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Cartilage biology

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https://www.readbyqxmd.com/read/28213717/the-minor-collagens-in-articular-cartilage
#1
REVIEW
Yunyun Luo, Dovile Sinkeviciute, Yi He, Morten Karsdal, Yves Henrotin, Ali Mobasheri, Patrik Önnerfjord, Anne Bay-Jensen
Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions...
February 17, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28210648/utilization-of-platelet-rich-plasma-for-musculoskeletal-injuries-an-analysis-of-current-treatment-trends-in-the-united-states
#2
Joanne Y Zhang, Peter D Fabricant, Chad R Ishmael, Jeffrey C Wang, Frank A Petrigliano, Kristofer J Jones
BACKGROUND: Platelet-rich plasma (PRP) has emerged as a popular biologic treatment for musculoskeletal injuries and conditions. Despite numerous investigations on the efficacy of PRP therapy, current utilization of this treatment within the United States is not widely known. PURPOSE: To investigate the national utilization of PRP, including the incidence and conditions for which it is used in the clinical setting, and to determine the current charges associated with this treatment...
December 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28203112/bone-contusion-progression-from-traumatic-knee-injury-association-of-rate-of-contusion-resolution-with-injury-severity
#3
Douglas R Pedersen, Georges Y El-Khoury, Dan R Thedens, Mothana Saad-Eldine, Phinit Phisitkul, Annunziato Amendola
BACKGROUND: Bone contusions are frequently encountered in magnetic resonance imaging (MRI) evaluation of knee anterior cruciate ligament (ACL) injuries. Their role as indicators of injury severity remains unclear, primarily due to indeterminate levels of joint injury forces and to a lack of preinjury imaging. PURPOSE: The purpose of this study was to 1) quantify bone contusion pathogenesis following traumatic joint injuries using fixed imaging follow-ups, and 2) assess the feasibility of using longitudinal bone contusion volumes as an indicator of knee injury severity...
2017: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/28202920/cartilage-targeting-drug-delivery-can-electrostatic-interactions-help
#4
REVIEW
Ambika G Bajpayee, Alan J Grodzinsky
Current intra-articular drug delivery methods do not guarantee sufficient drug penetration into cartilage tissue to reach cell and matrix targets at the concentrations necessary to elicit the desired biological response. Here, we provide our perspective on the utilization of charge-charge (electrostatic) interactions to enhance drug penetration and transport into cartilage, and to enable sustained binding of drugs within the tissue's highly negatively charged extracellular matrix. By coupling drugs to positively charged nanocarriers that have optimal size and charge, cartilage can be converted from a drug barrier into a drug reservoir for sustained intra-tissue delivery...
February 9, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28194388/in-vivo-evaluation-of-porous-hydrogel-pins-to-fill-osteochondral-defects-in-rabbits
#5
Túlio Pereira Cardoso, André Petry Sandoval Ursolino, Pamela de Melo Casagrande, Edie Benedito Caetano, Daniel Vinicius Mistura, Eliana Aparecida de Rezende Duek
OBJECTIVE: This experimental study aimed to evaluate the biological performance of poly (l-co-D, l-lactic acid)-co-trimetilene carbonate/poly (vinyl alcohol) (PLDLA-co TMC/PVA), hydrogel scaffolds, as an implant in the filling (and not in the repair) of osteochondral defects in New Zealand rabbits, assessing the influence of the material in tissue protection in vivo. METHODS: Twelve rabbits were divided into groups of nine and 16 weeks. In each animal, an osteochondral defect was created in both medial femoral condyles...
January 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28193015/derivatization-strategies-for-the-detection-of-triamcinolone-acetonide-in-cartilage-by-using-matrix-assisted-laser-desorption-ionization-mass-spectrometry-imaging
#6
Florian P Y Barré, Bryn Flinders, João P Garcia, Imke Jansen, Lennart R S Huizing, Tiffany Porta, Laura B Creemers, Ron M A Heeren, Berta Cillero-Pastor
Osteoarthritis (OA), characterized by degeneration of the cartilaginous tissue in articular joints, severely impairs mobility in many people worldwide. The degeneration is thought to be mediated by inflammatory processes occurring in the tissue of the joint, including the cartilage. Intra-articular administered triamcinolone acetonide (TAA) is one of the drug treatments employed to ameliorate the inflammation and pain that characterizes OA. However, the penetration and distribution of TAA into the avascular cartilage is not well understood...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28192200/the-binding-capacity-of-%C3%AE-1%C3%AE-1-%C3%AE-2%C3%AE-1-and-%C3%AE-10%C3%AE-1-integrins-depends-on-non-collagenous-surface-macromolecules-rather-than-the-collagens-in-cartilage-fibrils
#7
Christian Woltersdorf, Melanie Bonk, Birgit Leitinger, Mikko Huhtala, Jarmo Käpylä, Jyrki Heino, Christian Gil Girol, Stephan Niland, Johannes A Eble, Peter Bruckner, Rita Dreier, Uwe Hansen
Interactions of cells with supramolecular aggregates of the extracellular matrix (ECM) are mediated, in part, by cell surface receptors of the integrin family. These are important molecular components of cell surface-suprastructures regulating cellular activities in general. A subfamily of β1-integrins with von Willebrand-factor A-like domains (I-domains) in their α-chains can bind to collagen molecules and, therefore, are considered as important cellular mechano-receptors. Here we show that chondrocytes strongly bind to cartilage collagens in the form of individual triple helical molecules but very weakly to fibrils formed by the same molecules...
February 10, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/28181432/mimicking-hierarchical-complexity-of-the-osteochondral-interface-using-electrospun-silk-bioactive-glass-composites
#8
Joseph Christakiran M, Philip James Thomas Reardon, Rocktotpal Konwarh, Jonathan C Knowles, Biman B Mandal
The anatomical complexity and slow regeneration capacity of hyaline cartilage at the osteochondral interface pose a great challenge in the repair of osteochondral defects (OCD). In this study, we utilized the processing feasibility offered by the sol derived 70S bioactive glass and silk fibroin (mulberry Bombyx mori and endemic Indian non-mulberry Antheraea assama), in fabricating a well-integrated, biomimetic scaffolding matrix with a coherent interface. Differences in surface properties such as wettability and amorphousness between the two silk groups resulted in profound variations in cell attachment and extracellular matrix protein deposition...
February 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28169595/tissue-derived-extracellular-matrix-bioscaffolds-emerging-applications-in-cartilage-and-meniscus-repair
#9
Farrah A Monibi, James Lee Cook
Musculoskeletal injuries are a common and significant problem in orthopaedic practice. Given the long-term consequences of unaddressed cartilage and meniscal pathology, a number of treatments have been attempted to stimulate repair or to replace the injured tissue. Despite advances in orthopaedic surgery, effective treatments for cartilage and meniscus injuries remain a common and significant clinical challenge. Tissue engineering is a developing field that aims to regenerate injured tissues with a combination of cells, scaffolds, and signals...
February 7, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28169453/mechanical-properties-and-structure-function-relationships-of-human-chondrocyte-seeded-cartilage-constructs-after-in-vitro-culture
#10
Jill M Middendorf, Darvin J Griffin, Sonya Shortkroff, Caroline Dugopolski, Stephen Kennedy, Joseph Siemiatkoski, Itai Cohen, Lawrence J Bonassar
Autologous Chondrocyte Implantation (ACI) is a widely recognized method for the repair of focal cartilage defects. Despite the accepted use, problems with this technique still exist, including graft hypertrophy, damage to surrounding tissue by sutures, uneven cell distribution, and delamination. Modified ACI techniques overcome these challenges by seeding autologous chondrocytes onto a 3D scaffold and securing the graft into the defect. Many studies on these tissue engineered grafts have identified the compressive properties, but few have examined frictional and shear properties as suggested by FDA guidance...
February 7, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28155831/chondroitin-application-in-the-treatment-of-degenerative-joint-disease
#11
Wiesław Tomaszewski
Chondroitin is an organic compound, belonging to the group of glycosaminoglycans. In the treatment of degenerative joint disease, aka osteoarthritis, chondroitin sulphate is applied as a medicine or a dietary supplement. The biological importance of chondroitin sulphate has been already largely determined. The newest data on glycobiology research suggest that proteoglycans, as well as their complex polysaccharide macroparticles not only are the structural elements, but also they participate in multiple metabolic processes at a molecular level as well as in the physiological processes, regulating this type of mechanisms...
November 30, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28155218/expression-profiles-of-angiogenesis-in-two-high-grade-chondrosarcomas-a-xenotransplant-experience-in-nude-mice
#12
Francisco Giner, José Antonio López-Guerrero, Isidro Machado, Zaida García-Casado, Antonio Fernández-Serra, Amando Peydró-Olaya, Antonio Llombart-Bosch
BACKGROUND: Chondrosarcomas (Chs) are malignant cartilage-forming tumors that represent the third most common malignant solid tumor of bone in adults. Angiogenesis is a major factor for tumor growth and metastasis. Our aim was to make a histological, immunohistochemical, ultrastructural and molecular characterization of the neovascularization established between xenotransplanted Chs and the host during the initial phases of growth in nude transfer, in order to find potential markers for distinguishing between high grades II and III Chs...
February 3, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28144574/current-management-of-talar-osteochondral-lesions
#13
REVIEW
Arianna L Gianakos, Youichi Yasui, Charles P Hannon, John G Kennedy
Osteochondral lesions of the talus (OLT) occur in up to 70% of acute ankle sprains and fractures. OLT have become increasingly recognized with the advancements in cartilage-sensitive diagnostic imaging modalities. Although OLT may be treated nonoperatively, a number of surgical techniques have been described for patients whom surgery is indicated. Traditionally, treatment of symptomatic OLT have included either reparative procedures, such as bone marrow stimulation (BMS), or replacement procedures, such as autologous osteochondral transplantation (AOT)...
January 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28138955/recent-advances-in-hydrogels-for-cartilage-tissue-engineering
#14
S L Vega, M Y Kwon, J A Burdick
Articular cartilage is a load-bearing tissue that lines the surface of bones in diarthrodial joints. Unfortunately, this avascular tissue has a limited capacity for intrinsic repair. Treatment options for articular cartilage defects include microfracture and arthroplasty; however, these strategies fail to generate tissue that adequately restores damaged cartilage. Limitations of current treatments for cartilage defects have prompted the field of cartilage tissue engineering, which seeks to integrate engineering and biological principles to promote the growth of new cartilage to replace damaged tissue...
January 30, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28131109/fabrication-of-chitosan-silk-based-tracheal-scaffold-using-freeze-casting-method
#15
Zeinab Nematollahi, Mohammad Tafazzoli-Shadpour, Ali Zamanian, Amir Seyedsalehi, Shadmehr Mohammad-Behgam, Fariba Ghorbani, Fereshte Mirahmadi
Background: Since the treatments of long tracheal leisions are associated with some limitations, tissue enginered trachea is considered as an alternative option. This study aimed at preparing a composite scaffold, based on natural and synthetic materials for tracheal tissue engineering. Methods: Nine chitosan silk-based scaffolds were fabricated using three freezing rates (0.5, 1, and 2°C/min) and glutaraldehyde (GA) concentrations (0, 0.4, and 0.8 wt%). Samples were characterized, and scaffolds having mechanical properties compatible with those of human trachea and proper biodegradability were selected for chondrocyte cell seeding and subsequent biological assessments...
29, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28126377/defects-in-lymphocyte-telomere-homeostasis-contribute-to-cellular-immune-phenotype-in-cartilage-hair-hypoplasia
#16
Geraldine Aubert, Kevin A Strauss, Peter M Lansdorp, Nicholas L Rider
BACKGROUND: Mutations in the lncRNA RNase component of the Mitochondrial RNA Processing endoribonuclease (RMRP) give rise to the autosomal recessive condition cartilage-hair hypoplasia (CHH). The CHH disease phenotype has some overlap with dyskeratosis congenita, a well known "telomere disorder". RMRP binds the telomerase reverse transcriptase protein TERT in some cell lines, raising the possibility that RMRP may play a role in telomere biology. OBJECTIVE: We sought to determine if a telomere phenotype is present in immune cells from individuals with CHH and explore mechanisms underlying these observations...
January 23, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28123295/platelet-functionalized-three-dimensional-poly-%C3%AE%C2%B5-caprolactone-fibrous-scaffold-prepared-using-centrifugal-spinning-for-delivery-of-growth-factors
#17
Michala Rampichová, Matej Buzgo, Andrea Míčková, Karolína Vocetková, Věra Sovková, Věra Lukášová, Eva Filová, Franco Rustichelli, Evžen Amler
Bone and cartilage are tissues of a three-dimensional (3D) nature. Therefore, scaffolds for their regeneration should support cell infiltration and growth in all 3 dimensions. To fulfill such a requirement, the materials should possess large, open pores. Centrifugal spinning is a simple method for producing 3D fibrous scaffolds with large and interconnected pores. However, the process of bone regeneration is rather complex and requires additional stimulation by active molecules. In the current study, we introduced a simple composite scaffold based on platelet adhesion to poly-ε-caprolactone 3D fibers...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28121190/the-biology-of-meniscal-pathology-in-osteoarthritis-and-its-contribution-to-joint-disease-beyond-simple-mechanics
#18
James Melrose, Emily S Fuller, Christopher B Little
The meniscal cartilages in the knee function to improve congruity of the medial and lateral femoro-tibial joints, and play critical roles in load distribution and joint stability. Meniscal tears of various configurations are one of the most common conditions of the knee, and are associated with an increased risk of developing osteoarthritis (OA). While this risk has been largely attributed to loss of the biomechanical functions of the menisci, there is accumulating evidence suggesting that other aspects of meniscal biology may play a role in determining the long-term consequences of meniscal damage for joint health...
January 25, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28116632/itraq-based-quantitative-proteomic-analysis-on-differentially-expressed-proteins-of-rat-mandibular-condylar-cartilage-induced-by-reducing-dietary-loading
#19
Liting Jiang, Yinyin Xie, Li Wei, Qi Zhou, Ning Li, Xinquan Jiang, Yiming Gao
As muscle activity during growth is considerably important for mandible quality and morphology, reducing dietary loading directly influences the development and metabolic activity of mandibular condylar cartilage (MCC). However, an overall investigation of changes in the protein composition of MCC has not been fully described in literature. To study the protein expression and putative signaling in vivo, we evaluated the structural changes of MCC and differentially expressed proteins induced by reducing functional loading in rat MCC at developmental stages...
January 23, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28109571/in%C3%A2-vivo-tissue-engineering-of-human%C3%A2-airways
#20
Emmanuel Martinod, Joseph Paquet, Hervé Dutau, Dana M Radu, Morad Bensidhoum, Sébastien Abad, Yurdagül Uzunhan, Eric Vicaut, Hervé Petite
BACKGROUND: Airway transplantation remains a major challenge in thoracic surgery. Based on our previous laboratory work, we developed the techniques required to bioengineer a tracheal substitute in vivo using cryopreserved aortic allografts as biological matrices (Replacement of the Airways and/or the Pulmonary Vessels Using a Cryopreserved Arterial Allograft [TRACHEOBRONCART] Study, NCT01331863). We present here 2 patients who had a definitive tracheostomy for complex laryngotracheal stenoses refractory to conventional therapy...
January 18, 2017: Annals of Thoracic Surgery
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