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https://www.readbyqxmd.com/read/29776684/a-hybrid-technique-to-address-exposure-keratopathy-secondary-to-facial-nerve-paresis-a-combination-of-a-lateral-tarsorrhaphy-and-lateral-wedge-resection
#1
Roxana Fu, Nicholas Moore, Taha Z Shipchandler, Jonathan Y Ting, Travis Tollefson, Cyrus Rabbani, Meena Moorthy, William R Nunery, H B Harold Lee
PURPOSE: To present the results of treating combined lower eyelid laxity, retraction and midface descent secondary to facial nerve weakness with a hybrid surgical procedure. MATERIALS AND METHODS: A retrospective analysis of patients from January 2015 to January 2017 who underwent a hybrid surgical technique for the treatment of corneal exposure secondary to facial nerve paresis with a single surgeon was performed. Age, gender, and presence of exposure symptoms were recorded pre-operatively...
May 9, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29773572/hemostatic-efficacy-of-pathogen-inactivated-versus-untreated-platelets-a-randomized-controlled-trial
#2
Pieter F van der Meer, Paula F Ypma, Nan van Geloven, Joost A van Hilten, Rinie J van Wordragen-Vlaswinkel, Okke Eissen, Jaap J Zwaginga, MIchael Trus, Erik A M Beckers, Peter Te Boekhorst, Alan Tinmouth, Yulia Lin, Cyrus Hsia, David Lee, Philip J Norris, Raymond P Goodrich, Anneke Brand, Tor Hervig, Nancy M Heddle, Johanna G van der Bom, Jean-Louis H Kerkhoffs
Pathogen inactivation of platelet concentrates reduces the risk of blood-borne infections. However, its effect on platelet function and hemostatic efficacy of transfusion is unclear. We conducted a randomized noninferiority trial comparing the efficacy of pathogen inactivated platelets using riboflavin and ultraviolet B illumination technology (intervention) compared to standard plasma-stored platelets (control) for the prevention of bleeding in patients with hematologic malignancies and thrombocytopenia. The primary outcome parameter was the proportion of transfusion treatment periods in which the patient had grade 2 or higher bleeding as defined by World Health Organization (WHO) criteria...
May 17, 2018: Blood
https://www.readbyqxmd.com/read/29769023/risk-factors-for-incident-falls-in-older-men-and-women-the-english-longitudinal-study-of-ageing
#3
Catharine R Gale, Leo D Westbury, Cyrus Cooper, Elaine M Dennison
BACKGROUND: Falls are a major cause of disability and death in older people, particularly women. Cross-sectional surveys suggest that some risk factors associated with a history of falls may be sex-specific, but whether risk factors for incident falls differ between the sexes is unclear. We investigated whether risk factors for incident falls differ between men and women. METHODS: Participants were 3298 people aged ≥60 who took part in the Waves 4-6 surveys of the English Longitudinal Study of Ageing...
May 16, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29767745/preconception-maternal-iodine-status-is-positively-associated-with-iq-but-not-with-measures-of-executive-function-in-childhood
#4
Sian M Robinson, Sarah R Crozier, Elizabeth A Miles, Catharine R Gale, Philip C Calder, Cyrus Cooper, Hazel M Inskip, Keith M Godfrey
Background: Adverse effects of severe maternal iodine deficiency in pregnancy on fetal brain development are well-established, but the effects of milder deficiency are uncertain. Most studies examine iodine status in pregnancy; less is known about iodine nutrition before conception. Objective: We examined relations between maternal preconception iodine status and offspring cognitive function, within a prospective mother-offspring cohort. Methods: Maternal iodine status was assessed through the use of the ratio of iodine:creatinine concentrations (I/Cr) in spot urine samples [median (IQR) period before conception 3...
May 15, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29753523/testicular-transposition-in-children-undergoing-brachytherapy-for-bladder-and-or-prostate-rhabdomyosarcoma
#5
Guenolee de Lambert, Cyrus Chargari, Véronique Minard-Colin, Christine Haie-Meder, Florent Guérin, Hélène Martelli
BACKGROUND/PURPOSE: Fertility preservation is a major goal in treatment of children with cancer. We describe a new technique of testicular transposition (TT) in patients treated with pulse-dose-rate (PDR) brachytherapy as part of the multimodal conservative treatment of bladder neck and/or prostate rhabdomyosarcoma (BP RMS). METHODS: Medical records of consecutive patients treated between September 2016 and August 2017 were studied. These patients underwent a TT performed during BP RMS surgery by the same suprapubic incision...
April 13, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29751966/outcomes-in-nursing-home-patients-with-traumatic-brain-injury
#6
Stephanie N Lueckel, Cyrus M Kosar, Joan M Teno, Sean F Monaghan, Daithi S Heffernan, William G Cioffi, Kali S Thomas
BACKGROUND: Traumatic brain injury is a leading cause of death and disability in the United States. In survivors, traumatic brain injury remains a leading contributor to long-term disability and results in many patients being admitted to skilled nursing facilities for postacute care. Despite this very large population of traumatic brain injury patients, very little is known about the long-term outcomes of traumatic brain injury survivors, including rates of discharge to home or risk of death in long-term nursing facilities...
May 9, 2018: Surgery
https://www.readbyqxmd.com/read/29744648/the-eden-hybbinette-procedure-is-one-hundred-years-old-a-historical-view-of-the-concept-and-its-evolutions
#7
Guillaume Villatte, Sally Spurr, Cyrus Broden, Antoine Martins, Roger Emery, Peter Reilly
INTRODUCTION: One hundred years ago, before Bankart, Latarjet or Bristow, Eden and Hybbinette developed a procedure to treat anterior shoulder instability and currently, this eponymous term is known by every shoulder surgeon. The purpose of this review is to summarise the historical "Eden-Hybbinette" procedure and its evolutions during the last century and discuss results. METHOD: On the centenary of the first publication on the "Eden-Hybbinette procedure", a search was conducted on Medline, Google Scholar and in the grey literature, to find its initial concept and description, and the evolutions...
May 9, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29741284/novel-approach-to-estimate-osteoarthritis-progression-use-of-the-reliable-change-index-in-the-evaluation-of-joint-space-loss
#8
Camille Parsons, Andrew Judge, Kirsten Leyland, Olivier Bruyère, Florence Petit Dop, Roland Chapurlat, Jean-Yves Reginster, Mark Edwards, Elaine Dennison, Cyrus Cooper, Hazel Inskip
OBJECTIVE: Osteoarthritis-related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change (RC) index determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RC index as a novel approach to estimating osteoarthritis progression. METHODS: Data from 167 men and 392 women with knee osteoarthritis (diagnosed using the ACR criteria) randomised to the placebo arm of the 3-year Strontium Ranelate Efficacy in Knee Osteoarthritis triAl (SEKOIA) and assessed annually...
May 9, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29737202/health-care-costs-hospital-admissions-and-glycemic-control-using-a-standalone-real-time-continuous-glucose-monitoring-system-in-commercially-insured-patients-with-type-1-diabetes
#9
Max Gill, Cyrus Zhu, Mona Shah, Harmeet Chhabra
BACKGROUND: Studies comparing standalone real-time continuous glucose monitoring (rtCGM) to self-monitoring of blood glucose (SMBG) in patients with type 1 diabetes mellitus (T1DM) have found that rtCGM is associated with lower glycated hemoglobin (A1C) levels, yet does not increase the risk of severe hypoglycemia. However, little is known about the relationship between rtCGM and health care costs and utilization. The objective of this study was to compare health care spending, hospital admissions, and A1C levels of patients using rtCGM to that of patients not using rtCGM...
May 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29734952/arachidonic-acid-and-dha-status-in-pregnant-women-is-not-associated-with-cognitive-performance-of-their-children-at-4-or-6-7-years
#10
Sarah R Crozier, Charlene M Sibbons, Helena L Fisk, Keith M Godfrey, Philip C Calder, Catharine R Gale, Sian M Robinson, Hazel M Inskip, Janis Baird, Nicholas C Harvey, Cyrus Cooper, Graham C Burdge
Arachidonic acid (ARA) and DHA, supplied primarily from the mother, are required for early development of the central nervous system. Thus, variations in maternal ARA or DHA status may modify neurocognitive development. We investigated the relationship between maternal ARA and DHA status in early (11·7 weeks) or late (34·5 weeks) pregnancy on neurocognitive function at the age of 4 years or 6-7 years in 724 mother-child pairs from the Southampton Women's Survey cohort. Plasma phosphatidylcholine fatty acid composition was measured in early and late pregnancy...
May 8, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29731989/statin-use-and-survival-in-patients-with-metastatic-castration-resistant-prostate-cancer-treated-with-abiraterone-or-enzalutamide-after-docetaxel-failure-the-international-retrospective-observational-staben-study
#11
Jacob A Gordon, Carlo Buonerba, Gregory Pond, Daniel Crona, Silke Gillessen, Giuseppe Lucarelli, Sabrina Rossetti, Tanya Dorff, Salvatore Artale, Jennifer A Locke, Davide Bosso, Matthew Ivan Milowsky, Mira Sofie Witek, Michele Battaglia, Sandro Pignata, Cyrus Cherhroudi, Michael E Cox, Pietro De Placido, Dario Ribera, Aurelius Omlin, Gaetano Buonocore, Kim Chi, Christian Kollmannsberger, Daniel Khalaf, Gaetano Facchini, Guru Sonpavde, Sabino De Placido, Bernhard J Eigl, Giuseppe Di Lorenzo
Background: Statins may potentiate the effects of anti-hormonal agents for metastatic castration-resistant prostate cancer (mCRPC) through further disruption of essential steroidogenic processes. We investigated the effects of statin use on clinical outcomes in patients with mCRPC receiving abiraterone or enzalutamide. Materials and methods: This was a retrospective multicenter study including patients that received abiraterone or enzalutamide for mCRPC. The effect of concurrent statin use on outcomes was evaluated...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29729307/virgin-coconut-oil-vco-by-normalizing-nlrp3-inflammasome-showed-potential-neuroprotective-effects-in-amyloid-%C3%AE-induced-toxicity-and-high-fat-diet-fed-rat
#12
Fatemeh Mirzaei, Mozafar Khazaei, Alireza Komaki, Iraj Amiri, Cyrus Jalili
Both dyslipidemia and Alzheimer disease (AD) are associated with aging. In this study, the effects of virgin coconut oil (VCO) on inflammasome and oxidative stress in Alzheimer's model (receiving Amyloid-β (Aβ)) and high-fat diet (HFD) model were determined. A total of 120 male Wistar rats, were divided into 12 groups (n = 10), including; healthy control, sham surgery, sham surgery receiving normal saline, HFD, HFD + 8% VCO, HFD + 10% VCO, Aβ received rats, Aβ + 8%VCO, Aβ + 10%VCO, HFD + Aβ, HFD + Aβ+8%VCO, and HFD + Aβ + 10%VCO...
May 2, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29728795/-my-heart-die-in-me-idioms-of-distress-and-the-development-of-a-screening-tool-for-mental-suffering-in-southeast-liberia
#13
Katrin Fabian, Josiah Fannoh, George G Washington, Wilfred B Geninyan, Bethuel Nyachienga, Garmai Cyrus, Joyce N Hallowanger, Jason Beste, Deepa Rao, Bradley H Wagenaar
The integration of culturally salient idioms of distress into mental healthcare delivery is essential for effective screening, diagnosis, and treatment. This study systematically explored idioms, explanatory models, and conceptualizations in Maryland County, Liberia to develop a culturally-resonant screening tool for mental distress. We employed a sequential mixed-methods process of: (1) free-lists and semi-structured interviews (n = 20); patient chart reviews (n = 315); (2) pile-sort exercises, (n = 31); and (3) confirmatory focus group discussions (FGDs); (n = 3) from June to December 2017...
May 4, 2018: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/29727228/osteosarcopenia
#14
James Paintin, Cyrus Cooper, Elaine Dennison
Osteosarcopenia is a newly described syndrome that describes the co-existence of osteoporosis and sarcopenia, two chronic musculoskeletal conditions associated with ageing. Osteoporosis, a condition of low bone mass and micro-architectural deterioration of bone, and sarcopenia, the loss of muscle mass, strength and function, often co-exist in a frail subset of the elderly population, leading to significantly worsened outcomes than seen in either condition alone. These include a greater risk of falls, fractures and institutionalization, and significant socioeconomic costs...
May 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29715334/internal-viscosity-dependent-margination-of-red-blood-cells-in-microfluidic-channels
#15
Faisal Ahmed, Marmar Mehrabadi, Zixiang Liu, Gilda A Barabino, Cyrus K Aidun
Cytoplasmic viscosity-dependent margination of red blood cells (RBC) for flow inside microchannels was studied using numerical simulations, and the results were verified with microfluidic experiments. Wide range of suspension volume fractions or hematocrits was considered in this study. Lattice Boltzmann method for fluid-phase coupled with spectrin-link method for RBC membrane deformation was used for accurate analysis of cell margination. RBC margination behavior shows strong dependence on the internal viscosity of the RBCs...
June 1, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29701669/differentiating-medicated-patients-suffering-from-major-depressive-disorder-from-healthy-controls-by-spot-urine-measurement-of-monoamines-and-steroid-hormones
#16
Chandra S Wijaya, Jovia J Z Lee, Syeda F Husain, Cyrus S H Ho, Roger S McIntyre, Wilson W Tam, Roger C M Ho
Introduction : Major Depressive Disorder (MDD) is a common psychiatric disorder. Currently, there is no objective, cost-effective and non-invasive method to measure biological markers related to the pathogenesis of MDD. Previous studies primarily focused on urinary metabolite markers which are not proximal to the pathogenesis of MDD. Herein, we compare urinary monoamines, steroid hormones and the derived ratios amongst MDD when compared to healthy controls. Methods : Morning urine samples of medicated patients suffering from MDD ( n = 47) and healthy controls ( n = 41) were collected...
April 26, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29684104/maternal-vitamin-d-supplementation-during-pregnancy
#17
Elizabeth M Curtis, Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper
Introduction: Maternal vitamin D status in pregnancy has been linked to many health outcomes in mother and offspring. A wealth of observational studies have reported on both obstetric outcomes and complications, including pre-eclampsia, gestational diabetes, mode and timing of delivery. Many foetal and childhood outcomes are also linked to vitamin D status, including measures of foetal size, body composition and skeletal mineralization, in addition to later childhood outcomes, such as asthma...
April 19, 2018: British Medical Bulletin
https://www.readbyqxmd.com/read/29683380/diverse-roles-of-rad18-and-y-family-dna-polymerases-in-tumorigenesis
#18
Yang Yang, Yanzhe Gao, Anastasia Zlatanou, Satoshi Tateishi, Vyacheslav Yurchenko, Igor B Rogozin, Cyrus Vaziri
Mutagenesis is a hallmark and enabling characteristic of cancer cells. The E3 ubiquitin ligase RAD18 and its downstream effectors, the 'Y-family' Trans-Lesion Synthesis (TLS) DNA polymerases, confer DNA damage tolerance at the expense of DNA replication fidelity. Thus, RAD18 and TLS polymerases are attractive candidate mediators of mutagenesis and carcinogenesis. The skin cancer-propensity disorder xeroderma pigmentosum-variant (XPV) is caused by defects in the Y-family DNA polymerase Pol eta (Polη). However it is unknown whether TLS dysfunction contributes more generally to other human cancers...
May 8, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29682376/a-case-of-spontaneously-improving-secondary-hemophagocytic-lymphohistiocytosis-in-an-adult-associated-with-t-cell-histiocyte-rich-large-b-cell-lymphoma
#19
Cyrus Askin, Ashley Burris, Clifton Layman, Brian Haney, Jordan Hall
Secondary hemophagocytic lymphohistiocytosis (HLH) in adults is a rare, often fatal syndrome characterized by widespread immune dysregulation. It is seen as a complication of infections, autoimmune diseases, and malignancies. Among the malignancy-related causes, aggressive T-cell or NK-cell neoplasms are most notable, while B-cell lymphomas are less commonly implicated. We present the case of a 32-year-old male transferred to our facility with concern for HLH. During the first week of his hospitalization, his diagnosis was confirmed and the patient demonstrated spontaneous improvement in his symptoms prompting us to delay therapy while searching for a primary cause...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29681679/anticipating-climatic-variability-the-potential-of-ecological-calendars
#20
Karim-Aly S Kassam, Morgan L Ruelle, Cyrus Samimi, Antonio Trabucco, Jianchu Xu
No abstract text is available yet for this article.
2018: Human Ecology: An Interdisciplinary Journal
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