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https://www.readbyqxmd.com/read/28346501/a-tissue-specific-role-for-intraflagellar-transport-genes-during-craniofacial-development
#1
Elizabeth N Schock, Jaime N Struve, Ching-Fang Chang, Trevor J Williams, John Snedeker, Aria C Attia, Rolf W Stottmann, Samantha A Brugmann
Primary cilia are nearly ubiquitous, cellular projections that function to transduce molecular signals during development. Loss of functional primary cilia has a particularly profound effect on the developing craniofacial complex, causing several anomalies including craniosynostosis, micrognathia, midfacial dysplasia, cleft lip/palate and oral/dental defects. Development of the craniofacial complex is an intricate process that requires interactions between several different tissues including neural crest cells, neuroectoderm and surface ectoderm...
2017: PloS One
https://www.readbyqxmd.com/read/28343124/effects-of-acute-alcohol-consumption-on-measures-of-simulated-driving-a-systematic-review-and-meta-analysis
#2
Christopher Irwin, Elizaveta Iudakhina, Ben Desbrow, Danielle McCartney
Driving simulators are used in a wide range of research settings to help develop an understanding of driver behavior in complex environments. Acute alcohol impairment is an important research topic for traffic safety and a large number of studies have indicated levels of simulated driving impairment imposed by alcohol across a range of performance outcome variables. The aim of the present study was to examine the impact of acute alcohol consumption on simulated driving performance by conducting a systematic review and meta-analysis of the available evidence...
March 23, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28342334/oncogene-addiction-in-non-small-cell-lung-cancer-focus-on-ros1-inhibition
#3
REVIEW
Francesco Facchinetti, Giulio Rossi, Emilio Bria, Jean-Charles Soria, Benjamin Besse, Roberta Minari, Luc Friboulet, Marcello Tiseo
Detection of molecular aberrations driving the biology and the clinical behavior of advanced non-small cell lung cancer (NSCLC) allows the adoption of specific therapeutic strategies dramatically impacting disease courses. Among these, ROS1 rearrangements are present in 1-2% of lung adenocarcinomas. Thanks to similarities between ALK and ROS1 oncogenes, lessons inferred from ALK can be applied to ROS1-positive NSCLC; nevertheless, disparities exist between diseases mastered by these two fusion genes. In the absence of more common genetic alterations detected in NSCLC (e...
March 12, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28332869/perceived-enjoyment-concentration-intention-and-speed-violation-behavior-using-flow-theory-and-theory-of-planned-behavior
#4
Charles Atombo, Chaozhong Wu, Hui Zhang, Tina D Wemegah
OBJECTIVE: Road accidents are an important public health concern and speeding is a major contributor. Although, flow theory (FLT) is a valid model for understanding behavior, currently the nature of the roles and interplay, of FLT constructs within the theory of planned behavior (TPB) framework when attempting to explain the determinants of motivations for intention to speed and speeding behavior of car drivers is not yet known. The study aims to synthesize TPB and FLT in explaining drivers of advanced vehicles intention to speed and speed violation behavior and evaluate factors which are critical for explaining intention and behavior...
March 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28329645/frequent-somatic-mutations-of-chromatin-remodeling-genes-in-metastatic-cutaneous-squamous-cell-carcinoma
#5
Amanda Ewart Toland
Exome and targeted sequencing studies have identified potential driver mutations for a variety of tumor types. Cutaneous squamous cell carcinoma (cSCC) is one of the most highly mutated cancers but is typically correlated with high survival rates and low rates of metastasis. Nevertheless, metastatic cSCC is a significant health threat; up to 8800 individuals are estimated to die yearly from this disease. As it is difficult to predict which cSCCs are more likely to metastasize, and because there are no targeted therapies specifically designated for metastatic cSCC, we performed exome and targeted sequencing of 18 metastatic and 10 primary cSCCs to identify mutations with potential therapeutic benefit...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28323449/the-relative-importance-of-real-time-in-cab-and-external-feedback-in-managing-fatigue-in-real-world-commercial-transport-operations
#6
Michael Fitzharris, Sara Liu, Amanda N Stephens, Michael G Lenné
OBJECTIVE: Real-time driver monitoring systems represent a solution to address key behavioral risks as they occur, particularly distraction and fatigue. The efficacy of these systems in real-world settings is largely unknown. This paper has three objectives: 1) to document the incidence and duration of fatigue in real-world commercial truck driving operations, 2) to determine the reduction, if any, in the incidence of fatigue episodes associated with providing feedback, and 3) to tease apart the relative contribution of in-cab warnings from 24 monitoring and feedback to employers...
March 21, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28323444/evaluating-driver-drowsiness-countermeasures
#7
John G Gaspar, Timothy L Brown, Chris W Schwarz, John D Lee, Julie Kang, James S Higgins
Objective Driver drowsiness contributes to a substantial number of fatal and non-fatal crashes, with recent estimates attributing up to 21% of fatal crashes to drowsiness. This paper describes recent NHTSA research on in-vehicle drowsiness countermeasures. Recent advances in technology and state detection algorithms have shown success in detecting drowsiness using a variety of data sources, including camera-based eye tracking, steering wheel position, yaw rate, and vehicle lane position. However, detection is just the first step in reducing drowsy driving crashes...
March 21, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28319757/interaction-driver-bicyclist-on-rural-roads-effects-of-cross-sections-and-road-geometric-elements
#8
Francesco Bella, Manuel Silvestri
The interaction of motorists and bicyclists, particularly during passing maneuvers, is cited as one of the primary causes of bicyclist fatalities. This paper reports the results of a driving simulator study, which sought to analyze the effects that three cross-section configurations of a two-lane rural road and four geometric elements of the road have on driver behavior, during the interaction with a cyclist. A two-lane rural road, about 11km long, was designed and implemented in an advanced-interactive driving simulator...
March 17, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28315616/counterfactual-simulations-applied-to-shrp2-crashes-the-effect-of-driver-behavior-models-on-safety-benefit-estimations-of-intelligent-safety-systems
#9
Jonas Bärgman, Christian-Nils Boda, Marco Dozza
As the development and deployment of in-vehicle intelligent safety systems (ISS) for crash avoidance and mitigation have rapidly increased in the last decades, the need to evaluate their prospective safety benefits before introduction has never been higher. Counterfactual simulations using relevant mathematical models (for vehicle dynamics, sensors, the environment, ISS algorithms, and models of driver behavior) have been identified as having high potential. However, although most of these models are relatively mature, models of driver behavior in the critical seconds before a crash are still relatively immature...
March 15, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28303239/epidemiology-of-ebola-virus-disease-in-the-western-area-region-of-sierra-leone-2014-2015
#10
Margaret Lamunu, Olushayo Oluseun Olu, James Bangura, Zabulon Yoti, Thomas Takpau Samba, David Kabba Kargbo, Foday Mohamed Dafae, Muhammad Ali Raja, Noah Sempira, Michael Lyazi Ivan, Aarti Sing, Fredson Kurti-George, Negusu Worku, Pamela Mitula, Louisa Ganda, Robert Samupindi, Roland Conteh, Kande-Bure Kamara, Beatrice Muraguri, Michael Kposowa, Joseph Charles, Malimbo Mugaga, Christopher Dye, Anshu Banerjee, Pierre Formenty, Brima Kargbo, Raymond Bruce Aylward
INTRODUCTION: Western Area (WA) of Sierra Leone including the capital, Freetown, experienced an unprecedented outbreak of Ebola from 2014 to 2015. At the onset of the epidemic, there was little information about the epidemiology, transmission dynamics, and risk factors in urban settings as previous outbreaks were limited to rural/semi-rural settings. This study, therefore, aimed to describe the epidemiology of the outbreak and the factors which had most impact on the transmission of the epidemic and whether there were different drivers from those previously described in rural settings...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28301856/the-role-of-dietary-experience-in-the-development-of-eating-behavior-during-the-first-years-of-life
#11
Sophie Nicklaus
Infants are born equipped to ingest nutrients, but because of the transitions in the mode of feeding in the first years (from "tube" feeding in utero to eating table foods with the family), they have to learn how, what and how much to eat. Eating behavior established during early years may follow throughout childhood; therefore, it is fundamental to understand the most important drivers of the early development of eating behavior. Beyond the first flavor discoveries during the gestational and lactation periods (through the infant's exposure to flavors from foods of the mother's diet), the most important phases for learning food preferences and appetite control may be the beginning of complementary feeding (CF)...
March 17, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28299152/ebola-viral-disease-in-west-africa-a-threat-to-global-health-economy-and-political-stability
#12
Semeeh Akinwale Omoleke, Ibrahim Mohammed, Yauba Saidu
The West African sub-continent is currently experiencing its first, and ironically, the largest and longest Ebola viral diseases (EVD) outbreak ever documented in modern medical history. The current outbreak is significant in several ways, including longevity, magnitude of morbidity and mortality, occurrence outside the traditional niches, rapid spread and potential of becoming a global health tragedy. The authors provided explicit insights into the current and historical background, drivers of the epidemic, societal impacts, status of vaccines and drugs development and proffered recommendations to halt and prevent future occurrences...
August 17, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28297966/traffic-model-with-an-absorbing-state-phase-transition
#13
M L L Iannini, Ronald Dickman
We consider a modified Nagel-Schreckenberg (NS) model in which drivers do not decelerate if their speed is smaller than the headway (number of empty sites to the car ahead). (In the original NS model, such a reduction in speed occurs with probability p, independent of the headway, as long as the current speed is greater than zero.) In the modified model the free-flow state (with all vehicles traveling at the maximum speed, v_{max}) is absorbing for densities ρ smaller than a critical value ρ_{c}=1/(v_{max}+2)...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28295286/predicting-coastal-algal-blooms-in-southern-california
#14
John A McGowan, Ethan R Deyle, Hao Ye, Melissa L Carter, Charles T Perretti, Kerri D Seger, Alain de Verneil, George Sugihara
The irregular appearance of planktonic algae blooms off the coast of southern California has been a source of wonder for over a century. Although large algal blooms can have significant negative impacts on ecosystems and human health, a predictive understanding of these events has eluded science, and many have come to regard them as ultimately random phenomena. However, the highly nonlinear nature of ecological dynamics can give the appearance of randomness and stress traditional methods-such as model fitting or analysis of variance-to the point of breaking...
March 10, 2017: Ecology
https://www.readbyqxmd.com/read/28293047/personality-driving-behavior-and-mental-disorders-factors-as-predictors-of-road-traffic-accidents-based-on-logistic-regression
#15
Seyyed Salman Alavi, Mohammad Reza Mohammadi, Hamid Souri, Soroush Mohammadi Kalhori, Fereshteh Jannatifard, Ghazal Sepahbodi
BACKGROUND: The aim of this study was to evaluate the effect of variables such as personality traits, driving behavior and mental illness on road traffic accidents among the drivers with accidents and those without road crash. METHODS: In this cohort study, 800 bus and truck drivers were recruited. Participants were selected among drivers who referred to Imam Sajjad Hospital (Tehran, Iran) during 2013-2015. The Manchester driving behavior questionnaire (MDBQ), big five personality test (NEO personality inventory) and semi-structured interview (schizophrenia and affective disorders scale) were used...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28291460/validation-of-laboratory-animal-and-surrogate-human-models-in-primary-blast-injury-studies
#16
Namas Chandra, Aravind Sundaramurthy, Raj K Gupta
Blast-induced neurotrauma has affected more than 300,000 service members. It is important to understand the effect of single and repeated shock-blast wave exposures on the neuropsychological behavior of soldiers, to offer them better protection, diagnostics, and treatment. Preclinical animal models and helmet design studies on human surrogate models have relied on the use of compression gas-driven shock tubes. Traditional shock tubes are so simple that if not carefully designed and operated, the test results can easily introduce detrimental artifacts clouding the conclusions...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28287118/the-invasive-pest-drosophila-suzukii-uses-trans-generational-medication-to-resist-parasitoid-attack
#17
M Poyet, P Eslin, O Chabrerie, S M Prud'homme, E Desouhant, P Gibert
Animal medication is a behavioral strategy to resist enemies based on the use of substances from the environment. While it has been observed in several animals, whether invasive species can use medication to resist new enemies during its expansion is unknown. Here, we show that the worldwide invasive pest Drosophila suzukii performs trans-generational prophylactic medication by adapting its oviposition behavior in the presence of enemies. We find that flies preferentially lay their eggs on media containing atropine - an entomotoxic alkaloid - in the presence of parasitoids...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28285456/is-vf-an-ablatable-rhythm
#18
REVIEW
Ghassen Cheniti, Meleze Hocini, Ruairidh Martin, Frederic Sacher, Remi Dubois, Michel Haissaguerre, Pierre Jais
Ventricular fibrillation (VF) has traditionally been considered to be a disorganized arrhythmia not amenable to catheter ablation. However, a better understanding of the VF pathophysiology has allowed identification of targets for ablation. Ablation targeting the premature ventricular complexes which trigger VF was proven to be associated with high success rates and long-term freedom from VF recurrence. Recent mapping data has identified rotors, focal breakthroughs, and figure of eight re-entries as main drivers maintaining human VF...
February 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28282378/the-socio-economic-drivers-of-bushmeat-consumption-during-the-west-african-ebola-crisis
#19
Isabel Ordaz-Németh, Mimi Arandjelovic, Lukas Boesch, Tsegaye Gatiso, Trokon Grimes, Hjalmar S Kuehl, Menladi Lormie, Colleen Stephens, Clement Tweh, Jessica Junker
Bushmeat represents an important source of animal protein for humans in tropical Africa. Unsustainable bushmeat hunting is a major threat to wildlife and its consumption is associated with an increased risk of acquiring zoonotic diseases, such as Ebola virus disease (EVD). During the recent EVD outbreak in West Africa, it is likely that human dietary behavior and local attitudes toward bushmeat consumption changed in response to the crisis, and that the rate of change depended on prevailing socio-economic conditions, including wealth and education...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28278592/exploring-associations-between-self-regulatory-mechanisms-and-neuropsychological-functioning-and-driver-behaviour-after-brain-injury
#20
Per-Ola Rike, Hans J Johansen, Pål Ulleberg, Anna Lundqvist, Anne-Kristine Schanke
The objective of this prospective one-year follow-up study was to explore the associations between self-regulatory mechanisms and neuropsychological tests as well as baseline and follow-up ratings of driver behaviour. The participants were a cohort of subjects with stroke and traumatic brain injury (TBI) who were found fit to drive after a multi-disciplinary driver assessment (baseline). Baseline measures included neuropsychological tests and ratings of self-regulatory mechanisms, i.e., executive functions (Behavior Rating Inventory of Executive Function-Adult Version; BRIEF-A) and impulsive personality traits (UPPS Impulsive Behavior Scale)...
April 11, 2016: Neuropsychological Rehabilitation
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