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https://www.readbyqxmd.com/read/27906534/food-and-drug-administration-review-and-action-on-over-the-counter-time-and-extent-applications-final-rule
#1
(no author information available yet)
The Food and Drug Administration (FDA or Agency) is amending its nonprescription (over-the-counter or OTC) drug regulations. This final rule supplements the time and extent application (TEA) process for OTC drugs by establishing timelines and performance metrics for FDA's review of non-sunscreen TEAs, as required by the Sunscreen Innovation Act (SIA). It also amends the existing TEA process to include filing determination and withdrawal provisions to make the TEA process more efficient.
November 23, 2016: Federal Register
https://www.readbyqxmd.com/read/27904577/comparison-the-effectiveness-of-pyruvic-acid-50-and-salicylic-acid-30-in-the-treatment-of-acne
#2
Fariba Jaffary, Gita Faghihi, Sara Saraeian, Sayed Mohsen Hosseini
BACKGROUND: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles and one of the most common skin diseases. The peeling method has been recently found to be effective for acne treatment. This study aimed to compare the efficacy of pyruvic acid 50% and salicylic acid 30% peeling in the treatment of mild to moderate acne. MATERIALS AND METHODS: In a prospective single-blinded clinical trial, 86 patients with acne were randomly assigned into two groups...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903435/lack-of-effect-of-selected-sunscreens-applied-on-ex-vivo-human-skin-for-5-methyl-aminolevulinic-acid-penetration-and-protoporphyrin-ix-photoactivation
#3
Hanan Osman-Ponchet, Karine Sevin, Alexandre Gaborit, Magali Kouidhi, Johanna Hanaizi, Pierre Comby, Bernard Ruty, Guy Bouvier
BACKGROUND: Photodynamic therapy (PDT) is a successful treatment for non-melanoma skin cancers. Methyl-aminolevulinate (MAL) is metabolized to protoporphyrin IX (PpIX) which accumulates in the skin lesion and which generates a painful photochemical toxic reaction upon red light exposure. PDT using daylight (DL) exposure is now used to reduce pain and subjects are advised to protect the areas with sunscreen. This work investigated the effect of sunscreen on MAL penetration and PpIX photoactivation in ex vivo human skin...
November 26, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27881943/number-and-size-of-acquired-melanocytic-nevi-and-affecting-risk-factors-in-cases-admitted-to-the-dermatology-clinic
#4
Ayşegül Yalçınkaya İyidal, Ülker Gül, Arzu Kılıç
INTRODUCTION: The size and number of acquired melanocytic nevi (AMN) and presence of dysplastic nevi are the leading risk factors that should be recognized in the development of malignant melanoma. AIM: To evaluate AMN and risk factors in the development of AMN in all age groups admitted to a dermatology outpatient clinic. MATERIAL AND METHODS: Four hundred and twelve patients who were admitted to the dermatology outpatient clinic for any dermatological symptom and who accepted to participate in the study were randomly included in the study...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27881112/photoprotective-potential-in-some-medicinal-plants-used-to-treat-skin-diseases-in-sri-lanka
#5
Mayuri Tharanga Napagoda, Benthota Malavi Arachchige Shamila Malkanthi, Subasinghe Appuhamillage Kaumudi Abayawardana, Mohomed Mallique Qader, Lalith Jayasinghe
BACKGROUND: The constant exposure to solar ultraviolet radiation (UV) has a variety of harmful effects on human health. Although synthetic sunscreen products have been introduced as a preventive/therapeutic strategy, with the realization of their adverse side effects, the recent trend is to search for human friendly alternative formulations especially of plant origin. Therefore, the present study focuses on evaluation of photoprotective activity of aqueous extracts (1 mg/ml) of eleven medicinal plants in Sri Lanka that have been widely employed in traditional medicine as treatment options for various skin diseases and to improve the complexion...
November 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27878788/sun-protective-behaviour-and-sunburn-prevalence-in-primary-and-secondary-schoolchildren-in-western-switzerland
#6
Simone Ackermann, Anne Vuadens, Fabio Levi, Jean-Luc Bulliard
AIMS OF THE STUDY: Although solar overexposure during childhood and adolescence increases the risk of melanoma, determinants of sunburn and sun protective behaviours of Swiss children have scarcely been explored. We investigated sunburn occurrence and sun protective behaviours of schoolchildren in western Switzerland, the region with the highest incidence of melanoma in Europe. MATERIAL AND METHODS: Self-reported questionnaires were administered during regular classes to pupils in 5th (primary school, n = 431), 8th and 11th grades (secondary school, n = 837) in the 18 public schools of La Chaux-de-Fonds...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27871215/formulation-characterization-and-in-vitro-ex-vivo-evaluation-of-quercetin-loaded-microemulsion-for-topical-application
#7
Azar Kajbafvala, Alireza Salabat, Anayatollah Salimi
The aim of this study was to develop a new microemulsion formulation for topical application of poorly soluble drug named quercetin. In order to design suitable microemulsion system, the pseudo-ternary phase diagrams of microemulsion systems were constructed at different surfactant/co-surfactant ratios using tween 80 as surfactant, transcutol® P as co-surfactant and oleic acid as oil phase. Some physicochemical properties such as droplet size, density, refractive index, electrical conductivity, pH, surface tension and viscosity of the microemulsion systems were measured at 298...
November 22, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27869214/irradiance-dependent-uvb-photocarcinogenesis
#8
Cheng-Che E Lan, Ching-Shuang Wu, Shu-Mei Huang, Chin-Han Wu, Hsiao-Chi Lai, Yu-Ting Peng, Pao-Sheng Hou, Hui-Jun Yang, Gwo-Shing Chen
Ultraviolet B (UVB) radiation from the sun may lead to photocarcinogenesis of the skin. Sunscreens were used to protect the skin by reducing UVB irradiance, but sunscreen use did not reduce sunburn episodes. It was shown that UVB-induced erythema depends on surface exposure but not irradiance of UVB. We previously showed that irradiance plays a critical role in UVB-induced cell differentiation. This study investigated the impact of irradiance on UVB-induced photocarcinogenesis. For hairless mice receiving equivalent exposure of UVB radiation, the low irradiance (LI) UVB treated mice showed more rapid tumor development, larger tumor burden, and more keratinocytes harboring mutant p53 in the epidermis as compared to their high irradiance (HI) UVB treated counterpart...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27865524/exposure-to-uv-filters-during-summer-and-winter-in-danish-kindergarten-children
#9
Marianna Krause, Anna-Maria Andersson, Niels E Skakkebaek, Hanne Frederiksen
BACKGROUND: Ultra violet (UV) filters with known or suspected endocrine disrupting properties are widely used in sunscreens and other personal care products, clothing, food packaging and many other consumer products. Danish kindergarten children have sunscreens applied daily during summer to prevent skin burns. OBJECTIVES: To estimate the assumed contribution of sunscreens to the total exposure to UV filters, we measured the urinary excretion of UV filters during summer and winter in kindergarten children...
November 16, 2016: Environment International
https://www.readbyqxmd.com/read/27862570/-communication-about-melanoma-and-risk-reduction-after-melanoma-diagnosis
#10
Vivian M Rodríguez, Marianne Berwick, Jennifer L Hay
OBJECTIVE: Melanoma patients are advised to perform regular risk reduction practices including sun protection as well as skin self-examinations (SSE) and physician-led examinations. Melanoma-specific communication regarding family risk and screening may promote such behaviors. To this end, associations between patients' melanoma-specific communication and risk reduction were examined. METHODS: Melanoma patients (N = 169) drawn from a population-based cancer registry reported their current risk reduction practices, perceived risk of future melanoma, and communication with physicians and relatives about melanoma risk and screening...
November 15, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27853004/do-we-really-need-sunscreens
#11
Atul Taneja, Asit Mittal, Ranjana Beniwal
No abstract text is available yet for this article.
November 17, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27847958/photocages-for-protection-and-controlled-release-of-bioactive-compounds
#12
I Aparici-Espert, M C Cuquerella, C Paris, V Lhiaubet-Vallet, M A Miranda
Using a sunscreen-based photocage, we have demonstrated that it is possible to prevent photodegradation of a bioactive compound and to achieve its controlled photorelease. The concept has been proven linking avobenzone, one of the most important UVA blockers, to ketoprofen, which is a representative example of a photosensitive drug.
November 16, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27829807/knowledge-attitudes-and-practices-of-the-general-public-toward-sun-exposure-and-protection-a-national-survey-in-saudi-arabia
#13
Khalid M AlGhamdi, Aeed S AlAklabi, Abdulla Z AlQahtani
Background: Many international studies have been conducted to assess the knowledge, attitudes and practices (KAP) of the public toward sun exposure and sun-protection measures. However, there are scarce data on these factors from the Middle East. Objectives: This study aimed to explore the KAP of the public toward sun exposure and sun-protection measures among Saudis. Methods: A cross-sectional survey using a specially designed questionnaire was conducted on a stratified random sample of the general population in the five geographical regions of Saudi Arabia (central, eastern, northern, southern, and western)...
November 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/27816646/hesperidin-ameliorates-uv-radiation-induced-skin-damage-by-abrogation-of-oxidative-stress-and-inflammatory-in-hacat-cells
#14
Min Li, Xiang-Fei Lin, Jie Lu, Bing-Rong Zhou, Dan Luo
Ultraviolet A (UVA) radiation contributes to skin photoaging. Hesperidin which is a flavanone glycoside found in citrus fruit peels, have been intensively studied for their UVA-protective activity, but its effects and mechanisms on UVA irradiation-induced inflammation and oxidative stress have never been described. Thus, the purpose of this study was to evaluate the effects of hesperidin in skin oxidative stress and inflammation induced by UVA irradiation. In this study, we firstly examined whether hesperidin may exert direct protective effects on the UVA-induced in human keratinocytes (HaCaT) cell injury in vitro...
November 1, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27796700/benzophenone-3-increases-metastasis-potential-in-lung-cancer-cells-via-epithelial-to-mesenchymal-transition
#15
Preeyaporn Plaimee Phiboonchaiyanan, Kesarin Busaranon, Chuanpit Ninsontia, Pithi Chanvorachote
Exposure to compounds with cancer-potentiating effects can contribute to the progression of cancer. Herein we have discovered for the first time that benzophenone-3 (BP-3), a chemical used as sunscreen in various cosmetic products, enhances the ability of lung cancer cells to undergo metastasis. The exposure of the lung cancer cells to BP-3 at non-toxic concentrations significantly increased the number of anoikis resistant cells in a dose-dependent manner. Also, BP-3 increased the growth rate as well as the number of colonies accessed by anchorage-independent growth assay...
October 28, 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/27791379/a-perspective-on-the-ultrafast-photochemistry-of-solution-phase-sunscreen-molecules
#16
Lewis A Baker, Simon E Greenough, Vasilios G Stavros
Sunscreens are the most common way of providing on-demand additional photoprotection to the skin. Ultrafast transient absorption spectroscopy has recently proven to be an invaluable tool in understanding how the components of commercial sunscreen products display efficient photoprotection. Important examples of how this technique has unravelled the photodynamics of common components are given in this perspective and some of the remaining unanswered questions are discussed.
October 28, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27777081/novel-biocomposite-of-carboxymethyl-chitosan-and-pineapple-peel-carboxymethylcellulose-as-sunscreen-carrier
#17
Lucksanee Wongkom, Ampa Jimtaisong
This study aims to prepare of biocomposite of carboxymethyl chitosan (CM-chitosan) and carboxymethylcellulose (CMC) from Ananas comosus (pineapple) peelfor use as broad spectrum sunscreen carrier. Biocomposite was produced by using ferulic acid (FA), a plant extract, as crosslinker with the optimal ratio of CMC: CM-chitosan: FA at 1:2:4%w. FT-IR technique demonstrated that crosslinking may occur at amine group of CM-chitosan and carboxyl group of FA and hydrogen bonding between hydroxyl group of CMC and carboxyl group of FA...
October 21, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27775979/alkyl-glucosides-in-contact-dermatitis-a-systematic-review
#18
Camille Loranger, Maisa Alfalah, Marie-Christine Ferrier Le Bouedec, Denis Sasseville
Ecologically sound because they are synthesized from natural and renewable sources, the mild surfactants alkyl glucosides are being rediscovered by the cosmetic industry. They are currently found in rinse-off products such as shampoos, liquid cleansers, and shower gels, but also in leave-on products that include moisturizers, deodorants, and sunscreens. During the past 15 years, numerous cases of allergic contact dermatitis have been published, mostly to lauryl and decyl glucosides, and these compounds are considered emergent allergens...
October 21, 2016: Dermatitis
https://www.readbyqxmd.com/read/27775973/allergen-of-the-year-alkyl-glucosides
#19
Maisa Alfalah, Camille Loranger, Denis Sasseville
Alkyl glucosides are surfactants synthesized through the condensation of long-chain fatty alcohols and glucose, extracted from vegetal, renewable sources. Although available for more than 4 decades, they have been rediscovered in recent years because of their eco-friendly character. They are used in various leave-on and rinse-off cosmetics and are considered of low irritancy and allergenicity. However, since the early 2000s, cases of allergic contact dermatitis to this family of molecules have been repeatedly reported...
October 21, 2016: Dermatitis
https://www.readbyqxmd.com/read/27770564/lung-inflammation-caused-by-long-term-exposure-to-titanium-dioxide-in-mice-involving-in-nf-%C3%AE%C2%BAb-signalling-pathway
#20
Dong Liu, Jie-Lu Zhou, Fashui Hong, Yu-Qing Zhang
Titanium dioxide nanoparticles (TiO2 NPs) are used in many fields, such as paints, medicine additives, food additives, sunscreens and agriculture. The aim of this study was to investgate the mechanism behind the formation of inflammation induced by TiO2 NPs. ICR mice were exposed to TiO2 NPs through intragastric administration at 2.5, 5 and 10 mg/kg body weight every day for 90 consecutive days. The experiment suggested that long-term exposure to TiO2 NPs resulted in an obvious inflammatory response in mice lung tissues, which led to a thickened alveoli septum, lung hyperaemia, and titanium accumulation...
October 22, 2016: Journal of Biomedical Materials Research. Part A
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