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Nasal polyposis

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https://www.readbyqxmd.com/read/29928924/navigate-ii-randomized-double-blind-trial-of-the-exhalation-delivery-system-with-fluticasone-eds-flu-for-nasal-polyposis
#1
Donald A Leopold, David Elkayam, John C Messina, Colette Kosik-Gonzalez, Per G Djupesland, Ramy A Mahmoud
BACKGROUND: Chronic rhinosinusitis (CRS) is common and sometimes complicated by nasal polyps (NP). Corticosteroid nasal sprays are often unsatisfactory because they are ineffective at delivering medication to high/deep sites of inflammation. OBJECTIVE: Assess whether an exhalation delivery system with fluticasone (EDS-FLU), capable of high/deep drug deposition, improves outcomes. METHODS: Patients (N=323) ≥18 years with moderate-to-severe congestion and NP were randomized to twice-daily EDS-FLU (93, 186, or 372μg) or EDS-placebo for 24 weeks (16 double-blind [DB] plus 8 open-label [OL] when all received 372μg)...
June 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29901280/role-of-toll-like-receptor-9-signaling-on-activation-of-nasal-polyp-derived-fibroblasts-and-its-association-with-nasal-polypogenesis
#2
Soo Kyoung Park, Soung Yong Jin, Sun Hee Yeon, Sung Bok Lee, Jun Xu, Young Hoon Yoon, Ki Sang Rha, Yong Min Kim
BACKGROUND: Nasal polyposis is characterized by persistent inflammation and remodeling in sinonasal mucosa. Toll-like receptor 9 (TLR9) is a DNA receptor of the innate immune system that plays a pivotal role in fibrosis and inflammatory responses. The aim of this study is to explore the expression, activity, and potential pathogenic role of TLR9 signaling in tissue remodeling in nasal polyp-derived fibroblasts (NPDFs). METHODS: Fibrotic and inflammatory responses elicited by type A CpG oligonucleotides were examined in the NPDFs by a combination of real-time quantitative polymerase chain reaction, Western blot analysis, enzyme-linked immunosorbent assay, and immunofluorescence staining...
June 14, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29890239/a-trial-of-p2y-12-receptor-inhibition-with-prasugrel-identifies-a-potentially-distinct-endotype-of-patients-with-aspirin-exacerbated-respiratory-disease
#3
Tanya M Laidlaw, Katherine N Cahill, Juan Carlos Cardet, Katherine Murphy, Jing Cui, Brittney Dioneda, Parul Kothari, Benjamin A Raby, Elliot Israel, Joshua Boyce
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, recurrent nasal polyposis, and respiratory reactions upon ingestion of cyclooxygenase-1 inhibitors. Increased numbers of platelet-leukocyte aggregates are present in the sinus tissue and blood of patients with AERD, compared to aspirin-tolerant patients, and platelet activation may contribute to aspirin-induced reactions. OBJECTIVE: We sought to determine whether treatment with prasugrel, which inhibits platelet activation by blocking the P2Y12 receptor, would attenuate the severity of sinonasal and respiratory symptoms induced during aspirin challenge in subjects with AERD...
June 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29887213/updating-nasalisation-from-concept-to-technique-and-results
#4
R Jankowski, C Rumeau, D T Nguyen, P Gallet
Nasalisation is a surgical technique proposed for the treatment of nasal polyposis in 1995. The technique as initially described was based on large opening of the maxillary, sphenoidal and frontal ostia and resection of the middle turbinates, with the aim of resecting the mucosa of the lateral masses of the ethmoid as completely and safely as possible. Recent findings on the evolution and development of the nose and sinuses and sinus physiology allow both the concept and the technique of nasalisation to be updated...
June 7, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29883049/accessory-maxillary-ostium-repair-using-middle-turbinate-flap-a-case-series-of-116-patients-with-chronic-rhinosinusitis
#5
Matti Penttilä
BACKGROUND: The ostiomeatal complex (OMC), comprising a small natural maxillary sinus ostium and narrow infundibulum, transmits the air diffusion into the antrum and mucociliary transport from the antrum, and is considered a key area in chronic rhinosinusitis (CRS). Thin membranous anterior and posterior fontanelle areas below the OMC can rupture forming a perforation, accessory maxillary ostium (AMO), that increases antral airflow changing the anatomy and function of the sinus. The purpose of this study was to report the first case series of CRS patients who had undergone repair of fontanelle defects aiming to reconstruct normal structures...
June 8, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29876328/evaluating-the-effect-of-endoscopic-sinus-surgery-on-laryngeal-mucosa-stroboscopic-features
#6
Ebrahim Karimi, Akbar Bayat, Mohammad Reza Ghahari, Sara Rahavi-Ezabadi, Mehrdad Jafari
Introduction: The major presenting symptom of nasal polyps is nasal obstruction. The role of nasal obstruction in the genesis of laryngeal disorders is still unknown. Materials and Methods: The aim of this study was to evaluate laryngeal videostroboscopic changes after functional endoscopic sinus surgery (FESS) in patients with nasal polyposis. A longitudinal study was carried out from March 2012 to June 2013. Thirty patients with bilateral nasal polyposis who did not respond to maximum medical treatment and were candidates for FESS were recruited...
May 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29849780/aberrant-expression-of-mir-663-and-transforming-growth-factor-%C3%AE-1-in-nasal-polyposis-in-children
#7
Hailing Yu, Jianbao Ju, Jingdong Liu, Da Li
The aim of the present study was to investigate the expression of microRNA (miR)-663 and its regulatory effects on the pathogenesis of nasal polyposis in children. Nasal polyp tissue, as well as serum and peripheral blood eosinophils were collected from 35 children diagnosed with nasal polypectomy between August 2013 and August 2015. As a control, the inferior nasal concha, serum and peripheral blood eosinophils were collected from 46 patients with nasal septal deviation complicated by inferior turbinate hypertrophy or patients with simple inferior turbinate hypertrophy who had undergone surgical removal of the inferior nasal concha...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29785413/multivariate-analysis-of-inflammatory-endotypes-in-recurrent-nasal-polyposis-in-a-chinese-population
#8
B Wei, F Liu, J Zhang, Y Liu, J Du, S Liu, N Zhang, C Bachert, J Meng
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) remains a challenging clinical problem due to its propensity for recurrence. However, data on the frequency of CRSwNP recurrence after surgery in China are rare. METHODS: 78 CRSwNP patients undergoing functional endoscopic sinus surgery were followed-up for 8 years and classified into recurrent and non-recurrent groups. A cluster analysis of the CRSwNP based on inflammatory endotypes was performed, and the endotypes were secondarily matched with clinical phenotypes...
May 22, 2018: Rhinology
https://www.readbyqxmd.com/read/29781561/the-clinical-characteristics-and-histopathological-features-of-chronic-rhinosinusitis-with-unilateral-nasal-polyps-in-136-patients-in-southern-china
#9
Zhuo Chen, Yang Peng, Chew Lip Ng, Peng Jin, Jing Liu, Ying Ying Li, Yan Yan, Yan Hui Liu, Xin Lan Luo, Qian Hui Qiu, De Yun Wang
Based on the presence of nasal polyps (NP) on endoscopy, chronic rhinosinusitis (CRS) has been clinically divided into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). While the majority of cases are bilateral, NPs can present unilaterally. CRS with unilateral NP (UNP) is the most common presentation in unilateral polyposis, but there have been few studies on UNP. Lee et al have shown that UNP had more favorable objective surgical outcomes than bilateral disease. This article is protected by copyright...
May 21, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29764007/anesthetic-considerations-during-surgical-intervention-in-woake-s-syndrome-a-case-report
#10
So Ron Choi, Jeong Ho Kim, Kyoung Lin Chae, Seung Cheol Lee, Sang Yoong Park
Woake's syndrome (WS) is a recurrent nasal polyposis, accompanied by broadening of the nose, frontal sinus aplasia, dyscrinia, and bronchiectasis. There has been no previous report on anesthetic management in patients with WS. We describe a case involving a 13-year-old male patient with WS who was scheduled for septorhinoplasty for necrotic ethmoiditis. Anesthesia was induced and maintained with propofol and remifentanil using a target-controlled infusion device. The anesthetic considerations of this rare syndrome and the advantages of an intravenous infusion method over local and volatile anesthesia for these patients are discussed...
May 15, 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29759032/tim-3-expressing-mast-cells-are-present-in-chronic-rhinosinusitis-with-nasal-polyps
#11
Erica Corredera, Binh L Phong, John A Moore, Lawrence P Kane, Stella E Lee
Objectives To identify whether TIM-3 expression is present in the mast cell population within nasal polyps and to determine its correlation with clinical severity in patients with chronic rhinosinusitis with nasal polyposis. Study Design Basic science, translational study. Setting Nasal polyp tissue collected from patients seen at a tertiary care hospital (2015-2016). Subjects and Methods Nasal polyp tissue obtained during functional endoscopic sinus surgery (n = 24) was enzymatically digested into epithelial and stromal fractions...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29744065/emergence-of-nasal-chondrosarcoma-in-a-dog-with-nasal-polyposis
#12
Judd A Sumner, Adrian I Witham, Andrew W Stent, Paul F Wightman, Caroline S Mansfield
Whilst the malignant transformation of nasal polyps or secondary development of nasal neoplasia after chronic inflammation is likely to be relatively rare, this potential complication should be considered, and the clinician should be vigilant for evidence of malignant transformation.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29712509/systematic-review-and-meta-analysis-of-snot-22-outcomes-after-surgery-for-chronic-rhinosinusitis-with-nasal-polyposis
#13
Phong T Le, Zachary M Soler, Rabun Jones, Jose L Mattos, Shaun A Nguyen, Rodney J Schlosser
Objective Wide variation exists regarding reported outcomes after endoscopic sinus surgery (ESS) for chronic rhinosinusitis with nasal polyps (CRSwNP). This study seeks to combine data across studies to generate a summary measure and explore factors that might lead to variation. Data Sources OVID Medline, Scopus, EbscoHost, Database of Abstracts and Reviews of Effects, Health Technology Assessment, and National Health Service Economic Evaluation Database. Review Methods A search was performed following the PRISMA guidelines...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29682983/long-term-clinical-outcomes-of-aspirin-desensitization-with-continuous-daily-aspirin-therapy-in-aspirin-exacerbated-respiratory-disease
#14
Kristen M Walters, Jeremy D Waldram, Katharine M Woessner, Andrew A White
Background Aspirin-exacerbated respiratory disease (AERD), also known as Samter's triad or aspirin (ASA)-intolerant asthma, affects 7% of asthmatics and has a higher prevalence in those with chronic rhinosinusitis and concomitant nasal polyposis. ASA desensitization with daily ASA therapy is a uniquely beneficial treatment for this disease entity and has been shown to have a significant impact on symptom scores, polyp disease, and need for systemic corticosteroids. However, no long-term studies have demonstrated whether or not ASA therapy remains safe and beneficial for these patients beyond 5-10 years...
April 23, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29670184/wogonin-attenuates-nasal-polyp-formation-by-inducing-eosinophil-apoptosis-through-hif-1%C3%AE-and-survivin-suppression
#15
Roza Khalmuratova, Mingyu Lee, Ji-Hun Mo, YunJae Jung, Jong-Wan Park, Hyun-Woo Shin
Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is an inflammatory sinonasal disorder characterized by eosinophilic inflammation and T-helper 2 skewing. Eosinophil accumulation in sinonasal mucosa comprises a major feature of CRSwNP. The study aimed to investigate the effect of the flavone wogonin in nasal polyposis by assessing its ability to induce eosinophil apoptosis in vitro and attenuate eosinophilic CRSwNP in mice. Double immunofluorescence, immunohistochemistry, flow cytometry, and immunoblotting were performed to evaluate hypoxia-inducible factor (HIF)-1α, survivin, and apoptotic markers in the human eosinophilic EoL-1 cell line or sinonasal tissues from patients with CRS with or without NPs...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29661611/nasal-polyposis-or-chronic-olfactory-rhinitis
#16
R Jankowski, C Rumeau, P Gallet, D T Nguyen
The concept of chronic rhinosinusitis with or without polyps is founded on the structural and functional unicity of the pituitary mucosa and its united response to environmental aggression by allergens, viruses, bacteria, pollution, etc. The present review sets this concept against the evo-devo three-nose theory, in which nasal polyposis is distinguished as specific to the olfactory nose and in particular to the non-olfactory mucosa of the ethmoid, which is considered to be not a sinus but rather the skull-base bone harboring the olfactory mucosa...
June 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29625668/is-there-a-link-between-nasal-polyposis-and-increased-risk-for-sinonasal-malignancy
#17
Deena Pourang, Michael Batech, Kian Karimi, Javed Sheikh, Shefali Samant
No abstract text is available yet for this article.
April 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29611776/last-station-in-the-eosinophilic-asthma-with-chronic-rhinosinusitis-and-or-nasal-polyposis-march-eosinophilic-asthma-with-radiological-findings-associated-with-blood-eosinophilia
#18
Insu Yılmaz, Sakine Nazik Bahçecioğlu, Murat Türk, Nuri Tutar, Fatma Sema Oymak, İnci Gülmez
OBJECTIVE: Eosinophilic asthma with chronic rhinosinusitis and/or nasal polyposis (EA-CRS/NP) is a subphenotype of adult-onset eosinophilic asthma. Blood eosinophil levels are shown to be highly elevated in patients with EA-CRS/NP and have potential for tissue infiltration. We aimed to demonstrate the clinical features of the patients who have a blood eosinophil level above 10% and have thorax computed tomography findings due to blood eosinophilia. METHODS: Patients who were followed up in our clinic between 2012 and 2017 were retrospectively evaluated...
April 3, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29611440/new-biologics-for-allergic-diseases
#19
Laurie A Manka, Michael E Wechsler
Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biologic medications targeting many steps of the inflammatory pathways. Areas covered: There are 2 major inflammatory pathways that drive allergic diseases: Type-2 (Th-2) inflammation and non-type 2 inflammation...
April 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29601150/comparing-the-efficacy-of-silastic-and-gloved-merocel-middle-meatal-spacers-for-functional-endoscopic-sinus-surgery-a-randomized-controlled-trial
#20
Jamil Manji, Al-Rahim R Habib, Luis Macias-Valle, Andres Finkelstein, Saad Alsaleh, Anali Dadgostar, Fahad Al-Asousi, Christopher Okpaleke, Amin R Javer
BACKGROUND: Spacers are inserted into the middle meatal space (MMS) following functional endoscopic sinus surgery (FESS) to prevent lateralization of the middle turbinate, scarring, and synechiae. Our objective was to determine if the incidence of postoperative synechiae, facial pain/discomfort, pain during spacer removal, scarring, and discharge differed between nasal cavities receiving Silastic or gloved-Merocel (GM) spacers following FESS. METHODS: A double-blind, randomized controlled trial (RCT) was conducted in adults requiring bilateral FESS for chronic rhinosinusitis (CRS) ± nasal polyposis...
March 30, 2018: International Forum of Allergy & Rhinology
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