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Cardioembolic stroke

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https://www.readbyqxmd.com/read/29025779/scorpion-bite-induced-ischaemic-stroke
#1
Rakesh Reddy C, Nandakishore Bompelli, Vikram Khardenavis, Anirudda Deshpande
We report a 54-year-old woman with scorpion bite. After 3 hours of admission, the patient developed sudden onset tachycardia with hypotension. Cardiac evaluation showed raised creatine kinase MB isoenzyme was elevated; ECG and two-dimensional echocardiography findings were suggestive of myocarditis. Subsequently, she developed transient ventricular tachycardia before developing abrupt onset, right hemiplegia, global aphasia and progressive worsening of sensorium 12 hours after the bite. MRI of brain revealed massive left middle cerebral artery (MCA) territory infarct...
October 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29020353/differential-effects-of-pcsk9-variants-on-risk-of-coronary-disease-and-ischaemic-stroke
#2
Jemma C Hopewell, Rainer Malik, Elsa Valdés-Márquez, Bradford B Worrall, Rory Collins
Aims: PCSK9 genetic variants that have large effects on low-density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD) have prompted the development of therapeutic PCSK9-inhibition. However, there is limited evidence that PCSK9 variants are associated with ischaemic stroke (IS). Methods and results: Associations of the loss-of-function PCSK9 genetic variant (rs11591147; R46L), and five additional PCSK9 variants, with IS and IS subtypes (cardioembolic, large vessel, and small vessel) were estimated in a meta-analysis involving 10 307 IS cases and 19 326 controls of European ancestry...
July 17, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28991905/the-presence-and-severity-of-cerebral-small-vessel-disease-increases-the-frequency-of-stroke-in-a-cohort-of-patients-with-large-artery-occlusive-disease
#3
Ki-Woong Nam, Hyung-Min Kwon, Jae-Sung Lim, Moon-Ku Han, Hyunwoo Nam, Yong-Seok Lee
BACKGROUND: Cerebral small vessel disease (SVD) commonly coexists with large artery atherosclerosis (LAA). AIM: We evaluate the effect of SVD on stroke recurrence in patients for ischemic stroke with LAA. METHODS: We consecutively collected first-ever ischemic stroke patients who were classified as LAA mechanism between Jan 2010 and Dec 2013. Univariate and multivariate Cox analyses were performed to evaluate the association between the 2-year recurrence and demographic, clinical, and radiological factors...
2017: PloS One
https://www.readbyqxmd.com/read/28980580/-total-antioxidant-status-of-blood-in-various-types-of-ischemic-stroke
#4
Yu I Kravtsov, E Yu Kravtsova, S I Selezneva, D Yu Sosnin
AIM: To study the antioxidant status (AOS) of blood serum of patients in the acute period in patients with a variety of pathogenic forms of ischemic stroke (IS). MATERIAL AND METHODS: A total of 99 patients (study group) with different types of ischemic stroke (IS): with atherothrombotic variant (n=74) IS, with cardioembolic (n=15) with lacunar type (n=10). The control group consisted of 15 persons. Total antioxidant status (TAS) in the blood serum was examined by the test system 'General antioxidatic status - Novo' ('Vector-Best', Russia) for 1-2 days from the onset of the disease...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28963520/interplay-between-3-utr-polymorphisms-in-the-methylenetetrahydrofolate-reductase-mthfr-gene-and-the-risk-of-ischemic-stroke
#5
Jung Oh Kim, Han Sung Park, Chang Soo Ryu, Jung-Won Shin, Jinkwon Kim, Seung Hun Oh, Ok Joon Kim, Nam Keun Kim
Stroke incidence is a multifactorial disease and especially hyperhomocysteinemia is associated with a higher risk of stroke. Previous studies have reported a folate metabolism disorder associated with the MTHFR gene. We investigated four single nucleotide polymorphisms in the MTHFR 3'-UTR [2572 C > A (rs4846049), 4869 C > G (rs1537514), 5488 C > T (rs3737967), and 6685 T > C (rs4846048)] to elucidate associations between ischemic stroke prevalence and prognosis. We examined 511 consecutive patients with ischemic stroke...
September 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28954878/col4a2-is-associated-with-lacunar-ischemic-stroke-and-deep-ich-meta-analyses-among-21-500-cases-and-40-600-controls
#6
Kristiina Rannikmäe, Vhinoth Sivakumaran, Henry Millar, Rainer Malik, Christopher D Anderson, Mike Chong, Tushar Dave, Guido J Falcone, Israel Fernandez-Cadenas, Jordi Jimenez-Conde, Arne Lindgren, Joan Montaner, Martin O'Donnell, Guillaume Paré, Farid Radmanesh, Natalia S Rost, Agnieszka Slowik, Martin Söderholm, Matthew Traylor, Sara L Pulit, Sudha Seshadri, Brad B Worrall, Daniel Woo, Hugh S Markus, Braxton D Mitchell, Martin Dichgans, Jonathan Rosand, Cathie L M Sudlow
OBJECTIVE: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD. METHODS: We meta-analyzed genotype data from individuals of European ancestry to determine associations of common single nucleotide polymorphisms (SNPs) in 6 familial cerebral SVD genes (COL4A1, COL4A2, NOTCH3, HTRA1, TREX1, and CECR1) with intracerebral hemorrhage (ICH) (deep, lobar, all; 1,878 cases, 2,830 controls) and ischemic stroke (IS) (lacunar, cardioembolic, large vessel disease, all; 19,569 cases, 37,853 controls)...
September 27, 2017: Neurology
https://www.readbyqxmd.com/read/28940906/post-stroke-diastolic-blood-pressure-and-risk-of-recurrent-vascular-events
#7
J-H Park, B Ovbiagele
BACKGROUND AND PURPOSE: Recent clinical trials and expert consensus guidelines have typically focused on the issue of systolic blood pressure (SBP) targets for reducing vascular risk. However, little is known about the relationship of the diastolic BP (DBP) level with vascular outcomes after a stroke. METHODS: A multicenter trial dataset involving 3680 recent (<4 months) non-cardioembolic stroke patients followed for 2 years was analyzed. Subjects were categorized per mean DBP level (mmHg) during follow-up: low-normal (<70), normal (70 to <80), high-normal (80-89) and high (≥90)...
November 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28939865/a-replication-study-of-genetic-risk-loci-for-ischemic-stroke-in-a-dutch-population-a-case-control-study
#8
Allard J Hauer, Sara L Pulit, Leonard H van den Berg, Paul I W de Bakker, Jan H Veldink, Ynte M Ruigrok
We aimed to replicate reported associations of 10 SNPs at eight distinct loci with overall ischemic stroke (IS) and its subtypes in an independent cohort of Dutch IS patients. We included 1,375 IS patients enrolled in a prospective multicenter hospital-based cohort in the Netherlands, and 1,533 population-level controls of Dutch descent. We tested these SNPs for association with overall IS and its subtypes (large artery atherosclerosis, small vessel disease and cardioembolic stroke (CE), as classified by TOAST) using an additive multivariable logistic regression model, adjusting for age and sex...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924104/validation-of-the-r2chads2-and-chads2-scores-for-predicting-post-stroke-cognitive-impairment
#9
Kazuo Washida, Hisatomo Kowa, Hirotoshi Hamaguchi, Fumio Kanda, Tatsushi Toda
Objective Post-stroke cognitive impairment often afflicts stroke survivors and is a major obstacle both for cognitive and physical rehabilitation. Stroke risk scores ["Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, Stroke" (CHADS2) and "CHADS2 + creatinine clearance <60 mL/min" (R2CHADS2)] are used to assess the future risk of cardioembolic stroke in patients with atrial fibrillation (AF). However, congestive heart failure, hypertension, aging, diabetes mellitus, stroke, and renal dysfunction are also risk factors for cognitive impairment...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28924103/pravastatin-reduces-the-risk-of-atherothrombotic-stroke-when-administered-within-six-months-of-an-initial-stroke-event
#10
Naohisa Hosomi, Yoji Nagai, Kazuo Kitagawa, Yoko Nakagawa, Shiro Aoki, Tomohisa Nezu, Tatsuo Kagimura, Hirofumi Maruyama, Hideki Origasa, Kazuo Minematsu, Shinichiro Uchiyama, Masayasu Matsumoto
AIMS: The J-STARS study examined whether pravastatin (10 mg/day) reduces recurrence of stroke in non-cardioembolic ischemic stroke patients who were enrolled within 1 month to 3 years after initial stroke events (ClinicalTrials.gov, NCT00221104). The main results showed that the frequency of atherothrombotic stroke was low in pravastatin-treated patients, although no effect of pravastatin was found for the other stroke subtypes. We evaluated differences of early (within 6 months) or late (after 6 months) pravastatin treatment benefits on the incidence of stroke or transient ischemic attack (TIA), as well as atherothrombotic stroke and the other subtypes...
September 16, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28922363/predictors-of-post-thrombolysis-symptomatic-intracranial-hemorrhage-in-chinese-patients-with-acute-ischemic-stroke
#11
Mingyong Liu, Yuesong Pan, Lichun Zhou, Yongjun Wang
BACKGROUND AND PURPOSE: Predictors of symptomatic intracranial hemorrhage (sICH) in Chinese patients with acute ischemic stroke treated with recombinant tissue plasminogen activator remain unclear. METHODS: Data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) study were assessed to explore risk factors for symptomatic intracranial hemorrhage after intravenous thrombolysis. Three candidate sICH definitions were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28904084/relevance-of-supraventricular-runs-detected-after-cerebral-ischemia
#12
Mark Weber-Krüger, Constanze Lutz, Antonia Zapf, Raoul Stahrenberg, Joachim Seegers, Janin Witzenhausen, Katrin Wasser, Gerd Hasenfuß, Klaus Gröschel, Rolf Wachter
OBJECTIVE: Prolonged ECG monitoring after stroke frequently reveals short paroxysmal atrial fibrillation (pAF) and supraventricular (SV) runs. The minimal duration of atrial fibrillation (AF) required to induce cardioembolism, the relevance of SV runs, and whether short pAF results from cerebral damage itself are currently being debated. We aimed to study the relevance of SV runs and short pAF detected by prolonged Holter ECG after cerebral ischemia during long-term follow-up. METHODS: Analysis is from the prospective Find-AF trial (ISRCTN46104198)...
September 13, 2017: Neurology
https://www.readbyqxmd.com/read/28885101/association-between-the-maximal-distance-of-atrial-septal-protrusion-and-cryptogenic-stroke
#13
Keisuke Tokunaga, Masahiro Yasaka, Takahiro Kuwashiro, Seiji Gotoh, Asako Nakamura, Go Takaguchi, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, Yasushi Okada
Background and purpose Previous studies have suggested that atrial septal aneurysm is a potential risk factor for cerebral embolism. However, the association between the level of atrial septal protrusion and cerebral embolism is still unclear. The purpose of the present study was to assess the association between the maximal distance of atrial septal protrusion and cryptogenic stroke. Methods A total of 588 consecutive acute ischemic stroke patients (70 ± 11 (mean ± SD) years, 401 men) who underwent transesophageal echocardiography were enrolled...
December 20, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28864598/relationship-of-preexisting-cardiovascular-comorbidities-to-newly-diagnosed-atrial-fibrillation-after-ischemic-stroke
#14
Arnaud Bisson, Nicolas Clementy, Alexandre Bodin, Denis Angoulvant, Dominique Babuty, Gregory Y H Lip, Laurent Fauchier
BACKGROUND AND PURPOSE: There remains uncertainty as whether newly diagnosed atrial fibrillation (AF) after ischemic stroke reflects underlying heart disease and represents an increased risk of cardioembolic stroke, or whether it is triggered by neurogenic mechanisms. We aimed to determine whether cardiovascular comorbidities in patients with new AF after ischemic stroke differ from patients with previous known AF or without AF. METHODS: This French longitudinal cohort study was based on the database covering hospital care from 2009 to 2012 for the entire population...
October 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28862284/detection-of-atrial-fibrillation-in-patients-with-embolic-stroke-of-undetermined-source-by-prolonged-monitoring-with-implantable-loop-recorders
#15
Carsten Israel, Alkisti Kitsiou, Malik Kalyani, Sameera Deelawar, Lucy Ekosso Ejangue, Andreas Rogalewski, Christoph Hagemeister, Jens Minnerup, Wolf-Rüdiger Schäbitz
Recently, the clinical entity embolic stroke of undetermined source (ESUS) has been defined for patients with ischemic strokes, where neither a cardioembolic nor a non-cardiac source can be detected. These patients may suffer from asymptomatic atrial fibrillation (AF), terminating spontaneously and thus eluding detection. Implantable loop recorders (ILR) with automatic AF detection algorithms can detect short-lasting, subclinical AF. The aim of this study was to prospectively assess and predict AF detection in patients with ESUS using ILR with daily remote interrogation...
October 5, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28858408/clinical-characteristics-of-stroke-occurring-in-the-toilet-are-older-adults-more-vulnerable
#16
Joji Inamasu, Kazuhiro Tomiyasu, Satoru Miyatake, Keita Mayanagi, Masami Yoshii, Masashi Nakatsukasa
AIM: While autonomic imbalance during defecation/micturition can cause hemodynamic instability, stroke occurring in the toilet has rarely been investigated. The objective of the present study was to clarify the frequency and clinical characteristics of toilet-related stroke. METHODS: Clinical data prospectively acquired between January 2011 and December 2015 on 1939 patients with acute stroke (1224 cerebral infarctions [CI], 505 intracerebral hemorrhages [ICH] and 210 subarachnoid hemorrhages [SAH]) were reviewed to identify patients with a toilet-related stroke...
August 31, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28844546/etiological-classification-of-stroke-in-patients-with-chagas-disease-using-toast-causative-classification-system-toast-and-ascod-phenotyping
#17
Rodrigo de Paiva Bezerra, Maramélia Araújo de Miranda Alves, Adriana Bastos Conforto, Daniela Laranja Gomes Rodrigues, Gisele Sampaio Silva
BACKGROUND: Cardioembolism is considered a major pathophysiological mechanism in patients with ischemic stroke (IS) and Chagas disease (CD). However, a previous study reported that other stroke subtypes are present in more than 40% of CD patients according to the TOAST classification. Therefore, the aim of our study was to evaluate the etiologic classification of stroke in patients with CD using the Causative Classification System (CCS), the ASCOD, and the TOAST classifications in a prospective cohort of patients...
August 22, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28843428/association-of-matrix-metalloproteinase-3-gene-5a-6a-polymorphism-with-the-recurrence-of-ischemic-stroke-a-prospective-observational-study
#18
Xiaoya Huang, Qiang Ye, Zheng Zhang, Xiangdong Huang, Zhenguo Zhu, Yanyan Chen, Jia Li, Siyan Chen, Niange Xia, Xinlei Mao, Liya Han, Zusen Ye
Studies have demonstrated that matrix metalloproteinase-3 (MMP-3) is involved in the development and progression of atherosclerosis. However, there is no information available on the association of MMP-3 5A/6A polymorphism with recurrent ischemic stroke (IS) in different IS subtypes. We investigated the potential associations between MMP-3 serum level and -1171 5A/6A polymorphism and the recurrence of IS in a Chinese population. Consecutive acute first-ever IS patients were enrolled between August 2008 and October 2013...
August 23, 2017: Brain Research
https://www.readbyqxmd.com/read/28837206/neutrophil-extracellular-traps-are-increased-in-patients-with-acute-ischemic-stroke-prognostic-significance
#19
Juana Vallés, Aída Lago, María Teresa Santos, Ana María Latorre, José I Tembl, Juan B Salom, Candela Nieves, Antonio Moscardó
Neutrophil extracellular traps (NETs) are networks of DNA, histones, and proteolytic enzymes produced by activated neutrophils through different mechanisms. NET formation is promoted by activated platelets and can in turn activate platelets, thus favoring thrombotic processes. NETs have been detected in venous and arterial thrombosis, but data in stroke are scarce. The aim of this study was to evaluate NETs in the plasma of patients with acute ischemic stroke and their potential association with baseline clinical characteristics, stroke severity, and one-year clinical outcomes...
October 5, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28830976/omega-3-fatty-acids-and-incident-ischemic-stroke-and-its-atherothrombotic-and-cardioembolic-subtypes-in-3-us-cohorts
#20
MULTICENTER STUDY
Hamidreza Saber, Mohammad Yawar Yakoob, Peilin Shi, W T Longstreth, Rozenn N Lemaitre, David Siscovick, Kathryn M Rexrode, Walter C Willett, Dariush Mozaffarian
BACKGROUND AND PURPOSE: The associations of individual long-chain n-3 polyunsaturated fatty acids with incident ischemic stroke and its main subtypes are not well established. We aimed to investigate prospectively the relationship of circulating eicosapentaenoic acid, docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with risk of total ischemic, atherothrombotic, and cardioembolic stroke. METHODS: We measured circulating phospholipid fatty acids at baseline in 3 separate US cohorts: CHS (Cardiovascular Health Study), NHS (Nurses' Health Study), and HPFS (Health Professionals Follow-Up Study)...
October 2017: Stroke; a Journal of Cerebral Circulation
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