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https://www.readbyqxmd.com/read/28742964/conformational-flexibility-and-self-association-of-fibrinogen-in-concentrated-solutions
#1
Yuriy F Zuev, Rustem I Litvinov, Alexander E Sitnitsky, Bulat Z Idiyatullin, Dilyafruz R Bakirova, Dennis Galanakis, Artem Zhmurov, Valeri Barsegov, John W Weisel
We studied the hydrodynamic behavior of fibrinogen, a blood plasma protein involved in blood clotting, in a broad 0.3-60 mg/ml range of concentration and 5-42°C temperature using pulsed-field gradient 1H NMR-diffusometry. Arrhenius plots revealed the activation energy for fibrinogen diffusion Ed = 21.3 kJ/mol at 1.4 mg/ml and 28.4 kJ/mol at 38 mg/ml. We found a dramatic slowdown in fibrinogen self-diffusion with concentration beginning at 1.7-3.4 mg/ml, which deviated from the standard hard-particle behavior, suggesting a remarkable intermolecular entanglement...
July 25, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28742828/feasibility-of-rigid-3d-image-registration-of-high-resolution-peripheral-quantitative-computed-tomography-images-of-healing-distal-radius-fractures
#2
Joost J A de Jong, Patrik Christen, Ryan M Plett, Roland Chapurlat, Piet P Geusens, Joop P W van den Bergh, Ralph Müller, Bert van Rietbergen
For accurate analysis of bone formation and resorption during fracture healing, correct registration of follow-up onto baseline image is required. A per-fragment approach could improve alignment compared to standard registration based on the whole fractured region. In this exploratory study, we tested the effect of fragment size and displacement on a per-fragment registration, and compared the results of this per-fragment registration to the results of the standard registration in two stable fractures and one unstable fracture...
2017: PloS One
https://www.readbyqxmd.com/read/28742827/the-relationship-between-coronary-artery-distensibility-and-fractional-flow-reserve
#3
Andy S C Yong, Ashkan Javadzadegan, William F Fearon, Abouzar Moshfegh, Jerrett K Lau, Stephen Nicholls, Martin K C Ng, Leonard Kritharides
Discordance between angiography-based anatomical assessment of coronary stenosis severity and fractional flow reserve (FFR) has been attributed to several factors including lesion length and irregularity, and the myocardial territory supplied by the target vessel. We sought to examine if coronary arterial distensibility is an independent contributor to this discordance. There were two parts to this study. The first consisted of "in silico" models of 26 human coronary arteries. Computational fluid dynamics-derived FFR was calculated for fully rigid, partially distensible and fully distensible models of the 26 arteries...
2017: PloS One
https://www.readbyqxmd.com/read/28742537/update-in-natural-orifice-translumenal-endoscopic-surgery-notes
#4
Joern Bernhardt, Sarah Sasse, Kaja Ludwig, Peter N Meier
PURPOSE OF REVIEW: The recent developments and clinical applications of natural orifice translumenal endoscopic surgery (NOTES)-procedures and technologies are going to be presented. RECENT FINDINGS: In experimental as well as clinical settings, NOTES-procedures are predominantly performed in hybrid technique. Current experimental studies focus on the implementation of new surgical approaches as well as on the training of procedures. One emphasis in the clinical application is transrectal and transanal interventions...
July 22, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28742337/gallium-complexation-stability-and-bioconjugation-of-1-4-7-triazacyclononane-derived-chelators-with-azaheterocyclic-arms
#5
Alexander Schmidtke, Tilman Läppchen, Christian Weinmann, Lorenz Bier-Schorr, Manfred Keller, Yvonne Kiefer, Jason P Holland, Mark D Bartholomä
We have recently introduced a 1,4,7-triazacyclononane (TACN) based chelating system with additional five-membered azaheterocyclic substituents for complexation of radioactive Cu(2+) ions. In this work, we investigated the complexation properties of these novel chelators with Ga(3+). In labeling experiments, we could show that the penta- and hexadentate imidazole derivatives NODIA-Me 4 and NOTI-Me 1 can be labeled with (68)Ga in specific activities up to ∼30 MBq nmol(-1), while the corresponding thiazole derivative NOTThia 2 did not label satisfactorily under identical conditions...
July 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28741627/chronic-exposure-to-methamphetamine-disrupts-reinforcement-based-decision-making-in-rats
#6
Stephanie M Groman, Katherine M Rich, Nathaniel J Smith, Daeyeol Lee, Jane R Taylor
The persistent use of psychostimulant drugs, despite the detrimental outcomes associated with continued drug use, may be due to disruptions in reinforcement-learning processes that enable behavior to remain flexible and goal-directed in dynamic environments. To identify the reinforcement-learning processes that are affected by chronic exposure to the psychostimulant methamphetamine (MA), the current study sought to use computational and biochemical analyses to characterize decision-making processes, assessed by probabilistic reversal learning, in rats before and after they were exposed to an escalating dose regimen of MA (or saline control)...
July 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28741218/asymmetric-pedicle-subtractionosteotomy-apso-guided-by-a-3d-printed-model-to-correct-a-combined-fixed-sagittal-and-coronal-imbalance
#7
Pierre-Pascal Girod, S Hartmann, P Kavakebi, J Obernauer, M Verius, C Thomé
Surgical correction of fixed thoracolumbar deformity is usually achieved by estimating the preoperatively planned correction angles during surgery and is therefore prone to inaccuracy. This is particularly problematic in biplanar deformities. To overcome these difficulties, 3D model for planning, preparation, and simulation of an asymmetric pedicle subtraction osteotomy (aPSO) was printed and used to realign coronal and sagittal balance in case of rigid degenerative kyphoscoliosis. A 59-year-old woman presented with severe back pain and spinal claudication and was diagnosed with a rigid kyphoscoliosis with multilevel spinal stenosis...
July 24, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28741111/label-free-fluorescence-turn-on-aptasensor-for-prostate-specific-antigen-sensing-based-on-aggregation-induced-emission-silica-nanospheres
#8
Rong-Mei Kong, Xiaobin Zhang, Lu Ding, Daoshan Yang, Fengli Qu
Fluorescent light-up probes based on aggregation-induced emission (AIE)-active molecules have recently attracted great research interest due to the intelligent fluorescence activation mechanism and high sensitivity. In this work, an AIE-silica nanosphere (SiO2 NP)-based label-free fluorescent aptasensor for the sensitive "turn-on" detection of prostate-specific antigen (PSA) is reported for the first time. The positively charged amino-functionalized SiO2 NPs were used as efficient nanocapturer to electrostatically adsorb single-stranded PSA aptamer (PA) to form SiO2 NP-PA nanocomposite as well as adsorb negatively charged tetraphenylethylene derivative 3 (TPE3) to form AIE-SiO2 NP nanocomposite...
July 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28740907/functional-imaging-equivalence-and-proof-of-concept-for-image-guided-adaptive-radiotherapy-with-fixed-gantry-and-rotating-couch
#9
Ilana Feain, Chun-Chien Shieh, Paul White, Ricky O'Brien, Sandra Fisher, William Counter, Peter Lazarakis, David Stewart, Simon Downes, Michael Jackson, Siddhartha Baxi, Brendan Whelan, Kuldeep Makhija, Chen-Yu Huang, Michael Barton, Paul Keall
PURPOSE: The purpose of this article is to present the first imaging experiments to demonstrate the functional equivalence between a conventional rotational gantry and a fixed-beam imaging geometry, and the feasibility of an iterative image-reconstruction technique under gravitational deformation. METHODS AND MATERIALS: Experiments were performed using an Elekta Axesse with Agility MLC and XVI, a custom-built rotating phantom stage, a Catphan QA phantom, and a porcine heart...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740772/relationship-between-keloid-formation-and-yap-taz-signaling
#10
Noriko Aramaki-Hattori, Keisuke Okabe, Mariko Hamada, Tamae Takato, Kazuo Kishi
YAP (yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) are part of a classical pathway that controls contact inhibition in the Hippo pathway. YAP and TAZ were recently reported to act as nuclear relays of mechanical signals that communicate extracellular matrix rigidity and cell shape. However, the role of YAP/TAZ signaling in keloid formation is unclear. Here, we used immunohistochemistry to investigate YAP/TAZ expression in keloid and nonaffected lesions. YAP/TAZ expression in keloid fibroblasts had a greater tendency to localize to the nucleus relative to that seen in fibroblasts from unaffected tissues...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28740718/papillary-muscle-approximation-in-mitral-valve-repair-for-secondary-mr
#11
REVIEW
Francesco Nappi, Cristiano Spadaccio, Massimo Chello, Christos G Mihos
Ischemic mitral regurgitation (IMR) is a complex disorder occurring after a myocardial infarction and affecting both the mitral valvular and subvalvular apparati. Several abnormalities can be detected in IMR as annular dilatation, leaflet tethering with impaired coaptation and papillary muscle (PM) displacement along a posterior, apical or lateral vectors. Treatments available include, beside myocardial revascularization, mitral-valve repair or chordal-sparing replacement. Repair is normally achieved downsizing the mitral valve annulus with a rigid or semirigid ring...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28738732/comparative-evaluation-of-physical-characteristics-of-different-inflatable-penile-prostheses
#12
Paholo Barboglio Romo, Harshitha Prakash Chikkatur, Sahana Beldona, Yooni Yi, Tim M Bruns, Bahaa S Malaeb
OBJECTIVE: The aim of this study was to describe and evaluate existing inflatable penile prostheses (IPPs) in an independent laboratory setting. MATERIALS AND METHODS: New IPPs were obtained from two manufacturers: American Medical Systems (AMS) and Coloplast. The AMS 700™ LGX (18 cm), CX (18 cm) and CXR (14 cm), and the Coloplast Titan(®) Touch (18 cm) and Titan Narrow (14 cm) were investigated. Internal pressure, length and girth of the cylinders were measured at 2 ml increments...
July 25, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28738568/novel-imidazole-fluorescent-poly-ionic-liquid-nanoparticles-for-selective-and-sensitive-determination-of-pyrogallol
#13
Zhouyang Li, Yiwen Yang, Yanbo Zeng, Jianbo Wang, Haiqing Liu, Longhua Guo, Lei Li
This paper reports novel imidazole fluorescent poly(ionic liquid) nanoparticles (FPILNs) of poly(1-[(4-methyphenyl)methyl]-3-vinyl-imidazolium bromide (poly([MVI]Br) for selective and sensitive determination of pyrogallol. An imidazole ionic liquid of 1-[(4-methyphenyl)methyl]-3-vinyl-imidazolium bromide ([MVI]Br) was synthesized and used as the only monomer to obtain poly([MVI]Br) possessing phenyl fluorophores using a radical polymerization technique. The obtained poly([MVI]Br) can form nanoparticles in water...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28737906/role-of-the-protein-dimeric-interface-in-allosteric-inhibition-of-n-acetyl-aspartate-hydrolysis-by-human-aspartoacylase
#14
Ekaterina D Kots, Sofya V Lushchekina, Sergey D Varfolomeev, Alexander V Nemukhin
The results of molecular modeling suggest a mechanism of allosteric inhibition upon hydrolysis of N-acetyl-aspartate (NAA), one of the most abundant amino acid derivatives in brain, by human aspartoacylase (hAsp). Details of this reaction are important to suggest the practical ways to control the enzyme activity. Search for allosteric sites using the Allosite web server and SiteMap analysis allowed us to identify substrate binding pockets located at the interface between the subunits of the hAsp dimer molecule...
July 24, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28737555/l-shaped-septal-extension-spreader-graft-for-improvement-of-tip-symmetry-in-unilateral-cleft-lip-nose-deformities
#15
Serkan Sertel, Ioana-Irina Venara-Vulpe, François Gorostidi, Anthony de Buys Roessingh, Philippe Pasche
INTRODUCTION: The unilateral cleft lip nose is characterized by numerous complex and interdependent deformities. Secondary rhinoplasty techniques aim to correct cleft lip nose deformities by using multiple maneuvers combining septum and nasal spine medialization and alar cartilage, as well as soft tissue mobilization and repositioning. Moreover, cartilage grafting is frequently used to restore adequate tip projection and nasal symmetry. We present a technique of cartilage grafting commonly used in noncleft rhinoplasties that we modified for cases of moderate cleft lip nose deformities...
July 22, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28736889/fast-adsorption-of-soft-hydrogel-microspheres-on-solid-surfaces-in-aqueous-solution
#16
Shusuke Matsui, Takuma Kureha, Seina Hiroshige, Mikihiro Shibata, Takayuki Uchihashi, Daisuke Suzuki
The real-time adsorption behavior of polymeric colloidal microspheres onto solid surfaces in aqueous solution was visualized for the first time using high-speed atomic force microscopy (HS-AFM) in order to reveal how the softness of the microspheres affects their dynamic adsorption. Studies that focus on the deformability of microspheres upon dynamic adsorption have not yet been reported, most likely on account of a lack of techniques that appropriately depict the dynamic adsorption and deformation behavior of individual microspheres at the nanoscale in real time...
July 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28736824/evaluation-of-lumazine-synthase-from-bacillus-anthracis-as-a-presentation-platform-for-polyvalent-antigen-display
#17
Yangjie Wei, Newton Wahome, Greta VanSlyke, Neal Whitaker, Prashant Kumar, Michael L Barta, Wendy L Picking, David B Volkin, Nicholas J Mantis, C Russell Middaugh
Polyvalent antigen display is an effective strategy to enhance the immunogenicity of subunit vaccines by clustering them in an array-like manner on a scaffold system. This strategy results in a higher local density of antigens, increased high avidity interactions with B cells and other antigen presenting cells, and therefore a more effective presentation of vaccine antigens. In the present study, we used lumazine synthase (LS), an icosahedral symmetry capsid derived from Bacillus anthracis, as a scaffold to present 60 copies of a linear B cell epitope (PB10) from the ricin toxin fused to the C terminus of LS via four different linkers...
July 24, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28736776/emojinet-building-a-machine-readable-sense-inventory-for-emoji
#18
Sanjaya Wijeratne, Lakshika Balasuriya, Amit Sheth, Derek Doran
Emoji are a contemporary and extremely popular way to enhance electronic communication. Without rigid semantics attached to them, emoji symbols take on different meanings based on the context of a message. Thus, like the word sense disambiguation task in natural language processing, machines also need to disambiguate the meaning or 'sense' of an emoji. In a first step toward achieving this goal, this paper presents EmojiNet, the first machine readable sense inventory for emoji. EmojiNet is a resource enabling systems to link emoji with their context-specific meaning...
November 2016: Proc Int Workshop Soc Inform
https://www.readbyqxmd.com/read/28736690/decellularization-of-human-internal-mammary-artery-biomechanical-properties-and-histopathological-evaluation
#19
Abdol-Mohammad Kajbafzadeh, Reza Khorramirouz, Seyede Maryam Kameli, Javad Hashemi, Amin Bagheri
This study undertook to create small-diameter vascular grafts and assess their structure and mechanical properties to withstand arterial implantation. Twenty samples of intact human internal mammary arteries (IMAs) were collected and decellularized using detergent-based methods. To evaluate residual cellular and extracellular matrix (ECM) components, histological analysis was performed. Moreover, collagen typing and ECM structure were analyzed by Picrosirius red and Movat's pentachrome staining. Scanning electron microscopy was also applied to assess microarchitecture of both endothelial and adventitial surfaces of native and decellularized arterial samples...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/28735836/importance-of-deformable-image-registration-and-biological-dose-summation-in-planning-of-radiotherapy-retreatments
#20
Eeva Boman, Mika Kapanen, Lyndsey Pickup, Sirpa-Liisa Lahtela
The purpose of this study is to evaluate the effect of nonrigid and fractionation-corrected dose summation on total doses in radiotherapy and to demonstrate the benefits of such dose summation on clinical decision-making for planning of retreatments. Dose summation of organs at risk (OARs) was investigated for 3 clinical cases with need of retreatment to the same site: head and neck, brain, and mediastinum. Three different summation methods over old and new radiotherapy treatment plans are presented and compared: (1) rigid raw sum with rigid registration of the planning images and direct dose summing; (2) deformable raw sum with deformable image registration and direct dose summing; and (3) deformable biological sum with deformable registration and takes into account the dose per fraction in biological manner in certain critical organs...
July 20, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
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