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https://www.readbyqxmd.com/read/29452425/clinical-evidence-on-dietary-supplementation-with-chia-seed-salvia-hispanica-l-a-systematic-review-and-meta-analysis
#1
Siew Li Teoh, Nai Ming Lai, Possatorn Vanichkulpitak, Vladimir Vuksan, Hoang Ho, Nathorn Chaiyakunapruk
Context: Chia seed is a popular dietary supplement, taken mainly for its high content of alpha-linolenic acid, vegetable protein, and dietary fiber, yet information about its clinical effects is lacking. Objective: This review aims to summarize the clinical evidence regarding the use of chia seed for a wide variety of health conditions. Data Sources: A number of databases, including PubMed and Embase, were searched systematically. Study Selection: Randomized controlled trials that assessed the clinical effects of chia seed consumption in human participants were included...
February 14, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29452395/mini-extracorporeal-circulation-technology-conventional-bypass-and-prime-displacement-in-isolated-coronary-and-aortic-valve-surgery-a-propensity-matched-in-hospital-and-survival-analysis
#2
Priyadharshanan Ariyaratnam, Lindsay A Mclean, Alexander Cale, Mubarak A Chaudhry, Ajith Vijayan, Neil Richards, Martin A Jarvis, Yama Haqzad, Dumbor Ngaage, Michael E Cowen, Mahmoud Loubani
OBJECTIVES: Conventional cardiopulmonary bypass is the most commonly used means of artificial circulation in cardiac surgery. However, it suffers from the effects of haemodilution and activation of inflammatory/coagulation cascades. Prime displacement (PD) can offset haemodilution and Mini-Extracorporeal Technology (MIECT) can offset both. So far, no study has compared all of these modalities together; hence, we compared the outcomes of these 3 modalities at our institution. METHODS: This was a retrospective analysis of our cardiac surgical database...
February 14, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29452392/pbrit-gene-prioritization-by-correlating-functional-and-phenotypic-annotations-through-integrative-data-fusion
#3
Ajay Anand Kumar, Lut Van Laer, Maaike Alaerts, Amin Ardeshirdavani, Yves Moreau, Kris Laukens, Bart Loeys, Geert Vandeweyer, Inanc Birol
Motivation: Computational gene prioritization can aid in disease gene identification. Here, we propose pBRIT (prioritization using Bayesian Ridge regression and Information Theoretic model), a novel adaptive and scalable prioritization tool, integrating Pubmed abstracts, Gene Ontology, Sequence similarities, Mammalian and Human Phenotype Ontology, Pathway, Interactions, Disease Ontology, Gene Association database and Human Genome Epidemiology database, into the prediction model.We explore and address effects of sparsity and inter-feature dependencies within annotation sources, and the impact of bias towards specific annotations...
February 14, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29452361/iui-review-and-systematic-assessment-of-the-evidence-that-supports-global-recommendations
#4
Ben Cohlen, Aartjan Bijkerk, Sheryl Van der Poel, Willem Ombelet
BACKGROUND: IUI with or without ovarian stimulation (OS) has become a first-line treatment option for many infertile couples, worldwide. The appropriate treatment modality for couples and their clinical management through IUI or IUI/OS cycles must consider maternal and perinatal outcomes, most notably the clinical complication of higher-order multiple pregnancies associated with IUI-OS. With a current global emphasis to continue to decrease maternal and perinatal mortality and morbidity, the World Health Organization (WHO) had established a multi-year project to review the evidence for the establishment of normative guidance for the implementation of IUI as a treatment to address fertility problems, and to consider its cost-effectiveness for lower resource settings...
February 14, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29452357/del-nido-cardioplegia-in-adult-cardiac-surgery-beyond-single-valve-surgery
#5
Wan Kee Kim, Hong Rae Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
OBJECTIVES: In recent years, the use of del Nido (DN) cardioplegia has been reported in single-valve surgery or isolated coronary artery bypass surgery with acceptable outcomes. The reports of its use in more complex adult cardiac procedures, however, have been scarce. METHODS: We enrolled a total of 149 adult patients who underwent heart valve surgery with the use of DN cardioplegia between May 2014 and December 2016. For a benchmark comparison, 892 patients who underwent cardiac valve surgery with blood cardioplegia during the same period served as controls...
February 14, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29452312/effects-of-higher-versus-lower-threat-contexts-on-pain-related-visual-attention-biases-an-eye-tracking-study-of-chronic-pain
#6
Todd Jackson, Lin Su, Yang Wang
In this research, we examined effects of higher versus lower threat contexts on attention biases in more and less pain-fearful chronic pain subgroups via eye-tracking methodology. Within a mixed chronic pain sample (69 women, 29 men), biases in orienting and maintenance of visual attention were assessed during the standardized image pair presentation phase (2000ms) of a modified visual dot probe task featuring painful-neutral (P-N) image pairs (lower threat context) and a parallel task in which these P-N pairs cued potential pain (higher threat context)...
February 13, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29452265/characterizing-the-modulation-of-resting-state-fmri-metrics-by-baseline-physiology
#7
Powell P W Chu, Ali M Golestani, Jonathan B Kwinta, Yasha B Khatamian, J Jean Chen
The blood-oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal is commonly used to assess functional connectivity across brain regions, particularly in the resting state (rs-fMRI). However, the BOLD fMRI signal is not merely a representation of neural activity, but a combination of neural activity and vascular response. These aspects of the BOLD signal are easily influenced by systemic physiology, potentially biasing BOLD-based functional connectivity measurements. In this work, we focus on the following physiological modulators of the BOLD signal: cerebral blood flow (CBF), venous blood oxygenation, and cerebrovascular reactivity (CVR)...
February 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29452223/grade-guidelines-19-assessing-the-certainty-of-evidence-describing-the-relative-importance-of-outcomes-or-values-and-preferences-risk-of-bias-and-indirectness
#8
Yuan Zhang, Pablo Alonso Coello, Gordon Guyatt, Juan Jose Yepes-Nunez, Elie A Akl, Glen Hazlewood, Hector Pardo-Hernandez, Itziar Etxeandia-Ikobaltzeta, Amir Qaseem, John W Williams, Peter Tugwell, Signe Flottorp, Yaping Chang, Yuqing Zhang, Reem A Mustafa, María Ximena Rojas, Holger J Schünemann
OBJECTIVE: The GRADE working group defines patient values and preferences as the relative importance patients place on the main health outcomes. We provide GRADE guidance for assessing the risk of bias and indirectness domains for certainty of evidence about the relative importance of outcomes. STUDY DESIGN AND SETTING: We applied the GRADE domains to rate the certainty of evidence in the importance of outcomes to several systematic reviews, iteratively reviewed draft guidance and consulted GRADE members and other stakeholders for feedback...
February 13, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29452202/effectiveness-of-indoor-allergen-reduction-in-the-management-of-asthma-a-systematic-review
#9
Brian F Leas, Kristen E D'Anci, Andrea J Apter, Tyra Bryant-Stephens, Marcus P Lynch, Janice L Kaczmarek, Craig A Umscheid
BACKGROUND: This review will inform updated National Asthma Education and Prevention Program clinical practice guidelines. OBJECTIVE: To evaluate the effectiveness of allergen reduction interventions on asthma outcomes. METHODS: We systematically searched the gray literature and five bibliographic databases. Eligible studies included systematic reviews, randomized controlled trials, and nonrandomized interventional studies. Risk of bias was assessed using the Cochrane Risk of Bias instrument and the Newcastle-Ottawa scale...
February 13, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29451923/to-what-extent-do-potential-conservation-donors-value-community-aspects-of-conservation-projects-in-low-income-countries
#10
Amy R Lewis, Richard P Young, James M Gibbons, Julia P G Jones
There is a major gap in funding required for conservation, especially in low income countries. Given the significant contribution of taxpayers in industrialized countries to funding conservation overseas, and donations from membership organisation, understanding the preferences of ordinary people in a high income country for different attributes of conservation projects is valuable for future marketing of conservation. We conducted a discrete choice experiment with visitors to a UK zoo, while simultaneously conducting a revealed preference study through a real donation campaign on the same sample...
2018: PloS One
https://www.readbyqxmd.com/read/29451886/which-preferences-associate-with-school-performance-lessons-from-an-exploratory-study-with-university-students
#11
Daniel Horn, Hubert Janos Kiss
Success in life is determined to a large extent by school performance so it is important to understand the effect of the factors that influence it. In this exploratory study, in addition to cognitive abilities, we attempt to link measures of preferences with outcomes of school performance. We measured in an incentivized way risk, time, social and competitive preferences and cognitive abilities of university students to look for associations between these measures and two important academic outcome measures: exam results and GPA...
2018: PloS One
https://www.readbyqxmd.com/read/29451838/serotype-distribution-of-streptococcus-pneumoniae-and-potential-impact-of-pneumococcal-conjugate-vaccines-in-china-a-systematic-review-and-meta-analysis
#12
Kaile Chen, Xiyan Zhang, Wei Shan, Genming Zhao, Tao Zhang
OBJECTIVE: Thirteen-valent pneumococcal conjugate vaccines (PCV13) was licensed for optional use in mainland China since 2017, but the uptake is low. To update the research evidence for the pneumococcal serotype distribution of pre-PCV era and to estimate the potential impact of PCVs, we performed a meta-analysis on the relevant publications concerning the Chinese population. METHODS: This systematic review and meta-analysis were conducted on the pneumococcal serotype distribution publications in mainland China from 2000 to 2016...
February 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29451828/the-effect-of-omega-3-fatty-acids-epa-and-or-dha-on-male-infertility-a-systematic-review-and-meta-analysis
#13
Banafshe Hosseini, Mahdieh Nourmohamadi, Shima Hajipour, Mohsen Taghizadeh, Zatollah Asemi, Seyed Ali Keshavarz, Sadegh Jafarnejad
The objective was to evaluate the effect of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on sperm parameters including total sperm concentration, sperm motility, sperm DHA, and seminal plasma DHA concentration in infertile men. The literature search was conducted in PubMed, Google Scholar, and Scopus from January 1, 1990 to December 20, 2017. The systematic review and meta-analysis were based on randomized controlled trials in infertile men with DHA or EPA treatments, either alone or in combination with other micronutrients...
February 16, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29451712/lipid-modifying-effects-of-chitosan-supplementation-in-humans-a-pooled-analysis-with-trial-sequential-analysis
#14
Haohai Huang, Ying Zou, Honggang Chi, Dan Liao
SCOPE: We performed a pooled analysis with trial sequential analysis (TSA) to evaluate the efficacy and safety of chitosan supplementation on serum lipids in humans. METHODS AND RESULTS: Medline, EMBASE and CENTRAL databases were queried. Impact was expressed as a weighted mean difference (WMD) and 95% confidence interval (CI). Sensitivity analysis was conducted using the leave-one-out method. Statistical heterogeneity, publication bias, TSA and subgroup analyses were also assessed...
February 16, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29451666/pilates-for-breast-cancer-a-systematic-review-and-meta-analysis
#15
Roberta Costa Espíndula, Gabriella Barbosa Nadas, Maria Inês da Rosa, Charlie Foster, Florentino Cardoso de Araújo, Antonio Jose Grande
INTRODUCTION: Breast cancer is the leading type of cancer causing death in women worldwide. The incidence of the disease is expected to grow worldwide due to the aging of the population and risk factors related to lifestyle behaviors. Considering the lifestyle of women with breast cancer before or after surgery, pilates exercise may be a complementary intervention additionally to standard treatment. OBJECTIVE: To analyze the efficacy of pilates compared to other exercises and to no exercise for women with breast cancer diagnosis...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29451519/-hepatitis-c-virus-infections-is-it-only-e-liver-disease
#16
Salvatore Petta
Hepatitis C virus (HCV) infection is widely diffused in general population, and the likelihood that an infected individual is affected by other disesases is high. A lot of epidemiological and explicative studies, even if with different levels of evidence, reported a potential effect of HCV infection -by direct and indirect mechanisms- on the pathogenesis of extrahepatic comorbidities related to dysregulation of the immune system, or cardiometabolic comorbidities like diabetes, neuropsychiatric disorders, chronic kidney disease, cardiovascular alterations, etc...
January 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29451414/comparing-methods-of-misclassification-correction-for-studies-of-adolescent-alcohol-use
#17
Melvin D Livingston, Brad Cannell, Keith Muller, Kelli A Komro
BACKGROUND: Despite concerns over measurement error, self-report continues to be the most common measure of adolescent alcohol use used by researchers. Objective measures of adolescent alcohol use continue to advance; however, they tend to be cost prohibitive for larger studies. By combining appropriate statistical techniques and validation subsamples, the benefits of objective alcohol measures can be made more accessible to a greater number of researchers. OBJECTIVES: To compare three easily implemented methods to correct for measurement error when objective measures of alcohol use are available for a subsample of participants, regression calibration, multiple imputation for measurement error (MIME), and probabilistic sensitivity analysis (PSA), and provide guidance regarding the use of each method in scenarios likely to occur in practice...
2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29451303/sex-specific-manifestation-of-genetic-risk-for-attention-deficit-hyperactivity-disorder-in-the-general-population
#18
Joanna Martin, Mark J Taylor, Mina Rydell, Lucy Riglin, Olga Eyre, Yi Lu, Sebastian Lundström, Henrik Larsson, Anita Thapar, Paul Lichtenstein
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is more commonly diagnosed in males than in females. A growing body of research suggests that females with ADHD might be underdiagnosed or receive alternative diagnoses, such as anxiety or depression. Other lines of reasoning suggest that females might be protected from developing ADHD, requiring a higher burden of genetic risk to manifest the disorder. METHODS: We tested these two hypotheses, using common variant genetic data from two population-based cohorts...
February 16, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29451106/thinking-in-a-foreign-language-reduces-the-causality-bias
#19
Marcos Díaz-Lago, Helena Matute
The purpose of this research is to investigate the impact of a foreign language on the causality bias (i.e., the illusion that two events are causally related when they are not). We predict that using a foreign language could reduce the illusions of causality. A total of 36 native English speakers participated in Experiment 1, 80 native Spanish speakers in Experiment 2. They performed a standard contingency learning task, which can be used to detect causal illusions. Participants who performed the task in their native tongue replicated the illusion of causality effect, whereas those performing the task in their foreign language were more accurate in detecting that the two events were causally unrelated...
February 1, 2018: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/29451088/a-marginalized-two-part-model-with-heterogeneous-variance-for-semicontinuous-data
#20
Valerie A Smith, John S Preisser
Semicontinuous data, characterized by a point mass at zero followed by a positive, continuous distribution, arise frequently in medical research. These data are typically analyzed using two-part mixtures that separately model the probability of incurring a positive outcome and the distribution of positive values among those who incur them. In such a conditional specification, however, standard two-part models do not provide a marginal interpretation of covariate effects on the overall population. We have previously proposed a marginalized two-part model that yields more interpretable effect estimates by parameterizing the model in terms of the marginal mean...
January 1, 2018: Statistical Methods in Medical Research
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