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Spirometry

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https://www.readbyqxmd.com/read/28087053/six-minute-walk-test-results-predict-risk-of-hospitalization-for-youths-with-cystic-fibrosis-a-5-year-follow-up-study
#1
Márcio V F Donadio, João P Heinzmann-Filho, Fernanda M Vendrusculo, Patrícia X H Frasson, Paulo J C Marostica
OBJECTIVE: To evaluate the association of 6-minute walk test (6MWT) and other variables (anthropometry, chronic Pseudomonas aeroginosa colonization, pulmonary function, and respiratory muscle strength) with the risk of hospitalization for pulmonary exacerbation in children and adolescents with cystic fibrosis (CF). STUDY DESIGN: Cohort study that included patients with CF aged 6-18 years. All participants underwent spirometry, manovacuometry, and 6MWT during the 5-year follow-up...
January 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28077140/indacaterol-and-glycopyrronium-versus-indacaterol-on-body-plethysmography-measurements-in-copd-a-randomised-controlled-study
#2
Joerg Salomon, Daiana Stolz, Guido Domenighetti, Jean-Georges Frey, Alexander J Turk, Andrea Azzola, Thomas Sigrist, Jean-William Fitting, Ulrich Schmidt, Thomas Geiser, Corinne Wild, Konstantinos Kostikas, Andreas Clemens, Martin Brutsche
BACKGROUND: Dual bronchodilator therapy is recommended for symptomatic patients with chronic obstructive pulmonary disease (COPD). There are limited data on effects of a combination of two long-acting bronchodilators on lung function including body plethysmography. METHODS: This multicentre, randomised, double-blind, single-dose, cross-over, placebo-controlled study evaluated efficacy and safety of the free combination of indacaterol maleate (IND) and glycopyrronium bromide (GLY) versus IND alone on spirometric and body plethysmography parameters, including inspiratory capacity (IC), forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity (TLC) and airway resistance (Raw) in moderate-to-severe COPD patients...
January 11, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28076945/effect-of-body-mass-index-on-pulmonary-function-in-children
#3
G Liyanage, B D Jayamanne, M Aaqiff, D Sriwardhana
Introduction: The relationship between obesity or overweight and pulmonary functions has not been investigated in Sri Lankan children previously. Therefore, we aimed to study the effects of obesity/overweight on dynamic lung functions in healthy school children in Sri Lanka. Methods: HASH(0x3887b88) Results: Of 275 children 55 (20%) were ‘obese/ overweight’. BMI has no significant relationship to any of the pulmonary function parameters...
30, 2016: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28076701/reduced-expiratory-flow-rate-among-heavy-smokers-increases-lung-cancer-risk-results-from-the-nlst-acrin-cohort-n-18-714
#4
Raewyn J Hopkins, Fenghai Duan, Caroline Chiles, Erin M Greco, Greg D Gamble, Denise Aberle, Robert P Young
RATIONALE: While epidemiological studies consistently show that chronic obstructive pulmonary disease (COPD) is associated with an increased risk of lung cancer, debate exists as to whether there is a linear relationship between the severity of airflow limitation and lung cancer risk. OBJECTIVES: We examined this in a large prospective study of older heavy smokers from the American College of Radiology Imaging Network sub-cohort of the National Lung Screening Trial (NLST-ACRIN)...
January 11, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28076530/factors-associated-with-chronic-obstructive-pulmonary-disease-among-the-elderly
#5
Ana Teresa Fernandes Barbosa, Jair Almeida Carneiro, Gizele Carmen Fagundes Ramos, Maísa Tavares Leite, Antônio Prates Caldeira
This study aimed to identify factors associated with Chronic Obstructive Pulmonary Disease (COPD) among non-institutionalized elderly people. It involved a cross-sectional study conducted on the basis of a household survey, followed by spirometry. People diagnosed with COPD were compared with those with normal spirometry, through bivariate analysis, followed by multivariate regression analysis. We identified 53 elderly people were identified with COPD. After multivariate analysis, the following factors associated with COPD were identified: past or current smoking (OR: 3...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28075609/female-smokers-are-at-greater-risk-of-airflow-obstruction-than-male-smokers-uk-biobank
#6
André F S Amaral, David P Strachan, Peter Gj Burney, Deborah L Jarvis
The prevalence of chronic obstructive pulmonary disease (COPD) is increasing faster among women than among men. <br><br> Objectives: To examine sex differences in the risk of airflow obstruction (COPD hallmark) in relation to smoking history. <br><br> Methods: We analysed 149,075 women and 100,252 men taking part in the UK Biobank, who had provided spirometry measurements and information on smoking. The association of airflow obstruction with smoking characteristics was assessed, by sex, using regression analysis...
January 11, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28065396/inhaled-corticosteroid-dose-response-in-asthma-should-we-measure-inflammation
#7
William J Anderson, Philip M Short, Sunny Jabbal, Brian J Lipworth
BACKGROUND: Inhaled corticosteroid (ICS) titration in asthma is primarily based on symptoms and pulmonary function. ICSs may not be increased on this basis despite residual airway inflammation. OBJECTIVE: To compare the dose-response relationships of ICSs on measures of pulmonary function, symptoms, and inflammation in patients with persistent asthma. METHODS: We performed a pooled post hoc analysis of 121 patients with mild to moderate asthma from 4 randomized clinical trials that incorporated an ICS dose ramp...
January 3, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28061834/prevalence-of-airflow-obstruction-in-patients-with-stable-systolic-heart-failure
#8
Morten Dalsgaard, Louis Lind Plesner, Morten Schou, Erik Kjøller, Jørgen Vestbo, Kasper Iversen
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an important differential diagnosis in heart failure (HF). However, routine use of spirometry in outpatient HF clinics is not implemented. The aim of the present study was to determine the prevalence of both airflow obstruction and non obstructive lung function impairment in patients with HF and to examine the effect of optimal medical treatment for HF on lung function parameters. METHODS: Consecutive patients with HF (ejection fraction (EF) < 45%) and New York Heart Association (NYHA) functional class II-IV at 10 different outpatient heart failure clinics were examined with spirometry at their first visit and after optimal medical treatment for HF was achieved...
January 6, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28057838/temporal-evolution-of-thoracocentesis-induced-changes-in-spirometry-and-respiratory-muscle-pressures
#9
Stylianos A Michaelides, George D Bablekos, Antonis Analitis, George Ionas, Petros Bakakos, Konstantinos A Charalabopoulos
BACKGROUND: Several studies investigated the effects of thoracocentesis on aspects of respiratory function without generally ensuring absence of coexistent lung pathology or homogeneity in initial size of the effusion. METHODS: We studied 90 patients aged 61.6±15.9 years (mean±SD) separated into a group A with small-sized or medium-sized effusion (A=56 patients) and a group B with large and massive one (B=34 patients). There was no significant lung lesion or cardiovascular pathology...
January 5, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28056984/the-main-rhinovirus-respiratory-tract-adhesion-site-icam-1-is-upregulated-in-smokers-and-patients-with-chronic-airflow-limitation-cal
#10
Shakti Dhar Shukla, Malik Quasir Mahmood, Steven Weston, Roger Latham, Hans Konrad Muller, Sukhwinder Singh Sohal, Eugene Haydn Walters
BACKGROUND: ICAM-1 is a major receptor for ~60% of human rhinoviruses, and non-typeable Haemophilus influenzae, two major pathogens in COPD. Increased cell-surface expression of ICAM-1 in response to tobacco smoke exposure has been suggested. We have investigated epithelial ICAM-1 expression in both the large and small airways, and lung parenchyma in smoking-related chronic airflow limitation (CAL) patients. METHODS: We evaluated epithelial ICAM-1 expression in resected lung tissue: 8 smokers with normal spirometry (NLFS); 29 CAL patients (10 small-airway disease; 9 COPD-smokers; 10 COPD ex-smokers); Controls (NC): 15 normal airway/lung tissues...
January 5, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28056048/copd-in-hiv-infected-patients-cd4-cell-count-highly-correlated
#11
Karine Risso, Francine Guillouet-de-Salvador, Laure Valerio, Pascal Puglièse, Alissa Naqvi, Jacques Durant, Elisa Demonchy, Isabelle Perbost, Eric Cua, Charles-Hugo Marquette, Pierre-Marie Roger
BACKGROUND: COPD is a frequent and significant cause of respiratory morbidity in HIV-infected patients despite the control of HIV. We aimed to analyze the factors correlated with COPD in this population to evaluate the existence of specific indicators of vulnerability in this population. METHODS AND FINDINGS: 623 HIV-infected outpatients were enrolled during one year. This population was characterised by a dedicated questionnaire and electronic patient records. COPD screening was performed according to recommended spirometric criteria...
2017: PloS One
https://www.readbyqxmd.com/read/28055281/effects-of-bronchoscopy-on-lung-function-in-asthmatics
#12
Christina Bellinger, Eugene R Bleecker, Stephen P Peters, Rodolfo M Pascual, Jeffrey Krings, Regina V Smith, Annette Hasties, Wendy C Moore
BACKGROUND: To better understand changes in pulmonary physiology related to asthma severity following bronchoscopy, we performed scheduled pre- and post-procedure spirometry on all subjects undergoing bronchoscopy in our research program. METHODS: Control subjects and asthma subjects of all severity were recruited for bronchoscopy. On the day of bronchoscopy, subjects underwent spirometry when they arrived, after pre-bronchoscopy treatment with albuterol and then up to three sets within two hours following completion of the bronchoscopy...
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28054389/health-effects-of-laser-printer-emissions-a-controlled-exposure-study
#13
Stefan Karrasch, Myriam Simon, Britta Herbig, Jeanette Langner, Stefan Seeger, Angelika Kronseder, Stefan Peters, Gisela Dietrich-Gümperlein, Rudolf Schierl, Dennis Nowak, Rudolf A Jörres
Ultrafine particles emitted from laser printers are suspected to elicit adverse health effects. We performed 75-minute exposures to emissions of laser printing devices (LPDs) in a standardized, randomized, cross-over manner in 23 healthy subjects, 14 mild, stable asthmatics and 15 persons reporting symptoms associated with LPD emissions. Low level exposures (LLE) ranged at the particle background (3,000 cm(-3) ), high level exposures (HLE) at 100,000 cm(-3) . Examinations before and after exposures included spirometry, body plethysmography, transfer factors for CO and NO (TLCO, TLNO), bronchial and alveolar NO, cytokines in serum and nasal secretions (IL-1β, IL-5, IL-6, IL-8, GM-CSF, IFNγ, TNFα), serum ECP, and IgE...
January 5, 2017: Indoor Air
https://www.readbyqxmd.com/read/28053971/gold-criteria-overestimate-airflow-limitation-in-one-third-of-cases-in-the-general-finnish-population
#14
Annette Kainu, Kirsi Timonen, Ari Lindqvist, Päivi Piirilä
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) diagnostic criteria for chronic obstructive pulmonary disease (COPD) use a fixed threshold of forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio (<0.70) in post-bronchodilation spirometry to indicate disease, which has been shown to underestimate and overestimate disease prevalence in younger and older adults, respectively, whilst criteria based on reference values have better accuracy. Differences in reference values have limited their use in international studies...
October 2016: ERJ Open Research
https://www.readbyqxmd.com/read/28053968/electromagnetic-inductance-plethysmography-is-well-suited-to-measure-tidal-breathing-in-infants
#15
Mariann H L Bentsen, Morten Eriksen, Merete S Olsen, Trond Markestad, Thomas Halvorsen
Reliable, accurate and noninvasive methods for measuring lung function in infants are desirable. Electromagnetic inductance plethysmography has been used to perform infant spirometry and VoluSense Pediatrics (VSP) (VoluSense, Bergen, Norway) represents an updated version of this technique. We aimed to examine its accuracy compared to a validated system measuring airflow via a facemask using an ultrasonic flowmeter. We tested 30 infants with postmenstrual ages between 36 to 43 weeks and weights from 2.3 to 4...
October 2016: ERJ Open Research
https://www.readbyqxmd.com/read/28053518/initiation-of-triple-therapy-maintenance-treatment-among-patients-with-copd-in-the-us
#16
Jason C Simeone, Rakesh Luthra, Shuchita Kaila, Xiaoyun Pan, Tarun D Bhagnani, Jieruo Liu, Teresa K Wilcox
BACKGROUND: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends triple therapy (long-acting muscarinic receptor antagonists, long-acting beta-2 agonists, and inhaled corticosteroids) for patients with only the most severe COPD. Data on the proportion of COPD patients on triple therapy and their characteristics are sparse and dated. Objective 1 of this study was to estimate the proportion of all, and all treated, COPD patients receiving triple therapy. Objective 2 was to characterize those on triple therapy and assess the concordance of triple therapy use with GOLD guidelines...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28052294/comparison-of-three-screening-questionnaires-for-chronic-obstructive-pulmonary-disease-in-the-primary-care
#17
Dionisios Spyratos, Anna-Bettina Haidich, Diamantis Chloros, Dionisia Michalopoulou, Lazaros Sichletidis
BACKGROUND: Even though the diagnosis of chronic obstructive pulmonary disease (COPD) is easy and based mainly on spirometry and symptoms, the prevalence of underdiagnosis is extremely high. The use of simple screening tools (e.g., questionnaires, hand-held spirometers) has been proved to be a simple method for case finding of COPD. Nevertheless the most appropriate target group of the general population has not been specified yet. OBJECTIVES: The aim of the present study was to compare 3 screening questionnaires among smokers aged >40 years in the primary care setting...
January 5, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28051194/respiratory-symptoms-and-lung-function-among-greek-cotton-industry-workers-a-cross-sectional-study
#18
Ioannis D Anyfantis, Georgios Rachiotis, Cristos Hadjichristodoulou, Konstantinos I Gourgoulianis
BACKGROUND: Workers in cotton industry are occupationally exposed to various dust-related hazards. The nature of these agents and the respective exposure levels depend on the cotton industry specific sector. These exposures could be associated with respiratory symptoms and changes in lung function parameters. OBJECTIVE: To evaluate associations between occupational exposure and respiratory function as well as reported symptoms in several groups of workers at different stages of the cotton industry in a vertical approach that covers all the major sectors-from cotton ginning to weaving and fabric production...
January 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28047708/th-cd-207a-05-lung-surface-deformation-vector-fields-prediction-by-monitoring-respiratory-surrogate-signals
#19
J Nasehi Tehrani, A McEwan, J Wang
PURPOSE: In this study, we developed and evaluated a method for predicting lung surface deformation vector fields (SDVFs) based on surrogate signals such as chest and abdomen motion at selected locations and spirometry measurements. METHODS: A Patient-specific 3D triangular surface mesh of the lung region at end-expiration (EE) phase was obtained by threshold-based segmentation method. For each patient, a spirometer recorded the flow volume changes of the lungs; and 192 selected points at a regular spacing of 2cm X 2cm matrix points over a total area of 34cm X 24cm on the surface of chest and abdomen was used to detect chest wall motions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047108/su-d-202-07-clinical-applicability-of-an-optical-surface-imaging-based-technique-for-spirometric-measurement-breathing-pattern-monitoring-and-body-drift-correction
#20
S Zhang, H Huang, J Wei, G Li
PURPOSE: To explore the capabilities of optical surface imaging (OSI) as a comprehensive tumor motion surrogate to provide dynamic spirometric measurements, breathing pattern monitoring and body positioning correction. METHODS: OSI captures the moving surface of the torso with all respiration-induced external motions in real time. Tidal volume (TV) and its time derivative (TV', airflow) were measured based on the volume conservation rule within the pseudo-closed torso system: torso volume change equals TV in reference to full exhalation...
June 2016: Medical Physics
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