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https://www.readbyqxmd.com/read/28339495/microrna-expression-profiles-identify-disease-specific-alterations-in-systemic-lupus-erythematosus-and-primary-sj%C3%A3-gren-s-syndrome
#1
Ji-Qing Chen, Gábor Papp, Szilárd Póliska, Krisztina Szabó, Tünde Tarr, Bálint László Bálint, Péter Szodoray, Margit Zeher
The discovery of microRNAs (miRNAs) and their critical role in genetic control opened new avenues in understanding of various biological processes including immune cell lineage commitment, differentiation, proliferation and apoptosis. However, a given miRNA may have hundreds of different mRNA targets and a target might be regulated by multiple miRNAs, thus the characterisation of dysregulated miRNA expression profiles could give a better insight into the development of immunological disturbances in autoimmune diseases...
2017: PloS One
https://www.readbyqxmd.com/read/28333597/when-is-parenteral-nutrition-appropriate
#2
Patricia Worthington, Jane Balint, Matthew Bechtold, Angela Bingham, Lingtak-Neander Chan, Sharon Durfee, Andrea K Jevenn, Ainsley Malone, Maria Mascarenhas, Daniel T Robinson, Beverly Holcombe
Parenteral nutrition (PN) represents one of the most notable achievements of modern medicine, serving as a therapeutic modality for all age groups across the healthcare continuum. PN offers a life-sustaining option when intestinal failure prevents adequate oral or enteral nutrition. However, providing nutrients by vein is an expensive form of nutrition support, and serious adverse events can occur. In an effort to provide clinical guidance regarding PN therapy, the Board of Directors of the American Society for Parenteral and Enteral Nutrition (ASPEN) convened a task force to develop consensus recommendations regarding appropriate PN use...
March 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28317462/witnesses-in-the-consultation-room-experiences-of-peer-group-supervision
#3
Helena Galina Nielsen, Annette Sofie Davidsen
BACKGROUND: In Denmark group supervision for general practitioners is an established part of continuing professional development. Several different approaches are used, including Balint Groups and Bendix Groups. The aim of this paper is to describe the benefits and challenges of a peer group supervision model with the role of supervisor taken by group members in turn. The setting was a group of general practitioners using a patient-centred consultation model and video-recordings of consultations...
March 19, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28236526/-atypical-atypical-parkinsonism-critical-appraisal-of-a-cohort
#4
Stephanie T Hirschbichler, Roberto Erro, Christos Ganos, Maria Stamelou, Amit Batla, Bettina Balint, Kailash P Bhatia
BACKGROUND: Atypical parkinsonian conditions such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal syndrome (CBS) and Dementia with Lewy bodies (DLB) comprise 10-15% of parkinsonian syndromes. Misdiagnosis with Parkinson disease (PD) and within the entities is common, given the absence of reliable biomarkers. However a correct diagnosis is not only important in clinical practice, but also crucial for any trial attempting to identify biomarkers or new treatments...
December 14, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28188510/medication-use-and-risk-of-falls-among-nursing-home-residents-a-retrospective-cohort-study
#5
Andrea Bor, Mária Matuz, Márta Csatordai, Gábor Szalai, András Bálint, Ria Benkő, Gyöngyvér Soós, Péter Doró
Background Geriatric falls are leading causes of hospital trauma admissions and injury-related deaths. Medication use is a crucial element among extrinsic risk factors for falls. To reduce fall risk and the prevalence of adverse drug reactions, potentially inappropriate medication (PIM) lists are widely used. Objective Our aim was to investigate the possible predictors of geriatric falls annualized over a 5-year-long period, as well as to evaluate the medication use of nursing home residents. Setting Nursing home residents were recruited from the same institution between 2010 and 2015 in Szeged, Hungary...
February 10, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28116931/-at-what-age-can-children-perform-effective-cardiopulmonary-resuscitation-effectiveness-of-cardiopulmonary-resuscitation-skills-among-primary-school-children
#6
Bálint Bánfai, Attila Pandur, Emese Pék, Henrietta Csonka, József Betlehem
INTRODUCTION: In cardiac arrest life can be saved by bystanders. AIM: Our aim was to determine at what age can schoolchildren perform correct cardiopulmonary resuscitation. METHOD: 164 schoolchildren (age 7-14) were involved in the study. A basic life support training consisted of 45 minutes education in small groups (8-10 children). They were tested during a 2-minute-long continuous cardiopulmonary resuscitation scenario using the "AMBU CPR Software"...
January 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28076371/meta-analysis-of-the-long-term-success-rate-of-different-interventions-in-benign-biliary-strictures
#7
Orsolya Huszár, Bálint Kokas, Péter Mátrai, Péter Hegyi, Erika Pétervári, Áron Vincze, Gabriella Pár, Patrícia Sarlós, Judit Bajor, József Czimmer, Dóra Mosztbacher, Katalin Márta, Csaba Zsiborás, Péter Varjú, Ákos Szücs
BACKGROUND: Benign biliary stricture is a rare condition and the majority of the cases are caused by operative trauma or chronic inflammation based on various etiology. Although the initial results of endoscopic, percutaneous and surgical treatment are impressive, no comparison about long term stricture resolution is available. AIMS: The goal of this study was to compare the long term disease free survival in benign biliary strictures with various etiology after surgery, percutaneous transhepatic-and endoscopic treatment...
2017: PloS One
https://www.readbyqxmd.com/read/27984762/hcv-prevalence-and-risk-behaviours-among-injectors-of-new-psychoactive-substances-in-a-risk-environment-in-hungary-an-expanding-public-health-burden
#8
Anna Tarján, Mária Dudás, Lucas Wiessing, Gergely Horváth, Erzsébet Rusvai, Bálint Tresó, Ágnes Csohán
BACKGROUND: In Hungary a large increase in injecting new psychoactive substances (NPS) coincided with decreasing harm reduction efforts and rising HCV infection. We describe these, and assess changes in HCV prevalence and risk behaviours, 2011-2014, among NPS injectors, using 2011-2015 syringe exchange programme (SEP) data as a key contextual ('risk environment') variable. METHODS: We conducted repeated national sero-behavioural surveys in people who inject drugs (PWID) injecting in the last month and attending SEPs or drug treatment centres (n=399, 2011; 384, 2014), using face-to-face interviews and dried blood-spot samples...
December 13, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27936879/-cryosclerosis-the-forgotten-endovenous-cryoablation-of-the-great-saphenous-vein-mid-term-results-of-a-prospective-comparative-trial
#9
István Bence Bálint, Ákos Farics, László Vizsy, Eszter Vargovics, Renáta Bálint, József Bátorfi, Gábor Menyhei
INTRODUCTION: Cryosclerosis was introduced by Milleret and Le Pivert in the 1980s. METHOD: A prospective non-randomized comparative study has been performed on initial 96 patients. 48 patients were treated by cryosclerosis and the others received conventional stripping. 52 cases were analyzed for 2-years. The primary end-point of the study was to determine the occlusion rate of cryosclerosis. The clinical failure, the improvement in the Clinical Etiologic Anatomic Pathophysiologic classification and Venous Clinical Severity Scores were analyzed as secondary outcome...
December 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27889978/-analysis-of-plantar-pressure-patterns-among-obese-population
#10
Eleonóra Leidecker, Péter Kellermann, Mónika Galambosné Tiszberger, Bálint Molics, Aliz Bohner-Beke, József Nyárády, János Kránicz
INTRODUCTION: Although the role of body weight on foot health and load has been widely documented in research, the effect of the extra load due to body weight on plantar pressure characteristics is not well known. AIM: The aim of this study was to evaluate the impact of obesity on plantar pressure patterns among the working-age population. METHOD: 180 participants were involved. Two groups were evaluated according to body mass index categories regarding eight regions of the plantar area, focusing on the following parameters: contact area, maximum pressure and peak pressure...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27875525/precision-medicine-in-cancer-challenges-and-recommendations-from-an-eu-funded-cervical-cancer-biobanking-study
#11
Sanne Samuels, Balazs Balint, Heiko von der Leyen, Philippe Hupé, Leanne de Koning, Choumouss Kamoun, Windy Luscap-Rondof, Ulrike Wittkop, Ksenia Bagrintseva, Marina Popovic, Atttila Kereszt, Els Berns, Gemma G Kenter, Ekaterina S Jordanova, Maud Kamal, Susy Scholl
BACKGROUND: Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality worldwide. CC pathogenesis is triggered when human papillomavirus (HPV) inserts into the genome, resulting in tumour suppressor gene inactivation and oncogene activation. Collecting tumour and blood samples is critical for identifying these genetic alterations. METHODS: BIO-RAIDs is the first prospective molecular profiling clinical study to include a substantial biobanking effort that used uniform high-quality standards and control of samples...
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27864740/expression-levels-of-warburg-effect-related-micrornas-correlate-with-each-other-and-that-of-histone-deacetylase-enzymes-in-adult-hematological-malignancies-with-emphasis-on-acute-myeloid-leukemia
#12
Zsuzsanna Gaál, Éva Oláh, László Rejtő, Bálint László Bálint, László Csernoch
Disruption of epigenetic regulation and characteristic metabolic alterations (known as the Warburg-effect) are well-known hallmarks of cancer. In our study we investigated the expression levels of microRNAs and histone deacetylase enzymes via RT-qPCR in bone marrow specimens of adult patients suffering from hematological malignancies (total cohort n = 40), especially acute myeloid leukemia (n = 27). The levels of the three examined Warburg-effect related microRNAs (miR-378*, miR-23b, miR-26a) positively correlated with each other and the oncogenic miR-155 and miR-125b, while negatively with the level of the tumorsuppressor miR-124...
January 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27845539/review-of-clinical-uncertainty-in-primary-care-the-challenge-of-collaborative-engagement
#13
Jeffrey M Ring
Reviews the book, Clinical Uncertainty in Primary Care: The Challenge of Collaborative Engagement edited by Lucia Siegel Sommers and John Lautner (see record 2013-30484-000). The bulk of this book comprises a wide array of different models for collaborative uncertainty work. From Balint groups that help participants to tolerate uncertainty to narrative-based supervision that poses challenging self-reflective questions, each chapter provides a description of group intervention design, theoretical context, the structure for facilitation, and outcome data on impact...
March 2016: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/27796427/is-hysterectomy-or-prior-reconstructive-surgery-associated-with-unsuccessful-initial-trial-of-pessary-fitting-in-women-with-symptomatic-pelvic-organ-prolapse
#14
Zoltan Nemeth, Nelli Farkas, Balint Farkas
INTRODUCTION AND HYPOTHESIS: There is little data in the literature regarding the feasibility and limitations of pessary therapy after pelvic reconstructive surgery for symptom recurrence for treating urinary incontinence. Hysterectomy is an important risk factor for failure of pessary fitting. We aimed to evaluate the influence of these prior surgeries on subsequent initial trials of fitting a pessary. METHODS: Six hundred and twenty-nine women with symptomatic pelvic organ prolapse (POP) were included in a prospective cohort study from January 2014 to December 2015...
October 28, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27776171/analysis-of-research-activity-in-gastroenterology-pancreatitis-is-in-real-danger
#15
Andrea Szentesi, Emese Tóth, Emese Bálint, Júlia Fanczal, Tamara Madácsy, Dorottya Laczkó, Imre Ignáth, Anita Balázs, Petra Pallagi, József Maléth, Zoltán Rakonczay, Balázs Kui, Dóra Illés, Katalin Márta, Ágnes Blaskó, Alexandra Demcsák, Andrea Párniczky, Gabriella Pár, Szilárd Gódi, Dóra Mosztbacher, Ákos Szücs, Adrienn Halász, Ferenc Izbéki, Nelli Farkas, Péter Hegyi
OBJECTIVE: Biomedical investment trends in 2015 show a huge decrease of investment in gastroenterology. Since academic research usually provides the basis for industrial research and development (R&D), our aim was to understand research trends in the field of gastroenterology over the last 50 years and identify the most endangered areas. METHODS: We searched for PubMed hits for gastrointestinal (GI) diseases for the 1965-2015 period. Overall, 1,554,325 articles were analyzed...
2016: PloS One
https://www.readbyqxmd.com/read/27756679/pre-registration-efficacy-study-of-a-novel-marker-vaccine-against-classical-swine-fever-on-maternally-derived-antibody-positive-mda-target-animals
#16
A Farsang, R Lévai, T Barna, K Fábián, S Blome, K Belák, Á Bálint, F Koenen, G Kulcsár
Maternally Derived Antibodies (MDA) can have a negative effect on the efficacy of live attenuated vaccines against classical swine fever (CSF). For this reason, a marker vaccine candidate CP7_E2alf was tested for its efficacy in the presence of MDA. Pregnant sows were vaccinated four weeks before farrowing with CSF virus (CSFV) strain "Thiverval". A total of 40 piglets with MDAs were included in this study. At six weeks of age the piglets were allocated into three treatment groups using generalized randomized block design (GRBD) blocking on serological status and pen location...
January 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/27748074/preliminary-definitions-for-the-sonographic-features-of-synovitis-in-children
#17
Johannes Roth, Viviana Ravagnani, Marina Backhaus, Peter Balint, Alessandra Bruns, George A Bruyn, Paz Collado, Lorenia De la Cruz, Severine Guillaume-Czitrom, Troels Herlin, Cristina Hernandez, Annamaria Iagnocco, Sandrine Jousse-Joulin, Stefano Lanni, Vibke Lilleby, Clara Malattia, Silvia Magni-Manzoni, Consuelo Modesto, Ana Narrodi, Juan-Carlos Nieto, Sarah Ohrndorf, Linda Rossi, Anne-Marit Selvaag, Nanno Swen, Tracy Ting, Nikolay Tzaribachev, Patricia Vega-Fernandez, Jelena Vojinovic, Daniel Windschall, Maria-Antonietta D'Agostino, Esperanza Naredo
Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first. The aim of this study was to develop and validate these definitions through an international consensus process. Methods The decision on which US techniques to use, the components to be included in the definitions as well as the final wording were developed by 31 ultrasound experts in a consensus process...
October 16, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27722643/dinuclear-clathrochelate-complexes-with-pendent-cyano-groups-as-metalloligands
#18
Mathieu Marmier, Giacomo Cecot, Anna V Vologzhanina, José L Bila, Ivica Zivkovic, Henrik M Ronnow, Balint Nafradi, Euro Solari, Philip Pattison, Rosario Scopelliti, Kay Severin
Dinuclear clathrochelate complexes with two, three, four, or five cyano groups in the ligand periphery were prepared following two distinct synthetic strategies: (a) zinc(ii)- or cobalt(ii)-templated polycondensation reactions of CN-functionalized arylboronic acids and phenoldioximes, or (b) postsynthetic cross-coupling reactions of polybrominated zinc(ii) clathrochelates with 4-cyanophenylboronic acid. The new clathrochelate complexes were used as metalloligands for the construction of heterometallic Zn(2+)/Ag(+) and Co(2+)/Ag(+) coordination polymers (CPs), which were characterized by single crystal X-ray diffraction and FT-IR...
October 4, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27714586/fcg-flipi-charlson-comorbidity-index-and-histological-grade-score-is-superior-to-flipi-in-advanced-follicular-lymphoma
#19
Biljana Mihaljevic, Jelena Jelicic, Bosko Andjelic, Darko Antic, Olivera Markovic, Ivan Petkovic, Maja Perunicic Jovanovic, Goran Trajkovic, Jelena Bila, Vladislava Djurasinovic, Aleksandra Sretenovic, Vojin Vukovic, Mihailo Smiljanic, Milena Todorovic Balint
The Follicular Lymphoma International Prognostic Index (FLIPI) is widely used in the identification of risk groups among follicular lymphoma (FL) patients. The aim of the present study was to evaluate the prognostic value of FLIPI combined with the Charlson comorbidity index (CCI) and histological grade of lymphoma. 224 newly diagnosed FL patients (median age 56 years) treated with immunochemotherapy were retrospectively analysed. Low FLIPI had 21.0 % of patients, intermediate 28.1 % and high 46.9 %. 50...
December 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27711604/bifurcated-dissociative-photoionization-mechanism-of-acetic-acid-anhydride-revealed-by-imaging-photoelectron-photoion-coincidence-spectroscopy
#20
Krisztina Voronova, Chrissa M Mozaffari Easter, Krisztián G Torma, Andras Bodi, Patrick Hemberger, Bálint Sztáray
The fragmentation processes of internal energy selected acetic acid anhydride cations, Ac2O(+), were investigated by imaging photoelectron photoion coincidence (iPEPICO) spectroscopy. The first dissociation channel leads to the formation of CH3C(O)OCO(+) (m/z = 87) by a CH3-loss. The 0 K appearance energy (E0) was determined to be 10.289 ± 0.010 eV, in excellent agreement with the G4-calculated 10.28 eV transition state (TS) energy. Based on the thermochemical onset of CH3C(O)OCO(+), a reverse barrier of 40 kJ mol(-1) was found...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
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