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https://www.readbyqxmd.com/read/29792780/cardiovascular-screening-practices-and-attitudes-from-the-ncaa-autonomous-power-5-conferences
#1
Christopher W Miars, Andreas Stamatis, Grant B Morgan, Jonathan A Drezner
BACKGROUND: The development of athlete-specific electrocardiogram (ECG) interpretation standards, along with recent rates of sudden cardiac death (SCD) in athletes being higher than previously estimated, has heightened the debate in the sports medicine community regarding cardiovascular screening of the college athlete, including whether certain high-risk subsets, such as male basketball athletes, should undergo more intensive screening. HYPOTHESIS: ECG and/or echocardiography screening in National Collegiate Athletic Association Autonomous 5 Division I (A5DI) schools will be more common than previous reports, and there will be more frequent use of noninvasive cardiac screening for men's basketball players than the general athlete population...
May 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29792764/use-of-a-depression-and-sleep-impairment-treatment-guideline-to-improve-quality-of-life-for-patients-with-sickle-cell-disease
#2
Sheran M Simo, Debra Siela
BACKGROUND: Pain in sickle cell disease (SCD) is often joined by other affective disorders such as depression and/or sleep impairment that can impact pain levels and quality of life (QoL). AIM: To develop a guideline to improve the process of assessment and treatment of depression and sleep impairment in patients admitted with SCD. METHOD: An interdisciplinary team used the Stetler model to create the Guideline for the Evaluation and Treatment of Depression and Sleep Impairment in Sickle Cell Disease...
May 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29792312/identification-of-patients-with-hemoglobin-ss-s%C3%AE-0-thalassemia-disease-and-pain-crises-within-electronic-health-records
#3
Ashima Singh, Javier Mora, Julie A Panepinto
Electronic health records (EHRs) are a source of big data that provide opportunities for conducting population-based studies and creating learning health systems, especially for rare conditions such as sickle cell disease (SCD). The objective of our study is to validate algorithms for accurate identification of patients with hemoglobin (Hb) SS/Sβ0 thalassemia and acute care encounters for pain among SCD patients within EHR warehouse. We used data for children receiving care at Children's Hospital of Wisconsin from 2013 to 2016 to test the accuracy of the 2 algorithms...
June 12, 2018: Blood Advances
https://www.readbyqxmd.com/read/29792205/distinct-correlations-between-lipogenic-gene-expression-and-fatty-acid-composition-of-subcutaneous-fat-among-cattle-breeds
#4
David Gamarra, Noelia Aldai, Aisaku Arakawa, Luis Javier R Barron, Andrés López-Oceja, Marian M de Pancorbo, Masaaki Taniguchi
BACKGROUND: The fatty acid (FA) composition of adipose tissue influences the nutritional quality of meat products. The unsaturation level of FAs is determined by fatty acid desaturases such as stearoyl-CoA desaturases (SCDs), which are under control of the transcription factor sterol regulatory element-binding protein (SREBP). Differences in SCD genotype may thus confer variations in lipid metabolism and FA content among cattle breeds. This study investigated correlations between FA composition and lipogenic gene expression levels in the subcutaneous adipose tissue of beef cattle breeds of different gender from the Basque region of northern Spain...
May 23, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29791238/low-dose-ketamine-infusion-for-adjunct-management-during-vaso-occlusive-episodes-in-adults-with-sickle-cell-disease-a-case-series
#5
Nicole Palm, Catherine Floroff, Tanna B Hassig, Alice Boylan, Julie Kanter
The optimal management of recurrent painful episodes in individuals living with sickle cell disease (SCD) remains unclear. Currently, the primary treatment for these episodes remains supportive, using fluids and intravenous opioid and anti-inflammatory medications. Few reports have described the use of adjunct subanesthetic doses of ketamine to opioids for treatment of refractory pain in SCD. This article reports a retrospective case series of five patients admitted to the intensive care unit (ICU) with prolonged vaso-occlusive episodes (VOEs)...
May 23, 2018: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/29788942/use-of-autologous-bone-marrow-stem-cell-implantation-for-osteonecrosis-of-the-knee-in-sickle-cell-disease-a-preliminary-report
#6
Gildasio Daltro, Bruno Adelmo Franco, Thiago Batista Faleiro, Davi Araujo Veiga Rosário, Paula Braga Daltro, Roberto Meyer, Vitor Fortuna
BACKGROUND: The purpose of our study was to evaluate safety, feasibility and clinical results of bone marrow mononuclear cell (BMC) implantation for early-stage osteonecrosis of the knee (OK) secondary to sickle cell disease. METHODS: Thirty-three SCD patients (45 knees) with OK treated with BMC implantation in the osteonecrotic lesion were clinically and functionally evaluated through the American Knee Society Clinical Score (KSS), Knee Functional Score (KFS) and Numeric Rating Scale (NRS) pain score...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788439/repair-of-temporal-bone-defects-via-the-middle-cranial-fossa-approach-treatment-of-2-pathologies-with-1-operation
#7
Daniel B Eddelman, Stephan Munich, Ryan B Kochanski, Michael Eggerstedt, Robert P Kazan, Roham Moftakhar, Lorenzo Munoz, Rich W Byrne, R Mark Wiet
BACKGROUND: Temporal bone dehiscence (TBD) often results in leakage of cerebrospinal fluid (CSF) and/or encephalocele. TBD can also occur over the superior semicircular canal, causing debilitating vertigo. Both can be repaired surgically, but traditional treatment is focused only on one pathology, not both. OBJECTIVE: To report our experience in the treatment of TBD via the middle cranial fossa (MCF) approach. METHODS: A retrospective review was conducted for all patients who underwent MCF approach for surgical repair of any temporal fossa dehiscence...
May 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29785408/stroke-prevalence-in-children-with-sickle-cell-disease-in-sub-saharan-africa-a-systematic-review-and-meta-analysis
#8
Lianna J Marks, Deogratias Munube, Philip Kasirye, Ezekiel Mupere, Zhezhen Jin, Philip LaRussa, Richard Idro, Nancy S Green
Objectives . The prevalence of stroke among children with sickle cell disease (SCD) in sub-Saharan Africa was systematically reviewed. Methods . Comprehensive searches of PubMed, Embase, and Web of Science were performed for articles published between 1980 and 2016 (English or French) reporting stroke prevalence. Using preselected inclusion criteria, titles and abstracts were screened and full-text articles were reviewed. Results . Ten full-text articles met selection criteria. Cross-sectional clinic-based data reported 2...
2018: Global Pediatric Health
https://www.readbyqxmd.com/read/29785063/the-comprehension-problems-of-children-with-poor-reading-comprehension-despite-adequate-decoding-a-meta-analysis
#9
Mercedes Spencer, Richard K Wagner
The purpose of this meta-analysis was to examine the comprehension problems of children who have a specific reading comprehension deficit (SCD), which is characterized by poor reading comprehension despite adequate decoding. The meta-analysis included 86 studies of children with SCD who were assessed in reading comprehension and oral language (vocabulary, listening comprehension, storytelling ability, and semantic and syntactic knowledge). Results indicated that children with SCD had deficits in oral language ( d = -0...
June 2018: Review of Educational Research
https://www.readbyqxmd.com/read/29784054/systematic-literature-review-and-assessment-of-patient-reported-outcome-instruments-in-sickle-cell-disease
#10
Grammati Sarri, Menaka Bhor, Seye Abogunrin, Caroline Farmer, Savita Nandal, Rashid Halloway, Dennis A Revicki
BACKGROUND: Sickle cell disease (SCD) is a chronic condition associated with high mortality and morbidity. It is characterized by acute clinical symptoms such as painful vaso-occlusive crises, which can impair health-related quality of life (HRQL). This study was conducted to identify validated patient-reported outcome (PRO) instruments for use in future trials of potential treatments for SCD. METHODS: A systematic literature review (SLR) was performed using MEDLINE and EMBASE to identify United States (US)-based studies published in English between 1997 and 2017 that reported on validated PRO instruments used in randomized controlled trials and real-world settings...
May 21, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29782639/sudden-cardiac-death-in-athletes-and-the-value-of-cardiovascular-magnetic-resonance
#11
REVIEW
Sophie I Mavrogeni, Flora Bacopoulou, Despoina Apostolaki, George P Chrousos
Sudden cardiac death (SCD) is the non-traumatic death, due to loss of heart function that occurs suddenly and unexpectedly within 6 hours of a previously normal state of health. It is related to intense competitive sports promoting ventricular tachycardia (VT)/ventricular fibrillation (VF) in the presence of underlying abnormal substrate. A serial evaluation of cardiac physiologic changes taking place during training will allow the better understanding of athlete's heart and will facilitate its discrimination from other gray-zone cardiomyopathies...
May 21, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29782316/from-subjective-cognitive-decline-to-alzheimer-s-disease-the-predictive-role-of-neuropsychological-assessment-personality-traits-and-cognitive-reserve-a-7-year-follow-up-study
#12
Valentina Bessi, Salvatore Mazzeo, Sonia Padiglioni, Carolina Piccini, Benedetta Nacmias, Sandro Sorbi, Laura Bracco
The aim of this study was to evaluate the accuracy of neuropsychological assessment in predicting conversion from subjective cognitive decline (SCD) and mild cognitive impairment (MCI) to Alzheimer's disease (AD) and the effect of personality traits and cognitive reserve in progression from SCD to MCI. As part of a longitudinal, clinical-neuropsychological-genetic survey on SCD and MCI, 284 patients referred to our hospital between 1990 and 2017 were included. All patients underwent clinical-extensive neuropsychological evaluation and Apolipoprotein E genotyping; personality traits were assessed in a subgroup...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29781571/new-approach-to-accurate-interpretation-of-sickle-cell-disease-newborn-screening-by-applying-multiple-of-median-cutoffs-and-ratios
#13
Bichr Allaf, Franck Patin, Jacques Elion, Nathalie Couque
BACKGROUND: The main goal of newborn screening (NBS) for sickle cell disease (SCD) is to detect affected neonates so that specific preventive care can be implemented. High-performance liquid chromatography (HPLC) used for NBS has high sensitivity and specificity, but we lack guidelines for quantitative hemoglobin (Hb) fraction interpretation. The purpose of this study was to determine cutoff values to standardize quantitative interpretation in SCD NBS for different clinical situation such as, red blood cell transfusion or beta-thalassemia, which can be real screening pitfalls...
May 21, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29780860/microbleeds-are-associated-with-depressive-symptoms-in-alzheimer-s-disease
#14
Anna E Leeuwis, Niels D Prins, Astrid M Hooghiemstra, Marije R Benedictus, Philip Scheltens, Frederik Barkhof, Wiesje M van der Flier
Introduction: Co-occurrence of cerebrovascular disease and depression led to the "vascular depression hypothesis". White matter hyperintensities (WMHs) have been associated with depressive symptoms in population-based studies. We studied the association between small vessel disease and depressive symptoms in a memory clinic population. Methods: We included >2000 patients with subjective cognitive decline (SCD), mild cognitive impairment, and Alzheimer's disease (AD)...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29780643/late-diagnosis-of-anomalous-aortic-origin-of-a-coronary-artery-from-the-inappropriate-sinus-of-valsalva-during-investigation-of-chest-pain
#15
Brunna Priscylla Américo Carvalho, Marcio Antônio Dos Santos, Wilson Pedro Guimarães Neto, Júlio César Queiroz De França, Márcio Rogério de Souza Braite, Rodrigo Bottura De Araújo, Isabella Gomes Carvalho, Moacir Fernandes de Godoy
In this work are reported two cases of anomalous aortic origin of a coronary artery (AAOCA), with the left main coronary artery (LMCA) arising at the right sinus of Valsalva in a 77-year-old woman and in a 79-year-old man submitted to angiography after positive ischemic tests. The origin of the LMCA or the left descendant artery (LDA) from the right sinus of Valsalva has a prevalence of 0.2%, the origin of the circumflex artery (CXA) from the right sinus 0.5%, and the origin of the right coronary artery (RCA) from the left sinus of Valsalva has a prevalence of 0...
2018: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29779138/cognitive-syndromes-after-the-first-stroke
#16
Denisa Salihović, Dževdet Smajlović, Milija Mijajlović, Emina Zoletić, Omer Ć Ibrahimagić
AIM: The aim of this study is to determine impairments of certain cognitive functions in certain vascular cognitive syndromes and to identify predictors of dementia. PATIENTS AND METHODS: One-year prospective study included 275 patients, who were hospitalized at the Department of Neurology Tuzla and therefore fulfilled certain criteria. Patients were divided into following subgroups of vascular cognitive impairment (VCI): dementia of strategic infarct (DSI), cortical dementia (CD), sub cortical dementia (SCD), hemorrhagic dementia (HD), and patients without dementia...
May 19, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29776555/sudden-coronary-death-in-the-young-evidence-of-contractile-phenotype-of-smooth-muscle-cells-in-the-culprit-atherosclerotic-plaque
#17
Stefania Rizzo, Matteo Coen, Antonija Sakic, Monica De Gaspari, Gaetano Thiene, Giulio Gabbiani, Cristina Basso, Marie-Luce Bochaton-Piallat
BACKGROUND: Culprit coronary atherosclerotic plaques (APs) from young sudden cardiac death (SCD) victims are mostly non-atheromatous, i.e., consisting of proliferative smooth muscle cells (SMCs). Coronary vasospasm has been advocated to explain plaque instability in the absence of thrombosis. Our aim was to characterize the SMC phenotype in the intima and media of coronary arteries from young SCD victims. METHODS AND RESULTS: A total of 38 coronary artery segments were studied: (a) 18 APs from young (≤40 years old) SCD patients, (b) 9 APs from old (>40 years old) SCD patients, (c) 11 non-atherosclerotic coronary arteries from young patients (≤40 years old)...
August 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29773954/pain-catastrophizing-is-associated-with-poorer-health-related-quality-of-life-in-pediatric-patients-with-sickle-cell-disease
#18
Nitya Bakshi, Ines Lukombo, Inna Belfer, Lakshmanan Krishnamurti
Background: Sickle cell disease (SCD) is an inherited disorder of the red blood cells and is associated with chronic multisystem involvement. While SCD has been associated with poorer health-related quality of life (HRQoL), there is a paucity of data on the relationship of psychological covariates other than anxiety and depression and quality of life (QoL) in children with SCD. Materials and methods: We performed a cross-sectional study of psychological factors, HRQoL, and pain-related outcomes in participants with SCD and race-matched controls as part of a larger study of experimental pain phenotyping...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29769224/right-ventricular-dysfunction-and-long-term-risk-of-sudden-cardiac-death-in-patients-with-and-without-severe-left-ventricular-dysfunction
#19
Niyada Naksuk, Nicholas Tan, Deepak Padmanabhan, Krishna Kancharla, Nayani Makkar, Vidhushei Yogeswaran, Prakriti Gaba, Pranita Kaginele, David C Riley, Alan M Sugrue, Andrew N Rosenbaum, Majd A El-Harasis, Samuel J Asirvatham, Suraj Kapa, Christopher J McLeod
BACKGROUND: Right ventricular systolic dysfunction (RVD) often coexists with various cardiopulmonary diseases. However, the association between RVD and risk of sudden cardiac death (SCD) has not been well studied. This study examined the risk of SCD associated with RVD in patients with heterogeneous underlying cardiac diseases. METHODS: The Mayo Clinic cardiac care unit database included 5463 consecutive patients with complete echocardiographic evaluation to assess right ventricular systolic function and RVD severity...
June 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29768104/knowledge-beliefs-attitudes-and-behaviors-regarding-sickle-cell-disease-implications-for-prevention
#20
Marcella Smith, Gracie Brownell
Sickle cell disease (SCD) is a widespread inherited blood disorder, which leaves lasting effects on the health, social functioning, and finances of individuals, families, communities, and health care systems. A nonexperimental, cross-sectional research design was used to assess 415 college students' knowledge about SCD. Data was obtained through an online survey derived from a modified version of the SCD Knowledge Assessment Tool. The majority of participants (79%) reported previous SCD knowledge; however, 21% of the participants reported no previous SCD knowledge...
May 16, 2018: Social Work in Public Health
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