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https://www.readbyqxmd.com/read/29778591/complications-of-antibiotic-cement-spacers-used-for-shoulder-infections
#1
Edward G McFarland, Jorge Rojas, Jeremy Smalley, Amrut U Borade, Jacob Joseph
BACKGROUND: Our aim was to evaluate complications related to commercially available antibiotic cement spacers used in the treatment of shoulder infections. METHODS: We performed a retrospective review of commercially available antibiotic spacers implanted in 53 patients (60 spacers) between April 2009 and October 2017 as part of a 2-stage treatment plan for infection at the site of a shoulder arthroplasty (n = 39), other (non-arthroplasty) shoulder surgery (n = 8), or primary shoulder infection without previous surgery (n = 6)...
May 16, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29778274/outcomes-of-tibia-shaft-fractures-caused-by-low-energy-gunshot-wounds
#2
Charles A Su, Mai P Nguyen, Jeffrey A O'Donnell, Heather A Vallier
BACKGROUND: The purpose of this project was to compare the rates of infections, nonunions, malunions, and secondary operations in tibia fractures resultant from low energy GSWs versus those seen in open and closed tibia fractures resultant from blunt trauma. A secondary objective was to assess the utility of using the traditional Gustilo-Anderson classification system for open fractures to describe fractures secondary to low energy GSW. METHODS: A retrospective review of 327 patients with tibia shaft fractures was conducted at our level I trauma center...
May 16, 2018: Injury
https://www.readbyqxmd.com/read/29774402/subtrochanteric-and-diaphyseal-femoral-fractures-in-hypophosphatasia-not-atypical-at-all
#3
F Genest, L Seefried
Risk for subtrochanteric and diaphyseal femoral fractures is considered increased in patients with hypophosphatasia (HPP). Evaluating a large cohort of HPP patients, we could for the first time quantify the prevalcence and identify both morphometric features as well as predisposing factors for this complication of severe HPP. INTRODUCTION: Subtrochanteric and diaphyseal femoral fractures have been associated with both, long-term antiresorptive treatment and metabolic bone disorders, specifically Hypophosphatasia (HPP)...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29773926/comparative-analysis-of-airborne-bacteria-and-fungi-in-two-salt-mines-in-poland
#4
Elżbieta Gębarowska, Wojciech Pusz, Jolanta Kucińska, Włodzimierz Kita
The aim of this work was to determine the genera or species composition and the number of colony forming units of airborne bacteria and fungi, respectively, in two salt mines in Poland "Wieliczka" (Lesser Poland) and "Polkowice-Sieroszowice" (Lower Silesia). Both of them are working environments characterized by extreme conditions, and additionally "Wieliczka," officially placed on the UNESCO World Heritage Sites' list, plays a role of tourist attraction. There are also some curative chambers located in this mine...
2018: Aerobiologia
https://www.readbyqxmd.com/read/29772988/combined-labeled-leukocyte-and-technicium-99-sulfur-colloid-bone-marrow-imaging-differentiating-primary-pyomyositis-pseudotumor-from-osteomyelitis-and-multiple-bone-infarcts
#5
Paul W Perdue, Allison B Spitzer, Dipal Chatterjee, Srinivas Kolla, Aditya V Maheshwari
A 53 year old-female patient with lupus had undergone a cephalo-medullary nailing for a femur shaft fracture 30 years ago. This was complicated by osteomyelitis, requiring multiple debridement procedures and hardware removal. Recently, she developed a painful soft tissue mass in the same region, which was ultimately diagnosed as pyomyositis. Because of chronic bone changes due to her past history, traditional imaging could not differentiate between osteomyelitis infarction and pseudotumor. A combined indium-labeled leukocyte scan with a technetium-99 sulfur colloid marrow scan ruled out osteomyelitis and guided proper treatment without osseous debridement and thus prevented unnecessary cross-contamination of the bone...
2018: Journal of Long-term Effects of Medical Implants
https://www.readbyqxmd.com/read/29769779/comparison-of-hair-shafts-angles-using-a-curved-blade-an-innovation
#6
Muhammad Ahmad
Background: The study was conducted to compare the angles of the hair shafts created by straight/flat blade and curved blade. Materials and Methods: The study was conducted in a private hair transplant surgery center. Five patients undergoing thefirst session of hair transplant were included. In each patient, 1 cm2 area was selected in the anterior hairline in midline. Five slits were created with 1.0 mm straight/flat blade and five slits were created with 1.0 mm curved blade in each patient...
March 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29766701/new-multi-targeting-strategy-in-hair-growth-promotion-in-vitro-and-in-vivo-studies
#7
Barbara Marzani, Daniela Pinto, Elisabetta Sorbellini, Fabio Rinaldi
BACKGROUND: Considering the importance of hair in our modern society and the impact of hair loss, the efforts of researchers are addressed to better understand the mechanisms behind the hair cycle regulation and dysregulation. Because hair loss is multifactorial, differenced and new approaches are required. In particular we addressed our attention to two recently identified targets in hair cycling and growth control: olfactory receptor and autophagy. The aim of the study was to evaluate: the possible pro-autophagic effect of N1-methylspermidine (a spermidine analogue) in vitro and, in a double blind clinical trial, the safety and efficacy of topical daily application of a lotion containing N1-methylspermidine and Sandalore®...
June 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29765881/determinants-of-hip-and-femoral-deformities-in-children-with-spastic-cerebral-palsy
#8
Yoona Cho, Eun Sook Park, Han Kyul Park, Jae Eun Park, Dong-Wook Rha
Objective: To find factors affecting hip and femoral deformities in children with spastic cerebral palsy (CP) by comparing various clinical findings with imaging studies including plain radiography and computed tomography (CT) imaging. Methods: Medical records of 709 children with spastic CP who underwent thorough baseline physical examination and functional assessment between 2 to 6 years old were retrospectively reviewed. Fifty-seven children (31 boys and 26 girls) who had both plain radiography of the hip and three-dimensional CT of the lower extremities at least 5 years after baseline examination were included in this study...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29761053/nature-derived-lignan-compound-vb-1-exerts-hair-growth-promoting-effects-by-augmenting-wnt-%C3%AE-catenin-signaling-in-human-dermal-papilla-cells
#9
Jieshu Luo, Mengting Chen, Yingzi Liu, Hongfu Xie, Jian Yuan, Yingjun Zhou, Jinsong Ding, Zhili Deng, Ji Li
Background: Vitexin is a kind of lignan compound which has been shown to possess a variety of pharmacological effects, such as anti-inflammatory, anti-oxidative and anti-cancer activities. However the effect of vitexin on hair regeneration has not been elaborated. Methods: The proliferation of human dermal papilla cells (hDPCs) was examined by cell counting and continuous cell culture after vitexin compound 1 (VB-1) was treated. The expression of lef1 , wnt5a , bmp2 , bmp4 , alpl and vcan was examined by RT-PCR...
2018: PeerJ
https://www.readbyqxmd.com/read/29758267/the-functional-architecture-of-axonal-actin
#10
REVIEW
Marie-Jeanne Papandréou, Christophe Leterrier
The cytoskeleton builds and supports the complex architecture of neurons. It orchestrates the specification, growth, and compartmentation of the axon: axon initial segment, axonal shaft, presynapses. The cytoskeleton must then maintain this intricate architecture for the whole life of its host, but also drive its adaptation to new network demands and changing physiological conditions. Microtubules are readily visible inside axon shafts by electron microscopy, whereas axonal actin study has long been focused on dynamic structures of the axon such as growth cones...
May 11, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29757278/a-microbiomechanical-system-for-studying-varicosity-formation-and-recovery-in-central-neuron-axons
#11
Dustin Servello, Yuanzheng Gu, Chen Gu
Axonal varicosities are enlarged structures along the shafts of axons with a high degree of heterogeneity. They are present not only in brains with neurodegenerative diseases or injuries, but also in the normal brain. Here, we describe a newly-established micromechanical system to rapidly, reliably, and reversibly induce axonal varicosities, allowing us to understand the mechanisms governing varicosity formation and heterogeneous protein composition. This system represents a novel means to evaluate the effects of compression and shear stress on different subcellular compartments of neurons, different from other in vitro systems that mainly focus on the effect of stretching...
April 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29756511/surface-integrity-of-polyethylene-liners-following-trunnionosis-of-a-dual-modular-neck-total-hip-implant
#12
Ben Gi Spiegelberg, Brent A Lanting, James L Howard, Matthew G Teeter, Douglas Dr Naudie
BACKGROUND: There has been a trend in the evolution of total hip arthroplasty towards increased modularity; with this increase in modularity come some potentially harmful consequences. Modularity at the neck shaft junction has been linked to corrosion, adverse reaction to metal debris and pseudotumour formation. AIM: The aim of this retrieval study is to assess whether the surface integrity of the polyethylene (PE) liner is affected by metal wear debris in a single implant design series of THA revised for trunnionosis...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29752798/review-of-human-hair-optical-properties-in-possible-relation-to-melanoma-development
#13
Xiyong Huang, Michael D Protheroe, Ahmed M Al-Jumaily, Sharad P Paul, Andrew N Chalmers
Immigration and epidemiological studies provide evidence indicating the correlation of high ultraviolet exposure during childhood and increased risks of melanoma in later life. While the explanation of this phenomenon has not been found in the skin, a class of hair has been hypothesized to be involved in this process by transmitting sufficient ultraviolet rays along the hair shaft to possibly cause damage to the stem cells in the hair follicle, ultimately resulting in melanoma in later life. First, the anatomy of hair and its possible contribution to melanoma development, and the tissue optical properties are briefly introduced to provide the necessary background...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29748878/clinical-and-radiological-outcome-of-gustilo-type-iii-open-distal-tibial-and-tibial-shaft-fractures-after-staged-treatment-with-posterolateral-minimally-invasive-plate-osteosynthesis-mipo-technique
#14
Xiaojian He, Chuanzhen Hu, Kaihua Zhou, Qilin Zhai, Weifeng Wen, Fugen Pan
OBJECTIVES: To evaluate the methods and the outcomes of Gustilo type III open distal tibial and tibial shaft fractures with severe anterior and medial soft-tissue injuries, treated with posterolateral minimally invasive plate osteosynthesis (MIPO) technique. METHODS: From May 2015 to May 2016, 10 patients with Gustilo type III open distal tibial and tibial shaft fractures with severe anterior and medial soft-tissue injuries (Gustilo-Anderson classification IIIA, 6; IIIB, 4) were treated with staged protocol using posterolateral minimally invasive plate osteosynthesis (MIPO) technique...
May 10, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29747480/simpl-a-simplified-model-based-program-for-the-analysis-and-visualization-of-groundwater-rebound-in-abandoned-mines-to-prevent-contamination-of-water-and-soils-by-acid-mine-drainage
#15
Sung-Min Kim, Yosoon Choi
Cessation of dewatering following underground mine closure typically results in groundwater rebound, because mine voids and surrounding strata undergo flooding up to the levels of the decant points, such as shafts and drifts. SIMPL (Simplified groundwater program In Mine workings using the Pipe equation and Lumped parameter model), a simplified lumped parameter model-based program for predicting groundwater levels in abandoned mines, is presented herein. The program comprises a simulation engine module, 3D visualization module, and graphical user interface, which aids data processing, analysis, and visualization of results...
May 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29742594/capillary-hemangioma-as-an-unusual-cause-of-doughnut-sign-on-bone-scan
#16
Omar Q Samarah, Mohammad I Tayyem, Nisreen Abu Shahin, Ghadeer AlMuhaisen, Malik E Juweid
A 28-year-old woman presented with a mass in her right leg, which, on plain radiograph, appeared as a lytic lesion in the mid-shaft of the tibia with cortical thinning but without periosteal reaction. Tc-MDP 3-phase bone scan demonstrated intense uptake in the periphery of the mass with a photopenic center, the so-called doughnut sign. Histopathology revealed a capillary hemangioma. This case demonstrates that the doughnut sign on bone scan can be caused by capillary hemangioma in addition to other reported bone pathologies, including aneurysmal bone cyst, giant cell tumor, and telangiectatic osteosarcoma...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29738529/identifying-novel-strategies-for-treating-human-hair-loss-disorders-cyclosporine-a-suppresses-the-wnt-inhibitor-sfrp1-in-the-dermal-papilla-of-human-scalp-hair-follicles
#17
Nathan J Hawkshaw, Jonathan A Hardman, Iain S Haslam, Asim Shahmalak, Amos Gilhar, Xinhong Lim, Ralf Paus
Hair growth disorders often carry a major psychological burden. Therefore, more effective human hair growth-modulatory agents urgently need to be developed. Here, we used the hypertrichosis-inducing immunosuppressant, Cyclosporine A (CsA), as a lead compound to identify new hair growth-promoting molecular targets. Through microarray analysis we identified the Wnt inhibitor, secreted frizzled related protein 1 (SFRP1), as being down-regulated in the dermal papilla (DP) of CsA-treated human scalp hair follicles (HFs) ex vivo...
May 2018: PLoS Biology
https://www.readbyqxmd.com/read/29737368/-minimally-invasive-correction-of-lesser-toe-deformities-and-treatment-of-metatarsalgia
#18
REVIEW
M Thomas, M Jordan
OBJECTIVE: Atraumatic and joint-sparing procedure for the correction of lesser toe deformities by using a linear or perpendicular osteotomy of the proximal and/or middle phalanx of the lesser toes with additional capsulotomies or tendon dissection for soft tissue realignment. Metatarsalgia is addressed via an extracapsular distal metaphyseal crescentic-like metatarsal osteotomy. INDICATIONS: Symptomatic lesser toe deformities, painful pseudoexostosis, metatarsalgia, symptomatic metatarsal malalignment, metatarsus adductus...
May 8, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29736726/high-incidence-of-intraoperative-calcar-fractures-with-the-cementless-cls-spotorno-stem
#19
Carla Timmer, Davey M J M Gerhardt, Enrico de Visser, Marinus de Kleuver, Job L C van Susante
INTRODUCTION: This study reports on the incidence of intraoperative calcar fractures with the cementless Spotorno (CLS) stem, and the potential role of a learning curve and implant positioning is investigated. METHODS: After introduction of the CLS stem, 800 consecutive cementless total hip arthroplasties (THA) were analyzed. The incidence of calcar fracture in the first 400 THA was compared with the second 400 THA, in order to study a potential learning curve effect...
May 7, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29735375/which-additional-augmented-fixation-procedure-decreases-surgical-failure-after-proximal-humeral-fracture-with-medial-comminution-fibular-allograft-or-inferomedial-screws
#20
Doo-Sup Kim, Doo-Hyung Lee, Yong-Min Chun, Sang-Jin Shin
BACKGROUND: The purpose of this study was to compare clinical and radiologic results between treatment with locking plate fixation and fibular allograft augmentation (FA) and treatment with locking plate fixation and additional inferomedial screws (IMSs) in 3- or 4-part proximal humeral fractures with medial comminution in geriatric patients. METHODS: We enrolled 164 patients with 3- or 4-part proximal humeral fractures with medial comminution who were treated with locking plates...
May 4, 2018: Journal of Shoulder and Elbow Surgery
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