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https://www.readbyqxmd.com/read/29782312/naturalistic-driving-study-investigating-self-regulation-behavior-in-early-alzheimer-s-disease-a-pilot-study
#1
Laurence Paire-Ficout, Sylviane Lafont, Fanny Conte, Amandine Coquillat, Colette Fabrigoule, Joël Ankri, Frédéric Blanc, Cécilia Gabel, Jean-Luc Novella, Isabella Morrone, Rachid Mahmoudi
BACKGROUND: Because cognitive processes decline in the earliest stages of Alzheimer's disease (AD), the driving abilities are often affected. The naturalistic driving approach is relevant to study the driving habits and behaviors in normal or critical situations in a familiar environment of participants. OBJECTIVE: This pilot study analyzed in-car video recordings of naturalistic driving in patients with early-stage AD and in healthy controls, with a special focus on tactical self-regulation behavior...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29781575/brn2-a-pouerful-driver-of-melanoma-phenotype-switching-and-metastasis
#2
REVIEW
Mitchell E Fane, Yash Chhabra, Aaron G Smith, Richard A Sturm
The POU domain family of transcription factors play a central role in embryogenesis and are highly expressed in neural crest cells and the developing brain. BRN2 is a class III POU domain protein that is a key mediator of neuroendocrine and melanocytic development and differentiation. While BRN2 is a central regulator in numerous developmental programs, it has also emerged as a major player in the biology of tumourigenesis. In melanoma, BRN2 has been implicated as one of the master regulators of the acquisition of invasive behavior within the phenotype-switching model of progression...
May 21, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29780807/a-critical-review-of-the-bacterial-baptism-hypothesis-and-the-impact-of-cesarean-delivery-on-the-infant-microbiome
#3
REVIEW
Lisa F Stinson, Matthew S Payne, Jeffrey A Keelan
Numerous studies suggest that infants delivered by cesarean section are at a greater risk of non-communicable diseases than their vaginal counterparts. In particular, epidemiological studies have linked Cesarean delivery with increased rates of asthma, allergies, autoimmune disorders, and obesity. Mode of delivery has also been associated with differences in the infant microbiome. It has been suggested that these differences are attributable to the "bacterial baptism" of vaginal birth, which is bypassed in cesarean deliveries, and that the abnormal establishment of the early-life microbiome is the mediator of later-life adverse outcomes observed in cesarean delivered infants...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29780740/impact-of-sense-of-coherence-on-oral-health-among-bus-drivers-a-cross-sectional-study
#4
Shaik Ijaz Ahmed, Kudlur Maheswarappa Sudhir, V Chandra Sekhara Reddy, R V S Krishna Kumar, G Srinivasulu, Athuluru Deepthi
Aim and Objectives: To assess the sense of coherence (SOC) and the impact of SOC on oral hygiene behaviors and oral health status among bus drivers in Nellore district, Andhra Pradesh. Materials and Methods: A descriptive cross-sectional study was conducted during August-September 2017. Cluster random sampling methodology was used for the selection of drivers. Five depots were randomly selected from the list of various Andhra Pradesh State Road Transport Corporation depots in Nellore district...
March 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29779682/predicting-alpha-synuclein-pathology-by-rem-sleep-behavior-disorder-diagnosis
#5
David R Shprecher, Charles H Adler, Nan Zhang, Joseph G Hentz, Geidy E Serrano, Brittany N Dugger, Holly A Shill, Rodolfo Savica, John N Caviness, Marwan N Sabbagh, Christine M Belden, Erika Driver-Dunckley, Shyamal H Mehta, Lucia I Sue, Kathryn J Davis, Edward Zamrini, Thomas G Beach
Inability to accurately diagnose Lewy type alpha-synucleinopathy (LTS) pre-mortem has been a major obstacle to clinical care and research. Probable REM sleep behavior disorder (PRBD) diagnosed with support of instruments such as the Mayo Sleep Questionnaire (MSQ) may provide a cost effective means of predicting LTS. Since 2007, 602 subjects in the Arizona Study of Aging and Neurodegenerative Disorders had clinician assessment for PRBD (298 with, 304 without support of the MSQ), completed cognitive and movement examinations, and had neuropathological assessment...
May 17, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29779223/gene-editing-vectors-for-studying-nicotinic-acetylcholine-receptors-in-cholinergic-transmission
#6
Can Peng, Yijin Yan, Veronica J Kim, Staci E Engle, Jennifer N Berry, J Michael McIntosh, Rachael L Neve, Ryan M Drenan
Nicotinic acetylcholine receptors (nAChRs), prototype members of the cys-loop ligand gated ion channel family, are key mediators of cholinergic transmission in the central nervous system. Despite their importance, technical gaps exist in our ability to dissect the function of individual subunits in the brain. To overcome these barriers, we designed CRISPR/Cas9 small guide RNA sequences (sgRNAs) for production of loss-of-function alleles in mouse nAChR genes. These sgRNAs were validated in vitro via deep sequencing...
May 19, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29776523/comparison-of-self-report-and-objective-measures-of-driving-behavior-and-road-safety-a-systematic-review
#7
Sherrie-Anne Kaye, Ioni Lewis, James Freeman
INTRODUCTION: This research systematically reviewed the existing literature in regards to studies which have used both self-report and objective measures of driving behavior. The objective of the current review was to evaluate disparities or similarities between self-report and objective measures of driving behavior. METHODS: Searches were undertaken in the following electronic databases, PsycINFO, PubMed, and Scopus, for peer-reviewed full-text articles that (1) focused on road safety, and (2) compared both subjective and objective measures of driving performance or driver safety...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29776522/causal-attribution-in-explanations-of-near-crash-events-behind-the-wheel-and-its-relationship-to-comparative-judgments
#8
Blazej Palat, Patricia Delhomme
INTRODUCTION: The development of skills essential for avoiding crashes depends, in particular, on how drivers explain the causes of dangerous driving behaviors that resulted in a near crash. Here, we analyze causes attributed to such behaviors by car drivers in a self-report study. We explore the relationships between the dimensions of causal attribution, attribution of responsibility for the near crash, and drivers' comparative judgments. METHOD: For approximately two months, drivers used logbooks to document the near crashes that occurred during their trips...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29776519/how-many-crashes-are-caused-by-driver-interaction-with-passengers-a-meta-analysis-approach
#9
Athanasios Theofilatos, Apostolos Ziakopoulos, Eleonora Papadimitriou, George Yannis
INTRODUCTION: Conversation and other interactions with passengers while driving induce a level of distraction to the person driving. METHOD: This paper conducts a qualitative literature review on the effect of passenger interaction on road safety and then extends it by using meta-analysis techniques. RESULTS: The literature review indicates that the distraction due to passengers is a very frequent risk factor, with detrimental effects to various driving behavior and safety measures (e...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29774524/%C3%AE-e-catenin-is-a-candidate-tumor-suppressor-for-the-development-of-e-cadherin-expressing-lobular-type-breast-cancer
#10
Jolien S de Groot, Max A K Rätze, Miranda van Amersfoort, Tanja Eisemann, Eva J Vlug, Mijanou T Niklaas, Suet-Feung Chin, Carlos Caldas, Paul J van Diest, Jos Jonkers, Johan de Rooij, Patrick W B Derksen
Mutational inactivation of E-cadherin (CDH1) is the main driver of invasive lobular breast cancer (ILC), although approximately 10-15% of all ILCs retain membrane-localized E-cadherin, despite the presence of an apparent non-cohesive and invasive lobular growth pattern. Given that ILC is dependent on constitutive actomyosin contraction for tumor development and progression, we used a combination of cell systems and in vivo experiments to investigate the consequences of α-catenin (CTNNA1) loss in the regulation of anchorage independence of non-invasive breast carcinoma...
May 17, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29771543/making-stronger-causal-inferences-accounting-for-selection-bias-in-associations-between-high-performance-work-systems-leadership-and-employee-and-customer-satisfaction
#11
Joseph A Schmidt, Dionne M Pohler
We develop competing hypotheses about the relationship between high performance work systems (HPWS) with employee and customer satisfaction. Drawing on 8 years of employee and customer survey data from a financial services firm, we used a recently developed empirical technique-covariate balanced propensity score (CBPS) weighting-to examine if the proposed relationships between HPWS and satisfaction outcomes can be explained by reverse causality, selection effects, or commonly omitted variables such as leadership behavior...
May 17, 2018: Journal of Applied Psychology
https://www.readbyqxmd.com/read/29770198/recent-advances-in-managing-understanding-meningioma
#12
REVIEW
Nawal Shaikh, Karan Dixit, Jeffrey Raizer
Meningiomas are the most common adult primary intracranial tumor. Despite their higher incidence, there have not-until recently-been as many advances in understanding and managing meningiomas. Thus far, two broad classes of meningiomas have emerged on the basis of their mutational profile: those driven by neurofibromatosis 2 (NF2) inactivation and those with non-NF2 driver gene alterations, such as mammalian target of rapamycin and Hedgehog, Wingless/b-catenin, Notch, transforming growth factor-b receptor, mitogen-activated protein kinase, and phospholipase C pathway alterations...
2018: F1000Research
https://www.readbyqxmd.com/read/29769562/common-drivers-of-seasonal-movements-on-the-migration-residency-behavior-continuum-in-a-large-herbivore
#13
Jodie Martin, Vincent Tolon, Nicolas Morellet, Hugues Santin-Janin, Alain Licoppe, Claude Fischer, Jérôme Bombois, Patrick Patthey, Elias Pesenti, Delphine Chenesseau, Sonia Saïd
This study aimed to (1) identify the scale of environmental drivers of seasonal movements on the migration - residency behavior continuum in a large herbivore species and to (2) test the hypothesis that the same environmental drivers and spatio-temporal scaling should influence spatial processes in both migrants (long distance migration) and residents (short distance range shifts). We performed a comparative analysis of the influence of plant phenology and snow cover duration on seasonal movements of five partially migrating red deer populations with contrasting environmental conditions, at the seasonal range scale and at the study area scale...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764611/regenerative-braking-failures-in-battery-electric-vehicles-and-their-impact-on-the-driver
#14
Peter Cocron, Isabel Neumann, Maria Kreußlein, Daniel Wanner, Maxim Bierbach, Josef F Krems
A unique feature of battery electric vehicles (BEV) is their regenerative braking system (RBS) to recapture kinetic energy in deceleration maneuvers. If such a system is triggered via gas pedal, most deceleration maneuvers can be executed by just using this pedal. This impacts the driving task as different deceleration strategies can be applied. Previous research has indicated that a RBS failure leading to a sudden reduced deceleration represents an adverse event for BEV drivers. In the present study, we investigated such a failure's impact on the driver's evaluation and behavior...
September 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29760903/function-related-drivers-of-skull-morphometric-variation-and-sexual-size-dimorphism-in-a-subterranean-rodent-plateau-zokor-eospalax-baileyi
#15
Junhu Su, Ibrahim M Hegab, Weihong Ji, Zhibiao Nan
Sexual dimorphism is prevalent in most living organisms. The difference in size between sexes of a given species is generally known as sexual size dimorphism (SSD). The magnitude of the SSD is determined by Rensch's rule where size dimorphism increases with increasing body size when the male is the larger sex and decreases with increasing average body size when the female is the larger sex. The unique underground environment that zokors ( Eospalax baileyi ) live under in the severe habitat of the Qinghai-Tibetan Plateau (QTP) could create SSD selection pressures that may or may not be supported by Rensch's rule, making this scientific question worthy of investigation...
May 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29760668/implicit-motives-as-determinants-of-networking-behaviors
#16
Hans-Georg Wolff, Julia G Weikamp, Bernad Batinic
In today's world of work, networking behaviors are an important and viable strategy to enhance success in work and career domains. Concerning personality as an antecedent of networking behaviors, prior studies have exclusively relied on trait perspectives that focus on how people feel, think, and act. Adopting a motivational perspective on personality, we enlarge this focus and argue that beyond traits predominantly tapping social content, motives shed further light on instrumental aspects of networking - or why people network...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29758199/pafah1b2-is-a-hif1a-target-gene-and-promotes-metastasis-in-pancreatic-cancer
#17
Can Ma, Yan Guo, Yan Zhang, Aixia Duo, Yitao Jia, Ci Liu, Binghui Li
Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B2) plays important roles in inflammation and anaphylaxis. However, its primary function in pancreatic cancer remains unclear. In the current study, we report that PAFAH1B2 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and correlated inversely with patient survival. PAFAH1B2 overexpression induced epithelial-mesenchymal transition (EMT), migration and invasion in vitro and metastasis in vivo. Conversely, silencing PAFAH1B2 inhibited these aggressive phenotypes...
May 11, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29757689/effect-of-traffic-density-on-drivers-lane-change-and-overtaking-maneuvers-in-freeway-situation-a-driving-simulator-based-study
#18
Liu Yang, Xiaomeng Li, Wei Guan, H Michael Zhang, Lingling Fan
OBJECTIVE: The aim of this study is to examine the effect of traffic density on drivers' lane change and overtaking maneuvers. The differences between drivers' left and right lane-changing/overtaking maneuvers were also investigated. METHOD: A driving simulator experiment was conducted and 24 participants took part in this experiment. Based on the driving simulation data, lane change frequency, time duration, average speed and acceleration were extracted as key variables of lane change maneuvers; overtaking frequency, overtaking duration, initial overtaking distance and headway, instantaneous speed and acceleration before overtaking were analyzed as the key overtaking variables...
May 14, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29757075/unpacking-racial-ethnic-disparities-in-prenatal-care-use-the-role-of-individual-household-and-area-level-characteristics
#19
Tiffany L Green
OBJECTIVE: To identify the contributions of individual-, household-, and area-level characteristics to disparities in the use of prenatal care (PNC). METHODS: This study used individual-level data from the 2001 Early Childhood Longitudinal Study-Birth Cohort linked to county-level U.S. Census data (N ≈ 5,200). I used nonlinear regression decomposition to quantify the contributions of several groups of factors-maternal health and pregnancy characteristics, preconception health behaviors, insurance coverage, PNC location, socioeconomic status (SES), and the social/economic and healthcare environments-to PNC disparities...
May 14, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29754190/allergic-and-immunologic-perspectives-of-inflammatory-bowel-disease
#20
REVIEW
Kofi Clarke, Jayakrishna Chintanaboina
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory condition primarily involving the gastrointestinal tract. It includes Crohn's disease (CD), ulcerative colitis (UC), and a less common phenotype-indeterminate colitis. It is thought to result from a complex interplay of environmental, microbial, and host factors including genetic factors, although the exact mechanism is not known. Dietary factors have been shown to play a role in the pathogenesis of IBD and can potentially alter the intestinal microbiota as well as disrupt the immune function in the gut...
May 12, 2018: Clinical Reviews in Allergy & Immunology
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