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https://www.readbyqxmd.com/read/29350505/bridging-the-digital-divide-mobile-access-to-personal-health-records-among-patients-with-diabetes
#1
Ilana Graetz, Jie Huang, Richard J Brand, John Hsu, Cyrus K Yamin, Mary E Reed
OBJECTIVES: Some patients lack regular computer access and experience a digital divide that causes them to miss internet-based health innovations. The diffusion of smartphones has increased internet access across the socioeconomic spectrum, and increasing the channels through which patients can access their personal health records (PHRs) could help bridge the divide in PHR use. We examined PHR use through a computer-based Web browser or mobile device. STUDY DESIGN: Cross-sectional historical cohort analysis...
January 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29349935/pitfalls-in-the-measurement-of-muscle-mass-a-need-for-a-reference-standard
#2
Fanny Buckinx, Francesco Landi, Matteo Cesari, Roger A Fielding, Marjolein Visser, Klaus Engelke, Stefania Maggi, Elaine Dennison, Nasser M Al-Daghri, Sophie Allepaerts, Jurgen Bauer, Ivan Bautmans, Maria Luisa Brandi, Olivier Bruyère, Tommy Cederholm, Francesca Cerreta, Antonio Cherubini, Cyrus Cooper, Alphonso Cruz-Jentoft, Eugene McCloskey, Bess Dawson-Hughes, Jean-Marc Kaufman, Andrea Laslop, Jean Petermans, Jean-Yves Reginster, René Rizzoli, Sian Robinson, Yves Rolland, Ricardo Rueda, Bruno Vellas, John A Kanis
BACKGROUND: All proposed definitions of sarcopenia include the measurement of muscle mass, but the techniques and threshold values used vary. Indeed, the literature does not establish consensus on the best technique for measuring lean body mass. Thus, the objective measurement of sarcopenia is hampered by limitations intrinsic to assessment tools. The aim of this study was to review the methods to assess muscle mass and to reach consensus on the development of a reference standard. METHODS: Literature reviews were performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis working group on frailty and sarcopenia...
January 19, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29348271/intratumoral-payload-concentration-correlates-with-the-activity-of-antibody-drug-conjugates
#3
Donglu Zhang, Shang-Fan Yu, S Cyrus Khojasteh, Yong Ma, Thomas H Pillow, Jack D Sadowsky, Dian Su, Katherine R Kozak, Keyang Xu, Andrew G Polson, Peter Dragovich, Cornelis Eca Hop
Antibody-drug conjugates (ADCs) have become important scaffolds for targeted cancer therapies. However, ADC exposure - response correlation is not well characterized. We demonstrated that intratumor payload exposures correlated well with the corresponding efficacies of several disulfide-linked ADCs bearing an DNA alkylating agent, pyrrolo[2,1-c][1,4]benzodiazepine-dimer (PBD), in HER2-expressing xenograft models. The correlation suggests that a threshold concentration of intratumor payload is required to support sustained efficacy and an ADC can deliver an excessive level of payload to tumors that does not enhance efficacy ('Plateau' effect)...
January 18, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29347073/orientational-dynamics-of-a-triaxial-ellipsoid-in-simple-shear-flow-influence-of-inertia
#4
Tomas Rosén, Yusuke Kotsubo, Cyrus K Aidun, Minh Do-Quang, Fredrik Lundell
The motion of a single ellipsoidal particle in simple shear flow can provide valuable insights toward understanding suspension flows with nonspherical particles. Previously, extensive studies have been performed on the ellipsoidal particle with rotational symmetry, a so-called spheroid. The nearly prolate ellipsoid (one major and two minor axes of almost equal size) is known to perform quasiperiodic or even chaotic orbits in the absence of inertia. With small particle inertia, the particle is also known to drift toward this irregular motion...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29326122/growth-factor-independence-1b-a-key-player-in-the-genesis-and-maintenance-of-acute-myeloid-leukaemia-and-myelodysplastic-syndrome
#5
Aniththa Thivakaran, Lacramiora Botezatu, Judith M Hönes, Judith Schütte, Lothar Vassen, Yahya S Al-Matary, Pradeep Patnana, Amos Zeller, Michael Heuser, Felicitas Thol, Razif Gabdoulline, Nadine Olberding, Daria Frank, Marina Suslo, Renata Köster, Klaus Lennartz, Andre Görgens, Bernd Giebel, Bertram Opalka, Ulrich Dührsen, Cyrus Khandanpour
Differentiation of haematopoietic stem cells is regulated by a concert of different transcription factors. Disturbed transcription factors function can be the basis of (pre)malignancies such as myelodysplastic syndrome or acute myeloid leukaemia. Growth factor independence 1b is a repressing transcription factor regulating quiescence of hematopoietic stem cellss and differentiation of erythrocytes and platelets. Here, we show that low expression of Growth factor independence 1b in blast cells is associated with an inferior prognosis of myelodysplastic syndrome and acute myeloid leukaemia patients...
January 11, 2018: Haematologica
https://www.readbyqxmd.com/read/29325690/dose-volume-effects-in-pathologic-lymph-nodes-in-locally-advanced-cervical-cancer
#6
Warren Bacorro, Isabelle Dumas, Alexandre Escande, Sebastien Gouy, Enrica Bentivegna, Philippe Morice, Christine Haie-Meder, Cyrus Chargari
OBJECTIVE: In cervical cancer patients, dose-volume relationships have been demonstrated for tumor and organs-at-risk, but not for pathologic nodes. The nodal control probability (NCP) according to dose/volume parameters was investigated. MATERIAL AND METHODS: Patients with node-positive cervical cancer treated curatively with external beam radiotherapy (EBRT) and image-guided brachytherapy (IGABT) were identified. Nodal doses during EBRT, IGABT and boost were converted to 2-Gy equivalent (α/β = 10 Gy) and summed...
January 8, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29324531/response-to-a-letter-to-the-editor
#7
Shaleen Vira, Qasim Husain, Cyrus Jalai, Justin Paul, Gregory W Poorman, Caroline Poorman, Richard S Yoon, Christopher Looze, Baron Lonner, Peter G Passias
No abstract text is available yet for this article.
January 10, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29314248/calcium-and-vitamin-d-supplementation-are-not-associated-with-risk-of-incident-ischaemic-cardiac-events-or-death-findings-from-the-uk-biobank-cohort
#8
Nicholas C Harvey, Stefania D'Angelo, Julien Paccou, Elizabeth M Curtis, Mark Edwards, Zahra Raisi-Estabragh, Karen Walker-Bone, Steffen E Petersen, Cyrus Cooper
We investigated associations between calcium/vitamin D supplementation and incident cardiovascular events/deaths in a UK population-based cohort. UK Biobank is a large prospective cohort comprising 502,637 men and women aged 40-69 years at recruitment. Supplementation with calcium/vitamin D was self-reported, and information on incident hospital admission (ICD-10) for ischaemic heart disease (IHD), myocardial infarction (MI) any cardiovascular event, and subsequent death, was obtained from linkage to national registers...
January 4, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29310651/stabilization-of-rdt-target-antigens-present-in-dried-plasmodium-falciparum-infected-samples-for-validating-malaria-rapid-diagnostic-tests-at-the-point-of-care
#9
Collins Morang'a, Cyrus Ayieko, George Awinda, Rachel Achilla, Caroline Moseti, Bernhards Ogutu, John Waitumbi, Elizabeth Wanja
BACKGROUND: Malaria rapid diagnostic tests (RDTs) are a great achievement in implementation of parasite based diagnosis as recommended by World Health Organization. A major drawback of RDTs is lack of positive controls to validate different batches/lots at the point of care. Dried Plasmodium falciparum-infected samples with the RDT target antigens have been suggested as possible positive control but their utility in resource limited settings is hampered by rapid loss of activity over time...
January 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29309502/social-isolation-and-loneliness-as-risk-factors-for-the-progression-of-frailty-the-english-longitudinal-study-of-ageing
#10
Catharine R Gale, Leo Westbury, Cyrus Cooper
Background: loneliness and social isolation have been associated with mortality and with functional decline in older people. We investigated whether loneliness or social isolation are associated with progression of frailty. Methods: participants were 2,817 people aged ≥60 from the English Longitudinal Study of Ageing. Loneliness was assessed at Wave 2 using the Revised UCLA scale (short version). A social isolation score at Wave 2 was derived from data on living alone, frequency of contact with friends, family and children, and participation in social organisations...
December 22, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29307201/risk-factors-biomarker-and-imaging-techniques-used-for-pancreatic-cancer-screening
#11
Cyrus Thomas
Pancreatic cancer (PC) is one of the most lethal epithelial malignancies. There have been many attempts aimed at improving survival rates; however, the fatality of PC has been attributed to its few, nonspecific and diverse symptoms that delay diagnosis, rapid metastatic progression and overall treatment resistance. The aggressive nature of PC has stimulated interest in detecting smaller asymptomatic cancers or precursor lesions that are more likely to be curable. This review discusses potential risk factors including lifestyle and genetic variables that are believed to be the most important in contributing to the development of PC...
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29287769/guidelines-for-the-conduct-of-pharmacological-clinical-trials-in-hand-osteoarthritis-consensus-of-a-working-group-of-the-european-society-on-clinical-and-economic-aspects-of-osteoporosis-osteoarthritis-and-musculoskeletal-diseases-esceo
#12
REVIEW
Jean-Yves L Reginster, Nigel K Arden, Ida K Haugen, Francois Rannou, Etienne Cavalier, Olivier Bruyère, Jaime Branco, Roland Chapurlat, Sabine Collaud Basset, Nasser M Al-Daghri, Elaine M Dennison, Gabriel Herrero-Beaumont, Andrea Laslop, Burkhard F Leeb, Stefania Maggi, Ouafa Mkinsi, Anton S Povzun, Daniel Prieto-Alhambra, Thierry Thomas, Daniel Uebelhart, Nicola Veronese, Cyrus Cooper
OBJECTIVES: To gather expert opinion on the conduct of clinical trials that will facilitate regulatory review and approval of appropriate efficacious pharmacological treatments for hand osteoarthritis (OA), an area of high unmet clinical need. METHODS: The European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal diseases (ESCEO) organized a working group under the auspices of the International Osteoporosis Foundation (IOF) and the World Health Organization (WHO)...
December 7, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29282109/simulated-patient-encounters-to-improve-adolescent-retention-in-hiv-care-in-kenya-study-protocol-of-a-stepped-wedge-randomized-controlled-trial
#13
Kate S Wilson, Cyrus Mugo, David Bukusi, Irene Inwani, Anjuli D Wagner, Helen Moraa, Tamara Owens, Joseph B Babigumira, Barbra A Richardson, Grace C John-Stewart, Jennifer A Slyker, Dalton C Wamalwa, Pamela K Kohler
BACKGROUND: Adolescent-friendly policies aim to tailor HIV services for adolescents and young adults aged 10-24 years (AYA) to promote health outcomes and improve retention in HIV care and treatment. However, few interventions focus on improving healthcare worker (HCW) competencies and skills for provision of high-quality adolescent care. Standardized patients (SPs) are trained actors who work with HCWs in mock clinical encounters to improve clinical assessment, communication, and empathy skills...
December 28, 2017: Trials
https://www.readbyqxmd.com/read/29280769/disclosure-consent-opportunity-costs-and-inaccurate-risk-assessment-deter-pediatric-hiv-testing-a-mixed-methods-study
#14
Anjuli D Wagner, Gabrielle O'malley, Olivia Firdawsi, Cyrus Mugo, Irene N Njuguna, Elizabeth Maleche-Obimbo, Irene W Inwani, Dalton C Wamalwa, Grace C John-Stewart, Jennifer A Slyker
(250/250 words) BACKGROUND:: Prompt child HIV testing and treatment is critical; however, children are often not diagnosed until symptomatic. Understanding factors that influence pediatric HIV testing can inform strategies to increase testing. METHODS: A mixed-methods study was conducted at a tertiary hospital in Nairobi, Kenya. Three focus group discussions with health care workers (HCW) and 18 in-depth interviews with HIV-infected adults with children of unknown status were analyzed using thematic analysis...
December 22, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29277321/network-meta-analysis-of-cardiovascular-outcomes-in-randomized-controlled-trials-of-new-antidiabetic-drugs
#15
Yue Fei, Man-Fung Tsoi, Cyrus Rustam Kumana, Tommy Tsang Cheung, Bernard Man Yung Cheung
BACKGROUND: Randomized controlled trials (RCTs) directly comparing cardiovascular outcomes of new antidiabetic drugs are lacking. We used network meta-analysis to compare new antidiabetic drug classes with respect to major adverse cardiovascular events (MACE) and mortality. METHODS: We searched MEDLINE, EMBASE, the Cochrane database, and ClinicalTrials.gov up to 30 December 2016 for RCTs involving SGLT-2 inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors in diabetic patients that reported MACE and deaths...
December 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29276552/characteristics-of-school-districts-that-participate-in-rigorous-national-educational-evaluations
#16
Elizabeth A Stuart, Stephen H Bell, Cyrus Ebnesajjad, Robert B Olsen, Larry L Orr
Given increasing interest in evidence-based policy, there is growing attention to how well the results from rigorous program evaluations may inform policy decisions. However, little attention has been paid to documenting the characteristics of schools or districts that participate in rigorous educational evaluations, and how they compare to potential target populations for the interventions that were evaluated. Utilizing a list of the actual districts that participated in 11 large-scale rigorous educational evaluations, we compare those districts to several different target populations of districts that could potentially be affected by policy decisions regarding the interventions under study...
2017: Journal of Research on Educational Effectiveness
https://www.readbyqxmd.com/read/29260059/hypertensive-crisis-with-massive-retinal-and-choroidal-infarction
#17
Cyrus Golshani, Ronni M Lieberman, Robert M Fischer, Scott E Brodie
No abstract text is available yet for this article.
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29259824/health-system-effects-of-implementing-integrated-community-case-management-iccm-intervention-in-private-retail-drug-shops-in-south-western-uganda-a-qualitative-study
#18
Freddy Eric Kitutu, Chrispus Mayora, Emily White Johansson, Stefan Peterson, Henry Wamani, Maryam Bigdeli, Zubin Cyrus Shroff
Background: Intervening in private drug shops to improve quality of care and enhance regulatory oversight may have health system effects that need to be understood before scaling up any such interventions. We examine the processes through which a drug shop intervention culminated in positive unintended effects and other dynamic interactions within the underlying health system. Methods: A multifaceted intervention consisting of drug seller training, supply of diagnostics and subsidised medicines, use of treatment algorithms, monthly supervision and community sensitisation was implemented in drug shops in South Western Uganda, to improve paediatric fever management...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29251595/natural-variation-in-stochastic-photoreceptor-specification-and-color-preference-in-drosophila
#19
Caitlin Anderson, India Reiss, Cyrus Zhou, Annie Cho, Haziq Siddiqi, Benjamin Mormann, Cameron M Avelis, Peter Deford, Alan Bergland, Elijah Roberts, James Taylor, Daniel Vasiliauskas, Robert J Johnston
Each individual perceives the world in a unique way, but little is known about the genetic basis of variation in sensory perception. In the fly eye, the random mosaic of color-detecting R7 photoreceptor subtypes is determined by stochastic on/off expression of the transcription factor Spineless (Ss). In a genome-wide association study, we identified a naturally occurring insertion in a regulatory DNA element in ss that lowers the ratio of SsON to SsOFF cells. This change in photoreceptor fates shifts the innate color preference of flies from green to blue...
December 18, 2017: ELife
https://www.readbyqxmd.com/read/29248781/drivers-of-cervical-deformity-have-a-strong-influence-on-achieving-optimal-radiographic-and-clinical-outcomes-at-1-year-following-cervical-deformity-surgery
#20
Peter G Passias, Cole Bortz, Samantha Horn, Frank Segreto, Gregory Poorman, Cyrus Jalai, Alan Daniels, D Kojo Hamilton, Han Jo Kim, Daniel Sciubba, Justin S Smith, Brian Neuman, Christopher Shaffrey, Virginie Lafage, Themistocles Protopsaltis, Christopher Ames, Robert Hart, Gregory Mundis, Robert Eastlack
OBJECTIVE: The primary driver (PD) of cervical malalignment is important in characterizing cervical deformity(CD) and should be included in fusion to achieve alignment and quality-of-life goals. This study aims to define how PDs improve understanding of the mechanisms of cervical deformity, and assesses the impact of driver region on re-alignment/outcomes. METHODS: Inclusion: radiographic cervical deformity, >18 years, 1-year follow-up. PD apex was classified by spinal region: cervical, cervicothoracic junction(CTJ), thoracic, or spino-pelvic by panel of spine deformity surgeons...
December 14, 2017: World Neurosurgery
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