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https://www.readbyqxmd.com/read/27912959/chinese-herbal-medicine-kuntai-capsule-for-treatment-of-menopausal-syndrome-a-systematic-review-of-randomized-clinical-trials
#1
REVIEW
Quan Zhou, Jing Tao, Huamei Song, Aihua Chen, Huaijie Yang, Manzhen Zuo, Hairong Li
OBJECTIVES: Kuntai capsule has been widely used for the treatment of menopausal syndrome in China for long time. We conducted this review to assess efficacy and safety of Kuntai capsule for the treatment of menopausal syndrome. METHODS: We searched studies in PubMed, ClinicalTrials, the Cochrane Library, China National Knowledge Infrastructure Database(CNKI), China Science and Technology Journal Database (VIP), Wan fang Database and Chinese Biomedical Literature Database(CBM) until November 20, 2014...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27912889/hormone-replacement-therapy-in-young-women-with-primary-ovarian-insufficiency-and-early-menopause
#2
REVIEW
Shannon D Sullivan, Philip M Sarrel, Lawrence M Nelson
Primary ovarian insufficiency (POI) is a rare but important cause of ovarian hormone deficiency and infertility in women. In addition to causing infertility, POI is associated with multiple health risks, including bothersome menopausal symptoms, decreased bone density and increased risk of fractures, early progression of cardiovascular disease, psychologic impact that may include depression, anxiety, and decreased perceived psychosocial support, potential early decline in cognition, and dry eye syndrome. Appropriate hormone replacement therapy (HRT) to replace premenopausal levels of ovarian sex steroids is paramount to increasing quality of life for women with POI and ameliorating associated health risks...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27900987/effect-of-half-dose-and-standard-dose-conjugated-equine-estrogens-combined-with-natural-progesterone-or-dydrogesterone-on-components-of-metabolic-syndrome-in-healthy-postmenopausal-women-a-randomized-controlled-trial
#3
Wei Xue, Yan Deng, Yan-Fang Wang, Ai-Jun Sun
BACKGROUND: Menopausal hormone therapy (MHT) has been proven to have beneficial effects on several components of metabolic syndrome. However, the effects vary according to different regimens, dosages, and duration of MHT. The aim of the study was to evaluate the effect of standard-dose 0.625 mg conjugated equine estrogen (CEE) and half-dose 0.3 mg CEE daily with different progestogens in a continuous sequential regimen on postmenopausal metabolic parameters in generally healthy postmenopausal women...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27884793/sex-stress-and-sleep-apnoea-decreased-susceptibility-to-upper-airway-muscle-dysfunction-following-intermittent-hypoxia-in-females
#4
REVIEW
Ken D O'Halloran, Philip Lewis, Fiona McDonald
Obstructive sleep apnoea syndrome (OSAS) is a devastating respiratory control disorder more common in men than women. The reasons for the sex difference in prevalence are multifactorial, but are partly attributable to protective effects of oestrogen. Indeed, OSAS prevalence increases in post-menopausal women. OSAS is characterized by repeated occlusions of the pharyngeal airway during sleep. Dysfunction of the upper airway muscles controlling airway calibre and collapsibility is implicated in the pathophysiology of OSAS, and sex differences in the neuro-mechanical control of upper airway patency are described...
November 21, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27881911/systematic-review-and-meta-analysis-of-randomized-controlled-trials-on-wenxin-keli
#5
REVIEW
Xiaoyi Wang, Ying Wang, Xiaoyuan Feng, Ying Lu, Yu Zhang, Wenwen Wang, Wentao Zhu
OBJECTIVE: The aim of the study was to evaluate the effectiveness, safety, and cost associated with Wenxin keli in the treatment of cardiovascular diseases based on meta-analysis. METHODS: The terms "Wenxin keli" and "Wenxin" were used as the search terms in the PubMed, ProQuest, Springer, the Cochrane Library, CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientific Journals Database), and Wan fang electronic databases (from January 2000 to October 2015)...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27879963/hypogonadism-and-non-alcoholic-fatty-liver-disease
#6
Gesthimani Mintziori, Pavlos Poulakos, Christos Tsametis, Dimitrios G Goulis
Non-alcoholic fatty liver disease (NAFLD) is more common in men than in women. Thus, it has been suggested that sex steroids do have a role in the development of NAFLD. The aim of the current paper is to illustrate the association between NAFLD and hypogonadism, by reviewing data derived from both human and animal studies. The prevalence of NAFLD is high in men with hypogonadism, including those with idiopathic hypogonadotropic hypogonadism (IHH), as well as in women in post- menopause, those under estrogen receptor antagonist treatment or women with Turner syndrome...
November 23, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27876429/can-polyacrylic-acid-treat-sexual-dysfunction-in-women-with-breast-cancer-receiving-tamoxifen
#7
P T Juliato, A T Rodrigues, R Stahlschmidt, C R T Juliato, P G Mazzola
OBJECTIVE: There is a lack of safety data supporting the use of hormone therapy in women who have had breast cancer and who have complained of genitourinary syndrome of menopause (GSM). The objective was to test the efficacy of two non-hormonal therapies for vaginal dryness. METHODS: This was a randomized trial with 52 women with breast cancer who were being treated with tamoxifen and who complained of vaginal dryness. The volunteers answered two questionnaires to evaluate sexual function (Female Sexual Function Index, FSFI) and a customized GSM questionnaire...
November 23, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27871904/steroidogenic-effect-of-erxian-decoction-for-relieving-menopause-via-the-p-akt-pkb-pathway-in-vitro-and-in-vivo
#8
Shi Wei Wang, Ho Pan Cheung, Yao Tong, Jia Lu, Tzi Bun Ng, Yan Bo Zhang, Zhang Jin Zhang, Kai Fai Lee, Jenny Ka Wing Lam, Stephen Cho Wing Sze
ETHNOPHARMACOLOGICAL RELEVANCE: Erxian decoction (EXD), an empirical Chinese medicine formula, is effectively used in the clinical treatment of menopause-related symptoms in China. Previous data from our group show that EXD has steroidogenic effect in natural menopausal Sprague-Dawley-rats (SD-rats) as an animal model of menopause. However, the mechanistic studies on steroidogenic effects of EXD are still inadequate. Hence, the mechanisms of steroidogenic effects of EXD were studied in vitro and in vivo in this study...
November 18, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27864031/fractional-co2-laser-treatment-of-the-vestibule-for-patients-with-vestibulodynia-and-genitourinary-syndrome-of-menopause-a-pilot-study
#9
Filippo Murina, Mickey Karram, Stefano Salvatore, Raffaele Felice
INTRODUCTION: Chronic vulvar pain and burning remains one of the most perplexing problems faced by practicing gynecologists. AIM: To evaluate the effectiveness and safety of the application of micro-ablative fractional CO2 laser to the vulvar vestibule in the management of patients with vulvar pain from vestibulodynia or genitourinary syndrome of menopause. METHODS: Patients (N = 70) underwent fractional micro-ablative CO2 laser treatment for vestibular pain plus vestibulodynia (n = 37) or genitourinary syndrome of menopause (n = 33)...
November 15, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27861765/genetics-of-primary-ovarian-insufficiency
#10
REVIEW
R Rossetti, I Ferrari, M Bonomi, L Persani
Primary ovarian insufficiency (POI) is characterized by a loss of ovarian function before the age of 40 and account for one major cause of female infertility. POI relevance is continuously growing because of the increasing number of women desiring conception beyond 30 years of age, when POI prevalence is >1%. POI is highly heterogeneous and can present with ovarian dysgenesis and primary amenorrhea, or with secondary amenorrhea, and it can be associated with other congenital or acquired abnormalities. In most cases POI remains classified as idiopathic...
November 16, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27855428/middle-aged-female-depression-in-perimenopausal-period-and-square-dance-intervention
#11
Lei Gao, Linlin Zhang, Hua Qi, Louyis Petridis
BACKGROUND: Depression is one of the most common psychiatric illnesses among perimenopausal women. Currently, drug treatments for the disorder tend to have higher risks than other forms of treatment. On the contrary, aerobic exercise can effectively relieve menopausal syndrome among perimenopausal women. Square dance, a kind of aerobic exercise favored by middle-aged women in China, could be a beneficial intervention for perimenopausal depression. SUBJECTS AND METHODS: A total of 321 women in perimenopause were chosen from Nangang Community, DaoLi Community, and Daowai Community in Harbin, Heilongjiang Province, from September 2015 through April 2016...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27845267/protective-effects-and-mechanisms-investigation-of-kuntai-capsule-on-the-ovarian-function-of-a-novel-model-with-accelerated-aging-ovaries
#12
Jinjin Zhang, Li Fang, Liangyan Shi, Zhiwen Lai, Zhiyong Lu, Jiaqiang Xiong, Meng Wu, Aiyue Luo, Shixuan Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Kuntai capsule, a traditional Chinese medicine, has been widely used for the clinical treatment of menopausal syndrome. However, its mechanisms remain poorly understood. Considering that aging ovaries are the primary cause of menopause, this study was designed to investigate the effects and mechanisms of Kuntai capsule on ovarian function in a novel mice model with accelerated aging ovaries. MATERIALS AND METHODS: Seventy-five female C57BL/6 mice were chosen for this study...
November 11, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27832862/time-restricted-feeding-improves-insulin-resistance-and-hepatic-steatosis-in-a-mouse-model-of-postmenopausal-obesity
#13
Heekyung Chung, Winjet Chou, Dorothy D Sears, Ruth E Patterson, Nicholas J G Webster, Lesley G Ellies
BACKGROUND: Menopause is associated with significant hormonal changes that result in increased total body fat and abdominal fat, amplifying the risk for metabolic syndrome and diseases such as diabetes, cardiovascular disease and cancer in postmenopausal women. Intermittent fasting regimens hold significant health benefit promise for obese humans, however, regimens that include extreme daytime calorie restriction or daytime fasting are generally associated with hunger and irritability, hampering long-term compliance and adoption in the clinical setting...
December 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27823733/microablative-fractional-co2-laser-therapy-and-the-genitourinary-syndrome-of-menopause-an-observational-study
#14
Eleni Pitsouni, Themos Grigoriadis, Angeliki Tsiveleka, Dimitris Zacharakis, Stefano Salvatore, Stavros Athanasiou
OBJECTIVES: This study aimed to assess the effect of the Microablative Fractional CO2 Laser (CO2-laser) therapy on vaginal pathophysiology and the symptoms of the Genitourinary Syndrome of Menopause (GSM). METHODS: Postmenopausal women with moderate to severe symptoms of GSM underwent three sessions of CO2-laser therapy at monthly intervals. Participants were evaluated at baseline and 4 weeks after the last treatment. MAIN OUTCOME MEASURES: The primary outcomes were Vaginal Maturation Value (VMV) and Vaginal Health Index Score (VHIS)...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27816231/distribution-of-the-fmr1-gene-in-females-by-race-ethnicity-women-with-diminished-ovarian-reserve-versus-women-with-normal-fertility-swan-study
#15
Lisa M Pastore, Steven L Young, Ani Manichaikul, Valerie L Baker, Xin Q Wang, Joel S Finkelstein
OBJECTIVE: To study whether reported, but inconsistent, associations between the FMR1 CGG repeat lengths in the intermediate, high normal, or low normal range differentiate women diagnosed with diminished ovarian reserve (DOR) from population controls and whether associations vary by race/ethnic group. DESIGN: Case-control study. SETTING: Academic and private fertility clinics. PATIENT(S): DOR cases (n = 129; 95 Whites, 22 Asian, 12 other) from five U...
November 2, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27798047/common-diseases-as-determinants-of-menopausal-age
#16
Jingmei Li, Mikael Eriksson, Kamila Czene, Per Hall, Kenny A Rodriguez-Wallberg
STUDY QUESTION: Can the diagnosis of common diseases before menopause influence age at natural menopause (ANM) onset? SUMMARY ANSWER: Polycystic ovary syndrome (PCOS) and depression were observed to delay menopause. WHAT IS KNOWN ALREADY: It has been observed that women who undergo early menopause experience a higher burden of health problems related to metabolic syndromes, heart disease and depression, but whether ANM can be influenced by common adult diseases has not been studied extensively...
October 18, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27795759/paraneoplastic-syndromes-revealing-ovarian-teratoma-in-young-and-menopausal-women-report-of-two-cases
#17
Majdouline Boujoual, Ihsan Hakimi, Farid Kassidi, Youssef Akhoudad, Nawal Sahel, Adil Rkiouak, Mohamed Allaoui, Hafsa Chahdi, Mohamed Oukabli, Jaouad Kouach, Driss Rahali Moussaoui, Mohamed Dehayni
Paraneoplastic syndromes are a heterogeneous group of clinical and biological manifestations caused by underling neoplasms. They can reveal ovarian teratoma which express neuroendocrine proteins, or contain mature or immature neural tissue inducing an autoimmune response. The etiological investigation is then crucial to early identification of the tumor in order to optimize the prognosis and to limit neurological sequelae. In case of ovarian teratoma, management is essentially based on surgical resection sometimes associated with immunotherapie...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27776458/the-effects-of-exercise-on-mastalgia
#18
Aysun Genç, Mehmet Mesut Çelebi, Süleyman Utku Çelik, Ebru Düşünceli Atman, Akın Fırat Kocaay, Ali Murat Zergeroğlu, Atilla Halil Elhan, Volkan Genç
OBJECTIVE: Mastalgia is often ignored by physicians although it is the most common breast-related complaint among women. The effectiveness of exercise therapy for mastalgia is unclear. The aim of this study is to investigate the effects of exercise on mastalgia. METHODS: A randomized controlled trial was conducted with twenty women with complaints of mastalgia fulfilling the inclusion and exclusion criteria. Patients were randomly assigned to the control group and to the exercise group...
October 25, 2016: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/27760084/effect-of-gua-sha-therapy-on-perimenopausal-syndrome-a-randomized-controlled-trial
#19
Fang Meng, Pei-Bei Duan, Junya Zhu, Qing-Qing Lou, Zhao-Hui Fang, Hong-Li An, Lan-Ying Liu, Yue Hu, Qian Hu
OBJECTIVE: This study aims to evaluate the effectiveness and safety of Gua sha therapy on perimenopausal symptoms, quality of life, and serum female hormones in participants with perimenopausal syndrome. METHODS: A prospective, randomized, controlled clinical trial was conducted at the First Affiliated Hospital of Nanjing University of Chinese Medicine in China. Eighty women with perimenopausal syndrome were recruited and randomized into an intervention group or a control group...
October 10, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27749218/serum-calprotectin-is-a-biomarker-of-carotid-atherosclerosis-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#20
Gabriela M Balarini, Eliana Zandonade, Leandro Tanure, Gilda A Ferreira, Wildner M Sardenberg, Érica V Serrano, Cleia C Dias, Túlio P Navarro, Hilde H Nordal, Piotr M Mydel, Johan G Brun, Karl A Brokstad, Eva Gerdts, Roland Jonsson, Valéria Valim
OBJECTIVES: We aimed to identify the association of carotid atherosclerosis with the traditional risk factors, disease features, cytokine profile, and calprotectin in patients with primary Sjögren's syndrome (pSS). METHODS: 63 primary pSS patients and 63 age- and sex-matched healthy controls underwent carotid ultrasound, clinical and laboratory examination. The presence of carotid plaques was taken as carotid atherosclerosis. The covariates of carotid atherosclerosis were identified in univariate and multivariate regressions...
September 8, 2016: Clinical and Experimental Rheumatology
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