keyword
MENU ▼
Read by QxMD icon Read
search

Increase energy expenditure

keyword
https://www.readbyqxmd.com/read/28445429/exploring-the-behavioral-and-metabolic-phenotype-generated-by-re-introduction-of-the-ghrelin-receptor-in-the-ventral-tegmental-area
#1
Louise J Skov, Morten Jensen, Søren H Christiansen, Cecilia Ratner, David P D Woldbye, Birgitte Holst
Ghrelin receptor (Ghr-R) signaling in neurons of the ventral tegmental area (VTA) can modulate dopaminergic function and the reward-related effects of both palatable foods and drugs of abuse. In this study, we re-introduced the Ghr-R in VTA neurons in Ghr-R knockout mice (Ghr-R(VTA) mice) to specifically study the importance of the constitutively active Ghr-R for VTA neuronal signaling. Our results showed that re-introduction of the Ghr-R in the VTA had no impact on body weight or food intake under basal conditions...
April 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28443020/bgp-15-protects-against-oxaliplatin-induced-skeletal-myopathy-and-mitochondrial-reactive-oxygen-species-production-in-mice
#2
James C Sorensen, Aaron C Petersen, Cara A Timpani, Dean G Campelj, Jordan Cook, Adam J Trewin, Vanesa Stojanovska, Mathew Stewart, Alan Hayes, Emma Rybalka
Chemotherapy is a leading intervention against cancer. Albeit highly effective, chemotherapy has a multitude of deleterious side-effects including skeletal muscle wasting and fatigue, which considerably reduces patient quality of life and survivability. As such, a defense against chemotherapy-induced skeletal muscle dysfunction is required. Here we investigate the effects of oxaliplatin (OXA) treatment in mice on the skeletal muscle and mitochondria, and the capacity for the Poly ADP-ribose polymerase (PARP) inhibitor, BGP-15, to ameliorate any pathological side-effects induced by OXA...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28440048/ability-to-adjust-nocturnal-fat-oxidation-in-response-to-overfeeding-predicts-5-year-weight-gain-in-adults
#3
Corey A Rynders, Audrey Bergouignan, Elizabeth Kealey, Daniel H Bessesen
OBJECTIVE: To determine whether metabolic responses to short-term overfeeding predict longitudinal changes in body weight. METHODS: Twenty-four-hour energy expenditure (EE) and substrate utilization were measured at baseline in a room calorimeter following 3 days of eucaloric and hypercaloric feeding (40% excess) in a sample of lean adults (n: 34; age: 28 ± 2 y; BMI: 22 ± 3 kg/m(2) ). Body mass and fat mass (dual-energy x-ray absorptiometry) were measured annually for 5 years...
May 2017: Obesity
https://www.readbyqxmd.com/read/28439667/myricetin-induced-brown-adipose-tissue-activation-prevents-obesity-and-insulin-resistance-in-db-db-mice
#4
Tao Hu, Xiaoxue Yuan, Gang Wei, Haoshu Luo, Hyuek Jong Lee, Wanzhu Jin
PURPOSE: Myricetin, a dietary flavonoid, is effective in the treatment of obesity and insulin resistance by increasing glucose transport and lipogenesis in adipocyte and diminishing systemic inflammation in obesity. However, it has not been revealed yet whether myricetin is associated with brown adipose tissue (BAT) activation that tightly mediates systemic energy metabolism. Therefore, this study assessed whether myricetin activated brown adipose tissue in db/db mouse. METHODS: Myricetin (400 mg/kg) in distilled water was fed daily by oral gavage to leptin receptor-deficient db/db male mice at 4 weeks of age for 14 weeks...
April 24, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28438034/changes-in-physical-activity-following-total-hip-or-knee-arthroplasty-a-matched-case-control-study-from-the-epic-norfolk-cohort
#5
Toby Smith, Thomas Withers, Robert Luben, Catherine Sackley, Andy Jones, Alex MacGregor
OBJECTIVE: To assess self-reported physical activity changes pre- compared to post-operatively in patients undergoing total hip or knee arthroplasty, and to compare this to an age- and gender-matched cohort of people who have not undergone arthroplasty. DESIGN: Population-based prospective cohort study. SETTING: Norfolk, United Kingdom. SUBJECTS: People who had undergone hip or knee arthroplasty, compared to an age- and gender-matched non-arthroplasty cohort...
April 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28436723/asymptomatic-peripheral-artery-disease-can-limit-maximal-exercise-capacity-in-chronic-obstructive-pulmonary-disease-patients-regardless-of-airflow-obstruction-and-lung-hyperinflation
#6
Ernesto Crisafulli, Chiara Scelfo, Panagiota Tzani, Marina Aiello, Giuseppina Bertorelli, Alfredo Chetta
Background Silent/asymptomatic peripheral artery disease may occur in patients with chronic obstructive pulmonary disease, but it is poorly investigated. The primary aim of this study was to evaluate in chronic obstructive pulmonary disease patients the impact of asymptomatic/silent peripheral artery disease on maximal exercise capacity; the secondary aim was to search for predictors of peripheral artery disease. Methods We prospectively enrolled chronic obstructive pulmonary disease outpatients. Data on anthropometric characteristics, lung function, cardiopulmonary exercise test and ankle-brachial index were recorded...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28436331/lep-expression-and-its-role-in-obesity-and-type-2-diabetes
#7
Muhammad Imran Qadir, Zara Ahmed
Obesity is metabolic disorder that increases the risk of diabetes, heart disease, and other metabolic syndromes in human beings. One sign of diabetes is increased blood glucose levels in the body. Glucose levels increase due to problems with insulin secretion or insulin resistance. Maturity onset of diabetes of the young is more common in adults and occurs due to insulin resistance. Both diabetes and obesity are major problems that are responsible for the death of millions of individuals every year, worldwide...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/28433253/neuropeptide-s-increases-motor-activity-and-thermogenesis-in-the-rat-through-sympathetic-activation
#8
Takuya Ensho, Keiko Nakahara, Yoshihiro Suzuki, Noboru Murakami
The central role of neuropeptide S (NPS), identified as the endogenous ligand for GPR154, now named neuropeptide S receptor (NPSR), has not yet been fully clarified. We examined the central role of NPS for body temperature, energy expenditure, locomotor activity and adrenal hormone secretion in rats. Intracerebroventricular (icv) injection of NPS increased body temperature in a dose-dependent manner. Energy consumption and locomotor activity were also significantly increased by icv injection of NPS. In addition, icv injection of NPS increased the peripheral blood concentration of adrenalin and corticosterone...
April 13, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28432393/more-functions-of-torpor-and-their-roles-in-a-changing-world
#9
Julia Nowack, Clare Stawski, Fritz Geiser
Increased winter survival by reducing energy expenditure in adult animals is often viewed as the primary function of torpor. However, torpor has many other functions that ultimately increase the survival of heterothermic mammals and birds. In this review, we summarize new findings revealing that animals use torpor to cope with the conditions during and after natural disasters, including fires, storms, and heat waves. Furthermore, we suggest that torpor, which also prolongs longevity and was likely crucial for survival of mammals during the time of the dinosaur extinctions, will be advantageous in a changing world...
April 21, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28432150/specialist-generalist-model-of-body-temperature-regulation-can-be-applied-on-the-intraspecific-level
#10
Anna S Przybylska, Jan S Boratyński, Michał S Wojciechowski, Małgorzata Jefimow
According to theoretical predictions endothermic homeotherms can be classified as either thermal specialists and thermal generalists. In high cost environments thermal specialists are supposed to be more prone to use facultative heterothermy than generalists. We tested this hypothesis on the intraspecific level using laboratory male mice (C57BL/cmdb) fasted under different thermal conditions (20 and 10°C), and for different time periods (12-48 h). We predicted that variability of body temperature (Tb) and time spent with Tb below normothermy increase with the increase of environmental demands (duration of fasting and cold)...
April 21, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28431449/peripheral-and-central-glucocorticoid-signaling-contributes-to-positive-energy-balance-in-rats
#11
Tássia Karin Borba, Lígia Cristina Monteiro Galindo, Kelli Nogueira Ferraz-Pereira, Raquel da Silva Aragão, Ana Elisa Toscano, Omar Guzmán-Quevedo, Raul Manhães-de-Castro
The obesity epidemic has been the target of several studies to understand its etiology. The pathophysiological processes that take to obesity generally relate to the rupture of energy balance. This imbalance can result from environmental and/or endogenous events. Among the endogenous events, the hypothalamic-pituitary-adrenal axis, which promotes stress response via glucocorticoid activity, is considered a modulator of energy balance. However, it remains controversial whether the increase in plasma levels of glucocorticoids results in a positive or negative energy balance...
April 21, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28428010/a-strategy-of-faster-movements-used-by-elderly-humans-to-lift-objects-of-increasing-weight-in-ecological-context
#12
Thomas Hoellinger, Joseph McIntyre, Lena Jami, Sylvain Hanneton, Guy Cheron, Agnes Roby-Brami
It is not known whether, during the course of ageing, changes occur in the motor strategies used by the CNS for lifting objects of different weights. Here, we analysed the kinematics of object-lifting in two different healthy groups (young and elderly people) plus one well known deafferented patient (GL). The task was to reach and lift onto a shelf an opaque cylindrical object with changing weight. The movements of the hand and object were recorded with electromagnetic sensors. In an ecological context (i.e...
April 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28427699/people-with-ms-are-less-physically-active-than-healthy-controls-but-as-active-as-those-with-other-chronic-diseases-an-updated-meta-analysis
#13
D Kinnett-Hopkins, B Adamson, K Rougeau, R W Motl
BACKGROUND: There has been remarkable growth in research examining physical activity behavior (any bodily movement produced by skeletal muscle contraction that results in energy expenditure) among people living with multiple sclerosis (MS) over the past decade. The current meta-analysis quantified physical activity participation levels in persons with MS compared with non-diseased and other clinical populations. METHODS: We searched PUBMED, PsycINFO and Web of Science using the keywords physical activity, exercise, and physical fitness in conjunction with MS...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28424580/the-role-of-microrna-in-the-modulation-of-the-melanocortinergic-system
#14
REVIEW
Adel Derghal, Mehdi Djelloul, Jérôme Trouslard, Lourdes Mounien
The central control of energy balance involves a highly regulated neuronal network within the hypothalamus and the dorsal vagal complex. In these structures, pro-opiomelanocortin (POMC) neurons are known to reduce meal size and to increase energy expenditure. In addition, leptin, a peripheral signal that relays information regarding body fat content, modulates the activity of melanocortin pathway neurons including POMC-, Agouti-related peptide (AgRP)/Neuropeptide Y (NPY)-, melanocortin receptors (MC3R and MC4R)-expressing neurons...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28424263/the-kielin-chordin-like-protein-kcp-attenuates-high-fat-diet-induced-obesity-and-metabolic-syndrome-in-mice
#15
Abdul Soofi, Katherine I Wolf, Margo P Emont, Nathan Qi, Gabriel Martinez-Santibanez, Edward Grimley, Wesam Ostwani, Gregory R Dressler
Obesity and its associated complications, such as insulin resistance and non-alcoholic fatty liver disease, are reaching epidemic proportions. In mice, the TGF-beta superfamily is implicated in the regulation of white and brown adipose tissue differentiation. The Kielin/chordin-like Protein (KCP) is a secreted regulator of the TGF-beta superfamily pathways that can inhibit both TGF-beta and activin signals while enhancing bone morphogenetic protein (BMP) signaling. However, KCP's effects on metabolism and obesity have not been studied in animal models...
April 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28423914/current-views-on-neuropeptide-y-and-diabetes-related-atherosclerosis
#16
Wei-Wei Sun, Ping Zhu, Yan-Chuan Shi, Chen-Liang Zhang, Xu-Feng Huang, Shi-Yu Liang, Zhi-Yuan Song, Shu Lin
Diabetes-induced atherosclerotic cardiovascular disease is the leading cause of death of diabetic patients. Neuronal regulation plays a critical role in glucose metabolism and cardiovascular function under physiological and pathological conditions, among which, neurotransmitter neuropeptide Y has been shown to be closely involved in these two processes. Elevated central neuropeptide Y level promotes food intake and reduces energy expenditure, thereby increasing adiposity. Neuropeptide Y is co-localized with noradrenaline in central and sympathetic nervous systems...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28422755/%C3%AE-klotho-deficiency-protects-against-obesity-through-a-crosstalk-between-liver-microbiota-and-brown-adipose-tissue
#17
Emmanuel Somm, Hugues Henry, Stephen J Bruce, Sébastien Aeby, Marta Rosikiewicz, Gerasimos P Sykiotis, Mohammed Asrih, François R Jornayvaz, Pierre Damien Denechaud, Urs Albrecht, Moosa Mohammadi, Andrew Dwyer, James S Acierno, Kristina Schoonjans, Lluis Fajas, Gilbert Greub, Nelly Pitteloud
β-Klotho (encoded by Klb) is the obligate coreceptor mediating FGF21 and FGF15/19 signaling. Klb-/- mice are refractory to beneficial action of pharmacological FGF21 treatment including stimulation of glucose utilization and thermogenesis. Here, we investigated the energy homeostasis in Klb-/- mice on high-fat diet in order to better understand the consequences of abrogating both endogenous FGF15/19 and FGF21 signaling during caloric overload. Surprisingly, Klb-/- mice are resistant to diet-induced obesity (DIO) owing to enhanced energy expenditure and BAT activity...
April 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28421289/adult-male-northern%C3%A2-elephant-seals-maintain-high-rates-of-glucose-production-during-extended-breeding-fasts
#18
Daniel E Crocker, Brian K Wenzel, Cory D Champagne, Dorian S Houser
Many species undergo natural fasts as part of their life histories. Extended fasting is associated with increased β-oxidation of fatty acids and reduced oxidation of glucose to minimize commitment of body protein to gluconeogenesis. However, the metabolic strategies used to sustain extended fasts simultaneous with high rates of energy expenditure are not well understood. Studies in fasting adult female and weanling northern elephant seals (NES) have revealed high rates of endogenous glucose production (EGP) under constraints of high nutrient demand for lactation or development but relatively low rates of metabolism...
April 18, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28420221/a-narrative-review-actigraphy-as-an-objective-assessment-of-perioperative-sleep-and-activity-in-pediatric-patients
#19
REVIEW
Nicole Conrad, Joelle Karlik, Amy Lewandowski Holley, Anna C Wilson, Jeffrey Koh
Sleep is an important component of pediatric health and is crucial for cognitive development. Actigraphy is a validated, objective tool to capture sleep and movement data that is increasingly being used in the perioperative context. The aim of this review is to present recent pediatric studies that utilized actigraphy in the perioperative period, highlight gaps in the literature, and provide recommendations for future research. A literature search was completed using OVID and PubMed databases and articles were selected for inclusion based on relevance to the topic...
April 18, 2017: Children
https://www.readbyqxmd.com/read/28420089/suppression-of-ghs-r-in-agrp-neurons-mitigates-diet-induced-obesity-by-activating-thermogenesis
#20
Chia-Shan Wu, Odelia Y N Bongmba, Jing Yue, Jong Han Lee, Ligen Lin, Kenji Saito, Geetali Pradhan, De-Pei Li, Hui-Lin Pan, Allison Xu, Shaodong Guo, Yong Xu, Yuxiang Sun
Ghrelin, an orexigenic hormone released primarily from the gut, signals the hypothalamus to stimulate growth hormone release, enhance appetite and promote weight gain. The ghrelin receptor, aka Growth Hormone Secretagogue Receptor (GHS-R), is highly expressed in the brain, with highest expression in Agouti-Related Peptide (AgRP) neurons of the hypothalamus. We recently reported that neuron-specific deletion of GHS-R completely prevents diet-induced obesity (DIO) in mice by activating non-shivering thermogenesis...
April 14, 2017: International Journal of Molecular Sciences
keyword
keyword
23462
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"