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https://www.readbyqxmd.com/read/28625816/a-prospective-multicenter-study-evaluating-learning-curves-and-competence-in-endoscopic-ultrasound-and-endoscopic-retrograde-cholangiopancreatography-among-advanced-endoscopy-trainees-the-rapid-assessment-of-trainee-endoscopy-skills-rates-study
#1
Sachin Wani, Rajesh Keswani, Matt Hall, Samuel Han, Meer Akbar Ali, Brian Brauer, Linda Carlin, Amitabh Chak, Dan Collins, Gregory A Cote, David L Diehl, Christopher J DiMaio, Andrew Dries, Ihab El-Hajj, Swan Ellert, Kimberley Fairley, Ashley Faulx, Larissa Fujii-Lau, Srinivas Gaddam, Seng-Ian Gan, Jonathan P Gaspar, Chitiki Gautamy, Stuart Gordon, Cynthia Harris, Sarah Hyder, Ross Jones, Stephen Kim, Srinadh Komanduri, Ryan Law, Linda Lee, Rawad Mounzer, Daniel Mullady, V Raman Muthusamy, Mojtaba Olyaee, Patrick Pfau, Shreyas Saligram, Cyrus Piraka, Amit Rastogi, Laura Rosenkranz, Fadi Rzouq, Aditi Saxena, Raj J Shah, Violette C Simon, Aaron Small, Jayaprakash Sreenarasimhaiah, Andrew Walker, Andrew Y Wang, Rabindra R Watson, Robert H Wilson, Patrick Yachimski, Dennis Yang, Steven Edmundowicz, Dayna S Early
BACKGROUND AND AIMS: Based on the Next Accreditation System, trainee assessment should occur on a continuous basis with individualized feedback. We aimed to validate endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) learning curves among advanced endoscopy trainees (AETs) using a large national sample of training programs and to develop a centralized database that allows assessment of performance in relation to peers. METHODS: ASGE recognized training programs were invited to participate and AETs were graded on ERCP and EUS exams using a validated competency assessment tool that assesses technical and cognitive competence in a continuous fashion...
June 15, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28623255/quantitative-modelling-of-hip-fracture-trends-in-14-european-countries-testing-variations-of-a-shared-reversal-over-time
#2
Raquel Lucas, Ana Martins, Milton Severo, Poliana Silva, Teresa Monjardino, Ana Rita Gaio, Cyrus Cooper, Henrique Barros
Qualitative similarities between hip fracture trends in different countries suggests variations of the same epidemic. We tested a single statistical shape to describe time trends in Europe, while allowing for country-level variability. Using data from 14 countries, we modelled incidence rates over time using linear mixed-effects models, including the fixed effects of calendar year and age. Random effects were tested to quantify country-level variability in background rates, timing of trend reversal and tempo of reversal...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619752/the-met-axl-fgfr-inhibitor-s49076-impairs-aurora-b-activity-and-improves-the-antitumor-efficacy-of-radiotherapy
#3
Céline Clémenson, Cyrus Chargari, Winchygn Liu, Michele Mondini, Charles Ferté, Mike F Burbridge, Valérie Cattan, Anne Jacquet-Bescond, Eric Deutsch
Several therapeutic agents targeting HGF/MET signaling are under clinical development as single agents or in combination, notably with anti-EGFR therapies in non-small cell lung cancer (NSCLC). However, despite increasing data supporting a link between MET, irradiation and cancer progression, no data regarding the combination of MET-targeting agents and radiotherapy are available from the clinic. S49076 is an oral ATP-competitive inhibitor of MET, AXL and FGFR1-3 receptors that is currently in phase I/II clinical trials in combination with gefinitib in NSCLC patients whose tumors show resistance to EGFR inhibitors...
June 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28619715/liquefied-gas-electrolytes-for-electrochemical-energy-storage-devices
#4
Cyrus S Rustomji, Yangyuchen Yang, Tae Kyoung Kim, Jimmy Mac, Young Jin Kim, Elizabeth Caldwell, Hyeseung Chung, Y Shirley Meng
Electrochemical capacitors and Li-ion batteries have seen little change in their electrolyte chemistry since their commercialization which has limited improvements in device performance. Combining superior physical and chemical properties and a high dielectric-fluidity factor, the use of electrolytes based on solvent systems which exclusively use components which are typically gaseous under standard conditions show a wide potential window of stability and excellent performance over an extended temperature range...
June 15, 2017: Science
https://www.readbyqxmd.com/read/28602747/association-of-a-neuronal-nitric-oxide-synthase-gene-polymorphism-with-levodopa-induced-dyskinesia-in-parkinson-s-disease
#5
Bruno Lopes Santos-Lobato, Vanderci Borges, Henrique Ballalai Ferraz, Ignacio Fernandez Mata, Cyrus P Zabetian, Vitor Tumas
BACKGROUND: Levodopa-induced dyskinesia (LID) is a common complication of advanced Parkinson's disease (PD). PD physiopathology is associated with dopaminergic and non-dopaminergic pathways, including the nitric oxide system. The present study aims to examine the association of a neuronal nitric oxide synthase gene (NOS1) single nucleotide polymorphism (rs2682826) with LID in PD patients. METHODS AND RESULTS: We studied 186 PD patients using levodopa. The presence of LID was defined as a MDS-UPDRS Part IV score ≥1 on item 4...
June 8, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28600656/specialist-endoscopists-are-associated-with-a-decreased-risk-of-incomplete-polyp-resection-during-endoscopic-mucosal-resection-in-the-colon
#6
Anna Tavakkoli, Ryan J Law, Aarti O Bedi, Anoop Prabhu, Tadd Hiatt, Michelle A Anderson, Erik J Wamsteker, B Joseph Elmunzer, Cyrus R Piraka, James M Scheiman, Grace H Elta, Richard S Kwon
BACKGROUND: Endoscopic experience is known to correlate with outcomes of endoscopic mucosal resection (EMR), particularly complete resection of the polyp tissue. Whether specialist endoscopists can protect against incomplete polypectomy in the setting of known risk factors for incomplete resection (IR) is unknown. AIMS: We aimed to characterize how specialist endoscopists may help to mitigate the risk of IR of large sessile polyps. METHODS: This is a retrospective cohort study of patients who underwent EMR at the University of Michigan from January 1, 2006, to November 15, 2015...
June 9, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28594508/lateral-ankle-instability-and-peroneal-tendon-pathology
#7
Michael Isiah Sandlin, Cyrus E Taghavi, Timothy P Charlton, Richard D Ferkel
Surgeons should understand the anatomic, vascular, biomechanical, and predisposing factors related to lateral ankle instability and peroneal tendon injuries, including peroneal tendinitis and tenosynovitis, peroneal tendon tears and ruptures, as well as peroneal tendon subluxation and dislocation. Surgeons should understand the treatment options and recommendations for patients who have lateral ankle instability and peroneal tendon injuries from the perspective of a sports medicine foot and ankle specialist...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28594507/management-of-osteochondral-lesions-of-the-talus
#8
Michael Isiah Sandlin, Timothy P Charlton, Cyrus E Taghavi, Eric Giza
Management strategies for symptomatic osteochondral lesions of the talus are primarily surgical. Treatment options for symptomatic osteochondral lesions of the talus most commonly include bone marrow stimulation techniques, osteochondral autograft transplantation, osteochondral allograft transplantation, autologous chondrocyte implantation, matrix-induced autologous chondrocyte implantation, and particulated juvenile articular cartilage. The selection of the most appropriate treatment option should be based on the specifics of a talar lesion, in particular, lesion size...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28594506/high-risk-stress-fractures-in-elite-athletes
#9
Michael Isiah Sandlin, Andrew J Rosenbaum, Cyrus E Taghavi, Timothy P Charlton, Martin J O'Malley
Surgeons should understand common factors that predispose high-level athletes to stress injuries as well as the importance of vitamin D and specifics related to vascular supply, location of injury, biomechanics, and susceptibility factors in high-level athletes who have stress injuries. Surgeons should be aware of diagnostic- and management-based recommendations for and the outcomes of anterior tibia, medial malleolus, tarsal navicular, and proximal fifth metatarsal stress fractures in professional athletes...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28594505/lisfranc-injuries-in-the-elite-athlete
#10
Michael Isiah Sandlin, Cyrus E Taghavi, Timothy P Charlton, Robert B Anderson
The management of sports-related Lisfranc injuries is optimized by a detailed understanding of the relevant anatomy, mechanisms of injury, clinical diagnostic maneuvers, imaging, and treatment options for patients with this disabling injury. A lower energy ligamentous variant Lisfranc injury, which was first observed in professional football players, has recently been described. The treatment options for patients with a Lisfranc injury include nonsurgical management, open reduction and internal fixation, suture-button fixation techniques, and arthrodesis...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28594504/achilles-tendon-rupture-in-elite-athletes
#11
Michael Isiah Sandlin, Cyrus E Taghavi, Timothy P Charlton
The management of acute Achilles tendon rupture in elite athletes is a current area of clinical controversy. Recent studies have reported near-equivocal outcomes in patients who undergo either nonsurgical or surgical treatment of Achilles tendon rupture; however, similar functional outcomes may not be observed in elite athletes who are at the highest levels of athletic performance and undergo nonsurgical or surgical treatment of Achilles tendon rupture. Surgeons should understand the risks and benefits of nonsurgical and surgical management of acute Achilles tendon rupture...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28594486/challenges-and-controversies-of-foot-and-ankle-trauma
#12
Cyrus E Taghavi, Michael Isiah Sandlin, David B Thordarson
Traumatic injury to the foot and ankle can result in long-term disability, which may have substantial negative implications on a patient's functional outcomes and quality of life. The diagnosis and appropriate management of these challenging injuries are not always agreed on or straightforward. In particular, the appropriate diagnosis and management of distal tibiofibular syndesmotic injuries as well as the surgical approach and role of primary subtalar arthrodesis for intra-articular calcaneal fractures are controversial...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28593652/pupil-size-as-a-measure-of-within-task-learning
#13
Cyrus K Foroughi, Ciara Sibley, Joseph T Coyne
Pupillometry is commonly used in research to determine how much mental effort an individual is exerting while completing tasks. Traditionally, larger pupils are associated with increased mental effort when completing more difficult tasks. However, little research has investigated how pupils change as individuals learn a new task. In theory, as one repeatedly completes a task, the task demands should reduce, reliance on working memory should decrease, and the task should become more automatic. This should translate to faster completion times and smaller peak pupil dilations...
June 7, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28589692/a-gatekeeping-procedure-to-test-a-primary-and-a-secondary-endpoint-in-a-group-sequential-design-with-multiple-interim-looks
#14
Ajit C Tamhane, Jiangtao Gou, Christopher Jennison, Cyrus R Mehta, Teresa Curto
Glimm et al. (2010) and Tamhane et al. (2010) studied the problem of testing a primary and a secondary endpoint, subject to a gatekeeping constraint, using a group sequential design (GSD) with K=2 looks. In this article, we greatly extend the previous results to multiple (K>2) looks. If the familywise error rate (FWER) is to be controlled at a preassigned α level then it is clear that the primary boundary must be of level α. We show under what conditions one α-level primary boundary is uniformly more powerful than another...
June 6, 2017: Biometrics
https://www.readbyqxmd.com/read/28589303/three-types-of-sagittal-alignment-regarding-compensation-in-asymptomatic-adults-the-contribution-of-the-spine-and-lower-limbs
#15
Hongda Bao, Renaud Lafage, Barthelemy Liabaud, Jonathan Elysée, Bassel G Diebo, Gregory Poorman, Cyrus Jalai, Peter Passias, Aaron Buckland, Shay Bess, Thomas Errico, Lawrence G Lenke, Munish Gupta, Han Jo Kim, Frank Schwab, Virginie Lafage
PURPOSE: A comprehensive understanding of normative sagittal profile is necessary for adult spinal deformity. Roussouly described four sagittal alignment types based on sacral slope, lumbar lordosis, and location of lumbar apex. However, the lower limb, a newly described component of spinal malalignment compensation, is missing from this classification. This study aims to propose a full-body sagittal profile classification in an asymptomatic population based on full-body imaging. METHODS: This is a retrospective analysis of a prospective single-center study of 116 asymptomatic volunteers...
June 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28578992/the-impact-of-fragility-fracture-and-approaches-to-osteoporosis-risk-assessment-worldwide
#16
Elizabeth M Curtis, Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper
Osteoporosis constitutes a major public health problem, through its association with age-related fractures, particularly of the hip, vertebrae, distal forearm and humerus. Substantial geographic variation has been noted in the incidence of osteoporotic fractures worldwide, with Western populations (North America, Europe and Oceania), reporting increases in hip fracture throughout the second half of the 20th century, with a stabilisation or decline in the last two decades. In developing populations however, particularly in Asia, the rates of osteoporotic fracture appears to be increasing...
April 26, 2017: International Journal of Orthopaedic and Trauma Nursing
https://www.readbyqxmd.com/read/28575457/characterizing-adult-cervical-deformity-and-disability-based-on-existing-cervical-and-adult-deformity-classification-schemes-at-presentation-and-following-correction
#17
Peter G Passias, Cyrus M Jalai, Justin S Smith, Virginie Lafage, Bassel G Diebo, Themistocles Protopsaltis, Gregory Poorman, Ubaraman Ramchandran, Hay Bess, Christopher I Shaffrey, Christopher P Ames, Frank Schwab
BACKGROUND: Adult cervical deformity (ACD) classifications have not been implemented in a prospective ACD population and in conjunction with adult spinal deformity (ASD) classifications. OBJECTIVE: To characterize cervical deformity type and malalignment with 2 classifications (Ames-ACD and Schwab-ASD). METHODS: Retrospective review of a prospective multicenter ACD database. Inclusion: patients ≥18 yr with pre- and postoperative radiographs...
May 30, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28575224/response-to-antenatal-cholecalciferol-supplementation-is-associated-with-common-vitamin-d-related-genetic-variants
#18
Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper, Stefania D'Angelo, Elizabeth M Curtis, Sarah R Crozier, Sheila J Barton, Sian M Robinson, Keith M Godfrey, Nikki J Graham, John W Holloway, Nicholas J Bishop, Stephen Kennedy, Aris T Papageorghiou, Inez Schoenmakers, Robert Fraser, Saurabh V Gandhi, Ann Prentice, Hazel M Inskip, M Kassim Javaid
Context: Single nucleotide polymorphisms (SNP) in genes related to vitamin D metabolism have been associated with serum 25-hydroxyvitamin D [25(OH)D] concentration, but these relationships have not been examined following antenatal cholecalciferol supplementation. Objective: To determine whether SNPs in DHCR7, CYP2R1, CYP24A1 and GC are associated with the response to gestational cholecalciferol supplementation. Design: Within-randomization-group analysis of the MAVIDOS trial of antenatal cholecalciferol supplementation...
May 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28574816/prediction-of-cervical-cancer-recurrence-using-textural-features-extracted-from-18f-fdg-pet-images-acquired-with-different-scanners
#19
Sylvain Reuzé, Fanny Orlhac, Cyrus Chargari, Christophe Nioche, Elaine Limkin, François Riet, Alexandre Escande, Christine Haie-Meder, Laurent Dercle, Sébastien Gouy, Irène Buvat, Eric Deutsch, Charlotte Robert
OBJECTIVES: To identify an imaging signature predicting local recurrence for locally advanced cervical cancer (LACC) treated by chemoradiation and brachytherapy from baseline 18F-FDG PET images, and to evaluate the possibility of gathering images from two different PET scanners in a radiomic study. METHODS: 118 patients were included retrospectively. Two groups (G1, G2) were defined according to the PET scanner used for image acquisition. Eleven radiomic features were extracted from delineated cervical tumors to evaluate: (i) the predictive value of features for local recurrence of LACC, (ii) their reproducibility as a function of the scanner within a hepatic reference volume, (iii) the impact of voxel size on feature values...
May 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28574140/hybrid-20-23-g-pars-plana-vitrectomy-in-endophthalmitis-and-trauma-a-strategic-approach
#20
Daraius Shroff, Priyanka Gupta, Charu Gupta, Neelam Atri, Ranjan Dutta, Cyrus Shroff
PURPOSE: To assess the safety and efficacy of hybrid vitreous surgery combining active 23-G ports with a sutured 20-G 6-mm infusion cannula for performing vitrectomy in endophthalmitis and trauma. METHODS: This is a retrospective analysis of 10 eyes with endophthalmitis and 10 eyes with trauma requiring vitreous surgery, having corneal clarity suitable for vitrectomy and best-corrected visual acuity (BCVA) greater than or equal to light perception. All patients underwent hybrid 20/23-G vitrectomy...
May 25, 2017: European Journal of Ophthalmology
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