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https://www.readbyqxmd.com/read/28110507/computer-assisted-quantification-of-cd3-t-cells-in-follicular-lymphoma
#1
Fazly S Abas, Arwa Shana'ah, Beth Christian, Robert Hasserjian, Abner Louissaint, Michael Pennell, Berkman Sahiner, Weijie Chen, Muhammad Khalid Khan Niazi, Gerard Lozanski, Metin Gurcan
The advance of high resolution digital scans of pathology slides allowed development of computer based image analysis algorithms that may help pathologists in IHC stains quantification. While very promising, these methods require further refinement before they are implemented in routine clinical setting. Particularly critical is to evaluate algorithm performance in a setting similar to current clinical practice. In this article, we present a pilot study that evaluates the use of a computerized cell quantification method in the clinical estimation of CD3 positive (CD3+) T cells in follicular lymphoma (FL)...
January 22, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28110485/are-obese-patients-at-an-increased-risk-of-pelvic-floor-dysfunction-compared-to-non-obese-patients
#2
Isaac José Felippe Corrêa Neto, Rodrigo Ambar Pinto, José Marcio Neves Jorge, Marco Aurélio Santo, Leonardo Alfonso Bustamante-Lopez, Ivan Cecconello, Sérgio Carlos Nahas
PURPOSE: Factors associated with increased intra-abdominal pressure such as chronic cough, morbid obesity, and constipation may be related to pelvic floor dysfunction. In this study, we compared anorectal manometry values and clinical data of class II and III morbidly obese patients referred to bariatric surgery with that of non-obese patients. METHODS: We performed a case-matched study between obese patients referred to bariatric surgery and non-obese patients without anorectal complaints...
January 21, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28110480/casubtype-an-r-package-to-identify-gene-sets-predictive-of-cancer-subtypes-and-clinical-outcomes
#3
Hualei Kong, Pan Tong, Xiaodong Zhao, Jielin Sun, Hua Li
In the past decade, molecular classification of cancer has gained high popularity owing to its high predictive power on clinical outcomes as compared with traditional methods commonly used in clinical practice. In particular, using gene expression profiles, recent studies have successfully identified a number of gene sets for the delineation of cancer subtypes that are associated with distinct prognosis. However, identification of such gene sets remains a laborious task due to the lack of tools with flexibility, integration and ease of use...
January 21, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28110476/three-dimensional-texture-features-from-intensity-and-high-order-derivative-maps-for-the-discrimination-between-bladder-tumors-and-wall-tissues-via-mri
#4
Xiaopan Xu, Xi Zhang, Qiang Tian, Guopeng Zhang, Yang Liu, Guangbin Cui, Jiang Meng, Yuxia Wu, Tianshuai Liu, Zengyue Yang, Hongbing Lu
PURPOSE: This study aims to determine the three-dimensional (3D) texture features extracted from intensity and high-order derivative maps that could reflect textural differences between bladder tumors and wall tissues, and propose a noninvasive, image-based strategy for bladder tumor differentiation preoperatively. METHODS: A total of 62 cancerous and 62 wall volumes of interest (VOI) were extracted from T2-weighted MRI datasets of 62 patients with pathologically confirmed bladder cancer...
January 21, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28110475/pattern-recognition-of-spectral-entropy-features-for-detection-of-alcoholic-and-control-visual-erp-s-in-multichannel-eegs
#5
T K Padma Shri, N Sriraam
This paper presents a novel ranking method to select spectral entropy (SE) features that discriminate alcoholic and control visual event-related potentials (ERP'S) in gamma sub-band (30-55 Hz) derived from a 64-channel electroencephalogram (EEG) recording. The ranking is based on a t test statistic that rejects the null hypothesis that the group means of SE values in alcoholics and controls are identical. The SE features with high ranks are indicative of maximal separation between their group means. Various sizes of top ranked feature subsets are evaluated by applying principal component analysis (PCA) and k-nearest neighbor (k-NN) classification...
January 21, 2017: Brain Informatics
https://www.readbyqxmd.com/read/28110454/tackling-the-salinity-pollution-nexus-in-coastal-aquifers-from-arid-regions-using-nitrate-and-boron-isotopes
#6
V Re, E Sacchi
Salinization and nitrate pollution are generally ascertained as the main issues affecting coastal aquifers worldwide. In arid zones, where agricultural activities also result in soil salinization, both phenomena tend to co-exist and synergically contribute to alter groundwater quality, with severe negative impacts on human populations and natural ecosystems' wellbeing. It becomes therefore necessary to understand if and to what extent integrated hydrogeochemical tools can help in distinguishing among possible different salinization and nitrate contamination origins, in order to provide adequate science-based support to local development and environmental protection...
January 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28110451/the-importance-of-various-stages-of-succession-in-preservation-of-biodiversity-among-riparian-birds-in-northern-iran
#7
Zahra Sepehri Roshan, Sina Anushiravani, Soroor Karimi, Hossein Varasteh Moradi, Abdol Rasoul Salmanmahini
Every stage of succession may provide certain species with habitat requirements which are impossible in other stages of succession. This study attempts to evaluate the different stages of succession in terms of composition and structure of bird populations in Hyrcanian forests. Bird-habitat relationships were investigated by comparing vegetation characteristics in three successional stages including late, initial stage, and urban areas. Bird richness, diversity, and abundance were measured within a 25-m radius of each of the 120 sampling points in various stages of succession and urban areas from May to April (2014) in the Ziarat catchment...
February 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28110431/a-report-on-identification-of-sequence-polymorphism-in-barcode-region-of-six-commercially-important-cymbopogon-species
#8
Ashok Kumar Bishoyi, Aarti Kavane, Anjali Sharma, K A Geetha
CYMBOPOGON: is an important member of grass family Poaceae, cultivated for essential oils which have greater medicinal and industrial value. Taxonomic identification of Cymbopogon species is determined mainly by morphological markers, odour of essential oils and concentration of bioactive compounds present in the oil matrices which are highly influenced by environment. Authenticated molecular marker based taxonomical identification is also lacking in the genus; hence effort was made to evaluate potential DNA barcode loci in six commercially important Cymbopogon species for their individual discrimination and authentication at the species level...
January 21, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28110424/effects-of-caffeine-on-fractional-flow-reserve-values-measured-using-intravenous-adenosine-triphosphate
#9
Masafumi Nakayama, Taishiro Chikamori, Takashi Uchiyama, Yo Kimura, Nobuhiro Hijikata, Ryosuke Ito, Mikio Yuhara, Hideaki Sato, Yuichi Kobori, Akira Yamashina
We investigated the effects of caffeine intake on fractional flow reserve (FFR) values measured using intravenous adenosine triphosphate (ATP) before cardiac catheterization. Caffeine is a competitive antagonist for adenosine receptors; however, it is unclear whether this antagonism affects FFR values. Patients were evenly randomized into 2 groups preceding the FFR study. In the caffeine group (n = 15), participants were given coffee containing 222 mg of caffeine 2 h before the catheterization. In the non-caffeine group (n = 15), participants were instructed not to take any caffeine-containing drinks or foods for at least 12 h before the catheterization...
January 21, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28110405/cyanotoxins-producing-organisms-occurrence-toxicity-mechanism-of-action-and-human-health-toxicological-risk-evaluation
#10
REVIEW
Franca M Buratti, Maura Manganelli, Susanna Vichi, Mara Stefanelli, Simona Scardala, Emanuela Testai, Enzo Funari
Cyanobacteria were present on the earth 3.5 billion years ago; since then they have colonized almost all terrestrial and aquatic ecosystems. They produce a high number of bioactive molecules, among which some are cyanotoxins. Cyanobacterial growth at high densities, forming blooms, is increasing in extension and frequency, following anthropogenic activities and climate changes, giving rise to some concern for human health and animal life exposed to cyanotoxins. Numerous cases of lethal poisonings have been associated with cyanotoxins ingestion in wild animal and livestock...
January 21, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28110368/comparison-of-the-local-effects-of-a-600-%C3%AE-m-bare-fibre-at-high-laser-power-on-lung-parenchyma-nd-yag-laser-1320-vs-1064%C3%A2-nm
#11
Andreas Kirschbaum, Detlef K Bartsch, Peter Rexin
Lung metastases are often resected non-anatomically with a laser using a diode-pumped Nd:YAG laser at a wavelength of 1320 nm with a laser output of up to 60 W. Usually the removal of lesions is carried out in contact mode by means of a bare fibre. We compared the local effects of an Nd:YAG laser at a wavelength of 1064 nm with those at a wavelength of 1320 nm using a 600-μm bare fibre in contact mode in an experimental model. The investigations were carried out on porcine lungs freshly withdrawn at the abattoir...
January 21, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28110367/accurate-simultaneous-quantification-of-liver-steatosis-and-iron-overload-in-diffuse-liver-diseases-with-mri
#12
Manuela França, Ángel Alberich-Bayarri, Luis Martí-Bonmatí, Pedro Oliveira, Francisca Emanuel Costa, Graça Porto, José Ramón Vizcaíno, Javier Sanchez Gonzalez, Eduardo Ribeiro, João Oliveira, Helena Pessegueiro Miranda
PURPOSE: To evaluate the diagnostic performances of 3 Tesla multi-echo chemical shift-encoded gradient echo magnetic resonance (MECSE-MR) imaging to simultaneously quantify liver steatosis and iron overload in a wide spectrum of diffuse liver diseases having biopsy as reference standard. METHODS: MECSE-MR-acquired images were used to calculate fat fraction and iron content in a single breath-hold in 109 adult patients. Proton density fat fraction (PDFF) was prospectively estimated using complex-based data reconstruction with multipeak fat modeling...
January 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28110351/determining-lead-cadmium-and-mercury-in-cosmetics-using-sweeping-via-dynamic-chelation-by-capillary-electrophoresis
#13
Kuan-Ling Chen, Shiuh-Jen Jiang, Yen-Ling Chen
International limits have been established for metal impurities in cosmetics to prevent overexposure to heavy metal ions. Sweeping via dynamic chelation was developed using capillary electrophoresis to analyze lead (Pb), cadmium (Cd) and mercury (Hg) impurities in cosmetics. The sweeping via dynamic chelation mechanism involves a large volume of metal ions being swept by a small quantity of chelating agents that were electrokinetically injected into the capillary to chelate metal ions and increase the detection sensitivity...
January 21, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28110240/lead-exposure-is-related-to-hypercortisolemic-profiles-and-allostatic-load-in-brazilian-older-adults
#14
Juliana N Souza-Talarico, Deborah Suchecki, Robert-Paul Juster, Pierrich Plusquellec, Fernando Barbosa Junior, Vinícius Bunscheit, Tania Marcourakis, Tatiane Martins de Matos, Sonia J Lupien
Lead levels (Pb) have been linked to both hyper- and hypo-reactivity of hypothalamic-pituitary-adrenal axis (HPA) axis to acute stress in animals and humans. Similarly, allostatic load (AL), the 'wear and tear' of chronic stress, is associated with inadequate HPA axis activity. We examined whether Pb levels would be associated with altered diurnal cortisol profile, as a primary mediator of AL, during aging. Pb levels were measured from blood samples (BPb) of 126 Brazilian individuals (105 women), between 50 and 82 years old...
January 19, 2017: Environmental Research
https://www.readbyqxmd.com/read/28110139/boosting-current-generation-in-microbial-fuel-cells-by-an-order-of-magnitude-by-coating-an-ionic-liquid-polymer-on-carbon-anodes
#15
Lu Yang, Wenfang Deng, Youming Zhang, Yueming Tan, Ming Ma, Qingji Xie
Microbial fuel cells (MFCs) have attracted great attentions due to their great application potentials, but the relatively low power densities of MFCs still hinder their widespread practical applications. Herein, we report that the current generation in MFCs can be boosted by an order of magnitude, simply by coating a hydrophilic and positively charged ionic liquid polymer (ILP) on carbon cloth (CC) or carbon felt (CF). The ILP coating not only can increase the bacterial loading capacity due to the electrostatic interactions between ILP and bacterial cells, but also can improve the mediated extracellular electron transfer between the electrode and the cytochrome proteins on the outer membrane of Shewanella putrefaciens cells...
January 14, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28110123/investigation-of-123-i-production-using-electron-accelerator
#16
Albert Avetisyan, Robert Avagyan, Ruben Dallakyan, Gohar Avdalyan, Nikolay Dobrovolsky, Vasak Gavalyan, Ivetta Kerobyan, Gevorg Harutyunyan
The possibility of (123)I isotope production with the help of the high-intensity bremsstrahlung photons produced by the electron beam of the LUE50 linear electron accelerator at the A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute [YerPhI]) is considered. The production method has been established and shown to be successful. The (124)Xe(γ,n)(123)Xe→(123)I nuclear reaction has been investigated and the cross-section was calculated by nuclear codes TALYS 1.6 and EMPIRE 3.2. The optimum parameter of the thickness of the target was determined by GEANT4 code...
December 22, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28110070/mesoscale-porosity-at-the-dentin-enamel-junction-could-affect-the-biomechanical-properties-of-teeth
#17
Elsa Vennat, Wenlong Wang, Rachel Genthial, Bertrand David, Elisabeth Dursun, Aurélien Gourrier
: In this paper, the 3D-morphology of the porosity in dentin is investigated within the first 350 μm from the dentin-enamel junction (DEJ) by fluorescence confocal laser scanning microscopy (CLSM). We found that the porous microstructure exhibits a much more complex geometry than classically described, which may impact our fundamental understanding of the mechanical behavior of teeth and could have practical consequences for dental surgery. Our 3D observations reveal numerous fine branches stemming from the tubules which may play a role in cellular communication or mechanosensing during the early stages of dentinogenesis...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28110009/influence-of-ph-on-heavy-metal-speciation-and-removal-from-wastewater-using-micellar-enhanced-ultrafiltration
#18
Jinhui Huang, Fang Yuan, Guangming Zeng, Xue Li, Yanling Gu, Lixiu Shi, Wenchu Liu, Yahui Shi
pH plays an important role in heavy metal removal during micellar-enhanced ultrafiltration (MEUF). In the present work, the influence of pH on heavy metal speciation and removal from wastewater by MEUF was investigated using an anionic surfactant (sodium dodecyl sulfate, SDS) and a hydrophilic membrane (polyether sulfone). Experiments were performed with pH values in the range of 1-12. Metal ion removal efficiency (R) was used to assess the effects of the MEUF process. Results showed that better removal rate of copper and cadmium was achieved at high pH values (pH > 3) with SDS feed concentration of 8 mM, while the optimal pH range was 3-10 for zinc and lead...
December 28, 2016: Chemosphere
https://www.readbyqxmd.com/read/28110005/concentrations-sources-and-human-health-risk-of-inhalation-exposure-to-air-toxics-in-edmonton-canada
#19
Md Aynul Bari, Warren B Kindzierski
With concern about levels of air pollutants in recent years in the Capital Region of Alberta, an investigation of ambient concentrations, sources and potential human health risk of hazardous air pollutants (HAPs) or air toxics was undertaken in the City of Edmonton over a 5-year period (2009-2013). Mean concentrations of individual HAPs in ambient air including volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs) and trace metals ranged from 0.04 to 1.73 μg/m(3), 0.01-0.54 ng/m(3), and 0...
January 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/28109965/a-novel-acidic-ph-fluorescent-probe-based-on-a-benzothiazole-derivative
#20
Qiujuan Ma, Xian Li, Suxiang Feng, Beibei Liang, Tiqiang Zhou, Min Xu, Zhuoyi Ma
A novel acidic pH fluorescent probe 1 based on a benzothiazole derivative has been designed, synthesized and developed. The linear response range covers the acidic pH range from 3.44 to 6.46, which is valuable for pH researches in acidic environment. The evaluated pKa value of the probe 1 is 4.23. The fluorescence enhancement of the studied probe 1 with an increase in hydrogen ions concentration is based on the hindering of enhanced photo-induced electron transfer (PET) process. Moreover, the pH sensor possesses a highly selective response to H(+) in the presence of metal ions, anions and other bioactive small molecules which would be interfere with its fluorescent pH response...
January 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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