Hal Blumberg, Huyen Dinh, Charles Dean, Esther S Trueblood, Keith Bailey, Donna Shows, Narasimharao Bhagavathula, Muhammad Nadeem Aslam, James Varani, Jennifer E Towne, John E Sims
Psoriasis is a common immune-mediated disease in European populations; it is characterized by inflammation and altered epidermal differentiation leading to redness and scaling. T cells are thought to be the main driver, but there is also evidence for an epidermal contribution. In this article, we show that treatment of mouse skin overexpressing the IL-1 family member, IL-1F6, with phorbol ester leads to an inflammatory condition with macroscopic and histological similarities to human psoriasis. Inflammatory cytokines thought to be important in psoriasis, such as TNF-α, IL-17A, and IL-23, are upregulated in the mouse skin...
October 1, 2010: Journal of Immunology