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https://www.readbyqxmd.com/read/29678749/benefit-of-bet-v-1-contiguous-overlapping-peptide-immunotherapy-persists-during-first-follow-up-season
#1
Alexander Kettner, Gilles DellaCorte, Fréderic de Blay, Lars Jacobsen, Marek Jutel, Margitta Worm, Vincent Charlon, Kim Simonsen, Christophe Reymond, François Spertini
A short course of 5 injection AIT with Bet v 1 Contiguous Overlapping Peptides was well tolerated and improved allergic rhinitis during the 2nd pollen season after treatment. Long lasting efficacy was associated with a persistent allergen-specific IgG4 response.
April 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29675865/allergen-immunotherapy-in-people-dogs-cats-and-horses-differences-similarities-and-research-needs
#2
R S Mueller, E Jensen-Jarolim, F Roth-Walter, E Marti, J Janda, A A Seida, D DeBoer
In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Subcutaneous, epicutaneous, intralymphatic, oral and sublingual protocols of AIT exist. In animals, most data are available in dogs where subcutaneous AIT is an accepted treatment for atopic dermatitis...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29675754/influence-of-mp-29-02-on-ciliary-beat-frequency-in-human-epithelial-cells-in-vitro
#3
D Häussler, J U Sommer, A Nastev, C Aderhold, A Wenzel, B Kramer, B A Stuck, R Birk
PURPOSE: MP 29-02, which contains fluticasone propionate and azelastine hydrochloride, is used as a topical nasal application for the treatment of seasonal and perennial allergic rhinitis. Although a multitude of data is available on the clinical symptom reduction and treatment safety of MP 29-02, the effect of MP 29-02 on ciliary beat frequency (CBF) has not been evaluated thus far. METHODS: MP 29-02-containing solution was applied at concentrations of 2.5, 5, 10, and 20% to 14 healthy subjects, and nasal ciliated epithelial cells were then visualized using a phase-contrast microscope...
April 19, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29667465/association-of-serum-specific-ige-levels-with-asthma-in-autumn-pollen-induced-allergic-rhinitis-a-retrospective-analysis
#4
Le Cui Md, Jia Yin Md
BACKGROUND: Artemisia and Humulus pollen are the two most important aeroallergens of autumn allergies in North China. Cross-sectional data in 2001 have shown that allergic rhinitis often preceded or occurred at the same time as asthma in patients with autumn pollinosis in North China. OBJECTIVE: We used this cross-sectional data to investigate the association of serum specific IgE (sIgE) levels to Humulus and/or Artemisia pollen with the onset of asthma in patients with autumn pollen-induced allergic rhinitis...
April 18, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29656291/activin-a-is-a-pro-inflammatory-regulator-in-type-2-driven-upper-airway-disease
#5
Adam M Chaker, Ulrich Matthias Zissler, Nikolaos Poulos, Martin Wagenmann, Murat Bas, Ferdinand Gürth, Georgina Xanthou, Carsten Schmidt-Weber
BACKGROUND: Allergic upper airway disease involves pro-inflammatory type-2 cytokines such as IL-5 and regulatory tissue repair mediators, in particular transforming growth factor (TGF)-β1. The TGF-β-superfamily member activin-A displays multiple biological functions and shares certain signalling pathways with TGF-β1. We aimed to examine the coregulation of mucosal activin-A and TGF-β1 in acute allergic and chronic Th2-driven upper airway disease. METHODS: We investigated mucosal cytokine expression profiles and kinetics using RT-PCR after nasal allergen challenges in patients with seasonal allergic rhinitis...
April 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29644866/diagnostic-accuracy-of-symptoms-endoscopy-and-imaging-signs-of-chronic-rhinosinusitis-without-nasal-polyps-compared-to-allergic-rhinitis
#6
A Koskinen, J Numminen, A Markkola, J Karjalainen, T Karstila, M Seppälä, A Julkunen, R Lemmetyinen, J Pekkanen, M Rautiainen, P Dastidar, M Hytönen, S Toppila-Salmi
Objectives The diagnosis of chronic rhinosinusitis without nasal polyps (CRSsNP) and distinguishing it from allergic rhinitis is difficult. Yet, early detection of CRSsNP is important to prevent progressive and severe chronic rhinosinusitis. Our aim was to compare diagnostic accuracy of symptoms, endoscopy, and imaging signs of CRSsNP and allergic rhinitis -only phenotypes. Setting Prospective controlled follow-up study. Participants Forty-two nonsmoking patients visiting tertiary care due to CRSsNP and 19 nonsmoking volunteer controls with allergic rhinitis filled a symptoms questionnaire and underwent nasal endoscopy off-seasonally...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29620294/-seasonal-allergic-rhinitis
#7
Igor Salvadé, Laura Moi, Camillo Ribi, François Spertini
Allergic diseases are currently amongst the most frequent diseases of our time. Of all the allergies in the Western countries, allergic rhinoconjunctivitis is the most common. Its diagnosis is based mainly on the history and the correlation between symptoms and contact with the allergen. A step-by-step approach helps optimize diagnostic resources and minimize costs.
April 4, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29603916/phase-1-pharmacokinetics-and-phase-3-efficacy-of-testosterone-nasal-gel-in-subjects-with-seasonal-allergies
#8
Alan D Rogol, Natalia Tkachenko, Philipp Badorrek, Jens M Hohlfeld, Nathan Bryson
INTRODUCTION: NATESTO® testosterone nasal gel (TNG) is a liquid gel that is applied in the nose for the treatment of male hypogonadism. There is a reasonable concern that administration of TNG to patients with active rhinitis could modify absorption. Results from two clinical studies are reported wherein subjects with allergic rhinitis (AR) subjects are treated with TNG. METHODS: The 24-hour pharmacokinetics (PK) and relative bioavailability of serum total testosterone (sTT) from TNG (11 mg tid ) were determined using a phase 1 Latin-square design with 18 eugonadal AR subjects crossed over between asymptomatic, symptomatic-untreated, and symptomatic-treated (oxymetazoline) conditions...
March 19, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29602839/association-of-allergic-diseases-with-children-s-life-satisfaction-population-based-study-in-finland
#9
Leena Haanpää, Piia Af Ursin, Merja Nermes, Anne Kaljonen, Erika Isolauri
OBJECTIVE: To assess the impact of allergic diseases on the subjective well-being and life satisfaction of primary-school children. DESIGN: Population-based cohort. SETTING: Finnish sample of children ages 10 and 12 from the International Survey of Children's Well-Being. PARTICIPANTS: Nationally representative sample of 1947 school children. MAIN OUTCOME MEASURE: Two different instruments to assess the child's own perception of well-being, the short version of the Student Life Satisfaction Scale (SLSS) and the Brief Multidimensional Student Life Satisfaction Scale (BMSLSS)...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29579655/dynamic-ecological-observations-from-satellites-inform-aerobiology-of-allergenic-grass-pollen
#10
Rakhesh Devadas, Alfredo R Huete, Don Vicendese, Bircan Erbas, Paul J Beggs, Danielle Medek, Simon G Haberle, Rewi M Newnham, Fay H Johnston, Alison K Jaggard, Bradley Campbell, Pamela K Burton, Constance H Katelaris, Ed Newbigin, Michel Thibaudon, Janet M Davies
Allergic diseases, including respiratory conditions of allergic rhinitis (hay fever) and asthma, affect up to 500 million people worldwide. Grass pollen are one major source of aeroallergens globally. Pollen forecast methods are generally site-based and rely on empirical meteorological relationships and/or the use of labour-intensive pollen collection traps that are restricted to sparse sampling locations. The spatial and temporal dynamics of the grass pollen sources themselves, however, have received less attention...
March 23, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29574559/how-do-storms-affect-asthma
#11
REVIEW
Gennaro D'Amato, Isabella Annesi-Maesano, Adriano Vaghi, Lorenzo Cecchi, Maria D'Amato
PURPOSE OF REVIEW: There are observations in various geographical areas that thunderstorms occurring during pollen seasons can induce severe asthma attacks in pollinosis patients. RECENT FINDINGS: An accredited hypothesis explaining the association between thunderstorms and asthma suggests that storms can concentrate pollen grains at ground level, which may then release allergenic particles of respirable size in the atmosphere after their imbibition of water and rupture by osmotic shock...
March 24, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29562802/house-dust-mite-sublingual-immunotherapy-in-allergic-rhinitis
#12
Sung-Woo Cho, Doo Hee Han, Jeong-Whun Kim, Dong-Young Kim, Chae-Seo Rhee
Allergen immunotherapy has been shown to be effective in treatment of allergic rhinitis (AR). Sublingual immunotherapy (SLIT) is generally recommended for treating seasonal AR in adults and children; however, questions remain in regard to AR treatment in relation to house dust mite (HDM). Due to heterogeneous formulations, different outcome reporting systems, and the lack of a standardized dose, HDM SLITs have not been standardized in published studies. Nevertheless, studies continuously report positive effects of HDM SLIT in AR, and HDM SLIT remains a treatment option for patients with HDM-induced allergic asthma that frequently co-exists with AR...
March 22, 2018: Immunotherapy
https://www.readbyqxmd.com/read/29551533/immunotherapy-with-the-sq-tree-slit-tablet-in-adults-and-adolescents-with-allergic-rhinoconjunctivitis
#13
Mika J Mäkelä, Pär Gyllfors, Erkka Valovirta, Maria A Steffensen, Pernille M Grønager, Johannes Savolainen, Lone Winther
PURPOSE: The SQ tree sublingual immunotherapy (SLIT)-tablet containing allergen extracts with the major allergen Bet v 1 from birch pollen is currently being developed for the treatment of tree pollen-induced allergic rhinitis/conjunctivitis with or without asthma. The aim of this Phase II trial was to investigate the dose-related efficacy and safety of the SQ tree SLIT-tablet. METHODS: This study was a randomized, parallel-group, double-blind, placebo-controlled, multi-national trial conducted in Europe...
March 15, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29545433/recurrence-of-eosinophilic-oesophagitis-with-subcutaneous-grass-pollen-immunotherapy
#14
Rosy Wells, A T Fox, Mark Furman
Case reports have described an association between oral food/aeroallergen immunotherapy with the development of eosinophilic oesophagitis (EoE). The underlying mechanism of this is poorly understood, as is the role that both food/aeroallergen sensitisation plays in the pathogenesis of EoE. Specific immunotherapy has a long-standing history of use in the management of moderate/severe seasonal allergic rhinitis (AR), caused by tree/grass pollens. Subcutaneous immunotherapy (SCIT) to grass pollen is less commonly used in children than sublingual immunotherapy (SLIT) or oral immunotherapy for practical reasons...
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29524924/adverse-health-effects-of-ferronickel-manufacturing-factory-on-local-residents-an-interrupted-time-series-analysis
#15
Changwoo Han, Yun-Chul Hong
The first ferronickel manufacturing factory of the Republic of Korea was opened in Gwangyang City on October, 23rd, 2008. There has been public concern regarding heavy metal dust blown from the factory and slag disposal site. Therefore, we evaluated the health impact of the ferronickel factory on Gwangyang City residents by using interrupted time series analysis. We analyzed the monthly incidence patterns of asthma, allergic rhinitis, and dermatitis in Gwangyang City residents from 2004 to 2014. Data were gathered from the National Health Insurance Service database which covers all the hospital use data of entire city residents...
March 7, 2018: Environment International
https://www.readbyqxmd.com/read/29520147/a-10-year-retrospective-study-of-alterative-aeroallergens-sensitization-spectrum-in-urban-children-with-allergic-rhinitis
#16
Li-Fen Yang, Liang-Ming Cai, Ming Li, Jin-Tao Liu, Zhao-Ni Wang, Wei-Hao Wang, Qin-Tai Yang, Zhuang-Gui Chen
Objective: To investigate the alterative spectrum and trends of aeroallergens sensitization in children with allergic rhinitis (AR) in Guangzhou, China in the past 10 years. Participants and methods: In this retrospective study, 4,111 children with complaints of nasal hyper-reactivity who visited the Pediatric Department and/or Otolaryngology Department from January 2007 to November 2016 were enrolled. Serum specific immunoglobulin E was measured and positive detection was made in 3,328 patients, who were, therefore, diagnosed with AR...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29512827/short-course-of-grass-allergen-peptides-immunotherapy-over-three-weeks-reduces-seasonal-symptoms-in-allergic-rhinoconjunctivitis-with-without-asthma-a-randomized-multicenter-double-blind-placebo-controlled-trial
#17
Ralph Mösges, Claus Bachert, Petr Panzner, Moises A Calderon, Ludo Haazen, Sabine Pirotton, Nathalie Wathelet, Stephen R Durham, Marie-Alix Bonny, Thierry Legon, Remy von Frenckell, Oliver Pfaar, Mohamed H Shamji
BACKGROUND: Immunotherapy with peptide hydrolysates from Lolium perenne (LPP) is an alternative treatment for seasonal allergic rhinitis with or without asthma. The aim of this study was to assess the clinical efficacy and safety of a cumulative dose of 170 μg LPP administered subcutaneously over 3 weeks. METHODS: In a randomized, double blind, placebo-controlled trial, 554 adults with grass pollen rhinoconjunctivitis were randomized (1:2 ratio) to receive 8 subcutaneous injections of placebo or 170 μg LPP administered in increasing doses in 4 visits over 3 weeks...
March 7, 2018: Allergy
https://www.readbyqxmd.com/read/29480876/patients-demographics-of-a-convenient-clinic-located-in-a-large-railway-station-in-metropolitan-tokyo-area
#18
Kenji Tsuda, Tetsuya Tanimoto, Saori Sakaue, Tomohiko Sato, Kaduki Kouno, Tamae Hamaki, Kazutaka Hosoda, Mutsuko Ohnishi, Tsunehiko Komatsu, Masahiro Kami, Eiji Kusumi
Hidden barriers to visit a medical facility especially for young busy workers have been neglected in the aging society. The aim of this cross-sectional study is to analyze demographics of patients who had visited the first known convenient clinic located inside a railway station, which is adjusted to the lifestyle of working generations.We analyzed de-identified data of patients who had visited the department of internal medicine of a clinic, which is located inside a railway station building and offers primary care with after-hours accessibility in Tokyo, between August 2013 and June 2016...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29477567/-outdoor-moulds-and-respiratory-health
#19
REVIEW
D Caillaud, M Cheriaux, D Charpin, N Chaabane, M Thibaudon
Mould spores constitute the largest portion of biologic particulate matter suspended in the outdoor atmosphere. There is no universal method for collecting airborne mould spores. The most used sampler, Hirst's apparatus, operates continuously and gives results in individual spores per cubic metre of air. Spore concentrations depend on available substrates, human activities such as agriculture, season, diurnal meteorological variations and climate changes. Under natural conditions, concentrations of over 100,000 spores per cubic metre are not exceptional...
February 21, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29459528/-a-validation-study-of-the-improved-product-for-measuring-japanese-cypress-pollen-specific-ige-thermo-scientific-%C3%A2-immunocap-%C3%A2-immunocap-japanese-cypress-pollen-specific-ige
#20
Syuji Yonekura, Yoshitaka Okamoto, Satoshi Nakayama
BACKGROUND: Japanese cypress pollen is a major causative allergen of seasonal allergic rhinitis in Japan. Although ImmunoCAP-specific immunoglobulin E (IgE) reagent Japanese cypress pollen has been widely used as a diagnostic aid, its sensitivity requires enhancement. This study evaluated an improved version of this reagent. METHODS: Serum samples from 61 subjects who underwent Japanese cypress pollen exposure testing in an environmental challenge chamber in Chiba University were assessed using the conventional ImmunoCAPspecific IgE Japanese cypress pollen product and the improved product...
2018: Arerugī, [Allergy]
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