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Nasal polyposis

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https://www.readbyqxmd.com/read/29453478/endoscopic-sinus-surgery-for-sinonasal-polyposis-microdebrider-or-conventional-instruments
#1
Nabin Lageju, Bibhu Pradhan, Narmaya Thapa
INTRODUCTION: Sinonasal polyposis is one of the commonest causes of nasal obstruction. Surgical management is treatment of choice. Microdebrider offers more advantage to conventional instruments. We aimed to find out outcome using microdebrider versus conventional instruments in endoscopic sinus surgery of sinonasal polyposis. METHODS: The cross sectional descriptive study carried out in patients aged 13 years and above with diagnosis of sinonasal polyposis. Total of 51 patients were operated on the right side with microdebrider and left side with conventional instruments...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29437297/snot-22-based-clusters-in-chronic-rhinosinusitis-without-nasal-polyposis-exhibit-distinct-endotypic-and-prognostic-differences
#2
Devyani Lal, Claire Hopkins, Rohit D Divekar
BACKGROUND: Endotypic and prognosticating features of chronic rhinosinusitis without nasal polyposis (CRSsNP) are poorly understood. Our objectives were to use an unbiased symptom-based approach to: (1) study symptoms, clinical and endotypic features; and (2) identify features predicating outcomes from endoscopic sinus surgery (ESS). METHODS: Clinical, computed tomography (CT), histopathology, and 22-item Sino-Nasal Outcome Test (SNOT-22) data was collected on 146 adult CRSsNP patients who underwent ESS...
February 13, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29423374/the-international-study-of-the-allergic-rhinitis-survey-outcomes-from-4-geographical-regions
#3
Desiderio Passali, Cemal Cingi, Paola Staffa, Francesco Passali, Nuray Bayar Muluk, Maria Luisa Bellussi
Background: Allergic rhinitis (AR) is a global health problem and is characterised by one or more symptoms, including sneezing, itching, nasal congestion and rhinorrhea. Objective: We investigated the features of AR and the physician's approach to the management of AR patients in four geographical regions. Methods: In this cross-sectional study, a questionnaire survey concerning AR was completed by Honorary and Corresponding Members of the Italian Society of Rhinology from different countries among 4 world geographical regions-Asia, Europe, the Americas, and Africa...
January 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29420096/gamma-globulin-replacement-therapy-in-uncontrolled-severe-asthma-associated-with-humoral-immunodeficiency-a-series-of-five-case-reports
#4
Angelica Tiotiu, Yves Martinet, Roger Jankowski, Philippe Devillier
We report on five adult cases of the rare association of asthma with humoral immunodeficiency (huID). All patients had uncontrolled asthma related to recurrent respiratory infections. Asthma was diagnosed according to the Global Initiative for Asthma (GINA) guidelines, and bronchiectasis was ruled out by a CT chest scan. Two men (aged 28 and 60) presented with pollen allergies, chronic rhinosinusitis, and IgG deficiency (7.8 and 7.6 g/L, respectively). Both patients underwent surgery for nasal polyposis but relapsed with acute sinusitis and severe asthma exacerbations requiring treatment with oral corticosteroids and antibiotics...
February 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29414455/aspirin-exacerbated-respiratory-disease-current-topics-and-trends
#5
REVIEW
José Carlos Rodríguez-Jiménez, Fernanda Judith Moreno-Paz, Luis Manuel Terán, Eduardo Guaní-Guerra
Aspirin-exacerbated respiratory disease is a chronic and treatment-resistant disease, characterized by the presence of eosinophilic rhinosinusitis, nasal polyposis, bronchial asthma, and nonsteroidal anti-inflammatory drugs hypersensitivity. Alterations in arachidonic acid metabolism may induce an imbalance between pro-inflammatory and anti-inflammatory substances, expressed as an overproduction of cysteinyl leukotrienes and an underproduction of prostaglandin E2. Although eosinophils play a key role, recent studies have shown the importance of other cells and molecules in the development of the disease like mast cells, basophils, lymphocytes, platelets, neutrophils, macrophages, epithelial respiratory cells, IL-33 and thymic stromal lymphopoietin, making each of them promissory diagnostic and treatment targets...
February 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29414449/mucus-hypersecretion-in-asthma-is-associated-with-rhinosinusitis-polyps-and-exacerbations
#6
Carlos Martínez-Rivera, Astrid Crespo, Celia Pinedo-Sierra, Juan L García-Rivero, Abel Pallarés-Sanmartín, Núria Marina-Malanda, Silvia Pascual-Erquicia, Alicia Padilla, Sagrario Mayoralas-Alises, Vicente Plaza, Antolín López-Viña, César Picado
BACKGROUND: Bronchial hypersecretion is a poorly studied symptom in asthma. The aim of the study was to determine the specific characteristics of asthmatics with bronchial hypersecretion. METHODS: A total of 142 asthmatics (21.8% men; mean age 49.8 years) were prospectively followed for one year. Mucus hypersecretion was clinically classified into two severity categories: daily sputum production and frequent expectoration but not every day. Clinical and pulmonary function variables associated with mucus hypersecretion were assessed by multiple logistic regression analysis...
February 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29412801/differentially-expressed-secretoglobin-1c1-gene-in-nasal-polyposis
#7
Sibel Özdaş, Talih Özdaş
Nasal polyps (NP) are the most common pathological change that occurs in the nasal mucosa and is characterized by mucosal inflammation. Although its etiology and pathogenesis have not been clearly explained, its pathophysiology is arranged by the balance between pro-inflammatory and anti-inflammatory cytokines. The Secretoglobin 1C1 gene synthesizes odor molecule binding proteins (OBPs) in the nasal mucosa and regulates some cytokines. The Secretoglobin 1C1 gene expression could be disrupted by polymorphisms that may act as a possible cause of a disruption in the regulation of the promotor of the gene...
January 31, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29409312/impact-and-modulations-of-peripheral-and-edaphic-b-cell-subpopulations-in-chronic-rhinosinusitis-with-nasal-polyposis
#8
Pascal Ickrath, Norbert Kleinsasser, Xin Ding, Christian Ginzkey, Niklas Beyersdorf, Thomas Kerkau, Rudolf Hagen, Stephan Hackenberg
Objectives: The pathophysiological mechanisms of chronic rhinosinusitis with nasal polyposis (CRSwNP) still are discussed controversially. Regulatory B cells (Breg) are responsible for the suppression of T cell activity: deficiencies for Breg have been demonstrated to contribute to autoimmune disorders, e.g., systemic lupus erythematosus. In order to evaluate the influence of B cell subpopulations, especially Breg, on the etiology of this disease, the aim of this study was to characterize subpopulations of peripheral and edaphic B cells in CRSwNP...
February 8, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29404165/clinical-and-serological-features-of-eosinophilic-and-vasculitic-phases-of-eosinophilic-granulomatosis-with-poliangiitis-a-case-series-of-15-patients
#9
İnsu Yılmaz, Nuri Tutar, Zuhal Özer Şimşek, Fatma Sema Oymak, İnci Gülmez
OBJECTIVES: Eosinophilic granulomatosis with poliangiitis (EGPA) which was previously called Churg-Strauss Syndrome, is classified into eosinophilic and vasculitic phases. To characterize the eosinophilic and vasculitic phases of the disease in terms of clinical findings, serology, and treatment. MATERIALS AND METHODS: We included 15 EGPA patients in the study. The clinical, serological, and therapeutic characteristics and the treatment responses of the patients were recorded...
July 2017: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29396960/monoclonal-antibodies-for-the-treatment-of-chronic-rhinosinusitis-with-nasal-polyposis-a-systematic-review
#10
N Tsetsos, J K Goudakos, D Daskalakis, I Konstantinidis, K Markou
BACKGROUND: Monoclonal antibodies have been proposed as a novel therapy in patients suffering from chronic rhinosinusitis with nasal polyposis (CRSwNP). The purpose of this systematic review was to evaluate their efficacy and safety. METHODOLOGY: A literature search was performed in MEDLINE, Web of Science, the Cochrane Library and multiple trial registries followed by extensive hand-searching for the identification of relevant studies. Only randomized controlled trials (RCTs) comparing the use of monoclonal antibodies with placebo or another therapy in adult patients with CRSwNP were included...
February 3, 2018: Rhinology
https://www.readbyqxmd.com/read/29396958/higher-prevalence-of-nasal-polyposis-among-textile-workers-an-endoscopic-based-and-controlled-study
#11
R Veloso-Teles, R Cerejeira, R Roque-Farinha, C von Buchwald
BACKGROUND: There is a deficit of reliable epidemiologic studies exploring the prevalence of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Recent data suggests that occupational dust exposure may be involved in its physiopathology. OBJECTIVES: To compare the prevalence of nasal polyposis (NP) in a group of workers with occupational dust exposure (textile workers) and in a control group (retail store workers). METHODS: Cross-sectional study with a random sample of textile and retail store employees...
February 3, 2018: Rhinology
https://www.readbyqxmd.com/read/29396682/causality-assessment-of-olfactory-and-gustatory-dysfunction-associated-with-intranasal-fluticasone-propionate-application-of-the-bradford-hill-criteria
#12
REVIEW
Chandrashekhar S Muganurmath, Amy L Curry, Andrew H Schindzielorz
Causality assessment is crucial to post-marketing pharmacovigilance and helps optimize safe and appropriate use of medicines by patients in the real world. Self-reported olfactory and gustatory dysfunction are common in the general population as well as in patients with allergic rhinitis and nasal polyposis. Intranasal corticosteroids, including intranasal fluticasone propionate (INFP), are amongst the most effective drugs indicated in the treatment of allergic rhinitis and nasal polyposis. While intranasal corticosteroids are associated with olfactory and gustatory dysfunction and are currently labeled for these adverse events, causality assessment has not been performed to date...
February 2, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29393242/focus-on-the-involvement-of-the-nose-and-paranasal-sinuses-in-eosinophilic-granulomatosis-with-polyangiitis-churg-strauss-syndrome-nasal-cytology-reveals-infiltration-of-eosinophils-as-a-very-common-feature
#13
Veronica Seccia, Chiara Baldini, Manuela Latorre, Matteo Gelardi, Iacopo Dallan, Lodovica Cristofani-Mencacci, Stefano Sellari-Franceschini, Maria Laura Bartoli, Elena Bacci, Pierluigi Paggiaro
BACKGROUND: Eosinophilic granulomatosis with polyangiitis (EGPA) is a necrotizing vasculitis that predominantly affects small- to medium-sized vessels. It is characterized by a wide spectrum of extrapulmonary symptoms, including sinonasal and paranasal sinus abnormalities. These are the most common features of this disease, constituting diagnostic criteria for EGPA. However, the actual clinical features, cellular mechanisms and impact on patients' quality of life (QoL) are still a matter of study...
January 23, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29392055/tnf-%C3%AE-and-il-1-%C3%AE-cytokine-gene-polymorphism-in-patients-with-nasal-polyposis
#14
Onur İsmi, Cengiz Özcan, Gürbüz Polat, Seval Kul, Kemal Görür, Tuğçe Pütürgeli
Objective: Nasal Polyp (NP) is a benign mass of the paranasal sinuses that protrudes into the nasal cavity. The exact underlying pathogenesis is not known. In this study we aimed to determine the genetic susceptibility of NP formation in relation to TNF-α-308 and IL-1β-511 promoter region gene polymorphisms. Methods: A total of 71 patients with NP with asthma (n=21) or without asthma (n=50) were taken as the study group, and 91 healthy volunteers were taken as the control group...
June 2017: Turkish Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29388847/the-role-of-tnf-alpha-polymorphism-and-expression-in-susceptibility-to-nasal-polyposis
#15
Guimin Zhang, Jinmei Zhang, Manbao Kuang, Peng Lin
OBJECTIVE: In this study, we first performed a meta-analysis to assess the role of single-nucleotide polymorphism (SNP) within tumor necrosis factor alpha (TNF alpha) gene and TNF alpha expression in the risk of nasal polyposis. METHODS: STATA 12.0 software was utilized to conduct the Mantel-Haenszel statistics, Cohen statistics, Begg's test, Egger's tests and sensitivity analysis. RESULTS: We systemically carried out the database retrieval and initially identified 486 articles...
February 1, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29350840/a-phase-3-trial-of-mometasone-furoate-sinus-implants-for-chronic-sinusitis-with-recurrent-nasal-polyps
#16
Robert C Kern, J Pablo Stolovitzky, Stacey L Silvers, Ameet Singh, Jivianne T Lee, David M Yen, Alfred M C Iloreta, Francis P J Langford, Boris Karanfilov, Keith E Matheny, James W Stambaugh, Anna K Gawlicka
BACKGROUND: Topical intranasal corticosteroid sprays (INCSs) are standard treatment for nasal polyps (NPs), but their efficacy is reduced by poor patient compliance and impaired access of drug to the sinus mucosa. A corticosteroid-eluting sinus implant was designed to address these limitations in patients with recurrent polyposis after sinus surgery by delivering 1350 μg of mometasone furoate (MF) directly to the ethmoid sinus mucosa over approximately 90 days. METHODS: A randomized, sham-controlled, double-blind trial was undertaken in 300 adults with refractory chronic rhinosinusitis with NPs (CRSwNP), who were candidates for repeat surgery...
January 19, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29336288/how-often-is-sinus-surgery-performed-for-chronic-rhinosinusitis-with-versus-without-nasal-polyps
#17
Elisabeth H Ference, Jeffrey D Suh, Bruce K Tan, Stephanie Shintani Smith
BACKGROUND: There currently are no data on the relative frequency of endoscopic sinus surgeries (ESS) performed for chronic rhinosinusitis with nasal polyposis (CRSwNP) versus chronic rhinosinusitis without nasal polyposis (CRSsNP) in the United States. OBJECTIVES: To compare the rate of surgical interventions for CRSwNP and CRSsNP. METHODS: Cases identified by CPT codes were extracted from the 2009-2011 State Ambulatory Surgery Databases for California, Florida, Maryland, and New York...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29336281/naive-and-effector-b-cell-subtypes-are-increased-in-chronic-rhinosinusitis-with-polyps
#18
Dijana Miljkovic, Alkis Psaltis, Peter-John Wormald, Sarah Vreugde
BACKGROUND: Recent studies demonstrated that B cells and their chemoattractants are elevated in the nasal mucosa of patients with chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP). However, the presence of naive B cells and of plasmablasts and memory B-cell subsets in the mucosa and periphery of the same patient with CRS is yet to be characterized. OBJECTIVE: Here we sought to quantify naive, plasmablasts, and memory B cells in mucosal tissue and peripheral blood of patients with CRSwNP, patients with CRS without nasal polyps (CRSsNP), and control patients...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29334431/activation-state-of-circulating-eosinophils-in-nasal-polyposis
#19
Vincent Dupuch, Arlette Tridon, Sylvie Ughetto, Stéphane Walrand, Benjamin Bonnet, Claude Dubray, Aude Virlogeux, Marie-Paule Vasson, Nicolas Saroul, Thierry Mom, Laurent Gilain, Bertrand Evrard
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease with an uncertain pathophysiology. It is characterized by polyps rich in eosinophils, with an activation status already investigated at the tissue level. In a group of CRSwNP patients, we assessed the activation status of circulating eosinophils in the blood before migration into tissues. METHODS: Thirteen patients with CRSwNP and 16 healthy volunteers were enrolled. Several biologic parameters were studied: blood count of eosinophils; plasma eosinophil cationic protein; oxidative metabolism by chemiluminescence at baseline or when activated by phorbol 12-myristate 13-acetate or platelet-activating factor, with or without interleukin-5 (IL-5); percent of granulosar cells; and mean fluorescence intensity (MFI) by flow cytometry...
January 15, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29316300/asthma-onset-pattern-and-patient-outcomes-in-a-chronic-rhinosinusitis-population
#20
Christopher Jones, Caroline P E Price, Ava R Weibman, Kevin C Welch, David B Conley, Stephanie Shintani-Smith, Whitney W Stevens, Anju T Peters, Leslie Grammer, Alcina K Lidder, Robert P Schleimer, Robert C Kern, Bruce K Tan
BACKGROUND: Chronic rhinosinusitis (CRS) is strongly associated with comorbid asthma. This study compares early-onset and late-onset asthma in a CRS population using patient-reported and clinical characteristics. METHODS: At enrollment into a clinical registry, CRS patients completed the 22-item Sino-Nasal Outcome Test (SNOT-22), Asthma Control Test (ACT), mini-Asthma Quality of Life Questionnaire (miniAQLQ), the 29-item Patient-Reported Outcomes Measurement Information System (PROMIS-29), and medication use questionnaires...
January 5, 2018: International Forum of Allergy & Rhinology
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