keyword
MENU ▼
Read by QxMD icon Read
search

Human error

keyword
https://www.readbyqxmd.com/read/29223495/estimation-of-spinal-joint-centers-from-external-back-profile-and-anatomical-landmarks
#1
A Nerot, W Skalli, X Wang
Defining a subject-specific model of the human body is required for motion analysis in many fields, such as in ergonomics and clinical applications. However, locating internal joint centers from external characteristics of the body still remains a challenging issue, in particular for the spine. Current methods mostly require a set of rarely accessible (3D back or trunk surface) or operator dependent inputs (large number of palpated landmarks and landmarks-based anthropometrics). Therefore, there is a need to provide an alternative way to estimate joint centers only using a limited number of easily palpable landmarks and the external back profile...
November 20, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29223048/extraction-protocol-and-liquid-chromatography-tandem-mass-spectrometry-method-for-determining-micelle-entrapped-paclitaxel-at-the-cellular-and-subcellular-levels-application-to-a-cellular-uptake-and-distribution-study
#2
Nan Zheng, Bin Lian, Wenwen Du, Guobing Xu, Jiafu Ji
Paclitaxel-loaded polymeric micelles (PTX-PM) are commonly used as tumor-targeted nanocarriers and display outstanding antitumor features in clinic, but its accumulation and distribution in vitro are lack of investigation. It is probably due to the complex micellar system and its low concentration at the cellular or subcellular levels. In this study, we developed an improved extraction method, which was a combination of mechanical disruption and liquid-liquid extraction (LLE), to extract the total PTX from micelles in the cell lysate and subcellular compartments...
December 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29222462/a-translational-model-to-determine-rodent-s-age-from-human-foetal-age
#3
Yoshiyuki Ohmura, Yasuo Kuniyoshi
To understand the prenatal origin of developmental and psychiatric disorders, studies in laboratory animals are imperative. However, the developmental pace differs between humans and animals; hence, corresponding human ages must be estimated to infer the most vulnerable developmental timings in humans. Because rats and mice are extensively used as models in developmental research, a correspondence between human foetal ages and rodents' ages must be precisely determined; thus, developing a translational model is of utmost importance...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29220613/fully-automated-pipetting-sorting-system-for-different-morphological-phenotypes-of-zebrafish-embryos
#4
Helmut Breitwieser, Thomas Dickmeis, Marcel Vogt, Marco Ferg, Christian Pylatiuk
Systems biology methods, such as transcriptomics and metabolomics, require large numbers of small model organisms, such as zebrafish embryos. Manual separation of mutant embryos from wild-type embryos is a tedious and time-consuming task that is prone to errors, especially if there are variable phenotypes of a mutant. Here we describe a zebrafish embryo sorting system with two cameras and image processing based on template-matching algorithms. In order to evaluate the system, zebrafish rx3 mutants that lack eyes due to a patterning defect in brain development were separated from their wild-type siblings...
December 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/29220087/dual-energy-based-metal-segmentation-for-metal-artifact-reduction-in-dental-computed-tomography
#5
Mohamed A A Hegazy, Mohamed Elsayed Eldib, Daniel Hernandez, Myung Hye Cho, Min Hyoung Cho, Soo Yeol Lee
PURPOSE: In a dental CT scan, the presence of dental fillings or dental implants generates severe metal artifacts that often compromise readability of the CT images. Many metal artifact reduction (MAR) techniques have been introduced, but dental CT scans still suffer from severe metal artifacts particularly when multiple dental fillings or implants exist around the region of interest. The high attenuation coefficient of teeth often causes erroneous metal segmentation, compromising the MAR performance...
December 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/29218437/d-lactic-acidosis-in-humans-systematic-literature-review
#6
Davide G A M Bianchetti, Giacomo S Amelio, Sebastiano A G Lava, Mario G Bianchetti, Giacomo D Simonetti, Carlo Agostoni, Emilio F Fossali, Gregorio P Milani
BACKGROUND: D-lactic acidosis is an uncommon and challenging form of metabolic acidosis that may develop in short bowel syndrome. It has been documented exclusively in case reports and small case series. METHODS: We performed a review of the literature in the National Library of Medicine and Excerpta Medica databases. RESULTS: We identified 84 original reports published between 1977 and 2017. D-lactic acidosis was observed in 98 individuals ranging in age from 7 months to 86 years with short bowel syndrome...
December 7, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29218324/intellicount-high-throughput-quantification-of-fluorescent-synaptic-protein-puncta-by-machine-learning
#7
J A Fantuzzo, V R Mirabella, A H Hamod, R P Hart, J D Zahn, Z P Pang
Synapse formation analyses can be performed by imaging and quantifying fluorescent signals of synaptic markers. Traditionally, these analyses are done using simple or multiple thresholding and segmentation approaches or by labor-intensive manual analysis by a human observer. Here, we describe Intellicount, a high-throughput, fully-automated synapse quantification program which applies a novel machine learning (ML)-based image processing algorithm to systematically improve region of interest (ROI) identification over simple thresholding techniques...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29215633/measuring-mutation-accumulation-in-single-human-adult-stem-cells-by-whole-genome-sequencing-of-organoid-cultures
#8
Myrthe Jager, Francis Blokzijl, Valentina Sasselli, Sander Boymans, Roel Janssen, Nicolle Besselink, Hans Clevers, Ruben van Boxtel, Edwin Cuppen
Characterization of mutational processes in adult stem cells (ASCs) will improve our understanding of aging-related diseases, such as cancer and organ failure, and may ultimately help prevent the development of these diseases. Here, we present a method for cataloging mutations in individual human ASCs without the necessity of using error-prone whole-genome amplification. Single ASCs are expanded in vitro into clonal organoid cultures to generate sufficient DNA for accurate whole-genome sequencing (WGS) analysis...
January 2018: Nature Protocols
https://www.readbyqxmd.com/read/29215082/the-myokinetic-control-interface-tracking-implanted-magnets-as-a-means-for-prosthetic-control
#9
S Tarantino, F Clemente, D Barone, M Controzzi, C Cipriani
Upper limb amputation deprives individuals of their innate ability to manipulate objects. Such disability can be restored with a robotic prosthesis linked to the brain by a human-machine interface (HMI) capable of decoding voluntary intentions, and sending motor commands to the prosthesis. Clinical or research HMIs rely on the interpretation of electrophysiological signals recorded from the muscles. However, the quest for an HMI that allows for arbitrary and physiologically appropriate control of dexterous prostheses, is far from being completed...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214516/advances-in-stereotactic-navigation-for-pelvic-surgery
#10
A R Wijsmuller, L G C Romagnolo, V Agnus, C Giraudeau, A G F Melani, B Dallemagne, J Marescaux
BACKGROUND: Stereotactic navigation could improve the quality of surgery for rectal cancer. Critical challenges related to soft tissue stereotactic pelvic navigation include the potential difference in patient anatomy between intraoperative lithotomy and preoperative supine position for imaging. The objective of this study was to determine the difference in patient anatomy, sacral tilt, and skin fiducial position between these different patient positions and to investigate the feasibility and optimal set-up for stereotactic pelvic navigation...
December 6, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29214031/parp-inhibitors-as-potential-therapeutic-agents-for-various-cancers-focus-on-niraparib-and-its-first-global-approval-for-maintenance-therapy-of-gynecologic-cancers
#11
REVIEW
Mekonnen Sisay, Dumessa Edessa
Poly (ADP-ribose) polymerases (PARPs) are an important family of nucleoproteins highly implicated in DNA damage repair. Among the PARP families, the most studied are PARP1, PARP2 and PARP 3. PARP1 is found to be the most abundant nuclear enzyme under the PARP series. These enzymes are primarily involved in base excision repair as one of the major single strand break (SSB) repair mechanisms. Being double stranded, DNA engages itself in reparation of a sub-lethal SSB with the aid of PARP. Moreover, by having a sister chromatid, DNA can also repair double strand breaks with either error-free homologous recombination or error-prone non-homologous end-joining...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/29210081/improvement-of-monoclonal-antibody-immobilized-granulocyte-antigen-assay-for-the-detection-of-anti-hna-1-alloantibodies
#12
Piyapong Simtong, Amornrat V Romphruk, Christine Hofmann, Angelika Reil, Ulrich J Sachs, Sentot Santoso
BACKGROUND: Currently, the gold standard for the identification of antibodies against human neutrophil antigens (HNAs) is the monoclonal antibody-immobilized granulocyte antigen (MAIGA) assay. However, the handling of this assay is laborious and therefore cumbersome for the rapid screening of neutrophil antibodies. STUDY DESIGN AND METHODS: In this study, we simplified the performance of the conventional MAIGA procedure and approved it for the identification of anti-HNA-1 with HNA-1-typed neutrophils and stable transfected (HEK293) cell line expressing HNA-1a, -1b, and -1c...
December 6, 2017: Transfusion
https://www.readbyqxmd.com/read/29209930/a-psychometric-validation-of-the-employers-stigmatizing-attitudes-toward-cancer-survivors-scale
#13
Wei-Mo Tu, Joseph Pfaller, Kanako Iwanaga, Fong Chan, David Strauser, Ming-Hung Wang, Nicole Ditchman
Purpose The aim of this study was to evaluate the measurement structure of the Employers' Stigmatizing Attitudes Toward Cancer Survivors Scale (ESATPD-Cancer Scale). Methods A quantitative descriptive design using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). One hundred and seventy-seven Taiwanese human resources (HR) professionals participated in this study. Results EFA revealed a one-factor measurement structure accounting for 50% of the total variance. We conducted a CFA to confirm the one-factor structure; after two pairs of error terms were correlated, the re-specified model was found to fit the data adequately: χ2/df = 1...
December 5, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/29208708/aminoglycoside-interactions-and-impacts-on-the-eukaryotic-ribosome
#14
Irina Prokhorova, Roger B Altman, Muminjon Djumagulov, Jaya P Shrestha, Alexandre Urzhumtsev, Angelica Ferguson, Cheng-Wei Tom Chang, Marat Yusupov, Scott C Blanchard, Gulnara Yusupova
Aminoglycosides are chemically diverse, broad-spectrum antibiotics that target functional centers within the bacterial ribosome to impact all four principle stages (initiation, elongation, termination, and recycling) of the translation mechanism. The propensity of aminoglycosides to induce miscoding errors that suppress the termination of protein synthesis supports their potential as therapeutic interventions in human diseases associated with premature termination codons (PTCs). However, the sites of interaction of aminoglycosides with the eukaryotic ribosome and their modes of action in eukaryotic translation remain largely unexplored...
December 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29207494/an-opportunistic-pathogen-afforded-ample-opportunities-middle-east-respiratory-syndrome-coronavirus
#15
REVIEW
Ian M Mackay, Katherine E Arden
The human coronaviruses (CoV) include HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1, some of which have been known for decades. The severe acute respiratory syndrome (SARS) CoV briefly emerged into the human population but was controlled. In 2012, another novel severely human pathogenic CoV-the Middle East Respiratory Syndrome (MERS)-CoV-was identified in the Kingdom of Saudi Arabia; 80% of over 2000 human cases have been recorded over five years. Targeted research remains key to developing control strategies for MERS-CoV, a cause of mild illness in its camel reservoir...
December 2, 2017: Viruses
https://www.readbyqxmd.com/read/29202438/spatial-resolved-dual-signal-output-electrochemiluminescent-ratiometric-strategy-for-accurate-and-sensitive-immunoassay
#16
Yu-Ling Wang, Fu-Rao Liu, Jun-Tao Cao, Shu-Wei Ren, Yan-Ming Liu
The identification of tumor markers is of great importance for clinical diagnosis but accurate detection with high sensitivity is still a great challenge. In present work, a spatial-resolved dual-signal-output electrochemiluminescent (ECL) ratiometric assay platform was constructed for sensitive detection of prostate specific antigen (PSA) on a dual-disk glassy carbon electrode. To fabricate the platform, flower-like CdS three-dimensional (3D) assemblies and Ru(bpy)32+-conjugated silica nanoparticles (Ru(bpy)32+@RuSi NPs), were immobilized onto the two disks as cathodic and anodic ECL emitters, respectively...
December 1, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29202388/comparison-of-three-way-and-four-way-calibration-for-the-real-time-quantitative-analysis-of-drug-hydrolysis-in-complex-dynamic-samples-by-excitation-emission-matrix-fluorescence
#17
Xiao-Li Yin, Hui-Wen Gu, Xiao-Lu Liu, Shan-Hui Zhang, Hai-Long Wu
Multiway calibration in combination with spectroscopic technique is an attractive tool for online or real-time monitoring of target analyte(s) in complex samples. However, how to choose a suitable multiway calibration method for the resolution of spectroscopic-kinetic data is a troubling problem in practical application. In this work, for the first time, three-way and four-way fluorescence-kinetic data arrays were generated during the real-time monitoring of the hydrolysis of irinotecan (CPT-11) in human plasma by excitation-emission matrix fluorescence...
November 23, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29201074/worldwide-recall-rate-in-newborn-screening-programs-for-congenital-hypothyroidism
#18
REVIEW
Ladan Mehran, Davood Khalili, Shahin Yarahmadi, Atieh Amouzegar, Mehdi Mojarrad, Nasrin Ajang, Fereidoun Azizi
Context: Neonatal mass screening program for congenital hypothyroidism provides the best tool for prevention of its devastating effects on mental development. Despite the overall success of the screening programs in detecting congenital hypothyroidism and eliminating its sequelae and new developments made in the program design, high recall rate and false positive results impose a great challenge worldwide. Lower recall rate and false positive results may properly organize project expenses by reducing the unnecessary repeated laboratory tests, increase physicians and parents' assurance and cooperation, as well as reduce the psychological effects in families...
July 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29200069/visualization-improves-supraclavicular-access-to-the-subclavian-vein-in-a-mixed-reality-simulator
#19
Joshua Warren Sappenfield, William Brit Smith, Lou Ann Cooper, David Lizdas, Drew B Gonsalves, Nikolaus Gravenstein, Samsun Lampotang, Albert R Robinson
BACKGROUND: We investigated whether visual augmentation (3D, real-time, color visualization) of a procedural simulator improved performance during training in the supraclavicular approach to the subclavian vein, not as widely known or used as its infraclavicular counterpart. METHODS: To train anesthesiology residents to access a central vein, a mixed reality simulator with emulated ultrasound imaging was created using an anatomically authentic, 3D-printed, physical mannequin based on a computed tomographic scan of an actual human...
November 30, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29197390/evaluation-of-b1-inhomogeneity-effect-on-dce-mri-data-analysis-of-brain-tumor-patients-at-3t
#20
Anirban Sengupta, Rakesh Kumar Gupta, Anup Singh
BACKGROUND: Dynamic-contrast-enhanced (DCE) MRI data acquired using gradient echo based sequences is affected by errors in flip angle (FA) due to transmit B1 inhomogeneity (B1inh). The purpose of the study was to evaluate the effect of B1inh on quantitative analysis of DCE-MRI data of human brain tumor patients and to evaluate the clinical significance of B1inh correction of perfusion parameters (PPs) on tumor grading. METHODS: An MRI study was conducted on 35 glioma patients at 3T...
December 2, 2017: Journal of Translational Medicine
keyword
keyword
23453
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"