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climacteric syndrome

Yu O Fedotoval, A G Shleikin
This literature review is focused on findings concerning the pharmacological effects of Dioscorea phytosaponins (DPSs) on female organism. Expediency and prospects of developing DPS preparations for the treatment of mnestic and metabolic disorders accompanying climacteric syndrome are assessed.
2016: Eksperimental'naia i Klinicheskaia Farmakologiia
Fang-Ping Chen, Chee Jen Chang, An-Shine Chao, Hong-Yuan Huang, Jian-Pei Huang, Meng-Hsing Wu, Ching-Chou Tsai, Fu-Tsai Kung, Ching-Wen Chang, Yung-Chieh Tsai
OBJECTIVE: To assess the effects of 2 months of treatment with Femarelle for climacteric syndrome in Taiwanese postmenopausal women. MATERIALS AND METHODS: A multi-center, open-label trial of 260 postmenopausal women, age ≥ 45 years with vasomotor symptoms. Women were enrolled after obtaining a detailed medical history and a thorough physical examination. They then received Femarelle (640 mg/d) twice daily for 8 weeks. The primary outcome was the changes in the frequency and severity of hot flushes from baseline to 4 weeks (1 month) and 8 weeks (2 months)...
June 2016: Taiwanese Journal of Obstetrics & Gynecology
Márcia P Jorge, Danilo F Santaella, Isabella M O Pontes, Victor K M Shiramizu, Ezequiel B Nascimento, Alícia Cabral, Telma M A M Lemos, Regina H Silva, Alessandra M Ribeiro
OBJECTIVES: Yoga practice includes a group of specific psychophysical techniques. Although previous studies showed beneficial effects of yoga for health and rehabilitation, improving quality of life, there are few studies on the possible therapeutic application of yoga during the climacteric period. The purpose of this study was to investigate the psychophysiological effects of Hatha Yoga regular practice in post-menopausal women. METHODS: Eighty-eight post-menopausal women volunteered for this 12-week trial...
June 2016: Complementary Therapies in Medicine
Lei Liang, Xu-Hui Zhang, Bo Ji, Hui Yao, Xiao-Mei Ling, Zhi-Jian Guo, Hong-Zhu Deng, Xin-Rong Wu
Yifuning is a traditional Chinese medicine recipe that has been used for many years in China for its effects on treating climacteric syndrome in women. The present study aimed to demonstrate the effects and underlying molecular mechanism of Yifuning on the ovaries of aging rats. Selected aging rats were administered different doses of Yifuning (1.0 or 2.0 g/kg by lavage), and after 6 weeks the rats were sacrificed. The activit of indicators of oxidative stress in the serum were measured. The expression levels of 8-oxo-2'-deoxyguanosine (8-OHDG) and p53 in the ovaries were examined using immunohistochemistry...
July 2016: Molecular Medicine Reports
Ying Zhang, Xudong Zhao, Rainer Leonhart, Maya Nadig, Annette Hasenburg, Michael Wirsching, Kurt Fritzsche
OBJECTIVE: This cross-cultural study aimed to compare climacteric symptoms, self-esteem, and perceived social support between Mosuo and Han Chinese women, and to explore the interaction between culture and climacteric symptoms. Mosuo is a Chinese minority group with a matriarchal structure, and Han Chinese is the majority ethnic group in China with a patriarchal structure. METHODS: Through convenience sampling, 54 Mosuo women and 52 Han Chinese women between 40 and 60 years of age completed the sociodemographic questionnaire, the Menopause Rating Scale, the Self-Esteem Scale, and the Perceived Social Support Scale...
July 2016: Menopause: the Journal of the North American Menopause Society
A Podfigurna-Stopa, A Czyzyk, M Grymowicz, R Smolarczyk, K Katulski, K Czajkowski, B Meczekalski
PURPOSE: Premature ovarian insufficiency (POI) is defined as the cessation of the ovarian function before the age of 40 years. POI aetiology may be related to iatrogenic or endogenous factors and in many cases remains unclear. The aim of this review was to characterize the long-term consequences of POI. METHODS: The available literature regarding the long-term consequences of POI from MEDLINE has been reviewed. RESULTS: Lack of ovarian steroids synthesis has serious consequences for women's health...
September 2016: Journal of Endocrinological Investigation
Sarah Eisenhardt, Johannes Fleckenstein
Climacteric syndrome refers to recurring symptoms such as hot flashes, chills, headache, irritability and depression. This is usually experienced by menopausal women and can be related to a hormonal reorganization in the hypothalamic-pituitary-gonadal axis. In Traditional Chinese Medicine, originating 1000s of years ago, above-mentioned symptoms can be interpreted on the basis of the philosophic diagnostic concepts, such as the imbalance of Yin and Yang, the Zang-Fu and Basic substances (e.g. Qi, Blood and Essence)...
July 2016: Archives of Gynecology and Obstetrics
Grazia Lesi, Giorgia Razzini, Muriel Assunta Musti, Elisa Stivanello, Chiara Petrucci, Benedetta Benedetti, Ermanno Rondini, Maria Bernadette Ligabue, Laura Scaltriti, Alberto Botti, Fabrizio Artioli, Pamela Mancuso, Francesco Cardini, Paolo Pandolfi
PURPOSE: To determine the effectiveness of acupuncture for the management of hot flashes in women with breast cancer. PATIENTS AND METHODS: We conducted a pragmatic, randomized controlled trial comparing acupuncture plus enhanced self-care versus enhanced self-care alone. A total of 190 women with breast cancer were randomly assigned. Random assignment was performed with stratification for hormonal therapy; the allocation ratio was 1:1. Both groups received a booklet with information about climacteric syndrome and its management to be followed for at least 12 weeks...
May 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Ioannis S Minas, Georgia Tanou, Evangelos Karagiannis, Maya Belghazi, Athanassios Molassiotis
Kiwifruit [Actinidia deliciosa (A. Chev.) C.F. Liang et A.R. Ferguson, cv. "Hayward"] is classified as climacteric fruit and the initiation of endogenous ethylene production following harvest is induced by exogenous ethylene or chilling exposure. To understand the biological basis of this "dilemma," kiwifruit ripening responses were characterized at 20°C following treatments with exogenous ethylene (100 μL L(-1), 20°C, 24 h) or/and chilling temperature (0°C, 10 days). All treatments elicited kiwifruit ripening and induced softening and endogenous ethylene biosynthesis, as determined by 1-aminocyclopropane-1-carboxylic acid (ACC) content and ACC synthase (ACS) and ACC oxidase (ACO) enzyme activities after 10 days of ripening at 20°C...
2016: Frontiers in Plant Science
Cássia Raquel Teatin Juliato, Luiz Francisco Baccaro, Adriana Orcesi Pedro, Lucia Costa-Paiva, Jeffrey Lui-Filho, Aarão Mendes Pinto-Neto
AIMS: There are few population-based studies evaluating the epidemiology of overactive bladder syndrome (OAB) in women, especially in the climacteric stage where there is a decrease in estrogen production. This study aimed to assess the prevalence of OAB and associated factors in climacteric Brazilian women. METHODS: A descriptive, exploratory, cross-sectional study was conducted between September 2012 and June 2013 with 749 women (a population-based household survey)...
March 2016: Maturitas
Pluvio J Coronado, Rafael Sánchez-Borrego, Miguel A Ruiz, Laura Baquedano, Sonia Sánchez, Cristina Argudo, Mariela Fernández-Abellán, Silvia González, Eva Iglesias, Jackie Calleja, Jesus Presa, Alfonso Duque, Fernando Ruiz, Borja Otero, Javier Rejas
OBJECTIVE: To analyse the psychometric properties of the Cervantes scale short-form (SF) in the peri- and post-menopausal periods. METHODS: Outpatients women 45-65 years with menstrual problems associated with the climacteric syndrome were analysed. Original and SF versions of the Cervantes scale were administered along with the EuroQol-5D (EQ-5D) and work productivity and activity impairment questionnaire (WPAI) scales. Conceptual model, burden of administration, feasibility, reliability, criteria validity and construct validity were assessed...
February 2016: Maturitas
Cynthia A Stuenkel, Susan R Davis, Anne Gompel, Mary Ann Lumsden, M Hassan Murad, JoAnn V Pinkerton, Richard J Santen
OBJECTIVE: The objective of this document is to generate a practice guideline for the management and treatment of symptoms of the menopause. PARTICIPANTS: The Treatment of Symptoms of the Menopause Task Force included six experts, a methodologist, and a medical writer, all appointed by The Endocrine Society. EVIDENCE: The Task Force developed this evidenced-based guideline using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe the strength of recommendations and the quality of evidence...
November 2015: Journal of Clinical Endocrinology and Metabolism
Krzysztof Krysta, Sławomir Murawiec, Anna Warchala, Karolina Zawada, Wiesław J Cubała, Mariusz S Wiglusz, Katarzyna Jakuszkowiak-Wojten, Marek Krzystanek, Irena Krupka-Matuszczyk
Opipramol is considered as a pharmacological agent that does not fit the classification taking into account the division of antidepressants, antipsychotics and anxiolytics. It has a structure related to tricyclic antidepressants but it has a different mechanism of action, i.e. binding to sigma1 and to sigma2 sites. It has been regarded as an effective drug in general anxiety disorders together with other agents like SSRI`s, SNRI`s, buspirone and pregabalin for many years. It can however also be indicated in other conditions, e...
September 2015: Psychiatria Danubina
Grzegorz Jakiel, Marta Makara-Studzińska, Michał Ciebiera, Aneta Słabuszewska-Jóźwiak
The term 'male menopause' was first used in 1944 to describe various complaints of ageing men which at least partially mirrored the climacteric symptoms in women. Continuous research resulted in the evolution of opinions about the nature of these complaints, from the clinical syndrome, diagnosed with the use of disease-targeted questionnaires, to a well-defined clinical and biochemical syndrome. The pathophysiological causes - gonad ageing (with a compensatory rise in luteinizing hormone), age-related increase in serum sex hormone-binding globulin (SHBG) levels, the role of visceral adipose tissue as a place for aromatization of androgen to estrogen, and lower sensitivity of testosterone receptors - have been described...
March 2015: Przeglad Menopauzalny, Menopause Review
Georgia Tanou, Ioannis S Minas, Evangelos Karagiannis, Daniela Tsikou, Stéphane Audebert, Kalliope K Papadopoulou, Athanassios Molassiotis
BACKGROUND AND AIMS: Despite their importance in many aspects of plant physiology, information about the function of oxidative and, particularly, of nitrosative signalling in fruit biology is limited. This study examined the possible implications of O3 and sodium nitroprusside (SNP) in kiwifruit ripening, and their interacting effects. It also aimed to investigate changes in the kiwifruit proteome in response to SNP and O3 treatments, together with selected transcript analysis, as a way to enhance our understanding of the fruit ripening syndrome...
September 2015: Annals of Botany
G Allais, G Chiarle, F Bergandi, C Benedetto
Hormonal changes during the reproductive cycle are thought to account for the variation in migraine occurrence and intensity. Although the majority of women and the specialists treating them do not consider migraine as a component of the climacteric syndrome, many women, in fact, do experience migraine during perimenopause. If a woman already suffers from migraine, the attacks often worsen during menopausal transition. Initial onset of the condition during this period is relatively rare. Women with the premenstrual syndrome (PMS) prior to entering menopause are more likely to experience, during late menopausal transition, an increased prevalence of migraine attacks...
May 2015: Neurological Sciences
Latiffah Abdul Latiff, Saadat Parhizkar, Mohammad Aziz Dollah, Syed Tajuddin Syed Hassan
OBJECTIVES: The aim of this open label crossover study was to investigate the effects of Nigella sativa on reproductive health and metabolic profile of perimenopausal women in Rawang, Malaysia. MATERIALS AND METHODS: Sixty nine perimenopausal women aged 45 to 65 were allocated into the experimental group treated orally with 1600mg/day of encapsulated pure powdered N. sativa compared to control groups treated with placebo for 12 weeks. At the end of study, participants underwent washout period for fourteen days before being crossed over and continued for another cycle of treatment...
December 2014: Iranian Journal of Basic Medical Sciences
Erika Borkoles, Nick Reynolds, David R Thompson, Chantal F Ski, Lily Stojanovska, Remco C J Polman
OBJECTIVES: There is evidence that menopausal symptoms manifested at peri-menopause occur less frequently when compared to the symptoms experienced at post-menopause. The aim of this study was to investigate this and to test the hypothesis that depressive symptomatology mediates the relationship between menopausal stage and symptom frequency. METHODS: This cross-sectional study included 213 women (M age=52 years), of whom 125 were peri- and 88 post-menopausal. Measures comprised the Center for Epidemiologic Studies-Depression scale (CES-D) and the Women's Health Questionnaire (WHQ) vasomotor symptoms and somatic symptoms subscales...
June 2015: Maturitas
Alberto Alvarado-García, Tomás Hernández-Quijano, Marcelino Hernández-Valencia, Miriam Concepción Negrín-Pérez, Brendha Ríos-Castillo, Gregorio Urbano Valencia-Pérez, Víctor Saúl Vital-Reyes, María Antonia Basavilvazo-Rodríguez, Laura Pilar Torres-Arreola, Guillermo Federico Ortiz-Luna, Fernando Sánchez-Aguirre, Armando Montaño-Uscanga
Post-menopause is the period of life where a deep decline occurs in circulating estrogen levels, inducing the appearance of psycho and somatic symptoms. The classification to understand the chronology of reproductive aging in women (known as STRAW) determines the clinical and endocrine changes contemplating menstrual cycles, symptoms, measurements of FSH, LH, inhibin B, anti-Mullerian hormone , and follicular account. The diagnosis of menopause is established by the absence of menstruation for 12 months or more...
March 2015: Revista Médica del Instituto Mexicano del Seguro Social
Soo-Jin Jeong, Hye-Sun Lim, Chang-Seob Seo, Seong-Eun Jin, Sae-Rom Yoo, Nari Lee, Hyeun-Kyoo Shin
Gyejibokryeong-hwan (GJBRH; Keishi-bukuryo-gan in Japan and Guizhi Fuling Wan in China) is a traditional herbal formula comprising five medicinal herbs and is used to treat climacteric syndrome. GJBRH has been shown to exhibit biological activity against diabetes, diabetic nephropathy, atherosclerosis, ischemia, and cancer. However, there is no scientific evidence of its activities against skin inflammation, including atopic dermatitis. We used the HaCaT human keratinocyte cell line to investigate the effects of GJBRH on skin inflammation...
2015: Biological & Pharmaceutical Bulletin
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