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Nasal polyposis

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https://www.readbyqxmd.com/read/29236276/5-ht7-receptors-are-over-expressed-in-patients-with-nasal-polyps
#1
Muhammed Yayla, Zekai Halici, Duygu Kose, Arzu Tatar, Mustafa Sitki Gozeler
Nasal polyposis (NP) is an inflammatory disease of the paranasal sinuses and nasal cavity. The primary purpose of our study is to determine the expression of 5-HT7 receptors both in nasal polyps and in healthy tissue in the nasal cavity. The subsequent aim is to compare the expression of 5-HT7 receptors in patients with NP and in inferior turbinate tissue (control). The study included 60 participants (40 with NP and 20 controls) aged 35 to 62 years. Nasal polyp samples were collected from all patients and relative 5-HT7 receptor expression analyses were performed...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29229196/impact-of-allergy-on-phenotypic-and-endotypic-profiles-of-nasal-polyposis
#2
G Mortuaire, I Gengler, M Balden, M Capron, G Lefèvre
OBJECTIVES: To assess the impact of allergy on clinical presentations (phenotypes) and inflammatory patterns (endotypes) of chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: A single-center prospective study was conducted over an 18-month period. Fifty-seven patients with refractory CRSwNP were included. The diagnosis of allergy was based on concordant skin prick tests and symptoms. Phenotypes were determined on symptom severity score, polyp size classification and Lund-Mackay CT staging...
December 8, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29214756/serum-cytokine-profile-in-patients-with-chronic-rhinosinusitis-with-nasal-polyposis-infected-by-aspergillus-flavus
#3
Gargi Rai, Mohammad Ahmad Ansari, Sajad Ahmad Dar, Shyama Datt, Neelima Gupta, Sonal Sharma, Shafiul Haque, Vishnampettai Ganapathysubramanian Ramachandran, Arpeeta Mazumdar, Shivprakash Rudramurthy, Arunaloke Chakrabarti, Shukla Das
BACKGROUND: Fungi, especially Aspergillus flavus, can cause chronic rhinosinusitis with nasal polyposis and modulate host innate immune components. The objective of this study was to examine the serum levels of T helper (Th) cell subset Th1, Th2, and Th17 cytokines and total IgE in patients having chronic rhinosinusitis with nasal polyposis and Aspergillus flavus infection. METHODS: A case-control study including 40 patients with chronic rhinosinusitis with nasal polyposis and 20 healthy controls was conducted...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29210519/air-pollutants-may-be-environmental-risk-factors-in-chronic-rhinosinusitis-disease-progression
#4
Leila J Mady, Hannah L Schwarzbach, John A Moore, Robert M Boudreau, Thomas J Willson, Stella E Lee
BACKGROUND: Little is known about the role of environmental exposures in the pathophysiology of chronic rhinosinusitis (CRS). In this study, we measured the impact of air pollutants (particulate matter 2.5 [PM2.5 ] and black carbon [BC]) on CRS with nasal polyposis (CRSwNP) and CRS without nasal polyposis (CRSsNP). METHODS: Spatial modeling from pollutant monitoring sites was used to estimate exposures surrounding residences for patients meeting inclusion criteria (total patients, n = 234; CRSsNP, n = 96; CRSwNP, n = 138)...
December 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29193105/correlations-between-cystic-fibrosis-genotype-and-sinus-disease-severity-in-chronic-rhinosinusitis
#5
Waleed M Abuzeid, Changeun Song, Judd H Fastenberg, Christina H Fang, Noel Ayoub, Elina Jerschow, Paul K Mohabir, Peter H Hwang
OBJECTIVE: Cystic fibrosis (CF) patients commonly develop chronic rhinosinusitis (CRS). The impact of the most common cystic fibrosis transmembrane conductance regulator (CFTR) mutation, F508del, on the severity of sinonasal disease remains inconclusive. The objective of this study is to evaluate the impact of CFTR genotype functional classification on sinonasal disease severity in patients with CRS. METHODS: Retrospective chart review of patients with CF who underwent endoscopic sinus surgery for chronic rhinosinusitis from 1998 to 2015...
November 29, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29192331/are-neutrophil-platelet-and-eosinophil-to-lymphocyte-ratio-and-red-blood-cell-distribution-width-can-be-used-for-nasal-polyposis
#6
Ahmet Kara, Mehmet Guven, Mahmut Sinan Yilmaz, Deniz Demir, Halil Elden
INTRODUCTION: The aim of this study is to explore the relationship of neutrophil, platelet and eosinophil-to-lymphocyte ratios and red blood cell distribution width values with nasal polyposis, and whether this could be a predictive parameter that can be used for the severity and recurrence risk of the disease. METHOD: Neutrophil/lymphocyte, platelet/lymphocyte, eosinophil/lymphocyte ratios and red blood cell distribution width values were compared between nasal polyposis patients who were reviewed in a retrospective manner and the control group comparable for age and sex...
November 30, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29178954/the-effectiveness-of-topical-colloidal-silver-in-recalcitrant-chronic-rhinosinusitis-a-randomized-crossover-control-trial
#7
John R Scott, Rohin Krishnan, Brian W Rotenberg, Leigh J Sowerby
BACKGROUND: Recalcitrant chronic rhinosinusitis without polyposis (CRSsP) is a challenging condition to manage as traditional medical therapies and surgery fail to provide satisfactory clinical improvements. Colloidal silver (CS), a widely used naturopathic agent, has recently shown anti-biofilm properties both in vitro and within a rhinosinusitis animal model. To date, no trials involving humans have been published in world literature. The purpose of this study was to assess the efficacy of CS as a topical nasal spray in patients with refractory CRSsP...
November 25, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29150349/frontal-sinus-revision-rate-after-nasal-polyposis-surgery-including-frontal-recess-clearance-and-middle-turbinectomy-a-long-term-analysis
#8
Hakim Benkhatar, Idir Khettab, Philippe Sultanik, Ollivier Laccourreye, Pierre Bonfils
OBJECTIVE: To determine the frontal sinus revision rate after nasal polyposis (NP) surgery including frontal recess clearance (FRC) and middle turbinectomy (MT), to search for predictive factors and to analyse surgical management. METHODS: Longitudinal analysis of 153 patients who consecutively underwent bilateral sphenoethmoidectomy with FRC and MT for NP with a minimum follow-up of 7 years. Decision of revision surgery was made in case of medically refractory chronic frontal sinusitis or frontal mucocele...
November 14, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29149827/therapeutic-applications-of-capsaicin-in-upper-airways
#9
Carlo Cavaliere, Simonetta Masieri, Franco Cavaliere
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is the substance responsible of the irritation caused by the contact of chili peppers with the skin or mucous membranes. This protoalkaloid acts by stimulating the transient receptor potential cation channel subfamily V member 1 (TRPV1), which is mainly expressed by nociceptive fibers of peripheral sensory neurons, but is also present in the central nervous system, and in some non-neuronal cells. Following the initial, intense neuronal excitation, a brief refractory period occurs...
November 17, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29131072/il-21-is-increased-in-nasal-polyposis-and-after-stimulation-with-staphylococcus-aureus-enterotoxin-b
#10
Lien Calus, Lara Derycke, Melissa Dullaers, Thibaut Van Zele, Natalie De Ruyck, Claudina Pérez-Novo, Gabriele Holtappels, Geert De Vos, Bart N Lambrecht, Claus Bachert, Philippe Gevaert
BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is an inflammatory disease associated with lymphoid aggregates and local IgE production related to Staphylococcus aureus enterotoxins. T-follicular helper cells and their effector cytokine interleukin (IL)-21 play an important role in germinal center proliferation. METHODS: IL-21 was determined on the mRNA level by qPCR in nasal tissue of 3 groups of patients: control (n = 17), chronic rhinosinusitis without nasal polyposis (CRSsNP; n = 23), and CRSwNP (n = 35)...
November 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29122084/vitamin-d%C3%A2-deficiency-and-its-association-with-nasal-polyposis-in-patients-with-cystic-fibrosis-and-patients-with-chronic-rhinosinusitis
#11
Iordanis Konstantinidis, Maria Fotoulaki, Ioannis Iakovou, Angelos Chatziavramidis, Vasilios Mpalaris, Kseniya Shobat, Konstantinos Markou
BACKGROUND: Currently vitamin D3 (VD3) or cholecalciferol is considered an immunomodulator that may be implicated in nasal polyposis (NP) pathophysiology. OBJECTIVES: This study aimed to investigate if deficiency of VD3 is associated with the presence of NP in patients with cystic fibrosis (CF) and patients with chronic rhinosinusitis (CRS). METHODS: In total, 152 adult participants were included in five phenotypic groups: CF with NP (CFwNP) (n = 27), CF without NP (CFsNP) (n = 31), CRS with NP (CRSwNP) (n = 32), CRS without NP (CRSsNP) (n = 30), and controls (n = 32)...
November 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29095709/the-role-of-frontal-sinus-drillouts-in-nasal-polyposis
#12
Carolyn A Orgain, Richard J Harvey
PURPOSE OF REVIEW: Historically, the common frontal sinusotomy has been reserved only for salvage frontal sinus surgery in patients with severely recalcitrant inflammatory sinus disease. By understanding the pathophysiology of inflammatory sinus disease and the long-term role of topical medication in their treatment, the indications for Draf3 have expanded. RECENT FINDINGS: A major therapeutic impact from endoscopic sinus surgery for inflammatory sinus disease is imparted by allowing sinus access to topical therapies to work...
October 31, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29094071/clinical-chronic-rhinosinusitis-outcomes-in-pediatric-patients-with-cystic-fibrosis
#13
REVIEW
Frank W Virgin
Objectives: Chronic rhinosinusitis and nasal polyposis are common conditions in cystic fibrosis (CF). Approximately 2-3% of pediatric CF patients per year have sinus disease requiring surgery. It has been well established that there is a significant negative impact on quality of life associated with chronic rhinosinusitis (CRS) in the non-CF patient population. However, the impact of CRS on the pediatric CF population remains uncertain. The purpose of this article is to review the current state of outcome measures for CRS in pediatric CF patients...
October 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29094070/course-of-olfaction-after-sinus-surgery-for-chronic-rhinosinusitis
#14
Boris R Haxel, Patrick Boessert, Veronika Weyer-Elberich, Kai Fruth
Background: The influence of surgery on olfaction in patients who suffer from chronic rhinosinusitis (CRS) is still not fully understood. Most particularly, the time course of the recovery is poorly studied. Methods: The prospective study describes the results of the Sniffin' Sticks identification test in 41 subjects before (V1), 2 weeks after (V2), and 6 months after (V3) endonasal sinus surgery (ESS). Influencing factors (gender, revision surgery, nasal polyposis, and initial olfactory score) on the changes of the smell testing were evaluated...
October 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29076871/olfactory-epithelial-hamartoma-a-new-subtype-of-sinonasal-hamartoma
#15
Myriam Kossai, Sophie El Zein, Michel Wassef, Jean-Pierre Guichard, Christelle Pouliquen, Philippe Herman, Benjamin Vérillaud, Marion Classe
Sinonasal epithelial hamartomas occurring in adults are classified as seromucinous hamartoma (SMH) or respiratory epithelial adenomatoid hamartoma (REAH). We describe herein a novel subtype of adult sinonasal hamartoma that contains olfactory epithelium, a histologic feature not previously reported in the literature. Our pathology department database was retrospectively searched for sinonasal hamartomas containing areas of olfactory epithelium. Six relevant cases (3 male and 3 female patients; age, 30 to 77 y) were retrieved, and available pathology slides and clinical and imaging data from patient charts were reviewed...
October 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29072882/rita-the-italian-severe-uncontrolled-asthma-registry
#16
Sara Maio, Sandra Baldacci, Megon Bresciani, Marzia Simoni, Manuela Latorre, Nicola Murgia, Fabrizio Spinozzi, Mariachiara Braschi, Leonardo Antonicelli, Barbara Brunetto, Patrizia Iacovacci, Paolo Roazzi, Carlo Pini, Mario Pata, Lidia La Grasta, Pierluigi Paggiaro, Giovanni Viegi
BACKGROUND: The Italian severe/uncontrolled asthma (SUA) web-based registry encompasses demographic, clinical, functional, inflammatory data; it aims to raise SUA awareness, identifying specific phenotypes and promoting optimal care. METHODS: 493 adult patients from 27 Italian centres (recruited in 2011-2014) were analyzed. RESULTS: Mean age was 53.8yrs. SUA patients were more frequently female (60.6%), with allergic asthma (83.1%). About 30% showed late onset of asthma diagnosis/symptoms (>40yrs); the mean age for asthma symptoms onset was 30...
October 26, 2017: Allergy
https://www.readbyqxmd.com/read/29070271/characterization-of-t-cell-subpopulations-in-patients-with-chronic-rhinosinusitis-with-nasal-polyposis
#17
Pascal Ickrath, Norbert Kleinsasser, Xin Ding, Christian Ginzkey, Niklas Beyersdorf, Rudolf Hagen, Thomas Kerkau, Stephan Hackenberg
BACKGROUND: There is an ongoing discussion concerning the potential origins of chronic rhinosinusitis with nasal polyposis (CRSwNP). OBJECTIVE: The aim of this study was to quantify subpopulations of T cells in peripheral blood and nasal polyps in CRSwNP to examine their influence on the etiology of this disease. METHODS: Tissue and blood samples were collected from 11 patients who underwent nasal sinus surgery, and these samples were analyzed by multicolor flow cytometry...
October 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/29066918/asthma-with-bronchial-hypersecretion-expression-of-mucins-and-toll-like-receptors-in-sputum-and-blood
#18
Astrid Crespo-Lessmann, Eder Mateus, Montserrat Torrejón, Alicia Belda, Jordi Giner, Silvia Vidal, Oriol Sibila, Vicente Plaza
Asthma with bronchial hypersecretion is a type of asthma that is poorly studied. Its pathogenesis is not well understood, but is probably related to innate impaired immunity, particularly with toll-like receptors (TLRs) and secretory mucins (MUC). OBJECTIVES: 1) Define the clinical and inflammatory phenotype of asthma with bronchial hypersecretion of mucus. 2) Compare the type of mucin present in induced sputum (IS) of patients with and without bronchial hypersecretion. 3) Determine the expression of TLRs in IS and blood of asthmatics with and without bronchial hypersecretion...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29050753/outcome-of-spray-cryotherapy-plus-functional-endoscopic-sinus-surgery-on-management-of-healing-in-nasal-polyposis
#19
Ahmad Rezaeian
BACKGROUND: Nasal Polyposis is a benign tumor in nasal or paranasal mucosa, which confronts difficulties in management of healing after treatments with surgery. The aim of this study was to evaluate the effects of Spray Cryotherapy (SCT) on management of healing in patients with nasal polyposis who undergone functional endoscopic sinus surgery. METHODS: In this prospective, clinical trial study, we investigated on 40 patients with nasal polyposis that had indication for functional endoscopic sinus surgery...
October 10, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29045032/a-retrospective-review-of-six-hundred-and-nineteen-cases-to-determine-the-prevalence-and-factors-associated-with-revision-endoscopic-sinus-surgery-in-afrs-vs-non-afrs-patients
#20
LETTER
A Rajwani, J Manji, A Finkelstein-Kulka, A-R R Habib, S Alsaleh, L Macias-Valle, A R Javer
No abstract text is available yet for this article.
October 17, 2017: Clinical Otolaryngology
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