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https://www.readbyqxmd.com/read/27933354/-pathophysiology-diagnosis-and-treatment-of-zenker-s-diverticulum
#1
T Hussain, J T Maurer, S Lang, B A Stuck
Zenker's diverticulum occurs at the dorsal pharyngoesophageal junction through Killian's dehiscence and is caused by increased intrabolus pressure. Symptomatic disease most frequently affects male elderly patients. Primary symptom is oropharyngeal dysphagia, as well as regurgitation of undigested food, halitosis, and chronic aspiration. A barium swallow study is performed to confirm diagnosis. Treatment options for symptomatic patients include open surgery, as well as transoral rigid or flexible endoscopic procedures...
December 8, 2016: HNO
https://www.readbyqxmd.com/read/27933021/dimensions-of-compulsive-exercise-across-eating-disorder-diagnostic-subtypes-and-the-validation-of-the-spanish-version-of-the-compulsive-exercise-test
#2
Sarah Sauchelli, Jon Arcelus, Roser Granero, Susana Jiménez-Murcia, Zaida Agüera, Amparo Del Pino-Gutiérrez, Fernando Fernández-Aranda
Objectives: Compulsive exercise in eating disorders has been traditionally considered as a behavior that serves the purpose of weight/shape control. More recently, it has been postulated that there may be other factors that drive the compulsive need to exercise. This has led to the development of the Compulsive Exercise Test (CET); a self-reported questionnaire that aims to explore the cognitive-behavioral underpinnings of compulsive exercise from a multi-faceted perspective. The objectives of this study were threefold: (1) to validate the Spanish version of the CET; (2) to compare eating disorder diagnostic subtypes and a healthy control group in terms of the factors that drive compulsive exercise as defined by the CET; (3) to explore how the dimensions evaluated in the CET are associated with eating disorder symptoms and general psychopathology...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27930723/fourteen-years-of-experience-of-liver-transplantation-for-wilson-s-disease-a-report-on-107-cases-from-shiraz-iran
#3
Kamran B Lankarani, Seyed Ali Malek-Hosseini, Saman Nikeghbalian, Mohsen Dehghani, Mohammad Pourhashemi, Kourosh Kazemi, Parisa Janghorban, Maryam Akbari, Sulmaz Ghahramani, Bijan Eghtesad, Maryam Moini, Abbas Rahmi Jaberi, Alireza Shamsaifar, Siavosh Gholami, Fatemeh Rahmanian, Bita Geramizadeh
BACKGROUND AND AIM: Liver transplantation is a potential cure for liver damage from Wilson's disease but the course of neuropsychiatric manifestations after transplantation remains undetermined. MATERIAL AND METHODS: In this study, data on all patients who'd received a liver transplant for Wilson's disease at the Shiraz Organ Transplantation Center between December 2000 and March 2014 were reviewed and compared to data on a control group who'd received a liver transplant over the same period but due to other causes...
2016: PloS One
https://www.readbyqxmd.com/read/27929588/use-of-%C3%AE-cyclodextrin-tethered-cationic-polymer-based-fluorescence-enhancement-of-pyrene-and-hybridization-chain-reaction-for-the-enzyme-free-amplified-detection-of-dna
#4
Chunxia Song, Bingjie Li, Xiaohai Yang, Kemin Wang, Qing Wang, Jianbo Liu, Jin Huang
Herein, we proposed an enzyme-free strategy for the amplified detection of DNA by combining the efficient fluorescence enhancement capability of a β-cyclodextrin-tethered cationic polymer (cationic polyβ-CD) to pyrene with the amplification capability of target DNA triggered hybridization chain reaction (HCR). Cationic polyβ-CD with positive charge was synthesized. Two hairpin probes, H1 and H2, were employed in the system and the pyrene-labelled H2 was chosen as the signal unit. The pyrene attached on the sticky end of H2 was flexible and there was strong electrostatic interaction between cationic polyβ-CD and negatively-charged H2, so pyrene could easily enter the cavity of CD that is tethered on the cationic polymer, accompanied by significant fluorescence enhancement...
December 8, 2016: Analyst
https://www.readbyqxmd.com/read/27928810/the-association-of-stone-opacity-in-plain-radiography-with-percutaneous-nephrolithotomy-outcomes-and-complications
#5
Robab Maghsoudi, Masoud Etemadian, Amir Hossein Kashi, Alireza Ranjbaran
PURPOSE: To investigate the influence of stone opacity in plain radiography on stone free rate and complications ofpercutaneous nephrolithotomy (PCNL). MATERIALS AND METHODS: A number of 101 patients who underwent PCNL between July-September 2015 wereprospectively included. Stone opacity was judged on preoperative plain Kidney-Ureter-Bladder X-ray. Stone freerate was evaluated two weeks after the operation by ultrasonography and KUB. RESULTS: There were 61 patients with opaque stones and 40 patients with non-opaque stones...
December 8, 2016: Urology Journal
https://www.readbyqxmd.com/read/27928780/elective-laparoscopic-deroofing-to-treat-the-spontaneous-rupture-of-a-large-simple-liver-cyst-a-case-report
#6
Yuki Imaoka, Masahiro Ohira, Tsuyoshi Kobayashi, Seiichi Shimizu, Hiroyuki Tahara, Shintaro Kuroda, Kentaro Ide, Kohei Ishiyama, Hideki Ohdan
BACKGROUND: The spontaneous rupture of nonparasitic liver cysts (NLC) is sometimes seen in clinical practice. However, there are no guidelines that describe the optimal treatment strategy and the surgical indications for an NLC rupture due to a small number of reports. Here, we present a case who underwent elective laparoscopic deroofing to treat a spontaneously ruptured NLC that had undergone conservative treatment. CASE PRESENTATION: A 67-year-old woman was referred to our hospital for the evaluation of acute abdominal pain after the conservative treatment of an NLC at another hospital...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27928494/synthetically-tuneable-biomimetic-artificial-photosynthetic-reaction-centres-that-closely-resemble-the-natural-system-in-purple-bacteria
#7
Sai-Ho Lee, Iain M Blake, Allan G Larsen, James A McDonald, Kei Ohkubo, Shunichi Fukuzumi, Jeffrey R Reimers, Maxwell J Crossley
Porphyrin-based photosynthetic reaction centre (PRC) mimics, ZnPQ-Q2HP-C60 and MP2Q-Q2HP-C60 (M = Zn or 2H), designed to have a similar special-pair electron donor and similar charge-separation distances, redox processes and photochemical reaction rates to those in the natural PRC from purple bacteria, have been synthesised and extensive photochemical studies performed. Mechanisms of electron-transfer reactions are fully investigated using femtosecond and nanosecond transient absorption spectroscopy. In benzonitrile, all models show picosecond-timescale charge-separations and the final singlet charge-separations with the microsecond-timescale...
October 19, 2016: Chemical Science
https://www.readbyqxmd.com/read/27927988/a-complete-structural-inventory-of-the-mycobacterial-microcompartment-shell-proteins-constrains-models-of-global-architecture-and-transport
#8
Evan Mallette, Matthew S Kimber
Bacterial microcompartments are bacterial analogs of eukaryotic organelles in that they spatially segregate aspects of cellular metabolism, but do so by building not a lipid membrane but a thin polyhedral protein shell. While multiple shell protein structures are known for several microcompartment types, additional uncharacterized components complicate systematic investigations of shell architecture. We report here the structures of all four proteins proposed to form the shell of an uncharacterized microcompartment designated the Rhodococcus and Mycobacterium Microcompartment (RMM), which, along with crystal interactions and docking studies, suggests possible models for the particle's vertex and edge organization...
December 6, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27927550/strength-of-thoracic-spine-under-simulated-direct-vertebral-rotation-a%C3%A2-biomechanical-study
#9
Sean L Borkowski, Sophia N Sangiorgio, Richard E Bowen, Anthony A Scaduto, Bo He, Kathryn L Bauer, Edward Ebramzadeh
BACKGROUND: Direct vertebral rotation (DVR) has gained increasing popularity for deformity correction surgery. Despite large moments applied intraoperatively during deformity correction and failure reports including screw plow, aortic abutment, and pedicle fracture, to our knowledge, the strength of thoracic spines has been unknown. Moreover, the rotational response of thoracic spines under such large torques has been unknown. PURPOSE: Simulate DVR surgical conditions to measure torsion to failure on thoracic spines and assess surgical forces...
March 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927520/staged-anterior-release-and-posterior-instrumentation-in-correction-of%C3%A2-severe-rigid-scoliosis-cobb-angle-100-degrees
#10
Pankaj Kandwal, Ankur Goswami, G Vijayaraghavan, K R Subhash, Ashok Jaryal, B N Upendra, Arvind Jayaswal
PURPOSE: Severe rigid curves present a big challenge to the treating spine surgeon. We evaluated the outcome of staged anterior release and posterior instrumentation for rigid scoliosis. METHODS: Twenty-one patients with an average age of 14.4 years (range 11-17) having a rounded severe rigid scoliosis (Cobb angle >100 degrees) underwent surgical correction. Six patients had congenital scoliosis, 13 idiopathic scoliosis, and 2 syndromic. All patients underwent anterior release in Stage I with one or more Ponte osteotomies and in Stage II with all pedicle screw instrumentation, and 13 of the patients underwent an asymmetric pedicle subtraction osteotomy at the apex...
July 2016: Spine Deformity
https://www.readbyqxmd.com/read/27927258/a-case-of-tetanus-secondary-to-an-odontogenic-infection
#11
Majid Darraj, James Stone, Yoav Keynan, Kristjan Thompson, Carolyn Snider
Tetanus is a life-threatening clinical syndrome that commonly presents with muscular spasms, rigidity, and autonomic instability. It is considered rare in industrialized countries, and tetanus occurring secondary to dental abscesses, procedures, or infections has been infrequently reported. We describe the case of a patient inadequately immunized for tetanus, who presented to the emergency department with muscular spasms, rigidity, and autonomic instability in the setting of an odontogenic infection. A clinical diagnosis of tetanus was made and subsequently managed successfully...
December 8, 2016: CJEM
https://www.readbyqxmd.com/read/27926874/multivalent-histone-and-dna-engagement-by-a-phd-brd-pwwp-triple-reader-cassette-recruits-zmynd8-to-k14ac-rich-chromatin
#12
Pavel Savitsky, Tobias Krojer, Takao Fujisawa, Jean-Philippe Lambert, Sarah Picaud, Chen-Yi Wang, Erin K Shanle, Krzysztof Krajewski, Hans Friedrichsen, Alexander Kanapin, Colin Goding, Matthieu Schapira, Anastasia Samsonova, Brian D Strahl, Anne-Claude Gingras, Panagis Filippakopoulos
Elucidation of interactions involving DNA and histone post-translational-modifications (PTMs) is essential for providing insights into complex biological functions. Reader assemblies connected by flexible linkages facilitate avidity and increase affinity; however, little is known about the contribution to the recognition process of multiple PTMs because of rigidity in the absence of conformational flexibility. Here, we resolve the crystal structure of the triple reader module (PHD-BRD-PWWP) of ZMYND8, which forms a stable unit capable of simultaneously recognizing multiple histone PTMs while presenting a charged platform for association with DNA...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27926840/calcium-dependent-structural-dynamics-of-a-spin-labeled-ryr-peptide-bound-to-calmodulin
#13
Cheng Her, Jesse E McCaffrey, David D Thomas, Christine B Karim
We have used chemical synthesis, electron paramagnetic resonance (EPR), and circular dichroism to detect and analyze the structural dynamics of a ryanodine receptor (RyR) peptide bound to calmodulin (CaM). The skeletal muscle calcium release channel RyR1 is activated by Ca(2+)-free CaM and inhibited by Ca(2+)-bound CaM. To probe the structural mechanism for this regulation, wild-type RyRp and four spin-labeled derivatives were synthesized, each containing the nitroxide probe 2,2,6,6-tetramethyl-piperidine-1-oxyl-4-amino-4-carboxylic acid substituted for a single amino acid...
December 6, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27926672/mechanisms-predisposing-factors-and-prognosis-of-intra-operative-vertebral-subluxation-during-pedicle-subtraction-osteotomy-in-surgical-correction-of-thoracolumbar-kyphosis-secondary-to-ankylosing-spondylitis
#14
Bang-Ping Qian, Sai-Hu Mao, Jun Jiang, Bin Wang, Yong Qiu
STUDY DESIGN: A retrospective study. OBJECTIVE: To analyze the mechanisms, predisposing factors and prognosis of the intraoperative vertebral subluxation (VS) during pedicle subtraction osteotomy (PSO) for thoracolumbar kyphosis secondary to ankylosing spondylitis (AS). SUMMARY OF BACKGROUND DATA: VS is one of the most daunting challenges that surgeons encounter during PSO closure, especially in AS patients with ankylosed and mostly osteoporotic spine...
December 6, 2016: Spine
https://www.readbyqxmd.com/read/27925755/collective-molecular-superrotation-a-model-for-extremely-flexible-molecules-applied-to-protonated-methane
#15
Hanno Schmiedt, Per Jensen, Stephan Schlemmer
The concept of molecular structure is traditionally considered to be virtually fundamental. However, it breaks down in extremely flexible molecules, whose dynamics are governed by large-amplitude motions. For the dynamics of molecules with free internal rotations, we therefore propose a five-dimensional rigid rotor model, with states characterized by two generalized angular momentum quantum numbers and a rotational constant B. The quantum numbers characterize a 5D angular-momentum vector, super-j, which describes collective rotations that involve both the internal and the overall rotation...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925324/the-delicate-balance-of-preorganisation-and-adaptability-in-multiply-bonded-host-guest-complexes
#16
Larissa K S von Krbek, Andreas J Achazi, Stefan Schoder, Marius Gaedke, Tobias Biberger, Beate Paulus, Christoph A Schalley
Rigidity and preorganisation are believed to be required for high affinity in multiply bonded supramolecular complexes as they help reducing the entropic penalty of the binding event. This comes at the price that such rigid complexes are sensitive to small geometric mismatches. In marked contrast, nature uses more flexible building blocks. Thus, one might consider putting the rigidity-high affinity notion to the test. Multivalent crown/ammonium complexes are ideal for this purpose as the monovalent interaction is well understood...
December 7, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27924976/simple-and-high-yield-access-to-octafunctional-azido-amine-and-urea-group-bearing-cubic-spherosilicates
#17
Sandra Schäfer, Guido Kickelbick
Spherosilicates and polyhedral oligomeric silsesquioxanes represent unique well-defined rigid building blocks for molecular and hybrid materials. Drawbacks in their synthesis are often low yields and the restricted presence of functional groups either based on incomplete transformation of all corners or the reactivity of the functional groups. Particularly amine-functionalization reveals some synthetic challenges. In this study we report the synthesis of a new class of octafunctionalized hydrogen bond forming spherosilicates via a facile route based on octabromo alkyl functionalized cubic spherosilicates...
December 7, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27924273/molecular-dynamics-analysis-to-evaluate-docking-pose-prediction
#18
Takako Sakano, Md Iqbal Mahamood, Takefumi Yamashita, Hideaki Fujitani
The accurate prediction of a ligand-protein complex structure is important for computer-assisted drug development. Although many docking methods have been developed over the last three decades, the success of binding structure prediction remains greatly limited. The purpose of this study was to demonstrate the usefulness of molecular dynamics (MD) simulation in assessing a docking pose predicted using a docking program. If the predicted pose is not unstable in an aqueous environment, MD simulation equilibrates the system and removes the ligand from the predicted position...
2016: Biophysics and Physicobiology
https://www.readbyqxmd.com/read/27924264/specificity-of-broad-protein-interaction-surfaces-for-proteins-with-multiple-binding-partners
#19
Nobuyuki Uchikoga, Yuri Matsuzaki, Masahito Ohue, Yutaka Akiyama
Analysis of protein-protein interaction networks has revealed the presence of proteins with multiple interaction ligand proteins, such as hub proteins. For such proteins, multiple ligands would be predicted as interacting partners when predicting all-to-all protein-protein interactions (PPIs). In this work, to obtain a better understanding of PPI mechanisms, we focused on protein interaction surfaces, which differ between protein pairs. We then performed rigid-body docking to obtain information of interfaces of a set of decoy structures, which include many possible interaction surfaces between a certain protein pair...
2016: Biophysics and Physicobiology
https://www.readbyqxmd.com/read/27924263/determination-of-locked-interfaces-in-biomolecular-complexes-using-haptimol_rd
#20
Georgios Iakovou, Stephen Laycock, Steven Hayward
Interactive haptics-assisted docking provides a virtual environment for the study of molecular complex formation. It enables the user to interact with the virtual molecules, experience the interaction forces via their sense of touch, and gain insights about the docking process itself. Here we use a recently developed haptics software tool, Haptimol_RD, for the rigid docking of protein subunits to form complexes. Dimers, both homo and hetero, are loaded into the software with their subunits separated in space for the purpose of assessing whether they can be brought back into the correct docking pose via rigid-body movements...
2016: Biophysics and Physicobiology
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