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https://www.readbyqxmd.com/read/29328968/in-vitro-examination-of-an-oleosome-based-sun-protection-product-on-the-influence-of-uvb-induced-inflammation-markers-in-human-epidermal-skin-equivalent-tissue-model
#1
James V Gruber, Robert Holtz, Soo In Yang
In vitro human epidermal skin equivalent tissues (MatTek EpiDerm™) were employed to examine the influence of UVB radiation on various established inflammation markers in the presence of topically applied sunscreens. MatTek EpiDerm™ tissues were treated with 2.0mg/cm2 of an Experimental oleosome-based SPF 30 product or a commercial SPF 30 beach product. Tissues were irradiated with 300mJ/cm2 of UVB radiation. Inflammatory cytokines IL-1α, IL-6 and IL-8 as well as arachidonic acid cascade marker PGE2 were examined via ELISA-based antibody detection...
December 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29323251/vitamin-e-inhibits-the-uvai-induction-of-light-and-dark-cyclobutane-pyrimidine-dimers-and-oxidatively-generated-dna-damage-in-keratinocytes
#2
George J Delinasios, Mahsa Karbaschi, Marcus S Cooke, Antony R Young
Solar ultraviolet radiation (UVR)-induced DNA damage has acute, and long-term adverse effects in the skin. This damage arises directly by absorption of UVR, and indirectly via photosensitization reactions. The aim of the present study was to assess the effects of vitamin E on UVAI-induced DNA damage in keratinocytes in vitro. Incubation with vitamin E before UVAI exposure decreased the formation of oxidized purines (with a decrease in intracellular oxidizing species), and cyclobutane pyrimidine dimers (CPD)...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320597/realistic-sunscreen-durability-a-randomized-double-blinded-controlled-clinical-study
#3
Hao Ouyang, Karen Meyer, Prithwiraj Maitra, Susan Daly, Ryan M Svoboda, Aaron S Farberg, Darrell S Rigel
BACKGROUND: Studies show that sunscreen under real-life conditions is often not reapplied and/or applied insufficiently. This study investigated the durability of 2 current sunscreens with different SPF protection over an 8-hour period under simulated real-life conditions. METHODS: Participants (n=24) were randomized into two study groups utilizing either 2 mg/cm2 (FDA testing concentration) or 1 mg/cm2 (real-life application levels) of sunscreen. Two current SPF 15 and 70 sunscreens were applied to test spots on each participant's back...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29320596/double-blind-placebo-controlled-evaluation-of-a-novel-skin-lightening-agent
#4
James M Spencer, Julianna Accioly, Neal Kitchen
Melasma remains a troubling problem for physicans and patients alike. It is a chronic irregular, symmetric hyperpigmentation seen most often in women. In this study, a unique combination of ingredients with non-irritating properties was tested for treatment of melasma. In a double blind, placebo controlled, split face trial, 17 patients with melasma were treated on one half of the face, left or right, while the other received placebo control. All patients used sunscreen on both sides. Measurement with a colorimeter (Mexameter) was taken at baseline and after 8 weeks of daily use...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29320342/factors-associated-with-sunbed-use-in-women-the-e3n-sunexp-study
#5
Isabelle Savoye, Iris Cervenka, Yahya Mahamat Saleh, Marie-Christine Boutron-Ruault, Marina Kvaskoff
OBJECTIVES: In this study, we attempt to describe the profile of sunbed users among cancer-free French women. METHODS: E3N is a prospective cohort including 98,995 French women aged 40- 65 years in 1990. In 2008, a specific UV questionnaire was sent to all reported skin cancer cases and 3 controls per case, matched on age, county of birth, and education. We used logistic regression models adjusted for pigmentary traits. RESULTS: Compared with non-users, ever-users of sunbeds were younger (ptrend < ...
January 1, 2018: American Journal of Health Behavior
https://www.readbyqxmd.com/read/29318983/prevalence-and-determinants-of-vitamin-d-deficiency-in-the-third-trimester-of-pregnancy-a-multicentre-study-in-switzerland
#6
Jean-Philippe Krieger, Sophie Cabaset, Claudia Canonica, Ladina Christoffel, Aline Richard, Therese Schröder, Begoña Lipp von Wattenwyl, Sabine Rohrmann, Katharina Quack Lötscher
Vitamin D deficiency during pregnancy is associated with negative health consequences for mothers and their infants. Data on the vitamin D status of pregnant women in Switzerland are scarce. A three-centre study was conducted in the obstetric departments of Zurich, Bellinzona and Samedan (Switzerland) to investigate the prevalence and determinants of vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D)<50 nmol/l) in 3rd-trimester pregnant women living in Switzerland (n 305), and the correlation between 25(OH)D in pregnant women and their offspring at birth (n 278)...
January 10, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29318223/investigating-isomer-specific-photoprotection-in-a-model-plant-sunscreen
#7
M D Horbury, A L Flourat, S E Greenough, F Allais, V G Stavros
Sinapate esters are used throughout the plant kingdom, for example in photoprotection from ultraviolet radiation. Sinapate esters are naturally produced in their E-isomeric form; however, upon exposure to ultraviolet radiation, photoisomerization drives Z-isomer formation. To elucidate the photoprotection capacity of E vs. Z forms of sinapate esters, we explore the photochemistry of the model system, Z-ethyl sinapate. Following a novel Z-ethyl sinapate synthesis, we demonstrate that photoprotection is isomer independent...
January 10, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29317738/personal-care-product-use-as-a-predictor-of-urinary-concentrations-of-certain-phthalates-parabens-and-phenols-in-the-hermosa-study
#8
Kimberly P Berger, Katherine R Kogut, Asa Bradman, Jianwen She, Qi Gavin, Rana Zahedi, Kimberly L Parra, Kim G Harley
Use of personal care products, such as makeup, soaps, and sunscreen, may expose adolescent girls to potential endocrine disruptors, including phthalates, parabens, and other phenols. We evaluated the relationship between recent self-reported personal care product use and concentrations for urinary metabolites of phthalates, parabens, triclosan, and benzophenone-3 (BP-3) in 100 Latina adolescents. Girls who reported using makeup every day vs. rarely/never had higher urinary concentrations of monoethyl phthalate (MEP) (102...
January 9, 2018: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29313300/the-effect-of-educational-intervention-based-on-health-belief-model-and-social-support-on-promoting-skin-cancer-preventive-behaviors-in-a-sample-of-iranian-farmers
#9
Ali Khani Jeihooni, Tayebeh Rakhshani
Skin cancer is one of the most common cancers in Iran. Farmers are exposed to the sun's ultraviolet radiation due to their job and are susceptible to skin cancer. The aim of this study is to survey the effect of educational intervention based on health belief model and social support on promoting skin cancer preventive behaviors in farmers of Fasa City, Fars province, Iran. In this quasi-experimental study, 200 farmers (100 in experimental group and 100 in control group) in Fasa City, Fars, Iran, were selected in 2017...
January 8, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29311040/prevalence-and-risk-factors-of-actinic-keratosis-in-patients-attending-italian-dermatology-clinics
#10
Maria Concetta Fargnoli, Gianfranco Altomare, Elisa Benati, Francesco Borgia, Paolo Broganelli, Anna Carbone, Sergio Chimenti, Sergio Donato, Giampiero Girolomoni, Giuseppe Micali, Erica Moggio, Aurora Parodi, Stefano Piaserico, Giuseppe Pistone, Concetta Potenza, Mario Puviani, Margherita Raucci, Sabina Vaccari, Stefano Veglio, Andrea Zanca, Ketty Peris
Actinic keratosis (AK) is a common keratinocyte intra-epidermal neoplasia. To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented...
December 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29304277/photosynthetic-production-of-sunscreen-shinorine-using-an-engineered-cyanobacterium
#11
Guang Yang, Monica A Cozad, Destin A Holland, Yi Zhang, Hendrik Luesch, Yousong Ding
Mycosporine-like amino acids (MAAs) are secondary metabolites of a variety of marine organisms including cyanobacteria and macroalgae. These compounds have strong ultraviolet (UV) absorption maxima between 310 and 362 nm and are biological sunscreens for counteracting the damaging effects of UV radiation in nature. The common MAA shinorine has been used as one key active ingredient of environmentally friendly sunscreen creams. Commercially used shinorine is isolated from one red algae that is generally harvested from the wild...
January 5, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29303476/are-cancer-survivors-following-the-national-comprehensive-cancer-network-health-behavior-guidelines-an-assessment-of-patients-attending-a-cancer-survivorship-clinic
#12
Kelly A Hyland, Jamie M Jacobs, Inga T Lennes, William F Pirl, Elyse R Park
PURPOSE: Engaging in positive health behaviors post-treatment is important for cancer survivors' health. However, little is known about whether survivors are practicing health promoting behaviors. We aimed to explore whether survivors are meeting the recent health behavior guidelines set forth by the National Comprehensive Cancer Network (NCCN) and to examine associations between health behaviors and distress. METHODS: Sixty-six survivors completed a cross-sectional questionnaire assessing health behaviors prior to an initial appointment at a survivorship care clinic...
January 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29289926/the-use-of-suction-blisters-to-measure-sunscreen-protection-against-uvr-induced-dna-damage
#13
Gwendal Josse, Thierry Douki, Jimmy Le Digabel, Eleonore Gravier, Emmanuel Questel
The formation of DNA photoproducts caused by solar UVR exposure needs to be investigated in-vivo and in particular in order to assess sunscreens' level of protection against solar genotoxicity. The study's purposes were: i) to evaluate if the roof of suction blisters is an appropriate sampling method for measuring photoproducts, and ii) to measure in-vivo sunscreen protection against cyclobutane pyrimidine dimers. Skin areas on the interior forearms of eight healthy volunteers were exposed in-vivo to 2 MED of simulated solar radiation (SSR) and to 15 MED on a sunscreen protected area...
December 22, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29289284/exposure-to-endocrine-disrupting-chemicals-perturbs-lipid-metabolism-and-circadian-rhythms
#14
Renate Kopp, Irene Ozáez Martínez, Jessica Legradi, Juliette Legler
A growing body of evidence indicates that exposure to environmental chemicals can contribute to the etiology of obesity by inappropriately stimulating adipogenesis as well as perturbing lipid metabolism and energy balance. One potential mechanism by which chemical exposure can influence lipid metabolism is through disturbance of circadian rhythms, endogenously-driven cycles of roughly 24hr in length that coordinate biochemical, physiological, and behavioral processes in all organisms. Here we show for the first time that exposure to endocrine disrupting compounds (EDCs), including the pesticide tributyltin, two commercial flame retardants, and a UV-filter chemical found in sunscreens, can perturb both circadian clocks and lipid metabolism in vertebrates...
December 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29288547/photophysics-of-a-uv-b-filter-4-methylbenzylidene-camphor-intersystem-crossing-plays-an-important-role
#15
Ganglong Cui, Ye-Guang Fang, Chun-Xiang Li, Xue-Ping Chang
4-methylbenzylidene camphor 4MBC is a frequently used ultraviolet (UV) filter in commercial sunscreens, which is experimentally found to undergo efficient intersystem crossing to triplet manifolds followed by predominant radiationless decay to ground state. However, its photophysical mechanism is unclear. Herein we have employed combined CASPT2 and CASSCF methods to study spectroscopic properties, and excited-state deactivation channels of 4MBC. We have found that the V(1pp∗) state is populated with large probability in the Franck-Condon region...
December 30, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29287765/mechanisms-of-aging-and-development-a-new-understanding-of-environmental-damage-to-the-skin-and-prevention-with-topical-antioxidants
#16
REVIEW
Karen E Burke
Recent research has given us new insights into the molecular biology of extrinsic aging of the skin. Not only does UV irradiation directly cause photoaging of the skin, but also environmental pollutants significantly damage exposed skin by several mechanisms. Exposure to the noxious gases of air pollution with simultaneous exposure to UVA can act synergistically to initiate skin cancer. Also ozone generated from pollutants reacting with UV induces oxidative stress of the skin's surface via formation of lipid peroxidation products, with cascading consequences to deeper layers...
December 26, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29282394/treatment-of-multiple-actinic-keratosis-and-field-of-cancerization-with-topical-piroxicam-0-8-and-sunscreen-50-in-organ-transplant-recipients-a-series-of-10-cases
#17
Virginia Garofalo, Alessandra Ventura, Sara Mazzilli, Laura Diluvio, Luca Bianchi, Luca Toti, Giuseppe Tisone, Massimo Milani, Elena Campione
Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Treatment of the field of cancerization is also crucial to reduce the risk of recurrence of skin lesions in AK and non-melanoma skin cancer patients. Activation of cyclooxygenase 1 and 2 enzymes plays an important role in the pathogenesis of skin cancers...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29258457/photosensitive-lichenoid-skin-reaction-to-capecitabine
#18
Rena A Shah, Daniel D Bennett, Mark E Burkard
BACKGROUND: Capecitabine is an oral prodrug of fluorouracil, which is a common agent used in the management of many solid tumor malignancies. Dermatologic reaction is common with various chemotherapy agents but is not commonly reported in the use of capecitabine. When adverse reactions of rashes occur, the offending agent is typically removed. We report here an unusual case of photosensitive lichenoid rash due to capecitabine which is managed conservatively without major alteration in treatment...
December 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29250640/nonradiative-dynamics-determined-by-charge-transfer-induced-hydrogen-bonding-a-combined-femtosecond-time-resolved-fluorescence-and-density-functional-theoretical-study-of-methyl-dimethylaminobenzoate-in-water
#19
Chensheng Ma, Yue-Qun Ou, Chris Tsz-Leung Chan, Allen Ka-Wa Wong, Ruth Chau-Ting Chan, Bowie Po-Yee Chung, Chao Jiang, Ming-Liang Wang, Wai-Ming Kwok
As a case study of the interplay and the consequence of the interplay between intramolecular charge transfer (ICT) and intermolecular hydrogen (H)-bonding, a combined femtosecond time-resolved fluorescence (fs-TRF) and density functional theoretical (DFT) and time-dependent DFT (TDDFT) study has been conducted on methyl dimethylaminobenzoate (MDMABA) largely in a water solvent. Direct observation of the broadband spectra, anisotropy, and kinetic decays of fs-TRF from photo-excited MDMABA revealed a rapid ICT reaction occurring with a time constant of ∼0...
December 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29247508/understanding-sunscreen-spf-performance-using-cross-polarized-uva-reflectance-photography
#20
J M Crowther
OBJECTIVE: Objective methods for understanding sunscreen behaviour in vitro before they are applied to the skin have failed to keep pace with the ever-increasing demands for higher SPF scores where the products are absorbing more and more similar levels of UV. A novel method for visualizing the spreading and location of SPF ingredients based on cross polarized UVA reflectance photography is described here which gives new insights into the formation of final film morphology and how it correlates with in vivo SPF efficacy for a set of test products...
December 16, 2017: International Journal of Cosmetic Science
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