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https://www.readbyqxmd.com/read/28917655/inactivation-of-tnf-lt-locus-alters-mouse-metabolic-response-to-concentrated-ambient-pm2-5
#1
Ziying Hu, Minjie Chen, Huifen Zhou, Anui Tharakan, Xiaoke Wang, Lianglin Qiu, Shuai Liang, Xiaobo Qin, Yuhao Zhang, Wanjun Wang, Yanyi Xu, Zhekang Ying
BACKGROUND: Exposure to ambient fine particulate matter (PM2.5) is associated with increased cardiometabolic morbidity and mortality. This is widely believed to be attributable to PM2.5 exposure-induced pulmonary and subsequent systemic inflammation. Tumor necrosis factor alpha (TNFα), lymphotoxin α (LTα), and lymphotoxin β (LTβ) are three homologous pro-inflammatory cytokines, each with both unique and redundant activities in inflammation. Their role in PM2.5 exposure-induced inflammation and adverse cardiometabolic effects has to be determined...
September 13, 2017: Toxicology
https://www.readbyqxmd.com/read/28916721/loss-of-cardiac-carnitine-palmitoyltransferase-2-results-in-rapamycin-resistant-acetylation-independent-hypertrophy
#2
Andrea S Pereyra, Like Y Hasek, Kate L Harris, Alycia G Berman, Frederick W Damen, Craig J Goergen, Jessica M Ellis
Cardiac hypertrophy is closely linked to impaired fatty acid oxidation, but the molecular basis of this link is unclear. Here, we investigated the loss of an obligate enzyme in mitochondrial long-chain fatty acid oxidation, carnitine palmitoyltransferase 2 (CPT2), on muscle and heart structure, function, and molecular signatures in a muscle- and heart-specific CPT2-deficient mouse (Cpt2M-/-) model. CPT2 loss in heart and muscle reduced complete oxidation of long-chain fatty acids by 87% and 69%, respectively, without altering body weight, energy expenditure, respiratory quotient, or adiposity...
September 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28914786/baseline-and-estimated-trends-of-sodium-availability-and-food-sources-in-the-costa-rican-population-during-2004-2005-and-2012-2013
#3
Adriana Blanco-Metzler, Rafael Moreira Claro, Katrina Heredia-Blonval, Ivannia Caravaca Rodríguez, María de Los A Montero-Campos, Branka Legetic, Mary R L'Abbe
In 2012, Costa Rica launched a program to reduce salt and sodium consumption to prevent cardiovascular disease and associated risk factors, but little was known about the level of sodium consumption or its sources. Our aim was to estimate the magnitude and time trends of sodium consumption (based on food and beverage acquisitions) in Costa Rica. Data from the National Household Income and Expenditure Surveys carried out in 2004-2005 (n = 4231) and 2012-2013 (n = 5705) were used. Records of food purchases for household consumption were converted into sodium and energy using food composition tables...
September 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28914527/locally-induced-adipose-tissue-browning-by-microneedle-patch-for-obesity-treatment
#4
Yuqi Zhang, Qiongming Liu, Jicheng Yu, Shuangjiang Yu, Jinqiang Wang, Li Qiang, Zhen Gu
Obesity is one of the most serious public health problems in the 21st century that may lead to many comorbidities such as type-2 diabetes, cardiovascular diseases, and cancer. Current treatments toward obesity including diet, physical exercise, pharmacological therapy, as well as surgeries are always associated with low effectiveness or undesired systematical side effects. In order to enhance treatment efficiency with minimized side effects, we developed a transcutaneous browning agent patch to locally induce adipose tissue transformation...
September 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28912804/assessment-of-nutritional-status-digestion-and-absorption-and-quality-of-life-in-patients-with-locally-advanced-pancreatic-cancer
#5
J E Witvliet-van Nierop, C M Lochtenberg-Potjes, N J Wierdsma, H J Scheffer, G Kazemier, K Ottens-Oussoren, M R Meijerink, M A E de van der Schueren
BACKGROUND AND AIM: To provide a comprehensive quantitative assessment of nutritional status, digestion and absorption, and quality of life (QoL) in patients with locally advanced pancreatic cancer (LAPC). METHODS: Sixteen patients with LAPC were prospectively assessed for weight loss (WL), body mass index (BMI), fat-free mass index (FFMI), handgrip strength (HGS), dietary macronutrient intake, serum vitamin levels, resting and total energy expenditure (REE and TEE, indirect calorimetry), intestinal absorption capacity and fecal losses (bomb calorimetry), exocrine pancreatic function (fecal elastase-1 (FE1)), and gastrointestinal quality of life (GIQLI)...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28912148/thermal-imaging-is-a-non-invasive-alternative-to-pet-ct-for-measurement-of-brown-adipose-tissue-activity-in-humans
#6
James Matthew Law, David Edward Morris, Chioma Izzi Engbeaya, Victoria Salem, Christopher Coello, Lindsay Robinson, Maduka Jayasinghe, Rebecca Scott, Roger Gunn, Eugenii Rabiner, Tricia Tan, Waljit Dhillo, Stephen Bloom, Helen Budge, Michael Symonds
Background: Obesity and its metabolic consequences are a major cause of morbidity and mortality. Brown adipose tissue (BAT) utilises glucose and free fatty acids to produce heat, thereby increasing energy expenditure. Effective evaluation of human BAT stimulators is constrained by current standard BAT assessment methods as positron emission tomography-computed tomography (PET-CT) requires exposure to high doses of ionising radiation. Infrared thermography (IRT) is a potential non-invasive, safe alternative, although direct corroboration with PET-CT has not previously been established...
September 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28911527/cellular-models-for-the-evaluation-of-the-antiobesity-effect-of-selected-phytochemicals-from%C3%A2-food-and-herbs
#7
REVIEW
Yen-Chen Tung, Pei-Hsuan Hsieh, Min-Hsiung Pan, Chi-Tang Ho
Dietary phytochemicals from food and herbs have been studied for their health benefits for a long time. The incidence of obesity has seen an incredible increase worldwide. Although dieting, along with increased physical activity, seems an easy method in theory to manage obesity, it is hard to apply in real life. Obesity treatment drugs and surgery are not successful or targeted for everyone and can have significant side effects. This low rate of success is the major reason that the overweight as well as the pharmaceutical industry seek alternative methods, including phytochemicals...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28910538/muscular-contraction-frequency-does-not-affect-plasma-homocysteine-concentration-in-response-to-energy-expenditure-and-intensity-matched-acute-exercise-in-sedentary-males
#8
Natalia Úbeda, Brian P Carson, Ángela García-González, Antonio Aguilar-Ros, Ángel Enrique Díaz-Martínez, Rafael Venta, Nicolás Terrados, Donal J O Gorman, Eduardo Iglesias-Gutiérrez
Acute exercise seems to increase total plasma homocysteine (tHcy). That is related to cardiovascular risk, therefore it is important to understand the determinants of its response to all types of exercise. The aim of this study was to examine the impact of cycling at two different rates of muscle contraction on the complete tHcy kinetics. Eight young sedentary males were required to complete two isocaloric (400 kcal) acute exercise trials at 50% VO2peak on separate occasions at 50 or 80 revolutions per minute (rpm)...
September 14, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28903047/caloric-restriction-promotes-structural-and-metabolic-changes-in-the-skin
#9
Maria Fernanda Forni, Julia Peloggia, Tárcio T Braga, Jesús Eduardo Ortega Chinchilla, Jorge Shinohara, Carlos Arturo Navas, Niels Olsen Saraiva Camara, Alicia J Kowaltowski
Caloric restriction (CR) is the most effective intervention known to enhance lifespan, but its effect on the skin is poorly understood. Here, we show that CR mice display fur coat remodeling associated with an expansion of the hair follicle stem cell (HFSC) pool. We also find that the dermal adipocyte depot (dWAT) is underdeveloped in CR animals. The dermal/vennule annulus vasculature is enlarged, and a vascular endothelial growth factor (VEGF) switch and metabolic reprogramming in both the dermis and the epidermis are observed...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28901468/apolipoprotein-a5-regulates-intracellular-triglyceride-metabolism-in-adipocytes
#10
Xiao-Yan Zheng, Bi-Lian Yu, Yu-Fei Xie, Shui-Ping Zhao, Chen-Lu Wu
It has previously been demonstrated that apolipoprotein A5 (apoA5) can be internalized by human adipocytes and significantly decreases intracellular triglyceride content. In the present study, endocytosis of apoA5 by adipocytes under different conditions, and the underlying mechanism by which apoA5 regulates cellular triglyceride storage, was investigated. The results revealed that the apoA5 protein was detected in human subcutaneous abdominal adipose tissues. In addition, the uptake of apoA5 was attenuated in human obese adipose tissues and in cultured adipocytes with hypertrophy or insulin resistance...
September 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28899914/military-training-elicits-marked-increases-in-plasma-metabolomic-signatures-of-energy-metabolism-lipolysis-fatty-acid-oxidation-and-ketogenesis
#11
J Philip Karl, Lee M Margolis, Nancy E Murphy, Christopher T Carrigan, John W Castellani, Elisabeth H Madslien, Hilde-Kristin Teien, Svein Martini, Scott J Montain, Stefan M Pasiakos
Military training studies provide unique insight into metabolic responses to extreme physiologic stress induced by multiple stressor environments, and the impacts of nutrition in mediating these responses. Advances in metabolomics have provided new approaches for extending current understanding of factors modulating dynamic metabolic responses in these environments. In this study, whole-body metabolic responses to strenuous military training were explored in relation to energy balance and macronutrient intake by performing nontargeted global metabolite profiling on plasma collected from 25 male soldiers before and after completing a 4-day, 51-km cross-country ski march that produced high total daily energy expenditures (25...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28898979/obesity-pathogenesis-an-endocrine-society-scientific-statement
#12
Michael W Schwartz, Randy J Seeley, Lori M Zeltser, Adam Drewnowski, Eric Ravussin, Leanne M Redman, Rudolph L Leibel
Obesity is among the most common and costly chronic disorders worldwide. Estimates suggest that in the United States obesity affects one-third of adults, accounts for up to one-third of total mortality, is concentrated among lower income groups, and increasingly affects children as well as adults. A lack of effective options for long-term weight reduction magnifies the enormity of this problem; individuals who successfully complete behavioral and dietary weight-loss programs eventually regain most of the lost weight...
August 1, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28895643/thyroid-hormone-induced-expression-of-the-hepatic-scaffold-proteins-sestrin2-%C3%AE-klotho-and-frs2%C3%AE-in-relation-to-fgf21-ampk-signaling
#13
Luis A Videla, Romina Vargas, Barbara Riquelme, Javier Fernández, Virginia Fernández
Thyroid hormone (3,3',5-triiodothyronine, T3) accelerates energy metabolism in the liver through mechanisms involving upregulation of AMP-activated protein kinase (AMPK). This study aims to assess the influence of T3 on the expression of the scaffold proteins β-Klotho, fibroblast growth factor receptor substrate 2α (FRS2α), and Sestrin2 in relation to FGF21-AMPK signaling. Male Sprague-Dawley rats were given 0.1 mg T3/kg or hormone vehicle (controls) and studies were done 24 h after treatment. These include measurements of the mRNA expression (qPCR) of hepatic β-Klotho, FGF21, FGF21 receptor-1 (FGFR1), extracellular-signal-regulated kinase 1/2 (ERK1/2), FRS2α, ribosomal S6 kinase-1 (RSK1), liver kinase B1 (LKB1), AMPK, and Sestrin2...
September 11, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28894645/re-examination-of-the-contribution-of-substrates-to-energy-expenditure-during-high-intensity-intermittent-exercise-in-endurance-athletes
#14
Zübeyde Aslankeser, Şükrü Serdar Balcı
BACKGROUND: It has been believed that the contribution of fat oxidation to total energy expenditure is becoming negligible at higher exercise intensities (about 85% VO2max). The aim of the present study was to examine the changes in substrate oxidation during high-intensity interval exercise in young adult men. METHODS: A total of 18 healthy well-trained (aged 19.60 ± 0.54 years, BMI = 22.19 ± 0.64 kg/m(2), n = 10) and untrained (aged 20.25 ± 0.41 years, BMI = 22...
2017: PeerJ
https://www.readbyqxmd.com/read/28892419/the-effect-of-a-backpack-hip-strap-on-energy-expenditure-while-walking
#15
Jamie Pigman, William Sullivan, Steven Leigh, Peter A Hosick
Objective To examine the effect of backpack hip strap use on walking energy expenditure while carrying a loaded backpack. Background Previous studies have demonstrated that energy cost increases as the mass of the load carried increases. However, few investigations have focused on backpack carriage design. Methods Fifteen young, healthy, male subjects walked at a self-selected pace for 10 minutes in two backpack loading conditions: with a hip strap (strapped) and without a hip strap (nonstrapped). Oxygen consumption (VO2), rating of perceived exertion (RPE), respiratory exchange ratio (RER), and heart rate (HR) were monitored throughout each 10-minute trial...
September 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28891956/panax-ginseng-leaf-extracts-exert-anti-obesity-effects-in-high-fat-diet-induced-obese-rats
#16
Seul-Gi Lee, Yoon-Jeong Lee, Myeong-Hwan Jang, Tae-Ryong Kwon, Ju-Ock Nam
Recent studies have reported that the aerial parts of ginseng contain various saponins, which have anti-oxidative, anti-inflammatory, and anti-obesity properties similar to those of ginseng root. However, the leaf extracts of Korean ginseng have not yet been investigated. In this study, we demonstrate the anti-obesity effects of green leaf and dried leaf extracts (GL and DL, respectively) of ginseng in high-fat diet (HFD)-induced obese rats. The administration of GL and DL to HFD-induced obese rats significantly decreased body weight (by 96...
September 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28889722/effects-of-central-fibroblast-growth-factor-21-fgf21-in-energy-balance
#17
L Recinella, S Leone, C Ferrante, A Chiavaroli, C Di Nisio, S Martinotti, M Vacca, L Brunetti, G Orlando
Fibroblast growth factor 21 (FGF21) is known as a major metabolic regulator of glucose and lipid homeostasis. Continuous intracerebroventricular (i.c.v.) administration of FGF21 was found to modulate feeding and energy expenditure in rats with diet-induced obesity, suggesting a central effect by the peptide. In this context, in the present work, we studied the effects of a single central FGF21 administration (0.5-5 µg) on feeding and energy expenditure by evaluating locomotor activity, interscapular brown adipose tissue (BAT) weight, gene expression of uncoupling protein-1 (UCP-1) in BAT and plasma norepinephrine (NE) levels in Sprague-Dawley fed rats...
September 11, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28888087/modulation-of-transforming-growth-factor-%C3%AE-follistatin-signaling-and-white-adipose-browning-therapeutic-implications-for-obesity-related-disorders
#18
REVIEW
Shehla Pervin, Vineeta Singh, Alexandria Tucker, Javier Collazo, Rajan Singh
Obesity is a major risk factor for the development of diabetes, insulin resistance, dyslipidemia, cardiovascular disease and other related metabolic conditions. Obesity develops from perturbations in overall cellular bioenergetics when energy intake chronically exceeds total energy expenditure. Lifestyle interventions based on reducing total energy uptake and increasing activities including exercise have proved ineffective in the prevention and treatment of obesity because of poor adherence to such interventions for an extended period of time...
September 9, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28886439/chronic-high-sucrose-diet-increases-fibroblast-growth-factor-21-production-and-energy-expenditure-in-mice
#19
Ryuya Maekawa, Yusuke Seino, Hidetada Ogata, Masatoshi Murase, Atsushi Iida, Kaori Hosokawa, Erina Joo, Norio Harada, Shin Tsunekawa, Yoji Hamada, Yutaka Oiso, Nobuya Inagaki, Yoshitaka Hayashi, Hiroshi Arima
Excess carbohydrate intake causes obesity in humans. On the other hand, acute administration of fructose, glucose or sucrose in experimental animals has been shown to increase the plasma concentration of anti-obesity hormones such as glucagon-like peptide 1 (GLP-1) and Fibroblast growth factor 21 (FGF21), which contribute to reducing body weight. However, the secretion and action of GLP-1 and FGF21 in mice chronically fed a high-sucrose diet has not been investigated. To address the role of anti-obesity hormones in response to increased sucrose intake, we analyzed mice fed a high-sucrose diet, a high-starch diet or a normal diet for 15 weeks...
July 25, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28884411/role-of-calcitonin-gene-related-peptide-in-energy-metabolism
#20
REVIEW
William Gustavo Lima, Gleuber Henrique Marques-Oliveira, Thaís Marques da Silva, Valéria Ernestânia Chaves
PURPOSE: Calcitonin gene-related peptide (CGRP) is a neuropeptide produced by alternative tissue-specific splicing of the primary transcript of the CALC genes. CGRP is widely distributed in the central and peripheral nervous system, as well as in several organs and tissues. The presence of CGRP in the liver and brown and white adipose tissue suggests an effect of this neuropeptide on regulation of energy homeostasis. METHODS: In this review, we summarize the current knowledge of the effect of CGRP on the control of energy metabolism, primarily focusing on food intake, thermoregulation and lipid metabolism in adipose tissue, liver and muscle...
September 7, 2017: Endocrine
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