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https://www.readbyqxmd.com/read/28918112/radiographic-and-clinical-comparison-of-pegged-and-keeled-glenoid-components-using-modern-cementing-techniques-midterm-results-of-a-prospective-randomized-study
#1
Christopher M Kilian, Cyrus M Press, Kevin M Smith, Daniel P O'Connor, Brent J Morris, Hussein A Elkousy, Gary M Gartsman, T Bradley Edwards
BACKGROUND: Glenoid component loosening remains a significant issue after anatomic shoulder arthroplasty. Pegged glenoid components have shown better lucency rates than keeled components in the short term; however, midterm to long-term results have not fully been determined. We previously reported early outcomes of the current randomized controlled group of patients, with higher glenoid lucency rates in those with a keeled glenoid. The purpose of this study was to evaluate the radiographic and clinical outcomes of these components at minimum 5-year follow-up...
September 13, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28916879/a-score-combining-baseline-neutrophilia-and-primary-tumor-suvpeak-measured-from-fdg-pet-is-associated-with-outcome-in-locally-advanced-cervical-cancer
#2
Antoine Schernberg, Sylvain Reuze, Fanny Orlhac, Irène Buvat, Laurent Dercle, Roger Sun, Elaine Limkin, Alexandre Escande, Christine Haie-Meder, Eric Deutsch, Cyrus Chargari, Charlotte Robert
PURPOSE: We investigated whether a score combining baseline neutrophilia and a PET biomarker could predict outcome in patients with locally advanced cervical cancer (LACC). METHODS: Patients homogeneously treated with definitive chemoradiation plus image-guided adaptive brachytherapy (IGABT) between 2006 and 2013 were analyzed retrospectively. We divided patients into two groups depending on the PET device used: a training set (TS) and a validation set (VS). Primary tumors were semi-automatically delineated on PET images, and 11 radiomics features were calculated (LIFEx software)...
September 15, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28915238/a-high-resolution-atlas-of-gene-expression-in-the-domestic-sheep-ovis-aries
#3
Emily L Clark, Stephen J Bush, Mary E B McCulloch, Iseabail L Farquhar, Rachel Young, Lucas Lefevre, Clare Pridans, Hiu Tsang, Chunlei Wu, Cyrus Afrasiabi, Mick Watson, C Bruce Whitelaw, Tom C Freeman, Kim M Summers, Alan L Archibald, David A Hume
Sheep are a key source of meat, milk and fibre for the global livestock sector, and an important biomedical model. Global analysis of gene expression across multiple tissues has aided genome annotation and supported functional annotation of mammalian genes. We present a large-scale RNA-Seq dataset representing all the major organ systems from adult sheep and from several juvenile, neonatal and prenatal developmental time points. The Ovis aries reference genome (Oar v3.1) includes 27,504 genes (20,921 protein coding), of which 25,350 (19,921 protein coding) had detectable expression in at least one tissue in the sheep gene expression atlas dataset...
September 15, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28914125/mobilizing-cross-sector-community-partnerships-to-address-the-needs-of-criminal-justice-involved-older-adults-a-framework-for-action
#4
Lia Metzger, Cyrus Ahalt, Margot Kushel, Alissa Riker, Brie Williams
Purpose The rapidly increasing number of older adults cycling through local criminal justice systems (jails, probation, and parole) suggests a need for greater collaboration among a diverse group of local stakeholders including professionals from healthcare delivery, public health, and criminal justice and directly affected individuals, their families, and advocates. The purpose of this paper is to develop a framework that local communities can use to understand and begin to address the needs of criminal justice-involved older adults...
September 11, 2017: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/28914123/advancing-evidence-based-interventions-at-the-intersection-of-criminal-justice-and-health
#5
Cyrus Ahalt, Brie Williams
No abstract text is available yet for this article.
September 11, 2017: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/28914119/building-on-mental-health-training-for-law-enforcement-strengthening-community-partnerships
#6
Jorien Campbell, Cyrus Ahalt, Randall Hagar, William Arroyo
Purpose The purpose of this paper is to describe the current state of law enforcement training related to the high number of interactions with persons with mental illness, and to recommend next steps in preparing law enforcement to effectively meet this challenge. Design/methodology/approach The authors reviewed the current literature on relevant law enforcement training programs, focusing primarily on crisis intervention team (CIT) training, and used the case example of California to identify opportunities to improve and enhance law enforcement preparedness for the challenge of responding to persons with mental illness...
September 11, 2017: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/28912118/topically-applied-carvedilol-attenuates-solar-ultraviolet-radiation-induced-skin-carcinogenesis
#7
Kevin M Huang, Sherry Liang, Steven Yeung, Etuajie Oiyemhonlan, Kristan H Cleveland, Cyrus Parsa, Robert Orlando, Frank L Meyskens, Bradley T Andresen, Ying Huang
In previous studies, the β-blocker carvedilol inhibited EGF-induced epidermal cell transformation and chemical carcinogen-induced mouse skin hyperplasia. As exposure to ultraviolet (UV) radiation leads to skin cancer, the present study examined whether carvedilol can prevent UV-induced carcinogenesis. Carvedilol absorbs UV like a sunscreen; thus, to separate pharmacological from sunscreen effects, 4-hydroxycarbazole (4-OHC), which absorbs UV to the same degree as carvedilol, served as control. JB6 P(+) cells, an established epidermal model for studying tumor promotion, were used for evaluating the effect of carvedilol on UV-induced neoplastic transformation...
August 15, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28911164/response-to-letter-genetics-and-vitamin-d-supplementation-in-pregnancy
#8
Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper
No abstract text is available yet for this article.
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28905727/-teach-to-goal-to-better-assess-informed-consent-comprehension-among-incarcerated-clinical-research-participants
#9
Cyrus Ahalt, Rebecca Sudore, Marielle Bolano, Lia Metzger, Anna M Darby, Brie Williams
Correctional health research requires important safeguards to ensure that research participation is ethically conducted. In addition to having disproportionately low educational attainment and low literacy, incarcerated people suffer from health-related conditions that can affect cognition (e.g., traumatic brain injury, substance use disorders, mental illness). Yet modified informed consent processes that assess participants' comprehension of the risks and benefits of participation are not required by relevant federal guidelines...
September 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28899987/heart-failure-related-hyperphosphorylation-in-the-cardiac-troponin-i-c-terminus-has-divergent-effects-on-cardiac-function-in-vivo
#10
Yuejin Li, Guangshuo Zhu, Nazareno Paolocci, Pingbo Zhang, Cyrus Takahashi, Nazli Okumus, Amir Heravi, Gizem Keceli, Genaro Ramirez-Correa, David A Kass, Anne M Murphy
BACKGROUND: In human heart failure, Ser199 (equivalent to Ser200 in mouse) of cTnI (cardiac troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that it enhances myofilament calcium sensitivity and alters calpain-mediated cTnI proteolysis. However, how its hyperphosphorylation affects cardiac function in vivo remains unknown. METHODS AND RESULTS: To address the question, 2 transgenic mouse models were generated: a phospho-mimetic cTnIS200D and a phospho-silenced cTnIS200A, each driven by the cardiomyocyte-specific α-myosin heavy chain promoter...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28898650/wilhelm-hofmeister-and-the-foundations-of-plant-science
#11
EDITORIAL
Cyrus Martin
On January 12(th) 1877, the Grim Reaper visited Wilhelm Hofmeister (Figure 1) for the last time. Having recently witnessed the death of a wife, two daughters, and two sons (only two of his nine children survived him), the German botanist, perhaps succumbing to the weight of his own grief, suffered a series of strokes and then promptly died at the age of 52 in Lindenau, Germany. He has since faded into the dusty annals of 19(th) century botany, his contributions to our knowledge about plants, how they come into being, develop and interact with their environment, mostly forgotten...
September 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28891935/alteration-of-mammary-gland-development-and-gene-expression-by-in-utero-exposure-to-cadmium
#12
Daniela A Parodi, Morgan Greenfield, Claire Evans, Anna Chichura, Alexandra Alpaugh, James Williams, Kedra C Cyrus, Mary Beth Martin
Environmental exposure to estrogens and estrogen like contaminants during early development is thought to contribute to the risk of developing breast cancer primarily due to an early onset of puberty; however, exposure during key developing windows may also influence the risk of developing the disease. The goal of this study was to ask whether in utero exposure to the metalloestrogen cadmium alters mammary gland development due to acceleration of puberty onset or to an effect on early development of the mammary gland...
September 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28890828/radiation-induced-gastroparesis-case-report-and-literature-review
#13
Pierre Annede, Caroline Prieux-Klotz, Thomas Dubergé, Cyrus Chargari, Olivier Gisserot, Jean-Pierre de Jaureguiberry
Radiation induced gastroparesis as well as the other autonomic nervous system radiation induced neuropathies are poorly described in the literature. A case of gastroparesis associated with phrenic and recurrent laryngeal nerves paralysis was observed in a 69-year old patient. She was already treated two times by rachis radiotherapy in a context of breast cancer with bone metastases. Anatomical and chronological correlation of lesions, concomitant nerve damage in the radiation fields and elimination of the main differential diagnoses allowed us to link this case of gastroparesis with the background of radiotherapy...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28889081/distinct-solubility-and-cytotoxicity-regimes-of-paclitaxel-loaded-cationic-liposomes-at-low-and-high-drug-content-revealed-by-kinetic-phase-behavior-and-cancer-cell-viability-studies
#14
Victoria M Steffes, Meena M Murali, Yoonsang Park, Bretton J Fletcher, Kai K Ewert, Cyrus R Safinya
Lipid-based particles are used worldwide in clinical trials as carriers of hydrophobic paclitaxel (PTXL) for cancer chemotherapy, albeit with little improvement over the standard-of-care. Improving efficacy requires an understanding of intramembrane interactions between PTXL and lipids to enhance PTXL solubilization and suppress PTXL phase separation into crystals. We studied the solubility of PTXL in cationic liposomes (CLs) composed of positively charged 2,3-dioleyloxypropyltrimethylammonium chloride (DOTAP) and neutral 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) as a function of PTXL membrane content and its relation to efficacy...
August 17, 2017: Biomaterials
https://www.readbyqxmd.com/read/28884003/the-transformation-of-the-nuclear-nanoarchitecture-in-human-field-carcinogenesis
#15
REVIEW
Greta M Bauer, Yolanda Stypula-Cyrus, Hariharan Subramanian, Lusik Cherkezyan, Parvathi Viswanathan, Di Zhang, Radha Iyengar, Saurabh Bagalkar, Justin Derbas, Taylor Graff, Scott Gladstein, Luay M Almassalha, John E Chandler, Hemant K Roy, Vadim Backman
Morphological alterations of the nuclear texture are a hallmark of carcinogenesis. At later stages of disease, these changes are well characterized and detectable by light microscopy. Evidence suggests that similar albeit nanoscopic alterations develop at the predysplastic stages of carcinogenesis. Using the novel optical technique partial wave spectroscopic microscopy, we identified profound changes in the nanoscale chromatin topology in microscopically normal tissue as a common event in the field carcinogenesis of many cancers...
August 2017: Future Science OA
https://www.readbyqxmd.com/read/28882352/adult-spinal-deformity-national-trends-in-the-presentation-treatment-and-perioperative-outcomes-from-2003-to-2010
#16
Peter G Passias, Cyrus M Jalai, Nancy Worley, Shaleen Vira, Bryan Marascalchi, Shearwood McClelland, Virginie Lafage, Thomas J Errico
STUDY DESIGN: Retrospective review of a prospective database. OBJECTIVES: To investigate adult spinal deformity (ASD) surgery outcome trends on a nationwide scale using the Nationwide Inpatient Sample (NIS) from 2003 to 2010. METHODS: ASD patients ≥25 years from 2003 to 2010 in the NIS undergoing anterior, posterior, or combined surgical approaches were included. Fractures, 9+ levels fused, or any cancer were excluded. Patient demographics, hospital data, and procedure-related complications were evaluated...
September 2017: Spine Deformity
https://www.readbyqxmd.com/read/28882309/expression-and-isolation-of-recombinant-tau
#17
Rebecca L Best, Peter J Chung, Sarah J Benbow, April Savage, Nichole E LaPointe, Cyrus R Safinya, Stuart C Feinstein
In this chapter, we describe methods for the purification of both untagged and polyhistidine-tagged tau protein. These protocols utilize a bacterial expression system to produce the tau isoform of interest, followed by heat treatment and column chromatography to separate tau from impurities. These techniques yield a biochemically pure protein with which to pursue any number of questions regarding the mechanisms of tau action.
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28882300/synchrotron-small-angle-x-ray-scattering-and-electron-microscopy-characterization-of-structures-and-forces-in-microtubule-tau-mixtures
#18
Peter J Chung, Chaeyeon Song, Herbert P Miller, Youli Li, Uri Raviv, Myung Chul Choi, Leslie Wilson, Stuart C Feinstein, Cyrus R Safinya
Tau, a neuronal protein known to bind to microtubules and thereby regulate microtubule dynamic instability, has been shown recently to not only undergo conformational transitions on the microtubule surface as a function of increasing microtubule coverage density (i.e., with increasing molar ratio of Tau to tubulin dimers) but also to mediate higher-order microtubule architectures, mimicking fascicles of microtubules found in the axon initial segment. These discoveries would not have been possible without fine structure characterization of microtubules, with and without applied osmotic pressure through the use of depletants...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28874563/epigenetic-control-via-allosteric-regulation-of-mammalian-protein-arginine-methyltransferases
#19
Kanishk Jain, Cyrus Y Jin, Steven G Clarke
Arginine methylation on histones is a central player in epigenetics and in gene activation and repression. Protein arginine methyltransferase (PRMT) activity has been implicated in stem cell pluripotency, cancer metastasis, and tumorigenesis. The expression of one of the nine mammalian PRMTs, PRMT5, affects the levels of symmetric dimethylarginine (SDMA) at Arg-3 on histone H4, leading to the repression of genes which are related to disease progression in lymphoma and leukemia. Another PRMT, PRMT7, also affects SDMA levels at the same site despite its unique monomethylating activity and the lack of any evidence for PRMT7-catalyzed histone H4 Arg-3 methylation...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28874526/identification-of-individuals-by-trait-prediction-using-whole-genome-sequencing-data
#20
Christoph Lippert, Riccardo Sabatini, M Cyrus Maher, Eun Yong Kang, Seunghak Lee, Okan Arikan, Alena Harley, Axel Bernal, Peter Garst, Victor Lavrenko, Ken Yocum, Theodore Wong, Mingfu Zhu, Wen-Yun Yang, Chris Chang, Tim Lu, Charlie W H Lee, Barry Hicks, Smriti Ramakrishnan, Haibao Tang, Chao Xie, Jason Piper, Suzanne Brewerton, Yaron Turpaz, Amalio Telenti, Rhonda K Roby, Franz J Och, J Craig Venter
Prediction of human physical traits and demographic information from genomic data challenges privacy and data deidentification in personalized medicine. To explore the current capabilities of phenotype-based genomic identification, we applied whole-genome sequencing, detailed phenotyping, and statistical modeling to predict biometric traits in a cohort of 1,061 participants of diverse ancestry. Individually, for a large fraction of the traits, their predictive accuracy beyond ancestry and demographic information is limited...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
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