Pedro Barata, Shuchi Gulati, Andrew Elliott, Hans J Hammers, Earle F Burgess, Benjamin A Gartrell, Sourat Darabi, Mehmet A Bilen, Arnab Basu, Daniel M Geynisman, Nancy A Dawson, Matthew R Zibelman, Tian Zhang, Shuanzeng Wei, Charles J Ryan, Elisabeth I Heath, Kelsey A Poorman, Chadi Nabhan, Rana R McKay
Molecular profiling of clear cell RCC (ccRCC) tumors of clinical trial patients has identified distinct transcriptomic signatures with predictive value, yet data in non-clear cell variants (nccRCC) are lacking. We examined the transcriptional profiles of RCC tumors representing key molecular pathways, from a multi-institutional, real-world patient cohort, including ccRCC (n = 508) and centrally-reviewed nccRCC (n = 149) samples. ccRCC had increased angiogenesis signature scores compared to the heterogeneous group of nccRCC tumors (mean z-score 0...
April 23, 2024: Journal of Clinical Investigation