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https://www.readbyqxmd.com/read/29334719/-human-papillomavirus-infection-and-vaccination
#1
Z H He, Z Q Kou, A Q Xu
Human papillomavirus (HPV) is an infection that can be sexually transmitted and result in health consequences. Persistent high-risk HPV infection can lead to various cancers and is the essential cause of cervical cancer. HPV vaccine can prevent the HPV infection and thus the incidence of cervical cancer. In this review we introduced the prevalence of HPV infection and vaccination, and the prevention and early detection of cervical cancer. We also introduced the present knowledge and awareness of HPV infection and HPV vaccine in Chinese...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334204/detection-of-chlamydia-trachomatis-in-pap-smear-samples-from-south-khorasan-province-of-iran
#2
Davod Javanmard, Mahmoodreza Behravan, Malaknaz Ghannadkafi, Alireza Salehabadi, Masood Ziaee, Mohammad Hasan Namaei
Background: Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection (STI), leads to pelvic inflammatory disease, infertility and chronic pelvic pain in women as well as an increased risk of vertical transmission, conjunctivitis and pneumonitis in infants. It may also be a co-factor along with human papillomavirus (HPV) in cervical cancer progression. We aimed to determine the prevalence of CT genotypes in genital specimens of women from South Khorasan, Iran and to test the association between CT and cytology statistics...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29331867/classification-and-evolution-of-human-papillomavirus-genome-variants-alpha-5-hpv26-51-69-82-alpha-6-hpv30-53-56-66-alpha-11-hpv34-73-alpha-13-hpv54-and-alpha-3-hpv61
#3
Zigui Chen, Mark Schiffman, Rolando Herrero, Rob DeSalle, Kathryn Anastos, Michel Segondy, Vikrant V Sahasrabuddhe, Patti E Gravitt, Ann W Hsing, Paul K S Chan, Robert D Burk
HPV variants from the same type can be classified into lineages and sublineages based on the complete genome differences and the phylogenetic topologies. We examined nucleotide variations of twelve HPV types within the species Alpha-5 (HPV26, 51, 69, 82), Alpha-6 (HPV30, 53, 56, 66), Alpha-11 (HPV34, 73), Alpha-13 (HPV54) and Alpha-3 (HPV61) by analyzing 1432 partial sequences and 181 complete genomes from multiple geographic populations. The inter-lineage and inter-sublineage mean differences of HPV variants ranged between 0...
January 11, 2018: Virology
https://www.readbyqxmd.com/read/29331480/human-papillomavirus-hpv-18-genetic-variants-and-cervical-cancer-risk-in-taizhou-area-china
#4
Hui-Hui Xu, Ling-Zhi Zheng, Ai-Fen Lin, Shan-Shan Dong, Ze-Ying Chai, Wei-Hua Yan
Human papillomavirus (HPV) type 18 is predominantly associated with the development of cervical adenocarcinomas, whereas data on HPV18 genetic variability in China are limited. HPV18 genetic variants were formed phylogenetic tree, including lineages A, B, and C. We aimed to evaluate the diversity of HPV18 genetic variants by sequencing the entire E6, E7 and L1 genes. Between 2012 and 2015, a total of 138 (0.8%, 138/17669) women with single HPV18 infection were selected in this study. Finally, we observed 122 HPV18 isolates of the complete E6-E7-L1 sequences, and obtained 36 distinct variation patterns which the accession GenBank numbers as KY457805-KY457840...
January 10, 2018: Gene
https://www.readbyqxmd.com/read/29331245/outsmart-hpv-acceptability-and-short-term-effects-of-a-web-based-hpv-vaccination-intervention-for-young-adult-gay-and-bisexual-men
#5
Annie-Laurie McRee, Abigail Shoben, Jose A Bauermeister, Mira L Katz, Electra D Paskett, Paul L Reiter
BACKGROUND: Effective interventions to promote human papillomavirus (HPV) vaccination are needed, particularly among populations at increased risk of HPV-related disease. We developed and pilot tested a web-based intervention, Outsmart HPV, to promote HPV vaccination among young gay and bisexual men (YGBM). METHODS: In 2016, we recruited a national sample (n = 150) of YGBM ages 18-25 in the United States who had not received any doses of HPV vaccine. Participants were randomized to receive either standard HPV vaccination information (control) or population-targeted, individually-tailored content (Outsmart HPV intervention)...
January 10, 2018: Vaccine
https://www.readbyqxmd.com/read/29331076/submental-artery-island-flap-with-simultaneous-level-i-neck-dissection
#6
Antoine Eskander, Daniel Strigenz, Nolan Seim, Enver Ozer
BACKGROUND: The purpose of this study was to illustrate the submental island flap elevation technique with simultaneous level I neck dissection followed by the inset and reconstruction of an oropharyngeal defect. METHODS: A 63-year-old patient with a T2N1M0 human papillomavirus-positive squamous cell carcinoma of the tonsil was treated with concurrent chemoradiotherapy (cisplatin + 66 Gy). A local recurrence 2.5 years after treatment was treated surgically and reconstructed with a submental island flap...
January 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29330310/social-determinants-of-community-level-human-papillomavirus-vaccination-coverage-in-a-school-based-vaccination-programme
#7
Stephen Jean, Malak Elshafei, Alison Buttenheim
OBJECTIVE: To assess social patterns in human papillomavirus (HPV) vaccine coverage in a school-based, government-funded vaccination programme located within a single-payer universal healthcare system. DESIGN: We conducted a cross-sectional analysis of HPV vaccine uptake data for the 2013-2014 school year for 131 local authorities in England, and then evaluated the association between vaccine uptake and socioeconomic status at the aggregate level. DATA SOURCES: HPV vaccination coverage data from Public Health England's vaccine uptake guidance and the UK's March 2011 Census...
January 12, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29330033/service-quality-and-parents-willingness-to-get-adolescents-hpv-vaccine-from-pharmacists
#8
Parth D Shah, William A Calo, Macary W Marciniak, Carol E Golin, Betsy L Sleath, Noel T Brewer
We sought to examine whether pharmacy service quality was associated with parents' willingness to have immunizing pharmacists administer human papillomavirus (HPV) vaccine to their adolescent children. Participants were a national sample of 1504 US parents of adolescents ages 11 to 17 who completed an online survey in 2014. Analyses used structural equation modeling. Parents rated service quality and feelings of satisfaction with their pharmacies as moderate to high. Many (44%) were willing to get HPV vaccine from immunizing pharmacists for their adolescent children...
January 9, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29329167/a-physician-s-recommendation-for-hpv-vaccination-what-makes-african-american-mothers-compliant
#9
Jennifer L Cunningham-Erves, Kendria D Kelly-Taylor, Tilicia L Mayo-Gamble, Jason A Deakings, Laura L Talbott
BACKGROUND: Improving HPV vaccination among African American (AA) female adolescents to reduce the cervical cancer burden is important and cost-effective. The study objective is to identify factors most influential to AA mothers' likelihood to comply with a physician's recommendation to get their daughters the human papillomavirus (HPV) vaccine. METHODS: We conducted a cross-sectional survey. Participants were recruited through online and community sites (i.e. schools, community centers, etc...
January 11, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29328473/detection-of-high-grade-neoplasia-in-air-dried-cervical-pap-smears-by-a-microrna-based-classifier
#10
Mikhail K Ivanov, Sergei E Titov, Sergei A Glushkov, Victoria V Dzyubenko, Anastasia V Malek, Polina A Arkhangelskaya, Roman B Samsonov, Andrey A Mikhetko, Elena V Bakhidze, Igor V Berlev, Nikolay N Kolesnikov
Recent studies have shown that changes in the expression levels of certain microRNAs correlate with the degree of severity of cervical lesions. The aim of the present study was to develop a microRNA-based classifier for the detection of high-grade cervical intraepithelial neoplasia (CIN ≥2) in cytological samples from patients with different high-risk human papillomavirus (HR-HPV) viral loads. For this purpose, raw RT-qPCR data for 25 candidate microRNAs, U6 snRNA and human DNA in air-dried PAP smears from 174 women with different cervical cytological diagnoses, 144 of which were HR-HPV-positive [40 negative for intraepithelial lesion or malignancy (NILM), 34 low-grade squamous intraepithelial lesions (L-SIL), 57 high-grade squamous intraepithelial lesions (H-SIL), 43 invasive cancers], were statistically processed...
January 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29327784/transoral-robotic-surgery-for-oropharyngeal-carcinoma-surgical-margins-and-oncologic-outcomes
#11
Eric J Moore, Kathryn M Van Abel, Daniel L Price, Christine M Lohse, Kerry D Olsen, Ryan S Jackson, Eliot J Martin
BACKGROUND: This study presents oncologic outcomes after transoral robotic surgery (TORS) ± adjuvant therapy for oropharyngeal squamous cell carcinoma (SCC). METHODS: Three hundred fourteen patients undergoing TORS ± adjuvant therapy for oropharyngeal SCC from May 1, 2007, to May 31, 2015, are analyzed. RESULTS: Median follow-up was 3.3 years (interquartile range [IQR] 1.8-5.3 years; range 1 day to 9.3 years). Estimated locoregional recurrence-free survival, distant metastasis-free survival (DMFS), overall survival (OS), and cancer-specific survival (CSS) rates (95% confidence interval [CI] number still at risk) at 5 years after surgery were 92% (88-95; 92), 90% (86-94; 92), 86% (82-92; 98), and 94% (91-97; 98), respectively...
January 12, 2018: Head & Neck
https://www.readbyqxmd.com/read/29327614/intracellular-african-swine-fever-virus-dna-remains-unmethylated-in-infected-vero-cells
#12
Stefanie Weber, Astghik Hakobyan, Hovakim Zakaryan, Walter Doerfler
AIM: Sequence-specific CpG methylation of eukaryotic promoters is an important epigenetic signal for long-term gene silencing. We have now studied the methylation status of African swine fever virus (ASFV) DNA at various times after infection of Vero cells in culture. METHODS & RESULTS: ASFV DNA was detectable throughout the infection cycle and was found unmethylated in productively infected Vero cells as documented by bisulfite sequencing of 13 viral DNA segments...
January 12, 2018: Epigenomics
https://www.readbyqxmd.com/read/29327306/strengthening-the-case-for-gender-neutral-and-the-nonavalent-hpv-vaccine
#13
REVIEW
Justin M Hintze, James P O'Neill
PURPOSE: The purpose of this review is to highlight the benefits of gender-neutral and the nonavalent human papillomavirus vaccination. Human papillomavirus infection is the most commonly sexually transmitted disease and is known to cause several types of cancers, including cervical, vulvar, vaginal, penile, oropharyngeal, anal, and rectal. 5% of cancers every year are attributable to human papillomavirus infection, with cervical cancer the most common and oropharyngeal cancer estimated to surpass the incidence of cervical cancer by 2020...
January 11, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29327232/comparative-evaluation-of-the-omniplex-hpv-and-rfmp-hpv-papillotyper-for-detecting-human-papillomavirus-genotypes-in-cervical-specimens
#14
Young Ahn Yoon, Bo-Hyun Kim, Su-Hak Heo, Hwi Jun Kim, Young-Jin Choi
Human papillomavirus (HPV) is a major cause of cervical neoplasia development. HPV screening is very important because early treatment can prevent cervical cancer. Omniplex-HPV is a polymerase chain reaction followed by Luminex xMAP bead microarray technology that is designed for detecting 40 HPV genotypes. The aim of this study is to evaluate the analytical and clinical performance of the Omniplex-HPV in comparison with that of the commercially available RFMP (restriction fragment mass polymorphism) HPV PapilloTyper...
January 11, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29327043/association-of-oral-microbiome-with-risk-for-incident-head-and-neck-squamous-cell-cancer
#15
Richard B Hayes, Jiyoung Ahn, Xiaozhou Fan, Brandilyn A Peters, Yingfei Ma, Liying Yang, Ilir Agalliu, Robert D Burk, Ian Ganly, Mark P Purdue, Neal D Freedman, Susan M Gapstur, Zhiheng Pei
Importance: Case-control studies show a possible relationship between oral bacteria and head and neck squamous cell cancer (HNSCC). Prospective studies are needed to examine the temporal relationship between oral microbiome and subsequent risk of HNSCC. Objective: To prospectively examine associations between the oral microbiome and incident HNSCC. Design, Setting, and Participants: This nested case-control study was carried out in 2 prospective cohort studies: the American Cancer Society Cancer Prevention Study II Nutrition Cohort (CPS-II) and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)...
January 11, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29326178/impact-of-replacing-cytology-with-human-papillomavirus-testing-for-cervical-cancer-screening-on-the-prevalence-of-trichomonas-vaginalis-a-modelling-study
#16
Ben B Hui, Caitlin P Reulein, Rebecca J Guy, Basil Donovan, Jane S Hocking, Matthew G Law, David G Regan
OBJECTIVES: Trichomonas vaginalis (TV) is the most common curable STI worldwide and is associated with increased risk of HIV acquisition and serious reproductive morbidities. The prevalence of TV infection is very low in Australian cities, and this is thought to be at least partly due to incidental detection and treatment of TV in women participating in the cervical cytology screening programme. In 2017, the national cervical screening programme will transition to a new model based on testing for high-risk (HR) human papillomavirus (HPV), with a reduced frequency and commencement at an older age...
January 11, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29325530/knowledge-of-cervical-cancer-and-hpv-vaccine-in-bangladeshi-women-a-population-based-cross-sectional-study
#17
Jessica Yasmine Islam, Fatema Khatun, Anadil Alam, Farhana Sultana, Afsana Bhuiyan, Nazmul Alam, Laura Reichenbach, Lena Marions, Mustafizur Rahman, Quamrun Nahar
BACKGROUND: The objective of this study was to assess the level of knowledge of cervical cancer among Bangladeshi women and to assess their willingness to receive the human papillomavirus (HPV) vaccine. METHODS: A population-based, cross-sectional survey was conducted from July to December 2011 in one urban and one rural area of Bangladesh. A total of 2037 ever-married women, aged 14 to 64 years, were interviewed using a structured questionnaire. Data on socio-demographic characteristics and knowledge of cervical cancer were collected...
January 11, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29325528/knowledge-attitudes-and-practices-regarding-cervical-cancer-and-screening-among-women-visiting-primary-health-care-centres-in-bahrain
#18
Ghufran Jassim, Alaaeddin Obeid, Huda A Al Nasheet
BACKGROUND: Cervical cancer is one of the most common cancers among women, with 80% of the cases occurring in developing countries. Cervical cancer is largely preventable by effective screening programs. This has not been possible with opportunistic screening and its low use in the Kingdom of Bahrain. The objective of this study was to explore the knowledge, attitudes, and practices of women attending primary care health centres for cervical cancer screening. METHODS: This was a cross-sectional study of 300 women attending primary health care centres in Bahrain...
January 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29324878/the-curious-case-of-apobec3-activation-by-cancer-associated-human-papillomaviruses
#19
Nicholas A Wallace, Karl Münger
No abstract text is available yet for this article.
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29324843/beta-hpv38-oncoproteins-act-with-a-hit-and-run-mechanism-in-ultraviolet-radiation-induced-skin-carcinogenesis-in-mice
#20
Daniele Viarisio, Karin Müller-Decker, Rosita Accardi, Alexis Robitaille, Matthias Dürst, Katrin Beer, Lars Jansen, Christa Flechtenmacher, Matthias Bozza, Richard Harbottle, Catherine Voegele, Maude Ardin, Jiri Zavadil, Sandra Caldeira, Lutz Gissmann, Massimo Tommasino
Cutaneous beta human papillomavirus (HPV) types are suspected to be involved, together with ultraviolet (UV) radiation, in the development of non-melanoma skin cancer (NMSC). Studies in in vitro and in vivo experimental models have highlighted the transforming properties of beta HPV E6 and E7 oncoproteins. However, epidemiological findings indicate that beta HPV types may be required only at an initial stage of carcinogenesis, and may become dispensable after full establishment of NMSC. Here, we further investigate the potential role of beta HPVs in NMSC using a Cre-loxP-based transgenic (Tg) mouse model that expresses beta HPV38 E6 and E7 oncogenes in the basal layer of the skin epidermis and is highly susceptible to UV-induced carcinogenesis...
January 2018: PLoS Pathogens
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