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https://www.readbyqxmd.com/read/28807279/acaricidal-activity-of-fluralaner-against-ornithodoros-moubata-and-ornithodoros-erraticus-argasid-ticks-evaluated-through-in-vitro-feeding
#1
R Pérez-Sánchez, A Oleaga
Ornithodoros erraticus and Ornithodoros moubata are argasid tick vectors that transmit severe diseases such as African swine fever and human relapsing fever. Elimination of the synanthropic populations of these vectors would facilitate the control of these diseases. Fluralaner is a novel isoxazoline that selectively blocks the GABA- and glutamate-gated channels, providing potent insecticidal and acaricidal activity. The aim of the current study was to provide quantitative data on the susceptibility of males, females and third nymphal instar of O...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28799685/ecological-factors-influencing-small-mammal-infection-by-anaplasma-phagocytophilum-and-borrelia-burgdorferi-s-l-in-agricultural-and-forest-landscapes
#2
Grégoire Perez, Suzanne Bastian, Amélie Chastagner, Albert Agoulon, Olivier Plantard, Gwenaël Vourc'h, Alain Butet
Small mammals are key components of numerous tick-borne disease systems, as hosts for immature ticks and pathogen reservoirs. To study the factors influencing tick-borne infection in small mammals, we trapped small mammals and collected questing ticks in spring and autumn in 2012 and 2013 at 24 sites in a 10x15 km rural landscapes (Brittany, France). Tissue samples were screened by real-time PCR for Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato. Of the two dominant small mammal species captured, bank voles (Myodes glareolus) had higher prevalence than wood mice (Apodemus sylvaticus) for both infections, presumably because of specific differences in immunological defenses...
August 11, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28798904/tick-borne-viruses-and-biological-processes-at-the-tick-host-virus-interface
#3
REVIEW
Mária Kazimírová, Saravanan Thangamani, Pavlína Bartíková, Meghan Hermance, Viera Holíková, Iveta Štibrániová, Patricia A Nuttall
Ticks are efficient vectors of arboviruses, although less than 10% of tick species are known to be virus vectors. Most tick-borne viruses (TBV) are RNA viruses some of which cause serious diseases in humans and animals world-wide. Several TBV impacting human or domesticated animal health have been found to emerge or re-emerge recently. In order to survive in nature, TBV must infect and replicate in both vertebrate and tick cells, representing very different physiological environments. Information on molecular mechanisms that allow TBV to switch between infecting and replicating in tick and vertebrate cells is scarce...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28791846/serum-carnitine-and-acyl-carnitine-in-patients-with-meningitis-due-to-tick-borne-encephalitis-virus-infection
#4
Alina Kępka, Roman M Janas, Sławomir A Pancewicz, Renata Świerzbińska
BACKGROUND: Hard ticks are the main vectors of tick-borne encephalitis virus (TBEV). Free carnitine (FC) and acylcarnitines (AC) have the basic role in β-oxidation as well as the modulation of immune and nervous system. Homeostasis of carnitines in the TBE patients was not studied so far. OBJECTIVES: This study aimed to evaluate FC and AC serum concentrations in patients with meningitis due to TBEV infection before and after 14 ± 3 days of treatment. MATERIAL AND METHODS: The study was performed in 14 patients aged 48 ± 29 years that were divided a posteriori (based on their FC level before and after treatment) into 2 subgroups: 1-8 and 9-14...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28780117/targeting-a-global-health-problem-vaccine-design-and-challenges-for-the-control-of-tick-borne-diseases
#5
REVIEW
José de la Fuente, Marinela Contreras, Agustín Estrada-Peña, Alejandro Cabezas-Cruz
It has been over twenty years since the first vaccines for the control of tick infestations became commercially available. These vaccines proved their efficacy and the potential of this approach for the control of tick-borne diseases (TBDs), which represent a growing burden for human and animal health worldwide. In all these years, research in this area has produced new tick-derived and pathogen-derived candidate protective antigens. However, the potential of vaccines for the control of TBDs has been underestimated due to major challenges to reduce tick infestations, pathogen infection, multiplication and transmission, tick attachment and feeding time and/or host pathogen infection...
August 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28774342/crimean-congo-hemorrhagic-fever-among-the-one-humped-camel-camelus-dromedaries-in-central-sudan
#6
Hajer M Suliman, Ibrahim A Adam, Shamseldin I Saeed, Sanaa A Abdelaziz, Eltahir M Haroun, Imadeldin E Aradaib
BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonotic disease caused by Crimean-Congo hemorrhagic fever virus (CCHFV), a member of the genus Nairovirus in the family Bunyaviridae. CCHF is typically asymptomatic in animals but can be highly fatal in humans approaching case fatality rate of approximately 30%. In the present investigation, a cross sectional study was conducted to determine the prevalence of CCHF and to identify the potential risk factors associated with CCHFV seropositivity among the one-humped camel (Camelus dromedaries) in Central Sudan...
August 3, 2017: Virology Journal
https://www.readbyqxmd.com/read/28770638/systematic-literature-review-comparing-rapid-3-dose-administration-of-the-gsk-tick-borne-encephalitis-vaccine-with-other-primary-immunization-schedules
#7
Ilaria Galgani, Eveline M Bunge, Lisa Hendriks, Christopher Schludermann, Cinzia Marano, Laurence De Moerlooze
Tick-borne encephalitis (TBE), which is endemic across large regions of Europe and Asia, is most effectively prevented through vaccination. Three-dose primary TBE vaccination schedules are either rapid (0,7,21-days) or conventional (0,28-84-days, 9-12-months). The second dose can also be administered at 14 days for faster priming and sero-protection). Areas covered: We used a three-step selection process to identify 21 publications comparing the immunogenicity and/or safety of different schedules. Expert commentary: Priming with two or three TBE vaccine doses was highly immunogenic...
September 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28770219/quantifying-the-availability-of-vertebrate-hosts-to-ticks-a-camera-trapping-approach
#8
Tim R Hofmeester, J Marcus Rowcliffe, Patrick A Jansen
The availability of vertebrate hosts is a major determinant of the occurrence of ticks and tick-borne zoonoses in natural and anthropogenic ecosystems and thus drives disease risk for wildlife, livestock, and humans. However, it remains challenging to quantify the availability of vertebrate hosts in field settings, particularly for medium-sized to large-bodied mammals. Here, we present a method that uses camera traps to quantify the availability of warm-bodied vertebrates to ticks. The approach is to deploy camera traps at questing height at a representative sample of random points across the study area, measure the average photographic capture rate for vertebrate species, and then correct these rates for the effective detection distance...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28769894/a-historical-overview-of-research-on-babesia-orientalis-a-protozoan-parasite-infecting-water-buffalo
#9
REVIEW
Lan He, Qin Liu, Baoan Yao, Yanqin Zhou, Min Hu, Rui Fang, Junlong Zhao
Babesiosis is a globally important zoonotic disease caused by tick-borne intraerythrocytic protozoan of the genus Babesia (phylum apicomplexa). In China, there are five species that infect cattle buffalo and cause great economic loss, which include Babesia bigemina, B. bovis, B. major, B. ovata, and B. orientalis. Among them, B. orientalis is the most recently identified new Babesia species epidemic in China. This review summarized the work done in the past 33 years to give an overview of what learned about this parasite...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28768435/cycluridine-a-novel-antiviral-effective-against-flaviviruses
#10
REVIEW
Angel S Galabov, Lucia Mukova, Yuriy P Abashev, Lilia Wassilewa, Petko Tzvetkov, Vassil Minkov, Igor F Barinskiy, Charles M Rice, Sergey Ouzounov, Dorotea Sidzhakova
This review describes the contemporary state of research for antivirals effective against flaviviruses, especially focusing on inhibitors of the pestivirus causative agent of bovine viral diarrhoea virus. We highlight cycluridine, an originally synthesized Mannich's base [a tetrahydro-2(1H)-pyrimidinones derivative], as a highly effective antiviral possessing a strong inhibitory effect on bovine viral diarrhoea virus replication. Cycluridine was active against replication of a wide variety of bovine viral diarrhoea virus strains in cell cultures...
August 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/28764743/one-particular-anaplasma-phagocytophilum-ecotype-infects-cattle-in-the-camargue-france
#11
Thibaud Dugat, Agnès Leblond, Nicolas Keck, Anne-Claire Lagrée, Isabelle Desjardins, Aurélien Joulié, Sophie Pradier, Benoit Durand, Henri-Jean Boulouis, Nadia Haddad
BACKGROUND: Anaplasma phagocytophilum is a zoonotic tick-borne pathogen responsible for granulocytic anaplasmosis, a mild to a severe febrile disease that affects man and several animal species, including cows and horses. In Europe, I. ricinus is the only proven vector for this pathogen, but studies suggest that other tick genera and species could be involved in its transmission. Our objective was to assess the presence and genetic diversity of A. phagocytophilum in domestic animals and different tick species from the Camargue region, located in the south of France...
August 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28762591/ean-consensus-review-on-prevention-diagnosis-and-management-of-tick-borne-encephalitis
#12
REVIEW
P Taba, E Schmutzhard, P Forsberg, I Lutsar, U Ljøstad, Å Mygland, I Levchenko, F Strle, I Steiner
BACKGROUND AND PURPOSE: Tick-borne encephalitis (TBE) is an infection of the central nervous system (CNS) caused by tick-borne encephalitis virus (TBEV) and transmitted by ticks, with a variety of clinical manifestations. The incidence of TBE in Europe is increasing due to an extended season of the infection and the enlargement of endemic areas. Our objectives are to provide recommendations on the prevention, diagnosis and management of TBE, based on evidence or consensus decisions. METHODS: For systematic evaluation, the literature was searched from 1970 to 2015 (including early online publications of 2016), and recommendations were based on evidence or consensus decisions of the Task Force when evidence-based data were not available...
August 1, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28755284/morphological-anomalies-in-ixodes-ricinus-and-ixodes-inopinatus-collected-from-tick-borne-encephalitis-natural-foci-in-central-europe
#13
Lidia Chitimia-Dobler, Malena Bestehorn, Michael Bröker, Johannes Borde, Tomas Molcanyi, Nanna Skaarup Andersen, Martin Pfeffer, Gerhard Dobler
In 2015, 0.02% nymphs displayed anomalies (ectromely) out of the 6744 collected ticks as part of a tick-borne encephalitis program in Germany. In 2016, questing Ixodes ricinus (n = 14,527) and Ixodes inopinatus (n = 75) ticks were collected by flagging as part of a tick-borne encephalitis program in Germany, Slovakia and Denmark. A total of 278 (1.9%) out of 14,602 nymph and adult ticks showed morphological anomalies. The anomalies were divided into general anomalies (body asymmetry) and local anomalies (anomalies of appendages, malformation of capitulum, exoskeleton anomalies and anal groove deformation) with nymphs being the most affected life stage...
July 28, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28754151/identification-of-anaplasma-ovis-appendage-associated-protein-aaap-for-development-of-an-indirect-elisa-and-its-application
#14
Zhenguo Wang, Jifei Yang, Qingli Niu, Kelly A Brayton, Jianxun Luo, Guangyuan Liu, Hong Yin, Zhijie Liu
BACKGROUND: Ovine anaplasmosis is a tick-borne disease that is caused by Anaplasma ovis in sheep and goats. The pathogen is widely distributed in tropical and subtropical regions of the world. At present, diagnosis of the disease mainly depends on microscopy or nucleic acid based molecular tests, although a few serological tests have been applied for the detection of A. ovis infection. RESULTS: Here we describe the identification of an A. ovis protein that is homologous to the A...
July 28, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28750862/alteration-of-haemostatic-parameters-in-uncomplicated-canine-babesiosis
#15
Josipa Kuleš, Jelena Gotić, Vladimir Mrljak, Renata Barić Rafaj
Babesiosis is a tick-borne zoonotic disease caused by haemoprotozoan parasites. The aim of this study were to assess markers of coagulation pathways in 25 dogs with naturally occurring babesiosis caused by B. canis, compared to 10 healthy controls. Protein C (PC) and antithrombin III (AT III) activity were assessed using a chromogenic substrate test, while levels of thrombin-antithrombin (TAT) complexes, activated protein C (APC) and endothelial protein C receptor were assessed using canine-specific ELISA. AT III activity was decreased as a result of a negative acute phase response, degradation by elastase, reduced availability of glycosaminoglycans, and, most importantly, consumption as a consequence of thrombin formation...
August 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28749289/clinical-disease-associated-with-anaplasma-phagocytophilum-infection-in-captive-przewalski-s-horses-equus-ferus-przewalskii
#16
Richard R Sim, Priscilla H Joyner, Luis R Padilla, Paul Anikis, Copper Aitken-Palmer
Anaplasma phagocytophilum is a tick-borne pathogen of domestic horses and the causative agent of equine granulocytic anaplasmosis. This case series describes three confirmed cases of clinical anaplasmosis, and a fourth case of presumptive anaplasmosis in Przewalski's horses ( Equus ferus przewalskii) housed at the Smithsonian Conservation Biology Institute from 2008 to 2014. Clinical signs varied among individuals with affected horses exhibiting lethargy, weakness, pyrexia, hypophagia, reluctance to move, or ataxia...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28747674/increased-prevalence-of-severe-fever-with-thrombocytopenia-syndrome-in-eastern-china-clustered-with-multiple-genotypes-and-reasserted-virus-during-2010-2015
#17
Zhifeng Li, Jianli Hu, Lunbiao Cui, Ye Hong, Jianwei Liu, Pengfei Li, Xiling Guo, Wendong Liu, Xiaochen Wang, Xian Qi, Bin Wu, Zhi Feng, Aihua Shen, Xuejian Liu, Hongjun Zhao, Wenwen Tan, Jiangang Zhou, Zheng Xing, Changjun Bao
Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne viral disease with high mortality. Since January 2010, we have conducted an epidemiological surveillance and etiological study of SFTS in Jiangsu and Anhui provinces. From January 2010 through December 2015, a total of 286 SFTS cases were confirmed in Jiangsu and Anhui provinces with a case fatality rate of 16.1%. The majority of confirmed SFTS cases were distributed in the border area of Jiangsu and Anhui provinces. Our findings suggest that the SFTS prevalence rate rose since 2010 and reached its highest in 2015...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28742149/predicting-the-risk-of-lyme-borreliosis-after-a-tick-bite-using-a-structural-equation-model
#18
Agnetha Hofhuis, Jan van de Kassteele, Hein Sprong, Cees C van den Wijngaard, Margriet G Harms, Manoj Fonville, Arieke Docters van Leeuwen, Mariana Simões, Wilfrid van Pelt
BACKGROUND: Understanding and quantification of the risk of Lyme borreliosis after a tick bite can aid development of prevention strategies against Lyme borreliosis. METHODS: We used 3,525 single tick bite reports from three large prospective studies on the transmission risk of tick-borne pathogens to humans, with 50 reports of Lyme borreliosis during the follow-up period, among 1,973 reports with known outcome. A structural equation model was applied to estimate the risk of Lyme borreliosis after a tick bite, and quantify the influence of: developmental stage of the tick, detection of Borrelia burgdorferi s...
2017: PloS One
https://www.readbyqxmd.com/read/28741465/engineering-of-chimeric-protein-based-on-e-protein-domain-iii-of-tick-borne-encephalitis-virus-and-ompf-porin-of-yersinia-pseudotuberculosis
#19
Anna M Stenkova, Natalia S Chopenko, Ludmila A Davydova, Andrey N Mazeika, Evgeniya P Bystritskaya, Olga Y Portnyagina, Stanislav D Anastyuk, Dmitrii S Kulbatskii, Ekaterina N Lyukmanova, Dmitriy A Dolgikh, Eduard Y Kostetsky, Nina M Sanina
Tick-borne encephalitis poses a serious public health threat in the endemic regions. The disease treatment is restricted to symptomatic therapy, so great expectations are in the development of the prophylactic and therapeutic vaccines. The domain III of E protein of the tick-borne encephalitis virus is the main antigenic domain which includes virus-specific epitopes recognized by neutralizing antibodies. We have expressed, isolated and characterized the chimeric protein based on the fusion of domain III of E protein of the tick-borne encephalitis virus and bacterial porin OmpF from Yersinia pseudotuberculosis...
July 24, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28739494/amblyomma-maculatum-secis-binding-protein-2-and-putative-selenoprotein-p-are-indispensable-for-pathogen-replication-and-tick-fecundity
#20
Khemraj Budachetri, Gary Crispell, Shahid Karim
Selenium, a vital trace element, is incorporated into selenoproteins to produce selenocysteine. Our previous studies have revealed an adaptive co-evolutionary process that has enabled the spotted fever-causing tick-borne pathogen Rickettsia parkeri to survive by manipulating an antioxidant defense system associated with selenium, which includes a full set of selenoproteins and other antioxidants in ticks. Here, we conducted a systemic investigation of SECIS binding protein 2 (SBP2) and putative selenoprotein P (SELENOP) by transcript silencing in adult female Gulf-coast ticks (Amblyomma maculatum)...
July 21, 2017: Insect Biochemistry and Molecular Biology
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