keyword
MENU ▼
Read by QxMD icon Read
search

flexible

keyword
https://www.readbyqxmd.com/read/28231526/enhanced-identification-of-%C3%AE-lactamases-and-its-classes-using-sequence-physicochemical-and-evolutionary-information-with-sequence-feature-characterization-of-the-classes
#1
Abhigyan Nath, S Karthikeyan
β-lactamases provides one of the most successful means of evading the therapeutic effects of β lactam class of antibiotics by many gram positive and gram negative bacteria. On the basis of sequence identity, β-lactamases have been identified into four distinct classes- A, B, C and D. The classes A, C and D are the serine β-lactamases and class B is the metallo-lactamse. In the present study, we developed a two stage cascade classification system. The first-stage performs the classification of β-lactamases from non-β-lactamases and the second-stage performs the further classification of β-lactamases into four different β-lactamase classes...
February 14, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28231524/discovery-of-novel-cdk8-inhibitors-using-multiple-crystal-structures-in-docking-based-virtual-screening
#2
Taijin Wang, Zhuang Yang, Yongguang Zhang, Wei Yan, Fang Wang, Linhong He, Yuanyuan Zhou, Lijuan Chen
The cyclin dependent kinase CDK8, along with Med12 and Med13, form the kinase module of the Mediator complex. CDK8 expression associates with the activation of β-catenin in colon and gastric cancers. Herein, we applied docking-based virtual screening (VS) using the multiple crystal structures to identify several potent CDK8 inhibitors. The appropriate use of multiple crystal structures obtained a better enrichment of CDK8 conformations to cope with the protein flexibility. Later on, the 2D similarity search was used to find the derivatives of the high inhibitory CDK8 inhibitors we discovered by VS...
February 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28231428/facile-and-reliable-in-situ-polymerization-of-poly-ethyl-cyanoacrylate-based-polymer-electrolytes-towards-flexible-lithium-batteries
#3
Yanyan Cui, Jingchao Chai, Huiping Du, Yulong Duan, Guangwen Xie, Zhihong Liu, Guanglei Cui
ABSTRACT:Polycyanoacrylate is a very promising matrix for polymer electrolyte,which possesses advantages of strong binding and high electrochemical stability owing to the functional nitrile groups. Herein, a facile and reliable in-situ polymerization strategy of poly(ethyl cyanoacrylate) (PECA) based gel polymer electrolytes (GPE) via a high efficient anionic polymerization was introduced consisting of PECA and 4 M LiClO4 in carbonate solvents. The in-situ polymerized PECA gel polymer electrolyte achieved an excellent ionic conductivity (2...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28231413/metabolic-chemical-reporters-of-glycans-exhibit-cell-type-selective-metabolism-and-glycoprotein-labeling
#4
Anna R Batt, Balyn W Zaro, Marisol X Navarro, Matthew Robert Pratt
Since the pioneering work by Reutter and co-workers that demonstrated structural flexibility in the carbohydrate biosynthesis and glycosylation pathways, many different labs have used unnatural monosaccharide analogs to perform glycan engineering on the surface of living cells. A subset of these unnatural monosaccharides contain bioorthogonal groups that enable the selective installation of visualization or enrichment tags. These metabolic chemical reporters (MCRs) have proven to be powerful for the unbiased identification of glycoproteins; however they do have certain limitations...
February 23, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28231333/molecular-mechanisms-of-cooperative-binding-of-transcription-factors-runx1-cbf%C3%AE-ets1-on-the-tcr%C3%AE-gene-enhancer
#5
Kota Kasahara, Masaaki Shiina, Ikuo Fukuda, Kazuhiro Ogata, Haruki Nakamura
Ets1 is an essential transcription factor (TF) for several important physiological processes, including cell proliferation and differentiation. Its recognition of the enhancer region of the TCRα gene is enhanced by the cooperative binding of the Runx1-CBFβ heterodimer, with the cancelation of phosphorylation-dependent autoinhibition. The detailed mechanism of this interesting cooperativity between Ets1 and the Runx1-CBFβ heterodimer is still largely unclear. Here, we investigated the molecular mechanisms of this cooperativity, by using molecular dynamics simulations...
2017: PloS One
https://www.readbyqxmd.com/read/28231010/generation-of-anisotropic-massless-dirac-fermions-and-asymmetric-klein-tunneling-in-few-layer-black-phosphorus-superlattices
#6
Zhenglu Li, Ting Cao, Meng Wu, Steven G Louie
Artificial lattices have been employed in a broad range of two-dimensional systems, including those with electrons, atoms and photons, in the quest for massless Dirac fermions with high flexibility and controllability. Establishing triangular or hexagonal symmetry, from periodically patterned molecule assembly or electrostatic gating as well as from moiré pattern induced by substrate, has produced electronic states with linear dispersions from two-dimensional electron gas (2DEG) residing in semiconductors, metals and graphene...
February 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28231000/ion-gated-gas-separation-through-porous-graphene
#7
Ziqi Tian, Shannon M Mahurin, Sheng Dai, De-En Jiang
Porous graphene holds great promise as a one-atom-thin, high-permeance membrane for gas separation, but to precisely control the pore size down to three to five angstroms proves challenging. Here we propose an ion-gated graphene membrane comprising a monolayer of ionic liquid coated porous graphene to dynamically modulate the pore size to achieve selective gas separation. This approach enables the otherwise non-selective large pores on the order of 1 nm in size to be selective for gases whose diameters range from three to four angstroms...
February 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28230977/extracellular-self-assembly-of-functional-and-tunable-protein-conjugates-from-bacillus-subtilis
#8
Charlie Gilbert, Mark Howarth, Colin R Harwood, Tom Ellis
The ability to stably and specifically conjugate recombinant proteins to one another is a powerful approach for engineering multifunctional enzymes, protein therapeutics and novel biological materials. While many of these applications have been illustrated through in vitro and in vivo intracellular protein conjugation methods, extracellular self-assembly of protein conjugates offers unique advantages: simplifying purification, reducing toxicity and burden, and enabling tunability. Exploiting the recently described SpyTag-SpyCatcher system, we describe here how enzymes and structural proteins can be genetically-encoded to covalently conjugate in culture media following programmable secretion from Bacillus subtilis...
February 23, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28230918/single-crystal-flexible-electronics-enabled-by-3d-spalling
#9
Ning Li, Stephen Bedell, Huan Hu, Shu-Jen Han, Xiao Hu Liu, Katherine Saenger, Devendra Sadana
Flexible and stretchable electronics are becoming increasingly important in many emerging applications. Due to the outstanding electrical properties of single crystal semiconductors, there is great interest in releasing single crystal thin films and fabricating flexible electronics with these conventionally rigid materials. In this study the authors report a universal single crystal layer release process, called "3D spalling," extending beyond prior art. In contrast to the conventional way of removing blanket layers from their substrates, the new process reported here enables 3D control over the shape and thickness of the removed regions, allowing direct formation of arbitrarily shaped structures of released film and locally specified thickness for each region...
February 23, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28230914/decorating-waste-cloth-via-industrial-wastewater-for-tube-type-flexible-and-wearable-sodium-ion-batteries
#10
Yun-Hai Zhu, Shuang Yuan, Di Bao, Yan-Bin Yin, Hai-Xia Zhong, Xin-Bo Zhang, Jun-Min Yan, Qing Jiang
To turn waste into treasure, a facile and cost-effective strategy is developed to revive electroless nickel plating wastewater and cotton-textile waste toward a novel electrode substrate. Based on the substrate, a binder-free PB@GO@NTC electrode is obtained, which exhibits superior electrochemical performance. Moreover, for the first time, a novel tube-type flexible and wearable sodium-ion battery is successfully fabricated.
February 23, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28230862/inactivation-of-lsd1-triggers-senescence-in-trophoblast-stem-cells-by-induction-of-sirt4
#11
Josefina Castex, Dominica Willmann, Toufike Kanouni, Laura Arrigoni, Yan Li, Marcel Friedrich, Michael Schleicher, Simon Wöhrle, Mark Pearson, Norbert Kraut, Michaël Méret, Thomas Manke, Eric Metzger, Roland Schüle, Thomas Günther
Coordination of energy metabolism is essential for homeostasis of stem cells, whereas an imbalance in energy homeostasis causes disease and accelerated aging. Here we show that deletion or enzymatic inactivation of lysine-specific demethylase 1 (Lsd1) triggers senescence in trophoblast stem cells (TSCs). Genome-wide transcriptional profiling of TSCs following Lsd1 inhibition shows gene set enrichment of aging and metabolic pathways. Consistently, global metabolomic and phenotypic analyses disclose an unbalanced redox status, decreased glutamine anaplerosis and mitochondrial function...
February 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28230808/genome-sequence-of-rhodoferax-antarcticus-ant-br-t-a-psychrophilic-purple-nonsulfur-bacterium-from-an-antarctic-microbial-mat
#12
Jennifer M Baker, Carli J Riester, Blair M Skinner, Austin W Newell, Wesley D Swingley, Michael T Madigan, Deborah O Jung, Marie Asao, Min Chen, Patrick C Loughlin, Hao Pan, Yuankui Lin, Yaqiong Li, Jacob Shaw, Mindy Prado, Chris Sherman, Joseph Kuo-Hsiang Tang, Robert E Blankenship, Tingting Zhao, Jeffrey W Touchman, W Matthew Sattley
Rhodoferax antarcticus is an Antarctic purple nonsulfur bacterium and the only characterized anoxygenic phototroph that grows best below 20 °C. We present here a high-quality draft genome of Rfx. antarcticus strain ANT.BR(T), isolated from an Antarctic microbial mat. The circular chromosome (3.8 Mbp) of Rfx. antarcticus has a 59.1% guanine + cytosine (GC) content and contains 4036 open reading frames. In addition, the bacterium contains a sizable plasmid (198.6 kbp, 48.4% GC with 226 open reading frames) that comprises about 5% of the total genetic content...
February 21, 2017: Microorganisms
https://www.readbyqxmd.com/read/28230528/biologically-plausible-learning-in-recurrent-neural-networks-reproduces-neural-dynamics-observed-during-cognitive-tasks
#13
Thomas Miconi
Neural activity during cognitive tasks exhibits complex dynamics that flexibly encode task-relevant variables. Chaotic recurrent networks, which spontaneously generate rich dynamics, have been proposed as a model of cortical computation during cognitive tasks. However, existing methods for training these networks are either biologically implausible, and/or require a continuous, real-time error signal to guide learning. Here we show that a biologically plausible learning rule can train such recurrent networks, guided solely by delayed, phasic rewards at the end of each trial...
February 23, 2017: ELife
https://www.readbyqxmd.com/read/28230246/functional-and-evolutionary-consequences-of-cranial-fenestration-in-birds
#14
Sander W S Gussekloo, Michael A Berthaume, Daniel R Pulaski, Irene Westbroek, Jan H Waarsing, Robin Heinen, Ian R Grosse, Elizabeth R Dumont
Ostrich-like birds (Palaeognathae) show very little taxonomic diversity while their sister taxon (Neognathae) contains roughly 10000 species. The main anatomical differences between the two taxa are in the crania. Palaeognaths lack an element in the bill called the lateral bar that is present in both ancestral theropods and modern neognaths, have thin zones in the bones of the bill, and robust bony elements on the ventral surface of their crania. Here we use a combination of modelling and developmental experiments to investigate the processes that might have led to these differences...
February 23, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28230167/cytotrophoblast-not-syncytiotrophoblast-dominates-glycolysis-and-oxidative-phosphorylation-in-human-term-placenta
#15
Kevin S Kolahi, Amy M Valent, Kent L Thornburg
The syncytiotrophoblast (SCT) at the maternal-fetal interface has been presumed to be the primary driver of placental metabolism, and the underlying progenitor cytotrophoblast cells (CTB) an insignificant contributor to placental metabolic activity. However, we now show that the metabolic rate of CTB is much greater than the SCT. The oxygen consumption and extracellular acidification rate, a measure of glycolysis, are both greater in CTB than in SCT in vitro (CTB: 96 ± 16 vs SCT: 46 ± 14 pmol O2 × min(-1) × 100 ng DNA(-1), p < 0...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230153/unconventional-high-performance-laser-protection-system-based-on-dichroic-dye-doped-cholesteric-liquid-crystals
#16
Wanshu Zhang, Lanying Zhang, Xiao Liang, Le Zhou, Jiumei Xiao, Li Yu, Fasheng Li, Hui Cao, Kexuan Li, Zhou Yang, Huai Yang
High-performance and cost-effective laser protection system is of crucial importance for the rapid advance of lasers in military and civilian fields leading to severe damages of human eyes and sensitive optical devices. However, it is crucially hindered by the angle-dependent protective effect and the complex preparation process. Here we demonstrate that angle-independence, good processibility, wavelength tunability, high optical density and good visibility can be effectuated simultaneously, by embedding dichroic anthraquinone dyes in a cholesteric liquid crystal matrix...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230082/tubz-filament-assembly-dynamics-requires-the-flexible-c-terminal-tail
#17
Maria E Fuentes-Pérez, Rafael Núñez-Ramírez, Alejandro Martín-González, David Juan-Rodríguez, Oscar Llorca, Fernando Moreno-Herrero, Maria A Oliva
Cytomotive filaments are essential for the spatial organization in cells, showing a dynamic behavior based on nucleotide hydrolysis. TubZ is a tubulin-like protein that functions in extrachromosomal DNA movement within bacteria. TubZ filaments grow in a helical fashion following treadmilling or dynamic instability, although the underlying mechanism is unclear. We have unraveled the molecular basis for filament assembly and dynamics combining electron and atomic force microscopy and biochemical analyses. Our findings suggest that GTP caps retain the filament helical structure and hydrolysis triggers filament stiffening upon disassembly...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229854/-how-to-manage-with-rigour-but-flexibility-an-orthodontic-practice
#18
Edmond Binhas, Corinne Binhas
INTRODUCTION: An orthodontic office owner must understand the context and then combine logic, emotion, intuition and common sense. The productivity approach is no longer acceptable. It is necessary to combine rigour, flexibility and pragmatism. DISCUSSION: The obsessive perfectionism is ineffective. In fact, there are four ways to demonstrate a flexible determination: persevere when appropriate, win the support of your entourage, back on some decisions, appeal to the collective will...
March 2017: L' Orthodontie Française
https://www.readbyqxmd.com/read/28229518/transition-to-success-on-the-model-room-task-the-importance-of-improvements-in-working-memory
#19
Lauren E Hartstein, Neil E Berthier
Previous work has shown that children under age 3 often perform very poorly on the model room task, in which they are asked to find a hidden toy based on its location in a scale model. One prominent theory for their failure is that they lack the ability to understand the model as both a physical object and as a symbolic representation of the larger room. A hypothesized additional component is that they need to overcome weak, competing representations of where the object was on a previous trial, and where it is in the present trial, in order to succeed in their search...
February 22, 2017: Developmental Science
https://www.readbyqxmd.com/read/28229396/statistical-approaches-to-longitudinal-data-analysis-in-neurodegenerative-diseases-huntington-s-disease-as-a-model
#20
REVIEW
Tanya P Garcia, Karen Marder
Understanding the overall progression of neurodegenerative diseases is critical to the timing of therapeutic interventions and design of effective clinical trials. Disease progression can be assessed with longitudinal study designs in which outcomes are measured repeatedly over time and are assessed with respect to risk factors, either measured repeatedly or at baseline. Longitudinal data allows researchers to assess temporal disease aspects, but the analysis is complicated by complex correlation structures, irregularly spaced visits, missing data, and mixtures of time-varying and static covariate effects...
February 2017: Current Neurology and Neuroscience Reports
keyword
keyword
23431
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"