keyword
https://read.qxmd.com/read/38540668/cloflucarban-illuminates-specificity-and-context-dependent-activation-of-the-pink1-parkin-pathway-by-mitochondrial-complex-inhibition
#21
JOURNAL ARTICLE
Adrian T Ramirez, Zeyu Liu, Quanbin Xu, Sarah Nowosadtko, Xuedong Liu
The PTEN-induced kinase 1 (PINK1)-Parkin pathway plays a vital role in maintaining a healthy pool of mitochondria in higher eukaryotic cells. While the downstream components of this pathway are well understood, the upstream triggers remain less explored. In this study, we conducted an extensive analysis of inhibitors targeting various mitochondrial electron transport chain (ETC) complexes to investigate their potential as activators of the PINK1-Parkin pathway. We identified cloflucarban, an antibacterial compound, as a novel pathway activator that simultaneously inhibits mitochondrial complexes III and V, and V...
February 20, 2024: Biomolecules
https://read.qxmd.com/read/38540590/attitude-of-the-lithuanian-public-toward-medical-assistance-in-dying-a-cross-sectional-study
#22
JOURNAL ARTICLE
Benedikt Bachmetjev, Artur Airapetian, Rolandas Zablockis
Euthanasia and assisted suicide, involving the intentional termination of a patient's life, are subjects of global debate influenced by cultural, ethical, and religious beliefs. This study explored the attitudes of the general public toward euthanasia, finding varying levels of support. A cross-sectional study was conducted. This research specifically evaluated the perspectives of 5804 Lithuanian residents using a survey distributed through social media, which presented medical scenarios on life-preserving interventions...
March 10, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38540164/hyperchloremia-and-hypernatremia-decreased-microglial-and-neuronal-survival-during-oxygen-glucose-deprivation-reperfusion
#23
JOURNAL ARTICLE
Reetika Mahajan, Faheem Shehjar, Adnan I Qureshi, Zahoor A Shah
Hyperchloremia and hypernatremia are associated with higher mortality in ischemic stroke, but it remains unclear whether their influence directly contributes to ischemic injury. We investigated the impact of 0.9% sodium chloride (154 mM NaCl), 0.9% sodium acetate (167 mM CH3 COONa), and their different combinations (3:1, 2:1, and 1:1) on microglial (HMC-3) and neuronal (differentiated SH-SY5Y) survival during oxygen-glucose deprivation/reperfusion (OGD/R). Further, we assessed the effect of hyperchloremia and hypernatremia-treated and OGD/R-induced HMC-3-conditioned media on differentiated SH-SY5Y cells under OGD/R conditions...
February 29, 2024: Biomedicines
https://read.qxmd.com/read/38539775/exploration-of-resonant-modes-for-circular-and-polygonal-chladni-plates
#24
JOURNAL ARTICLE
Amira Val Baker, Mate Csanad, Nicolas Fellas, Nour Atassi, Ia Mgvdliashvili, Paul Oomen
In general, sound waves propagate radially outwards from a point source. These waves will continue in the same direction, decreasing in intensity, unless a boundary condition is met. To arrive at a universal understanding of the relation between frequency and wave propagation within spatial boundaries, we explore the maximum entropy states that are realized as resonant modes. For both circular and polygonal Chladni plates, a model is presented that successfully recreates the nodal line patterns to a first approximation...
March 15, 2024: Entropy
https://read.qxmd.com/read/38538852/novel-insights-into-the-co-selection-of-metal-driven-antibiotic-resistance-in-bacteria-a-study-of-arsenic-and-antibiotic-co-exposure
#25
JOURNAL ARTICLE
Farhana Haque, Farzana Diba, Arif Istiaq, Mohammad Anwar Siddique, Taslin Jahan Mou, M Anwar Hossain, Munawar Sultana
The simultaneous development of antibiotic resistance in bacteria due to metal exposure poses a significant threat to the environment and human health. This study explored how exposure to both arsenic and antibiotics affects the ability of an arsenite oxidizer, Achromobacter xylosoxidans CAW4, to transform arsenite and its antibiotic resistance patterns. The bacterium was isolated from arsenic-contaminated groundwater in the Chandpur district of Bangladesh. We determined the minimum inhibitory concentration (MIC) of arsenite, cefotaxime, and tetracycline for A...
March 28, 2024: Archives of Microbiology
https://read.qxmd.com/read/38538765/research-on-predicting-the-driving-forces-of-digital-transformation-in-chinese-media-companies-based-on-machine-learning
#26
JOURNAL ARTICLE
Zhan Wang, Yao Li, Xu Zhao, Yuxuan Wang, Zihan Xiao
Chinese media companies are facing opportunities and challenges brought about by digital transformation. Media economics takes the evaluation of the business results of media companies as the main research topic. However, overcoming the internal differences in the industry and comprehensively predicting the digital transformation of Chinese media companies from multiple dimensions has become an important issue to be understood. Based on the "TOE-I" theoretical framework, this study innovatively uses machine learning methods to predict the digital transformation of Chinese media companies and to analyze specific modes of the main driving factors affecting the digital transformation, using data from China's A-share-listed media companies from 2010 to 2020...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38538257/conditioned-media-from-deer-antler-stem-cells-effectively-alleviate-type-1-diabetes-mellitus-possibly-via-inhibiting-the-nf-%C3%AE%C2%BAb-signaling-pathway
#27
JOURNAL ARTICLE
Dongxu Wang, Jing Ren, Jiping Li, Xiuying Li, Jinchi Ying, Tiantian Jiang, Zhen Wang, Zheng Pan, Qianqian Guo, Chunyi Li, Guokun Zhang
BACKGROUND: Type 1 diabetes mellitus (T1D) represents a severe threat to human health. Persistent hyperglycemia and dyslipidemia can lead to damaged liver function, while effective interventions for these complications are currently lacking. Deer antler stem cells (AnSCs), a novel type of adult stem cells, significantly reduced liver injury, which was speculated to be achieved through the paracrine pathway. METHODS: In this study, AnSC-conditioned medium (AnSC-CM) was used to treat C57BL/6 mice with T1D symptoms induced by streptozotocin (STZ)...
March 11, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38537799/mechanical-energy-triggered-piezo-catalyzation-of-bi-2-wo-6-nanoplates-on-ferrate-fe-vi-oxidation-in-alkaline-media-performance-and-mechanism
#28
JOURNAL ARTICLE
Jinzhe Li, Chuyun Fu, Meng Zhu, Xinwen Huang, Shuang Song, Feilong Dong
Piezo-electricity, as a unique physical phenomenon, demonstrates high effectiveness in capturing the environmental mechanical energy into polarization charges, offering the possibility to activate the advanced oxidation processes via the electron pathway. However, information regarding the intensification of Fe(VI) through piezo-catalysis is limited. Therefore, our study is the first to apply Bi2 WO6 nanoplates for piezo-catalyzation of Fe(VI) to enhance bisphenol A (BPA) degradation. Compared to Fe(VI) alone, the Fe(VI)/piezo/Bi2 WO6 system exhibited excellent BPA removal ability, with the degradation rate increased by 32...
March 25, 2024: Environmental Pollution
https://read.qxmd.com/read/38537135/first-report-of-white-mucus-disease-caused-by-fuligo-gyrosa-on-agrocybe-chaxingu-in-china
#29
JOURNAL ARTICLE
Xutao Chen, Qing Liu, Guoliang Meng, Xinhong Peng, Caihong Dong, Yunhui Wei, Guanghua Huo
Agrocybe chaxingu is an edible and medicinal mushroom widely cultivated in China (Liu et al. 2021). Agrocybe chaxingu is extremely well-liked for the unique flavor and nutritional value. In May 2021, a serious white mucus disease was observed in the farms of A. chaxingu in the Ganxian district of Ganzhou City, Jiangxi Province, China, with an approximate disease incidence of 20%. In the years of 2022 and 2023, the same white mucus disease on A. chaxingu was observed in the farms in Nanchang City, Jiujiang City and Guangchang County, Jiangxi Province, China...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537079/amino-acid-supplementation-confers-protection-to-red-blood-cells-prior-to-plasmodium-falciparum-bystander-stress
#30
JOURNAL ARTICLE
Heather Colvin Binns, Elmira Alipour, Cameron E Sherlock, Dinah S Nahid, John F Whitesides, Anderson O'Brien Cox, Cristina M Furdui, Glen S Marrs, Daniel B Kim-Shapiro, Regina Joice Cordy
Malaria is a highly oxidative parasitic disease in which anemia is the most common clinical symptom. A major contributor to malarial anemia pathogenesis is the destruction of bystander, uninfected red blood cells (RBCs). Metabolic fluctuations are known to occur in the plasma of individuals with acute malaria, emphasizing the role of metabolic changes in disease progression and severity. Here, we report that conditioned media from Plasmodium falciparum culture induces oxidative stress in uninfected, catalase-depleted RBCs...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38536966/the-effect-of-boxwood-leaf-volatiles-on-conidial-germination-of-calonectria-pseudonaviculata-the-causal-agent-of-boxwood-blight
#31
JOURNAL ARTICLE
Mana Ohkura, Bryan R Beck, Carolyn F Scagel, Jerry E Weiland
The fungal pathogen Calonectria pseudonaviculata causes boxwood blight and is a significant threat to the boxwood industry as well as historic boxwood gardens. The pathogen produces conidia in sticky masses that are splash dispersed, which germinate and infect through stomata on the leaves or stems, causing leaf spots and stem lesions. Despite its ability to cause severe infections on boxwood plants, the pathogen often has a low germination rate on artificial media under lab conditions. To identify cues that stimulate germination, we explored whether host factors could induce high germination rates...
March 27, 2024: Phytopathology
https://read.qxmd.com/read/38536415/stress-induced-microautophagy-is-coordinated-with-lysosome-biogenesis-and-regulated-by-pikfyve
#32
JOURNAL ARTICLE
Alison D Klein, Kayla L Petruzzi, Chan Lee, Michael Overholtzer
Lysosome turnover and biogenesis are induced in response to treatment of cells with agents that cause membrane rupture, but whether other stress conditions engage similar homeostatic mechanisms is not well understood. Recently we described a form of selective turnover of lysosomes that is induced by metabolic stress or by treatment of cells with ionophores or lysosomotropic agents, involving the formation of intraluminal vesicles within intact organelles through microautophagy. Selective turnover involves non-canonical autophagy and the lipidation of LC3 onto lysosomal membranes, as well as the autophagy gene-dependent formation of intraluminal vesicles...
March 27, 2024: Molecular Biology of the Cell
https://read.qxmd.com/read/38535675/influence-of-concentration-surface-charge-and-natural-water-components-on-the-transport-and-adsorption-of-polystyrene-nanoplastics-in-sand-columns
#33
JOURNAL ARTICLE
Gabriela Hul, Hande Okutan, Philippe Le Coustumer, Stéphan Ramseier Gentile, Stéphane Zimmermann, Pascal Ramaciotti, Pauline Perdaems, Serge Stoll
Information about the influence of surface charges on nanoplastics (NPLs) transport in porous media, the influence of NPL concentrations on porous media retention capacities, and changes in porous media adsorption capacities in the presence of natural water components are still scarce. In this study, laboratory column experiments are conducted to investigate the transport behavior of positively charged amidine polystyrene (PS) latex NPLs and negatively charged sulfate PS latex NPLs in quartz sand columns saturated with ultrapure water and Geneva Lake water, respectively...
March 15, 2024: Nanomaterials
https://read.qxmd.com/read/38535479/maximizing-polysaccharides-and-phycoerythrin-in-porphyridium-purpureum-via-the-addition-of-exogenous-compounds-a-response-surface-methodology-approach
#34
JOURNAL ARTICLE
Sanjiong Yi, Ai-Hua Zhang, Jianke Huang, Ting Yao, Bo Feng, Xinghu Zhou, Yadong Hu, Mingxuan Pan
Phycoerythrin and polysaccharides have significant commercial value in medicine, cosmetics, and food industries due to their excellent bioactive functions. To maximize the production of biomass, phycoerythrin, and polysaccharides in Porphyridium purpureum , culture media were supplemented with calcium gluconate (CG), magnesium gluconate (MG) and polypeptides (BT), and their optimal amounts were determined using the response surface methodology (RSM) based on three single-factor experiments. The optimal concentrations of CG, MG, and BT were determined to be 4, 12, and 2 g L-1 , respectively...
March 21, 2024: Marine Drugs
https://read.qxmd.com/read/38535229/the-oxidative-stress-response-highly-depends-on-glucose-and-iron-availability-in-aspergillus-fumigatus
#35
JOURNAL ARTICLE
Tamás Emri, Károly Antal, Kinga Varga, Barnabás Csaba Gila, István Pócsi
Pathogens have to cope with oxidative, iron- and carbon(glucose)-limitation stresses in the human body. To understand how combined iron-carbon limitation alters oxidative stress responses, Aspergillus fumigatus was cultured in glucose-peptone or peptone containing media supplemented or not with deferiprone as an iron chelator. Changes in the transcriptome in these cultures were recorded after H2 O2 treatment. Responses to oxidative stress were highly dependent on the availability of glucose and iron. Out of the 16 stress responsive antioxidative enzyme genes, only the cat2 catalase-peroxidase gene was upregulated in more than two culturing conditions...
March 18, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38534558/the-nitrogen-content-in-the-fruiting-body-and-mycelium-of-pleurotus-ostreatus-and-its-utilization-as-a-medium-component-in-thraustochytrid-fermentation
#36
JOURNAL ARTICLE
Lina Schütte, Katharina Hausmann, Christoph Schwarz, Franziska Ersoy, Ralf G Berger
Following the idea of a circular bioeconomy, the use of side streams as substitutes for cultivation media (components) in bioprocesses would mean an enormous economic and ecological advantage. Costly compounds in conventional media for the production of the triterpene squalene in thraustochytrids are the main carbon source and complex nitrogen sources. Among other side streams examined, extracts from the spent mycelium of the basidiomycete Pleurotus ostreatus were best-suited to acting as alternative nitrogen sources in cultivation media for thraustochytrids...
March 16, 2024: Bioengineering
https://read.qxmd.com/read/38534527/three-milliliters-of-peripheral-blood-is-sufficient-for-preparing-liquid-platelet-rich-fibrin-prf-an-in-vitro-study
#37
JOURNAL ARTICLE
Sarah Al-Maawi, Eva Dohle, Robert Sader, Shahram Ghanaati
Platelet-rich fibrin (PRF) has assumed an important role in supporting tissue regeneration in different fields. To date, the standard protocol for liquid PRF requires at least 10 mL of peripheral blood. The present study aimed to analyze the composition, growth factor release, and effects on the cell proliferation of PRF samples produced using 3 mL vs. 10 mL of peripheral blood in vitro. Peripheral venous blood from six healthy donors was used to prepare liquid PRF using either 3 mL or 10 mL tubes. Three different centrifugation protocols were used according to the low-speed centrifugation concept...
March 4, 2024: Bioengineering
https://read.qxmd.com/read/38534243/a-careful-insight-into-ddi-type-receptor-layers-on-the-way-to-improvement-of-click-biology-based-immunosensors
#38
JOURNAL ARTICLE
Sylwia Karoń, Marcin Drozd, Elżbieta Malinowska
Protein-based microarrays are important tools for high-throughput medical diagnostics, offering versatile platforms for multiplex immunodetection. However, challenges arise in protein microarrays due to the heterogeneous nature of proteins and, thus, differences in their immobilization conditions. This article advocates DNA-directed immobilization (DDI) as a solution, emphasizing its rapid and cost-effective fabrication of biosensing platforms. Thiolated single-stranded DNA and its analogues, such as ZNA® and PNA probes, were used to immobilize model proteins ( anti -CRP antibodies and SARS-CoV nucleoprotein)...
March 6, 2024: Biosensors
https://read.qxmd.com/read/38533367/co-occurrence-of-otitis-media-with-effusion-and-another-environment-dependent-disease-selected-allergic-conditions
#39
JOURNAL ARTICLE
Oksana Wojas, Edyta Krzych-Fałta, Konrad Furmańczyk, Diana Dziewa-Dawidczyk, Bolesław Samoliński, Piotr Samel-Kowalik
INTRODUCTION: Otitis media eith effusion (OME) is an inflammatory condition of the middle ear that involves accumulation of sterile fluid or effusion in the tympanic cavity with the tympanic membrane intact. The pathophysiology of OME is undoubtedly multifactorial. AIM: To assess the co-occurrence of OME, allergic rhinitis, and asthma. MATERIAL AND METHODS: The study involved a group of 18,617 subjects aged 6-7 years, 13-14 years, or 20-44 years...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38531440/visualization-of-phenanthrene-effect-on-biochar-colloids-transport-in-porous-media
#40
JOURNAL ARTICLE
Ying Zhao, Da Fan, Jiabin Ma, Heng Li, Zhuqing Liu, Fan Yang
Biochar colloids (BCs) can be used as adsorbent materials for remediation of phenanthrene due to their high specific surface area and other characteristics. Understanding the effects of phenanthrene on the transport of BCs contributes to facilitate the removal of phenanthrene in soil and water habitats. In this work, the influence of phenanthrene on the transport of BCs under different environmental factors (pH, ionic strength (IS), media size) in a one-dimensional sand column was firstly explored together with a real-time visualization system to explore the transport mechanism of BCs in two-dimensional sand tank...
March 24, 2024: Science of the Total Environment
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