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Spirometry in TB

R K Osman, K Mortimer, G Bjune, A I El Sony
Background: Chronic respiratory disease (CRD) causes substantial morbidity and mortality. Although the global CRD epidemic collides with the tuberculosis (TB) epidemic in many low- and middle-income country settings, the risk of TB-associated CRD is not well described in countries with a high burden of TB. Methods: We recruited 136 patients with a history of sputum smear-positive pulmonary TB (PTB) from the TB clinic at Omdurman Teaching Hospital in Khartoum, Sudan, and 136 age- and sex-matched community controls, between 28 July 2013 and 30 December 2013...
September 2016: Public Health Action
Jamilah Meghji, Hope Simpson, S Bertel Squire, Kevin Mortimer
BACKGROUND: Tuberculosis is an important risk factor for chronic respiratory disease in resource poor settings. The persistence of abnormal spirometry and symptoms after treatment are well described, but the structural abnormalities underlying these changes remain poorly defined, limiting our ability to phenotype post-TB lung disease in to meaningful categories for clinical management, prognostication, and ongoing research. The relationship between post-TB lung damage and patient-centred outcomes including functional impairment, respiratory symptoms, and health related quality of life also remains unclear...
2016: PloS One
Katerina Dimakou, Christina Triantafillidou, Michail Toumbis, Kyriaki Tsikritsaki, Katerina Malagari, Petros Bakakos
BACKGROUND AND OBJECTIVES: Non-Cystic Fibrosis (CF) bronchiectasis is common in Greece but little attention has been paid to the investigation of its aetiology, clinical, radiological, microbiological and lung function profile. METHODS: We prospectively evaluated patients with non-CF bronchiectasis confirmed by high resolution computed tomography (HRCT) of the chest. Aetiology, clinical data, radiology score, microbiological profile and lung function were investigated...
July 2016: Respiratory Medicine
Matt Boyd, Tony Blakely, June Atkinson
AIM: To investigate the effects on lung function of IV magnesium in acute exacerbations of COPD (AECOPD), when given in conjunction with standard bronchodilator therapy. METHODS: This was a pilot study to a randomised, double-blinded, placebo-controlled trial. 30 patients presenting to ED with AECOPD were included. In addition to standard bronchodilator therapy, 17 patients were given saline, and 13 received 2 g of magnesium sulphate intravenously. Spirometry was carried out at presentation (TA), after initial standard bronchodilator therapy (TB) and immediately (T0), at 60 minutes (T60) and 120 minutes (T120) after trial drug infusion...
January 29, 2016: New Zealand Medical Journal
Cassiopia Cary, Manjit Jhajj, John Cinicola, Richard Evans, Pramil Cheriyath, Venaka S Gorepatti
Endobronchial tuberculosis (EBTB) is a sequelae of pulmonary tuberculosis (TB) that extends to the endobronchial or endotracheal wall causing inflammation, edema, ulceration, granulation or fibrosis of mucosa and submucosa. This case depicts a 20 year old foreign-born woman with a history of active pulmonary TB on anti-TB chemotherapy, who presented with worsening stridor, dyspnea, cough and weight loss. The disease state was diagnosed with multiple modalities including, spirometry, CT scan of the neck, and bronchoscopy...
December 2015: Annals of Medicine and Surgery
Daniel O Obaseki, Gregory E Erhabor, Louisa Gnatiuc, Olufemi O Adewole, Sonia A Buist, Peter G Burney
Global estimates suggest that Chronic Obstructive Pulmonary Disease (COPD) is emerging as a leading cause of death in developing countries but there are few spirometry-based general population data on its prevalence and risk factors in sub-Saharan Africa. We used the Burden of Obstructive Lung Disease (BOLD) protocol to select a representative sample of adults aged 40 years and above in Ile-Ife, Nigeria. All the participants underwent spirometry and provided information on smoking history, biomass and occupational exposures as well as diagnosed respiratory diseases and symptoms...
2016: COPD
J-P Myong, H-K Yoon, C K Rhee, H-R Kim, J-W Koo
SETTING: Nationwide general population in South Korea. OBJECTIVE: Except for tobacco smoking, risk factors for the impairment of lung function have not been widely evaluated. We evaluated the risk factors for lung function impairment among the general non-smoking Korean population. DESIGN: A total of 8164 non-smokers from the spirometry data set of the Korean National Health and Nutrition Examination Surveys IV and V (2008-2010) were included in the study...
September 2015: International Journal of Tuberculosis and Lung Disease
Simone de Sousa Elias Nihues, Eliane Viana Mancuzo, Nara Sulmonetti, Flávia Patussi Correia Sacchi, Vanessa de Souza Viana, Eduardo Martins Netto, Silvana Spindola Miranda, Julio Croda
BACKGROUND: Questionnaire and spirometry were applied to post-tuberculosis indigenous and non-indigenous individuals from Dourados, Brazil, to investigate the prevalence of chronic respiratory symptoms and pulmonary dysfunction. METHODS: This was a cross-sectional study in cured tuberculosis individuals as reported in the National System on Reportable Diseases (SINAN) from 2002 to 2012. RESULTS: One hundred and twenty individuals were included in the study and the prevalence of chronic respiratory symptoms was 45% (95% CI, 34-59%)...
September 2015: Brazilian Journal of Infectious Diseases
Maxwell O Akanbi, Babafemi O Taiwo, Chad J Achenbach, Obianuju B Ozoh, Daniel O Obaseki, Halima Sule, Oche O Agbaji, Christiana O Ukoli
OBJECTIVE: To determine the prevalence and risk factors for chronic obstructive pulmonary disease (COPD) among HIV-infected adults in Nigeria. DESIGN: Cross-sectional study. METHODS: HIV-infected adults aged ≥ 30 years with no acute ailments accessing care at the antiretroviral therapy clinic of Jos University Teaching Hospital were enrolled consecutively. Participants were interviewed to obtain pertinent demographic and clinical information, including exposure to risk factors for COPD...
May 2015: Journal of AIDS & Clinical Research
Aliasghar Farazi, Mansooreh Jabbariasl
INTRODUCTION: Co-existence of silicosis and tuberculosis is known as silico-tuberculosis. This article review the frequency of silicosis and tuberculosis in workers who exposed to silica and evaluate influencing factors that may increase the risk of silico-tuberculosis. METHODS: An analytical cross-sectional study was performed in silica exposed workers in central province of Iran during 2011-2012. Sampling method was un-randomized and considering all workers who at least 6 months exposed to silica...
2015: Pan African Medical Journal
André F S Amaral, Sonia Coton, Bernet Kato, Wan C Tan, Michael Studnicka, Christer Janson, Thorarinn Gislason, David Mannino, Eric D Bateman, Sonia Buist, Peter G J Burney
In small studies and cases series, a history of tuberculosis has been associated with both airflow obstruction, which is characteristic of chronic obstructive pulmonary disease, and restrictive patterns on spirometry. The objective of the present study was to assess the association between a history of tuberculosis and airflow obstruction and spirometric abnormalities in adults.The study was performed in adults, aged 40 years and above, who took part in the multicentre, cross-sectional, general population-based Burden of Obstructive Lung Disease study, and had provided acceptable post-bronchodilator spirometry measurements and information on a history of tuberculosis...
October 2015: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Jung Yeon Lee, Yong Il Hwang, Yong Bum Park, Jae Yong Park, Ki Uk Kim, Yeon-Mok Oh, Hyoung Kyu Yoon, Ho Il Yoon, Sueng Su Sheen, Sang Yeub Lee, Chang-Hoon Lee, Heung Bum Lee, Sung Chul Lim, Sung Soo Jung, Kyungwon Oh, Yuna Kim, Chaemin Chun, Kwang Ha Yoo
The aim of the study was to evaluate the prevalence of restrictive ventilatory defect and to determine the risk factors in subjects with spirometrically-defined restrictive ventilatory defect. We used the population-based, fourth-2, 3 (2008, 2009) and fifth (2010-2012) Korea National Health and Nutrition Examination Survey (KNHANES) to analyze 15,073 subjects, aged ≥40 yr who underwent spirometry. Chest radiographs were also analyzed to identify restrictive lung disease. Spirometrically-defined restrictive ventilatory defect (FEV1/FVC≥70% and FVC<80% of mean predicted value) was detected in 11...
June 2015: Journal of Korean Medical Science
Hyun Jung Kim, Seunghee Baek, Hee Jin Kim, Jae Seung Lee, Yeon-Mok Oh, Sang-Do Lee, Sei Won Lee
BACKGROUND: Although smoking is the most important and modifiable cause of chronic obstructive pulmonary disease (COPD), other risk factors including asthma and tuberculosis (TB) are also associated. It is common for COPD patients to have more than one of these risk factors. The aims of this study were to determine the prevalence of airflow limitation (FEV1/FVC<0.7) according to the risk factors and to investigate their impact and interaction in airflow limitation. METHODS: From the Korean National Health and Nutrition Examination Survey between 2008 and 2012, we analyzed participants over 40 years of age by spirometry, chest radiograph and questionnaire about asthma and smoking history...
2015: PloS One
Devan Jaganath, J Jaime Miranda, Robert H Gilman, Robert A Wise, Gregory B Diette, Catherine H Miele, Antonio Bernabe-Ortiz, William Checkley
BACKGROUND: It is unclear how geographic and social diversity affects the prevalence of chronic obstructive pulmonary disease (COPD). We sought to characterize the prevalence of COPD and identify risk factors across four settings in Peru with varying degrees of urbanization, altitude, and biomass fuel use. METHODS: We collected sociodemographics, clinical history, and post-bronchodilator spirometry in a randomly selected, age-, sex- and site-stratified, population-based sample of 2,957 adults aged ≥35 years (median age was 54...
2015: Respiratory Research
Donna de Grass, Shamila Manie, Seyi Ladele Amosun
BACKGROUND: Patients with Pulmonary Tuberculosis (PTB) often develop impairment in pulmonary function due to anatomical changes secondary to the illness. Physiotherapy in the form of pulmonary rehabilitation has been advocated. OBJECTIVE: The aim of the study was to determine whether adherence to a six-week home-based pulmonary rehabilitation programme (PRP) improved the baseline measurements of lung function, exercise tolerance and health-related quality of life (HRQoL) in patients receiving out-patient treatment for PTB...
December 2014: African Health Sciences
David K Lagat, Allison K DeLong, Gregory A Wellenius, E Jane Carter, Gerald S Bloomfield, Eric J Velazquez, Joseph Hogan, Sylvester Kimaiyo, Charles B Sherman
BACKGROUND: Small observational studies have found that isolated right heart failure (IRHF) is prevalent among women of sub-Saharan Africa. Further, several risk factors for the development of IRHF have been identified. However, no similar studies have been conducted in Kenya. OBJECTIVE: We hypothesized that specific environmental exposures and comorbidities were associated with IRHF in women of western Kenya. METHODS: We conducted a case-control study at a referral hospital in western Kenya...
June 2014: Global Heart
Yong Suk Jo, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Sang-Min Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Chang-Hoon Lee
BACKGROUND: Multiple comorbidities related to chronic obstructive pulmonary disease (COPD) make it a difficult disease to treat. The relationship between these comorbidities and COPD has not been fully investigated. We aimed to determine whether COPD was independently associated with various comorbidities. METHODS: This was a cross-sectional study, which used data from the Korean National Health and Nutrition Examination Survey (KNHANES) V conducted between 2010 and 2012...
January 2015: Respiratory Medicine
Agnaldo José Lopes, Gustavo Bittencourt Camilo, Sara Lucia Silveira de Menezes, Fernando Silva Guimarães
BACKGROUND: Bronchiectasis develops along the natural course of several respiratory and systemic conditions and induces significant changes in the morphofunctional structure of airways. Our objective was to assess the impact of various causes of bronchiectasis on clinical data, pulmonary function tests, and high-resolution computed tomography (HRCT). METHODS: The present report was a cross-sectional study that was conducted with 112 consecutive patients with bronchiectasis, who were allocated to five groups, as follows: sequelae of tuberculosis, history of non-tuberculosis infection, cystic fibrosis (CF), primary ciliary dyskinesia (PCD), and rheumatoid arthritis...
March 2015: Clinical Medicine & Research
Sayyed Gholamreza Mortazavi-Moghaddam, Sayyed Alireza Saadatjoo
BACKGROUND: There are many reports on the association between anthracosis and tuberculosis. This study focuses on bronchial anthracosis and associated diseases in the province of South Khorasan-Iran. METHODS: This case-series study is performed on patients referred to the Vali-e-Asre Hospital (South Khorasan-Iran) for bronchoscopic evaluations during the period of 2009-2012. Written informed consents were obtained prior to bronchoscopic evaluations. The criterion for diagnosis of bronchial anthracosis was black pigmentation on direct observation of bronchus...
September 2014: Iranian Journal of Medical Sciences
Woong Jun Kim, June Seok Song, Dong Won Park, Hyun Jung Kwak, Ji-Yong Moon, Sang-Heon Kim, Jang Won Sohn, Ho Joo Yoon, Dong Ho Shin, Sung Soo Park, Tae-Hyung Kim
BACKGROUND/AIMS: Smoking is widely acknowledged as the single most important risk factor for chronic obstructive pulmonary disease (COPD). However, the risk of COPD in nonsmokers exposed to secondhand smoke remains controversial. In this study, we investigated the association of secondhand smoke exposure with COPD prevalence in nonsmokers who reported never smoking. METHODS: This study was based on data obtained from the Korean National Health and Nutrition Examination Surveys (KNHANES) conducted from 2008 to 2010...
September 2014: Korean Journal of Internal Medicine
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