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https://www.readbyqxmd.com/read/29125642/genistein-ameliorates-fat-accumulation-through-ampk-activation-in-fatty-acid-induced-brl-cells
#1
Huijia Zhong, Huanhuan Liu, Zhuoqin Jiang
Genstein is the most abundant phytoestrogen in soybean that was reported to play positive roles in menopausal syndrome and metabolic syndrome. In the present study, we investigated the effects and potential mechanisms of genistein against progression of nonalcoholic fatty liver disease (NAFLD) in BRL cells treated with fatty acid mixture (oleate/palmitate, 2:1 ratio). Our data demonstrated that genistein remarkably improved fatty acid mixture-induced hepatocelluler fat accumulation, inhibited upregulation of genes expression related to fatty acid synthesis, and derepressed those associated with fatty acid oxidation...
November 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29122235/-acute-stress-and-broken-heart-syndrome-a-case-report
#2
Juliana Vergel, Sebastián Tamayo-Orozco, Andrés Felipe Vallejo-Gómez, María Teresa Posada, Diana Restrepo
INTRODUCTION: Stress has been associated with an acute heart failure syndrome of important morbidity and mortality. METHODS: Case report and non-systematic review of the relevant literature. CASE PRESENTATION: A 65-year-old woman with a history of an untreated generalized anxiety disorder, whom after the violent death of her son presented with oppressive chest pain irradiated to neck and left superior extremity, lasting for more than 30minutes, initial clinical suspect suggests acute coronary syndrome...
October 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29111858/women-s-health-endocrine-update
#3
Ekta Kapoor, Stephanie Faubion, Stephanie Hines, Cynthia A Stuenkel
The clinical update serves as a brief review of recently published, high-impact, and potentially practice changing journal articles summarized for our readers. Topics include menopause, sexual dysfunction, breast health, contraception, osteoporosis, and cardiovascular disease. In this clinical update, we selected four recent high-impact publications related to endocrine issues in women. We have chosen to highlight research on subclinical hypothyroidism during pregnancy and adverse pregnancy outcomes, including cognitive outcomes in offspring; the progression of metabolic syndrome severity during the menopausal transition; and the association of diabetes and metformin use with cancer risk and mortality...
November 7, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29106307/menopause-lung-function-and-obstructive-lung-disease-outcomes-a-systematic-review
#4
B Campbell, S R Davis, M J Abramson, G Mishra, D J Handelsman, J L Perret, S C Dharmage
BACKGROUND: The menopausal transition may have significant consequences for respiratory health, risk of chronic respiratory disease and management strategies. OBJECTIVE: To systematically summarize the literature regarding the impact of menopause status on respiratory health outcomes. METHODS: PubMed was searched systematically to identify population-based studies investigating the associations between menopause status and respiratory outcomes including asthma, chronic obstructive pulmonary disease (COPD), respiratory symptoms and lung function...
November 6, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29106305/prediction-of-age-at-menopause-in-women-with-polycystic-ovary-syndrome
#5
S Minooee, F Ramezani Tehrani, M Rahmati, M Ali Mansournia, F Azizi
OBJECTIVE: Considering the role of anti-Müllerian hormone (AMH) in female fertility and its high levels in women with polycystic ovary syndrome (PCOS), the longer reproductive span of these women is in doubt. In the present study, we aimed to improve earlier predictions using a non-linear model to substantiate the question as to whether PCOS women reach menopause later. METHODS: In total, 1162 women aged 20-50 years, comprising 378 PCOS cases and 784 eumenorrheic non-hirsute women, met the eligibility criteria...
November 6, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29104286/leptin-regulation-of-the-p53-hif1%C3%AE-pkm2-aromatase-axis-in-breast-adipose-stromal-cells-a-novel-mechanism-for-the-obesity-breast-cancer-link
#6
H Zahid, K Subbaramaiah, N M Iyengar, X K Zhou, I-C Chen, P Bhardwaj, A Gucalp, M Morrow, C A Hudis, A J Dannenberg, K A Brown
BACKGROUND/OBJECTIVES: Obesity (body mass index (BMI) ⩾30) is associated with an increased risk of estrogen-dependent breast cancer after menopause. Levels of aromatase, the rate-limiting enzyme in estrogen biosynthesis, are elevated in breast tissue of obese women. Recently, the regulation of aromatase by the p53-HIF1α/PKM2 axis was characterized in adipose stromal cells (ASCs) of women with Li-Fraumeni Syndrome, a hereditary cancer syndrome that predisposes to estrogen-dependent breast cancer...
November 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29100781/estrogens-and-female-liver-health
#7
Karen L Chen, Zeynep Madak-Erdogan
Due to declining estrogen levels during menopause, NAFLD prevalence is higher in postmenopausal women compared to in premenopausal women or in men. Postmenopausal women are more susceptible to weight gain, fat redistribution and dyslipidemia, all major hallmarks of metabolic syndrome associated with increased NAFLD risk. Gut microbiota plays important roles in development of gastrointestinal tract, metabolism and immunity. Host-microbe interactions allows regulation of a wide range of pathways that affect healthy and diseased physiology...
November 1, 2017: Steroids
https://www.readbyqxmd.com/read/29095010/-metabolic-syndrome-and-visceral-fat-in-women-with-cardiovascular-risk-factor
#8
Anxela Soto Rodríguez, José Luis García Soidán, Mª Jesús Arias Gómez, Raquel Leirós Rodríguez, Alberto Del Álamo Alonso, Mª Reyes Pérez Fernández
INTRODUCTION: Cardiovascular diseases are the leading cause of death in women after menopause, since after this stage there are profound metabolic and hormonal changes which favor the development of metabolic syndrome. An increase in the percentage of visceral fat may be related to the onset of this syndrome. OBJECTIVE: To establish the relationship between visceral fat and parameters of the metabolic syndrome and to determine the optimal cut-off point for the variables related to obesity in women with a cardiovascular risk factor...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29081904/takotsubo-cardiomyopathy-pathophysiology-and-role-of-cardiac-biomarkers-in-differential-diagnosis
#9
REVIEW
Prabhakaran Gopalakrishnan, Ramsha Zaidi, Muhammad Rizwan Sardar
Takotsubo cardiomyopathy (TC) is characterized by reversible ventricular dysfunction, not limited to the distribution of an epicardial coronary artery. A disease primarily afflicting post-menopausal women, it is frequently mistaken for acute anterior wall myocardial infarction. Alternatively called Stress Cardiomyopathy, physical or emotional triggers are identified in only three fourths of TC patients. Long considered a benign condition, recent findings suggest poor short term prognosis similar to acute coronary syndrome (ACS)...
September 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/29080671/sex-differences-and-estradiol-involvement-in-hyperalgesia-and-allodynia-in-an-experimental-model-of-fibromyalgia
#10
Alberto Hernandez-Leon, Yarim Elideth De la Luz-Cuellar, Vinicio Granados-Soto, María Eva González-Trujano, Alonso Fernández-Guasti
Fibromyalgia (FM) is a musculoskeletal chronic pain syndrome. Its prevalence in women is higher than in men possibly by hormonal factors given that symptoms are aggravated during sex hormone-related events, such as the premenstrual period, pregnancy, postpartum or menopause. The aim of the present study was to investigate whether hyperalgesia and allodynia, in reserpine-induced experimental FM, depend on sex, estrous cycle, ovariectomy and replacement with 17β-estradiol. To fulfill this objective, we compared males, intact females with known estrous cycle phases and ovariectomized (OVX) rats treated with 17β-estradiol...
November 8, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29071830/-hormonal-treatments-and-venous-thrombosis-in-women
#11
Justine Hugon-Rodin, Marc Blondon, Julie Bénard, Geneviève Plu-Bureau, Isabelle Streuli
Venous thromboembolism is frequently associated with hormonal factors in women. A thorough medical history taking of vascular risks and an individual evaluation of the risk-benefit ratio should precede any prescription of hormonal therapies. In contrary to progestin-only-pills, estroprogestative contraceptives increase 3-6 times the risk of venous thrombosis. In assisted reproductive techniques, venous thrombosis is frequently associated with the occurrence of a severe ovarian hyperstimulation syndrome. Antagonist ovarian stimulation protocols lower the risk of hyperstimulation and should therefore be preferred...
October 25, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29064335/overall-safety-of-ospemifene-in-postmenopausal-women-from-placebo-controlled-phase-2-and-3-trials
#12
James A Simon, Corrado Altomare, Susannah Cort, Wei Jiang, JoAnn V Pinkerton
OBJECTIVE: To evaluate the safety of daily oral ospemifene 60 mg, estrogen agonist/antagonist, used to treat moderate-to-severe dyspareunia due to postmenopausal vulvovaginal atrophy, which is part of genitourinary syndrome of menopause. METHODS: Post hoc analysis of safety data (treatment-emergent adverse events [TEAEs]) pooled from six phase 2 and 3 randomized, double-blind, multicenter placebo-controlled studies, evaluating the effects of ospemifene 60 mg on the breast, cardiovascular system, and bone in postmenopausal women...
October 24, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29064321/metabolic-syndrome-in-menopause-and-associated-factors-a-meta-analysis
#13
D Pu, R Tan, Q Yu, J Wu
OBJECTIVE: Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular disease and diabetes. Menopause is associated with an increased risk for MetS. The purpose of this meta-analysis is to better understand the relationship between MetS and menopause. METHODS: MEDLINE and EMBASE were searched for all the associated articles on (1) MetS components in postmenopausal women vs. premenopausal women, (2) comparison of MetS incidence between surgical menopause and natural menopause, (3) the effect of hormone therapy (HT) with 17β-estradiol (E2) compared to conjugated equine estrogen (CEE) on MetS components among postmenopausal women...
October 24, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29054504/proteomics-in-plasma-of-ovariectomized-rats-and-those-exposed-to-estradiol-valerate
#14
Hai Jiang, Wenpei Bai, Wenjuan Wang, Ke Wang, Jing Jia, Jing Zhang, He Diao, Lihua Qin
The menopausal period, an inevitable physiological process for women, is frequently associated with physiological and psychological dysfunction attributable to substantial fluctuation and gradual decrease in female hormones induced by ovarian failure, leading to corresponding symptoms and diseases that impact multiple systems in the body to varying degrees. As prior studies have focused primarily on menopausal syndrome-related pathophysiological changes and hormone replacement therapy effects, here we approached menopausal disease incidence risk and pathogenesis through systemic plasma proteomics analysis...
October 17, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29051304/consequences-of-advanced-aging-on-renal-function-in-chronic-hyperandrogenemic-female-rat-model-implications-for-aging-women-with-polycystic-ovary-syndrome
#15
Chetan N Patil, Lorraine C Racusen, Jane F Reckelhoff
Polycystic ovary syndrome (PCOS) is the most common endocrine and reproductive disorder in premenopausal women, characterized by hyperandrogenemia, metabolic syndrome, and inflammation. Women who had PCOS during their reproductive years remain hyperandrogenemic after menopause. The consequence of chronic hyperandrogenemia with advanced aging has not been studied to our knowledge. We have characterized a model of hyperandrogenemia in female rats and have aged them to 22-25 months to mimic advanced aging in hyperandrogenemic women, and tested the hypothesis that chronic exposure to hyperandrogenemia with aging has a deleterious effect on renal function...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29040373/nonsurgical-vulvovaginal-rejuvenation-with-radiofrequency-and-laser-devices-a-literature-review-and-comprehensive-update-for-aesthetic-surgeons
#16
Ali A Qureshi, Marissa M Tenenbaum, Terence M Myckatyn
Nonsurgical vulvovaginal rejuvenation (NVR) is growing in popularity as a treatment for restoration of youthful female genitalia. Numerous radiofrequency (RF) and laser devices have entered the market claiming improvement in vaginal laxity and genitourinary syndrome of menopause. There is a paucity of evidence existing concerning the effectiveness of these devices for both pre- and postmenopausal women with laxity and/or atrophy at the histologic and clinical level. Therefore, the goal of this review is to scrutinize the peer-reviewed data on NVR with RF and laser devices, identify gaps in existing literature, and propose opportunities for further investigation...
September 20, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29040220/vaginal-estrogen-in-the-treatment-of-genitourinary-syndrome-of-menopause-and-risk-of-endometrial-cancer-an-assessment-of-recent-studies-provides-reassurance
#17
JoAnn V Pinkerton, Andrew M Kaunitz, JoAnn E Manson
No abstract text is available yet for this article.
October 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29040217/shining-the-light-on-genitourinary-syndrome-of-menopause-in-survivors-of-breast-cancer
#18
Sheryl Kingsberg, Lisa Larkin
No abstract text is available yet for this article.
October 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29033611/stable-ischemic-heart-disease-in-women-current-perspectives
#19
REVIEW
Fatima Samad, Anushree Agarwal, Zainab Samad
Cardiovascular disease is the leading cause of death in women accounting for 1 in every 4 female deaths. Pathophysiology of ischemic heart disease in women includes epicardial coronary artery, endothelial dysfunction, coronary vasospasm, plaque erosion and spontaneous coronary artery dissection. Angina is the most common presentation of stable ischemic heart disease (SIHD) in women. Risk factors for SIHD include traditional risks such as older age, obesity (body mass index [BMI] >25 kg/m(2)), smoking, hypertension, dyslipidemia, cerebrovascular and peripheral vascular disease, sedentary lifestyle, family history of premature coronary artery disease, metabolic syndrome and diabetes mellitus, and nontraditional risk factors, such as gestational diabetes, insulin resistance/polycystic ovarian disease, pregnancy-induced hypertension, pre-eclampsia, eclampsia, menopause, mental stress and autoimmune diseases...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29031895/chronic-pelvic-pain-in-an-interdisciplinary-setting-1-year-prospective%C3%A2-cohort
#20
Catherine Allaire, Christina Williams, Sonja Bodmer-Roy, Sean Zhu, Kristina Arion, Kristin Ambacher, Jessica Wu, Ali Yosef, Fontayne Wong, Heather Noga, Susannah Britnell, Holly Yager, Mohamed A Bedaiwy, Arianne Y Albert, Sarka Lisonkova, Paul J Yong
BACKGROUND: Chronic pelvic pain affects ∼15% of women, and presents a challenging problem for gynecologists due to its complex etiology involving multiple comorbidities. Thus, an interdisciplinary approach has been proposed for chronic pelvic pain, where these multifactorial comorbidities can be addressed by different interventions at a single integrated center. Moreover, while cross-sectional studies can provide some insight into the association between these comorbidities and chronic pelvic pain severity, prospective longitudinal cohorts can identify comorbidities associated with changes in chronic pelvic pain severity over time...
October 12, 2017: American Journal of Obstetrics and Gynecology
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