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https://www.readbyqxmd.com/read/29169230/ultrasonographic-features-of-pure-ductal-carcinoma-italic-in-situ-italic-of-the-breast-correlations-with-pathologic-features-and-biological-markers
#1
Hwajin Cha, Yun-Woo Chang, Eun Ji Lee, Ji Young Hwang, Hyun Joo Kim, Eun Hye Lee, Jung Kyu Ryu
Purpose: The purpose of this study was to evaluate the ultrasonographic features of pure ductal carcinoma in situ (DCIS) of the breast and to evaluate the correlations of ultrasonographic features with pathologic and biological features. Methods: A total of 141 lesions in 138 women with pure DCIS who underwent preoperative breast ultrasonography were retrospectively reviewed. Ultrasonographic features were analyzed using the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) ultrasonography lexicon and the diagnostic criteria of the Japan Society of Ultrasonics in Medicine...
October 13, 2017: Ultrasonography
https://www.readbyqxmd.com/read/29169227/korean-red-ginseng-excitation-of-paraventricular-nucleus-neurons-via-non-nmda-glutamate-receptor-activation-in-mice
#2
Yiming Shen, Janardhan P Bhattarai, Soo Joung Park, Gyu Seung Lee, Pan Dong Ryu, Seong Kyu Han
It has been reported that Korean red ginseng (KRG) as a valuable and important traditional medicine has various effects on central nervous system suggesting its complicated actions. Paraventricular nucleus (PVN) neurons of hypothalamus play a critical role for stress responses and hormone secretions. Although many studies have reported the action mechanisms of KRG on various cell and systems, the direct membrane effects of KRG on the PVN neurons which are involved in stress response are still poorly understood...
November 23, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29169222/metagenomic-approach-to-identifying-foodborne-pathogens-on-chinese-cabbage
#3
Daeho Kim, Sanghyun Hong, You-Tae Kim, Sangryeol Ryu, Hyeun Bum Kim, Ju-Hoon Lee
Foodborne illness represents a major threat to public health frequently attributed to pathogenic microorganisms on fresh produce. Recurrent outbreaks often come from vegetables that are grown close to or within the ground. Therefore, the first step to understanding the public health risk of microorganisms on fresh vegetables is to identify and describe microbial communities. We investigated phyllospheres on Chinese cabbage (Brassica rapa subsp. pekinensis, n=54). 16S rRNA gene amplicon sequencing targeting the V5-V6 region of 16S rRNA genes was conducted by employing the Illumina MiSeq system...
November 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29169212/complications-of-co2-insufflation-during-endoscopic-vein-harvesting
#4
REVIEW
Alejandro Suarez-Pierre, Yusuke Terasaki, J Trent Magruder, Anubhav Kapoor, Michael C Grant, Jennifer S Lawton
Over the past few decades, the use of endoscopic harvest of the saphenous vein has gained popularity due to a significant reduction in rates of wound infection and improved cosmesis. The widespread adoption of this technique has introduced a set of complications associated with the use CO2 insufflation which facilitates exposure during the vein harvest. We describe a case of pneumoperitoneum with systemic acidosis and subcutaneous air following endoscopic vein harvest for coronary artery bypass grafting and review the complications that may arise from CO2 insufflation during endoscopic vein harvesting...
November 23, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29169195/wide-field-piecemeal-cold-snare-polypectomy-of-large-sessile-serrated-polyps-without-a-submucosal-injection-is-safe
#5
David J Tate, Halim Awadie, Farzan F Bahin, Lobke Desomer, Ralph Lee, Steven J Heitman, Kathleen Goodrick, Michael J Bourke
Background and study aims Large series suggest endoscopic mucosal resection is safe and effective for the removal of large (≥ 10 mm) sessile serrated polyps (SSPs), but it exposes the patient to the risks of electrocautery, including delayed bleeding. We examined the feasibility and safety of piecemeal cold snare polypectomy (pCSP) for the resection of large SSPs. Methods Sequential large SSPs (10 - 35 mm) without endoscopic evidence of dysplasia referred over 12 months to a tertiary endoscopy center were considered for pCSP...
November 23, 2017: Endoscopy
https://www.readbyqxmd.com/read/29169181/inflammatory-cytokine-il-8-cxcl8-promotes-tumour-escape-from-hepatocyte-induced-dormancy
#6
Ahmad S Khazali, Amanda M Clark, Alan Wells
BACKGROUND: Breast cancers can recur after a long latency period following 'successful' primary treatments. Chronic inflammation significantly correlates with reduced diseased-free survival in breast cancer patients and could be a point of intervention to prevent recurrence. Liver is among the main sites of breast cancer recurrence. Thus, we hypothesise that inflammatory signals from hepatic stellate cells, the major inflammatory regulators in the sinusoid, could stimulate dormant cancer cells to emerge...
November 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29169174/melatonin-induced-changes-in-cytosolic-calcium-might-be-responsible-for-apoptosis-induction-in-tumour-cells
#7
Barbora Chovancova, Sona Hudecova, Lubomira Lencesova, Petr Babula, Ingeborg Rezuchova, Adela Penesova, Marian Grman, Roman Moravcik, Michal Zeman, Olga Krizanova
BACKGROUND/AIMS: Melatonin is a hormone transferring information about duration of darkness to the organism and is known to modulate several signaling pathways in the cells, e.g. generation of endoplasmic reticulum stress, oxidative status of the cells, etc. Melatonin has been shown to exert antiproliferative and cytotoxic effects on various human cancers. We proposed that this hormone can differently affect tumour cells and healthy cells. METHODS: We compared the effect of 24 h melatonin treatment on calcium transport (by fluorescent probes FLUO-3AM and Rhod-5N), ER stress (determined as changes in the expression of CHOP, XBP1 and fluorescently, using Thioflavin T), ROS formation (by CellROX® Green/Orange Reagent) and apoptosis induction (by Annexin-V-FLUOS/propidiumiodide) in two tumour cell lines - ovarian cancer cell line A2780 and stable cell line DLD1 derived from colorectal carcinoma, with non-tumour endothelial cell line EA...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169167/structural-pulmonary-abnormalities-still-evident-in-schoolchildren-with-new-bronchopulmonary-dysplasia
#8
Eveliina Ronkainen, Marja Perhomaa, Lauri Mattila, Mikko Hallman, Teija Dunder
BACKGROUND: A new pattern of bronchopulmonary dysplasia (BPD) has emerged with the improved survival of preterm children. OBJECTIVES: Our aim was to characterize structural abnormalities associated with new BPD and to evaluate whether the severity of high-resolution computed tomography (HRCT) changes is associated with lung function. METHODS: HRCT scans were performed on 21 schoolchildren with a history of new BPD (mild, n = 9; moderate, n = 4; and severe, n = 8) with a mean age of 12...
November 24, 2017: Neonatology
https://www.readbyqxmd.com/read/29169158/potential-targets-and-clinical-value-of-mir-224-5p-in-cancers-of-the-digestive-tract
#9
Lu Zhang, Lan-Shan Huang, Gang Chen, Zhen-Bo Feng
BACKGROUND/AIMS: MicroRNAs participate in various biological processes in malignant tumors. However, the mechanisms of miR-224-5p in digestive system cancers are not fully understood. A comprehensive investigation of the clinical value and potential targets of miR-224-5p in cancers of the digestive tract is necessary. METHODS: Expression profiling data and related-prognostic data of miR-224-5p were acquired from Gene Expression Omnibus, The Cancer Genome Atlas, ArrayExpress, and published literature...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169157/tnf-%C3%AE-regulates-mast-cell-functions-by-inhibiting-cell-degranulation
#10
Yuwei Gao, Baixue Xu, Peng Zhang, Yanlong He, Xin Liang, Jianwen Liu, Jiyu Li
BACKGROUND/AIMS: The aim of this study was to investigate the involvement of inducible co-stimulatory ligand (ICOSL) expression in stimulation of mast cells (MCs) by TNF-α and the ability of TNF-α stimulation of MCs to influence CD4+ T cell differentiation and function. The mechanisms underlying TNF-α stimulation of MCs were also explored. METHODS: Mast cells and CD4+ T cells were prepared from C57BL/6 mice (aged 6-8 weeks). ICOSL expression by MCs was measured by real-time PCR and flow cytometry, and levels of IL-4, IL-10 and IFN-γ were measured by ELISA...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169147/c-type-lectin-receptors-in-anti-fungal-immunity
#11
REVIEW
Moe Shiokawa, Sho Yamasaki, Shinobu Saijo
Host immune systems are constantly engaged with fungal pathogens which are common in environments as well as in healthy human skin and mucosa. C-type lectin receptors (CLRs) are expressed in myeloid cells and play central roles in host defenses against fungal infections by coordinating innate and adaptive immune systems. Upon ligand binding, CLRs stimulate cellular responses by inducing the production of cytokines and reactive oxygen species via the Syk/CARD9 signaling pathway, leading to fungal elimination...
November 20, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29169146/how-bacteria-control-the-crispr-cas-arsenal
#12
REVIEW
Lina M Leon, Senén D Mendoza, Joseph Bondy-Denomy
CRISPR-Cas systems are adaptive immune systems that protect their hosts from predation by bacteriophages (phages) and parasitism by other mobile genetic elements (MGEs). Given the potent nuclease activity of CRISPR effectors, these enzymes must be carefully regulated to minimize toxicity and maximize anti-phage immunity. While attention has been given to the transcriptional regulation of these systems (reviewed in [1]), less consideration has been given to the crucial post-translational processes that govern enzyme activation and inactivation...
November 20, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29169144/targeting-the-wnt-beta-catenin-pathway-in-cancer-update-on-effectors-and-inhibitors
#13
REVIEW
Nithya Krishnamurthy, Razelle Kurzrock
The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular functions like stem cell regeneration and organogenesis. Several intra-cellular signal transduction pathways are induced by Wnt, notably the Wnt/beta-catenin dependent pathway or canonical pathway and the non-canonical or beta-catenin-independent pathway, the latter includes the Wnt/Ca2+ and Planar Cell Polarity pathway (PCP). Wnt activation occurs at the intestinal crypt floor, and is critical to optimal maintenance of stem cells...
November 13, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29169136/degradation-of-diethyl-phthalate-dep-by-uv-persulfate-an-experiment-and-simulation-study-of-contributions-by-hydroxyl-and-sulfate-radicals
#14
Ziying Wang, Yisheng Shao, Naiyun Gao, Xian Lu, Na An
Degradation of diethyl phthalate (DEP) by ultraviolet/persulfate (UV/PS) process at different reaction conditions was evaluated. DEP can be degraded effectively via this process. Both tert-butyl (TBA) and methanol (MeOH) inhibited the degradation of DEP with MeOH having a stronger impact than TBA, suggesting sulfate radical () and hydroxyl radical (HO) both existed in the reaction systems studied. The second-order rate constants of DEP reacting with and HO were calculated to be (6.4±0.3)×10(7) M(-1)s(-1) and (3...
November 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/29169135/nitrogen-removal-capacity-and-bacterial-community-dynamics-of-a-canon-biofilter-system-at-different-organic-matter-concentrations
#15
María J García-Ruiz, Paula Maza-Márquez, Jesús González-López, Francisco Osorio
Three Canon bench-scale bioreactors with a volume of 2 L operating in parallel were configured as submerged biofilters. In the present study we investigated the effects of a high ammonium concentration (320 mgNH4(+)· L(-1)) and different concentrations of organic matter (0, 100 and 400 mgCOD·L(-1)) on the nitrogen removal capacity and the bacterial community structure. After 60 days, the Canon biofilters operated properly under concentrations of 0 and 100 mgCOD·L(-1) of organic matter, with nitrogen removal efficiencies up to 85%...
November 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/29169134/the-comparison-of-greenhouse-gas-emissions-in-sewage-treatment-plants-with-different-treatment-processes
#16
Shuhei Masuda, Itsumi Sano, Toshimasa Hojo, Yu-You Li, Osamu Nishimura
Greenhouse gas emissions from different sewage treatment plants: oxidation ditch process, double-circulated anoxic-oxic process and anoxic-oxic process were evaluated based on the survey. The methane and nitrous oxide characteristics were discussed based on the gaseous and dissolved gas profiles. As a result, it was found that methane was produced in the sewer pipes and the primary sedimentation tank. Additionally, a ventilation system would promote the gasification of dissolved methane in the first treatment units...
November 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29169119/obp-fused-with-cell-penetrating-peptides-promotes-liposomal-transduction
#17
Filipa Gonçalves, Tarsila G Castro, Eugénia Nogueira, Ricardo Pires, Carla Silva, Artur Ribeiro, Artur Cavaco-Paulo
Cell-penetrating peptides (CPPs) have been applied as novel transport systems with the ability to facilitate the delivery of peptides, proteins, and oligonucleotides into cells. Herein, we designed different fusion proteins composed by pig odorant binding protein (OBP-I) and three CPPs, namely Tat, pVEC and Pep-1. A new methodology using liposomes as reservoirs and OBP:CPPs as carriers was developed as an advanced system to capture odorant molecules. 1-aminoanthracene (1-AMA) was used as a model molecule to evaluate the transduction ability of OBP:CPPs into the reservoirs...
November 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29169111/identification-of-phenolic-components-via-lc-ms-analysis-and-biological-activities-of-two-centaurea-species-c-drabifolia-subsp-drabifolia-and-c-lycopifolia
#18
Gokhan Zengin, Dimitrina Zheleva-Dimitrova, Reneta Gevrenova, Paraskev Nedialkov, Andrei Mocan, Ana Ćirić, Jasmina Glamočlija, Marina Soković, Abdurrahman Aktumsek, M Fawzi Mahomoodally
The Centaurea genus has great potential in traditional systems and has attracted much interest in the design of novel drug formulations. The present study was focused on the chemical fingerprints and biological properties of Centaurea drabifolia subsp. drabifolia and Centaurea lycopifolia extracts. Spectrophotometric and LC-MS techniques were used to establish the chemical profiles of the studied extracts. Enzyme inhibitory potential was assessed against key enzymes linked to global health problems, namely neurodegenerative diseases (acetylcholinesterase), pigmentation (tyrosinase), and diabetes (α-amylase and α-glucosidase)...
November 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29169105/constitutive-redox-and-phosphoproteome-changes-in-multiple-herbicide-resistant-avena-fatua-l-are-similar-to-those-of-systemic-acquired-resistance-and-systemic-acquired-acclimation
#19
Erin E Burns, Barbara K Keith, Mohammed Y Refai, Brian Bothner, William E Dyer
Plants are routinely confronted with numerous biotic and abiotic stressors, and in response have evolved highly effective strategies of systemic acquired resistance (SAR) and systemic acquired acclimation (SAA), respectively. A much more evolutionarily recent abiotic stress is the application of herbicides to control weedy plants, and their intensive use has selected for resistant weed populations that cause substantial crop yield losses and increase production costs. Non-target site resistance (NTSR) to herbicides is rapidly increasing worldwide and is associated with alterations in generalized stress defense networks...
November 20, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29169095/bioactivity-and-properties-of-an-adhesive-system-functionalized-with-an-experimental-niobium-based-glass
#20
Karina Kato Carneiro, Taylan Pinheiro Araujo, Edilausson Moreno Carvalho, Marcia Margarete Meier, Auro Tanaka, Ceci Nunes Carvalho, José Bauer
OBJECTIVE: This study evaluated the incorporation of niobophosphate bioactive glass (NbG) fillers into a commercial adhesive resin. MATERIALS AND METHODS: The silanized (NbGs) or non-silanized (NbG) NbG was added to the commercial adhesive system One Step (OS) at 30% by weight; unfilled adhesive served as control. The bioactivity of adhesives was analyzed by SEM and FTIR/ATR after 28 days in PBS. The adhesives were evaluated as regards microtensile bond strength immediately and after six months (n = 6); degree of conversion (n = 3), microhardness (n = 5); and radiopacity (n = 3)...
November 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
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