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https://www.readbyqxmd.com/read/28743612/clinical-outcomes-after-interstitial-brachytherapy-for-early-stage-nasal-squamous-cell-carcinoma
#1
Warren Bacorro, Alexandre Escande, Stéphane Temam, Isabelle Dumas, Emilie Routier, Marie-Catherine Gensse, Pierre Blanchard, François Janot, Christine Mateus, Yungan Tao, Caroline Robert, Eric Deutsch, Christine Haie-Meder, Cyrus Chargari
PURPOSE: Radiotherapy of nasal carcinomas results in cure rates comparable to surgery, with anatomic preservation and good cosmesis. Brachytherapy (BT) overcomes difficulties with dosimetric coverage and affords a localized and highly conformal irradiation. We report our experience of BT for early-stage nasal squamous cell carcinomas (SCCs). METHODS AND MATERIALS: Clinical data, BT parameters, and outcome of consecutive patients treated by interstitial BT in our institute between December 1982 and April 2015 for a localized nasal SCC were examined...
July 22, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28742736/comparative-analysis-of-perioperative-outcomes-using-nationally-derived-hospital-discharge-data-relative-to-a-prospective-multicenter-surgical-database-of-adult-spinal-deformity-surgery
#2
Gregory W Poorman, Peter G Passias, Aaron J Buckland, Cyrus M Jalai, Michael Kelly, Daniel M Sciubba, Brian J Neuman, D Kojo Hamilton, Amit Jain, Bassel Diebo, Virginie Lafage, Shay Bess, Eric O Klineberg
STUDY DESIGN: Retrospective analysis of three prospectively collected databases. OBJECTIVE: To compare perioperative outcomes in Adult Spinal Deformity (ASD) surgeries in a surgeon-run (SR-ASD) and two national databases: the Nationwide Inpatient Sample (NIS) and the National Surgical Quality Improvement Program (NSQIP). SUMMARY OF BACKGROUND DATA: Much has been learned on the treatment of ASD in the last decade with prospective multicenter collaborative research focusing on this specific condition...
August 1, 2017: Spine
https://www.readbyqxmd.com/read/28735127/the-fate-of-adult-spinal-deformity-asd-patients-incurring-rod-fracture-after-thoracolumbar-fusion
#3
D Kojo Hamilton, John A Buza, Peter Passias, Cyrus Jalai, Han Jo Kim, Tamir Ailon, Munish Gupta, Daniel Sciubba, Amit Jain, Christopher P Ames, Vedat Deviren, Alan Daniels, Virginie Lafage, Shay Bess, Eric Klineberg, Christopher I Shaffrey, Justin S Smith, Robert Hart
OBJECTIVE: To report the outcome of adult spinal deformity (ASD) patients with rod fracture following thoracolumbar fusion. METHODS: Retrospective review of prospective, multicenter database. Operative ASD patients ≥18 years old with a rod fracture (RF) after ASD surgery and with a minimum 6-month follow-up after RF were included. Health-related quality of life (HRQoL) scores and radiographic alignment were compared using non-parametric paired and independent testing (p<0...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28734842/hydration-forces-between-aligned-dna-helices-undergoing-b-to-a-conformational-change-in-situ-x-ray-fiber-diffraction-studies-in-a-humidity-and-temperature-controlled-environment
#4
Ryan Case, Hauke Schollmeyer, Phillip Kohl, Eric B Sirota, Roger Pynn, Kai E Ewert, Cyrus R Safinya, Youli Li
Hydration forces between DNA molecules in the A- and B-Form were studied using a newly developed technique enabling simultaneous in situ control of temperature and relative humidity. X-ray diffraction data were collected from oriented calf-thymus DNA fibers in the relative humidity range of 98%-70%, during which DNA undergoes the B- to A-form transition. Coexistence of both forms was observed over a finite humidity range at the transition. The change in DNA separation in response to variation in humidity, i...
July 19, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28727629/an-automated-inpatient-split-dose-bowel-preparation-system-improves-colonoscopy-quality-and-reduces-repeat-procedures
#5
Rena Yadlapati, Elyse R Johnston, Adam B Gluskin, Dyanna L Gregory, Rachel Cyrus, Lindsay Werth, Jody D Ciolino, David P Grande, Rajesh N Keswani
BACKGROUND/GOALS: Inpatient colonoscopy preparations are often inadequate, compromising patient safety and procedure quality, while resulting in greater hospital costs. The aims of this study were to: (1) design and implement an electronic inpatient split-dose bowel preparation order set; (2) assess the intervention's impact upon preparation adequacy, repeated colonoscopies, hospital days, and costs. STUDY: We conducted a single center prospective pragmatic quasiexperimental study of hospitalized adults undergoing colonoscopy...
July 19, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28726718/inhibitory-effects-of-trapping-agents-of-sulfur-drug-reactive-intermediates-against-major-human-cytochrome-p450-isoforms
#6
Jasleen K Sodhi, Erlie Marie Delarosa, Jason S Halladay, James P Driscoll, Teresa Mulder, Patrick M Dansette, S Cyrus Khojasteh
In some cases, the formation of reactive species from the metabolism of xenobiotics has been linked to toxicity and therefore it is imperative to detect potential bioactivation for candidate drugs during drug discovery. Reactive species can covalently bind to trapping agents in in vitro incubations of compound with human liver microsomes (HLM) fortified with β-nicotinamide adenine dinucleotide phosphate (NADPH), resulting in a stable conjugate of trapping agent and reactive species, thereby facilitating analytical detection and providing evidence of short-lived reactive metabolites...
July 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28724471/what-influences-diet-quality-in-older-people-a-qualitative-study-among-community-dwelling-older-adults-from-the-hertfordshire-cohort-study-uk
#7
Ilse Bloom, Wendy Lawrence, Mary Barker, Janis Baird, Elaine Dennison, Avan Aihie Sayer, Cyrus Cooper, Sian Robinson
OBJECTIVE: To explore influences on diet in a group of community-dwelling older adults in the UK. DESIGN: Data were collected through focus group discussions with older people; discussions were audio-recorded, transcribed verbatim and transcripts analysed thematically. SETTING: Hertfordshire, UK. SUBJECTS: Participants were sampled purposively from the Hertfordshire Cohort Study, focusing on those whose diets had been assessed at two time points: 1998-2001 and 2011...
July 20, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28715713/metastasis-systems-biology-how-are-macro-environmental-signals-transmitted-into-microenvironmental-cues-for-disseminated-tumor-cells
#8
REVIEW
Candice Alexandra Grzelak, Cyrus Michael Ghajar
Disseminated breast tumor cells reside on or near stable microvascular endothelium. Currently, the cues that disrupt DTC dormancy and facilitate outgrowth are largely unknown. This article explores the hypothesis that specific patient lifestyle exposures (e.g., alcohol abuse) may disrupt the microenvironments that maintain disseminated tumor cell (DTC) dormancy in a tissue-specific fashion. We suggest that such exposures are 'transmitted' to the dormant niche in the form of injury. Thus, we discuss the relationship between wound healing and metastasis using liver as an example to illustrate how injury steers the phenotype of liver endothelium and perivascular hepatic stellate cells to a potentially pro-metastatic one...
July 14, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28714823/seeing-the-big-picture-sustaining-success-in-liaison-services
#9
Roy E Brown, John Cyrus, Irene Lubker, Karen Gau, Jennifer Opoku, Barbara Wright, Emily J Hurst
While the liaison program at the Tompkins-McCaw Library for the Health Sciences has existed for more than 15 years, it has yet to be fully evaluated. This article seeks to evaluate the scope and impact of the program at a broad level using quantitative and qualitative data. Descriptive statistics to summarize liaison activity were collected for the fiscal years 2012-2016. In addition, liaisons and users were surveyed to gain insight into the effectiveness and the perception of the program. Program statistics show that users' engagement with liaisons is high and growing...
July 2017: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/28714229/implementing-a-protocol-to-optimize-blood-use-in-a-cardiac-surgery-service-results-of-a-pre-post-analysis-and-the-impact-of-high-volume-blood-users
#10
Juan B Grau, Jacqueline H Fortier, Cyrus Kuschner, Giovanni Ferrari, Mariano E Brizzio, Alex Zapolanski, Richard E Shaw
BACKGROUND: Blood transfusions are a common and costly intervention for cardiac surgery patients. Evidence suggests that a more restrictive transfusion strategy may reduce costs and transfusion-related complications without increasing perioperative morbidity and mortality. STUDY DESIGN AND METHODS: A transfusion-limiting protocol was developed and implemented in a cardiovascular surgery unit. Over a 5-year period, data were collected on patient characteristics, procedures, utilization of blood products, morbidity, and mortality, and these were compared before and after the protocol was implemented...
July 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28699487/mixed-matrix-method-provides-a-reliable-metabolite-exposure-comparison-for-assessment-of-metabolite-in-safety-testing-mist
#11
Ryan Takahashi, Cyrus Khojasteh, Matthew Wright, Cornelis Hop, Shuguang Ma
The regulatory guidances on metabolites in safety testing (MIST) by US Food and Drug Administration (FDA) and International Conference on Harmonisation (ICH) describe the necessity to assess exposures of circulating metabolites in humans at steady state relative to exposures achieved in nonclinical safety studies prior to the initiation of large scale clinical trials. This comparison can be accomplished by measuring metabolite concentrations in animals and humans with validated bioanalytical methods. However, bioanalysis of metabolites in multiple species and multiple studies is resource intensive and may impact the timelines of clinical studies...
July 10, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/28693798/brain-metastases-from-non-small-cell-lung-carcinoma-changing-concepts-for-improving-patients-outcome
#12
REVIEW
Chloé Rancoule, Alexis Vallard, Jean-Baptiste Guy, Sophie Espenel, Peng Diao, Cyrus Chargari, Nicolas Magné
The management of Non Small Cell Lung Cancer (NSCLC) brain metastases is challenging, as this frequent complication negatively impacts patients' quality of life, and can be a life-threatening event. Through a review of the literature, we discuss the main therapeutic options and the recent developments that improved (and complicated) the management of NSCLC brain metastases patients. Most current validated approaches are local with exclusive or combined surgery, whole brain radiotherapy (WBRT) and stereotactic radiotherapy (SRT)...
August 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28688984/patient-profiling-can-identify-adult-spinal-deformity-asd-patients-at-risk-for-conversion-from-nonoperative-to-surgical-treatment-initial-steps-to-reduce-ineffective-asd-management
#13
Peter G Passias, Cyrus M Jalai, Breton G Line, Gregory W Poorman, Justin K Scheer, Justin S Smith, Christopher I Shaffrey, Douglas C Burton, Kai-Ming G Fu, Eric O Klineberg, Robert A Hart, Frank Schwab, Virginie Lafage, Shay Bess
BACKGROUND CONTEXT: Non-operative management is a common initial treatment for adult spinal deformity (ASD) patients despite reported superiority of surgery with regard to outcomes. Ineffective medical care is a large source of resource drain on the health system. Characterization of ASD patients likely to elect for operative treatment from nonoperative management may allow for more efficient patient counseling and cost savings. PURPOSE: To identify deformity and disability characteristics of ASD patients that ultimately convert to operative treatment compared to those that remain non-operative and those that initially choose surgery...
July 5, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28680770/reducing-over-utilization-of-cardiac-telemetry-with-pop-ups-in-an-electronic-medical-record-system
#14
Wajeeha Rizvi, Cyrus M Munguti, Jeet Mehta, K James Kallail, Darrell Youngman, Samer Antonios
Non-invasive cardiac monitoring has well-established indications and protocols. Telemetry is often overused leading to a shortage of tele-beds and an increment of hospital expenses. In some cases, patients are kept on telemetry longer than the indicated length because providers are unaware of its ongoing use. We investigated the effect of reminder pop-ups, incorporated into an electronic medical record (EMR), on minimizing the use of telemetry. Three regional hospitals implemented an electronic pop-up reminder for discontinuing the use of telemetry when no longer indicated...
May 29, 2017: Curēus
https://www.readbyqxmd.com/read/28673888/two-year-results-of-the-prospective-spine-treatment-outcomes-study-an-analysis-of-complication-rates-predictors-of-their-development-and-effect-on-patient-derived-outcomes-at-2-years-for-surgical-management-of-cervical-spondylotic-myelopathy
#15
Michael C Gerling, Peter Passias, Kris Radcliff, Robert Isaacs, Kristina Bianco, Cyrus M Jalai, Nancy J Worley, Jaspreet Parmar, Gregory W Poorman, Samantha R Horn, John Y Moon, Paul M Arnold, Alexander R Vaccaro
No abstract text is available yet for this article.
June 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28673821/the-effects-of-chemical-fixation-on-the-cellular-nanostructure
#16
Yue Li, Luay M Almassalha, John E Chandler, Xiang Zhou, Yolanda E Stypula-Cyrus, Karl A Hujsak, Eric W Roth, Reiner Bleher, Hariharan Subramanian, Igal Szleifer, Vinayak P Dravid, Vadim Backman
Chemical fixation is nearly indispensable in the biological sciences, especially in circumstances where cryo-fixation is not applicable. While universally employed for the preservation of cell organization, chemical fixatives often introduce artifacts that can confound identification of true structures. Since biological research is increasingly probing ever-finer details of the cellular architecture, it is critical to understand the nanoscale transformation of the cellular organization due to fixation both systematically and quantitatively...
June 30, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28673762/diffusion-weighted-mri-in-image-guided-adaptive-brachytherapy-tumor-delineation-feasibility-study-and-comparison-with-gec-estro-guidelines
#17
Antoine Schernberg, Corinne Balleyguier, Isabelle Dumas, Sébastien Gouy, Alexandre Escande, Enrica Bentivegna, Philippe Morice, Eric Deutsch, Christine Haie-Meder, Cyrus Chargari
PURPOSE: To examine the feasibility of using diffusion-weighted images (DWIs) coregistered with T2-weighted (T2w) sequence in treatment planning system to improve target delineation for image-guided adaptive brachytherapy (IGABT) in locally advanced cervical cancer patients. METHODS AND MATERIALS: We retrospectively examined the records of consecutive patients who were referred to our institution for pulse-dose-rate IGABT between May and December 2015 after concurrent chemoradiation...
June 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28665882/continuous-quality-improvement-intervention-for-adolescent-and-young-adult-hiv-testing-services-in-kenya-improves-hiv-knowledge
#18
Anjuli D Wagner, Cyrus Mugo, Shay Bluemer-Miroite, Peter M Mutiti, Dalton C Wamalwa, David Bukusi, Jillian Neary, Irene N Njuguna, Gabrielle O'Malley, Grace C John-Stewart, Jennifer A Slyker, Pamela K Kohler
OBJECTIVES: To determine whether continuous quality improvement (CQI) improves quality of HIV testing services for adolescents and young adults (AYA). DESIGN: CQI was introduced at two HIV testing settings: Youth Centre and Voluntary Counseling and Testing (VCT) Center, at a national referral hospital in Nairobi, Kenya. METHODS: Primary outcomes were AYA satisfaction with HIV testing services, intent to return, and accurate HIV prevention and transmission knowledge...
July 1, 2017: AIDS
https://www.readbyqxmd.com/read/28665879/-at-our-age-we-would-like-to-do-things-the-way-we-want-a-qualitative-study-of-adolescent-hiv-testing-services-in-kenya
#19
Kate S Wilson, Kristin M Beima-Sofie, Helen Moraa, Anjuli D Wagner, Cyrus Mugo, Peter M Mutiti, Dalton Wamalwa, David Bukusi, Grace C John-Stewart, Jennifer A Slyker, Pamela K Kohler, Gabrielle O'Malley
OBJECTIVES: Adolescents in Africa have low HIV testing rates. Better understanding of adolescent, provider, and caregiver experiences in high-burden countries such as Kenya could improve adolescent HIV testing programs. DESIGN: We conducted 16 qualitative interviews with HIV-positive and HIV-negative adolescents (13-18 years) and six focus group discussions with Healthcare workers (HCWs) and caregivers of adolescents in Nairobi, Kenya. METHODS: Semi-structured interviews and focus groups were recorded and transcribed...
July 1, 2017: AIDS
https://www.readbyqxmd.com/read/28664458/quality-of-life-assessment-in-musculo-skeletal-health
#20
REVIEW
Charlotte Beaudart, Emmanuel Biver, Olivier Bruyère, Cyrus Cooper, Nasser Al-Daghri, Jean-Yves Reginster, René Rizzoli
Musculoskeletal disorders affect morbidity, quality of life and mortality, and represent an increasing economic and societal burden in the context of population aging and increased life expectancy. Improvement of quality of life should be one of the priorities of any interventions to prevent and treat musculoskeletal disorders in the ageing population. Two main approaches, namely generic and disease-specific instruments, can be applied to measure health-related quality of life. Among the generic tools available in scientific literature, the short form 36 questionnaire (SF-36) and the Euroqol five item questionnaire (EQ-5D) are two of the most popular questionnaires used to quantify the health related quality of life in people with musculoskeletal disorders...
June 29, 2017: Aging Clinical and Experimental Research
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