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https://www.readbyqxmd.com/read/28912780/inflammatory-markers-for-arterial-stiffness-in-cardiovascular-diseases
#1
REVIEW
Ioana Mozos, Clemens Malainer, Jarosław Horbańczuk, Cristina Gug, Dana Stoian, Constantin Tudor Luca, Atanas G Atanasov
Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matrix degradation, oxidative stress, elastolysis, and degradation of collagen. The present paper reviews main mechanisms explaining the crosstalk between inflammation and arterial stiffness and the most common inflammatory markers associated with increased arterial stiffness, considering the most recent clinical and experimental studies...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28881431/fractional-co2-laser-of-the-vagina-for-genitourinary-syndrome-of-menopause-is-the-out-of-pocket-cost-worth-the-outcome-of-treatment
#2
Patrick Lang, Jeffrey R Dell, Leonard Rosen, Peter Weiss, Mickey Karram
OBJECTIVES: The purpose of this study is to assess patient's satisfaction treatment outcomes and out-of-pocket expense for the fractional CO2 laser (SmartXide) in the treatment of genitourinary symptoms of menopause (GSM). MATERIALS AND METHODS: A multicenter retrospective cohort study of patients who completed a course of three vaginal treatments with the SmartXide(11) Fractional CO2 laser. Patients contacted via telephone and asked to participate in questionnaires to evaluate for adverse outcomes since last treatment, symptom severity before and after treatment, patient satisfaction with treatment, patient satisfaction with out-of-pocket expense, and sexual function...
September 7, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28845761/lipid-nanoparticles-for-nasal-intranasal-drug-delivery
#3
S Cunha, M H Amaral, J M Sousa Lobo, Ana C Silva
Studies on the development of drug delivery systems have increased because these systems have particular characteristics that allow them to improve therapeutics. Among these, lipid nanoparticles (solid lipid nanoparticles, SLNs; and nanostructured lipid carriers, NLCs) have demonstrated suitability for drug targeting. The nasal administration of drug-loaded lipid nanoparticles showed effectiveness in treating central nervous system (CNS) disorders, particularly neurodegenerative diseases, because the nasal route (also called intranasal route) allows direct nose-to-brain drug delivery by means of lipid nanoparticles...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/28843942/sexual-function-in-women-suffering-from-genitourinary-syndrome-of-menopause-treated-with-fractionated-co2-laser
#4
REVIEW
Stefano Salvatore, Eleni Pitsouni, Fabio Del Deo, Marta Parma, Stavros Athanasiou, Massimo Candiani
INTRODUCTION: Genitourinary syndrome of menopause (GSM) has a significant impact on the trophism of the genital and lower urinary tracts and can considerably impair sexual function. Fractional CO2 laser has a regenerative effect on vulvovaginal tissue trophism after menopause. AIM: To review the available literature on the effect of fractional CO2 laser on the sexual function of postmenopausal women affected by GSM. METHODS: A database search was carried out using the terms CO2laser, vaginal atrophy, sexual function, dyspareunia, and genitourinary syndrome of menopause and excluding studies using other types of laser or including breast cancer survivors with vulvovaginal atrophy...
August 23, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28843780/epidemiology-of-estrogen-and-dementia-in-women-with-down-syndrome
#5
REVIEW
Nicole Schupf, Joseph H Lee, Deborah Pang, Warren B Zigman, Benjamin Tycko, Sharon Krinsky-McHale, Wayne Silverman
Several lines of investigation have shown a protective role for estrogen in Alzheimer's disease through a number of biological actions. This review examines studies of the role of estrogen-related factors in age at onset and risk for Alzheimer's disease in women with Down syndrome, a population at high risk for early onset of dementia. The studies are consistent in showing that early age at menopause and that low levels of endogenous bioavailable estradiol in postmenopausal women with Down syndrome are associated with earlier age at onset and overall risk for dementia...
August 31, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28827141/estetrol-a-fetal-selective-estrogen-receptor-modulator-acts-on-the-vagina-of-mice-through-nuclear-er%C3%AE-activation
#6
Thibaut Benoit, Marie-Cecile Valera, Coralie Fontaine, Melissa Buscato, Francoise Lenfant, Isabelle Raymond-Letron, Florence Tremollieres, Michel Soulie, Jean-Michel Foidart, Xavier Game, Jean-Francois Arnal
The genito-urinary syndrome of menopause has a negative impact on quality of life of postmenopausal women. The treatment of vulvo-vaginal atrophy (VVA) includes administration of estrogens. However, oral estrogen treatment is controversial due to its potential risks on venous thrombosis and breast cancer. Estetrol (E4) is a natural estrogen synthesized exclusively during pregnancy by the human fetal liver and initially considered as a weak estrogen. However, E4 was recently evaluated in a phase I-II clinical studies and found to act as an oral contraceptive in combination with a progestin, without increasing the level of coagulation factors...
August 18, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28826891/traditional-uses-phytochemistry-pharmacology-and-toxicology-of-the-genus-cimicifuga-a-review
#7
REVIEW
Yaqing Guo, Tong Yin, Xiaoming Wang, Fan Zhang, Guixiang Pan, Hong Lv, Xianrui Wang, John Owoicho Orgah, Yan Zhu, Honghua Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Plants of the genus Cimicifuga have long been used as an ethnomedicine in China, Europe, and North America for its high medicinal value and health benefits. Their dried rhizomes are widely used for treating wind-heat headache, toothache, aphtha, sore throat, measles, spot poison, archoptosis, and uterine prolapse. In addition, it is used as a dietary supplement for preventing women menopausal symptoms and osteoporosis. AIM OF THE REVIEW: This paper aims to provide up-to-date information on the genus Cimicifuga, including botanical characterization, medicinal resources, traditional medicinal uses, phytochemistry, quality control, pharmacological research as well as the toxicology...
August 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28807722/coronary-microvascular-dysfunction-is-not-associated-with-a-history-of-reproductive-risk-factors-in-women-with-angina-pectoris-an-ipower-substudy
#8
Hannah Elena Suhrs, Anna Meta Kristensen, Anna Bay Rask, Marie Mide Michelsen, Daria Frestad, Naja Dam Mygind, Kira Bové, Eva Prescott
BACKGROUND: Reproductive risk factors such as preeclampsia and recurrent miscarriages have been associated with adverse cardiovascular (CV) events. Underlying coronary microvascular dysfunction (CMD) may be a common denominator. PURPOSE: We investigated whether a history of reproductive risk factors was associated with CMD in women with angina pectoris and no obstructive coronary artery disease (CAD). METHODS: Participants from the iPOWER study, including women with angina pectoris and no obstructive CAD (<50% stenosis), were invited to complete an electronic survey regarding reproductive risk factors: recurrent miscarriages, gestational diabetes, preeclampsia, rhesus immunity, polycystic ovary syndrome and menopausal status as well as migraine and Raynaud phenomenon...
August 11, 2017: Maturitas
https://www.readbyqxmd.com/read/28807107/etiologies-and-management-of-cutaneous-flushing-nonmalignant-causes
#9
REVIEW
Azeen Sadeghian, Hailey Rouhana, Brittany Oswald-Stumpf, Erin Boh
The flushing phenomenon may represent a physiologic or a pathologic reaction. Although flushing is usually benign, it is prudent that the physician remains aware of potentially life-threatening conditions associated with cutaneous flushing. A thorough investigation should be performed if the flushing is atypical or not clearly associated with a benign underlying process. The diagnosis often relies on a pertinent history, review of systems, physical examination, and various laboratory and imaging modalities, all of which are discussed in the 2 articles in this continuing medical education series...
September 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28802473/integrative-women-s-health
#10
REVIEW
Delia Chiaramonte, Melinda Ring, Amy B Locke
This article addresses the common women's health concerns of menopause-related symptoms, premenstrual syndrome, and chronic pelvic pain. Each can be effectively addressed with an integrative approach that incorporates interventions such as pharmaceuticals, nutraceuticals, mind-body approaches, acupuncture, and lifestyle modification.
September 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/28796038/clomiphene-citrate-is-associated-with-favorable-cycle-characteristics-but-impaired-outcomes-of-obese-women-with-polycystic-ovarian-syndrome-undergoing-ovarian-stimulation-for-in-vitro-fertilization
#11
Shutian Jiang, Yanping Kuang
The aim of this study was to explore the effect of clomiphene citrate (CC) on the cycle characteristics and outcomes of obese women with polycystic ovarian syndrome (PCOS) undergoing ovarian stimulation for in vitro fertilization (IVF).This is a retrospective cohort study, and it was conducted at the tertiary-care academic medical center.This study included 174 obese PCOS patients undergoing IVF.In the study group (n = 90), CC and human menopausal gonadotropin (HMG) were administered simultaneously beginning on cycle day 3, while in control group (n = 84) HMG was used only...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28770400/microablative-fractional-co2-laser-for-the-genitourinary-syndrome-of-menopause-power-of-30-or-40%C3%A2-w
#12
Eleni Pitsouni, Themos Grigoriadis, Matthew Falagas, Angeliki Tsiveleka, Stefano Salvatore, Stavros Athanasiou
This retrospective case-control study aimed to compare 30 versus 40 W power of CO2 laser for the therapy of genitourinary syndrome of menopause (GSM). Postmenopausal women with severe intensity of dyspareunia and dryness were eligible to be included in this study. Primary outcomes were dyspareunia and dryness. Secondary outcomes were itching/burning, dysuria, frequency and urgency, Female Sexual Function Index (FSFI), vaginal maturation value (VMV), and Vaginal Health Index Score (VHIS). One laser therapy was applied every month for 3 months...
August 2, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28763403/relative-contribution-of-obesity-and-menopause-to-the-association-between-serum-adiponectin-and-incident-metabolic-syndrome
#13
Song Vogue Ahn, Dong-Hyuk Jung, Dhananjay Yadav, Jang-Young Kim, Sang-Baek Koh
OBJECTIVE: Metabolic syndrome is closely linked to obesity. Menopause may play a critical role in understanding the pathophysiology of metabolic syndrome in women. We investigated the relative contribution of obesity and menopause to the association between serum adiponectin levels and the development of metabolic syndrome. METHODS: A prospective cohort study was conducted in which a total of 1,219 women without metabolic syndrome were examined at baseline (2005-2008) and followed up (2008-2011)...
July 31, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28759461/lasers-for-pelvic-floor-dysfunctions-is-there-evidence
#14
Patrick Lang, Mickey Karram
PURPOSE OF REVIEW: The purpose of this review is to discuss the available energy sources used in the vaginal canal that are currently being promoted for certain pelvic floor conditions and explore the body of peer-reviewed literature supporting their use. RECENT FINDINGS: The majority of research has focused on the use of fractional CO2 laser treatment for genitourinary syndrome of menopause (GSM). Most of these studies are nonrandomized prospective studies, but their data consistently shows an improvement in symptoms without significant side effects...
July 29, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28746163/the-potential-contribution-of-dietary-factors-to-breast-cancer-prevention
#15
Niva Shapira
Breast cancer (BC), the leading cancer in women, is increasing in prevalence worldwide, concurrent with western metabolic epidemics, that is, obesity, metabolic syndrome, and diabetes, and shares major risk factors with these diseases. The corresponding potential for nutritional contributions toward BC prevention is reviewed and related to critical stages in the life cycle and their implications for carcinogenic and pathometabolic trajectories. BC initiation potentially involves diet-related pro-oxidative, inflammatory, and procarcinogenic processes, that interact through combined lipid/fatty acid peroxidation, estrogen metabolism, and related DNA-adduct/depurination/mutation formation...
September 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28731148/molecular-genetics-and-targeted-therapy-of-wnt-related-human-diseases-review
#16
Masuko Katoh, Masaru Katoh
Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the WNT/β-catenin and WNT/stabilization of proteins (STOP) signaling cascades to regulate cell fate and proliferation, whereas non-canonical WNT signaling through Frizzled or ROR receptors is transduced to the WNT/planar cell polarity (PCP), WNT/G protein-coupled receptor (GPCR) and WNT/receptor tyrosine kinase (RTK) signaling cascades to regulate cytoskeletal dynamics and directional cell movement. WNT/β-catenin signaling cascade crosstalks with RTK/SRK and GPCR-cAMP-PKA signaling cascades to regulate β-catenin phosphorylation and β-catenin-dependent transcription...
September 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28721129/anti-m%C3%A3-llerian-hormone-amh-as-a-good-predictor-of-time-of-menopause
#17
REVIEW
Aleksandra Kruszyńska, Jadwiga Słowińska-Srzednicka
Anti-Müllerian hormone (AMH) in women is secreted by granulosa cells in late preantral and small antral follicles. AMH seems to be a very stable marker having some advantages over other biochemical and biophysical markers and is very useful in the assessment of ovarian reserve. AMH measurement may be used in cases of premature ovarian failure, including iatrogenic, due to treatment for cancer, hypogonadotropic hypogonadism, and lastly, in polycystic ovary syndrome (PCOS). It is also a very specific marker of ovarian tumors - folliculomas...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28709892/liuwei-dihuang-soft-capsules-attenuates-endothelial-cell-apoptosis-to-prevent-atherosclerosis-through-gpr30-mediated-regulation-in-ovariectomized-apoe-deficient-mice
#18
Yi Jing, Danfeng Cai, Qi Chen, Qingping Xiong, Tianhui Hu, Yuan Yao, Chao Lin, Xin Sun, Ying Lu, Xueyun Kong, Xiang Wu, Yu Li, Huimin Bian
ETHNOPHARMACOLOGICAL RELEVANCE: Liuwei Dihuang (LWDH), a classical traditional Chinese medicine prescription, has been widely used to prevent and to treat various diseases with symptoms of 'Kidney-Yin' deficiency syndrome for over 1000 years in China. It is commonly used to treat functional decline associated with senile disease and menopausal syndrome, especially memory decline, insomnia, diabetes and osteoporosis. Modern experimental pharmacological studies indicated that the mechanism of LWDH treatment of menopausal syndrome may be associated with enhanced estrogenic effects...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28706404/dry-eye-syndrome-in-menopause-and-perimenopausal-age-group
#19
REVIEW
Travis Peck, Leslie Olsakovsky, Shruti Aggarwal
Dry eye disease (DED) is a multifactorial ocular surface disease that causes symptoms of ocular pain, discomfort, and decreased visual acuity. It significantly affects quality of life of patients. It is more prevalent in the females and is being specifically in the menopausal and postmenopausal age group. This is believed to be due to the changes in balance of sex hormones. Sex hormones - estrogens and androgens - influence production of all components of the tear film including aqueous layer, lipid, and mucin...
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28701499/breastfeeding-ovulatory-years-and-risk-of-multiple-sclerosis
#20
Annette Langer-Gould, Jessica B Smith, Kerstin Hellwig, Edlin Gonzales, Samantha Haraszti, Corinna Koebnick, Anny Xiang
OBJECTIVE: To determine whether women who breastfeed their infants longer or have fewer ovulatory years are at lower risk of developing multiple sclerosis (MS). METHODS: We recruited women with newly diagnosed MS or its precursor, clinically isolated syndrome (CIS) (n = 397), and matched controls (n = 433) into the MS Sunshine Study from the membership of Kaiser Permanente Southern California. A structured in-person questionnaire was administered to collect the behavioral (pregnancies, breastfeeding, hormonal contraceptive use) and biological (age at menarche and menopause, amenorrhea) factors to make up ovulatory years...
August 8, 2017: Neurology
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