission. Our exposure variable was adjudicated stroke subtype per the Trial of ORG 10172 in Acute Stroke Treatment classification...
January 25, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29367736/statins-do-not-increase-markers-of-cerebral-angiopathies-in-patients-with-cardioembolic-stroke
#16
Joan Martí-Fàbregas, Santiago Medrano-Martorell, Elisa Merino, Luis Prats-Sánchez, Rebeca Marín, Raquel Delgado-Mederos, Pol Camps-Renom, Alejandro Martínez-Domeño, Manuel Gómez-Choco, Lidia Lara, Ignacio Casado-Naranjo, David Cánovas, Maria José Torres, Marimar Freijo, Ana Calleja, Yolanda Bravo, Dolores Cocho, Ana Rodríguez-Campello, Beatriz Zandio, Blanca Fuentes, Alicia de Felipe, Laura Llull, José Maestre, María Hernández, Moisès Garcés, Ana Maria De Arce-Borda, Ernest Palomeras, Manuel Rodríguez-Yáñez, Inma Díaz-Maroto, Marta Serrano, Jéssica Fernández-Domínguez, Jordi Sanahuja, Francisco Purroy, Marialuisa Zedde, Jordi Delgado-Mengual, Ignasi Gich
We investigated whether pre-treatment with statins is associated with surrogate markers of amyloid and hypertensive angiopathies in patients who need to start long-term oral anticoagulation therapy. A prospective multicenter study of patients naive for oral anticoagulants, who had an acute cardioembolic stroke. MRI was performed at admission to evaluate microbleeds, leukoaraiosis and superficial siderosis. We collected data on the specific statin compound, the dose and the statin intensity. We performed bivariate analyses and a logistic regression to investigate variables associated with microbleeds...
January 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29364390/anticoagulation-in-patients-with-cardiac-manifestations-of-chagas-disease-and-cardioembolic-ischemic-stroke
#17
Jean M C Monteiro, Daniel L San-Martin, Beatriz C G Silva, Pedro A P de Jesus, Jamary Oliveira Filho
To describe anticoagulation characteristics in patients with cardiac complications from Chagas disease and compare participants with and without cardioembolic ischemic stroke (CIS). A retrospective cohort of patients with Chagas disease, using anticoagulation, conducted from January 2011 to December 2014. Forty-two patients with Chagas disease who were using anticoagulation were studied (age 62.9±12.4 years), 59.5% female and 47.6% with previous CIS, 78.6% with non-valvular atrial fibrillation and 69.7% with dilated cardiomyopathy...
January 2018: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29357035/cryptogenic-acute-limb-ischemia-a-retrospective-cohort-study-defining-a-previously-undescribed-clinical-entity
#18
Dylan Mart, Joseph Shatzel, Thomas DeLoughery
Acute limb ischemia (ALI) is generally secondary to cardioembolism or progression of peripheral vascular disease, however, a discrete population of patients with ALI exists in which no precipitant is ever established. Unlike cryptogenic arterial occlusion in other arenas, such as cryptogenic stroke, cryptogenic acute limb ischemia (cALI) has not been well-described, and no routine management has been established. The aim of this study is to describe patients with cALI, and the risk of recurrence based on the treatment they received...
January 22, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29339702/efficacy-and-safety-of-oral-anticoagulation-in-elderly-patients-with-atrial-fibrillation
#19
Ilaria Cavallari, Giuseppe Patti
Elderly patients with atrial fibrillation are at a higher risk of both ischemic and bleeding events compared with younger patients; therefore, balancing risks and benefits of antithrombotic strategies in this population is crucial. Recent studies have shown that because the risk of stroke increases with age more than the risk of bleeding, the absolute benefit of oral anticoagulation is the highest in elderly patients in whom it outweighs the risk of bleeding. Direct oral anticoagulants (DOACs) have been developed as a treatment for the prevention of cardioembolic stroke to overcome some limitations of warfarin, such as the need for frequent monitoring, labile INR values requiring frequent dose adjustment, dietary and drugs interactions, and increased risk of intracranial bleeding...
January 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29335336/periodontal-disease-regular-dental-care-use-and-incident-ischemic-stroke
#20
Souvik Sen, Lauren D Giamberardino, Kevin Moss, Thiago Morelli, Wayne D Rosamond, Rebecca F Gottesman, James Beck, Steven Offenbacher
BACKGROUND AND PURPOSE: Periodontal disease is independently associated with cardiovascular disease. Identification of periodontal disease as a risk factor for incident ischemic stroke raises the possibility that regular dental care utilization may reduce the stroke risk. METHODS: In the ARIC (Atherosclerosis Risk in Communities) study, pattern of dental visits were classified as regular or episodic dental care users. In the ancillary dental ARIC study, selected subjects from ARIC underwent fullmouth periodontal measurements collected at 6 sites per tooth and classified into 7 periodontal profile classes (PPCs)...
January 15, 2018: Stroke; a Journal of Cerebral Circulation
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