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https://www.readbyqxmd.com/read/28087891/physical-activity-and-exercise-for-chronic-pain-in-adults-an-overview-of-cochrane-reviews
#1
REVIEW
Louise J Geneen, R Andrew Moore, Clare Clarke, Denis Martin, Lesley A Colvin, Blair H Smith
BACKGROUND: Chronic pain is defined as pain lasting beyond normal tissue healing time, generally taken to be 12 weeks. It contributes to disability, anxiety, depression, sleep disturbances, poor quality of life, and healthcare costs. Chronic pain has a weighted mean prevalence in adults of 20%.For many years, the treatment choice for chronic pain included recommendations for rest and inactivity. However, exercise may have specific benefits in reducing the severity of chronic pain, as well as more general benefits associated with improved overall physical and mental health, and physical functioning...
January 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28087654/effects-of-external-strain-on-the-regulation-of-microtubule-sliding-induced-by-outer-arm-dynein-of-sea-urchin-sperm-flagella
#2
Hiroshi Yoke, Chikako Shingyoji
Oscillatory bending movement of eukaryotic flagella is powered by orchestrated activity of dynein motor proteins that hydrolyze ATP and produce microtubule sliding. Although the ATP concentration within a flagellum is kept uniform at a few mmol l(-1) level, sliding activities of dyneins are dynamically coordinated along the flagellum in accordance with the phase of bending waves. Thus, at the organellar level the dynein not only generates force for bending but also modulates its motile activity by responding to bending of the flagellum...
January 13, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28087640/flexible-sigmoidoscopy-screening-for-colorectal-cancer
#3
EDITORIAL
Ulrike Haug
No abstract text is available yet for this article.
January 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28087621/the-hook-region-of-voltage-gated-ca2-channel-%C3%AE-subunits-senses-and-transmits-pip2-signals-to-the-gate
#4
Cheon-Gyu Park, Yongsoo Park, Byung-Chang Suh
The β subunit of voltage-gated Ca(2+) (CaV) channels plays an important role in regulating gating of the α1 pore-forming subunit and its regulation by phosphatidylinositol 4,5-bisphosphate (PIP2). Subcellular localization of the CaV β subunit is critical for this effect; N-terminal-dependent membrane targeting of the β subunit slows inactivation and decreases PIP2 sensitivity. Here, we provide evidence that the HOOK region of the β subunit plays an important role in the regulation of CaV biophysics. Based on amino acid composition, we broadly divide the HOOK region into three domains: S (polyserine), A (polyacidic), and B (polybasic)...
January 13, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28087510/effectiveness-of-flexible-sigmoidoscopy-screening-in-men-and-women-and-different-age-groups-pooled-analysis-of-randomised-trials
#5
Øyvind Holme, Robert E Schoen, Carlo Senore, Nereo Segnan, Geir Hoff, Magnus Løberg, Michael Bretthauer, Hans-Olov Adami, Mette Kalager
OBJECTIVE:  To compare the effectiveness of flexible sigmoidoscopy in screening for colorectal cancer by patient sex and age. DESIGN:  Pooled analysis of randomised trials (the US Prostate, Lung, Colorectal and Ovarian cancer screening trial (PLCO), the Italian Screening for Colon and Rectum trial (SCORE), and the Norwegian Colorectal Cancer Prevention trial (NORCCAP)). DATA SOURCES:  Aggregated data were pooled from each randomised trial on incidence of colorectal cancer and mortality stratified by sex, age at screening, and colon subsite (distal v proximal)...
January 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28086965/probabilistic-liver-atlas-construction
#6
Esther Dura, Juan Domingo, Guillermo Ayala, Luis Marti-Bonmati, E Goceri
BACKGROUND: Anatomical atlases are 3D volumes or shapes representing an organ or structure of the human body. They contain either the prototypical shape of the object of interest together with other shapes representing its statistical variations (statistical atlas) or a probability map of belonging to the object (probabilistic atlas). Probabilistic atlases are mostly built with simple estimations only involving the data at each spatial location. RESULTS: A new method for probabilistic atlas construction that uses a generalized linear model is proposed...
January 13, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28086869/evaluation-of-an-aged-care-nurse-practitioner-service-quality-of-care-within-a-residential-aged-care-facility-hospital-avoidance-service
#7
Trudy Dwyer, Alison Craswell, Dolene Rossi, Darren Holzberger
BACKGROUND: Reducing avoidable hospitialisation of aged care facility (ACF) residents can improve the resident experience and their health outcomes. Consequently many variations of hospital avoidance (HA) programs continue to evolve. Nurse practitioners (NP) with expertise in aged care have the potential to make a unique contribution to hospital avoidance programs. However, little attention has been dedicated to service evaluation of this model and the quality of care provided. The purpose of this study was to evaluate the quality of an aged care NP model of care situated within a HA service in a regional area of Australia...
January 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28081297/first-trimester-noninvasive-fetal-rhd-genotyping-using-maternal-dried-blood-spots
#8
Yali Xiong, Stacey Jeronis, Barbara Hoffman, Dan A Liebermann, Ossie Geifman-Holtzman
OBJECTIVE: This study was aimed to evaluate whether maternal dried blood spots (DBS) could be a potential source for the non-invasive fetal RHD genotyping, serving as a combined one-step test for both the First Trimester Screen and the fetal RHD genotyping. METHOD: Both the DBS and the peripheral blood samples from nineteen RhD-negative pregnant women were obtained during the First Trimester Screen. DNA was extracted and Sequential Real-time PCRs were performed to determine the fetal RHD genotypes...
January 12, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28081157/simultaneous-quantitative-mri-mapping-of-t1-t2-and-magnetic-susceptibility-with-multi-echo-mp2rage
#9
Riccardo Metere, Tobias Kober, Harald E Möller, Andreas Schäfer
The knowledge of relaxation times is essential for understanding the biophysical mechanisms underlying contrast in magnetic resonance imaging. Quantitative experiments, while offering major advantages in terms of reproducibility, may benefit from simultaneous acquisitions. In this work, we demonstrate the possibility of simultaneously recording relaxation-time and susceptibility maps with a prototype Multi-Echo (ME) Magnetization-Prepared 2 RApid Gradient Echoes (MP2RAGE) sequence. T1 maps can be obtained using the MP2RAGE sequence, which is relatively insensitive to inhomogeneities of the radio-frequency transmit field, [Formula: see text]...
2017: PloS One
https://www.readbyqxmd.com/read/28081084/tailoring-supercontinuum-generation-beyond-2%C3%A2-%C3%A2-%C3%AE-m-in-step-index-tellurite-fibers
#10
Clement Strutynski, Paul Froidevaux, Frédéric Désévédavy, Jean-Charles Jules, Grégory Gadret, Abdelkrim Bendahmane, Karol Tarnowski, Bertrand Kibler, Frédéric Smektala
We report numerical and experimental demonstrations of flexible group-velocity dispersion regimes in step-index tellurite fibers by fine control of the fiber core diameter. Our simple fiber design allowed us to explore various nonlinear propagation regimes beyond 2 μm, which involved careful control of four-wave mixing processes. Combined with the recent development of 2 μm fiber lasers, we present an easy way to tailor supercontinuum generation and related coherence features in the high-demand 1.5-3.5 μm spectral region...
January 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28081070/second-harmonic-generation-via-femtosecond-laser-fabrication-of-poled-quasi-phase-matched-waveguides-in-fused-silica
#11
Jason C Ng, Peter R Herman, Li Qian
Second harmonic generation (SHG) is demonstrated in femtosecond laser written waveguides in fused silica through a combination of thermal poling and laser-based quasi-phase-matching (QPM) techniques. Quasi-phase-matching was controlled by the periodic erasure of induced nonlinearity through femtosecond laser erasure. A maximum SHG conversion efficiency of 6.6±0.5×10<sup>-5</sup>%/W is reported for the fundamental wavelength of 1552.8 nm with a phase-matching bandwidth of 4.4 nm for a 10.0 mm long waveguide...
January 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28081016/graphene-as-a-flexible-template-for-controlling-magnetic-interactions-between-metal-atoms
#12
Sungwoo Lee, Dongwook Kim, Alex W Robertson, Euijoon Yoon, Suklyun Hong, Jisoon Ihm, Jaejun Yu, Jamie H Warner, Gun-Do Lee
Metal-doped graphene produces magnetic moments that have potential application in spintronics. Here we use density function theory computational methods to show how the magnetic interaction between metal atoms doped in graphene can be controlled by the degree of flexure in a graphene membrane. Bending graphene by flexing causes the distance between two substitutional Fe atoms covalently bonded in graphene to gradually increase and these results in the magnetic moment disappearing at a critical strain value...
January 12, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28080261/performance-of-hispanics-and-non-hispanic-whites-on-the-nih-toolbox-cognition-battery-the-roles-of-ethnicity-and-language-backgrounds
#13
Ilse Flores, Kaitlin B Casaletto, Maria J Marquine, Anya Umlauf, David J Moore, Dan Mungas, Richard C Gershon, Jennifer L Beaumont, Robert K Heaton
OBJECTIVE: This study examined the influence of Hispanic ethnicity and language/cultural background on performance on the NIH Toolbox Cognition Battery (NIHTB-CB). METHOD: Participants included healthy, primarily English-speaking Hispanic (n = 93; Hispanic-English), primarily Spanish-speaking Hispanic (n = 93; Hispanic-Spanish), and English speaking Non-Hispanic white (n = 93; NH white) adults matched on age, sex, and education levels. All participants were in the NIH Toolbox national norming project and completed the Fluid and Crystallized components of the NIHTB-CB...
January 12, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28080111/generalized-movement-representation-in-haptic-perception
#14
Lucile Dupin, Vincent Hayward, Mark Wexler
The extraction of spatial information by touch often involves exploratory movements, with tactile and kinesthetic signals combined to construct a spatial haptic percept. However, the body has many tactile sensory surfaces that can move independently, giving rise to the source binding problem: when there are multiple tactile signals originating from sensory surfaces with multiple movements, are the tactile and kinesthetic signals bound to one another? We studied haptic signal combination by applying the tactile signal to a stationary fingertip while another body part (the other hand or a foot) or a visual target moves, and using a task that can only be done if the tactile and kinesthetic signals are combined...
January 12, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28080078/what-to-do-when-scalar-invariance-fails-the-extended-alignment-method-for-multi-group-factor-analysis-comparison-of-latent-means-across-many-groups
#15
Herbert W Marsh, Jiesi Guo, Philip D Parker, Benjamin Nagengast, Tihomir Asparouhov, Bengt Muthén, Theresa Dicke
Scalar invariance is an unachievable ideal that in practice can only be approximated; often using potentially questionable approaches such as partial invariance based on a stepwise selection of parameter estimates with large modification indices. Study 1 demonstrates an extension of the power and flexibility of the alignment approach for comparing latent factor means in large-scale studies (30 OECD countries, 8 factors, 44 items, N = 249,840), for which scalar invariance is typically not supported in the traditional confirmatory factor analysis approach to measurement invariance (CFA-MI)...
January 12, 2017: Psychological Methods
https://www.readbyqxmd.com/read/28080064/collective-excitations-in-protein-as-a-measure-of-balance-between-its-softness-and-rigidity
#16
Utsab Raj Shrestha, Debsindhu Bhowmik, Kurt William Van Delinder, Eugene Mamontov, Hugh M O'Neill, Qiu Zhang, Ahmet Alatas, Xiang-Qiang Chu
In this article, we elucidate the protein activity from the perspective of protein softness and flexibility by studying the collective phonon-like excitations in a globular protein, human serum albumin (HSA) and taking advantage of the state-of-the-art inelastic X-ray scattering (IXS) technique. Such excitations demonstrate that the protein becomes softer upon thermal denaturation due to disruption of weak non-covalent bonds. On the other hand, no significant change in the local excitations is detected in ligand- (drugs) bound HSA compared to the ligand-free HSA...
January 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28080052/mechanochemical-tuning-of-pyrene-absorption-spectrum-using-force-probes
#17
Miguel Angel Fernández-González, Daniel Rivero, Cristina García-Iriepa, Diego Sampedro, Luis Manuel Frutos
Control of absorption spectra in chromophores is a fundamental aspect of many photochemical and photophysical processes as it constitutes the first step of the global photoinduced process. Here we explore the use of mechanical forces to modulate the light absorption process. Specifically, we develop a computational formalism for determining the type of mechanical forces permitting a global tuning of the absorption spectrum. This control extends to the excitation wavelength, absorption bands overlap and oscillator strength...
January 12, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28080027/asymmetric-pentagonal-metal-meshes-for-flexible-transparent-electrodes-and-heaters
#18
Daniel Lordan, Micheal Burke, Mary Manning, Alfonso Martin, Andreas Amann, Dan O' Connell, Richard Murphy, Colin Lyons, Aidan J Quinn
Metal meshes have emerged as an important class of flexible transparent electrodes. We report on the characteristics of a new class of asymmetric meshes, tiled using a recently-discovered family of pentagons. Micron-scale meshes were fabricated on flexible polyethylene terephthalate substrates via optical lithography, metal evaporation (Ti 10 nm, Pt 50 nm) and lift-off. Three different designs were assessed, each with the same tessellation pattern and linewidth (5 µm), but with different sizes of the fundamental pentagonal unit...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28080019/controlled-growth-of-metal-organic-framework-on-upconversion-nanocrystals-for-nir-enhanced-photocatalysis
#19
Mohua Li, Zhenjian Zheng, Yangqiong Zheng, Cao Cui, Chunxia Li, Zhengquan Li
Development of MOF-based photocatalysts is intriguing research due to their structural flexibility and tremendous catalytic sites, whereas most MOFs only can take use of UV/visible light and lack of response to NIR light. Herein, we present a facile approach to integrate upconversion nanoparticles (UCNPs) with MOF to build a NIR-responsive composite photocatalyst. The MOF shell with controllable thickness can be grown on the UCNPs, thus exhibiting tunable photocatalytic activities under NIR irradiation. Furthermore, we extend visible absorption of the MOF shell by adding -NH2 groups so that the composite photocatalysts have a better utilization of UC emissions and sunlight to improve their activities...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28079727/how-supervisor-experience-influences-trust-supervision-and-trainee-learning-a-qualitative-study
#20
Leslie Sheu, Jennifer R Kogan, Karen E Hauer
PURPOSE: Appropriate trust and supervision facilitate trainees' growth toward unsupervised practice. The authors investigated how supervisor experience influences trust, supervision, and subsequently trainee learning. METHOD: In a two-phase qualitative inductive content analysis, phase one entailed reviewing 44 internal medicine resident and attending supervisor interviews from two institutions (July 2013 to September 2014) for themes on how supervisor experience influences trust and supervision...
January 10, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
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