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Endobronchial

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https://www.readbyqxmd.com/read/29150904/endobronchial-drug-delivery-expanding-techniques-and-possibilities-in-interventional-pulmonology
#1
EDITORIAL
Daniel P Steinfort
No abstract text is available yet for this article.
November 17, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29139187/pharmacokinetics-and-safety-of-paclitaxel-delivery-into-porcine-airway-walls-by-a-new-endobronchial-drug-delivery-catheter
#2
Hisashi Tsukada, Plamena Entcheva-Dimitrov, Armin Ernst, Samaan Rafeq, John H Keating, Kirk P Seward, Lonny Yarmus
BACKGROUND AND OBJECTIVE: Intratumoral administration of chemotherapeutic agents is a treatment modality that has proven efficacious in reducing the recurrence of tumours and increases specificity of treatment while minimizing systemic side effects. Direct intratumoral injection of malignant airway obstruction has potential therapeutic benefits but tissue drug concentrations and side-effect profiles are poorly understood. METHODS: Bronchial wall injection of generic paclitaxel (PTX) (102 injections of 0...
November 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29139101/-endobronchial-ultrasound-ebus-an-update-2017
#3
K Darwiche, F Özkan, C Wolters, S Eisenmann
Endobronchial Ultrasound (EBUS) with the two modalities curved and radial EBUS significantly improved the diagnostics in several pulmonary diseases. The examination and staging of mediastinal and hilar lymph nodes in patients with known or suspected lung malignancy as well as the evaluation of unknown pulmonary or mediastinal lesions can be achieved with minimal invasive means when using EBUS. More invasive surgical procedures for diagnostic purposes can be omitted. The diagnostic yield also increases when EBUS is applied in sarcoidosis or mediastinal lymph node tuberculosis but only to some extend in case of lymphoma...
November 2017: Pneumologie
https://www.readbyqxmd.com/read/29138655/endobronchial-localization-of-hodgkin-s-disease
#4
Lamyae Amro, Siham Jridi, Hafsa Sajiai, Hind Serhane, Salma Aït Batahar
The endobronchial localization of Hodgkin's disease is a rare entity which is often confused with endobronchial tuberculosis in our setting. We report the case of a 16 years old female who presented with 6 months history of dry cough, hemoptysis, dyspnea, dysphagia and dysphonia. The chest radiography showed a mediastinal and pulmonary opacity. The chest CT scan found enlarged mediastinal lymph nodes. The bronchial biopsy and peripheral lymph node biopsy confirmed Hodgkin's disease with endobronchial localization...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29136621/evaluation-of-nickel-release-from-endobronchial-valves-as-a-possible-cause-of-hypersensitivity-pneumonitis-in-a-patient-treated-with-bronchoscopic-lung-volume-reduction
#5
Daniel P Franzen, Claudia Lang, Nikos Agorastos, Lutz Freitag, Malcolm Kohler, Peter Schmid-Grendelmeier
BACKGROUND: Endobronchial valve (EBV) placement is an established lung volume reduction procedure aiming to improve lung function and exercise capacity in patients with severe emphysema. As EBVs consist of silicone and nitinol (a metal alloy of nickel and titanium), there are concerns that nickel ions might be released and could have a clinical impact in patients with a contact allergy to nickel. Based on a case with hypersensitivity pneumonitis (HP) after treatment with EBVs, we aimed to evaluate the in vitro nickel release from EBVs using inductively coupled plasma mass spectrometry (ICP-MS) and scanning electron microscopy (SEM)...
November 15, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29132804/a-randomized-controlled-trial-comparing-the-utility-of-lighted-stylet-and-glidescope-for-double-lumen-endobronchial-intubation
#6
Jee-Eun Chang, Hyerim Kim, Seong-Won Min, Jung-Man Lee, Jung-Hee Ryu, Soohyuk Yoon, Jin-Young Hwang
OBJECTIVE: To compare GlideScope and lighted stylet for double-lumen endobronchial tube (DLT) intubation in terms of intubation time, success rate of first attempt at intubation, difficulty in DLT advancement toward the glottis, and postoperative sore throat and hoarseness. DESIGN: A prospective, randomized study. SETTING: Medical center governed by a university hostpial. PARTICIPANTS: Sixty-two adult patients undergoing thoracic surgery using DLT intubation...
October 7, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29132465/-application-of-flexible-bronchoscopy-in-children-with-respiratory-diseases
#7
Li-Ping Wang, Shou-Ping Chen, Yu-Ying Huang, Fang-Fang Qin, Wen Ou, Hong-Dong Liu, Xiao-Fang Deng, Lei Lou, Jing Tao, Yu-Xia Cui
OBJECTIVE: To investigate the significance of flexible bronchoscopy in children with respiratory diseases. METHODS: A retrospective analysis was performed for the clinical data of 80 children who were hospitalized due to respiratory diseases (including severe pneumonia, Mycoplasma pneumoniae pneumonia with atelectasis/lung consolidation/local emphysema, protracted pneumonia, coughing and wheezing of unknown cause, chronic cough of unknown cause, and laryngeal stridor) and who underwent flexible bronchoscopy/alveolar lavage...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29131539/molecular-testing-on-endobronchial-ultrasound-ebus-fine-needle-aspirates-fna-impact-of-triage
#8
Simon Sung, John P Crapanzano, David DiBardino, David Swinarski, William A Bulman, Anjali Saqi
BACKGROUND: Endobronchial ultrasound (EBUS)-guided fine needle aspiration (FNA) is performed to diagnose and stage lung cancer. Multiple studies have described the value of Rapid On-Site Evaluation (ROSE), but often the emphasis is upon diagnosis than adequacy for molecular testing (MT). The aim was to identify variable(s), especially cytology-related, that can improve MT. METHODS: A search for EBUS-FNAs with ROSE was conducted for lung adenocarcinomas or when this diagnosis could not be excluded...
November 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29129114/image-guided-surgery-and-therapy-for-lung-cancer-a-critical-review
#9
Keyvan Moghissi, Kate Dixon
Of the many imaging technologies, some have the potential to be used in image-guided surgery and therapy (IGS/IGT). This review of relevant papers on IGS/IGT for lung cancer indicates effective localization and IGS/IGT in early endobronchial lesions by fluorescence bronchoscopic technique. Visualization of early peripheral (nodular) tumors at operation can be achieved by a variety of imaging methods and devices which allow identification, localization and provision of intraoperative real-time images. Recent developments employing fluorescence contrasts and near infra-red light have shown encouraging feasibility and outcome in providing reliable methods for the IGS of cancer generally and lung cancer more specifically with provision of real time intraoperative imaging...
November 13, 2017: Future Oncology
https://www.readbyqxmd.com/read/29124891/the-diagnostic-value-of-tissue-button-technique-for-specimen-accusation-during-endobronchial-ultrasound-guided-transbronchial-fine-needle-aspiration
#10
Oren Fruchter, Anna Breslavsky, Tatyana Brozgol, Anna Grossman, Kessi Mikhailova, Alexey Bugayov, Kassa Shimelis, Hananya Vaknine, Oleg Sukmanov
INTRODUCTION: The quality of tissue acquisition during Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a major determinant of the diagnostic yield of the procedure. In the tissue button (TB ) technique the retrieved cellular specimen is fixed in ethanol and subsequently scraped from slide using surgical blade into formaldehyde and processed like ordinary tissue biopsy thus potentially increasing its diagnostic value. OBJECTIVES: To retrospectively evaluate the diagnostic yield of a TB technique in patients undergoing EBUS-TBNA for various malignant and benign conditions...
November 10, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29122457/radiotherapy-for-tracheal-bronchial-cystic-adenoid-carcinomas
#11
A Levy, A Omeiri, E Fadel, C Le Péchoux
AIMS: Primary tracheal-bronchial adenoid cystic carcinoma (thoracic adenoid cystic carcinoma; TACC) is a rare and aggressive malignant tumour. Radiotherapy results have not been previously individualised in this setting. PATIENTS AND METHODS: Records of 31 patients with TACC (74% tracheal and 26% bronchial) who received radiotherapy between February 1984 and September 2014 were retrospectively analysed. RESULTS: Surgical removal of the primary tumour was carried out for most (71%) patients, and 13/22 (59%) had R1 or R2 (1/22) margins...
November 6, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29120502/necrotizing-microascus-tracheo-bronchitis-in-a-bilateral-lung-transplant-recipient
#12
Olivier Taton, Benjamin Bernier, Isabelle Etienne, Benjamin Bondue, Sophie Lecomte, Christiane Knoop, Frederique Jacob, Isabel Montesinos
Invasive fungal infections are a major cause of mortality among solid organ transplant recipients. Scopulariopsis species and their teleomorph Microascus are molds found in soil and decaying organic matter. We report here the case of a woman who underwent bilateral lung transplantation for severe emphysema. On day 25 after transplantation, endobronchial green-black lesions were detected during routine endoscopy. Endobronchial swabs, biopsies, and broncho-alveolar lavage samples were positive for Microascus cirrosus...
November 9, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29119620/identification-of-oestrogen-progesterone-receptor-and-human-epidermal-growth-factor-receptor-2-expression-in-mediastinal-metastases-of-breast-cancer-obtained-by-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#13
P Serra, J Sanz-Santos, E Castellà, B Cirauqui, F Andreo, M Llatjós, M Avila, M Margelí, L Serrano, C Centeno, V Quiroga, M Torky, J Ruiz-Manzano
BACKGROUND: In breast cancer patients, the expression statuses of oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are crucial in the choice of treatment. Receptor expression in metastatic lesions can differ from the primary tumour. The aim of our study was to analyse the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to obtain samples allowing the identification of ER, PR and HER2 expression in patients with mediastinal metastases of breast cancer...
November 9, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29117314/assessment-of-fluorodeoxyglucose-f18-labeled-positron-emission-tomography-for-diagnosis-of-high-risk-lung-nodules
#14
Amelia W Maiga, Stephen A Deppen, Sarah Fletcher Mercaldo, Jeffrey D Blume, Chandler Montgomery, Laszlo T Vaszar, Christina Williamson, James M Isbell, Otis B Rickman, Rhonda Pinkerman, Eric S Lambright, Jonathan C Nesbitt, Eric L Grogan
Importance: Clinicians rely heavily on fluorodeoxyglucose F18-labeled positron emission tomography (FDG-PET) imaging to evaluate lung nodules suspicious for cancer. We evaluated the performance of FDG-PET for the diagnosis of malignancy in differing populations with varying cancer prevalence. Objective: To determine the performance of FDG-PET/computed tomography (CT) in diagnosing lung malignancy across different populations with varying cancer prevalence. Design, Setting, and Participants: Multicenter retrospective cohort study at 6 academic medical centers and 1 Veterans Affairs facility that comprised a total of 1188 patients with known or suspected lung cancer from 7 different cohorts from 2005 to 2015...
November 8, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29114418/stop-being-so-sensitive-an-exceptionally-rare-report-of-ustekinumab-induced-sub-acute-hypersensitivity-pneumonitis
#15
Azka Ali, Jason Chertoff, Christopher Harden, Dara Wakefield, James Wynne
Hypersensitivity pneumonitis (HSP) is a rare syndrome characterised by granulomatous inflammatory lung disease due to repeated sensitisation from a specific antigen. We present the case of a 61-year old male veteran with a history of nodular eczema who presented with 2 weeks of progressive dyspnoea on exertion and pleuritic chest pain. The patient was started on ustekinumab 5 weeks prior to presentation. Initial workup revealed ground-glass opacities on computed tomography (CT) scan of the chest. Cardiac workup was unrevealing with a normal myocardial perfusion stress test...
October 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/29110850/nanoparticle-targeted-folate-receptor-1-enhanced-photodynamic-therapy-for-lung-cancer
#16
Tatsuya Kato, Cheng S Jin, Hideki Ujiie, Daiyoon Lee, Kosuke Fujino, Hironobu Wada, Hsin-Pei Hu, Robert A Weersink, Juan Chen, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Brian C Wilson, Gang Zheng, Kazuhiro Yasufuku
OBJECTIVE: Despite modest improvements, the prognosis of lung cancer patients has still remained poor and new treatment are urgently needed. Photodynamic therapy (PDT), the use of light-activated compounds (photosensitizers) is a treatment option but its use has been restricted to central airway lesions. Here, we report the use of novel porphyrin-lipid nanoparticles (porphysomes) targeted to folate receptor 1 (FOLR1) to enhance the efficacy and specificity of PDT that may translate into a minimally-invasive intervention for peripheral lung cancer and metastatic lymph nodes of advanced lung cancer...
November 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29110704/endobronchial-one-way-valves-for-treatment-of-persistent-air-leaks-a-systematic-review
#17
REVIEW
Mei Ding, Ya-Dong Gao, Xian-Tao Zeng, Yi Guo, Jiong Yang
Persistent air leak (PAL) is associated with significant morbidity and mortality, prolonged hospitalization and increased health-care costs. It can arise from a number of conditions, including pneumothorax, necrotizing infection, trauma, malignancies, procedural interventions and complications after thoracic surgery. Numerous therapeutic options, including noninvasive and invasive techniques, are available to treat PALs. Recently, endobronchial one-way valves have been used to treat PAL. We conducted a systematic review based on studies retrieved from PubMed, EMbase and Cochrane library...
November 6, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29109057/broncho-pleural-fistula-after-pneumonectomy-risk-factors-and-management-focusing-on-open-window-thoracostomy
#18
Antonio Mazzella, Alessandro Pardolesi, Patrick Maisonneuve, Francesco Petrella, Domenico Galetta, Roberto Gasparri, Lorenzo Spaggiari
OBJECTIVE: We evaluated principal risk factors and different therapeutic approaches for post-pneumonectomy broncho-pleural fistula (BPF), focusing on open window thoracostomy (OWT). METHODS: We have retrospectively reviewed all patients treated by pneumonectomy for lung cancer from 1999 to 2014; we evaluated preoperative, operative and postoperative data, time between operation and fistula formation, size, treatment and predicting factors of BPF. Cumulative incidence curves for the development of BPF were drawn according to the Kaplan-Meier Method...
November 3, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29106573/endobronchial-brachytherapy-with-curative-intent-the-impact-of-reference-points-setting-according-to-the-bronchial-diameter
#19
Yoshihito Nomoto, Noriko Ii, Shuichi Murashima, Yasufumi Yamashita, Satoru Ochiai, Akinori Takada, Yutaka Toyomasu, Tomoko Kawamura, Hajime Sakuma
Endobronchial brachytherapy (EBB) is an effective treatment for endobronchial tumors. However, bronchial toxicity caused by over-irradiation remains problematic. To decrease bronchial toxicity, we developed a source-centralizing applicator for EBB. The purpose of the present study was to assess the efficacy and safety of EBB with varying reference dose points according to the bronchial diameter, using a source-centralizing applicator. We reviewed 15 patients with endobronchial carcinoma who were treated with curative intent using a combination of external beam radiotherapy (EBRT) and high-dose-rate EBB between 2005 and 2014...
July 1, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29105909/endobronchial-valve-placement-in-emphysema-when-is-it-lung-volume-reduction
#20
EDITORIAL
Ralf Eberhardt
No abstract text is available yet for this article.
November 5, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
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