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https://www.readbyqxmd.com/read/28915873/a-prospective-cohort-study-on-ambient-air-pollution-and-respiratory-morbidities-including-childhood-asthma-in-adolescents-from-the-western-cape-province-study-protocol
#1
Toyib Olaniyan, Mohamed Jeebhay, Martin Röösli, Rajen Naidoo, Roslynn Baatjies, Nino Künzil, Ming Tsai, Mark Davey, Kees de Hoogh, Dilys Berman, Bhawoodien Parker, Joy Leaner, Mohamed Aqiel Dalvie
BACKGROUND: There is evidence from existing literature that ambient air pollutant exposure in early childhood likely plays an important role in asthma exacerbation and other respiratory symptoms, with greater effect among asthmatic children. However, there is inconclusive evidence on the role of ambient air pollutant exposures in relation to increasing asthma prevalence as well as asthma induction in children. At the population level, little is known about the potential synergistic effects between pollen allergens and air pollutants since this type of association poses challenges in uncontrolled real life settings...
September 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28913990/association-between-sensitization-to-mold-and-impaired-pulmonary-function-in-children-with-asthma
#2
Jung Hye Byeon, Soohyun Ri, Oyuntulga Amarsaikhan, Eunji Kim, So Hyun Ahn, Ic Sun Choi, Hyung Jin Kim, SungChul Seo, Wonsuck Yoon, Young Yoo
PURPOSE: Recent data indicate that sensitization to mold contributes to the severity and persistence of asthma. In this study, we investigated the relationships between sensitization to mold and lung function parameters in children with asthma. METHODS: We retrospectively reviewed clinical data from 551 asthmatic subjects. We selected subjects who met clinical diagnostic criteria of asthma. Their spirometry, methacholine challenge tests, and measurements of blood eosinophils, serum IgE, eosinophil cationic protein (ECP) and fractional exhaled nitric oxide (FeNO) results were included...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28906034/small-airway-disease-a-different-phenotype-of-early-stage-copd-associated-with-biomass-smoke-exposure
#3
Dongxing Zhao, Yumin Zhou, Changbin Jiang, Zhuxiang Zhao, Fang He, Pixin Ran
BACKGROUND AND OBJECTIVE: Chronic exposure to biomass smoke (BS) can significantly compromise pulmonary function and lead to chronic obstructive pulmonary disease (COPD). To determine whether BS exposure induces a unique phenotype of COPD from an early stage, with different physiopathological features compared with COPD associated with smoking (cigarette-smoke (CS) COPD), we assessed the physiopathology of early COPD associated with BS exposure (BS COPD) by incorporating spirometry, high-resolution computed tomography (HRCT) imaging, bronchoscopy and pathological examinations...
September 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28902960/the-prognostic-significance-of-lung-function-in-stable-heart-failure-outpatients
#4
Louis Lind Plesner, Morten Dalsgaard, Morten Schou, Lars Køber, Jørgen Vestbo, Erik Kjøller, Kasper Iversen
BACKGROUND: This study investigated the impact on all-cause mortality of airflow limitation indicative of chronic obstructive pulmonary disease or restrictive spirometry pattern (RSP) in a stable systolic heart failure population. HYPOTHESIS: Decreased lung function indicates poor survival in heart failure. METHODS: Inclusion criteria: NYHA class II-IV and left ventricular ejection fraction (LVEF) < 45%. Prognosis was assessed with multivariate Cox proportional hazards models...
September 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28902919/factors-associated-with-pulmonary-impairment-in-hiv-infected-south-african-adults
#5
Akshay N Gupte, Michelle L Wong, Reginah Msandiwa, Grace L Barnes, Jonathan Golub, Richard E Chaisson, Christopher J Hoffmann, Neil A Martinson
BACKGROUND: HIV-infected individuals have increased risk of developing obstructive lung disease (OLD). Studies from developed countries report high viral load, low CD4 counts, and anti-retroviral therapy (ART) to be associated with OLD; but these findings may not be generalizable to populations in resource-limited settings. METHODS: We conducted a prospective cohort study of lung function in 730 HIV-infected black South African adults. Pre-bronchodilator spirometry was performed at enrollment and repeated annually for three years...
2017: PloS One
https://www.readbyqxmd.com/read/28895752/airflow-obstruction-and-use-of-solid-fuels-for-cooking-or-heating-bold-results
#6
André F S Amaral, Jaymini Patel, Bernet S Kato, Daniel O Obaseki, Hervé Lawin, Wan C Tan, Sanjay K Juvekar, Imed Harrabi, Michael Studnicka, Emiel F M Wouters, Li-Cher Loh, Eric D Bateman, Kevin Mortimer, A Sonia Buist, Peter G J Burney
RATIONALE: Evidence supporting the association of COPD or airflow obstruction with use of solid fuels is conflicting and inconsistent. OBJECTIVE: To assess the association of airflow obstruction with self-reported use of solid fuels for cooking or heating. METHODS: We analysed 18,554 adults from the BOLD study, who had provided acceptable post-bronchodilator spirometry measurements and information on use of solid fuels. The association of airflow obstruction with use of solid fuels for cooking or heating was assessed by sex, within each site, using regression analysis...
September 12, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28893868/official-ers-technical-standards-global-lung-function-initiative-reference-values-for-the-carbon-monoxide-transfer-factor-for-caucasians
#7
Sanja Stanojevic, Brian L Graham, Brendan G Cooper, Bruce R Thompson, Kim W Carter, Richard W Francis, Graham L Hall
There are numerous reference equations available for the single-breath transfer factor of the lung for carbon monoxide (T LCO); however, it is not always clear which reference set should be used in clinical practice. The aim of the study was to develop the Global Lung Function Initiative (GLI) all-age reference values for T LCOData from 19 centres in 14 countries were collected to define T LCO reference values. Similar to the GLI spirometry project, reference values were derived using the LMS (lambda, mu, sigma) method and the GAMLSS (generalised additive models for location, scale and shape) programme in R...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28892559/spirometry-adjusted-exhaled-nitric-oxide-increases-accuracy-for-assessment-of-asthma-control-in-children
#8
Carla Martins, Diana Silva, Milton Severo, João Rufo, Inês Paciência, Joana Madureira, Patrícia Padrão, Pedro Moreira, Luís Delgado, Eduardo Oliveira Fernandes, Henrique Barros, Pekka Malmberg, André Moreira
Spirometry and exhaled nitric oxide are two important complimentary tools to identify and assess asthma control in children. We aimed to determine the ability of a new suggested spirometry adjusted exhaled nitric oxide (NO) index in doing that. A random sample of 1602 schoolchildren were screened by a health questionnaire, skin-prick tests, spirometry with bronchodilation and exhaled NO. A total of 662 children were included with median (IQR) exhaled NO 11(14) ppb. ROC curves using exhaled NO equations from Malmberg, Kovesi and Buchvald, and spirometry adjusted exhaled NO values were applied to identify asthmatic children and uncontrolled asthma...
September 11, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28892548/pediatric-obstructive-sleep-apnea-and-asthma-clinical-implications
#9
Michelle Trivedi, Mai El Mallah, Evan Bailey, Ted Kremer, Lawrence M Rhein
Obstructive sleep apnea (OSA) and asthma are common conditions in children with preventable long-term consequences. There is significant overlap in symptomatology and pathophysiology for pediatric OSA and asthma. Recent evidence supports clear associations between the two diseases; however, causality has not been demonstrated. Regardless, it is important to recognize the overlap and evaluate for the other condition when one is present. For example, in patients with severe OSA, clinical evaluation for asthma should be considered, including history for typical asthma symptoms and spirometry...
September 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28891543/a-survey-of-asthma-management-practices-and-implementation-of-global-initiative-for-asthma-guidelines-among-doctors-in-a-resource-limited-setting-in-nigeria
#10
E I Chima, M O Iroezindu, N R Uchenna, G O Mbata, C G Okwuonu
BACKGROUND: Bronchial asthma is a global health problem that causes significant morbidity and mortality in all age groups. Global Initiative for Asthma (GINA) seeks to standardize the care asthma patients receive. We assessed the knowledge, attitude, and practices of doctors in Umuahia, Southeast Nigeria, regarding asthma and determined the extent to which they abide by GINA guidelines in their management of asthma. METHODOLOGY: It was a descriptive cross-sectional study...
August 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28888846/diagnostic-accuracy-of-urinary-lte4-measurement-to-predict-aspirin-exacerbated-respiratory-disease-in-patients-with-asthma
#11
Grazyna Bochenek, Tomasz Stachura, Krystyna Szafraniec, Hanna Plutecka, Marek Sanak, Ewa Nizankowska-Mogilnicka, Krzysztof Sladek
BACKGROUND: Patients with aspirin-exacerbated respiratory disease (AERD) are distinguished from patients with aspirin-tolerant asthma (ATA) by significantly higher baseline concentrations of urinary leukotriene E4 (uLTE4). However, an overlap between the individual values of the groups exists. OBJECTIVE: The objective of this study was to estimate the discriminative value of uLTE4 concentration in differentiating between patients with AERD and patients with ATA and evaluate the diagnostic accuracy of uLTE4 measurement alone and added to clinical parameters to predict AERD diagnosis in patients with asthma...
September 6, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28887505/impaired-fibrinolysis-and-lower-levels-of-plasma-%C3%AE-2-macroglobulin-are-associated-with-an-increased-risk-of-severe-asthma-exacerbations
#12
Stanislawa Bazan-Socha, Lucyna Mastalerz, Agnieszka Cybulska, Lech Zareba, Romy Kremers, Michal Zabczyk, Grazyna Pulka, Teresa Iwaniec, Jan G Bazan, Coenraad Hemker, Anetta Undas
Recently we have reported that asthma is associated with enhanced plasma thrombin formation, impaired fibrinolysis and platelet activation. In the present study we investigated whether described prothrombotic blood alterations might predispose to thromboembolic events or asthma exacerbations. In 164 adult asthmatics we assessed clinical events during 3-year follow-up and analyzed their associations with measured at baseline prothrombotic blood parameters. Data were obtained from 157 (95.7%) of the asthma patients...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886594/elemental-sulfur-use-and-associations-with-pediatric-lung-function-and-respiratory-symptoms-in-an-agricultural-community-california-usa
#13
Rachel Raanan, Robert B Gunier, John R Balmes, Alyssa J Beltran, Kim G Harley, Asa Bradman, Brenda Eskenazi
BACKGROUND: Elemental sulfur, "the oldest of all pesticides," is the most heavily used agricultural pesticide in California and Europe. Sulfur is considered relatively safe and is used in both conventional and organic farming systems. Adverse respiratory effects have been reported in applicators and animals, but the effect on residential populations, and especially on children living in proximity to fields treated with elemental sulfur, is not known. OBJECTIVES: We evaluated associations between residential proximity to elemental sulfur applications and respiratory symptoms and spirometry of children living in an agricultural community...
August 10, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28886252/total-airway-count-on-computed-tomography-and-the-risk-of-copd-progression-findings-from-a-population-based-study
#14
Miranda Kirby, Naoya Tanabe, Wan C Tan, Guohai Zhou, Ma'en Obeidat, Cameron J Hague, Jonathon Leipsic, Jean Bourbeau, Don D Sin, James C Hogg, Harvey O Coxson
RATIONALE: Studies of excised lungs show that significant airway attrition in the 'quiet' zone occurs early in chronic obstructive pulmonary disease (COPD). OBJECTIVES: To determine if the total number of airways quantified in vivo using computed tomography (CT) reflects early airway-related disease changes and is associated with lung-function decline independent of emphysema in COPD. METHODS: Participants in the multi-centre, population-based, longitudinal CanCOLD study underwent inspiratory/expiratory CT at visit-1; spirometry was performed at four visits over 6-years...
September 8, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28886040/residual-volume-total-lung-capacity-ratio-confers-limited-additive-significance-to-lung-clearance-index-for-assessment-of-adults-with-bronchiectasis
#15
Wei-Jie Guan, Jing-Jing Yuan, Yan Huang, Hui-Min Li, Rong-Chang Chen, Nan-Shan Zhong
BACKGROUND: Mosaicism and hyperinflation are common pathophysiologic features of bronchiectasis. The magnitude of ventilation heterogeneity might have been affected by the degree of hyperinflation. Some studies have evaluated the discriminative performance of lung clearance index (LCI) in bronchiectasis patients, but the additive diagnostic value of hyperinflation metrics to LCI is unknown. OBJECTIVE: To compare LCI and the ratio of residual volume to total lung capacity (RV/TLC), along with the LCI normalized with RV/TLC, in terms of discriminative performance, correlation and concordance with clinical variables in adults with bronchiectasis...
2017: PloS One
https://www.readbyqxmd.com/read/28885968/diagnosing-chronic-obstructive-pulmonary-disease-among-afghanistan-and-iraq-veterans-veterans-affair-s-concordance-with-clinical-guidelines-for-spirometry-administration
#16
Aaron I Schneiderman, Deborah D Dougherty, Vincent P Fonseca, Charles L Wolters, Robert M Bossarte, Mehrdad Arjomandi
BACKGROUND: Early diagnosis and treatment of chronic obstructive pulmonary disease (COPD) can slow disease progression. The Department of Veterans Affairs (VA)/Department of Defense Clinical Practice Guidelines (CPG), established to improve patient outcomes, recommend the use of spirometry in the COPD diagnostic process. The aims of this study were to assess VA health care providers' performance related to CPG-recommended spirometry administration in the evaluation of newly diagnosed COPD among veterans, determine the patient characteristics that may influence the adherence rate, and compare VA concordance rates to those of other health plans...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28884732/-the-rehabilitative-treatment-of-the-patients-presenting-with-chronic-obstructive-pulmonary-disease-including-the-application-of-the-manual-handling-methods
#17
N S Ayrapetova, M A Eremushkin, I V Antonovich, O F Kuznetsov, A E Samorukov, S P Budylin, L Yu Tarasova, N A Derevnina
AIM: The objective of the present study was to identify the peculiar features and advantages of different methods for the mechanical impact on the thoracic tissues of the patients presenting with chronic obstructive pulmonary disease (COPD) and to develop specific indications for their clinical applications. MATERIAL AND METHODS: This randomized prospective comparative study included 137 patients with COPD. In accordance with the currently accepted classification (GOLD, 2013), all the patients had COPD of medium severity...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28883469/characteristics-of-newly-diagnosed-copd-patients-treated-with-triple-inhaled-therapy-by-general-practitioners-a-real-world-italian-study
#18
Fabiano Di Marco, Pierachille Santus, Silvia Terraneo, Elena Peruzzi, Elisa Muscianisi, Claudio Ripellino, Valeria Pegoraro
Factors predicting prescriptions of triple therapy were investigated in a large group of general practitioners in Italy. In the population treated by identified general practitioners, a cohort of newly diagnosed chronic obstructive pulmonary disease patients was extracted from IMS Health Longitudinal Database during the period 2010-2013. From the diagnosis, 1-year follow-up was evaluated. Thirty-two thousand forty-six newly diagnosed chronic obstructive pulmonary disease patients were evaluated (57.7% male, mean age 67 years)...
September 7, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28882651/in-cystic-fibrosis-lung-clearance-index-is-sensitive-to-detecting-abnormalities-appearing-at-exercise-in-children-with-normal-spirometry
#19
Riyadh Chelabi, Thibaud Soumagne, Alicia Guillien, Marc Puyraveau, Bruno Degano
Symptom-limited incremental cardiopulmonary exercise test was performed in school-age children with clinically stable cystic fibrosis (CF), all with normal spirometry. Physiological parameters were compared between patients with normal lung clearance index (LCI; n=6) and patients with elevated LCI (n=6). Dyspnoea ratings during exercise were similar in both groups. Although no patient had significant dynamic hyperinflation, end-expiratory lung volumes were higher throughout exercise in patients with elevated LCI...
September 4, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28882120/clinical-and-radiological-characteristics-of-patients-with-late-onset-severe-restrictive-lung-defect-after-hematopoietic-stem-cell-transplantation
#20
Ho Namkoong, Makoto Ishii, Takehiko Mori, Hiroaki Sugiura, Sadatomo Tasaka, Masatoshi Sakurai, Yuya Koda, Jun Kato, Naoki Hasegawa, Shinichiro Okamoto, Tomoko Betsuyaku
BACKGROUND: Late-onset noninfectious pulmonary complications (LONIPCs), which occur more than 3 months after allogeneic hematopoietic stem cell transplantation (HSCT), are major causes of morbidity and mortality after transplantation. Among LONIPCs, we occasionally treat patients with late-onset severe restrictive lung defect after HSCT; however, its clinical features have not been fully elucidated. METHODS: A retrospective chart review of a single center on cases of late-onset severe restrictive lung defect after HSCT was performed...
September 7, 2017: BMC Pulmonary Medicine
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