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https://www.readbyqxmd.com/read/28718005/sunscreens-block-cutaneous-vitamin-d-production-with-only-a-minimal-effect-on-circulating-25-hydroxyvitamin-d
#1
Florence Libon, Justine Courtois, Caroline Le Goff, Pierre Lukas, Neus Fabregat-Cabello, Laurence Seidel, Etienne Cavalier, Arjen F Nikkels
A 50+ SPF sunscreen decreased significantly cutaneous vitamin D production following a single narrow-band (nb)UVB exposure, independently from the body surface area exposed. In contrast, the circulating 25(OH)D3 levels were only minimally affected. It is probable that another endogenous source of precursors is selected when skin-originated precursors are lacking. PURPOSE: Sunscreen use, highly advocated for preventing cutaneous carcinogenesis, is potentially leading to an aggravation of vitamin D deficiency with its consequences on bone health...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28715765/impact-of-coated-tio2-nanoparticles-used-in-sunscreens-on-two-representative-strains-of-the-human-microbiota-effect-of-the-particle-surface-nature-and-aging
#2
Laura Rowenczyk, Cécile Duclairoir-Poc, Magalie Barreau, Céline Picard, Nicolas Hucher, Nicole Orange, Michel Grisel, Marc Feuilloley
The impact of two differently coated TiO2-nanoparticles (NPs) was evaluated on two representative bacteria from the cutaneous microbiota (Staphylococcus aureus and Pseudomonas fluorescens) in conditions of use. Particles were coated in order to exhibit either hydrophilic or hydrophobic behavior. A first exposure scenario within some fresh/aged model emulsions was developed in order to measure both the impact of the NPs presence and their surface nature during the emulsions conservation. Thanks to this protocol, it was demonstrated that, during aging, the hydrophobic NPs modified the physicochemical characteristics of the emulsions, such as the pH or the colloids sizes, and favored the development of potential pathogenic bacteria...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28715165/relaxing-school-suncreen-restrictions
#3
Joellen Kralik
(1) Utah, Delaware, Vermont, Minnesota and Idaho have the highest skin cancer rates of all U.S. states, according to the Centers for Disease Control and Prevention. (2) Sunscreen is regulated by the U.S. Food and Drug Administration because it makes a "drug claim"--that it helps prevent sunburn and decreases the risks of skin cancer and early skin aging caused by the sun. (3) In Europe and some other countries, sunscreens are regulated as cosmetics, not as drugs.
July 2017: NCSL Legisbrief
https://www.readbyqxmd.com/read/28711091/update-on-sunscreens-distributed-by-major-us-retailers-that-meet-american-academy-of-dermatology-recommendations
#4
Ariel E Eber, Frances M Walocko, John Tsatalis, Marina Perper, Jessica Cervantes, Siri Choragudi, Keyvan Nouri
No abstract text is available yet for this article.
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28710584/associations-between-sun-exposure-and-other-lifestyle-variables-in-swedish-women
#5
R Scragg, S Sandin, M Löf, H-O Adami, E Weiderpass
PURPOSE: Sun exposure is associated with risk of several chronic diseases including cancer. The study aim is to investigate whether sun behaviors are related to other lifestyle risk factors of cancer. METHODS: We analyzed data collected in 2003-2004 by self-completed questionnaire from 34,402 Swedish women aged 40-61 years, who comprised 70% of a cohort of originally recruited from a population registry in 1991-1992 (n = 49,259). Participants were asked about annual number of sunburns and annual number of weeks of swimming and sunbathing during 1991-2002, solarium use during 1991-1998 and current sunscreen use...
July 14, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28707716/paraneoplastic-systemic-lupus-erythematosus-in-association-with-oat-cell-tumour-of-the-lung
#6
Yora Mostmans, Martine Grosber, Arlette De Coninck, Johannes Ring, Jan Gutermuth
A 63-year-old man presented in the emergency department with general malaise, asthenia, an erythematosquamous rash on face and forearms and severe hyponatremia. The rash appeared after working in his garden on a sunny afternoon without sunscreen protection (Figure 1A/B/C). Furosemide was stopped and once daily mometason furoate cream was prescribed. Hyponatremia was corrected by IV hypertonic fluids. Five days later, the rash spread to the upper legs, chest and back. Histopathology revealed damage of the basal layer with necrotic keratinocytes and dermal perivascular and adnexal infiltrates (Figure 2)...
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28704989/in-vitro-study-of-the-influence-of-octocrylene-on-a-selected-metastatic-melanoma-cell-line
#7
Tanja Prunk Zdravković, Bogdan Zdravković, Marko Zdravković, Barbara Dariš, Mojca Lunder, Polonca Ferk
BACKGROUND: Octocrylene (OCT) is one of the most widespread chemical UV filters used in sunscreens and cosmetic products. Despite the use of sunscreens and personal care products over decades, melanoma as the most serious and aggressive form of skin cancer is still a cause of concern. Hence the aim of this study was to investigate any potential influence of OCT on metabolic activity, cytotoxicity and ABCB5 mRNA expression in melanoma cells. The ABCB5 transmembrane protein was tested due to its well-known role in the initiation, invasion and metastatic spread of various cancers, including melanoma...
July 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28699163/conventional-sunscreen-application-does-not-lead-to-sufficient-body-coverage
#8
Z Jovanovic, Th Schornstein, A Sutor, G Neufang, R Hagens
OBJECTIVE: This study aimed to assess sunscreen application habits and relative body coverage after single whole body application. METHODS: Fifty-two healthy volunteers were asked to use the test product once, following their usual sunscreen application routine. Standardized UV photographs (UVP), which were evaluated by Image Analysis (IA), were conducted before and immediately after product application to evaluate relative body coverage. In addition to these procedures, the volunteers completed an online self-assessment questionnaire (SAS) to assess sunscreen usage habits...
July 12, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28697226/randomized-split-face-d%C3%A3-collet%C3%A3-comparative-trial-of-procedure-enhancement-system-for-fractional-non-ablative-laser-resurfacing-treatment
#9
Deanne Mraz Robinson, Ashton P Frulla
<p>INTRODUCTION: A topical proprietary procedural enhancement system (PES) containing a combination of active ingredients including a tripeptide and hexapeptide (TriHex Technology™, Alastin Procedure Enhancement Invasive System, ALASTIN Skincare™, Inc., Carlsbad, CA) has been used successfully to aid in healing and improve symptomatology following resurfacing procedures.</p> <p>METHODS: PES (Gentle Cleanser, Regenerating Skin Nectar with TriHex Technology™, Ultra Nourishing Moisturizer with TriHex Technology™, Soothe + Protect Recovery Balm, Broad Spectrum 30+ Sunscreen) was compared to a basic regimen (Aquaphor™, Cerave™ cleanser, Vanicream™, Alastin Broad Spectrum 30+ Sunscreen) in a split face/ décolleté trial following fractional non-ablative thulium-doped resurfacing treatment to the face or décolleté...
July 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28694170/safety-assessment-and-toxicological-profiling-of-a-novel-combinational-sunprotective-dermal-formulation-containing-melatonin-and-pumpkin-seed-oil
#10
Nilutpal Sharma Bora, Manash Pratim Pathak, Santa Mandal, Bhaskar Mazumder, Rudragoud Policegoudra, Pakalapati Srinivas Raju, Pronobesh Chattopadhyay
Ultraviolet (UV) radiation exposure has been known to cause irreparable damages to human skin. The daunting risk of UV radiation exposure faced by military personnel led to the development of a sunscreen formulation which has superior sun protection factor combined with the ability to counteract reactive oxygen species. The present work deals with the preclinical safety evaluation of the sunscreen formulation comprising of four US FDA approved UV filters; namely avobenzone, octinoxate, oxybenzone, titanium dioxide along with melatonin and pumpkin seed oil, via OECD protocols of assessing acute oral and dermal toxicity; skin sensitizing; skin irritating; ocular irritating and genotoxic potential...
July 8, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28693316/rapid-dissolution-of-zno-nanoparticles-induced-by-biological-buffers-significantly-impacts-cytotoxicity
#11
Josh Eixenberger, Catherine Anders, Rebecca Hermann, Raquel Brown, K M Reddy, Alex Punnoose, Denise Wingett
Zinc oxide nanoparticles (nZnO) are one of the most highly produced nanomaterials and are used in numerous applications including cosmetics and sunscreens despite reports demonstrating their cytotoxicity. Dissolution is viewed as one of the main sources of nanoparticle (NP) toxicity, however dissolution studies can be time-intensive to perform and complicated by issues such as particle separation from solution. Our work attempts to overcome some of these challenges by utilizing new methods using UV/vis and fluorescence spectroscopy to quantitatively assess nZnO dissolution in various biologically relevant solutions...
July 10, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28692926/phototoxic-assessment-of-a-sunscreen-formulation-and-its-excipients-an-in-vivo-and-in-vitro-study
#12
Bryan Hudson Hossy, Alvaro Augusto da Costa Leitão, Elisabete Pereira Dos Santos, Monique Matsuda, Laura Barros Rezende, Janine Simas Cardoso Rurr, Alicia Viviana Pinto, Marcia Ramos-E-Silva, Marcelo de Pádula, Nádia Campos de Oliveira Miguel
BACKGROUND: Cosmetic preservatives are used to protect cosmetic formulations and improve its shelf-life. However, these substances may exert phototoxic effects when used under sunlight. OBJECTIVE: To assess safety, efficacy and putative phototoxic effects of a sunscreen formulation SPF 30 and its excipients. MATERIALS/METHODS: Irradiation was performed with solar simulated light (SSL) and the sunscreen from the School of Pharmacy/UFRJ/Brazil...
June 29, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28690781/bioaccumulation-of-ultraviolet-sunscreen-compounds-mycosporine-like-amino-acids-by-the-heterotrophic-freshwater-ciliate-bursaridium-living-in-alpine-lakes
#13
Bettina Sonntag, Barbara Kammerlander, Monika Summerer
Ciliates in shallow alpine lakes are exposed to high levels of incident solar ultraviolet radiation (UVR). We observed the presence of specific sunscreen compounds, the mycosporine-like amino acids (MAAs), in several populations of Bursaridium, a relatively large ciliate species found in such lakes. The populations from 3 highly UV transparent lakes revealed the presence of 7 MAAs (MG, SH, PR, PI, AS, US, and PE) in total concentrations of 3.6-52.4 10(-5) μg μg(-1) dry weight (DW) per individual, whereas in one glacially turbid and less UV transparent lake, no MAAs were detected in the Bursaridium population...
January 2, 2017: Inland Waters
https://www.readbyqxmd.com/read/28689122/different-sizes-of-zno-diversely-affected-the-cytogenesis-of-the-sea-urchin-paracentrotus-lividus
#14
Maria Oliviero, Simona Schiavo, Gabriella Rametta, Maria Lucia Miglietta, Sonia Manzo
Today nanoparticles (NPs) have many applications in commercial products due to their small size and peculiar properties that, conversely, make them potentially toxic for humans and the environment. ZnO NPs are largely used in many personal care products, such as sunscreens and cosmetics. In this study the cytotoxic effects of ZnO particles with different sizes (ZnO Bulk, >100nm; ZnO NPs, 100nm and ZnO NPs, 14nm) upon the first developmental stages of the sea urchin Paracentrotus lividus, are evaluated. Morphological alterations are also assessed by embryotoxicity tests...
July 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28686768/completeness-of-facial-self-application-of-sunscreen-in-cosmetic-surgery-patients
#15
Nicole A Langelier, Jason Liss, Sandra Stinnett, Julie A Woodward
Previous studies have demonstrated incomplete sunscreen self-application to various facial regions in cosmetic surgery patients, but there is no scientific research on the completeness of facial and periocular sunscreen self-application using ultraviolet (UV) photography for assessment. This prospective, cross-sectional, qualitative study aimed to assess completeness of facial application of sunscreen in oculofacial surgery patients at the Duke Eye Center (Durham, North Carolina). Forty-four participants were enrolled, and completeness of facial sunscreen self-application was assessed using UV photography...
June 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28680948/development-and-evaluation-of-photoprotective-o-w-emulsions-containing-hydroalcoholic-extract-of-neoglaziovia-variegata-bromeliaceae
#16
Raimundo Gonçalves de Oliveira-Júnior, Grasielly Rocha Souza, Christiane Adrielly Alves Ferraz, Ana Paula de Oliveira, Camila de Souza Araújo, Sarah Raquel Gomes de Lima-Saraiva, Silvio Alan Gonçalves Bomfim Reis, Talita Mota Gonçalves, Larissa Araújo Rolim, Pedro José Rolim-Neto, Francine Celise Siqueira César, Jackson Roberto Guedes da Silva Almeida
Neoglaziovia variegata is a Bromeliaceae plant species widely found in Brazil with several pharmacological properties, including photoprotective activity. Although herbal-based active ingredients have been applied in cosmetic products, especially for skin treatment, its application in sunscreen formulations remains unexplored. The aim of this work is to evaluate the photoprotective effect of cosmetic formulations containing hydroalcoholic extract of N. variegata (Nv-HA). Initially, the phenolic and flavonoid total content of Nv-HA were determined...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28670503/aware-motivated-and-striving-for-a-safe-tan-an-exploratory-mixed-method-study-of-sun-protection-during-holidays
#17
Angela M Rodrigues, Falko F Sniehotta, Mark A Birch-Machin, Vera Araujo-Soares
Background: This article presents an exploratory study, aiming to explore the correspondence between knowledge, motivation and sun-protection practices during holidays. Methods: Seventeen participants aged 21-62 years old, recruited from community settings took part in individual face-to-face semi-structured interviews, completed sun sensitivity questions and an objective assessment of sunscreen use. Holidaymakers' knowledge about sun-safe messages, intentions and perceptions of barriers and facilitators for sun-protection were assessed...
2017: Health Psychology and Behavioral Medicine
https://www.readbyqxmd.com/read/28661208/natural-substances-for-prevention-of-skin-photo-ageing-screening-systems-in-the-development-of-sunscreen-and-rejuvenation-cosmetics
#18
Vladimir A Kostyuk, Alla I Potapovich, Ahmed R Albuhaydar, Wolfgang Mayer, Chiara De Luca, Liudmila G Korkina
Solar broad-band UV irradiation is commonly regarded as a major causative reason for cutaneous photo-ageing. The pro-ageing molecular pathways and cellular targets affected by UVA+UVB light in human skin have been extensively investigated. Notwithstanding growing knowledge in mechanisms of photo-ageing, research and development of clinically efficient, non-toxic and sustainable topical preparations providing full physical, chemical, and biological photo-protection still remain a great challenge for pharmaceutical and cosmetic industries...
June 29, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28652793/evaluation-of-a-novel-very-high-sun-protection-factor-moisturizer-in-adults-with-rosacea-prone-sensitive-skin
#19
Mathieu Grivet-Seyve, Francine Santoro, Nadège Lachmann
BACKGROUND/OBJECTIVE: Rosacea-prone sensitive skin requires high sun-protection factor (SPF) moisturizers. This study evaluated Daylong Extreme SPF 50+ lotion, a novel cream containing five ultraviolet filters, two emollients, and three skin conditioners. SUBJECTS AND METHODS: This was an open-label, single-center study. On day 1, before treatment, subjects answered a questionnaire on their skin conditions and sunscreen habits, and both subjects and dermatologist evaluated skin status...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28636687/types-of-shade-vary-in-protection-just-like-sunscreens
#20
Caroline Opene, Mary-Margaret Chren, Eleni Linos
No abstract text is available yet for this article.
June 21, 2017: JAMA Dermatology
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